{"id":953,"date":"2018-06-25T09:01:22","date_gmt":"2018-06-25T09:01:22","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=953"},"modified":"2019-10-15T18:51:06","modified_gmt":"2019-10-15T09:51:06","slug":"gene-important-in-pregnancy-shows-evolution-in-action","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=953","title":{"rendered":"Gene important in pregnancy shows evolution in action"},"content":{"rendered":"

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Childbirth and pregnancy might be influenced by variations in the progesterone-receptor gene, which shows wide diversity in humans. Credit: BSIP\/UIG\/Getty<\/p>\n<\/figcaption><\/figure>\n

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Gene important in pregnancy shows evolution in action<\/h6>\n
Human populations have different forms of a gene encoding a hormone receptor.<\/div>\n

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A pregnancy-related gene shows different forms in different human populations \u2014 a result of relatively recent evolution.<\/p>\n

Mutations in the gene\u00a0PGR<\/i>, which encodes a protein that senses the hormone progesterone, might be linked to preterm birth and ovarian cancer. A team led by David Stevenson and Gary Shaw at Stanford University School of Medicine in California examined variations in the\u00a0PGR<\/i>\u00a0gene in human groups from far-flung locales.<\/p>\n

The researchers found that East Asian groups carry many fewer versions of the gene than do Europeans, which indicates that the gene has continued to evolve since the split between the ancestors of these populations. This recent genetic change might have conferred protection against preterm birth. The study also traced a potentially harmful\u00a0PGR<\/i>\u00a0mutation to Neanderthal genomes, suggesting that humans acquired the mutation through interbreeding.<\/p>\n

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Am. J. Hum. Genet.<\/i>\u00a0(2018)<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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    (\uc6d0\ubb38)       Childbirth and pregnancy might be influenced by variations in the progesterone-receptor gene, which shows wide diversity in humans. Credit:(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[33,29,30],"tags":[7,3,4],"class_list":["post-953","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","category-recent-science-news","tag-do-biology","tag-lets-do-science","tag-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":842,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=842","url_meta":{"origin":953,"position":0},"title":"A simple test helps pinpoint a baby\u2019s arrival date","author":"biochemistry","date":"June 11, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Prenatal ultrasound is the gold standard for determining gestational age, but a blood test for placental RNA delivers comparable results. 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Rodriques\u00a0et al.\u00a0developed a method called Slide-seq, whereby RNA was spatially resolved from tissue sections by transfer onto a surface covered with DNA-barcoded beads. Applying Slide-seq to regions of a mouse brain revealed spatial gene expression\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1128,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1128","url_meta":{"origin":953,"position":3},"title":"Gene editing gets a head start","author":"biochemistry","date":"July 17, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) \u00a0 \u00a0 Science\u00a0\u00a013 Jul 2018: Vol. 361, Issue 6398, pp. 142 DOI: 10.1126\/science.361.6398.142-b \u00a0 \u00a0 The development of gene-editing technologies into therapies for human disease is an exciting prospect. 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