{"id":896,"date":"2018-06-16T02:25:53","date_gmt":"2018-06-16T02:25:53","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=896"},"modified":"2019-10-15T18:21:35","modified_gmt":"2019-10-15T09:21:35","slug":"tackling-microtubule-tau-interactions","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=896","title":{"rendered":"Tackling microtubule-tau interactions"},"content":{"rendered":"

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(\uc6d0\ubb38<\/a>)<\/p>\n

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Science\u00a0<\/cite>\u00a015 Jun 2018:
\nVol. 360, Issue 6394, pp. 1198-1200
\nDOI: 10.1126\/science.360.6394.1198-n<\/p>\n

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Alzheimer’s disease is a major cause of death in the elderly. Disease progression is associated with the accumulation of neurofibrillary tangles composed of tau, a protein important for neuronal development and function. Tangle formation is preceded by phosphorylation events that cause tau to dissociate from its native binding partner, microtubules. Microtubule-tau interactions have been mysterious. Kellogg\u00a0et al.<\/em>\u00a0used cryo\u2013electron microscopy and molecular modeling to show how tau interacts with the outer surface of the microtubule, stapling together tubulin subunits and thus stabilizing the polymer. A key tau amino acid within the tightly bound segment between tubulin subunits corresponds to a clinically relevant site of tau phosphorylation, explaining the competition between microtubule interaction and tau aggregation.<\/p>\n

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Science<\/em>, this issue p.\u00a01242<\/a><\/p>\n

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\n","protected":false},"excerpt":{"rendered":"

    (\uc6d0\ubb38)   Science\u00a0\u00a015 Jun 2018: Vol. 360, Issue 6394, pp. 1198-1200 DOI: 10.1126\/science.360.6394.1198-n     Alzheimer’s disease is a major cause of death(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[33,34,29,30],"tags":[7,8,3,4],"class_list":["post-896","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-chemistry","category-lets-do-science","category-recent-science-news","tag-do-biology","tag-lets-do-chemistry","tag-lets-do-science","tag-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":4728,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4728","url_meta":{"origin":896,"position":0},"title":"Toward synthetic cells","author":"biochemistry","date":"November 2, 2019","format":false,"excerpt":"\u00a0 \u00a0 An aspirational goal in cell biology is de novo synthesis of whole cells, with the expectation that this will reveal principles of spatiotemporal organization. Natural cells are defined by their boundaries, usually lipid bilayer plasma membranes stabilized by external cell walls or cytoskeletal cortices comprising actin. Typically, researchers\u2026","rel":"","context":"In "'05. \ubb3c\uc9c8\uc758 \uc9c4\ud654' \uad00\ub828"","block_context":{"text":"'05. \ubb3c\uc9c8\uc758 \uc9c4\ud654' \uad00\ub828","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=41"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1816,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1816","url_meta":{"origin":896,"position":1},"title":"A core problem in nuclear assembly","author":"biochemistry","date":"September 23, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 Chromosomes can exist outside the nucleus in rupture-prone structures called micronuclei. It emerges that micronuclei are fragile because their outer layer lacks some nuclear-envelope components. \u00a0 \u00a0 The genome sequencing of some cancer cells revealed the occurrence of large-scale DNA rearrangements that are characteristic of a\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4114,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4114","url_meta":{"origin":896,"position":2},"title":"Glowing DNA label illuminates a cell\u2019s fine details","author":"biochemistry","date":"September 23, 2019","format":false,"excerpt":"\u00a0 \u00a0 Fluorescent tag can be affixed to proteins or genetic structures of interest. \u00a0 \u00a0 DNA tags could help scientists to study ion channels (yellow), which allow specific ions to pass through the membrane of nerve cells (green). Credit: Patrick Landmann\/SPL \u00a0 \u00a0 \u00a0 A glowing tag made of\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2639,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2639","url_meta":{"origin":896,"position":3},"title":"Biomarkers for Alzheimer\u2019s disease beyond amyloid and tau","author":"biochemistry","date":"February 8, 2019","format":false,"excerpt":"\u00a0 \u00a0 Two new biomarkers for Alzheimer\u2019s disease include one in the blood that relates to neurodegeneration and another that reflects blood\u2013brain barrier dysfunction and is identifiable in cerebrospinal fluid analysis. \u00a0 Amyloid \u03b2 (A\u03b2) plaque and tau tangle pathology are hallmarks of Alzheimer\u2019s disease (AD), the commonest dementia, and\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4919,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4919","url_meta":{"origin":896,"position":4},"title":"Gene expression regulated by RNA stability","author":"biochemistry","date":"January 7, 2020","format":false,"excerpt":"\u00a0 \u00a0 One of the first discoveries of gene expression mediated by controlling messenger RNA (mRNA) stability is autoregulation of tubulin synthesis. In this regulatory process, the concentration of tubulin subunits modulates the stability of the mRNAs from which they are translated (1,\u00a02). In the 1980s it was found that\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1121,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1121","url_meta":{"origin":896,"position":5},"title":"Double trouble at the beginning of life","author":"biochemistry","date":"July 17, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) \u00a0 Science\u00a0\u00a013 Jul 2018: Vol. 361, Issue 6398, pp. 128-129 DOI: 10.1126\/science.aau3216 \u00a0 \u00a0 Every human life begins with the fertilization of an egg (1). Once the egg and the sperm have fused, the parental chromosomes need to be united. 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