{"id":496,"date":"2018-05-31T02:44:22","date_gmt":"2018-05-31T02:44:22","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=496"},"modified":"2023-07-05T15:47:40","modified_gmt":"2023-07-05T06:47:40","slug":"%ec%95%94%ec%84%b8%ed%8f%ac%eb%8f%84-%ed%95%98%eb%8a%94-%ed%85%8c%eb%8d%94%eb%a7%81","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=496","title":{"rendered":"\uc554\uc138\ud3ec\ub3c4 \ud558\ub294 \u2018\ud14c\ub354\ub9c1\u2019"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>(\uc6d0\ubb38: <a href=\"https:\/\/m.post.naver.com\/viewer\/postView.nhn?volumeNo=15842778&amp;memberNo=36405506\">\uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div class=\"se_component se_paragraph default\">\n<div class=\"se_sectionArea\">\n<div class=\"se_editArea\">\n<div class=\"se_viewArea se_ff_nanumgothic se_fs_T3 se_align-left\">\n<div class=\"se_editView\">\n<div class=\"se_textView\">\n<p class=\"se_textarea\">[\uc694\uc57d]<\/p>\n<p class=\"se_textarea\">\ubb34\uc120 \uc778\ud130\ub137\uc774 \ubd88\uac00\ub2a5\ud55c \uc0c1\ud669\uc5d0\uc11c \ub178\ud2b8\ubd81\uc774\ub098 \ud0dc\ube14\ub9bf\uc744 \uc778\ud130\ub137\uc5d0 \uc5f0\uacb0\ud574\uc57c \ud560 \ub54c, \ud754\ud788 \ud734\ub300\uc804\ud654\uc758\u00a0\ud14c\ub354\ub9c1(tethering) \uae30\ub2a5\uc744 \uc774\uc6a9\ud55c\ub2e4. \ud734\ub300\uc804\ud654\uc640 \ub2e4\ub978 \uae30\uae30\ub97c \ub9c8\uce58 \ubc27\uc904(tethers)\ub85c \uc5f0\uacb0\ud558\ub294 \uac83 \uac19\uc740 \uae30\ub2a5\uc774\ub2e4.\u00a0\ub180\ub78d\uac8c\ub3c4 \uc554\uc138\ud3ec \uc5ed\uc2dc \ud14c\ub354\ub9c1 \uae30\ub2a5\uc774 \uc788\ub2e4. \ud14c\ub354\ub9c1 \ub41c \uc554\uc138\ud3ec\ub294 \ud658\uc790\uc758 \uc0dd\uba85\uc744 \ub354\uc6b1 \uc704\ud611\ud55c\ub2e4. (2018.05)<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"se_component se_image default\">\n<div class=\"se_sectionArea se_align-left\">\n<div class=\"se_editArea\">\n<div class=\"se_viewArea\">\n<p><a class=\"se_mediaArea __se_image_link __se_link\" href=\"https:\/\/m.post.naver.com\/viewer\/postView.nhn?volumeNo=15842778&amp;memberNo=36405506#\" data-linktype=\"img\" data-linkdata=\"{&quot;imgId&quot; : &quot;SEDOC-1527491978739--1580758545_image_0_img&quot;, &quot;src&quot; : &quot;https:\/\/post-phinf.pstatic.net\/MjAxODA1MjhfMTIg\/MDAxNTI3NDkxNjk0NzUz.fxpzEVt9u8-Y14TzXxiR28HM8v6aj1NnQRXvZuWOozog.f2QOR5CUEzbiTdN5Iu9CQpVoXbxxhXIjVrldvuoeVjEg.JPEG\/%EB%84%A4%EC%9D%B4%EB%B2%84%ED%8F%AC%EC%8A%A4%ED%8C%8520180528.jpg&quot;, &quot;linkUse&quot; : &quot;false&quot;, &quot;link&quot; : &quot;&quot;}\"><img loading=\"lazy\" decoding=\"async\" id=\"SEDOC-1527491978739--1580758545_image_0_img\" class=\"se_mediaImage __se_img_el\" src=\"https:\/\/post-phinf.pstatic.net\/MjAxODA1MjhfMTIg\/MDAxNTI3NDkxNjk0NzUz.fxpzEVt9u8-Y14TzXxiR28HM8v6aj1NnQRXvZuWOozog.f2QOR5CUEzbiTdN5Iu9CQpVoXbxxhXIjVrldvuoeVjEg.JPEG\/%EB%84%A4%EC%9D%B4%EB%B2%84%ED%8F%AC%EC%8A%A4%ED%8C%8520180528.jpg?type=w1200\" alt=\"\" width=\"334\" height=\"300\" data-src=\"https:\/\/post-phinf.pstatic.net\/MjAxODA1MjhfMTIg\/MDAxNTI3NDkxNjk0NzUz.fxpzEVt9u8-Y14TzXxiR28HM8v6aj1NnQRXvZuWOozog.f2QOR5CUEzbiTdN5Iu9CQpVoXbxxhXIjVrldvuoeVjEg.JPEG\/%EB%84%A4%EC%9D%B4%EB%B2%84%ED%8F%AC%EC%8A%A4%ED%8C%8520180528.jpg?type=w1200\" data-attachment-id=\"I87qzoaOBflL838DgLNQydg5ebK4\" \/><\/a><\/p>\n<div class=\"se_editView\">\n<div><\/div>\n<div class=\"se_textView se_mediaCaption\"><span class=\"se_textarea\">\uc2e4\ud5d8\uc6a9\uae30\uc5d0\uc11c \uc9d1\ub2e8\uc73c\ub85c \uc790\ub77c\uace0 \uc788\ub294 \uc720\ubc29\uc554 \uc138\ud3ec(4T1)\ub97c \uad11\ud559\ud604\ubbf8\uacbd\uc73c\ub85c \ubcf8 \ubaa8\uc2b5. \uae34 \ubc27\uc904\ub4e4\uc774 \uc138\ud3ec\ub4e4 \uc0ac\uc774\ub97c \uc11c\ub85c \uc5f0\uacb0\ud558\uace0 \uc788\ub2e4. \uc640\uc774\uc988\ub9cc \uacfc\ud559\uc5f0\uad6c\uc18c \uc81c\uacf5<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div class=\"se_component se_paragraph default\">\n<div class=\"se_sectionArea\">\n<div class=\"se_editArea\">\n<div class=\"se_viewArea se_ff_nanumgothic se_fs_T3 se_align-left\">\n<div class=\"se_editView\">\n<div class=\"se_textView\">\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p class=\"se_textarea\">\uc554\uc138\ud3ec\uac00 \uae09\uc18d\ud788 \ubab8 \uacf3\uacf3\uc5d0 \ud37c\uc9c0\ub294 \uc804\uc774 \ud604\uc0c1\uc774 \ub098\ud0c0\ub098\ub294 \uc6d0\ub9ac\ub97c \uacfc\ud559\uc790\ub4e4\uc774 \ucc3e\uc544\ub0c8\ub2e4. \ubc27\uc904\ub85c \uc11c\ub85c\ub97c \ubb36\uc740 \ucc44 \ube60\ub978 \uc18d\ub3c4\ub85c\u00a0\uc774\ub3d9\ud55c\ub2e4\ub294 \uac83\uc774\ub2e4. \uce58\uba85\uc801\uc778 \uc804\uc774 \uc554\uc744 \uc815\ubcf5\ud558\uae30 \uc704\ud55c \uc0c8\ub85c\uc6b4 \ub3cc\ud30c\uad6c\uac00 \ub420 \uc218 \uc788\uc744\uc9c0 \uc8fc\ubaa9\ub41c\ub2e4.<\/p>\n<p>\uc774\uc2a4\ub77c\uc5d8 \uc640\uc774\uc988\ub9cc \uacfc\ud559\uc5f0\uad6c\uc18c\ub294 \ubca4\uc790\ubbfc \uac8c\uc774\uac70 \ubd84\uc790\uc138\ud3ec\uc0dd\ubb3c\ud559\uacfc \uad50\uc218 \uc5f0\uad6c\uc9c4\uc774 \uc11c\ub85c \uc5f0\uacb0\ub3fc \uc9d1\ub2e8\uc73c\ub85c \uc6c0\uc9c1\uc774\ub294 \uc554\uc138\ud3ec\uac00 \uac1c\ubcc4\ub85c\u00a0\uc6c0\uc9c1\uc77c \ub54c\ubcf4\ub2e4 \ub354 \ube60\ub974\uac8c \uc804\uc774\ub41c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc54c\uc544\ub0c8\ub2e4\uace0 \uc9c0\ub09c 10\uc77c \ubc1d\ud614\ub2e4. \uc554 \uc804\uc774\ub97c \ub458\ub7ec\uc2fc \uae30\uc874 \uac00\uc124\uc744 \ub4a4\uc9d1\ub294 \uc774\ubc88 \uc5f0\uad6c\u00a0\uacb0\uacfc\ub294 \uad6d\uc81c\ud559\uc220\uc9c0 \u2018\uc0ac\uc774\uc5b8\ud2f0\ud53d \ub9ac\ud3ec\ud2b8\u2019 \ucd5c\uc2e0\ud638\uc5d0 \ubc1c\ud45c\ub410\ub2e4.<\/p>\n<p>\uc554\uc138\ud3ec\ub294 \uc774\ub3d9 \ubc29\uc2dd\uc5d0 \ub530\ub77c \ud63c\uc790 \uc6c0\uc9c1\uc774\ub294 \uac83\uacfc \uc9d1\ub2e8\uc73c\ub85c \uc774\ub3d9\ud558\ub294 \uac83\uc758 \ub450 \uac00\uc9c0 \uc720\ud615\uc73c\ub85c \ub098\ub25c\ub2e4. \uc9c0\uae08\uae4c\uc9c0 \uacfc\ud559\uc790\ub4e4\uc740 \uac1c\ubcc4\uc801\uc73c\ub85c\u00a0\ud63c\uc790 \uc6c0\uc9c1\uc774\ub294 \uc554\uc138\ud3ec\uac00 \ub354 \uc704\ud5d8\ud558\ub2e4\uace0 \uc0dd\uac01\ud588\ub2e4. \uc774\ub4e4\uc740 \uc870\uc9c1\uc774\ub098 \uae30\uad00 \uc0ac\uc774\uc0ac\uc774\uc5d0 \uc788\ub294 \uacb0\ud569\uc870\uc9c1\uc744 \ud1b5\uacfc\ud574 \ud608\uad00\uacfc \ub9bc\ud504\uad00\uc73c\ub85c\u00a0\uc2a4\uba70\ub4e4\uae30 \ub54c\ubb38\uc774\ub2e4. \uc774\ub807\uac8c \uc2a4\uba70\ub4e0 \uc554\uc138\ud3ec\ub4e4\uc740 \ud608\uc561\uc774\ub098 \ub9bc\ud504\uc561\uc758 \ud750\ub984\uc744 \ud0c0\uace0 \uba3c \uae30\uad00\uc73c\ub85c \uc804\uc774\ub420 \uc218 \uc788\ub2e4. \uc774\ub4e4 \uc138\ud3ec\uac00\u00a0\uac1c\ubcc4\uc801\uc73c\ub85c \uc6c0\uc9c1\uc774\uae30 \uc704\ud574\uc120 E-\uce74\ub4dc\ud5e4\ub9b0\uc774\ub77c\uace0 \ubd88\ub9ac\ub294 \ub2e8\ubc31\uc9c8\uc774 \uc8fc\ubcc0\uc5d0 \uac70\uc758 \uc5c6\uc5b4\uc57c \ud55c\ub2e4. E-\uce74\ub4dc\ud5e4\ub9b0\uc740 \uc138\ud3ec\ub97c \uc81c\uc790\ub9ac\uc5d0\u00a0\ubd99\uc7a1\uc544\ub450\ub294 \uc5ed\ud560\uc744 \ud55c\ub2e4. \uc9d1\ub2e8\uc73c\ub85c \uc774\ub3d9\ud558\ub294 \uc554\uc138\ud3ec\ub294 \ub300\uac1c \uc8fc\ubcc0\uc5d0 E-\uce74\ub4dc\ud5e4\ub9b0\uc774 \uc0c1\ub2f9\ub7c9 \ub0a8\uc544 \uc788\ub2e4. \uadf8\ub798\uc11c \uacfc\ud559\uc790\ub4e4\uc740 \uc9d1\ub2e8 \uc774\ub3d9\u00a0\uc554\uc138\ud3ec\ub294 \uc6d0\ub798\uc758 \uc885\uc591 \uc704\uce58\uc5d0\uc11c \uba40\ub9ac \uac00\uc9c0 \ubabb\ud55c\ub2e4\uace0 \uc5ec\uacbc\ub2e4.<\/p>\n<p>\uc5f0\uad6c\uc9c4\uc740 \uc774\ub97c \ud655\uc778\ud558\uae30 \uc704\ud574 \uacf5\uaca9\uc801\uc73c\ub85c \uc804\uc774\uac00 \uc77c\uc5b4\ub098\ub294 \uc720\ubc29\uc554 \uc138\ud3ec\ub97c \uc2e4\ud5d8\uc6a9\uae30\uc5d0 \ub2f4\uc544 \uc800\uc18d \ud604\ubbf8\uacbd \ucd2c\uc601\uc73c\ub85c \uc131\uc7a5 \uacfc\uc815\uc744\u00a0\ucd94\uc801\ud588\ub2e4. \uc720\ubc29\uc554 \uc138\ud3ec\ub4e4\uc740 \uc774\ub3d9\uc774 \uac00\ub2a5\ud55c \ub2e8\uacc4\ub9cc\ud07c \ubc1c\ub2ec\ud558\uc790 \uc11c\ub85c\uc5d0\uac8c\uc11c \ub5a0\ub098\uac00\uae30 \uc2dc\uc791\ud588\ub2e4. \uadf8\ub7ec\ub098 \uc790\uc138\ud788 \ub4e4\uc5ec\ub2e4 \ubcf4\ub2c8 \uc11c\ub85c\u00a0\uc644\uc804\ud788 \ubd84\ub9ac\ub41c \uac8c \uc544\ub2c8\uc5c8\ub2e4. \uc138\ud3ec\ub4e4\ub07c\ub9ac \uae34 \ubc27\uc904(tethers)\ucc98\ub7fc \uc0dd\uae34 \uad6c\uc870\ub85c \uc774\uc5b4\uc838 \uc788\uc5c8\ub2e4. \uc774 \ubc27\uc904 \ub355\ubd84\uc5d0 \uc774\ub9ac\uc800\ub9ac\u00a0\uc790\uc720\ub86d\uac8c \uc6c0\uc9c1\uc774\uba74\uc11c\ub3c4 \uc11c\ub85c \uc5f0\uacb0\uc744 \uc720\uc9c0\ud558\uace0 \uc788\ub294 \uac83\uc774\ub2e4. \ub9c8\uce58 \ub178\ud2b8\ubd81\uc774\ub098 \ud0dc\ube14\ub9bf\uc774 \uac01\uc790 \uc778\ud130\ub137\uc744 \uc790\uc720\uc790\uc7ac\ub85c \ub4dc\ub098\ub4e4\uba74\uc11c\ub3c4\u00a0\ud734\ub300\uc804\ud654\uc640 \ud14c\ub354\ub9c1\uc73c\ub85c \uc5f0\uacb0\ub3fc \uc788\ub294 \uc0c1\ud669\ucc98\ub7fc \ub9d0\uc774\ub2e4. \uac01 \uc554\uc138\ud3ec\uac00 \ub2e4\ub978 \uc554\uc138\ud3ec\ub4e4\uc744 \uc55e\uc73c\ub85c \uc6c0\uc9c1\uc774\ub3c4\ub85d \uc790\uadf9\ud558\uba74\uc11c \uacb0\uad6d\uc740 \ubc27\uc904\ub85c\u00a0\uc5f0\uacb0\ub41c \uc554\uc138\ud3ec \uc804\uccb4\uac00 \uc9d1\ub2e8\uc73c\ub85c \uc774\ub3d9\ud558\uac8c \ub41c\ub2e4. \uac8c\uc774\uac70 \uad50\uc218\ub294 \uc554\uc138\ud3ec\ub4e4\uc758 \uc774\ub7f0 \uc0c1\ud0dc\ub97c \uc8fc\uc778 \uc190\uc5d0 \ub4e4\ub9b0 \ubaa9\uc904\uc774 \uc11c\ub85c \ub4a4\uc5c9\ud0a8 \uac1c\ub4e4\uc774\u00a0\ud55c\uaebc\ubc88\uc5d0 \uc0b0\ucc45\ud558\uace0 \uc788\ub294 \ubaa8\uc2b5\uc5d0\ub3c4 \ube44\uc720\ud588\ub2e4.<\/p>\n<p>\uc5f0\uad6c\uc9c4\uc740 \ubc27\uc904\ub85c \uc774\uc5b4\uc9c4 \uc554\uc138\ud3ec \uc9d1\ub2e8\uc758 E-\uce74\ub4dc\ud5e4\ub9b0 \uc218\uc900\uc744 \uc870\uc0ac\ud574\ubd24\ub2e4. \uadf8 \uacb0\uacfc \uc554\uc138\ud3ec\ub4e4\uc774 \uc790\uc720\ub86d\uac8c \ubd84\ub9ac\ub420 \uc218 \uc788\ub294 \uc544\uc8fc \ub0ae\uc740\u00a0\ub18d\ub3c4\uc640 \uc11c\ub85c \uac00\uae4c\uc6b4 \uac70\ub9ac\ub97c \uc720\uc9c0\ud560 \uc218 \uc788\ub294 \ub192\uc740 \ub18d\ub3c4\uc758 \uc808\ubc18 \uc815\ub3c4\uc600\ub2e4. \ub610 \ubc27\uc904\ub85c \uc774\uc5b4\uc9c4 \uc554\uc138\ud3ec \uc9d1\ub2e8\uc774 \ud63c\uc790 \uc6c0\uc9c1\uc774\ub294\u00a0\uc138\ud3ec\ub4e4\ubcf4\ub2e4 \uc774\ub3d9 \uc18d\ub3c4\ub294 \ub290\ub9ac\uc9c0\ub9cc, \ub354 \uba3c \uae30\uad00\uc5d0\uae4c\uc9c0 \uce68\ubc94\ud574 \uadf8\uacf3\uc5d0\uc11c \uc0c8\ub85c\uc6b4 \uc554 \uc870\uc9c1\uc744 \uc131\uc7a5\uc2dc\ucf30\ub2e4\uace0 \uc5f0\uad6c\uc9c4\uc740 \uc124\uba85\ud588\ub2e4. \uc804\uc774\uac00\u00a0\ub354 \uc798 \uc9c4\ud589\ub41c\ub2e4\ub294 \uc598\uae30\ub2e4.<\/p>\n<p>\uac8c\uc774\uac70 \uad50\uc218\ub294 \uc774\ubc88 \uc5f0\uad6c\ub97c \ubc14\ud0d5\uc73c\ub85c \uc804\uc774\uac00 \uc798 \ub418\ub294 \uc554\uc5d0 \ub300\ud574 \uc0c8\ub85c\uc6b4 \uc9c4\ub2e8\uc774\ub098 \uce58\ub8cc \ubc29\ubc95\uc744 \uac1c\ubc1c\ud560 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \ub0b4\ub2e4\ubcf4\uace0\u00a0\uc788\ub2e4. \uc554\uc138\ud3ec\uac00 \uc0c8\ub85c\uc6b4 \uc870\uc9c1\uc5d0 \ub3c4\ub2ec\ud588\uc744 \ub54c \uc774\ub4e4\uc744 \uc5f0\uacb0\ud558\ub294 \ubc27\uc904\ub4e4\uc774 \uc554\uc138\ud3ec\uac00 \ub300\ub7c9 \uc11c\uc2dd\ud560 \uc218 \uc788\ub3c4\ub85d \ub3d5\ub294 \uc5ed\ud560\ub3c4 \ud560 \uac70\ub77c\ub294\u00a0\uc608\uc0c1\uc744 \ub0b4\ub193\uae30\ub3c4 \ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774\ub97c \ud655\uc778\ud558\uae30 \uc704\ud55c \ud6c4\uc18d \uc5f0\uad6c\uc5d0 \ub4e4\uc5b4\uac14\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\uc6d0\ubb38 \ub9c1\ud06c<br \/>\n<a href=\"https:\/\/wis-wander.weizmann.ac.il\/life-sciences\/cancer-cells-seen-traveling-tethered-groups\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/wis-wander.weizmann.ac.il\/life-sciences\/cancer-cells-seen-traveling-tethered-groups<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) &nbsp; &nbsp; [\uc694\uc57d] \ubb34\uc120 \uc778\ud130\ub137\uc774 \ubd88\uac00\ub2a5\ud55c \uc0c1\ud669\uc5d0\uc11c \ub178\ud2b8\ubd81\uc774\ub098 \ud0dc\ube14\ub9bf\uc744 \uc778\ud130\ub137\uc5d0 \uc5f0\uacb0\ud574\uc57c \ud560 \ub54c, \ud754\ud788 \ud734\ub300\uc804\ud654\uc758\u00a0\ud14c\ub354\ub9c1(tethering) \uae30\ub2a5\uc744 \uc774\uc6a9\ud55c\ub2e4. \ud734\ub300\uc804\ud654\uc640 \ub2e4\ub978 \uae30\uae30\ub97c<a href=\"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=496\" 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novo DNA synthesis using polymerase-nucleotide conjugates","author":"biochemistry","date":"June 19, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 Published:\u00a018 June 2018 Nature Biotechnology \u00a0 \u00a0 \u00a0 Abstract \u00a0 Oligonucleotides are almost exclusively synthesized using the nucleoside phosphoramidite method, even though it is limited to the direct synthesis of\u00a0\u223c200 mers and produces hazardous waste. 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