Sang Soo Hah, Ph.D.
Professor, Department of Chemistry, Kyung Hee University
26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, South Korea
Tel) +82-2-961-2186 (Office), +82-2-961-0832 & +82-2-961-2283 (Lab)
Fax) +82-2-961-0443
E-Mail) sshah at khu.ac.kr
EXPERIENCES
09/2008 – present Assistant Professor/Associate Professor/Professor (Department of Chemistry, Kyung Hee University, Seoul, South Korea)
11/2020 – 11/2026 Committee Member (Advisory Committee on Forensic Science, Supreme Prosecutors’ Office, Seoul, South Korea)
01/2019 – 12/2021 Program Director (Science Core, Humanitas College, Kyung Hee University, Seoul, South Korea)
02/2017 – 01/2019 Department Chair (Department of Chemistry, Kyung Hee University, Seoul, South Korea)
03/2016 – 02/2018 Department Chair (Graduate School of Education (Chemistry Eduation Major), Kyung Hee University, Seoul, South Korea)
09/2014 – 08/2015 Visiting Scholar (Department of Chemistry, California Institute of Technology, Pasadena, CA)
10/2013 – 09/2015 Public Relations Coordinator (IUPAC-2015 Organizing Committee)
2012 – 2013 Committee Member (2012 and 2013 MEET/DEET Exam.)
03/2012 – 02/2014 Department Chair (Graduate School of Education (Chemistry Eduation Major), Kyung Hee University, Seoul, South Korea)
12/2010 – 10/2011 Director (Research Center for New Nano Bio Fusion Technology (RCNB), Kyung Hee University, Seoul, South Korea)
02/2008 – 06/2008 Research Fellow and Bioanalytical Laboratory Director (Accium Biosciences, Inc., Seattle, WA)
10/2005 – 09/2007 Principal Investigator (LW-LDRD, 06-LW-023) on a Department of Energy/Lawrence Livermore National Laboratory Project (Lawrence Livermore National Laboratory, Livermore, CA)
01/2004 – 01/2008 Postdoctoral Research Staff Member (Biosciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA)
2003 Principal Instructor (2 semesters) in the Columbia Science Honors Program for Talented High School Students (Columbia University, New York, NY)
01/2002 – 12/2003 Postdoctoral Researcher (Department of Chemistry, Columbia University, New York, NY)
09/2001 – 12/2001 Postdoctoral Researcher (Center for Molecular Catalysis, Seoul National University, Seoul, South Korea)
PEER-REVIEWED PUBLICATIONS (AFTER JOINING KHU)
Lee, G.-H.; Kang, S. M.; Lee, S. B.; Lee, D.; Ko, Y.; Nam, J.; Jo, J.; Hah, S. S.* Monitoring of cell-dependent reduced states using aptamer-functionalized reduction-sensitive quantum dots. Bull. Korean Chem. Soc.
Kang, S.; Chae, W.; Suh, S.-K.; Jung, W.; Chang, D.-J.*; Hah, S. S.* HER2 RNA aptamer- and cell penetrating peptide-mediated delivery of multimeric antisense strands of siRNAs for gene silencing. Bull. Korean Chem. Soc.
Hong, C.; Baek, A.; Hah, S. S.; Jung, W.; Kim, D.-E.* Fluorometric detection of microRNA using isothermal gene amplification and graphene oxide. Anal. Chem.
Cho, Y. S.; Lee, E. J.; Lee, G.-H.; Hah, S. S.* Aptamer selection for fishing of palladium ion using graphene oxide-adsorbed nanoparticles. Bioorg. Med. Chem. Lett.
Park, S. M.; Hah, S. S.* Allele-Specific Hybridization-Based Washing-Free Fluorescence Signal Production Platforms for Quantitation of Single-Base Change (C->U) in RNA. Bull. Korean Chem. Soc.
Lee, G.-H.; Yu, B.-Y.; Kim, J.*; Song, J. H.*; Hah, S. S.* Accelerator mass spectrometry-based signal generation for thin layer chromatography. Bull. Korean Chem. Soc.
Kang, S.; Hah, S. S.* Improved ligand binding by antibody-aptamer pincers. Bioconjug. Chem.
Song, S.; Cho, Y. S.; Lee, S.-J.; Hah, S. S.* Aptamer-based precipitation as an alternative to the conventional immunoprecipitation for purification of target proteins. Bull. Korean Chem. Soc.
Suh, S.-K.; Song, S.; Oh, H.-B.; Hwang, S.-H.*; Hah, S. S.* Aptamer-based competitive binding assay for one-step quantitation of hepatitis B surface antigen. Analyst
Park, J. H.; Cho, Y. S.; Kang, S.; Lee, E. J.; Lee, G.-H.; Hah, S. S.* A colorimetric sandwich-type assay for sensitive thrombin detection based on enzyme linked aptamer assay. Anal. Biochem.
Lee, E. J.; Cho, Y. S.; Song, S.; Hwang, S.-H.*; Hah, S. S.* FRET-based quantitative discrimination of bisulfate-untreated DNA from bisulfate-treated DNA. Bull. Korean Chem. Soc.
Kang, W.; Hong, S. H.; Lee, H. M.; Kim, N. Y.; Lim, Y. C.; Le, L. T. M.; Kim, H. C.; Kim, T. Y.; Ashida, H.; Yokota, A.; Hah, S. S.; Chun, K. H.; Jung, Y.-K.; Yang, J. K.* Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme. Proc. Natl. Acad. Sci. USA
Hwang, S.-H.; Im, S.-G.; Sung, H.; Hah, S. S.; Cong, V. T.; Lee, D.-H.; Son, S. J.; Oh, H.-B.* Upconversion nanoparticle-based Föster resonance energy transfer for detecting the IS6110 sequence of Mycobacterium tuberculosis complex in sputum. Biosens. Bioelectron.
Lee, G.-H.; Lee, E. J.; Hah, S. S.* TAMRA- and Cy5-labeled probe for efficient kinetic characterization of caspase-3. Anal. Biochem.
Jeong, M.; Park, J. M.; Lee, E. J.; Cho, Y. S.; Lee, C.; Kim, J. M.; Hah, S. S.* Cytotoxicity of ultra-pure TiO2 and ZnO nanoparticles generated by laser ablation. Bull. Korean Chem. Soc.
Hwang, S.-H.; Im, S.-G.; Hah, S. S.; Cong, V. T.; Lee, E. J.; Lee, Y.-S.; Lee, G. K.; Lee, D.-H.*; Son, S. J.* Effects of upconversion nanoparticles on polymerase chain reaction. PLoS One
Cho, Y. S.; Lee, E. J.; Shin, S.; Hah, S. S.* Combination of aptamer-functionalized quantum dots and electrophoretic mobility shift assay for specific detection and quantitation of proteins of interest. Quant. Bio-Sci.
Shin, S.; Kim, Y. S.; Kim, J.; Kwon, H.-M.; Kim, D.-E.*; Hah, S. S.* Sniffing for gene silencing efficiency of siRNAs in HeLa cells in comparison with that in HEK293T cells: Correlation between knockdown efficiency and sustainability of siRNAs revealed by FRET-based probing. Nucleic Acid Therapeutics
Lee, E. J.; Lim, H. K.; Cho, Y. S.; Hah, S. S.* Peptide nucleic acids are an additional class of aptamers. RSC Adv.
Nam, H. Y.; Cho, Y. S.; Jung, W.; Kang, H.-J.; Hah, S. S.* RNA aptamer-functionalized quantum dots for detection of His-tagged proteins in Escherichia coli. Bull. Korean Chem. Soc.
Kim, J.; Lee, G.-H.; Jung, W.; Hah, S. S.* Selective and quantitative cell detection based both on aptamers and the conventional cell-staining methods. Biosens. Bioelectron.
Lim, H. K; Kim, I.-H.; Nam, H. Y.; Shin, S.; Hah, S. S.* Aptamer-based alternatives to the conventional immobilized metal affinity chromatography for purification of His-tagged proteins. Anal. Lett.
Lee, G.-H.; Lim, H. K; Jung, W.; Hah, S. S.* Incorporation efficiency of 5’-azido-5’-deoxyguanosine into 5’-terminus of RNA for preparation of azido-functionalized RNA. Bull. Korean Chem. Soc.
Kim, Y. S; Kim, K. K.; Shin, S.; Park, S. M.*; Hah, S. S.* Comparative toxicity studies of ultra-pure Ag, Au, Co, and Cu nanoparticles generated by laser ablation in biocompatible aqueous solution. Bull. Korean Chem. Soc.
Shin, S.; Nam, H. Y.; Lee, E. J.; Jung, W.; Hah, S. S.* Molecular beacon-based quantitation of epithelial tumor marker Mucin1. Bioorg. Med. Chem. Lett.
Kim, M. Y.; Kim, J.; Hah, S. S.* Poly(A)-targeting molecular beacons: FRET-based in vitro quantitation and time-dependent imaging in live cells. Anal. Biochem.
Chung, D.; Kang, H.-J.; Jang, Y. P.*; Jung, W.; Hah, S. S.* Preparation of a thiolated derivative of A2E, a pigment of the lipofuscin of retinal pigment epithelial cells. Bull. Korean Chem. Soc.
Lee, G.-H.; Hah, S. S.* Ultrasensitive probing studies using accelerator mass spectrometry. ChemWorld (Review in Korean).
Hah, S. S.* Metabolomics for biomarker discovery based on accelerator mass spectrometry. J. Metabolomics (Editorial).
Lee, G.-H.; Hah, S. S.* Coomassie blue is sufficient for specific protein detection of aptamer-conjugated chips. Bioorg. Med. Chem. Lett.
Kim, S.-Y.; Kim, J.; Hwang, S.-H.*; Park, H.-K.; Lee, J.-H.; Lee, D.-H.; Hah, S. S., Park, D. Y. Pro-gastrin-releasing peptide (ProGRP) is a candidate marker for quality control in clinical sample processing and storage. Amer. J. Clin. Pathol.
Kim, Y. S.; Kim, M. Y.; Kim, T. J.*; Kim, Y. D.*; Hah, S. S.* Stepwise fluorescence changes of quantum dots: Single molecule spectroscopic studies on the properties of turn-on quantum dots. Chem. Commun.
Lee, G.-H.; Lim, H. K.; Hah, S. S.* Preparation of 5’-azido-5’-deoxyguanosine and its efficiency for click chemistry. Bull. Korean Chem. Soc.
Kim, J.; Kim, M. Y.; Kim, H. S.; Hah, S. S.* Binding of uranyl ion by a DNA aptamer attached to a solid support. Bioorg. Med. Chem. Lett.
Shin, S.; Kwon, H.-M.; Yoon, K.-S.; Kim, D.-E.*; Hah, S. S.* FRET-based probing to gain direct information on siRNA sustainability in live cells: Asymmetric degradation of siRNA strands. Mol. BioSyst.
Park, K.; Choi, B.-R.; Kim, Y. S.; Shin, S.; Hah, S. S.; Jung, W.; Oh, S.; Kim, D.-E.* Detection of single base mutation in RNA using T4 RNA ligase-based nick-joining or DNAzyme-based nick-generation. Anal. Biochem.
Kim, M. Y.; Kim, Y. S.; Kim, J.; Hah, S. S.*; Kim, T. J.; Kim, Y. D.* Quantum dots functionalized to quantify NADPH and their use for NADP+-dependent biocatalyzed transformations. Biotechnol. Lett.
Kim, I.-H.; Kim, M. Y.; Cheong, M.; Hah, S. S.* RNA-mediated metal-metal bond formation in the hexagonal Pd nanoparticle synthesis is not influenced by 5’-thiolation of RNA. Bull. Korean Chem. Soc.
Shin, S.; Kim, Y. S.; Kang, H.-J.; Hah, S. S.* Quantum dot-based aptasensor for sensitive protein detection. Bull. Korean Chem. Soc.
Kim, Y. S.; Shin, S.; Cheong, M.; Hah, S. S.* Mechanistic insights into in vitro DNA adduction of oxaliplatin. Bull. Korean Chem. Soc.
Kim, I.-H.; Shin, S.; Jeong, Y.-J.; Hah, S. S.* Two-step synthesis of 5’-deoxy-5’-thioguanosine-5’-monophosphorothioate and its incorporation efficiency into 5’-terminus of RNA for preparation of thiol-functionalized RNA. Tet. Lett.
Shin, S.; Kim, I.-H.; Kang, W.; Yang, J. K.; Hah, S. S.* An alternative to Western blot analysis using RNA aptamer-functionalized quantum dots. Bioorg. Med. Chem. Lett.
Kim, K; Kim, T. H.; Choi, J. H.; Lee, J. Y.; Hah, S. S.; Yoo, H.-O.; Hwang, S. S.; Ryu, K. N.; Kim, H. J.; Kim, J.* Synthesis of a pH-sensitive PEO-based block copolymer and its application for the stabilization of iron oxide nanoparticles. Marcomol. Chem. Phys.
Hah, S. S.*; Henderson, P. T.; Turteltaub, K. W. Towards biomarker-dependent individualized chemotherapy: Exploring cell-specific differences in oxaliplatin-DNA adduct distribution using accelerator mass spectrometry. Bioorg. Med. Chem. Lett.
Hah, S. S.*; Henderson, P. T.; Turteltaub, P. T. Recent advances in biomedical applications of accelerator mass spectrometry. J. Biomed. Sci.
PATENTS (AFTER JOINING KHU)
Hah, S. S.; Kang, S. Pincers comprising antibody and aptamer conjugated via a linker which binds to the same target material and use thereof (US Patent Number: 10/605,810).
Hah, S. S.; Cho, Y. S.; Lee, E. J. 팔라듐 이온 특이적 DNA 앱타머 및 이의 선별 방법 (Palladium ion-specific DNA aptamer and a method for selecting the same, Korea Patent Number: 10-1679140).
Hah, S. S.; Suh, S.-K.; Song, S.; Oh, H.-B.; Hwang, S.-H. 형광공명 에너지 전이 현상을 유발시키는 형광물질이 표지된 앱타머를 포함하는 표적물질 검출 또는 정량분석용 조성물 (Composition for detecting or quantitative analysis comprising aptamer tagged by fluorescent substance with fluorescence resonance transfer, Korea Patent Number: 10-1515723).
Hah, S. S.; Park, J. H.; Cho, Y. S.; Lee, E. J. 앱타머를 포함하는 ELISA 변형키트 (Alternative ELISA kit comprising aptamer, Korea Patent Number: 10-1515306).
Hah, S. S.; Lee, E. J. PNA 앱타머를 이용한 표적분자의 검출방법 (Method for detecting of target molecules using PNA aptamers, Korea Patent Number: 10-1535709).
Hah, S. S.; Shin, S.; Nam, H. Y.; Lee, E. J. 신규한 양자점-앱타머 결합체 및 이의 용도 (Novel quantum dot-aptamer conjugate and use thereof, Korea Patent Number: 10-1510513).
Hah, S. S.; Kim, J.; Lee, G.-H. 앱타머 칩을 이용한 표적 세포의 검출 및 정량 방법 (A method for detecting and quantifying target cells, Korea Patent Number: 10-1429817).
Hah, S. S.; Lee, G.-H. 앱타머 칩을 이용한 표적 단백질의 검출 및 정량 방법 (Method for detecting and quantifying target proteins, Korea Patent Number: 10-1502204).
Hah, S. S.; Kim, I.-H.; Lim, H. K.; Shin, S.; Nam, H. Y. 히스티딘 태그를 가진 단백질의 정제를 위한 고형 지지체 및 이를 이용한 정제 방법 (Solid support and method for purifying His-tagged protein, Korea Patent Number: 10-1333158).
Hah, S. S.; Kim, Y. S.; Shin, S.; Kim, M.; Kim, J.-S.; Kim, I.-H.; Chung, D. 양자점-앱타머 접합체를 이용한 생분석 방법 (Bioanalysis using quantum dot-aptamer conjugate, Korea Patent Number: 10-1090982).
Hah, S. S. 가교결합과 가속 질량 분석법의 조합에 의한 단백질-리간드 상호작용의 확인과 정량화 방법 (Method for checking and quantifying protein-ligand interaction by combining a crosslinking method and accelerator mass spectrometry, Korea Patent Number: 10-1137502).
BOOKS
Hah, S. S. Chemistry that changed the fate of mankind (in Korean) (ISBN: 978-89-8222-736-3).
Magna Historia Research Society (Hah, S. S., one of the authors) From big bang to civilization (in Korean) (ISBN: 978-89-368-1109-9).
EDUCATIONS
03/1996 – 08/2001 Seoul National University, Ph.D., Bioorganic Chemistry
03/1994 – 02/1996 Seoul National University, M.S., Bioorganic Chemistry
03/1990 – 02/1994 Seoul National University, B.S., Chemistry