{"id":963,"date":"2018-06-26T02:17:46","date_gmt":"2018-06-26T02:17:46","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=963"},"modified":"2023-07-05T15:43:31","modified_gmt":"2023-07-05T06:43:31","slug":"%ec%8b%9d%eb%ac%bc%ec%9d%b4-%ec%96%b4%eb%96%bb%ea%b2%8c-%ec%8b%9c%ea%b0%84%ec%9d%84-%ec%9d%b8%ec%a7%80%ed%95%98%eb%8a%94%ea%b0%80-%ec%83%9d%ec%b2%b4%ec%8b%9c%ea%b3%84%ec%9d%98-%eb%b9%84%eb%b0%80","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=963","title":{"rendered":"\uc2dd\ubb3c\uc774 \uc5b4\ub5bb\uac8c \uc2dc\uac04\uc744 \uc778\uc9c0\ud558\ub294\uac00, \uc0dd\uccb4\uc2dc\uacc4\uc758 \ube44\ubc00"},"content":{"rendered":"

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\uc9c0\uae08\uc73c\ub85c\ubd80\ud130 \uac70\uc758\u00a0300<\/span>\ub144 \uc804\uc778\u00a01729<\/span>\ub144 \ud504\ub791\uc2a4 \ucc9c\ubb38\ud559\uc790 \uc7a5–<\/span>\uc790\ud06c \ub3c4\ub974\ud22c \ub4dc \uba54\ub791\uc740 \ub0ae\uc5d0\ub294 \uc78e\uc744 \ud3bc\uce58\uace0 \ubc24\uc5d0\ub294 \uc811\ub294 \ubbf8\ubaa8\uc0ac\ub97c \ub300\uc0c1\uc73c\ub85c \uc4f8\ub370\uc5c6\uc5b4 \ubcf4\uc774\ub294 \uc2e4\ud5d8\uc744 \ud588\ub2e4.\u00a0<\/span>\uc989 \ubbf8\ubaa8\uc0ac\ub97c \ud558\ub8e8 \uc885\uc77c \ube5b\uc774 \ub4e4\uc5b4\uc624\uc9c0 \uc54a\ub294 \uacf5\uac04\uc5d0 \ub458 \uacbd\uc6b0 \uc78e\uc758 \uc6c0\uc9c1\uc784\uc774 \uc5b4\ub5bb\uac8c \ub420\uc9c0 \ud655\uc778\ud574\ubcf4\uae30\ub85c \ud55c \uac83\uc774\ub2e4.\u00a0<\/span><\/p>\n

\ube5b\uc774 \uc788\uc744 \ub54c \uad11\ud569\uc131 \ud6a8\uc728\uc744 \ub192\uc774\ub824\uace0 \uc78e\uc744 \ud65c\uc9dd \ud3bc\uce5c \uac83\uc77c \ud14c\ub2c8 \ucef4\ucef4\ud55c \uacf3\uc5d0 \ub450\uba74 \ubcf4\ub098 \ub9c8\ub098 \uc78e\uc744 \uc811\uc740 \ucc44 \ube5b\uc774 \ub2e4\uc2dc \ube44\ucd94\uae30\ub9cc \uae30\ub2e4\ub9ac\uace0 \uc788\uc744 \uac83\uc774\ub2e4.\u00a0<\/span>\uadf8\ub7ec\ub098 \ub180\ub78d\uac8c\ub3c4 \ubbf8\ubaa8\uc0ac\ub294 \uc5b4\ub460 \uc18d\uc5d0\uc11c\ub3c4 \uc774\uc804 \ub0ae\uc5d0 \ud574\ub2f9\ud558\ub294 \uc2dc\uac04\ub300\uc5d0\ub294 \uc78e\uc744 \ud3bc\uce58\uace0 \ubc24 \uc2dc\uac04\uc774 \ub418\uba74 \uc811\ub294 \ud328\ud134\uc744 \ud55c\ub3d9\uc548 \uc9c0\uc18d\ud588\ub2e4.\u00a0<\/span><\/p>\n

\uc678\ubd80 \ud658\uacbd\ubcc0\ud654,\u00a0<\/span>\uc989 \uc9c0\uad6c \uc790\uc804\uc73c\ub85c \uc778\ud55c \ub0ae\uacfc \ubc24\uc758 \uad50\ucc28\uac00 \uc5c6\uc5b4\ub3c4 \uc2dd\ubb3c\uc740 \ud558\ub8e8\u00a024<\/span>\uc2dc\uac04 \uc8fc\uae30\ub85c \uc0dd\ub9ac\ud65c\uc131\uc744 \uc870\uc808\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1c\uacac\ud55c \uac83\uc774\ub2e4.\u00a0<\/span>\ub4dc \uba54\ub791\uc740 \uc2dd\ubb3c\uc758 \ub0b4\ubd80\uc5d0 \ud558\ub8e8 \uc8fc\uae30\uc758 \ub9ac\ub4ec,\u00a0<\/span>\uc989 \uc77c\uc8fc\ub9ac\ub4ec(circadian rhythm)<\/span>\uc744 \uad00\uc7a5\ud558\ub294 \uc0dd\uccb4\uc2dc\uacc4\uac00 \uc788\ub2e4\uace0 \uacb0\ub860 \ub0b4\ub838\ub2e4.\u00a0<\/span><\/p>\n

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1729\ub144 \uc7a5-\uc790\ud06c \ub3c4\ub974\ud22c \ub4dc \uba54\ub791\uc740 \ub0ae\uc5d0\ub294 \uc78e\uc744 \ud3bc\uce58\uace0 \ubc24\uc5d0\ub294 \uc811\ub294 \ubbf8\ubaa8\uc0ac\ub97c \ud558\ub8e8 \uc885\uc77c \uc5b4\ub460 \uc18d\uc5d0 \ub450\uc5b4\ub3c4 \uc774\uc804 \ub0ae\uc5d0 \ud574\ub2f9\ud558\ub294 \uc2dc\uac04\ub300\uc5d0\ub294 \uc78e\uc744 \ud3bc\uce58\uace0 \ubc24 \uc2dc\uac04\uc774 \ub418\uba74 \uc811\ub294 \ud328\ud134\uc744 \ud55c\ub3d9\uc548 \uc9c0\uc18d\ud558\ub294 \ud604\uc0c1\uc744 \ubc1c\uacac\ud588\ub2e4. \ub4dc \uba54\ub791\uc740 \uc2dd\ubb3c\uc758 \ub0b4\ubd80\uc5d0 \uc77c\uc8fc\ub9ac\ub4ec\uc744 \uad00\uc7a5\ud558\ub294 \uc0dd\uccb4\uc2dc\uacc4\uac00 \uc788\ub2e4\uace0 \uacb0\ub860 \ub0b4\ub838\ub2e4. (\uc81c\uacf5 \ub178\ubca8\uc7ac\ub2e8 )<\/span><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\ucd08\ud30c\ub9ac \uc0dd\uccb4\uc2dc\uacc4 \ub3cc\uc5f0\ubcc0\uc774 \ub9cc\ub4e4\uc5b4<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc774\ub85c\ubd80\ud130\u00a0242<\/span>\ub144\uc774 \uc9c0\ub09c\u00a01971<\/span>\ub144,\u00a0<\/span>\ud559\uc220\uc9c0\u00a0\u2018<\/span>\ubbf8\uad6d\ub9bd\uacfc\ud559\uc6d0\ud68c\ubcf4\u2019<\/span>\uc5d0\ub294 \uc0dd\uccb4\uc2dc\uacc4\uac00 \uace0\uc7a5 \ub09c \ucd08\ud30c\ub9ac \ub3cc\uc5f0\ubcc0\uc774\uccb4\ub97c \ubcf4\uace0\ud55c \ub17c\ubb38\uc774 \uc2e4\ub838\ub2e4.\u00a0<\/span>\ubbf8\uad6d \uce7c\ud14d\uc758 \uc2dc\ubaa8\uc5b4 \ubca4\uc800 \uad50\uc218\uc640 \ub300\ud559\uc6d0\uc0dd \ub85c\ub110\ub4dc \ucf54\ub189\uce74\ub294\u00a0DNA<\/span>\ub97c \uc190\uc0c1\uc2dc\ud0a4\ub294 \uc57d\ubb3c\uc744 \ucc98\ub9ac\ud574 \uc5bb\uc740 \ub3cc\uc5f0\ubcc0\uc774 \ucd08\ud30c\ub9ac \uc218\ucc9c \ub9c8\ub9ac\uc5d0\uc11c \ub0b4\ubd80 \uc0dd\uccb4\uc2dc\uacc4\uac00 \uace0\uc7a5 \ub09c \uc138 \uc885\ub958\uc758 \ucd08\ud30c\ub9ac\ub97c \ubc1c\uacac\ud588\ub2e4.\u00a0<\/span>\ud558\ub098\ub294 \uc0dd\uccb4\uc2dc\uacc4\uac00 \uc644\uc804\ud788 \ub9dd\uac00\uc84c\uace0 \ud558\ub098\ub294 \ud558\ub8e8\uc758 \uc8fc\uae30\uac00\u00a019<\/span>\uc2dc\uac04\uc73c\ub85c \uc9e7\uc544\uc84c\uace0 \ub098\uba38\uc9c0 \ud558\ub098\ub294\u00a028<\/span>\uc2dc\uac04\uc73c\ub85c \uae38\uc5b4\uc84c\ub2e4.\u00a0<\/span><\/p>\n

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1971\ub144 \ubbf8\uad6d \uce7c\ud14d\uc758 \uc2dc\ubaa8\uc5b4 \ubca4\uc800 \uad50\uc218(\uc67c\ucabd)\uacfc \ub300\ud559\uc6d0\uc0dd \ub85c\ub110\ub4dc \ucf54\ub189\uce74(\uc624\ub978\ucabd)\ub294 \uc6b0\ud654(\u7fbd\u5316. \uace0\uce58\uc5d0\uc11c \uc131\ucda9\uc774 \ub098\uc624\ub294 \uacfc\uc815) \uc8fc\uae30\ub97c \uc0c1\uc2e4\ud55c \ucd08\ud30c\ub9ac \ub3cc\uc5f0\ubcc0\uc774\uccb4 \uc138 \uc885\uc744 \ubcf4\uace0\ud574 \ud604\ub300 \uc0dd\uccb4\uc2dc\uacc4 \uc5f0\uad6c\uc758 \ubb38\uc744 \uc5f4\uc5c8\ub2e4. \ubca4\uc800\ub294 2007\ub144 86\uc138\uc5d0, \ucf54\ub189\uce74\ub294 2015\ub144 68\uc138\uc5d0 \uc138\uc0c1\uc744 \ub5a0\ub0ac\ub2e4. (\uc81c\uacf5 Harris WA & \u2018\uc140\u2019)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\uc774\ub4e4\uc740 \uc5fc\uc0c9\uccb4 \uc9c0\ub3c4 \ubd84\uc11d\uc744 \ud1b5\ud574 \uc14b \ubaa8\ub450 \ub3d9\uc77c\ud55c \uc720\uc804\uc790\uac00 \uace0\uc7a5 \ub09c \uacb0\uacfc\ub77c\uace0 \uc8fc\uc7a5\ud558\uba74\uc11c \uc774 \uc720\uc804\uc790\ub97c\u00a0\u2018<\/span>\ud53c\ub9ac\uc5b4\ub4dc(period.\u00a0<\/span>\uc774\ud558\u00a0per)\u2019<\/span>\ub77c\uace0 \ubd88\ub800\ub2e4.\u00a0<\/span>\ub367\ubd99\uc5ec \uc0dd\uccb4\uc2dc\uacc4\uac00 \ub9dd\uac00\uc9c4 \uac74 \uc720\uc804\uc790 \uc911\uac04\uc774 \uc885\uacb0\ucf54\ub3c8\uc73c\ub85c \ubc14\ub00c\uc5b4 \ud574\ub2f9 \ub2e8\ubc31\uc9c8\uc774 \ud1a0\ub9c9 \ub098 \uae30\ub2a5\uc744 \uc783\uc740 \uacb0\uacfc\uc774\uace0,\u00a0<\/span>\uc8fc\uae30\uac00 \uc9e7\uc544\uc9c0\uac70\ub098 \uae38\uc5b4\uc9c4 \uac74 \uc911\uac04\uc5d0 \ub2e4\ub978 \uc544\ubbf8\ub178\uc0b0\uc73c\ub85c \ubc14\ub00c\uba74\uc11c \ub2e8\ubc31\uc9c8 \ud65c\uc131\uc774 \ubc14\ub010 \uacb0\uacfc\ub77c\uace0 \ucd94\uce21\ud588\ub2e4.<\/span><\/p>\n

13<\/span>\ub144\uc774 \uc9c0\ub09c\u00a01984<\/span>\ub144 \ubbf8\uad6d \ube0c\ub79c\ub2e4\uc774\uc2a4\ub300\uc758 \uc81c\ud504\ub9ac \ud640 \uad50\uc218\uc640 \ub9c8\uc774\ud074 \ub85c\uc2a4\ubc14\uc26c \uad50\uc218 \uacf5\ub3d9\uc5f0\uad6c\ud300\uacfc \ub85d\ud3a0\ub7ec\ub300 \ub9c8\uc774\ud074 \uc601 \uad50\uc218\ud300\uc774 \uac01\uac01 \ub3c5\ub9bd\uc801\uc73c\ub85c\u00a0per\u00a0<\/span>\uc720\uc804\uc790 \uc0ac\ub0e5\uc5d0 \uc131\uacf5\ud588\ub2e4.\u00a0<\/span>\uc601 \uad50\uc218\ud300\uc740\u00a01987<\/span>\ub144 \uc138 \uc885\uc758 \ub3cc\uc5f0\ubcc0\uc774\uccb4 \uac01\uac01\uc5d0\uc11c\u00a0per\u00a0<\/span>\uc720\uc804\uc790\uc758 \uc5b4\ub514\uac00 \uace0\uc7a5\uc774 \ub0ac\ub294\uac00\ub97c \ubc1d\ud600\ub0c8\ub294\ub370,\u00a0<\/span>\ubca4\uc800\uc640 \ucf54\ub189\uce74\uac00\u00a01971<\/span>\ub144 \ub17c\ubb38\uc5d0\uc11c \uc608\uc0c1\ud55c \uadf8\ub300\ub85c\uc600\ub2e4.
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\n1997<\/span>\ub144 \uc0dd\uc950\uc640 \uc0ac\ub78c\uc5d0\uc11c\ub3c4 \ucd08\ud30c\ub9ac\uc758\u00a0per<\/span>\uc5d0 \ud574\ub2f9\ud558\ub294 \uc720\uc804\uc790\uac00 \uc788\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ubc1d\ud600\uc84c\ub2e4.\u00a0<\/span>\uc989\u00a07<\/span>\uc5b5 \ub144 \uc804 \uacf5\ud1b5\uc870\uc0c1\uc5d0\uc11c \uac08\ub77c\uc9c4 \ubb34\ucc99\ucd94\ub3d9\ubb3c\uacfc \ucc99\ucd94\ub3d9\ubb3c\uc774 \uc0dd\uccb4\uc2dc\uacc4 \uc720\uc804\uc790\ub97c \uacf5\uc720\ud558\uace0 \uc788\ub2e4\ub294 \ub9d0\uc774\ub2e4.<\/span><\/p>\n

\ud55c\ud3b8, 1994<\/span>\ub144 \ud558\ub8e8\u00a028<\/span>\uc2dc\uac04 \uc8fc\uae30\ub97c \ubcf4\uc774\ub294 \ub3cc\uc5f0\ubcc0\uc774 \uc0dd\uc950\uac00 \ub098\uc654\ub2e4.\u00a0<\/span>\ud558\ub8e8 \uc8fc\uae30\uc758 \ubcc0\ud654\ub294 \ud074\ub7ed(Clock)\u00a0<\/span>\uc774\ub77c\ub294 \uc720\uc804\uc790\uac00 \uace0\uc7a5\ub098 \uc0dd\uae30\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4.\u00a0<\/span>\uc774\ubc88\uc5d4 \uac70\uafb8\ub85c \ucd08\ud30c\ub9ac\uc5d0\uc11c \ud574\ub2f9 \uc720\uc804\uc790\ub97c \ucc3e\uc558\ub2e4.\u00a0<\/span><\/p>\n

21<\/span>\uc138\uae30 \uac8c\ub188\uc2dc\ub300\ub97c \ub9de\uc544 \uc0dd\uccb4\uc2dc\uacc4 \uc720\uc804\uc790 \uc5f0\uad6c\ub3c4 \uae09\uc9c4\uc804\ud588\uace0 \uc774\uc81c \uc0dd\uccb4\uc2dc\uacc4\uac00 \uc5b4\ub5bb\uac8c \ub3cc\uc544\uac00\ub294\uc9c0\uc5d0 \ub300\ud55c \ub300\ub7b5\uc801\uc778 \uadf8\ub9bc\uc774 \uc644\uc131\ub410\ub2e4.\u00a0<\/span>\ud3ec\uc720\ub958\uc758 \uacbd\uc6b0\u00a0CLOCK\u00a0<\/span>\ub2e8\ubc31\uc9c8\uacfc\u00a0BMAL1<\/span>\uc774\ub77c\ub294 \ub2e8\ubc31\uc9c8\uc774 \uc9dd\uc744 \uc774\ub8e8\uc5b4\u00a0Per<\/span>\uacfc\u00a0Cry<\/span>\ub77c\ub294 \uc720\uc804\uc790\uc758 \ubc1c\ud604\uc744 \uc870\uc808\ud558\uace0 \ub9cc\ub4e4\uc5b4\uc9c4\u00a0Per1<\/span>\uacfc\u00a0Cry\u00a0<\/span>\ub2e8\ubc31\uc9c8\uc774 \ub2e4\uc2dc\u00a0CLOCK<\/span>\uacfc\u00a0BMAL1<\/span>\uc758 \ub2e8\ubc31\uc9c8\uc744 \uc870\uc808\ud558\ub294 \uc0c1\ud638\uc791\uc6a9\uc744 \ud1b5\ud574\u00a024<\/span>\uc2dc\uac04\uc744 \uc778\uc9c0\ud558\ub294 \uc0dd\uccb4 \ub9ac\ub4ec\uc744 \ub9cc\ub4e4\uc5b4\ub0b8\ub2e4.\u00a0<\/span>\uc989 \uc804\uc790\uac00 \ud6c4\uc790\ub97c \ucd09\uce5c\ud558\uace0(positive effect)\u00a0<\/span>\ud6c4\uc790\uac00 \uc804\uc790\ub97c \uc5b5\uc81c\ud558\ub294(negative effect)\u00a0<\/span>\ucd09\uc9c4–<\/span>\uc5b5\uc81c \ud68c\ub85c(positive-negative feedback)<\/span>\ub2e4.\u00a0<\/span>\uadf8\ub9ac\uace0 \ud3ec\uc720\ub958\uc5d0\uc11c\ub294 \ub1cc\uc758 \uc2dc\uc0c1\ud558\ubd80\uc5d0 \uc788\ub294 \uc2dc\uc2e0\uacbd\uad50\ucc28\uc0c1\ud575(SCN)<\/span>\uc5d0\uc11c \uc77c\uc8fc\ub9ac\ub4ec\uc744 \uad00\uc7a5\ud558\uc5ec \ub2e4\ub978 \uae30\uad00\ub4e4\uc758 \uc0dd\uccb4 \ub9ac\ub4ec\uc744 \uc870\uc808\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ubc1d\ud600\uc84c\ub2e4.\u00a0<\/span><\/p>\n

\uc0dd\uccb4\uc2dc\uacc4 \uc5f0\uad6c\uac00\ub4e4\uc758 \ubc18\uc138\uae30 \uac00\uae4c\uc6b4 \ub178\ub825\uc740 \uc9c0\ub09c\ud574 \ub178\ubca8\uc0dd\ub9ac\uc758\ud559\uc0c1 \uc218\uc0c1\uc73c\ub85c \uacb0\uc2e4\uc744 \ub9fa\uc5c8\ub2e4.\u00a0<\/span>\uc989\u00a01984<\/span>\ub144\u00a0per\u00a0<\/span>\uc720\uc804\uc790\ub97c \uaddc\uba85\ud55c \uc138 \uc0ac\ub78c\uc774 \uc0c1\uc744 \ubc1b\uc558\ub2e4.\u00a0<\/span>\ud604\ub300 \uc0dd\uccb4\uc2dc\uacc4 \uc5f0\uad6c\uc758 \ubb38\uc744 \uc5f0 \ubca4\uc800\uc640 \ucf54\ub189\uce74\ub294 \uc548\ud0c0\uae5d\uac8c\ub3c4 \uac01\uac01\u00a02007<\/span>\ub144\uacfc\u00a02015<\/span>\ub144 \uc138\uc0c1\uc744 \ub5a0\ub0ac\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc0dd\uccb4\uc2dc\uacc4\uc758 \uc874\uc7ac\ub97c \uac00\uc7a5 \uba3c\uc800 \ub4dc\ub7ec\ub0b8 \uc2dd\ubb3c \uc5ed\uc2dc \ube44\uc2b7\ud55c \uc2dc\uae30\uc5d0 \uad00\ub828 \uc720\uc804\uc790\ub4e4\uc774 \uc5ec\ub7ff \ubc1c\uacac\ub410\uace0 \ub3d9\ubb3c\uacfc \ube44\uc2b7\ud55c \uc0dd\uccb4\uc2dc\uacc4 \ud68c\ub85c \ubaa8\ub378\uc774 \uc81c\uc2dc\ub410\ub2e4.\u00a0<\/span>\ub300\ud45c\uc801\uc73c\ub85c \uc0dd\uccb4 \uc2dc\uacc4\uc5d0 \uad00\uc5ec\ud558\ub294 \uc720\uc804\uc790\u00a03<\/span>\uc778\ubc29\uc778\u00a0TOC1, CCA1, LHY<\/span>\uc758 \ubaa8\ub378\uc774\ub2e4.\u00a0<\/span>\uc544\uce68\uc5d0 \uc720\uc804\uc790\uc758 \ubc1c\ud604\uc774 \uc655\uc131\ud55c\u00a0CCA1<\/span>\uacfc\u00a0LHY<\/span>\uac00 \ud55c \uc30d\uc774\uace0 \uc800\ub141\uc5d0 \ubc1c\ud604\uc774 \uc655\uc131\ud55c\u00a0TOC1<\/span>\uc774 \ud575\uc2ec\uc73c\ub85c,\u00a0<\/span>\uc804\uc790\uac00 \ud6c4\uc790\ub97c \uc5b5\uc81c\ud558\uace0 \ud6c4\uc790\uac00 \uc804\uc790\ub97c \ucd09\uc9c4\ud55c\ub2e4\uace0 \uc54c\ub824\uc838 \uc788\uc5c8\ub2e4.<\/span><\/p>\n

\uadf8\ub7ec\ub098\u00a02012<\/span>\ub144\u00a0TOC1\u00a0<\/span>\uc5ed\uc2dc\u00a0CCA1<\/span>\uacfc\u00a0LHY<\/span>\ub97c \uc5b5\uc81c\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ubc1d\ud600\uc84c\ub2e4. 3<\/span>\uac1c\uc758 \uc720\uc804\uc790 \uc0ac\uc774\uc758 \ub124\ud2b8\uc6cc\ud06c\ub294 \uc5b5\uc81c–<\/span>\uc5b5\uc81c \ud68c\ub85c\uc778 \uc148\uc778\ub370,\u00a0<\/span>\uc5f0\uad6c \uacb0\uacfc \uc2e4\uc81c \uc704\uc758\u00a03<\/span>\uc778\ubc29 \uc678\uc5d0\ub3c4 \ub9ce\uc740 \uc720\uc804\uc790\ub4e4\uc774 \uc0dd\uccb4\uc2dc\uacc4\uc5d0 \uad00\uc5ec\ud574\u00a024<\/span>\uc2dc\uac04\uc758 \ub9ac\ub4ec\uc744 \ub9cc\ub4e4\uc5b4\ub0b8\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc54c \uc218 \uc788\uc5c8\ub2e4.\u00a0<\/span>\uc2dd\ubb3c\uc740 \uc774\ub3d9\uc131\uc774 \uc5c6\uae30 \ub54c\ubb38\uc5d0 \ud658\uacbd \ubcc0\ud654\uc5d0 \ubbfc\uac10\ud558\uac8c \ub300\ucc98\ud574\uc57c \ud558\uace0 \ub530\ub77c\uc11c \uc0dd\uccb4\uc2dc\uacc4\ub3c4 \ub354 \uc815\uad50\ud558\uac8c \uc870\uc808 \ub418\uc5b4\uc57c \ud558\ub294 \uac83\uc774\ub2e4.<\/span><\/p>\n

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\ub3d9\ubb3c(\uc0dd\uc950)\uacfc \uc2dd\ubb3c(\uc560\uae30\uc7a5\ub300)\uc758 \uc0dd\uccb4\uc2dc\uacc4 \ud68c\ub85c \ubaa8\ud615\uc774\ub2e4. \uc0dd\uc950 \uc0dd\uccb4\uc2dc\uacc4\ub294 PER \ub2e8\ubc31\uc9c8\uacfc CRY \ub2e8\ubc31\uc9c8\uc774 CLOCK \ub2e8\ubc31\uc9c8\uacfc BMAL1 \ub2e8\ubc31\uc9c8\uc744 \uc5b5\uc81c\ud558\uace0 \ud6c4\uc790\ub294 \uc804\uc790\ub97c \ucd09\uc9c4\ud558\ub294 \u2018\uc74c\uc131 \uc591\uc131 \ud53c\ub4dc\ubc31\u2019\uc744 \uc911\uc2ec\uc73c\ub85c \uc774\ub904\uc838 \uc788\ub2e4(\uc67c\ucabd). \ubc18\uba74 \uc560\uae30\uc7a5\ub300 \uc0dd\uccb4\uc2dc\uacc4\ub294 \uaf64 \ubcf5\uc7a1\ud55c\ub370, CCA1\uacfc LHY \uc30d\uacfc TOC1\uc774 \uc11c\ub85c\ub97c \uc5b5\uc81c\ud55c\ub2e4. \uadf8\ub9bc \uc624\ub978\ucabd \uc544\ub798\ub97c \ubcf4\uba74 \uc790\uc774\uac90\ud2f0\uc544(GI)\uac00 ZTL\uc744 \ub3c4\uc640 TOC1\uc744 \ubd84\ud574\ud558\ub294 \uc5ed\ud560\uc744 \ud568\uc744 \uc54c \uc218 \uc788\ub2e4. (\uc81c\uacf5 \u2018\uc720\ub7fd\uc0dd\ub9ac\ud559\uc800\ub110\u2019 & \u2018\uc2dd\ubb3c\uacfc\ud559\uacbd\ud5a5\u2019)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\uc30d\ub5a1\uc78e\uc2dd\ubb3c\uc758 \ubaa8\ub378\uc778 \uc560\uae30\uc7a5\ub300\uc758 \uacbd\uc6b0 \uc804\uccb4 \uc720\uc804\uc790\uc758\u00a03<\/span>\ubd84\uc758\u00a01\u00a0<\/span>\uc815\ub3c4\uac00 \uc0dd\uccb4\uc2dc\uacc4\uc758 \uc601\ud5a5\uc744 \ubc1b\uc544 \ubc1c\ud604\uc774 \uc77c\uc8fc\ub9ac\ub4ec\uc744 \ubcf4\uc774\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4.\u00a0<\/span>\uc774\ub807\ub4ef \uc2dd\ubb3c\uc740 \uc0dd\uccb4\uc2dc\uacc4 \uc870\uc808\uc5d0 \ub9ce\uc740 \uc5d0\ub108\uc9c0\ub97c \uc3df\uc544 \ud658\uacbd\uc758 \ubcc0\ud654\uc5d0 \ub9de\ucdb0 \ud6a8\uc728\uc801\uc73c\ub85c \uc0b4\uc544\uac04\ub2e4.\u00a0<\/span>\uc608\ub97c \ub4e4\uc5b4 \uad11\ud569\uc131 \uad00\ub828 \uc720\uc804\uc790\ub294 \ub0ae\uc5d0 \ubc1c\ud604\ud558\ub294 \uc8fc\uae30\ub97c \ubcf4\uc774\uac8c \uc124\uc815\ub3fc \uc788\uc5b4\uc57c \ud6a8\uc728\uc801\uc77c \uac83\uc774\ub2e4.\u00a0<\/span>\uc2e4\uc81c\ub85c\ub3c4 \uc815\uc624 \ubb34\ub835\uc5d0 \uc804\uc0ac\ubb3c\uc774 \uc815\uc810\uc744 \uce5c\ub2e4.\u00a0<\/span>\ubc18\uba74 \uc138\ud3ec\ubcbd \uc0dd\ud569\uc131 \uad00\ub828 \uc720\uc804\uc790\ub4e4\uc740 \ubc24\uc5d0 \ubc1c\ud604\ud55c\ub2e4.\u00a0<\/span><\/p>\n

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\uc720\uc804\uc790\uac00 \uace0\uc7a5 \ub098 \uc0dd\uccb4\uc2dc\uacc4 \uc8fc\uae30\uac00 \ubc14\ub00c\ub354\ub77c\ub3c4 \uc678\ubd80\ud658\uacbd\uc744 \ub9de\ucd94\uba74 \uc798 \uc790\ub784 \uc218 \uc788\ub2e4. \uc8fc\uae30\uac00 \uc9e7\uc544\uc9c4 \uc560\uae30\uc7a5\ub300 \ubcc0\uc774\uccb4(toc1-2)\uc640 \uae38\uc5b4\uc9c4 \ubcc0\uc774\uccb4(ztl-27)\ub97c \ud558\ub8e8\uac00 20\uc2dc\uac04(\ub0ae\uacfc \ubc24\uc774 \uac01\uac01 10\uc2dc\uac04)\uc778 \uc870\uac74\uc5d0 \ub450\uba74 toc1-2\uac00 \ub354 \uc798 \uc790\ub77c\uc9c0\ub9cc 28\uc2dc\uac04(\ub0ae\uacfc \ubc24\uc774 \uac01\uac01 14\uc2dc\uac04)\uc5d0\uc11c\ub294 ztl-27\uc774 \ub354 \uc798 \uc790\ub780\ub2e4. (\uc81c\uacf5 \u2018\uc0ac\uc774\uc5b8\uc2a4\u2019)<\/span><\/span><\/div>\n<\/div>\n

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\uc9c0\ub09c\u00a02005<\/span>\ub144 \ud559\uc220\uc9c0\u00a0\u2018<\/span>\uc0ac\uc774\uc5b8\uc2a4\u2019<\/span>\uc5d0\ub294 \uc2dd\ubb3c\uc758 \ub0b4\uc7ac\uc801 \uc0dd\uccb4\uc2dc\uacc4\uac00 \uc9c0\uad6c \uc790\uc804\uc73c\ub85c \uc778\ud55c \ubc24\ub0ae\uc758 \uc8fc\uae30\uc5d0 \ub300\ud55c \uc801\uc751\uc758 \uacb0\uacfc\uc784\uc744 \ubcf4\uc5ec\uc8fc\ub294 \ud765\ubbf8\ub85c\uc6b4 \uc5f0\uad6c\uacb0\uacfc\uac00 \uc2e4\ub838\ub2e4.\u00a0<\/span>\uc560\uae30\uc7a5\ub300\ub97c \ud558\ub8e8\uac00\u00a020<\/span>\uc2dc\uac04\uc73c\ub85c\u00a04<\/span>\uc2dc\uac04 \uc9e7\uc544\uc9c4 \ud658\uacbd\uacfc\u00a028<\/span>\uc2dc\uac04\uc73c\ub85c\u00a04<\/span>\uc2dc\uac04 \uae38\uc5b4\uc9c4 \ud658\uacbd\uc5d0 \ub450\uc790\u00a024<\/span>\uc2dc\uac04\uc77c \ub54c\uc5d0 \ube44\ud574 \ub2e8\uc704 \uba74\uc801 \ub2f9 \uc5fd\ub85d\uc18c\uc758 \uc591\uc774 \uc801\uc5c8\ub2e4.\u00a0<\/span>\ud55c\ud3b8\u00a0CCA1\u00a0<\/span>\uc720\uc804\uc790\uac00 \uc9c0\ub098\uce58\uac8c \ubc1c\ud604\ud574 \uc0dd\uccb4\uc2dc\uacc4\uac00 \uc791\ub3d9\ud558\uc9c0 \uc54a\ub294 \ub3cc\uc5f0\ubcc0\uc774 \uc560\uae30\uc7a5\ub300\ub3c4 \uc815\uc0c1\uc5d0 \ube44\ud574 \uc5fd\ub85d\uc18c\uac00 \uc801\uc5c8\ub2e4.
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\ud55c\ud3b8 \ub3cc\uc5f0\ubcc0\uc774\ub85c \uc0dd\uccb4\uc2dc\uacc4 \uc8fc\uae30\uac00 \ubc14\ub00c\ub354\ub77c\ub3c4 \uc678\ubd80\ud658\uacbd\uc774 \ud574\ub2f9 \uc8fc\uae30\uc5d0 \ub9de\ucdb0 \ubc14\ub00c\uba74 \uc798 \uc790\ub784 \uc218 \uc788\ub2e4.\u00a0<\/span>\uc608\ub97c \ub4e4\uc5b4 \uc790\uc774\ud2c0\ub8e8\ud504(ZTL)\u00a0<\/span>\uc720\uc804\uc790\uac00 \uace0\uc7a5 \ub09c \ubcc0\uc774\uccb4\ub294 \uc0dd\uccb4\uc2dc\uacc4 \uc8fc\uae30\uac00 \uae38\uc5b4\uc9c0\ub294\ub370,\u00a0<\/span>\uc2dd\ubb3c\uc5d0\uac8c\u00a028<\/span>\uc2dc\uac04\uc73c\ub85c \ub354 \uae38\uc5b4\uc9c4 \ud558\ub8e8 \ud658\uacbd\uc744 \ub9cc\ub4e4\uc5b4\uc8fc\uba74,\u00a0<\/span>\ud558\ub8e8\uac00\u00a020<\/span>\uc2dc\uac04\uc77c \ub54c\ubcf4\ub2e4 \uc5fd\ub85d\uc18c\ub97c \ub354 \ub9ce\uc774 \ub9cc\ub4e0\ub2e4.\u00a0<\/span>\ubc18\uba74\u00a0TOC1\u00a0<\/span>\uc720\uc804\uc790\uac00 \uace0\uc7a5 \ub09c \ubcc0\uc774\uccb4\ub294 \uc8fc\uae30\uac00 \uc9e7\uc544\uc9c0\ub294\ub370,\u00a0<\/span>\ubc18\ub300\ub85c \ud558\ub8e8\uac00\u00a028<\/span>\uc2dc\uac04\uc77c \ub54c\ubcf4\ub2e4\u00a020<\/span>\uc2dc\uac04\uc77c \ub54c\uc5d0 \ub354 \uc798 \uc790\ub780\ub2e4.\u00a0<\/span><\/p>\n

\uc9c0\ub09c\u00a02016<\/span>\ub144 \ubbf8\uad6d \ub370\uc774\ube44\uc2a4 \uce98\ub9ac\ud3ec\ub2c8\uc544\ub300 \uc5f0\uad6c\uc790\ub4e4\uc740 \ud574\ubc14\ub77c\uae30\uc758 \uc904\uae30 \ub05d\uc774 \ud0dc\uc591 \ube5b\uc744 \ud5a5\ud574 \uc790\ub77c\ub098\ub294 \ud5a5\uc77c\uc131\uc5d0\ub3c4 \uc0dd\uccb4\uc2dc\uacc4\uac00 \uad00\uc5ec\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1d\ud600\ub0c8\ub2e4.\u00a0<\/span>\uc904\uae30\uc758 \ucd95\uc774 \ud574\ub97c \ud5a5\ud574\uc57c \ubcf4\ud1b5 \uc904\uae30\uc640 \uc218\uc9c1 \ubc29\ud5a5\uc778 \uc78e\uc5d0\uc11c \ub2e8\uba74\uc801 \ub2f9 \ub354 \ub9ce\uc740 \ube5b\uc744 \ubc1b\uc744 \uc218 \uc788\ub2e4.\u00a0<\/span>\ub54c\ubb38\uc5d0 \uc2dd\ubb3c\uc740 \uc131\uc7a5\ud638\ub974\ubaac\uc778 \uc625\uc2e0\uc744 \uc774\uc6a9\ud55c\ub2e4.\u00a0<\/span>\uc989 \ub0ae\uc5d0\ub294 \uc904\uae30 \ub3d9\ucabd\uc5d0 \uc625\uc2e0\uc774 \ubab0\ub824 \uc138\ud3ec\ubd84\uc5f4\uc774 \ub9ce\uc774 \uc77c\uc5b4\ub098 \uc11c\ucabd\ubcf4\ub2e4 \uc131\uc7a5\uc774 \ube68\ub77c \uc904\uae30\uac00 \uc810\ucc28 \uc11c\ucabd\uc744 \ud5a5\ud558\uac8c \ub41c\ub2e4.\u00a0<\/span>\ubc24\uc5d0\ub294 \uc904\uae30 \uc11c\ucabd\uc758 \uc625\uc2e0 \ub18d\ub3c4\uac00 \ub192\uc544 \uc904\uae30\uac00 \ub2e4\uc2dc \ub3d9\ucabd\uc73c\ub85c \ud5a5\ud558\uac8c \ub41c\ub2e4.\u00a0<\/span>\uc591\ucabd \ub2e4\ub9ac\ub97c \ubc88\uac08\uc544 \ub0b4\ub514\ub514\uba70 \uc0ac\ub2e4\ub9ac\ub97c \uc624\ub974\ub4ef \ud574\ubc14\ub77c\uae30 \uc904\uae30\ub294 \ub3d9\uc11c\ub85c \ubc29\ud5a5\uc73c\ub85c \ubc14\uafd4\uac00\uba70 \ud0a4\uac00 \ucee4\uc9c0\ub294 \uac83\uc774\ub2e4.<\/span><\/p>\n

\uc5f0\uad6c\uc790\ub4e4\uc740 \ubc24\uc5d0\ub3c4 \uc625\uc2e0 \ub18d\ub3c4\uac00 \uc7ac\ubc30\uce58\ub41c\ub2e4\ub294 \uc0ac\uc2e4\uc5d0 \ucc29\uc548\ud574 \uc2dd\ubb3c\uc758 \ud5a5\uc77c\uc131\uc774 \ud587\ube5b\uc774 \uc544\ub2c8\ub77c \uc0dd\uccb4\uc2dc\uacc4\uc5d0 \uc758\ud574 \uc870\uc808\ub41c\ub2e4\uace0 \uac00\uc815\ud588\ub2e4.\u00a0<\/span>\uadf8\ub9ac\uace0 \uc774\ub97c \uc785\uc99d\ud558\uae30 \uc704\ud574 \ud558\ub8e8\uac00\u00a030<\/span>\uc2dc\uac04\uc778 \uc870\uac74\uc5d0\uc11c \ud574\ubc14\ub77c\uae30\ub97c \ud0a4\uc6e0\ub2e4.\u00a0<\/span>\uad00\ucc30 \uacb0\uacfc,\u00a0<\/span>\uc608\uc0c1\ub300\ub85c \uc904\uae30\uc758 \ud5a5\uc77c\uc131\uc774 \ubb34\ub108\uc838 \uc625\uc2e0\uc774 \uc7ac\ubc30\uce58\ub418\uc9c0 \ubabb\ud558\uace0 \ud574\ubc14\ub77c\uae30 \uaf43\uc758 \ubc29\ud5a5\uc740 \ubc14\ub00c\uc9c0 \uc54a\uc558\ub2e4.<\/span><\/p>\n

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\ud574\ubc14\ub77c\uae30\ub294 \uaf43\uc774 \ud53c\uae30 \uc804\uae4c\uc9c0 \uc131\uc7a5\ud560 \ub54c \uc904\uae30 \ub05d\uc774 \ub3d9\uc11c\ub85c \ud574\ubc14\ub77c\uae30\ub97c \ud55c\ub2e4. \uc989 \ud574 \uc9c8 \ubb34\ub835\uc5d0\ub294 \uc11c\ucabd\uc744 \ud5a5\ud558\uace0(\uc67c\ucabd) \uc790\uc815\uc5d0\ub294 \ubc14\ub85c \uc11c \uc788\uace0(\uac00\uc6b4\ub370) \ud574 \ub730 \ubb34\ub835\uc5d0\ub294 \ub3d9\ucabd\uc744 \ud5a5\ud55c\ub2e4(\uc624\ub978\ucabd). \uc5ec\uae30\uc5d0\ub294 \uc2dd\ubb3c\uccb4\uc758 \uc0dd\uccb4\uc2dc\uacc4\uac00 \uad00\uc5ec\ud558\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4. \u3000\u3000\u3000(\uc81c\uacf5 \u2018\uc0ac\uc774\uc5b8\uc2a4\u2019)<\/span><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc2dd\ubb3c\uc758 \uc0dd\uccb4\uc2dc\uacc4\ub294 \ub2e8\uc21c\ud788 \ud558\ub8e8 \uc8fc\uae30\ub9cc \uc778\uc2dd\ud558\ub294 \uac83\uc774 \uc544\ub2c8\ub2e4.\u00a0<\/span>\uacc4\uc808\uc5d0 \ub530\ub978 \ub0ae\uc758 \uae38\uc774 \ubcc0\ud654\ub3c4 \uac10\uc9c0\ud574 \uc801\uc808\ud558\uac8c \ub300\uc751\ud55c\ub2e4.\u00a0<\/span>\uadf8 \ub300\ud45c\uc801\uc778 \uc608\uac00 \uac1c\ud654\uc2dc\uae30 \uc870\uc808\uc774\ub2e4.\u00a0<\/span>\uc2dd\ubb3c\ub9c8\ub2e4 \uc815\ud574\uc9c4 \uc2dc\uae30\uc5d0 \uaf43\uc774 \ud53c\ub294 \uac78 \ubcf4\uba74 \uc774\ub97c \uc870\uc808\ud558\ub294 \uba54\ucee4\ub2c8\uc998\uc774 \uaf64 \uc815\uad50\ud568\uc744 \uc9d0\uc791\ud560 \uc218 \uc788\ub2e4.\u00a0<\/span>\uc608\ub97c \ub4e4\uc5b4 \uc560\uae30\uc7a5\ub300\ub294 \ud574\uac00 \uae38\uc5b4\uc9c0\ub294 \uc2dc\uae30\uc5d0 \uaf43\uc744 \ud53c\uc6b0\ub294 \uc7a5\uc77c\uc2dd\ubb3c\uc774\uace0,\u00a0<\/span>\ubcbc\ub294 \ud574\uac00 \uc9e7\uc544\uc9c0\ub294 \uac78 \uac10\uc9c0\ud574 \uaf43\uc774 \ud53c\ub294 \ub2e8\uc77c\uc2dd\ubb3c\uc774\ub2e4.<\/span><\/p>\n

\ub3d9\ubb3c \uc0dd\uccb4\uc2dc\uacc4 \ubd84\uc57c\uc5d0\uc11c\ub294 \uc6b0\ub9ac\ub098\ub77c \uacfc\ud559\uc790\uc758 \uc774\ub984\uc774 \ub208\uc5d0 \ub744\uc9c0 \uc54a\uc9c0\ub9cc \uc2dd\ubb3c \uc0dd\uccb4\uc2dc\uacc4 \ubd84\uc57c\uc5d0\uc11c\ub294 \ub9ce\uc740 \uad6d\ub0b4 \uacfc\ud559\uc790\ub4e4\uc774 \ud65c\uc57d\ud558\uace0 \uc788\uace0 \ud2b9\ud788 \uac1c\ud654\uc640 \uad00\ub828\ud574\uc11c\ub294 \ub180\ub77c\uc6b4 \uc131\uacfc\ub97c \uac70\ub480\ub2e4. IBS\u00a0<\/span>\uc2dd\ubb3c \ub178\ud654\u30fb\uc218\uba85 \uc5f0\uad6c\ub2e8 \ub0a8\ud64d\uae38 \ub2e8\uc7a5(DGIST\u00a0<\/span>\ub274\ubc14\uc774\uc62c\ub85c\uc9c0\uacfc \uc11d\uc88c\uad50\uc218)<\/span>\uc740 \uc774 \ubd84\uc57c\uc758\u00a0\u2018<\/span>\uac70\uc778\u2019<\/span>\uc774\ub2e4.<\/span><\/p>\n

\ub300\uac00(<\/span>\u5927\u5bb6)<\/span>\ub77c\ub294 \uc801\uc808\ud55c \ub2e8\uc5b4\ub97c \ub194\ub450\uace0 \ub2e4\uc18c \uc5b4\uc0c9\ud55c \uac70\uc778(<\/span>\u5de8\u4eba)<\/span>\uc774\ub77c\ub294 \ud45c\ud604\uc744 \uc4f4 \uac74 \ub0a8 \ub2e8\uc7a5\uc774 \uc77c\uc8fc\ub9ac\ub4ec\uacfc \uad11(<\/span>\u5149)<\/span>\uc8fc\uae30\uc131\uc5d0 \ub530\ub978 \uac1c\ud654\uc2dc\uae30\ub97c \uc870\uc808\ud558\ub294\ub370 \uad00\uc5ec\ud558\ub294 \uc720\uc804\uc790\u00a0<\/i>\u2018<\/i><\/span>\uc790\uc774\uac90\ud2f0\uc544(Gigantea)\u2019<\/span>\ub97c \uaddc\uba85\ud588\uae30 \ub54c\ubb38\uc774\ub2e4.\u00a0<\/span>\ub0a8 \ub2e8\uc7a5\uc740 \ud3ec\ud56d\uacf5\ub300 \uad50\uc218\ub85c \uc7ac\uc9c1 \uc911\uc774\ub358\u00a01999<\/span>\ub144 \ud559\uc220\uc9c0\u00a0\u2018<\/span>\uc0ac\uc774\uc5b8\uc2a4\u2019<\/span>\uc5d0 \uc774 \uacb0\uacfc\ub97c \ub2f4\uc740 \ub17c\ubb38\uc744 \uc2e4\uc5c8\ub294\ub370 \uc9c0\uae08\uae4c\uc9c0\u00a0540<\/span>\uc5ec \ud68c \uc778\uc6a9\ub410\ub2e4.
\n<\/span>
\n<\/span>\uc55e\uc11c \ucd08\ud30c\ub9ac\uc758 \ud53c\ub9ac\uc5b4\ub4dc \uc720\uc804\uc790\ucc98\ub7fc \uc790\uc774\uac90\ud2f0\uc544 \uc720\uc804\uc790 \uc5ed\uc2dc \uc774\ubbf8 \uc874\uc7ac\ud55c \ubcc0\uc774\uccb4 \uc2dd\ubb3c\uc758 \uc774\ub984\uc744 \uadf8\ub300\ub85c \uc4f4 \uac83\uc774\ub2e4.\u00a0\uc989\u00a01960\ub144\ub300 \ud55c \ub3cc\uc5f0\ubcc0\uc774 \uc560\uae30\uc7a5\ub300\uc5d0\u00a0\u2018\uac70\ub300\ud558\ub2e4\u2019\ub294 \ub73b\uc758 \ub77c\ud2f4\uc5b4 \uc774\ub984\uc744 \ubd99\uc600\ub2e4. 1970\ub144\ub300\u00a0x-\uc120\uc744 \ucabc\uc5ec \uc5bb\uc740 \uc560\uae30\uc7a5\ub300 \ub3cc\uc5f0\ubcc0\uc774\uccb4\ub4e4 \uc911,\u00a0\uaf43\uc774 \ub2a6\uac8c \ud53c\ub294 \ubc14\ub78c\uc5d0 \ub369\uce58\uac00 \ucee4\uc9c4 \ub450 \uac1c\uccb4\uac00 \uac19\uc740 \uc5fc\uc0c9\uccb4 \uc790\ub9ac\uc5d0 \ubcc0\uc774\uac00 \uc77c\uc5b4\ub09c \uac83\uc73c\ub85c \ubc1d\ud600\uc838 \uac01\uac01\u00a0gi-1\uacfc\u00a0gi-2\ub85c \uba85\uba85\ud588\ub2e4.<\/span><\/p>\n

\ub0a8 \uad50\uc218\ud300\uc740 \ub450 \ubcc0\uc774\uccb4\uc758 \uc5fc\uc0c9\uccb4\ub97c \ubd84\uc11d\ud574 \uc720\uc804\uc790\uc758 \uc2e4\uccb4\ub97c \ubc1d\ud788\ub294 \ub370 \uc131\uacf5\ud588\ub2e4.\u00a0\uc790\uc774\uac90\ud2f0\uc544(\uc774\ud558\u00a0GI)\u00a0\uc720\uc804\uc790\ub294 \uc544\ubbf8\ub178\uc0b0\u00a01173\uac1c\uc778 \ucee4\ub2e4\ub780 \ub2e8\ubc31\uc9c8\uc744 \uc9c0\uc815\ud558\uace0 \uc788\ub294\ub370,\u00a0\ub3d9\ubb3c\uc774\ub098 \ubbf8\uc0dd\ubb3c\uc5d0\ub294 \uc774\uc640 \ube44\uc2b7\ud55c \uc720\uc804\uc790\uac00 \uc5c6\ub2e4.\u00a0\uc989 \uc2dd\ubb3c\uc5d0 \ud2b9\ud654\ub41c \uc720\uc804\uc790\ub77c\ub294 \ub9d0\uc774\ub2e4.\u00a0\ubcc0\uc774\uccb4 \ubd84\uc11d \uacb0\uacfc\u00a0gi-1\uc740 \uc544\ubbf8\ub178\uc0b0\u00a0171\uac1c\uac00 \uc18c\uc2e4\ub41c\u00a0GI\u00a0\ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4dc\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\uace0, gi-2\uc5d0\uc11c\ub294 \ubd88\uacfc\u00a0158\uac1c\uc758 \uc544\ubbf8\ub178\uc0b0\uc73c\ub85c \uc774\ub904\uc9c4 \ub2e8\ubc31\uc9c8 \uc870\uac01\uc774 \ub9cc\ub4e4\uc5b4\uc9c0\ub294 \uac83\uc73c\ub85c \ud655\uc778\ub410\ub2e4.\u00a0\uc989\u00a0gi-1\uc5d0\uc11c\ub294 \ub2e8\ubc31\uc9c8 \uae30\ub2a5\uc774 \ubd88\uc644\uc804\ud560 \uac83\uc774\uace0\u00a0gi-2\uc5d0\uc11c\ub294 \uc544\uc608 \uae30\ub2a5\uc744 \ud558\uc9c0 \ubabb\ud560 \uac83\uc774\ub2e4.<\/p>\n

\uc5f0\uad6c\uc790\ub4e4\uc740\u00a0GI\u00a0\uc720\uc804\uc790\uc758 \uae30\ub2a5\uc744 \ucd94\uce21\ud558\uae30 \uc704\ud574\u00a0GI\u00a0\uc720\uc804\uc790\uac00 \uace0\uc7a5 \ub09c \ubcc0\uc774\uccb4\ub97c \uc790\uc138\ud788 \ub4e4\uc5ec\ub2e4\ubd24\ub2e4.\u00a0\uadf8 \uacb0\uacfc\u00a0GI\ub294 \uc0dd\uccb4\uc2dc\uacc4 \ud575\uc2ec \uc720\uc804\uc790\uc778\u00a0CCA1\uacfc\u00a0LHY\uc758 \ubc1c\ud604\uc5d0 \uc601\ud5a5\uc744 \uc8fc\uc5c8\ub2e4.\u00a0\uc774\ub7ec\ud55c \ud575\uc2ec \uc720\uc804\uc790\uc758 \ubcc0\ud654\ub294 \uc0dd\uccb4\uc2dc\uacc4 \ud45c\ud604\ud615 \uc911 \ud558\ub098\uc778 \uc78e \uc6c0\uc9c1\uc784\uc758 \uc8fc\uae30\ub97c \ud655\uc778\ud588\uc744 \ub54c \uc57c\uc0dd\ud615\uc774\u00a025.2\u00a0\uc2dc\uac04\uc744 \uac00\uc9c0\ub294 \ubc18\uba74\uc5d0\u00a0gi-1\uacfc\u00a0gi-2\uc5d0\uc11c\ub294 \uac01\uac01\u00a022.4\uc2dc\uac04\uacfc\u00a021.1\uc2dc\uac04\uc758 \uc8fc\uae30\ub97c \uac00\uc9c0\ub294 \uac83\uc744 \ud655\uc778\ud588\ub2e4.<\/p>\n

GI\u00a0\uc720\uc804\uc790\uc758 \uc2e4\uccb4\uac00 \ubc1d\ud600\uc9c0\uc790 \ub9ce\uc740 \uc5f0\uad6c\uc790\ub4e4\uc774 \uae30\ub2a5\uc744 \uaddc\uba85\ud558\ub294 \uc5f0\uad6c\uc5d0 \ub6f0\uc5b4\ub4e4\uc5c8\ub2e4.\u00a0\uadf8 \uacb0\uacfc\u00a0GI\uac00 \uc2dd\ubb3c \uc720\uc804\uc790 \ub124\ud2b8\uc6cc\ud06c\uc5d0\uc11c\u00a0\u2018\uc57d\ubc29\uc758 \uac10\ucd08\u2019\u00a0\uc5ed\ud560\uc744 \ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ubc1d\ud600\uc84c\ub2e4.\u00a0\uac1c\ud654\uc870\uc808\uc758 \uacbd\uc6b0\u00a0GI\u00a0\ub2e8\ubc31\uc9c8\uc740\u00a0FKF1\u00a0\ub2e8\ubc31\uc9c8\uacfc \ud300\uc744 \uc774\ub904 \uac1c\ud654\uc720\uc804\uc790 \ucf58\uc2a4\ud0c4\uc2a4(CO)\uc758 \ubc1c\ud604\uc744 \ub9c9\uace0 \uc788\ub294\u00a0CDF1\u00a0\ub2e8\ubc31\uc9c8\uc744 \ud30c\uad34\ud55c\ub2e4.\u00a0\uadf8 \uacb0\uacfc\u00a0CO\u00a0\uc720\uc804\uc790\uac00 \ubc1c\ud604\ud574 \uaf43\uc774 \ud540\ub2e4. FKF1\uc740 \ud30c\ub780\ube5b\uc744 \uc778\uc9c0\ud558\ub294 \ub2e8\ubc31\uc9c8\ub85c\u00a0GI\u00a0\ub2e8\ubc31\uc9c8\uacfc\u00a0FKF1\u00a0\ub2e8\ubc31\uc9c8\uc774 \ud300\uc744 \uc774\ub8e8\uae30 \uc704\ud574\uc11c\ub294 \ud30c\ub780\ube5b\uc774 \ud544\uc694\ud558\ub2e4. gi-1\uc774\ub098\u00a0gi-2\uc5d0\uc11c \uaf43\uc774 \ub2a6\uac8c \ud53c\ub294 \uc774\uc720\ub3c4\u00a0GI\u00a0\ub2e8\ubc31\uc9c8\uc774 \ubd80\uc2e4\ud558\uac70\ub098 \uae30\ub2a5\uc744 \ubabb\ud574\u00a0CO\u00a0\uc720\uc804\uc790\uac00 \uc81c\ub300\ub85c \ubc1c\ud604\ub418\uc9c0 \uc54a\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n

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\uc790\uc774\uac90\ud2f0\uc544(GI) \uc720\uc804\uc790\uc5d0\uc11c \uac01 \ub3cc\uc5f0\ubcc0\uc774\uccb4\ub4e4\uc758 DNA \uc190\uc0c1\uc774 \uc77c\uc5b4\ub09c \ubd80\uc704\ub97c \ubcf4\uc5ec\uc8fc\ub294 \uadf8\ub9bc\uc774\ub2e4. 1999\ub144 \ub0a8\ud64d\uae38 \uad50\uc218\ud300\uc740 gi-1\uc5d0\uc11c\ub294 4327~4331\ubc88\uc9f8 \uc5fc\uae30\uac00 \uc18c\uc2e4\ub410\uace0 gi-2\uc5d0\uc11c\ub294 670~677\ubc88\uc9f8 \uc5fc\uae30\uac00 \uc18c\uc2e4\ub3fc \uc0dd\uccb4\uc2dc\uacc4\uc640 \uac1c\ud654\uc2dc\uae30\uac00 \uc81c\ub300\ub85c \uc870\uc808\ub418\uc9c0 \uc54a\uc74c\uc744 \ud655\uc778\ud588\ub2e4. \uc587\uc740 \uc120\uc740 \ud504\ub85c\ubaa8\ud130\uc640 \uc778\ud2b8\ub860\uc774\uace0 \uad75\uc740 \uc120\uc740 \uc5d1\uc190\uc774\ub2e4. (\uc81c\uacf5 \u2018\uc2dd\ubb3c\uacfc\ud559\uacbd\uacc4\u2019)<\/span><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc138\ud3ec\ud575\uc5d0 \uc788\uc744 \ub54c\uc640 \uc138\ud3ec\uc9c8\uc5d0 \uc788\uc744 \ub54c \uc5ed\ud560 \ub2ec\ub77c<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc9c0\ub09c\u00a02013<\/span>\ub144\u00a03<\/span>\uc6d4 \ub0a8 \uad50\uc218\ud300\uc740\u00a0GI\u00a0<\/span>\ub2e8\ubc31\uc9c8\uc774 \ud2b9\uc774\ud55c \ud589\ud0dc\ub97c \ubcf4\uc774\ub294 \uc774\uc720\ub97c \uc54c\uc544\ub0b4 \ud559\uc220\uc9c0\u00a0\u2018<\/span>\uc140 \ub9ac\ud3ec\uce20\u2019<\/span>\uc5d0 \ubc1c\ud45c\ud588\ub2e4. GI\u00a0<\/span>\ub2e8\ubc31\uc9c8\uc740 \ub0ae\uc5d0\ub294 \uc138\ud3ec\ud575\uc5d0 \uace8\uace0\ub8e8 \ud37c\uc838 \uc788\uc9c0\ub9cc \ubc24\uc5d0\ub294 \ubb49\uccd0 \ud575\uccb4(nuclear body)<\/span>\ub97c \uc774\ub8e8\uace0 \uc788\ub2e4.\u00a0<\/span>\uc5f0\uad6c\uc790\ub4e4\uc740 \ubc24\uc5d0 \ub9ce\uc774 \ubc1c\ud604\ub418\ub294 \uc5d8\ud5044(ELF4)\u00a0<\/span>\ub2e8\ubc31\uc9c8\uc774 \uad00\uc5ec\ud574\u00a0GI\u00a0<\/span>\ub2e8\ubc31\uc9c8\uc744 \ud575\uccb4\ub85c \ubaa8\uc544\u00a0CO\u00a0<\/span>\uc720\uc804\uc790\uc5d0 \uc601\ud5a5\uc744 \uc8fc\uc9c0 \uc54a\uac8c \ud55c\ub2e4\uace0 \uc124\uba85\ud588\ub2e4.\u00a0<\/span>\uc989\u00a0GI\u00a0<\/span>\ub2e8\ubc31\uc9c8\uc774 \ubaa8\uc774\uace0 \ud769\uc5b4\uc9c0\ub294 \ud604\uc0c1\uc744 \ud1b5\ud574\u00a0CO\u00a0<\/span>\uc720\uc804\uc790\uc758 \ubc1c\ud604\uc744 \uc870\uc808\ud574 \uacb0\uad6d \uac1c\ud654\ub97c \uc870\uc808\ud558\ub294 \uac83\uc774\ub2e4.<\/span><\/p>\n

\ub109 \ub2ec\uc774 \uc9c0\ub09c\u00a02013<\/span>\ub144\u00a07<\/span>\uc6d4 \ub0a8 \uad50\uc218\ud300\uc740\u00a0\uc2dd\ubb3c\uc758 \uc138\ud3ec\uac00 \ubd88\uc548\uc815\ud55c \uc678\ubd80\ud658\uacbd(<\/span>\ube5b)<\/span>\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \uc548\uc815\uc801\uc778 \ubc18\uc751\uc744 \ubcf4\uc774\uac8c \ud558\ub294 \uc0dd\uccb4 \ud68c\ub85c\ub97c \ubc1d\ud600 \ud559\uc220\uc9c0\u00a0\u2018<\/span>\ub514\ubca8\ub85c\ud504\uba58\ud138 \uc140\u2019<\/span>\uc5d0 \ubc1c\ud45c\ud588\ub2e4.\u00a0<\/span>\uc138\ud3ec\ub0b4 \uc2e0\ud638 \uc870\uc808 \ud68c\ub85c\ub97c \uaddc\uba85\ud55c \uac83\uc778\ub370,\u00a0<\/span>\uc790\uc774\uac90\ud2f0\uc544(GI)<\/span>\uac00 \uc138\ud3ec\ud575\uacfc \uc138\ud3ec\uc9c8\u00a02<\/span>\uacf3\uc5d0 \uac01\uac01 \uc874\uc7ac\ud558\uba70 \uc11c\ub85c \ubc18\ub300\ub418\ub294 \uc870\uc808\uc2e0\ud638\ub97c \ubcf4\ub0b4 \uc0dd\uccb4 \ud68c\ub85c\uc758 \uc548\uc815\uc131\uc744 \uc720\ub3c4\ud558\ub294 \ud2b9\ubcc4\ud55c \uc815\ubcf4\ucc98\ub9ac \uae30\uc804\uc744 \uac00\uc84c\uc74c\uc744 \ud655\uc778\ud588\ub2e4.
\n<\/span>
\n<\/span>\ud575\uc5d0 \uc788\ub294\u00a0GI\ub294\u00a0LHY\ub97c \ud65c\uc131\ud654\uc2dc\ud0a4\uace0,\u00a0\uc138\ud3ec\uc9c8\uc5d0 \uc788\ub294\u00a0GI\ub294\u00a0LHY\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\ub294 \uac83\uc744 \uad00\ucc30\ud55c \uac83\uc774\ub2e4.\u00a0\ub610\ud55c \ud575\uacfc \uc138\ud3ec\uc9c8 \uc790\uc774\uac90\ud2f0\uc544\uac00 \uad6c\uc131\ud558\ub294 \uc870\uc808 \ud68c\ub85c\ub294 \uc678\ubd80 \ud658\uacbd\uc73c\ub85c\ubd80\ud130 \uc624\ub294 \uc2e0\ud638\uac00 \ubd88\uc548\uc815\ud558\ub354\ub77c\ub3c4 \uc2dd\ubb3c \uc138\ud3ec\uac00 \uc678\ubd80\uc5d0 \ud070 \uc601\ud5a5\uc744 \ubc1b\uc9c0 \uc54a\uace0 \uc548\uc815\uc801\uc73c\ub85c \ubc18\uc751\ud558\uac8c \ud558\ub294 \uac15\uac74\uc131\uc774 \uc788\uc74c\uc744 \ud655\uc778\ud588\ub2e4.<\/span><\/p>\n

\uc5f0\uad6c\uc9c4\uc740 \ud575\uc5d0 \uc788\ub294 \ub2e8\ubc31\uc9c8 \uc790\uc774\uac90\ud2f0\uc544\ub294 \uac1c\ud654 \uc2dc\uae30 \uc870\uc808\uacfc \uc2dd\ubb3c \ucd08\uae30 \uc0dd\uc7a5\uc5d0,\u00a0\uc138\ud3ec\uc9c8\uc5d0 \uc788\ub294 \ub2e8\ubc31\uc9c8 \uc790\uc774\uac90\ud2f0\uc544\ub294 \uc2dd\ubb3c \ucd08\uae30 \uc0dd\uc7a5\uacfc \uc0dd\uccb4\uc2dc\uacc4 \uc870\uc808\uc5d0 \uad00\uc5ec\ud558\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ud655\uc778\ud588\ub2e4.\u00a0\uadf8\ub3d9\uc548 \uc2dd\ubb3c\uc758 \uc138\ud3ec \ubd84\uc790\ub124\ud2b8\uc6cc\ud06c\ub294 \ub2e8\ubc31\uc9c8\uc758 \uc138\ud3ec \ub0b4 \ubd84\ud3ec \uc815\ubcf4\ub294 \uace0\ub824\ub418\uc9c0 \uc54a\uc740 \ucc44 \uc5f0\uad6c\ub418\uc5b4 \uc654\ub2e4.\u00a0\uc774\uc5d0 \uc5f0\uad6c\uc9c4\uc740 \uc138\ud3ec \ub0b4 \ubd84\uc790\ub124\ud2b8\uc6cc\ud06c\uac00 \ub2e8\ubc31\uc9c8\ub4e4\uc758 \uc138\ud3ec \ub0b4 \ubd84\ud3ec\ub97c \uc774\uc6a9\ud574 \uad6c\uc131\ub420 \uc218 \uc788\uc73c\uba70 \uc774\ub97c \ud1b5\ud574 \uc0dd\uccb4\ub85c \ub4e4\uc5b4\uc624\ub294 \uc2e0\ud638\ub97c \ud6a8\uacfc\uc801\uc73c\ub85c \ucc98\ub9ac\ud560 \uc218 \uc788\ub294 \ub2a5\ub825\uc774 \uc0dd\uae34\ub2e4\ub294 \uac83\uc744 \uc2dd\ubb3c \uc0dd\uccb4\uc2dc\uacc4 \uc0ac\ub840\ub85c \uc99d\uba85\ud558\uc600\ub2e4.<\/p>\n

GI\ub294 \uc0dd\uccb4\uc2dc\uacc4\ub098 \uac1c\ud654\uc2dc\uae30\ub97c \uc870\uc808\ud560 \ubfd0 \uc544\ub2c8\ub77c \ub179\ub9d0 \uc800\uc7a5,\u00a0\uc2a4\ud2b8\ub808\uc2a4(\uac00\ubb44,\u00a0\uc5fc\ubd84,\u00a0\uc800\uc628)\u00a0\ub300\uc751 \ub4f1 \ub2e4\uc591\ud55c \uc0dd\ub9ac\ud65c\ub3d9\uc5d0 \uad00\uc5ec\ud558\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4. GI\ub294 \uc2dd\ubb3c\uc758 \uc9c4\ud654\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud574\uc654\uc744 \uac83\uc774\ub2e4.\u00a0\uc55e\uc73c\ub85c\u00a0GI\uc758 \uc5b4\ub5a4 \ub610 \ub2e4\ub978 \ubaa8\uc2b5\uc774 \ub4dc\ub7ec\ub0a0\uc9c0 \uc9c0\ucf1c\ubcfc \uc77c\uc774\ub2e4.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

 <\/p>\n

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 <\/p>\n

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 <\/p>\n","protected":false},"excerpt":{"rendered":"

    (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~)   \uc2dd\ubb3c\uc740 \uc5b4\ub5bb\uac8c \uc2dc\uac04\uc744 \uc778\uc9c0\ud560\uae4c   \uc9c0\uae08\uc73c\ub85c\ubd80\ud130 \uac70\uc758\u00a0300\ub144 \uc804\uc778\u00a01729\ub144 \ud504\ub791\uc2a4 \ucc9c\ubb38\ud559\uc790 \uc7a5–\uc790\ud06c \ub3c4\ub974\ud22c \ub4dc \uba54\ub791\uc740 \ub0ae\uc5d0\ub294 \uc78e\uc744 \ud3bc\uce58\uace0 \ubc24\uc5d0\ub294 \uc811\ub294(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[33,29],"tags":[7,3],"class_list":["post-963","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","tag-do-biology","tag-lets-do-science"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":2617,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2617","url_meta":{"origin":963,"position":0},"title":"\u2018\ube5b\u2019\uc774\ub780 \ub3c4\ub300\uccb4 \ubb34\uc5c7\uc77c\uae4c?","author":"biochemistry","date":"February 6, 2019","format":false,"excerpt":"\u00a0 \u00a0 \uac70\uc6b8 \uc18d\uc5d0 \uc788\ub294 \uc790\uc2e0\uc758 \ubaa8\uc2b5\uc744 \ubcf4\uc790. \uac70\uc6b8 \uc18d\uc758 \ub098\ub3c4 \ub098\uc77c\uae4c? \ub2f9\uc5f0\ud788 \ub0b4\uac00 \uc544\ub2c8\ub2e4. \u00a0 \u00a0 \uc6b0\ub9ac\uac00\u00a0\uc624\ub978\uc190\uc744 \uc62c\ub9ac\uba74 \uac70\uc6b8 \uc18d \uce5c\uad6c\ub294 \uc67c\uc190\uc744 \uc62c\ub9b0\ub2e4. \uac70\uc6b8 \uc18d\uc758 \ub098\ub294 \ub0b4\uac00 \uc544\ub2c8\ub77c \ub098\uc758 \ube5b\uc774\ub2e4.\u00a0\ube5b\uc774\ub77c\ub294 \ud5c8\uc0c1\uc774\ub2e4. \ub3c4\ub300\uccb4 \uc5b4\ub5bb\uac8c \uac70\uc6b8 \ubc18\ub300\ud3b8\uc5d0 \ub098\uc640 \ub611\uac19\uc774 \uc0dd\uae34 \ube5b\uc774 \uc788\ub294 \uac78\uae4c? \ub2f9\uc5f0\ud788 \uc54c\uace0 \uc788\ub2e4\uace0 \uc0dd\uac01\ud588\ub294\ub370 \ub9c9\uc0c1 \ub2f5\ud558\uae30 \uace4\ub780\ud55c \uc9c8\ubb38\ub4e4\uc774\u2026","rel":"","context":"In "Let's Do Chemistry!"","block_context":{"text":"Let's Do Chemistry!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=34"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxOTAxMjVfMTU1\/MDAxNTQ4NDAwMzU2ODkz.8Fm5xxTH8jQ8Zg0gdK7sUR8uXMneubJewOIszyMOlNMg.iD3DLaV4JDNy2wEdg-2B2n941pKNQTIkerTgqhs3lfkg.JPEG\/01.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":2856,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2856","url_meta":{"origin":963,"position":1},"title":"\uad11\uc18d\uc73c\ub85c \ub2ec\ub9ac\ub294 \ube5b\uc740 \uc2dc\uac04\uc744 \uc5b4\ub5bb\uac8c \ub290\ub084\uae4c?","author":"biochemistry","date":"March 20, 2019","format":false,"excerpt":"\u00a0 \u00a0 . \ube5b\uc758 \uc18d\ub3c4\uc5d0 \uac00\uae4c\uc774 \ube60\ub974\uac8c \ubc29\ucd9c\ub418\ub294 \ube14\ub799\ud640\uc758 \uc81c\ud2b8 \uc774\ubbf8\uc9c0. \ubb3c\uccb4\uac00 \ube5b\uc758 \uc18d\ub3c4\uc5d0 \ub3c4\ub2ec\ud558\uba74 \uc2dc\uac04\uc774 \ub9e4\uc6b0 \uc774\uc0c1\ud558\uac8c \ubcc0\ud55c\ub2e4.(\ucd9c\ucc98=\u00a0NASA\/JPL-Caltech) \u00a0 \u00a0 \ube5b\uc740 \uc2dc\uac04\uc744 \uc5b4\ub5bb\uac8c \ub290\ub084\uae4c? \ube5b\ub3c4 \uc6b0\ub9ac\ucc98\ub7fc \ub299\uc744\uae4c? \uc774\uc5d0 \ub300\ud55c \ubb3c\ub9ac\ud559\uc790\uc758 \ud765\ubbf8\ub85c\uc6b4 \uce7c\ub7fc\uc774 16\uc77c(\ud604\uc9c0\uc2dc\uac04) \uc6b0\uc8fc\uc804\ubb38 \uc0ac\uc774\ud2b8 \uc2a4\ud398\uc774\uc2a4\ub2f7\ucef4\uc5d0 \ubc1c\ud45c\ub418\uc5c8\ub2e4. \uc544\ub798\uc758 \uae30\uc0ac\ub294 \ud574\ub2f9 \uce7c\ub7fc\uc744 \uc57d\uac04 \uc190\uc9c8\ud558\uc5ec \uc18c\uac1c\ud55c \uac83\uc774\ub2e4. \uc6c0\uc9c1\uc774\ub294 \uc2dc\uacc4\uc758 \uc2dc\uac04\uc740 \ub290\ub9ac\uac8c\u2026","rel":"","context":"In "Let's Do Physics!"","block_context":{"text":"Let's Do Physics!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=36"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3239,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3239","url_meta":{"origin":963,"position":2},"title":"\uc2a4\uc2a4\ub85c ‘\uc778\uad6c’\ub97c \uc870\uc808\ud558\ub294 \uc138\uade0\ub4e4","author":"biochemistry","date":"April 8, 2019","format":false,"excerpt":"\u00a0 \u00a0 \ub208\uc5d0\uc11c \ube5b\uc744 \ubfdc\ub294 \uc624\uc9d5\uc5b4 \ud558\uc640\uc774\uc5d0\ub294 \ub208\uc5d0\uc11c \ube5b\uc774 \ub098\ub294 \uc624\uc9d5\uc5b4\ub97c \ubcfc \uc218 \uc788\uc2b5\ub2c8\ub2e4. 1\ub144 \uc911 \ud558\uc640\uc774 \uc624\uc9d5\uc5b4\uac00 \ubaa8\uc774\ub294 \uc2dc\uae30\uac00 \ub418\uba74 \ubc24\ub9c8\ub2e4 \uc5c4\uccad\ub098\uac8c \ube5b\ub098\ub294 \uc7a5\uad00\uc744 \uc5f0\ucd9c\ud55c\ub2e4\uace0 \ud569\ub2c8\ub2e4. \ub3c4\ub300\uccb4 \ubb34\uc2a8 \uc77c\uc774 \ubc8c\uc5b4\uc9c0\ub294 \uac78\uae4c\uc694? 50\ub144 \uc804 \ubbf8\uad6d\uc758 \uc138\uade0\ud559\uc790 J. W. \ud5e4\uc774\uc2a4\ud305\uc2a4(J. W. Hastings) \ubc15\uc0ac\ub294 \uc774 \uc624\uc9d5\uc5b4\uc758 \ub208\uc5d0\uc11c \uc5b4\ub5bb\uac8c \ube5b\uc774 \ub098\ub294\uc9c0 \uc5f0\uad6c\ub97c \uc2dc\uc791\ud588\uc2b5\ub2c8\ub2e4.\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxOTAxMzBfNTgg\/MDAxNTQ4ODI0NzU0MTg2.EQTmVqqwHCB_pl-tXS529W2oQoJQuhlp33aKJQ_Q5MIg.RvFbJI4Bbyfw5HLf_7gZ8Tc_AOf0VaW0IuPugHU5-swg.JPEG\/4%ED%99%94_1.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":1896,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1896","url_meta":{"origin":963,"position":3},"title":"\ubd89\uc740 \ub2e8\ud48d\uc740 \ud2b9\ubcc4\ud558\ub2e4?! & \uac00\uc744\uc774\uba74 \uc6b8\uae0b\ubd88\uae0b\ud574\uc9c0\ub294 \ub098\ubb47\uc78e ‘\uc65c\uadf8\ub7f4\uae4c?’","author":"biochemistry","date":"September 27, 2018","format":false,"excerpt":"\u00a0 \u00a0 \uac00\uc744 \ub2e8\ud48d\uc5d0 \uad00\ud55c \ub3d9\uc601\uc0c1\uacfc \uc124\uba85\uc785\ub2c8\ub2e4. (\uc6d0\ubb38) \u00a0 \u00a0 \ubaa8\ub4e0 \uc2dd\ubb3c\uc758 \uc138\ud3ec\uc5d0\ub294 \uad11\ud569\uc131\uc744 \ud558\ub294 \uc5fd\ub85d\uc18c\uc640\u00a0\uad11\ud569\uc131\uc744 \ub3d5\ub294 \ubcf4\uc870\uc0c9\uc18c\uac00 \uc788\ub2e4.\u00a0\ub178\ub780\uc0c9\uc744 \ub760\ub294 \uce74\ub85c\ud2f0\ub178\uc774\ub4dc\uc640 \ud06c\uc0b0\ud1a0\ud544,\u00a0\ubd89\uc740\uc0c9\uc744 \ub760\ub294 \uc548\ud1a0\uc2dc\uc544\ub2cc \ubaa8\ub450 \ubcf4\uc870\uc0c9\uc18c\uc5d0 \uc18d\ud55c\ub2e4.\u00a0\ub2e8\ud48d\uc758 \uc0c9\uc740 \uc774 \ubcf4\uc870\uc0c9\uc18c \ub54c\ubb38\uc5d0 \ub098\ud0c0\ub09c\ub2e4. \ubcf4\uc870\uc0c9\uc18c \uc911\uc5d0\uc11c\ub3c4 \ubd89\uc740 \ube5b\uc744 \ub760\ub294 \uc548\ud1a0\uc2dc\uc544\ub2cc\uc740 \ud2b9\ubcc4\ud558\ub2e4.\u00a0\uce74\ub85c\ud2f0\ub178\uc774\ub4dc\ub294 \ubaa8\ub4e0 \uc2dd\ubb3c\uc774 \uac00\uc9c4 \ubcf4\uc870\uc0c9\uc18c\ub85c\u00a0\uadf8 \ud568\ub7c9\uc5d0 \ub530\ub77c \ub178\ub780 \ube5b\uc774 \uc5bc\ub9c8\ub098 \uc9c4\ud558\uac8c \ubcf4\uc774\ub290\ub0d0\uac00\u2026","rel":"","context":"In "'05. \ubb3c\uc9c8\uc758 \uc9c4\ud654' \uad00\ub828"","block_context":{"text":"'05. \ubb3c\uc9c8\uc758 \uc9c4\ud654' \uad00\ub828","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=41"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1228,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1228","url_meta":{"origin":963,"position":4},"title":"\ud574\ub9ac\ud3ec\ud130 \ud22c\uba85\ub9dd\ud1a0 \ud604\uc2e4\ud654\ub420\uae4c?","author":"biochemistry","date":"July 25, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 '\ubb3c\uc9c8 \uc131\uc9c8' \uc54c\uba74 \uc131\ub2a5\uc774 \ubcf4\uc778\ub2e4 \u00a0 \u00a0 \uc601\ud654\u2018\ud574\ub9ac\ud3ec\ud130\u2019\uc5d0\uc11c \uc8fc\uc778\uacf5 \ud574\ub9ac\ub294 \ud22c\uba85\ub9dd\ud1a0\ub97c \uc774\uc6a9\ud574 \ubab8\uc744 \uc228\uae34 \ucc44 \ub9c8\ubc95\ud559\uad50 \ud638\uadf8\uc640\ud2b8 \uacf3\uacf3\uc744 \ub204\ube44\uba70 \ube44\ubc00 \ub2e8\uc11c\ub97c \ucc3e\uae30\ub3c4 \ud558\uace0,\u00a0\uc218\ucc28\ub840 \uc704\uae30\uc5d0\uc11c \ubc97\uc5b4\ub098\uae30\ub3c4 \ud55c\ub2e4.\u00a0\uc601\ud654\ucc98\ub7fc \uc6b0\ub9ac\ub3c4 \ud0c0\uc778\uc758 \uc2dc\uc120\uc5d0\uc11c \ubc97\uc5b4\ub098\ub294 \uc790\uc720\ub97c \ub204\ub9ac\uace0 \ud5a5\uc720\ud558\uace0 \uc2f6\uc5b4 \ud55c\ub2e4.\u00a0\ub204\uad6c\ub098 \ud55c\ubc88\ucbe4 \uafc8\uafd4 \ubd24\uc744 \ub9c8\ubc95\uc758 \ud22c\uba85\ub9dd\ud1a0,\u00a0\uacfc\uc5f0 \ud604\uc2e4\uc801\uc73c\ub85c \uac00\ub2a5\ud560\uae4c? \u00a0 \u00a0 \uc601\ud654\u2026","rel":"","context":"In "'05. \ubb3c\uc9c8\uc758 \uc9c4\ud654' \uad00\ub828"","block_context":{"text":"'05. \ubb3c\uc9c8\uc758 \uc9c4\ud654' \uad00\ub828","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=41"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxODA3MTZfMTkx\/MDAxNTMxNzA0Nzg5MzEw.UZWB7e1G2neopeT-ibdcICbk4-JI-40bgBkXRk1F_SUg.QXKt97YQ0A1rTsihIEglTXRFzW95I4s0px44CuPsUh0g.PNG\/Untitled-1.png?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxODA3MTZfMTkx\/MDAxNTMxNzA0Nzg5MzEw.UZWB7e1G2neopeT-ibdcICbk4-JI-40bgBkXRk1F_SUg.QXKt97YQ0A1rTsihIEglTXRFzW95I4s0px44CuPsUh0g.PNG\/Untitled-1.png?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxODA3MTZfMTkx\/MDAxNTMxNzA0Nzg5MzEw.UZWB7e1G2neopeT-ibdcICbk4-JI-40bgBkXRk1F_SUg.QXKt97YQ0A1rTsihIEglTXRFzW95I4s0px44CuPsUh0g.PNG\/Untitled-1.png?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxODA3MTZfMTkx\/MDAxNTMxNzA0Nzg5MzEw.UZWB7e1G2neopeT-ibdcICbk4-JI-40bgBkXRk1F_SUg.QXKt97YQ0A1rTsihIEglTXRFzW95I4s0px44CuPsUh0g.PNG\/Untitled-1.png?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":1787,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1787","url_meta":{"origin":963,"position":5},"title":"\uc9c4\uc2e4\uc744 \ubb49\uac1c\ub294 \uac00\uc9dc\ub274\uc2a4\uac00 \ud310\uce58\ub294 \uc774\uc720","author":"biochemistry","date":"September 20, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) \u00a0 \u00a0 \uc0ac\uc774\uc5b8\uc2a4 \uc81c\uacf5 \u00a0 \ubd89\uc740 \ube5b \ubb34\ub9ac\uac00 \uc555\ub3c4\ud558\ub294 \uac00\uc6b4\ub370 \ucd08\ub85d\uc0c9 \ube5b\uc774 \uaca8\uc6b0 \uba85\ub9e5\uc744 \uc720\uc9c0\ud558\uace0 \uc788\ub2e4. 3\uc6d4 \ub458\uc9f8\uc8fc \uc0ac\uc774\uc5b8\uc2a4 \ud45c\uc9c0\ub97c \uc7a5\uc2dd\ud55c \ube5b \ubb34\ub9ac\ub294 \uc5b4\ub5a4 \uc758\ubbf8\ub97c \ub2f4\uace0 \uc788\ub294 \uac78\uae4c? '\uc5b4\ub5bb\uac8c \uac70\uc9d3\uc774 \uc720\ud1b5\ub418\ub294\uac00(How\u00a0lies\u00a0spread)'\ub77c\ub294 \uc81c\ubaa9\uacfc \uc5f0\uad00\uc9c0\uc5b4 \ubcf4\uba74, \uc774\ubc88 \ud45c\uc9c0\ub294 \uac70\uc9d3(\ubd89\uc740\uc0c9)\uc774 \uc9c4\uc2e4(\ucd08\ub85d\uc0c9)\uc744 \uc81c\uc555\ud55c \ub4a4 \ud37c\uc838\ub098\uac00\ub294 \ubaa8\uc2b5\uc744 \ud615\uc0c1\ud654\ud55c \uac83\uc73c\ub85c \ud574\uc11d\ub41c\ub2e4.\u2026","rel":"","context":"In "Essays on Science"","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_sharing_enabled":false,"jetpack_shortlink":"https:\/\/wp.me\/p9Xo1j-fx","_links":{"self":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/963","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=963"}],"version-history":[{"count":1,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/963\/revisions"}],"predecessor-version":[{"id":5648,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/963\/revisions\/5648"}],"wp:attachment":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=963"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=963"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=963"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}