{"id":4965,"date":"2020-02-24T19:25:45","date_gmt":"2020-02-24T10:25:45","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=4965"},"modified":"2020-02-24T19:25:45","modified_gmt":"2020-02-24T10:25:45","slug":"how-plant-cells-sense-the-outside-world-through-hydrogen-peroxide","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4965","title":{"rendered":"How plant cells sense the outside world through hydrogen peroxide"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h5>The discovery of a sensor that detects hydrogen peroxide at the surface of a cell provides insights into the mechanisms by which plant cells perceive and respond to environmental stress.<\/h5>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div class=\"article__body serif cleared\">\n<p>Chemically reactive, oxygen-containing molecules called reactive oxygen species (ROS) are central to cell function. Plant cells generate various ROS, including hydrogen peroxide (H<sub>2<\/sub>O<sub>2<\/sub>), which has a key role in cell signalling. It is produced in an extracellular space between the plasma membrane and cell wall called the apoplast, in response to a range of factors, including stressors, plant hormones such as abscisic acid, and physical or chemical changes outside the cell<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-020-00403-y?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR1\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">1<\/a><\/sup>. But whether and how this extracellular H<sub>2<\/sub>O<sub>2<\/sub>\u00a0(eH<sub>2<\/sub>O<sub>2<\/sub>) is sensed at the cell surface is unknown.\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2032-3\" data-track=\"click\" data-label=\"https:\/\/www.nature.com\/articles\/s41586-020-2032-3\" data-track-category=\"body text link\">Writing in<i>\u00a0Nature<\/i><\/a>, Wu\u00a0<i>et al.<\/i><sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-020-00403-y?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR2\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">2<\/a><\/sup>\u00a0identify the first known cell-surface H<sub>2<\/sub>O<sub>2<\/sub>\u00a0receptor in plants.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<aside class=\"recommended pull pull--left sans-serif\" data-label=\"Related\"><a href=\"https:\/\/www.nature.com\/articles\/s41586-020-2032-3\" data-track=\"click\" data-track-label=\"recommended article\"><img decoding=\"async\" class=\"recommended__image\" src=\"https:\/\/media.nature.com\/w400\/magazine-assets\/d41586-020-00403-y\/d41586-020-00403-y_17714004.jpg\" \/><\/a><\/p>\n<p class=\"recommended__title serif\">Read the paper: Hydrogen peroxide sensor HPCA1 is an LRR receptor kinase in Arabidopsis<\/p>\n<\/aside>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>The apoplast and cell wall act as a dynamic interface between plant cells and the outside world, with all its threats, challenges and opportunities. Some eH<sub>2<\/sub>O<sub>2<\/sub>\u00a0moves from the apoplast into the cytoplasm through channel proteins called aquaporins<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-020-00403-y?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR3\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">3<\/a><\/sup>. However, unlike the cytoplasm, the apoplast contains relatively few molecules that counteract oxidation<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-020-00403-y?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR1\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">1<\/a><\/sup>\u00a0\u2014 and so ROS, including H<sub>2<\/sub>O<sub>2<\/sub>, can survive for much longer in the apoplast than in the cytoplasm. This is a compelling reason to suspect that there is a sensor for eH<sub>2<\/sub>O<sub>2<\/sub>\u00a0in the apoplast.<\/p>\n<p>Although little is known about the initial target of eH<sub>2<\/sub>O<sub>2<\/sub>, the consequences of its production are much better defined<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-020-00403-y?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR4\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">4<\/a><\/sup>. It is clear that eH<sub>2<\/sub>O<sub>2<\/sub>\u00a0triggers an influx of calcium ions (Ca<sup>2+<\/sup>) into the cell, which then leads to the systemic transmission of signals between cells in waves, activating processes such as pathogen resistance or acclimation to stress across the entire plant<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-020-00403-y?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR5\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">5<\/a><\/sup>. In addition, eH<sub>2<\/sub>O<sub>2<\/sub>\u00a0signals regulate the polarized growth of pollen tubes and root hairs<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-020-00403-y?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR6\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">6<\/a><\/sup>, and control the opening and closing of stomata<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-020-00403-y?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR3\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">3<\/a><\/sup>\u00a0\u2014 pores on the outer layer of the leaf formed by two guard cells. Stomata enable the free passage of molecules such as carbon dioxide and oxygen into the plant when open, and can close to prevent water loss from the plant.<\/p>\n<p>Wu\u00a0<i>et al.<\/i>\u00a0set out to identify cell-surface receptors for eH<sub>2<\/sub>O<sub>2<\/sub>\u00a0that trigger Ca<sup>2+<\/sup>\u00a0signalling, using a \u2018forward\u2019 genetic-screen approach. They treated seeds of the plant\u00a0<i>Arabidopsis thaliana<\/i>\u00a0with a chemical that induces DNA mutations, then screened the resulting plants to identify mutants that showed low Ca<sup>2+<\/sup>\u00a0influxes in response to H<sub>2<\/sub>O<sub>2<\/sub>. They named these mutant plants\u00a0<i>hydrogen-peroxide-induced Ca<\/i><sup><i>2+<\/i><\/sup><i>\u00a0increases 1<\/i>\u00a0(<i>hpca1<\/i>).<\/p>\n<p>The authors then identified the HPCA1 protein. They report that HPCA1 is a membrane-spanning enzyme of a protein family known as leucine-rich repeat (LRR) receptor kinases. The group also showed that HPCA1 has two special pairs of cysteine (Cys) amino-acid residues in its extracellular domain. The thiol groups of Cys residues are known<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-020-00403-y?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR7\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">7<\/a><\/sup>\u00a0to be a target for oxidation by H<sub>2<\/sub>O<sub>2<\/sub>. The authors demonstrate that the presence of eH<sub>2<\/sub>O<sub>2<\/sub>\u00a0leads to oxidation of the extracellular Cys residues of HPCA1 in guard cells. This modification activates HPCA1\u2019s intracellular kinase activity, triggering Ca<sup>2+<\/sup>-channel activation and Ca<sup>2+<\/sup>\u00a0influx, followed by stomatal closure (Fig. 1).<\/p>\n<p>&nbsp;<\/p>\n<figure class=\"figure\">\n<div class=\"embed intensity--high\">\n<div class=\"embed intensity--high\"><img decoding=\"async\" class=\"figure__image\" src=\"https:\/\/media.nature.com\/lw800\/magazine-assets\/d41586-020-00403-y\/d41586-020-00403-y_17713842.png\" alt=\"\" data-src=\"\/\/media.nature.com\/lw800\/magazine-assets\/d41586-020-00403-y\/d41586-020-00403-y_17713842.png\" \/><\/div>\n<\/div><figcaption>\n<p class=\"figure__caption sans-serif\"><span class=\"mr10\"><b>Figure 1 | The HPCA1 protein.<\/b>\u00a0Wu<i>\u00a0et al.<\/i><sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-020-00403-y?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR2\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">2<\/a><\/sup>\u00a0have identified the first extracellular sensor of hydrogen peroxide (H<sub>2<\/sub>O<sub>2<\/sub>) in plants, HPCA1. The protein has an intracellular kinase enzyme domain, and an extracellular domain that protrudes into the apoplast \u2014 the compartment between a plant cell\u2019s plasma membrane and the cell wall. HPCA1 has two special pairs of cysteine (Cys) amino-acid residues. The authors demonstrate that H<sub>2<\/sub>O<sub>2<\/sub>\u00a0oxidizes thiol groups (not shown) on these residues, forming sulfenic acid (SOH; not shown) and disulfide bonds. This oxidation triggers a conformational change and kinase activity, which, through unknown mechanisms, lead to the opening of calcium-ion (Ca<sup>2+<\/sup>) channels and Ca<sup>2+<\/sup>\u00a0influx into the cell, triggering intrinsic and systemic signalling pathways.<\/span><\/p>\n<\/figcaption><\/figure>\n<p>In the absence of eH<sub>2<\/sub>O<sub>2<\/sub>, the\u00a0<i>hpca1<\/i>\u00a0seedlings showed no differences from wild-type seedlings. However, their guard cells were less sensitive to eH<sub>2<\/sub>O<sub>2<\/sub>\u00a0than were those of the wild-type seedlings, showing lower than wild-type levels of Ca<sup>2+<\/sup>\u00a0influx in response to eH<sub>2<\/sub>O<sub>2<\/sub>. HPCA1 is therefore required to convert the eH<sub>2<\/sub>O<sub>2<\/sub>\u00a0signal into a physiological response. Moreover, the abscisic acid-dependent production of eH<sub>2<\/sub>O<sub>2<\/sub>\u00a0by guard cells was defective in the\u00a0<i>hpca1<\/i>\u00a0mutants. Of note, the function of HPCA1 in eH<sub>2<\/sub>O<sub>2<\/sub>\u00a0signalling was not limited to guard cells, and the authors provided evidence that eH<sub>2<\/sub>O<sub>2<\/sub>\u00a0signalling helps to transmit environmental signals to the nucleus of various cell types to regulate gene expression.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>Oxidation of Cys by H<sub>2<\/sub>O<sub>2<\/sub>\u00a0leads to the formation of a sulfenic acid (SOH), which is at the heart of reduction\u2013oxidation (redox) signalling. Sulfenic acids are rather unstable intermediates that can be further oxidized to sulfinic (SO<sub>2<\/sub>H) and sulfonic (SO<sub>3<\/sub>H) acid, or can undergo \u2018exchange reactions\u2019 to form disulfide bonds. For HPCA1 to function properly as a receptor for eH<sub>2<\/sub>O<sub>2<\/sub>, the Cys oxidation process must be readily reversible, re-forming thiol residues that can be oxidized again. However, the factors that mediate reduction of the oxidized HPCA1 are unknown. One candidate is a membrane-bound electron-transport system, such as the one that reduces an oxidized form of the antioxidant molecule ascorbic acid in the apoplast<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-020-00403-y?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR8\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">8<\/a><\/sup>. Membrane-bound and apoplastic thioredoxin-like proteins are also putative candidates, given that thioredoxin is a well-characterized reducing agent for oxidized Cys residues of proteins.<\/p>\n<p>&nbsp;<\/p>\n<aside class=\"recommended pull pull--left sans-serif\" data-label=\"Related\"><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02289-x\" data-track=\"click\" data-track-label=\"recommended article\"><img decoding=\"async\" class=\"recommended__image\" src=\"https:\/\/media.nature.com\/w400\/magazine-assets\/d41586-020-00403-y\/d41586-020-00403-y_17714002.jpg\" \/><\/a><\/p>\n<p class=\"recommended__title serif\">How plants perceive salt<\/p>\n<\/aside>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>Wu and colleagues have uncovered a receptor-kinase-mediated eH<sub>2<\/sub>O<sub>2<\/sub>\u00a0sensing mechanism that does not resemble any known eH<sub>2<\/sub>O<sub>2<\/sub>\u00a0receptors or sensors reported in other organisms. Nonetheless, HPCA1 might be part of a much wider portfolio of sensors used by plants to perceive and respond to environmental changes through ROS signals. The identification of such receptors has proved challenging, not least because likely candidates are members of very large protein families. Sophisticated screens, such as that used by Wu\u00a0<i>et al.<\/i>, will be required to tease out the family members that have ROS sensing and signalling roles. Once these sensors have been identified, it should be relatively easy to manipulate their properties to produce model plants and crops that have, for example, increased or depressed sensitivity to environmental H<sub>2<\/sub>O<sub>2<\/sub>\u00a0signals, and so show altered tolerance to environmental threats.<\/p>\n<p>Stomatal closure is not regulated just by H<sub>2<\/sub>O<sub>2<\/sub>; it is also a response to elevated atmospheric CO<sub>2<\/sub>\u00a0levels<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-020-00403-y?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR3\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">3<\/a><\/sup><sup>,<\/sup><sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-020-00403-y?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR9\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">9<\/a><\/sup>. It will be intriguing to see how proteins such as HPCA1 function in redox signalling networks that are likely to prepare plants for life in a future high-CO<sub>2<\/sub>\u00a0world. High CO<sub>2<\/sub>\u00a0levels can stimulate photosynthesis and depress photorespiration; changes in the photosynthesis:respiration ratio have a wide-ranging impact on cellular redox balance, because photorespiration generates a molecule of H<sub>2<\/sub>O<sub>2<\/sub>\u00a0in one organelle, the peroxisome, for every oxygen molecule assimilated in another organelle, the chloroplast, during photosynthesis. Perhaps other H<sub>2<\/sub>O<sub>2<\/sub>\u00a0sensors act together with HPCA1 to transmit organelle-specific redox messages to the nucleus, along with messages from the external face of the plasma membrane.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div class=\"emphasis\">doi: 10.1038\/d41586-020-00403-y<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>(\uc6d0\ubb38: <a href=\"https:\/\/www.nature.com\/articles\/d41586-020-00403-y?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29\">\uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; The discovery of a sensor that detects hydrogen peroxide at the surface of a cell provides insights into the mechanisms by which plant<a href=\"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4965\" class=\"more-link\">(more&#8230;)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[33,29],"tags":[],"class_list":["post-4965","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":951,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=951","url_meta":{"origin":4965,"position":0},"title":"To make plastic, just add blood","author":"biochemistry","date":"June 25, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 \u00a0 Red blood cells contain the iron-based molecule haemoglobin, which has now been harnessed to synthesize plastic. Credit: David Gregory & Debbie Marshall\/CC BY 4.0 To make plastic, just add blood Red blood cells harbour key ingredients for polymerization. \u00a0 \u00a0 Red blood cells normally\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3931,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3931","url_meta":{"origin":4965,"position":1},"title":"Cancer-cell death ironed out","author":"biochemistry","date":"July 27, 2019","format":false,"excerpt":"\u00a0 \u00a0 Ferroptosis is a form of cell death. The finding that cells that have certain mutations in the Hippo signalling pathway are susceptible to ferroptosis might offer a way to treat a cancer called mesothelioma. \u00a0 \u00a0 In the late twentieth century, there was a rise in a type\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1975,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1975","url_meta":{"origin":4965,"position":2},"title":"Intracellular gold nanoclusters boost energy conversion","author":"biochemistry","date":"October 2, 2018","format":false,"excerpt":"\u00a0 \u00a0 \uc0c8\ub85c\uc6b4 \ud615\ud0dc\uc758 '\ubc15\ud14c\ub9ac\uc544 \uc138\ud3ec \ub0b4\ubd80\ub85c \ub3c4\uc785\ub41c \uae08 \ub098\ub178\ubb3c\uc9c8 \uae30\ubc18 \uc5d0\ub108\uc9c0 \uc804\ud658 \uc2dc\uc2a4\ud15c'\uc5d0 \uad00\ud55c \ub0b4\uc6a9\uc785\ub2c8\ub2e4. (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) \u00a0 Intracellular gold nanoclusters act as photosensitizers, enabling non-photosynthetic bacteria to produce acetic acid from carbon dioxide in a more efficient and durable fashion. \u00a0 \u00a0 Driven by ever-growing consumption, humankind\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2250,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2250","url_meta":{"origin":4965,"position":3},"title":"Artificial cells gain communication skills","author":"biochemistry","date":"December 3, 2018","format":false,"excerpt":"\u00a0 \u00a0 No biologist would mistake the microscopic \u201ccells\u201d that chemical biologist Neal Devaraj and colleagues are whipping up at the University of California, San Diego (UCSD), for the real thing. Instead of the lipid membrane that swaddles our cells, these cell mimics wear a coat of plastic\u2014polymerized acrylate. And\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3568,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3568","url_meta":{"origin":4965,"position":4},"title":"Superconductivity near room temperature","author":"biochemistry","date":"May 23, 2019","format":false,"excerpt":"\u00a0 \u00a0 For a century, researchers have sought materials that superconduct \u2014 transport electricity without loss \u2014 at room temperature. Experimental data now confirm superconductivity at higher temperatures than ever before. \u00a0 Materials known as superconductors transmit electrical energy with 100% efficiency. They have a wide range of applications, such\u2026","rel":"","context":"In &quot;Let's Do Chemistry!&quot;","block_context":{"text":"Let's Do Chemistry!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=34"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4730,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4730","url_meta":{"origin":4965,"position":5},"title":"The immune system mimics a pathogen","author":"biochemistry","date":"November 2, 2019","format":false,"excerpt":"\u00a0 \u00a0 Microbes evolve diverse chemical strategies to survive in restrictive environments.\u00a0Mycobacterium tuberculosis\u00a0(Mtb) infection is a notable example of microbial persistence in a harsh milieu.\u00a0Mtb\u00a0causes tuberculosis (TB), a disease that kills more than 1.3 million people annually (1). On page 589 of this issue (2), Ruetz\u00a0et al.\u00a0describe how the immune\u2026","rel":"","context":"In &quot;'10. \uac1c\uccb4\uc758 \uc815\uccb4\uc131\uacfc \uac1c\uccb4 \uac04 \uc0c1\ud638\uc791\uc6a9'\uacfc '11. \uc9c4\ud654\uc758 \uba54\ucee4\ub2c8\uc998' \uad00\ub828&quot;","block_context":{"text":"'10. \uac1c\uccb4\uc758 \uc815\uccb4\uc131\uacfc \uac1c\uccb4 \uac04 \uc0c1\ud638\uc791\uc6a9'\uacfc '11. \uc9c4\ud654\uc758 \uba54\ucee4\ub2c8\uc998' \uad00\ub828","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=44"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_sharing_enabled":false,"jetpack_shortlink":"https:\/\/wp.me\/p9Xo1j-1i5","_links":{"self":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/4965","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4965"}],"version-history":[{"count":1,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/4965\/revisions"}],"predecessor-version":[{"id":4966,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/4965\/revisions\/4966"}],"wp:attachment":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4965"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4965"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4965"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}