{"id":4773,"date":"2019-11-07T12:02:04","date_gmt":"2019-11-07T03:02:04","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=4773"},"modified":"2019-11-07T12:04:12","modified_gmt":"2019-11-07T03:04:12","slug":"%eb%8c%80%ec%9e%a5%ec%95%94-%ec%84%b8%ed%8f%ac-%ec%8a%a4%ec%8a%a4%eb%a1%9c-%ec%a3%bd%ea%b2%8c-%ed%95%98%eb%8a%94-%ec%9c%a0%ec%a0%84%ec%9e%90-%eb%b0%9c%ea%b2%ac","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4773","title":{"rendered":"\ub300\uc7a5\uc554 \uc138\ud3ec \uc2a4\uc2a4\ub85c \uc8fd\uac8c \ud558\ub294 \uc720\uc804\uc790 \ubc1c\uacac"},"content":{"rendered":"

 <\/p>\n

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\ub3c5\uc77c\u00a0JMU<\/span>\u00a0\uc5f0\uad6c\uc9c4, \uc800\ub110 ‘\ub124\uc774\ucc98 \ud654\ud559 \uc0dd\ubb3c\ud559’\uc5d0 \ub17c\ubb38<\/p>\n

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\"\"<\/span><\/p>\n

\uc554\uc138\ud3ec \uc131\uc7a5 \uc720\ub3c4\ud558\ub294 \ud1a0\ub974 \uc720\uc804\uc790 \uc774\ubbf8\uc9c0[\uc564\uc544\ubc84 \ubbf8\uc2dc\uac04\ub300 \uc81c\uacf5]<\/em><\/span><\/p>\n

 <\/p>\n

\ub300\uc7a5\uc554 \uc885\uc591\uc758 90%\ub294 \uacf5\ud1b5\uc73c\ub85c APC<\/span>\u00a0\uc720\uc804\uc790 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac16\uace0 \uc788\ub2e4.<\/p>\n

\uc815\uc0c1 \uc138\ud3ec\uc5d0\ub294 \uc804\ud600 \uc601\ud5a5\uc744 \uc8fc\uc9c0 \uc54a\uace0,\u00a0APC<\/span>\u00a0\ub3cc\uc5f0\ubcc0\uc774\ub97c \uac00\uc9c4 \ub300\uc7a5\uc554 \uc138\ud3ec\ub9cc \uc2a4\uc2a4\ub85c \uc8fd\uac8c \uc720\ub3c4\ud558\ub294 \uc720\uc804\uc790\ub97c \ub3c5\uc77c \uacfc\ud559\uc790\ub4e4\uc774 \ubc1c\uacac\ud588\ub2e4.<\/p>\n

\uc728\ub9ac\uc6b0\uc2a4 \ub9c9\uc2dc\ubc00\ub9ac\uc548 \ubdd4\ub974\uce20\ubd80\ub974\ud06c \ub300\ud559\uad50(JMU<\/span>) \uc5f0\uad6c\uc9c4\uc740 \uc774\ub7f0 \ub0b4\uc6a9\uc758 \ub17c\ubb38\uc744 \uc800\ub110 ‘\ub124\uc774\ucc98 \ud654\ud559 \uc0dd\ubb3c\ud559(Nature<\/span>\u00a0Chemical<\/span>\u00a0Biology<\/span>)’\uc5d0 \ubc1c\ud45c\ud588\ub2e4.<\/p>\n

1402\ub144 \uc124\ub9bd\ub41c\u00a0JMU<\/span>\ub294 \uc878\uc5c5\uc0dd\uacfc \uad50\uc218\uc9c4\uc5d0\uc11c \uc5ec\ub7ec \uba85\uc758 \ub178\ubca8\uc0c1 \uc218\uc0c1\uc790\ub97c \ubc30\ucd9c\ud55c \uba85\ubb38 \uc5f0\uad6c \uc911\uc2ec \ub300\ud559\uc774\ub2e4.<\/p>\n

5\uc77c(\ud604\uc9c0\uc2dc\uac04) \uc628\ub77c\uc778(www.eurekalert.org<\/span>)\uc5d0 \uacf5\uac1c\ub41c \ubcf4\ub3c4\uc790\ub8cc\uc5d0 \ub530\ub974\uba74 \uc5f0\uad6c\ud300\uc774 \ubc1c\uacac\ud55c \uac74\u00a0eIF<\/span>2B5\ub77c\ub294 \uc720\uc804\uc790\ub85c, \uc7a5\ucc28\u00a0APC<\/span>\u00a0\ub3cc\uc5f0\ubcc0\uc774 \uc554 \uc885\uc591\uc758 ‘\uc544\ud0ac\ub808\uc2a4\uac74’\uc774 \ub420 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4.<\/p>\n

\ub17c\ubb38\uc758 \uc800\uc790 \uc911 \ud55c \uba85\uc778 \ubdd4\ub974\uce20\ubd80\ub974\ud06c \ub300\ud559 \ubcd1\uc6d0\uc758 \uc544\ub974\ubbfc \ube44\uac8c\ub9c1 \ubc15\uc0ac\ub294 “APC<\/span>\u00a0\uc720\uc804\uc790\uc758 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac00\uc9c4 \uc138\ud3ec\uc758 \uc0dd\uc874\uc5d0\ub9cc \uc911\uc694\ud558\uace0, \uac74\uac15\ud55c \uc138\ud3ec\uc640\ub294 \uc804\ud600 \uc0c1\uad00\uc774 \uc5c6\ub294 \uc720\uc804\uc790\ub97c \ucc3e\ub294 \ub370 \ucd08\uc810\uc744 \ub9de\ucdc4\ub2e4”\ub77c\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\ub3d9\ubb3c \uc2e4\ud5d8\uc5d0\uc11c \uc774 \uc720\uc804\uc790\ub97c \uc5b5\uc81c\ud588\ub354\ub2c8\u00a0APC<\/span>\u00a0\ub3cc\uc5f0\ubcc0\uc774 \ub300\uc7a5\uc554 \uc138\ud3ec\uc758 ‘\ud504\ub85c\uadf8\ub7a8 \uc138\ud3ec\uc0ac(programmed<\/span>\u00a0cell<\/span>\u00a0death<\/span>)’\uac00 \uc720\ub3c4\ub410\ub2e4. \uc774\ub294 \uc190\uc0c1\ub418\uac70\ub098 \ub178\ud654\ud55c \uc138\ud3ec\ub97c \uc2a4\uc2a4\ub85c \uc8fd\uac8c \ud574 \uc81c\uac70\ud558\ub294 \uac83\uc744 \ub9d0\ud55c\ub2e4.<\/p>\n

\uadf8\ub7ec\ub098 \uac74\uac15\ud55c \uc138\ud3ec\ub294\u00a0eIF<\/span>2B5 \uc720\uc804\uc790\ub97c \uc5b5\uc81c\ud574\ub3c4 \uc544\ubb34\ub7f0 \uc7a5\uc560\uac00 \uc0dd\uae30\uc9c0 \uc54a\uc558\ub2e4.<\/p>\n

\ub610\ud55c \uc774 \uc720\uc804\uc790\ub97c \uc644\uc804\ud788 \ud65c\uc131\ud654\ud558\uc9c0\ub9cc \uc54a\uc73c\uba74\u00a0APC<\/span>\u00a0\ub3cc\uc5f0\ubcc0\uc774\ub97c \uac00\uc9c4 \uc0dd\uc950\ub3c4 \uadf8\ub9ac \ube68\ub9ac \ub300\uc7a5\uc554\uc5d0 \uac78\ub9ac\uc9c0 \uc54a\uc558\uace0, \uc124\uc0ac \ub300\uc7a5\uc554\uc774 \uc0dd\uaca8\ub3c4 \ud6e8\uc52c \ub354 \uc624\ub798 \uc0b4\uc558\ub2e4.<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n

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 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

    \ub3c5\uc77c\u00a0JMU\u00a0\uc5f0\uad6c\uc9c4, \uc800\ub110 ‘\ub124\uc774\ucc98 \ud654\ud559 \uc0dd\ubb3c\ud559’\uc5d0 \ub17c\ubb38     \uc554\uc138\ud3ec \uc131\uc7a5 \uc720\ub3c4\ud558\ub294 \ud1a0\ub974 \uc720\uc804\uc790 \uc774\ubbf8\uc9c0[\uc564\uc544\ubc84 \ubbf8\uc2dc\uac04\ub300 \uc81c\uacf5]   \ub300\uc7a5\uc554 \uc885\uc591\uc758 90%\ub294 \uacf5\ud1b5\uc73c\ub85c APC\u00a0\uc720\uc804\uc790 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'\uc815\ud06c\u00a0DNA'\u00a0\ub610\ub294 '\ubd88\uc6a9\u00a0DNA'\ub77c\uace0 \ud55c\ub2e4. \uc778\uac04 \uc720\uc804\uccb4\uc5d0\ub294 \uc57d 32\uc870 \uac1c\uc758 \uc5fc\uae30\uc30d(chemical\u00a0pairs)\uc774 \uc788\ub294\ub370 \uc774\uc911 \ub300\ub7b5 98%\uac00 \uc815\ud06c\u00a0DNA\ub85c \ucd94\uc815\ub41c\ub2e4. \uace0\ub4f1\uc0dd\ubb3c\uc77c\uc218\ub85d \uc815\ud06c\u00a0DNA\uac00 \ub9ce\uc9c0\ub9cc, \uc9c0\uae08\uae4c\uc9c4 \uc65c \uc874\uc7ac\ud558\ub294\uc9c0\uc870\ucc28 \ubca0\uc77c\uc5d0 \uc2f8\uc5ec \uc788\uc5c8\ub2e4. \uadf8\ub7f0\ub370 \uc774\ub7f0\u00a0DNA\uc5d0 '\uc815\ud06c(\uc4f0\ub808\uae30)'\ub77c\ub294 \ud45c\ud604\uc740 \uc774\uc81c \uc4f0\uae30 \uc5b4\ub835\uac8c \ub410\ub2e4. \uc720\uc804\uc790 \ubc1c\ud604 \uc2dc \uadf8 \uc704\uce58\uc640 \ud0c0\uc774\ubc0d \ub4f1\uc744 \uc774\ub4e4\u00a0DNA\uac00 \uc81c\uc5b4\ud55c\ub2e4\ub294 \uac8c\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3661,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3661","url_meta":{"origin":4773,"position":2},"title":"“\uadfc\uc721 \uc138\ud3ec \uc815\uc0c1 \ubd84\ud654 \uc81c\uc5b4\ud558\ub294 \uc720\uc804\uc790 \uc870\ud569 \ubc1c\uacac”","author":"biochemistry","date":"June 6, 2019","format":false,"excerpt":"\u00a0 \u00a0 \uce90\ub098\ub2e4 \uc694\ud06c\ub300 \uc5f0\uad6c\uc9c4 \ubcf4\uace0\uc11c T\uc138\ud3ec \uacf5\uaca9 \ubc1b\ub294 \uc554\uc138\ud3ec[\uac8c\ud2f0\uc774\ubbf8\uc9c0\ubc45\ud06c \uc81c\uacf5] \u00a0 \uadfc\uc721 \uc138\ud3ec\uc758 \ubd84\ud654\uc640 \uc131\uc7a5, \uc190\uc0c1 \ubcf5\uad6c \ub4f1\uc744 \uc81c\uc5b4\ud558\ub294 \uc720\uc804\uc790 \uc870\ud569\uc744 \uce90\ub098\ub2e4 \uacfc\ud559\uc790\ub4e4\uc774 \ubc1c\uacac\ud588\ub2e4. \uc774\ub4e4 \uc720\uc804\uc790\uc5d0 \uc774\uc0c1\uc774 \uc0dd\uae30\uba74 \uc545\uc131 \ud6a1\ubb38\uadfc\uc721\uc885 \uac19\uc740 \uc5f0\ud55c \uc870\uc9c1 \uc554\uc774 \uc0dd\uae38 \uc218 \uc788\ub2e4. \uce90\ub098\ub2e4 \uc694\ud06c\ub300 \ub300\ud559\uc6d0\uc758 \uc874 \ub9e5\ub354\ubaa8\ud2b8 \uc0dd\ubb3c\ud559 \uad50\uc218\ud300\uc740 \uc774\ub7f0 \ub0b4\uc6a9\uc758 \uc5f0\uad6c\ubcf4\uace0\uc11c\ub97c \uc800\ub110 '\uc140\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3831,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3831","url_meta":{"origin":4773,"position":3},"title":"\uc778\uccb4 \uba74\uc5ed\ubc18\uc751 \uc628\u00b7\uc624\ud504 \ud558\ub294 ‘\ub2e8\ubc31\uc9c8 \uc2a4\uc704\uce58’ \ubc1c\uacac","author":"biochemistry","date":"June 25, 2019","format":false,"excerpt":"\u00a0 \u00a0 \ub3c5\uc77c \ubb8c\ud5e8 \uacf5\ub300 \uc5f0\uad6c\uc9c4 \ubcf4\uace0\uc11c \uae38 \uc548\ub0b4 \ubc1b\ub4ef \ub530\ub77c\uac00\ub294 \uba74\uc5ed\uc138\ud3ec\ub4e4 [\uc0ac\uc774\uc5b8\uc2a4 \uc81c\uacf5] \u00a0 \uc778\uccb4\uac00 \ubc14\uc774\ub7ec\uc2a4\uc5d0 \uac10\uc5fc\ub418\uba74 \ucd5c\uace0 \uacbd\uacc4 \uc218\uc704\uc758 \uba74\uc5ed\uccb4\uacc4\ub97c \uc791\ub3d9\ud574 \ub2e4\uc591\ud55c \uc885\ub958\uc758 \uba74\uc5ed\uc138\ud3ec\ub97c \uac10\uc5fc \uc138\ud3ec\ub4e4\uc5d0 \ub300\uac70 \ud22c\uc785\ud55c\ub2e4. \ud558\uc9c0\ub9cc \uc77c\ub2e8 \ubc14\uc774\ub7ec\uc2a4 \ud1f4\uce58\uc5d0 \uc2e4\ud328\ud558\uba74 \uba74\uc5ed\uc138\ud3ec\uc758 \uacf5\uaca9 \uae30\ub2a5\uc740 \uadf9\ub3c4\ub85c \uc5b5\uc81c\ub41c\ub2e4. \uba74\uc5ed\uc138\ud3ec\uc758 \uc774\ub7f0 \uc804\ud22c\ub825 '\uace0\uac08(exhaustion)'\uc740, \ubc14\uc774\ub7ec\uc2a4 \uce68\ud22c\uc5d0 \ub9de\uc11c \uac00\ub3d9\ub410\ub358 \ube44\uc0c1 \uccb4\uc81c\uc5d0\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1347,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1347","url_meta":{"origin":4773,"position":4},"title":"\uc720\uc804\uc790\uac00\uc704\ub294 \ub9cc\ub2a5?\u2026\uc548\uc804\uc131 \uacbd\uace0 \uc787\ub530\ub77c","author":"biochemistry","date":"August 13, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 \uc720\uc804\uc790\uce58\ub8cc \uc548\uc804\uc131 \uc5f0\uad6c \uc5b4\ub514\uae4c\uc9c0 \uc720\uc804\uc790\uac00\uc704, \uc815\ud655\ud788 \ud45c\uc801 \uc798\ub77c\ub3c4 DNA\u00a0\uacb0\uc2e4\u00b7\uc0bd\uc785\u00b7\uc7ac\ubc30\uc5f4 \ubd80\uc791\uc6a9 \ubcc0\uc774\uc720\ubc1c \uba54\ucee4\ub2c8\uc998 \uaddc\uba85 \uc0c8 \uacfc\uc81c \uac00\uc704 \uc791\ub3d9 \uc774\ud6c4 \uc138\ud3ec \ub300\uc751 \ubcf5\uc7a1 \uc554 \uc704\ud5d8\uacfc\uc758 \uc0c1\uad00\uc131 \ud655\uc778\ub418\uae30\ub3c4 \uc9c0\ub098\uce5c 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\u00a0 \u00a0 \ubd88\ub85c\uc7a5\uc0dd\uc740 \uc778\uac04\uc758 \uc624\ub798\ub41c \uafc8\uc774\ub2e4. \uace0\ub300 \uc218\uba54\ub974\uc758 \uae38\uac00\uba54\uc2dc \uc2e0\ud654\ubd80\ud130 \uc9c4\uc2dc\ud669\uc758 \ubd88\ub85c\ucd08 \uc774\uc57c\uae30\uae4c\uc9c0 \ube44\ub85d \ud5db\ub41c \uafc8\uc774\uae30\ub294 \ud558\uc9c0\ub9cc, \ub9ce\uc740 \uc774\ub4e4\uc774 \ub299\uc9c0 \uc54a\uac70\ub098 \ud639\uc740 \uc8fd\uc9c0 \uc54a\ub294 \ube44\ubc95\uc744 \ucc3e\uc544 \ud5e4\ub9f8\ub2e4. \uc0ac\uc2e4 \ud604\uc7ac\ub97c \uc0ac\ub294 \uc6b0\ub9ac\ub4e4\ub3c4 \ub2e4\ub974\uc9c0 \uc54a\uc740 \uc778\uac04\uc774\ub2e4. \ube44\ub85d \ubd88\ub85c\ucd08\ub97c \ucc3e\uc544 \ud5e4\ub9e4\uc9c0\ub294 \uc54a\uc9c0\ub9cc, \ub354\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do 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