{"id":4977,"date":"2020-02-24T19:57:11","date_gmt":"2020-02-24T10:57:11","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=4977"},"modified":"2020-02-24T19:57:11","modified_gmt":"2020-02-24T10:57:11","slug":"%ec%83%9d%eb%ac%bc%ea%b3%bc-%eb%ac%b4%ec%83%9d%eb%ac%bc-%ea%b0%84%ea%b2%a9-%eb%a9%94%ec%9a%b0%eb%8a%94-%eb%b0%94%ec%9d%b4%eb%9f%ac%ec%8a%a4-%eb%b0%9c%ea%b2%ac","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4977","title":{"rendered":"\uc0dd\ubb3c\uacfc \ubb34\uc0dd\ubb3c \uac04\uaca9 \uba54\uc6b0\ub294 \ubc14\uc774\ub7ec\uc2a4 \ubc1c\uacac"},"content":{"rendered":"

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73\ub9cc\uc5ec \uc5fc\uae30\uc30d\uc5d0 \ubc15\ud14c\ub9ac\uc544 \uc720\uc804\uc790\ub85c \ub2e4\ub978 \ubc14\uc774\ub7ec\uc2a4 \ubc29\ud574<\/b><\/p>\n

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\uc0dd\ubb3c \uc138\ud3ec\ub294 \uc2a4\uc2a4\ub85c \ubcf5\uc81c\ub418\ub294\ub370 \ube44\ud574 \ubc14\uc774\ub7ec\uc2a4\ub294 \uc2a4\uc2a4\ub85c \ubcf5\uc81c\ub418\uc9c0 \ubabb\ud558\uace0 \ubc15\ud14c\ub9ac\uc544 \uac19\uc740 \uc219\uc8fc \uc18d\uc5d0 \ub4e4\uc5b4\uac04 \ub4a4 \uc219\uc8fc\uc758 \ubcf5\uc81c \uc2dc\uc2a4\ud15c\uc744 \uc774\uc6a9\ud574 \uc790\uc2e0\uc758 \uc720\uc804\uccb4\ub97c \ubcf5\uc81c\ud574 \uc99d\uc2dd\ud55c\ub2e4.<\/p>\n

\uc219\uc8fc\uc5d0 \ub4e4\uc5b4\uac00\uc9c0 \ubabb\ud558\uba74 \ub2e8\ubc31\uc9c8 \ub369\uc5b4\ub9ac\uc778 \ubb34\uc0dd\ubb3c \uc0c1\ud0dc\ub85c \uc874\uc7ac\ud558\uae30 \ub54c\ubb38\uc5d0 \ubc14\uc774\ub7ec\uc2a4\ub294 \uc0dd\ubb3c\uacfc \ubb34\uc0dd\ubb3c\uc758 \ud2b9\uc131\uc744 \ubaa8\ub450 \uac16\uace0 \uc788\ub294 \uc148\uc774\ub2e4.<\/p>\n

\ubbf8\uad6d \uacfc\ud559\uc790\ub4e4\uacfc \uad6d\uc81c \ud611\ub3d9\uc5f0\uad6c\uc9c4\uc740 \ucd5c\uadfc \uc0b4\uc544\uc788\ub294 \uc720\uae30\uccb4\uc640 \uad00\ub828\ub41c \ub2a5\ub825\uc744 \uc9c0\ub2d8\uc73c\ub85c\uc368 \uc0b4\uc544 \uc788\ub294 \ubbf8\uc0dd\ubb3c\uacfc \ubc14\uc774\ub7ec\uc2a4\uccb4 \uc0ac\uc774\uc758 \uacbd\uacc4\ub97c \ubaa8\ud638\ud558\uac8c \ud558\ub294 \uc218\ubc31 \uc885\uc758 \ucee4\ub2e4\ub780 \ubc15\ud14c\ub9ac\uc544\ub97c \ubc1c\uacac\ud588\ub2e4.<\/p>\n

\ubc15\ud14c\ub9ac\uc544 \uc18d\uc73c\ub85c \uce68\ud22c\ud574 \uc774\ub97c \u2018\uba39\uc774\u2019\ub85c \uc0bc\uae30 \ub54c\ubb38\uc5d0 \ubc15\ud14c\ub9ac\uc624\ud30c\uc9c0(bacteriophages)\ub85c \ubd88\ub9ac\ub294 \uc774 \ud30c\uc9c0(phages)\ub4e4\uc740 \uc0dd\uba85\uc758 \uc804\ud615\uc73c\ub85c \uac04\uc8fc\ub418\ub294 \ud06c\uae30\uc640 \ubcf5\uc7a1\uc131\uc744 \uac16\ucd94\uace0 \uc788\ub294 \ub370\ub2e4 \ud1b5\uc0c1 \ubc15\ud14c\ub9ac\uc544\uc5d0\uc11c \ubc1c\uacac\ub418\ub294 \uc218\ub9ce\uc740 \uc720\uc804\uc790\ub97c \uc9c0\ub2c8\uace0 \uc788\uace0, \uc219\uc8fc\uc778 \ubc15\ud14c\ub9ac\uc544\ub97c \ub300\uc0c1\uc73c\ub85c \uc774 \uc720\uc804\uc790\ub4e4\uc744 \ud65c\uc6a9\ud558\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4.<\/p>\n

\uc774 \uc5f0\uad6c\ub294 \uacfc\ud559\uc800\ub110 \u2018\ub124\uc774\ucc98\u2019(Nature) 12\uc77c \uc790\uc5d0 \ubc1c\ud45c\ub410\ub2e4.<\/p>\n

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\ubc15\ud14c\ub9ac\uc544 \uc138\ud3ec\ub97c \uac10\uc5fc\uc2dc\ud0a4\ub294 \uac70\ub300 \ud30c\uc9c0(\uc67c\ucabd \ube68\uac04\uc0c9)\uc640 \uc77c\ubc18\uc801\uc778 \ud30c\uc9c0\uac00 \ubc15\ud14c\ub9ac\uc544\uc5d0 \uce68\ud22c\ud558\ub294 \uadf8\ub9bc. \uac70\ub300 \ud30c\uc9c0\uac00 \uc219\uc8fc \uc138\ud3ec\uc5d0 DNA\ub97c \uc8fc\uc785\ud558\uace0 \uc788\uace0, \uc77c\ubc18\uc801\uc73c\ub85c \ubc15\ud14c\ub9ac\uc544\uc640 \uace0\uc138\uade0\uc5d0\uc11c\ub9cc \ubc1c\uacac\ub418\ub294 CRISPR \uba74\uc5ed\uc2dc\uc2a4\ud15c\uc744 \uac00\uc9c4 \uc774 \uac70\ub300 \ud30c\uc9c0\uac00 \ub2e4\ub978 \ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud55c \uc219\uc8fc \uc138\ud3ec\uc758 \ubc18\uc751\uc744 \uc870\uc791\ud55c\ub2e4. \u24d2 UC Berkeley image courtesy of Jill Banfield lab<\/span><\/span> <\/p>\n

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\uc9c0\uad6c 30\uac1c \ud658\uacbd\uc5d0\uc11c \ub300\uaddc\ubaa8 DNA \ub370\uc774\ud130\ubca0\uc774\uc2a4 \uc0dd\uc131<\/strong><\/p>\n

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\n\uc5f0\uad6c\ub97c \uc218\ud589\ud55c \ubbf8\uad6d \uce98\ub9ac\ud3ec\ub2c8\uc544\ub300(\ubc84\ud074\ub9ac) \uc5f0\uad6c\ud300\uacfc \ud611\ub3d9\uc5f0\uad6c\uc790\ub4e4\uc740 \uc870\uc219\uc544\uc640 \uc784\uc2e0\ubd80\uc758 \uc7a5\uc5d0\uc11c\ubd80\ud130 \ud2f0\ubca0\ud2b8\uc758 \uc628\ucc9c, \ub0a8\uc544\ud504\ub9ac\uce74\uc758 \uc0dd\ubb3c\ubc18\uc751\uae30, \ubcd1\uc6d0 \uc785\uc6d0\uc2e4, \ubc14\ub2e4, \ud638\uc218 \ubc0f \uc9c0\ud558 \uae4a\uc740 \uacf3\uae4c\uc9c0\ub97c \ud3ec\ud568\ud55c \uc57d 30\uac1c\uc758 \uc11c\ub85c \ub2e4\ub978 \uc9c0\uad6c \ud658\uacbd\uc73c\ub85c\ubd80\ud130 \ub300\uaddc\ubaa8 DNA \ub370\uc774\ud130\ubca0\uc774\uc2a4\ub97c \uc0dd\uc131\ud574 \uc774 \uac70\ub300 \ud30c\uc9c0\ub4e4\uc744 \ucc3e\uc544\ub0c8\ub2e4.<\/p>\n

\uc5f0\uad6c\ud300\uc774 \ubc1c\uacac\ud55c \uac83\uc740 \ubaa8\ub450 351\uac1c\uc758 \uc11c\ub85c \ub2e4\ub978 \uac70\ub300 \ud30c\uc9c0\ub4e4\ub85c, \ub2e8\uc138\ud3ec \ubc15\ud14c\ub9ac\uc544\uc5d0 \uce68\ud22c\ud558\ub294 \uc77c\ubc18 \ubc14\uc774\ub7ec\uc2a4\ub4e4\uc758 \ud3c9\uade0 \uac8c\ub188\ubcf4\ub2e4 \ub124 \ubc30 \uc774\uc0c1 \ud070 \uc720\uc804\uccb4\ub97c \uc9c0\ub154\ub2e4.<\/p>\n

\uc9c0\uae08\uae4c\uc9c0 \ubc1c\uacac\ub41c \ud30c\uc9c0 \uac00\uc6b4\ub370 \uac00\uc7a5 \ud070 \uac83\uc740 \ud3c9\uade0\uc801\uc778 \ud30c\uc9c0\ubcf4\ub2e4 \uac70\uc758 15\ubc30 \uc774\uc0c1 \uae34 73\ub9cc 5000\uac1c\uc758 \uc5fc\uae30\uc30d\uc744 \uac00\uc9c0\uace0 \uc788\uc5c8\ub2e4. \uc774 \ud30c\uc9c0\uc758 \uc720\uc804\uccb4\ub294 \ub9ce\uc740 \ubc15\ud14c\ub9ac\uc544\uc758 \uc720\uc804\uccb4\ubcf4\ub2e4 \ud6e8\uc52c \ucef8\ub2e4.<\/p>\n

\ub17c\ubb38 \uc2dc\ub2c8\uc5b4 \uc800\uc790\uc778 \uce98\ub9ac\ud3ec\ub2c8\uc544(\ubc84\ud074\ub9ac)\ub300 \uc9c8 \ubc34\ud544\ub4dc(Jill Banfield) \uad50\uc218(\uc9c0\uad6c \ubc0f \ud589\uc131\uacfc\ud559, \ud658\uacbd\uacfc\ud559)\ub294 \u201c\uc9c0\uad6c\uc758 \ubbf8\uc0dd\ubb3c \uad70\uc9d1\uc744 \uc870\uc0ac\ud558\uba70 \uac00\ub054 \uc608\uae30\uce58 \uc54a\uc740 \uc77c\uc744 \ub9cc\ub098\uae30\ub3c4 \ud55c\ub2e4\u201d\uba70, \u201c\uc774 \ubc15\ud14c\ub9ac\uc624\ud30c\uc9c0\ub4e4\uc740 \ubab8\uccb4\ub97c \ubcf5\uc81c\ud558\ub294 \uc0dd\ubb3c\ud559 \uc5f0\uad6c\uc758 \ud55c \ub300\uc0c1\uc774\uc9c0\ub9cc \ud604\uc7ac\ub294 \uadf8\uc5d0 \uad00\ud574 \uc544\ub294 \uac83\uc774 \uac70\uc758 \uc5c6\ub2e4\u201d\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\uadf8\ub294 \u201c\uc774\ub7f0 \ub300\ud615 \ud30c\uc9c0\ub4e4\uc740 \ubb34\uc0dd\ubb3c\uacfc \ubc15\ud14c\ub9ac\uc624\ud30c\uc9c0 \uac04\uc758 \uac04\uaca9\uacfc \ud568\uaed8 \ubc15\ud14c\ub9ac\uc544\uc640 \uace0\uc138\uade0\ub958(Archaea) \uc0ac\uc774\uc758 \uac04\uaca9\uc744 \uba54\uc6cc\uc900\ub2e4\u201d\uace0 \uc124\uba85\ud558\uace0, \u201c\uc6b0\ub9ac\uac00 \uc804\ud1b5\uc801\uc73c\ub85c \ubc14\uc774\ub7ec\uc2a4\uc640 \uc0dd\ubb3c\uc774\ub77c\uace0 \uc0dd\uac01\ud558\ub294 \uac83 \uc0ac\uc774\uc5d0 \ud63c\uc885\uc774 \uc874\uc7ac\ud558\ub294 \uac83\uc740 \ubd84\uba85\ud788 \uc131\uacf5\uc801\uc778 \uc0dd\uc874 \uc804\ub7b5\uc73c\ub85c \ubcf4\uc778\ub2e4\u201d\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

\uc5ed\uc124\uc801\uc774\uac8c\ub3c4, \uc774 \uac70\ub300 \ud30c\uc9c0\ub4e4\uc774 \uc6b4\ubc18\ud558\ub294 DNA \uc548\uc5d0\ub294 \ubc15\ud14c\ub9ac\uc544\uac00 \ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud56d\ud574 \uc2f8\uc6b8 \ub54c \uc0ac\uc6a9\ud558\ub294 \ud06c\ub9ac\uc2a4\ud37c(CRISPR) \uc2dc\uc2a4\ud15c \uc77c\ubd80\uac00 \ub4e4\uc5b4\uc788\uc5c8\ub2e4.<\/p>\n

\uc77c\ub2e8 \ud30c\uc9c0\ub4e4\uc774 \uc790\uc2e0\ub4e4\uc758 DNA\ub97c \ubc15\ud14c\ub9ac\uc544\uc5d0 \uc8fc\uc785\ud558\uba74 \ud30c\uc9c0\uc758 \ubc14\uc774\ub7ec\uc2a4\uc131 \ud06c\ub9ac\uc2a4\ud37c \uc2dc\uc2a4\ud15c\uc740 \uc219\uc8fc\uc778 \ubc15\ud14c\ub9ac\uc544\uc758 \ud06c\ub9ac\uc2a4\ud37c \uc2dc\uc2a4\ud15c\uc744 \uc99d\uac15\uc2dc\ud0a4\ub294\ub370, \uc774\ub294 \ub2e4\ub978 \ubc14\uc774\ub7ec\uc2a4\ub4e4\uc758 \uce68\uc785\uc744 \ub9c9\ub294\ub370 \uc4f0\uc774\ub294 \uac83\uc73c\ub85c \ubcf4\uace0 \uc788\ub2e4.<\/p>\n

\ub17c\ubb38 \uacf5\ub3d9 \uc81c1\uc800\uc790\uc778 UC\ubc84\ud074\ub9ac\ub300 \ub300\ud559\uc6d0\uc0dd \uc54c-\uc0e4\uc5d0\ube0c(Al-Shayeb) \uc5f0\uad6c\uc6d0\uc740 \u201c\ubc15\ud14c\ub9ac\uc544\uc544\ub098 \uace0\uc138\uade0\uc774 \uacbd\uc7c1\uc790\ub4e4\uc5d0 \ub300\ud56d\ud574 \uc790\uc2e0\uc758 \uc774\uc775\uc744 \uc9c0\ud0a4\uae30 \uc704\ud574 \uc0ac\uc6a9\ud588\ub358 \uc2dc\uc2a4\ud15c\uc744 \uc774 \ud30c\uc9c0\ub4e4\uc774 \uc5b4\ub5bb\uac8c \uc6a9\ub3c4\ub97c \ubc14\uafd4 \ubc14\uc774\ub7ec\uc2a4\ub4e4 \uac04\uc758 \uc804\ud22c\uc5d0 \ud65c\uc6a9\ud558\uac8c \ub418\uc5c8\ub294\uac00\ub294 \ub9e4\uc6b0 \ud765\ubbf8\ub85c\uc6b4 \uc77c\u201d\uc774\ub77c\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

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\uacfc\ud559\uc800\ub110 \u2018\ub124\uc774\ucc98\u2019 12\uc77c \uc790\uc5d0 \uc2e4\ub9b0 \ub17c\ubb38 \ud45c\uc9c0. \u24d2 SPRINGER NATURE<\/span><\/span> <\/p>\n

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\uc0c8\ub85c\uc6b4 \uce74\uc2a4(Cas) \ub2e8\ubc31\uc9c8<\/strong><\/p>\n

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\n\uac70\ub300 \ud30c\uc9c0 \uc911 \ud558\ub098\ub294 \ub610\ud55c UC\ubc84\ud074\ub9ac\ub300 \uc81c\ub2c8\ud37c \ub2e4\uc6b0\ub4dc\ub098(Jennifer Doudna) \uad50\uc218\uc640 \ub3c5\uc77c \ud558\ub178\ubc84\ub300 \uc5e0\ub9c8\ub204\uc5d8\ub808 \uc0e4\ub974\ud310\ud2f0\uc5d0(Emmanuelle Charpentier) \uad50\uc218\uac00 \uc720\uc804\uc790 \ud3b8\uc9d1\uc744 \uc704\ud574 \ucc44\ud0dd\ud55c \ud601\uba85\uc801 \ub3c4\uad6c\uc778 \ud06c\ub9ac\uc2a4\ud37c\/\uce74\uc2a49(CRISPR-Cas9)\uc758 \uce74\uc2a49 \ub2e8\ubc31\uc9c8\uacfc \uc720\uc0ac\ud55c \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4e4 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ud655\uc778\ub410\ub2e4.<\/p>\n

\uc5f0\uad6c\ud300\uc740 \uadf8\ub9ac\uc2a4 \ubb38\uc790 \ud30c\uc774(\u00d8, phi)\uac00 \uc804\ud1b5\uc801\uc73c\ub85c \ubc15\ud14c\ub9ac\uc624\ud30c\uc9c0\ub97c \ub098\ud0c0\ub0b4\ub294\ub370 \uc0ac\uc6a9\ub418\uc5c8\uae30 \ub54c\ubb38\uc5d0 \uc774 \uc791\uc740 \ub2e8\ubc31\uc9c8\uc5d0 \uce74\uc2a4 \ud30c\uc774(Cas\u00d8)\ub77c\ub294 \uc774\ub984\uc744 \ubd99\uc600\ub2e4.<\/p>\n

\ub17c\ubb38 \uacf5\ub3d9 \uc81c1\uc800\uc790\uc778 \ub85c\ud55c \uc0ac\ud06c\ub370\ubc14(Rohan Sachdeva) \uc5f0\uad6c\uc6d0\uc740 \u201c\uc774 \uac70\ub300 \ud30c\uc9c0\uc5d0\ub294 \uac8c\ub188 \uacf5\ud559\uc5d0 \ud544\uc694\ud55c \uc0c8\ub85c\uc6b4 \ub3c4\uad6c\ub97c \ucc3e\uc744 \uc218 \uc788\ub294 \uac00\ub2a5\uc131\uc774 \ub9ce\ub2e4\u201d\uba70, \u201c\uc6b0\ub9ac\uac00 \uc774\ubc88\uc5d0 \ubc1c\uacac\ud55c \ub9ce\uc740 \uc720\uc804\uc790\ub4e4\uc740 \uc54c\ub824\uc9c0\uc9c0 \uc54a\uc740 \uac83\uc73c\ub85c \uc5b4\ub5a4 \uae30\ub2a5\uc744 \ud558\ub294\uc9c0 \uc81c\ub300\ub85c \ucd94\uc815\ud560 \uc218 \uc5c6\uc73c\ub098, \uc0b0\uc5c5\uacfc \uc758\ub8cc, \ub18d\uc5c5 \ubd84\uc57c\uc5d0 \ud65c\uc6a9\ud560 \uc218 \uc788\ub294 \uc0c8\ub85c\uc6b4 \ub2e8\ubc31\uc9c8 \uacf5\uae09\uc6d0\uc774 \ub420 \uc218 \uc788\ub2e4\u201d\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\uc774\ubc88 \ubc1c\uacac\uc740 \ud30c\uc9c0\uc640 \ubc15\ud14c\ub9ac\uc544 \uac04\uc758 \uc9c0\uc18d\uc801\uc778 \uc804\uc7c1\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \ud1b5\ucc30\uc744 \uc81c\uacf5\ud558\ub294 \uc678\uc5d0 \uc778\uccb4 \uc9c8\ubcd1 \uad00\ub828 \ubb38\uc81c\uc5d0\ub3c4 \uc601\ud5a5\uc744 \ubbf8\uce5c\ub2e4.<\/p>\n

\ubc14\uc774\ub7ec\uc2a4\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \ud56d\uc0dd\uc81c\uc5d0 \ub0b4\uc131\uc744 \ubd80\uc5ec\ud558\ub294 \uc720\uc804\uc790\ub97c \ud3ec\ud568\ud574 \uc138\ud3ec \uc0ac\uc774\uc5d0\uc11c \uc5ec\ub7ec \uc720\uc804\uc790\ub97c \uc6b4\ubc18\ud55c\ub2e4. \ud30c\uc9c0\ub4e4\uc740 \uc778\uccb4 \uc7a5\ub0b4 \ubbf8\uc0dd\ubb3c\uad70\uc744 \ube44\ub86f\ud574 \ubc15\ud14c\ub9ac\uc544\uc640 \uace0\uc138\uade0\uc774 \uc0ac\ub294 \uacf3\uc774\uba74 \uc5b4\ub514\uc5d0\uc11c\ub4e0 \ubc1c\uc0dd\ud558\uae30 \ub54c\ubb38\uc5d0, \uc778\uccb4\uc5d0 \uc11c\uc2dd\ud558\ub294 \ubc15\ud14c\ub9ac\uc544\uc5d0\ub3c4 \uc720\ud574\ud55c \uc720\uc804\uc790\ub4e4\uc744 \uc62e\uae38 \uc218 \uc788\ub2e4.<\/p>\n

\ubc34\ud544\ub4dc \uad50\uc218\ub294 \u201c\ud30c\uc9c0\ub4e4\uc774 \ubcd1\uc744 \uc77c\uc73c\ud0a4\uac70\ub098 \ud56d\uc0dd\uc81c \ub0b4\uc131\uc744 \ubd80\uc5ec\ud558\ub294 \uc720\uc804\uc790\ub4e4 \uc8fc\ubcc0\uc744 \ub3cc\uc544\ub2e4\ub2c8\uae30 \ub54c\ubb38\uc5d0 \uc77c\ubd80 \uc9c8\ubcd1\ub4e4\uc740 \uac04\uc811\uc801\uc73c\ub85c \ud30c\uc9c0\uc5d0 \uc758\ud574 \ubc1c\uc0dd\ud55c\ub2e4\u201d\uace0 \uc9c0\uc801\ud558\uace0, \u201c\uac8c\ub188\uc774 \ud074\uc218\ub85d \uadf8\ub7f0 \uc720\uc804\uc790 \uc8fc\uc704\ub97c \uc6c0\uc9c1\uc77c \uc218 \uc788\ub294 \ub2a5\ub825\uc774 \ucee4\uc9c0\uace0, \uc778\uccb4 \uc7a5\ub0b4 \ubbf8\uc0dd\ubb3c\uad70\uc5d0 \ubc14\ub78c\uc9c1\ud558\uc9c0 \uc54a\uc740 \uc720\uc804\uc790\ub97c \uc804\ub2ec\ud560 \ud655\ub960\uc774 \ub192\uc544\uc9c8 \uc218 \uc788\ub2e4\u201d\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

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\uc9c0\uad6c\uc758 \uc0dd\ubb3c\uad70\uacc4(biomes)\ub97c \uc2dc\ud000\uc2f1<\/strong><\/p>\n

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\n\ubc34\ud544\ub4dc \uad50\uc218\ub294 15\ub144 \uc774\uc0c1 \ubc15\ud14c\ub9ac\uc544\uc640 \u2018\ubc15\ud14c\ub9ac\uc544\uc758 \ub9e4\ub825\uc801\uc778 \uc0ac\ucd0c\uc778\u2019 \uace0\uc138\uade0 \uadf8\ub9ac\uace0 \uc9c0\uad6c\uc758 \ub2e4\uc591\ud55c \ud658\uacbd\uc5d0 \uc874\uc7ac\ud558\ub294 \ud30c\uc9c0\uc758 \ub2e4\uc591\uc131\uc744 \ud0d0\uad6c\ud574 \uc654\ub2e4.<\/p>\n

\uadf8\ub294 \ud45c\ubcf8\uc5d0 \uc788\ub294 \ubaa8\ub4e0 DNA\ub97c \uc2dc\ud000\uc2f1\ud55c \ub2e4\uc74c \uc870\uac01\ub4e4\uc740 \ubaa8\uc544 \ub2e4\uc2dc \uac8c\ub188 \ucd08\uc548\uc744 \uc870\ub9bd\ud558\uace0, \uacbd\uc6b0\uc5d0 \ub530\ub77c\uc11c\ub294 \uc9c0\uae08\uae4c\uc9c0 \ubcf8 \uc801\uc774 \uc5c6\ub294 \ubbf8\uc0dd\ubb3c\uc758 \uac8c\ub188\uc744 \uc644\uc804\ud788 \uc0c8\ub85c \uc870\ub9bd\ud55c\ub2e4.<\/p>\n

\uadf8 \uacfc\uc815\uc5d0\uc11c \uadf8\ub294 \ub9ce\uc740 \uc0c8\ub85c\uc6b4 \ubbf8\uc0dd\ubb3c\ub4e4\uc774 \uc544\uc8fc \uc791\uc740 \uac8c\ub188\uc744 \uac00\uc9c0\uace0 \uc788\uc5b4 \ub3c5\ub9bd\uc801\uc778 \uc0dd\uba85\uc744 \uc720\uc9c0\ud558\uae30\uc5d0\ub294 \ubd88\ucda9\ubd84\ud55c \uac83\uc73c\ub85c \ubcf4\uc778\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1c\uacac\ud588\ub2e4. \ub300\uc2e0 \uadf8\ub4e4\uc740 \uc0b4\uc544\ub0a8\uae30 \uc704\ud574 \ubc15\ud14c\ub9ac\uc544\uc640 \uace0\uc138\uade0\uc5d0 \uc758\uc874\ud558\ub294 \uac83\uc73c\ub85c \ubcf4\uc600\ub2e4.<\/p>\n

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 <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\"\"<\/a><\/p>\n
\n
\ud30c\uc9c0\uc758 \ud130\ubbf8\ub098\uc544\uc81c \uc720\uc804\uc790 \uc11c\uc5f4\uc744 \uc774\uc6a9\ud574 \uc7ac\uad6c\uc131\ud55c \uac70\ub300 \ud30c\uc9c0\uc758 \uacc4\ud1b5\ub3c4. \ub0b4\ubd80 \ub9c1\uacfc \uc678\ubd80 \ub9c1\uc740 CRISPR-Cas \uc2dc\uc2a4\ud15c\uc758 \uc874\uc7ac\uc640 \ud638\uc2a4\ud2b8 \ubb38(phylum), \ud658\uacbd \uc0d8\ud50c\ub9c1 \uc720\ud615\uacfc \uac8c\ub188 \ud06c\uae30\ub97c \ub098\ud0c0\ub0b8\ub2e4. \uc0c8\ub85c \ud655\uc778\ub41c 10\uac1c\uc758 \uac70\ub300 \ud30c\uc9c0 \uadf8\ub8f9\uc740 \uc67c\ucabd\uc5d0 \ud45c\uc2dc\ud588\ub2e4. \u24d2 Jill Banfield Lab<\/span><\/span> <\/p>\n

 <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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1\ub144 \uc804 \ubc34\ud544\ub4dc \uad50\uc218\ub294 \uc790\uc2e0\uc774 \ub77d \ud30c\uc9c0(Lak phages)\ub77c\uace0 \uc774\ub984 \ubd99\uc778 \uac00\uc7a5 \ud070 \ud30c\uc9c0 \uac00\uc6b4\ub370 \uc77c\ubd80\uac00 \uc778\uccb4\uc758 \uc7a5\uacfc \uc785\uc5d0\uc11c \ubc1c\uacac\ub420 \uc218 \uc788\ub2e4\uace0 \ubcf4\uace0\ud588\ub2e4. \uc774 \ud30c\uc9c0\ub4e4\uc740 \uc7a5\uacfc \uce68\uc758 \ubbf8\uc0dd\ubb3c\uc744 \uba39\uc774\ub85c \uc0bc\ub294\ub2e4.<\/p>\n

\uc774\ubc88\uc758 \uc0c8\ub85c\uc6b4 \u2018\ub124\uc774\ucc98\u2019 \ub17c\ubb38\uc740 \ubc34\ud544\ub4dc \uad50\uc218\uac00 \ucd95\uc801\ud574 \uc628 \ubaa8\ub4e0 \uade0\uc720\uc804\uccb4\ud559 \uc11c\uc5f4 \uc548\uc5d0\uc11c \uac70\ub300 \ud30c\uc9c0\ub4e4\uc744 \ub354\uc6b1 \ucca0\uc800\ud558\uac8c \uac80\uc0c9\ud574 \ub098\uc628 \uacb0\uacfc\ubb3c\ub85c, \uc804 \uc138\uacc4 \ud611\ub825\uc5f0\uad6c\uc790\ub4e4\uc774 \uc81c\uacf5\ud55c \uc0c8\ub85c\uc6b4 \uba54\ud0c0\uac8c\ub188(metagenomes)\ub4e4\uc744 \ucd94\uac00\ud588\ub2e4. \uba54\ud0c0\uac8c\ub188\uc774\ub780 \uc5b4\ub5a4 \ud658\uacbd \uc548\uc5d0\uc11c \uc874\uc7ac\ud558\ub294 \ubbf8\uc0dd\ubb3c\ub4e4\uc758 \ucd1d\uccb4\uc801\uc778 \uac8c\ub188\uc744 \ub9d0\ud55c\ub2e4.<\/p>\n

\uc774\ubc88\uc758 \uba54\ud0c0\uac8c\ub188\uc740 \uac1c\ucf54\uc6d0\uc22d\uc774\uc640 \ub3fc\uc9c0, \uc54c\ub798\uc2a4\uce74 \ubb34\uc2a4, \ud1a0\uc591 \ud45c\ubcf8, \ubc14\ub2e4, \uac15, \ud638\uc218, \uc9c0\ud558\uc218\uc5d0\uc11c \ud655\ubcf4\ud588\uace0, \ube44\uc18c\ub85c \uc624\uc5fc\ub41c \ubb3c\uc744 \ub9c8\uc2dc\uace0 \uc788\uc5c8\ub358 \ubc29\uae00\ub77c\ub370\uc2dc\uc778\ub4e4\ub3c4 \ud3ec\ud568\ub410\ub2e4.<\/p>\n

\uc5f0\uad6c\ud300\uc740 \uae38\uc774 200 \ud0ac\ub85c\ubca0\uc774\uc2a4(kilobase) \uc774\uc0c1\uc778 351\uac1c\uc758 \ud30c\uc9c0 \uac8c\ub188\uc744 \ud655\uc778\ud588\uc73c\uba70, \uc774 \uac8c\ub188\ub4e4\uc740 \ud30c\uc9c0 \ud3c9\uade0 \uac8c\ub188 \uae38\uc774(50\ud0ac\ub85c\ubca0\uc774\uc2a4)\uc758 \ub124 \ubc30\ub098 \ub418\uc5c8\ub2e4. 175\uac1c \ud30c\uc9c0\uc758 \uac8c\ub188\uc740 \uae38\uc774\ub97c \uc815\ud655\ud558\uac8c \ud655\uc778\ud560 \uc218 \uc788\uc5c8\uace0, \ub098\uba38\uc9c0\ub294 200\ud0ac\ub85c\ubca0\uc774\uc2a4 \uc774\uc0c1 \ub418\ub294 \uac83\uc73c\ub85c \uc5ec\uaca8\uc84c\ub2e4.<\/p>\n

\uc644\uc804\ud55c \uac8c\ub188 \ud558\ub098\ub294 73\ub9cc 5000 \uc5fc\uae30\uc30d\uc73c\ub85c, \uc9c0\uae08\uae4c\uc9c0 \uc54c\ub824\uc9c4 \ud30c\uc9c0\uc758 \uac8c\ub188 \uc911 \uac00\uc7a5 \ud070 \uac83\uc774\ub2e4.<\/p>\n

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\ud30c\uc9c0 \uc720\uc804\uc790, \ubc15\ud14c\ub9ac\uc544 \ub9ac\ubcf4\uc19c \ubc29\ud5a5 \ubc14\uafd4<\/strong><\/p>\n

 <\/p>\n

\n\uc774\ub4e4 \uac70\ub300 \ud30c\uc9c0\uc5d0 \uc788\ub294 \ub300\ubd80\ubd84\uc758 \uc720\uc804\uc790\ub294 \uc54c\ub824\uc9c0\uc9c0 \uc54a\uc740 \ub2e8\ubc31\uc9c8\uc744 \ucf54\ub529\ud588\ub2e4. \uc5f0\uad6c\ud300\uc740 \uba54\uc2e0\uc800 RNA\ub97c \ub2e8\ubc31\uc9c8\ub85c \ubc88\uc5ed\ud558\ub294 \ub9ac\ubcf4\uc19c \uae30\uad6c\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 \ub2e8\ubc31\uc9c8\uc758 \ucf54\ub529 \uc720\uc804\uc790\ub4e4\uc744 \uc2dd\ubcc4\ud574 \ub0bc \uc218 \uc788\uc5c8\ub2e4. \uc774\ub7f0 \uc720\uc804\uc790\ub4e4\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \ubc14\uc774\ub7ec\uc2a4\ub098 \ubc15\ud14c\ub9ac\uc544 \ub610\ub294 \uace0\uc138\uade0\uc5d0\uc11c\ub9cc \ubc1c\uacac\ub41c\ub2e4.<\/p>\n

\uc5f0\uad6c\ud300\uc740 \uc544\ubbf8\ub178\uc0b0\uc744 \ub9ac\ubcf4\uc19c\uc5d0 \uc804\ub2ec\ud574 \uc0c8\ub85c\uc6b4 \ub2e8\ubc31\uc9c8\ub85c \ud1b5\ud569\ud558\ub294 \ub9ce\uc740 \uc804\uc774 RNA(tRNA) \uc720\uc804\uc790\ub3c4 \ubc1c\uacac\ud588\ub2e4. tRNA\ub97c \uc6b4\ubc18\ud558\uace0 \uc870\uc808\ud558\ub294 \ub2e8\ubc31\uc9c8 \uc720\uc804\uc790\uc640, \ubc88\uc5ed\uc744 \ud65c\uc131\ud654\uc2dc\ud0a4\ub294 \ub2e8\ubc31\uc9c8 \uc720\uc804\uc790 \ub4f1\uc774 \uadf8\uac83\uc774\ub2e4.
\n\uc0ac\ud06c\ub370\ubc14 \uc5f0\uad6c\uc6d0\uc740 \u201c\uc804\ud615\uc801\uc73c\ub85c \uc0dd\ubb3c\uacfc \ubb34\uc0dd\ubb3c\uc744 \uad6c\ubd84\ud558\ub294 \uac83\uc740 \ub9ac\ubcf4\uc19c\uacfc \ub2e8\ubc31\uc9c8 \ubc88\uc5ed \ub2a5\ub825\uc744 \uac00\uc9c0\uace0 \uc788\ub290\ub0d0 \ud558\ub294 \uc810\uc73c\ub85c, \ubc14\uc774\ub7ec\uc2a4\uc640 \ubc15\ud14c\ub9ac\uc544, \uc0dd\ubb3c\uacfc \ubb34\uc0dd\ubb3c\uc744 \uad6c\ubd84\ud558\ub294 \uc8fc\uc694 \uc815\uc758 \ud2b9\uc131 \uc911 \ud558\ub098\u201d\ub77c\uace0 \uc124\uba85\ud558\uace0, \u201c\uba87\uba87 \uac70\ub300 \ud30c\uc9c0\ub294 \uc774 \ubc88\uc5ed \uae30\uad6c\ub97c \ub9ce\uc774 \uac00\uc9c0\uace0 \uc788\uc5b4\uc11c \uacbd\uacc4\ub97c \uc57d\uac04 \ud750\ub9ac\uac8c \ud55c\ub2e4\u201d\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\uac70\ub300 \ud30c\uc9c0\ub4e4\uc740 \uc774 \uc720\uc804\uc790\ub4e4\uc744 \ud65c\uc6a9\ud574 \ub9ac\ubcf4\uc19c\uc758 \ubc29\ud5a5\uc744 \ubc14\uafd4 \ubc15\ud14c\ub9ac\uc544 \ub2e8\ubc31\uc9c8\uc744 \ud76c\uc0dd\uc2dc\ud0a4\uba74\uc11c \uc790\uc2e0\uc758 \ub2e8\ubc31\uc9c8\uc744 \ub354 \ub9ce\uc774 \ubcf5\uc81c\ud558\ub294 \uac83\uc73c\ub85c \ubcf4\uace0 \uc788\ub2e4.<\/p>\n

\uc77c\ubd80 \uac70\ub300 \ud30c\uc9c0\ub4e4\uc740 \ub610\ud55c \ub300\uccb4 \uc720\uc804\uc790 \ucf54\ub4dc\uc778 \ud575\uc0b0 \ud2b8\ub9ac\ud50c\ub9bf\uc744 \uac00\uc9c0\uace0 \uc788\uc5b4 RNA\ub97c \ud574\ub3c5\ud558\ub294 \ubc15\ud14c\ub9ac\uc544 \ub9ac\ubcf4\uc19c\uc744 \ud63c\ub3d9\uc2dc\ud0b4\uc73c\ub85c\uc368 \ud2b9\uc815 \uc544\ubbf8\ub178\uc0b0\uc744 \ubd80\ud638\ud654\ud558\ub294 \uac83\uc73c\ub85c \ud655\uc778\ub410\ub2e4.<\/p>\n

\uc774\uc640 \ud568\uaed8 \uc0c8\ub85c \ubc1c\uacac\ub41c \uac70\ub300 \ud30c\uc9c0 \uc911 \uc77c\ubd80\ub294 Cas9, Cas12, CasX \ubc0f CasY \uacc4\uc5f4\uacfc \uac19\uc740 \ub2e4\uc591\ud55c \ubc15\ud14c\ub9ac\uc544 CRISPR \uc2dc\uc2a4\ud15c\uc5d0\uc11c \ubc1c\uacac\ub41c Cas \ub2e8\ubc31\uc9c8 \ubcc0\uc774\uccb4 \uc720\uc804\uc790\ub97c \ubcf4\uc720\ud558\uace0 \uc788\uc5c8\ub2e4. Cas\u00d8\ub294 Cas12 \uacc4\uc5f4\uc758 \ubcc0\uc774\uccb4\ub2e4.<\/p>\n

\uc77c\ubd80 \uac70\ub300 \ud30c\uc9c0\uc5d0\uc11c\ub294 \ubc15\ud14c\ub9ac\uc544\uac00 \ubc14\uc774\ub7ec\uc2a4 \uce68\uc785\uc5d0 \ub300\ube44\ud55c \ucc38\uace0\uc6a9 \ubc14\uc774\ub7ec\uc2a4 DNA \uc870\uac01\uc744 \uc800\uc7a5\ud558\ub294 \uac8c\ub188 \uc601\uc5ed\uc778 CRISPR \ubc30\uc5f4\uc744 \uac00\uc9c0\uace0 \uc788\ub294 \uac83\uc73c\ub85c \ud655\uc778\ub410\ub2e4. \ubc15\ud14c\ub9ac\uc544\ub294 \uc774 \ucc38\uace0\uc6a9 \uc870\uac01\uc73c\ub85c \ub2e4\uc2dc \uce68\uc785\ud55c \ud30c\uc9c0\ub97c \uc778\uc2dd\ud55c \ub4a4 Cas \ub2e8\ubc31\uc9c8\ub85c \ud30c\uc9c0\ub4e4\uc744 \uaca8\ub0e5\ud574 \uc798\ub77c\ubc84\ub9b0\ub2e4.<\/p>\n

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\u201c\ub300\ud615 \uac8c\ub188, \uc0dd\uc874 \uc704\ud55c \uc131\uacf5 \uc804\ub7b5\u201d<\/strong><\/p>\n

 <\/p>\n

\n\ubc34\ud544\ub4dc \uad50\uc218\ub294 \u201c\uc880 \ub354 \ub192\uc740 \uc218\uc900\uc5d0\uc11c \uacb0\ub860\uc744 \ub0b4\ub9ac\uc790\uba74, \ud070 \uac8c\ub188\uc744 \uac00\uc9c4 \ud30c\uc9c0\ub4e4\uc740 \ud55c \uc0dd\ud0dc\uacc4\uc5d0\uc11c\ub9cc \ud2b9\uc774\uc801\uc778 \uac83\uc774 \uc544\ub2cc, \uc804 \uc9c0\uad6c \uc0dd\ud0dc\uacc4\uc5d0\uc11c \ub9e4\uc6b0 \ub450\ub4dc\ub7ec\uc9c4 \uc874\uc7ac\u201d\ub77c\uace0 \uac15\uc870\ud558\uace0, \u201c\ud070 \uac8c\ub188\uc744 \uac00\uc9c4 \ud30c\uc9c0\ub4e4\uc740 \ud070 \uac8c\ub188\uc744 \uac16\uac8c \ub41c \uae34 \uc5ed\uc0ac\ub97c \uac00\uc9c4 \uacc4\ud1b5\uc774 \ud655\ub9bd\ub3fc \uc788\uc73c\uba70, \ub300\ud615 \uac8c\ub188\uc744 \ubcf4\uc720\ud558\ub294 \uac83\uc740 \uc0dd\uc874\uc744 \uc704\ud55c \uc131\uacf5\uc801\uc778 \uc804\ub7b5\uc73c\ub85c\uc11c \uc6b0\ub9ac\ub294 \uc774\uc5d0 \ub300\ud574 \uc798 \ubaa8\ub974\uace0 \uc788\ub2e4\u201d\uace0 \uc9c0\uc801\ud588\ub2e4.<\/p>\n

\uc5f0\uad6c\ud300\uc740 \uc774\ubc88\uc5d0 \ubc1c\uacac\ud55c 351\uac1c \uac70\ub300 \ud30c\uc9c0\ub4e4\uc744 10\uac1c\uc758 \uc0c8\ub85c\uc6b4 \uadf8\ub8f9\uc73c\ub85c \ubd84\ub958\ud558\uace0, \ub17c\ubb38 \uacf5\uc800\uc790\ub4e4\uc774 \uc0ac\uc6a9\ud558\ub294 \uc5b8\uc5b4\uc5d0\uc11c \u2018\ud06c\ub2e4(big)\u2019\ub294 \uc6a9\uc5b4\ub97c \ub530\uc640 \uac01\uac01 \uc774\ub984\uc744 \ubd99\uc600\ub2e4.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

 <\/p>\n

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(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n

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 <\/p>\n","protected":false},"excerpt":{"rendered":"

    73\ub9cc\uc5ec \uc5fc\uae30\uc30d\uc5d0 \ubc15\ud14c\ub9ac\uc544 \uc720\uc804\uc790\ub85c \ub2e4\ub978 \ubc14\uc774\ub7ec\uc2a4 \ubc29\ud574   \uc0dd\ubb3c \uc138\ud3ec\ub294 \uc2a4\uc2a4\ub85c \ubcf5\uc81c\ub418\ub294\ub370 \ube44\ud574 \ubc14\uc774\ub7ec\uc2a4\ub294 \uc2a4\uc2a4\ub85c \ubcf5\uc81c\ub418\uc9c0 \ubabb\ud558\uace0 \ubc15\ud14c\ub9ac\uc544 \uac19\uc740 \uc219\uc8fc \uc18d\uc5d0 \ub4e4\uc5b4\uac04 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\u2018\uc0dd\ubb3c \ubb34\uae30\u2019\ub85c \uc0ac\uc6a9\ud558\ub294 \ubc15\ud14c\ub9ac\uc544 \ubc1c\uacac & \ubc14\uc774\ub7ec\uc2a4 \uba39\ub294 \ubbf8\uc0dd\ubb3c \ubc1c\uacac\u2026\u201c\ud558\ub8e8 \uc218\ubc31\ub9cc\uac1c \uba39\uc5b4\uce58\uc6cc\u201d","author":"biochemistry","date":"May 7, 2019","format":false,"excerpt":"\u00a0 \u00a0 SW1 \ubc14\uc774\ub7ec\uc2a4\ub97c \uc9c0\ub2cc \uc138\uade0 \u00a0 \ubc14\uc774\ub7ec\uc2a4\ub294 \uc0dd\ubb3c\uacfc \ubb34\uc0dd\ubb3c\uc758 \uc911\uac04\uc5d0 \uc788\ub294 \uc874\uc7ac\ub2e4.\u00a0DNA\ub098\u00a0RNA\ub85c \uc720\uc804 \uc815\ubcf4\ub97c \uc800\uc7a5\ud558\uace0 \ud6c4\uc190\uc744 \ud37c\ud2b8\ub9ac\uba70 \uc9c4\ud654\ud558\ub294 \uac83\uc740 \ub2e4\ub978 \uc0dd\ubb3c\uccb4\uc640 \ub611\uac19\uc9c0\ub9cc, \ubc18\ub4dc\uc2dc \ub2e4\ub978 \uc138\ud3ec\uc758 \uc790\uc6d0\uc744 \uc774\uc6a9\ud574\uc11c \uc99d\uc2dd\ud558\ub294 \uc874\uc7ac\uc774\uace0 \uc2a4\uc2a4\ub85c\ub294 \ub300\uc0ac\ub97c \ud558\uc9c0 \uc54a\uae30 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