{"id":955,"date":"2018-06-25T09:08:05","date_gmt":"2018-06-25T09:08:05","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=955"},"modified":"2019-10-15T18:51:50","modified_gmt":"2019-10-15T09:51:50","slug":"how-cells-imprison-viruses-in-molecular-cages","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=955","title":{"rendered":"How cells imprison viruses in molecular cages"},"content":{"rendered":"

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\"Vaccinia<\/div>\n<\/div>
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Vaccinia virus particles (pictured) can be immobilized \u2014 at least temporarily \u2014 by host cells. Credit: Dr Klaus Boller\/SPL<\/p>\n<\/figcaption><\/figure>\n

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How cells imprison viruses in molecular cages<\/h6>\n
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Corralled viruses escape by co-opting cellular proteins.<\/p>\n

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A protein cage that cells deploy to slow the spread of certain viruses could help scientists to develop better antiviral drugs.<\/p>\n

The vaccinia virus is a less-harmful relative of the smallpox virus. After vaccinia reproduces inside a host cell, some viral particles prompt components of the cell\u2019s internal skeleton to form \u2018tails\u2019 that protrude from the cell. Each tail has a viral particle at its tip. The tails propel the particles outwards, allowing the virus to cross into adjacent cells.<\/p>\n

Michael Way at the Francis Crick Institute in London and his colleagues imaged living human cells to investigate this process in more detail. The researchers found that cellular proteins called septins form \u2018cages\u2019 that trap the viral particles, delaying assembly of the tails. Vaccinia eventually breaks free by recruiting other cellular proteins that displace the septin cage, but the virus can be kept locked up by inhibiting these proteins.<\/p>\n

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J. Cell Biol.<\/i>\u00a0(2018)<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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    (\uc6d0\ubb38)       Vaccinia virus particles (pictured) can be immobilized \u2014 at least temporarily \u2014 by host cells. Credit: Dr Klaus Boller\/SPL(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[33,29,30],"tags":[7,3,4],"class_list":["post-955","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","category-recent-science-news","tag-do-biology","tag-lets-do-science","tag-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":404,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=404","url_meta":{"origin":955,"position":0},"title":"Cancer-killing viruses show promise \u2014 and draw billion-dollar investment","author":"biochemistry","date":"May 30, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 Encouraging trial results spur interest from researchers and drug giants. \u00a0 \u00a0 Researchers are trying to boost the effectiveness of cancer-killing viruses to treat conditions including brain tumours (red).Credit: Sherbrooke Connectivity Imaging Lab\/SPL \u00a0 Pharmaceutical giant Johnson & Johnson announced on 2 May that it\u2026","rel":"","context":"In "Essays on Science"","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3809,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3809","url_meta":{"origin":955,"position":1},"title":"The secret social lives of viruses","author":"biochemistry","date":"June 19, 2019","format":false,"excerpt":"\u00a0 \u00a0 Scientists are listening in on the ways viruses communicate and cooperate. Decoding what the microbes are saying could be a boon to human health. \u00a0 \u00a0 Illustration by Karol Banach \u00a0PDF version \u00a0 \u00a0 Geneticist Rotem Sorek could see that his bacteria were sick \u2014 so far, so\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":976,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=976","url_meta":{"origin":955,"position":2},"title":"CRISPR with a heart of gold helps ailing mice","author":"biochemistry","date":"June 28, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 \u00a0 Gene-editing molecules ride gold nanoparticles into the brain. \u00a0 Expression of a protein (blue-green, left) associated with fragile X syndrome is suppressed (right) in the brains of mice treated with CRISPR gene-editing molecules. Credit: B. 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Here we report the transcriptional profiles of 116,312 single cells from mouse embryos collected at nine sequential time points ranging from\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":951,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=951","url_meta":{"origin":955,"position":4},"title":"To make plastic, just add blood","author":"biochemistry","date":"June 25, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 \u00a0 Red blood cells contain the iron-based molecule haemoglobin, which has now been harnessed to synthesize plastic. 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Oakes\u00a0et al.\/Cell \u00a0 \u00a0 \u00a0 Engineered tweaks to the popular gene-editing system allow it to fight viral infection. \u00a0 A bacterial enzyme that researchers often use to\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_sharing_enabled":false,"jetpack_shortlink":"https:\/\/wp.me\/p9Xo1j-fp","_links":{"self":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/955","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=955"}],"version-history":[{"count":1,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/955\/revisions"}],"predecessor-version":[{"id":4384,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/955\/revisions\/4384"}],"wp:attachment":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=955"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=955"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=955"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}