![\"Young](\"https:\/\/media.nature.com\/w800\/magazine-assets\/d41586-018-05352-1\/d41586-018-05352-1_15820950.jpg\")
<\/div>\n<\/div>Koalas can be very picky about what kind of eucalyptus they eat.<\/span>Credit: Getty<\/p>\n<\/figcaption><\/figure>\n <\/p>\n Koalas are among the world\u2019s fussiest eaters, consuming only the leaves of eucalyptus trees \u2014 and just a few varieties of eucalyptus at that. Research now suggests that the animals\u2019 discriminating diet is determined in part by the bacteria that live in their guts, which seem to restrict an individual koala\u2019s ability to digest certain species of eucalyptus.<\/p>\n The finding, which was presented on 8 June at the annual meeting of the American Society for Microbiology (ASM) in Atlanta, Georgia, comes amid a growing interest in how an animal\u2019s microbiome\u00a0influences its ability to adapt to environmental change<\/a>. Researchers studying koalas and other vulnerable species are trying to find out whether\u00a0altering an animal\u2019s gut bacteria through changes in diet<\/a>\u2014 or even faecal transplants \u2014 can increase its chance of survival.<\/p>\n That is an urgent question for the koala (Phascolarctos cinereus<\/i>), whose habitat in Australia is under threat from human activity. In some places, the koala population dwarfs the supply of eucalyptus \u2014 but even when the animals are transplanted to areas with abundant food, some die. Experiments by koala ecologist Ben Moore and his colleagues at Western Sydney University in Australia suggest that this might be due to an incompatibility between available eucalyptus varieties and the composition of an individual koala\u2019s gut bacteria.<\/p>\n Moore and his colleagues collected faeces from 200 koalas at 20 sites around Australia. When the researchers analysed the plant materials in the faeces, they found that some koalas ate only a highly nutritious eucalyptus species known as manna gum (Eucalyptus viminalis<\/i>). Others ate less-nutritious messmate (E. obliqua<\/i>), and only a fraction of the animals would eat both \u2014 even at the same site. Two animals living 10 metres apart might have different food preferences.<\/p>\n When Moore and his colleagues analysed the microbial make-up of the faeces, they found that the koalas that preferred manna-gum eucalyptus harboured different bacteria from those that ate messmate. To test whether the different diets were the cause or the result of the different microbiomes, the researchers transplanted faeces from six wild koalas that ate messmate into six wild koalas that preferred manna gum. Within 18 days, the microbiomes of the koalas that underwent the procedure were nearly identical to those of the donor animals. Some of the animals that received transplants also seemed more willing to eat messmate.<\/p>\n To Moore, this suggests that koala-to-koala faecal transplants might help to expand the types of food available to individual animals and increase their chances of survival.<\/p>\n Eria Rebollar, a microbial ecologist at the National Autonomous University in Mexico City, says that the koala study is one of the first demonstrations that fecal transplants can affect the composition of wild animals’ microbiomes. Her own research, presented at the ASM meeting, has found that transplanting bacteria found on some frogs’ skin to other frogs can protect the recipients from\u00a0deadly fungal infections<\/a>.<\/p>\n <\/p>\n Interspecies transplant<\/b><\/p>\n Other experiments suggest that some animals could benefit from having their microbiomes reshaped by faecal transplants from another species. A team led by Denise Dearing, a molecular biologist at the University of Utah in Salt Lake City, has found that desert woodrats (Neotoma lepida<\/i>) \u2014 distant relatives of laboratory rats \u2014 carry gut bacteria that allow them to eat plants containing oxalate, a chemical that causes kidney stones. When the scientists, who work with Moore\u2019s group, transplanted woodrat faeces into lab rats, the lab rats gained the ability to degrade oxalate1<\/a><\/sup>.<\/p>\n Other research suggests that protecting some endangered species might be as simple as changing their diet to accommodate the microbiome that is already there. At the ASM meeting, scientists from the San Diego Zoo in California presented findings that suggest how the gut microbiome of the near-threatened southern white rhinoceros (Ceratotherium simum simum<\/i>) could interfere with its fertility. Captive-born southern white rhinos do not reproduce well.<\/p>\n The team from the San Diego Zoo compared the faeces of captive white rhinos with those of one-horned rhinos (Rhinoceros unicornis<\/i>), which reproduce well in captivity. The white-rhino faeces contained chemicals known as phytoestrogens, which are present in plants such as soya and alfalfa and affect female reproductive hormones. Because both species of rhino ate the same diet, the researchers suspected2<\/a><\/sup>\u00a0that their gut microbes might break phytoestrogens down differently.<\/p>\n To test this, the zoo workers switched the female white rhinoceroses\u2019 diet to grass pellets, which are low in phytoestrogens. Within two years, two females that had never successfully reproduced became pregnant; they went on to give birth to healthy calves. Candace Williams, a molecular biologist at the San Diego Zoo, says that the facility is now feeding grass pellets to all its rhinos \u2014 and researchers there are discussing their success with colleagues at other zoos.<\/p>\n Williams and her colleagues are now trying to identify which bacteria might be responsible for the shift, and comparing the microbiota of captive rhinos to those of wild rhinos in South Africa. \u201cIn zoo settings, people don’t think too much about microbes that live in these amazing animals,\u201d Williams says.<\/p>\n That could change as DNA-sequencing technology continues to advance, and allows researchers to discover the composition of an animal\u2019s microbiome more easily, Dearing says. She predicts that such tests will reveal many more instances of animals\u2019 microbiota affecting their ability to survive in the wild. \u201cI think it\u2019s more common than we’ve been able to document,\u201d she says. \u201cIn part we just didn\u2019t have the tools to do this until recently.\u201d<\/p>\n <\/p>\n<\/div>\n