{"id":4701,"date":"2019-10-31T12:07:22","date_gmt":"2019-10-31T03:07:22","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=4701"},"modified":"2023-07-20T18:24:03","modified_gmt":"2023-07-20T09:24:03","slug":"%ed%95%ad%ec%b2%b4-%ec%9d%b4%ec%95%bc%ea%b8%b0","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4701","title":{"rendered":"\ud56d\uccb4 \uc774\uc57c\uae30"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\uaca8\uc6b8\uc774 \uc9c0\ub098\uba74\uc11c \ub0ae\uc774 \uae38\uc5b4\uc9c0\uba74 \ub354 \uc774\uc0c1 \ucc2c\ubc14\ub78c\uc5d0 \ucf54\uac00 \uc2dc\ub9ac\uc9c0 \uc54a\uc8e0. \ud558\uc9c0\ub9cc \ub0a0\uc528\uac00 \ub530\ub73b\ud574\uc9c0\ub294 \uc2dc\uae30\uc5d0 \uace4\uacbd\uc5d0 \ucc98\ud558\ub294 \uc0ac\ub78c\ub4e4\uc774 \uc788\uc5b4\uc694. \uadf8\ub798\uc11c \ub9e4\ub144 \ubd04\ub9cc \ub418\uba74 \uc804\uc7c1\uc744 \uc900\ube44\ud558\ub4ef\uc774 \uc758\ub8cc\uc6a9 \ub9c8\uc2a4\ud06c\ub97c \uad6c\uc785\ud558\uace0 \uc57d\uc744 \uc313\uc544\ub193\uc544\uc57c \ud558\uc8e0. \uc774\ub4e4\uc740 \ubc14\ub85c \uc2ec\ud55c \uc54c\ub808\ub974\uae30\ub97c \uac00\uc9c4 \ud658\uc790\ub4e4\uc778\ub370 \uc774\ub4e4\uc5d0\uac90 \uacc4\uc808\uc758 \ubcc0\ud654 \uc790\uccb4\uac00 \uc2ec\uac01\ud55c \uc704\ud611\uc774 \ub420 \uc218 \uc788\ub2f5\ub2c8\ub2e4. \uc774\uc640 \uac19\uc740 \uc54c\ub808\ub974\uae30\uc758 \uc6d0\uc778\uc740 \uc6b0\ub9ac\uc758 \uba74\uc5ed\uccb4\uacc4\uc640 \uad00\ub828\uc774 \uc788\uc5b4\uc694<\/p>\n<p>&nbsp;<\/p>\n<p>\uba74\uc5ed\uccb4\uacc4\uc758 \uae30\ubcf8\uc801\uc778 \uc5ed\ud560\uc740 \uc6b0\ub9ac \ubab8\uc744 \uc704\ud5d8\ud558\uc9c0 \uc54a\uac8c \uc9c0\ucf1c\uc8fc\ub294 \uac83\uc774\ub78d\ub2c8\ub2e4. \uba74\uc5ed\u00a0\uccb4\uacc4\uc5d0\uc11c\u00a0\uac00\uc7a5\u00a0\uc911\uc694\ud55c\u00a0\uc694\uc18c\ub294\u00a0\u2018\uc801\uc751\u00a0\uba74\uc5ed\u2019\uc774\ub77c\ub294\u00a0\ubc18\uc751\uc774\uc5d0\uc694.\u00a0\uc801\uc751\u00a0\uba74\uc5ed\u00a0\uc138\ud3ec\ub4e4\uc740\u00a0\ubb38\uc81c\ub97c\u00a0\uc77c\uc73c\ud0a4\ub294\u00a0\ubc14\uc774\ub7ec\uc2a4\ub098\u00a0\ubc15\ud14c\ub9ac\uc544\uac00\u00a0\ub2e4\uc74c \ubc88\uc5d0\ub294\u00a0\ubab8\u00a0\uc548\uc5d0\u00a0\uce68\uc785\ud558\uc9c0\u00a0\ubabb\ud558\ub3c4\ub85d\u00a0\u2018\uae30\uc5b5\u2019\ud55c\ub2f5\ub2c8\ub2e4. \ud558\uc9c0\ub9cc\u00a0\uac00\ub054\uc740\u00a0\uc801\uc751\u00a0\uba74\uc5ed\uc5d0\u00a0\ubb38\uc81c\uac00\u00a0\uc0dd\uaca8\uc11c\u00a0\uc5c9\ub6b1\ud55c\u00a0\uc0c1\ub300\ub97c\u00a0\uacf5\uaca9\ud558\uae30\ub3c4\u00a0\ud574\uc694.\u00a0\uadf8\ub798\uc11c\u00a0\uc8fc\ubcc0\u00a0\ud658\uacbd\uc5d0\uc11c\u00a0\ubcfc\u00a0\uc218\u00a0\uc788\ub294\u00a0\uc77c\ubd80\u00a0\ubb34\ud574\ud55c\u00a0\ubb3c\uc9c8\uc774\ub098\u00a0\uc2dd\ud488\uc774\u00a0\uc54c\ub808\ub974\uae30\ub97c\u00a0\uc720\ubc1c\ud560\u00a0\uc218\u00a0\uc788\uc5b4\uc694.<\/p>\n<p>&nbsp;<\/p>\n<p>\uc774\u00a0\uacfc\uc815\uc5d0\ub294\u00a0\uc801\uc751\u00a0\uba74\uc5ed\uc744\u00a0\u2018\uc9c0\ud718\u2019\ud558\ub294\u00a0\uc138\ud3ec\uc778, B \uc138\ud3ec(\uace8\uc218, bone marrow\uc5d0\uc11c \uc720\ub798)\ub77c\uace0\ub3c4 \ubd88\ub9ac\ub294,\u00a0B-\ub9bc\ud504\uad6c\uc5d0\uc11c\u00a0\uc0dd\uc0b0\ub418\ub294\u00a0\ud2b9\uc218\ud55c\u00a0\ud56d\uccb4\u00a0\ubd84\uc790\uac00\u00a0\uad00\ub828\ub418\uc5b4\u00a0\uc788\uc5b4\uc694.\u00a0B-\ub9bc\ud504\uad6c\ub294\u00a0\uc138\ud3ec\u00a0\ud45c\uba74\uc758\u00a0\uace0\uc720\ud55c\u00a0\ubaa8\uc591\uc744\u00a0\ubcf4\uace0\u00a0\ud574\ub85c\uc6b4\u00a0\ubbf8\uc0dd\ubb3c \ub4f1\uc744\u00a0\uc778\uc2dd\ud55c\ub2f5\ub2c8\ub2e4.\u00a0\uacfc\ud559\u00a0\uc218\uc0ac\uad00\ub4e4\uc774\u00a0\ubc94\uc8c4\uc790\uc758\u00a0\uc9c0\ubb38\u00a0\uae30\ub85d\uc744\u00a0\uac00\uc9c0\uace0\u00a0\uc788\ub4ef\uc774\u00a0B-\ub9bc\ud504\uad6c\ub3c4\u00a0\uc6b0\ub9ac\uac00\u00a0\uc774\ubbf8\u00a0\uacaa\uc5c8\ub358\u00a0\ubaa8\ub4e0\u00a0\uac10\uc5fc\uc5d0\u00a0\ub300\ud55c\u00a0\uae30\ub85d\uc744\u00a0\ud544\uc694\ub85c\u00a0\ud558\uc8e0.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\ud56d\uccb4\uc5d0 \ub300\ud574\uc11c \uc880\ub354 \uc790\uc138\ud788 \uc54c\uc544\ubcfc\uae4c\uc694?<\/p>\n<p>&nbsp;<\/p>\n<p>\ud56d\uccb4(\u6297\u9ad4, antibody, Ab, immunoglobulin, Ig)\ub294 \ud56d\uc6d0\uacfc \ud2b9\uc774\uc801 \uacb0\ud569\uc744 \ud558\uc5ec \ud56d\uc6d0-\ud56d\uccb4 \ubc18\uc751\uc744 \uc77c\uc73c\ud0a4\ub294 \ubb3c\uc9c8\uc774\uc5d0\uc694. \ud608\uc561\uc758 \ud608\uc18c\ud310\uc740 \uc801\ud608\uad6c\uc640 \ubc18\uc751\ud558\uc5ec \uc751\uc9d1\ud558\uace0 \ud0dc\uc5b4\ub0a0 \ub54c\ubd80\ud130 \ud56d\uc0c1 \uac00\uc9c0\uace0 \uc788\uc73c\ubbc0\ub85c \uc815\uc0c1 \ud56d\uccb4 \ub610\ub294 \ub3d9\uc885 \ud56d\uccb4\ub77c \ud558\uace0, \uc774\ub294 \ud608\uc561\ud615\uacfc \uad00\ub828\uc774 \uc788\uc5b4\uc694. \uba74\uc5ed \uccb4\uacc4\uc5d0\uc11c \uc138\uade0\uc774\ub098 \ubc14\uc774\ub7ec\uc2a4\uac19\uc740 \uc678\ubd80\ud56d\uc6d0\ub4e4\uacfc \ud2b9\uc774\uc801 \uacb0\ud569\uc744 \ud558\uc5ec \ud56d\uc6d0\uc744 \uc778\uc2dd\ud558\uac8c\ud558\uace0 \ub3d9\uc2dc\uc5d0 \ubb34\ub825\ud654\uc2dc\ud0a4\ub294 \uc791\uc6a9\uc744 \ud558\ub294 \uba74\uc5ed\uae00\ub85c\ubd88\ub9b0\uc740 \uba74\uc5ed \ud56d\uccb4\ub77c\uace0 \ud558\ub294\ub370 \ubcf4\ud1b5 \ud56d\uccb4\ub77c\uace0 \ud558\uba74 \uba74\uc5ed \ud56d\uccb4\ub97c \ub73b\ud55c\ub2f5\ub2c8\ub2e4. \ud56d\uccb4\uc640 \uba74\uc5ed\uae00\ub85c\ubd88\ub9b0\uc740 \ub3d9\uc77c\ud55c \uc758\ubbf8\ub85c\uc11c \uba74\uc5ed\uae00\ub85c\ubd88\ub9b0\uc740 \ud56d\uccb4\ub85c\uc11c \uc791\uc6a9\ud558\ub294 \ub2f9\ub2e8\ubc31\uc9c8\uc744 \ub73b\ud574\uc694. \uc5ec\ub7ec \uc885\ub958\uc758 \uba74\uc5ed\uae00\ub85c\ubd88\ub9b0\uc774 \uc788\ub294\ub370 \uc774\ub4e4\uc744 \uba74\uc5ed\uae00\ub85c\ubd88\ub9b0 \uc0c1\uacfc(\u4e0a\u79d1)(immunoglobulin superfamily)\ub85c \ubb36\uc5b4 \ubd84\ub958\ud558\uace0 \uc788\uc5b4\uc694. \ud56d\uccb4\ub294 \ud608\uc561\uacfc \uc870\uc9c1\uc561 \ubfd0\ub9cc \uc544\ub2c8\ub77c \ubd84\ube44\ubb3c(\ub208\ubb3c \ub4f1)\uc5d0\uc11c\ub3c4 \ubc1c\uacac\ub418\ub294\ub370 \ud50c\ub77c\uc988\ub9c8 \uc138\ud3ec\uc5d0\uc11c \uc0dd\uc131\ub418\uace0 \ubd84\ube44\ub41c\ub2e4\uace0 \ud574\uc694. \ud50c\ub77c\uc988\ub9c8 \uc138\ud3ec\ub294 \uba74\uc5ed\uacc4\uc758 B\uc138\ud3ec\uac00 T\uc138\ud3ec\uc640\uc758 \uc0c1\ud638\uc791\uc6a9\ud558\ub294 \uac00\uc6b4\ub370 B\uc138\ud3ec\uac00 \ud2b9\uc815 \ud56d\uc6d0\uacfc \uacb0\ud569\ud558\uc5ec \ubd84\ud654\ub41c \uc138\ud3ec\uc774\uace0, \uac01 \ud56d\uccb4\ub294 \ud2b9\uc774\uc801\uc73c\ub85c \ud56d\uc6d0\uacfc \uacb0\ud569\ud558\uba70 \ud50c\ub77c\uc988\ub9c8 \uc138\ud3ec\uc5d0 \uc758\ud55c \ud56d\uccb4\uc758 \uc0dd\uc0b0\uc740 \uccb4\uc561\uc131 \uba74\uc5ed\uc774\ub77c\uace0\ub3c4 \ubd88\ub9b0\ub2f5\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p>\uc544\ub798\uc758 \uadf8\ub9bc\uc5d0\uc11c \ubcf4\ub294 \ubc14\uc640 \uac19\uc774, \ud56d\uccb4\uc758 \uae30\ubcf8 \uad6c\uc870\ub294 Y\uc790\ud615\uc758 \ub2e8\ubc31\uc9c8\uc774\uba70, Y\uc790\uc758 \uc704\ucabd \ub450 \uac00\uc9c0\uc5d0 \ud56d\uc6d0\uacfc \uacb0\ud569\ud560 \uc218 \uc788\ub294 \ud2b9\uc774\uc801 \uad6c\uc870\ub97c \uac00\uc9c0\uace0 \uc788\uc5b4\uc694. \uc774\ub7ec\ud55c \ud2b9\uc774\uc801 \uad6c\uc870\ub294\u00a0\uba74\uc5ed\u00a0\uc138\ud3ec\uc5d0\uc11c \uc77c\uc5b4\ub098\ub294\u00a0DNA\u00a0\uc218\uc900\uc5d0\uc11c\uc758 \uc720\uc804\uc790 \uc7ac\ubc30\uc5f4\uc5d0 \uc758\ud574 \uc0c1\uc0c1\ud560 \uc218 \uc5c6\uc744 \uc815\ub3c4\ub85c \ub9ce\uc740 \uac00\uc9d3\uc218\ub97c \uac00\uc9c8 \uc218 \uc788\uc73c\ubbc0\ub85c, \ub2e4\uc591\ud55c \ud56d\uc6d0\uc5d0 \ub300\uc751\ud560 \uc218 \uc788\ub2f5\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p>\ud56d\uccb4\ub294 \ube44\uad50\uc801 \ud070 \ubd84\uc790\ub7c9\uc744 \uac00\uc9c4 \ub2e8\ubc31\uc9c8\ub85c\uc11c \uc544\ubbf8\ub178\uc0b0\uae30\uc5d0 \ub2f9\uc0ac\uc2ac\uc774 \uacb0\ud569\ud558\uace0 \uc788\uc5b4\uc694.\u00a0\ub300\ubd80\ubd84\uc758 \uba74\uc5ed\uae00\ub85c\ubd88\ub9b0 \uc0c1\uacfc(\u4e0a\u79d1) \ud56d\uccb4\ub4e4\uc740 \uc544\ubbf8\ub178\uc0b0\uc758 N-\ub9d0\ub2e8\uc5d0 \uacb0\ud569\ud558\uace0 \uc788\uc9c0\ub9cc IgA1\uc640 IgD \uacbd\uc6b0\ub9cc O-\ub9d0\ub2e8\uc5d0 \uacb0\ud569\ud558\uace0 \uc788\ub2e4\uace0 \ud574\uc694. \uac01 \ud56d\uccb4\uc758 \uae30\ubcf8 \ub2e8\uc704\ub294 \uac01\uac01 \uacbd\uc0ac\uc2ac 2\uac1c\uc640 \uc911\uc0ac\uc2ac 2\uac1c\uac00 \uc774\ud669\ud654 \uacb0\ud569\uc744 \ud558\uc5ec \uc774\ub8e8\uc5b4\uc9c4 Y\uc790 \ubaa8\uc591\uc744 \ud55c\u00a0\ub2e8\ub7c9\uccb4\u00a0\ubd84\uc790\uc774\uba70 \ub2e8\ub7c9\uccb4\uac00 1- 5\uac1c\uae4c\uc9c0 \ubaa8\uc5ec \ud558\ub098\uc758 \ud56d\uccb4\ub97c \uad6c\uc131\ud55c\ub2f5\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"4702\" data-permalink=\"https:\/\/biochemistry.khu.ac.kr\/lab\/?attachment_id=4702\" data-orig-file=\"https:\/\/biochemistry.khu.ac.kr\/lab\/wp-content\/uploads\/2019\/10\/001.jpg\" data-orig-size=\"545,468\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"001\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/biochemistry.khu.ac.kr\/lab\/wp-content\/uploads\/2019\/10\/001-300x258.jpg\" data-large-file=\"https:\/\/biochemistry.khu.ac.kr\/lab\/wp-content\/uploads\/2019\/10\/001.jpg\" class=\"wp-image-4702 size-full aligncenter\" src=\"http:\/\/163.180.4.222\/lab\/wp-content\/uploads\/2019\/10\/001.jpg\" alt=\"\" width=\"545\" height=\"468\" srcset=\"https:\/\/biochemistry.khu.ac.kr\/lab\/wp-content\/uploads\/2019\/10\/001.jpg 545w, https:\/\/biochemistry.khu.ac.kr\/lab\/wp-content\/uploads\/2019\/10\/001-300x258.jpg 300w\" sizes=\"auto, (max-width: 545px) 100vw, 545px\" \/><\/p>\n<p style=\"text-align: center;\">\ud56d\uccb4\uc758 \ucef4\ud4e8\ud130 \uc774\ubbf8\uc9c0. \uc18c\ub9ac\uad7d\uc1e0\ucc98\ub7fc \uac08\ub77c\uc9c4 \ubd80\ubd84 \uc591\ucabd \ub05d\uc774 \ud56d\uc6d0\uacfc \uacb0\ud569\ud55c\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\uc989, B-\ub9bc\ud504\uad6c\uac00 \ub9cc\ub4e0 \ud56d\uccb4 \ubd84\uc790\ub294 \ub05d\uc774 \ub450 \uac00\ub2e5\uc73c\ub85c \uac08\ub77c\uc9c4 \uc18c\ub9ac\uad7d\uc1e0\ucc98\ub7fc \uc0dd\uacbc\uc5b4\uc694. \ud56d\uccb4 \u2018\uc18c\ub9ac\uad7d\uc1e0\u2019\uc758 \uc190\uc7a1\uc774 \ubd80\ubd84\uc740 \ub300\ubd80\ubd84 \ubaa8\uc591\uc774 \uac70\uc758 \ube44\uc2b7\ud574\uc694. \ub9e1\uace0 \uc787\ub294 \uc11c\ub85c \ub2e4\ub978 \uc784\ubb34\uc5d0 \uc801\ud569\ud558\ub3c4\ub85d \ub2e4\uc12f \uac00\uc9c0 \ubcc0\uc885 \uc815\ub3c4\ub9cc\uc774 \uc874\uc7ac\ud560 \ubfd0\uc774\uc9c0\uc694. \uba74\uc5ed \u2018\uc801\uc751\u2019\uc758 \ud2b9\uc131\uc740 \uc591 \ub05d\uc758 \u2018\uac00\ub2e5\u2019 \ubd80\ubd84\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9c4\ub2f5\ub2c8\ub2e4. \uac01 B-\ub9bc\ud504\uad6c\ub294 \ud56d\uccb4\uc758 \ud615\uc131\uc5d0 \uad00\uc5ec\ud558\ub294 \uc720\uc804\uc790\ub97c \ub2e4\uc591\ud55c \ub3cc\uc5f0\ubcc0\uc774\uc5d0 \ub178\ucd9c\uc2dc\ud0ac \uc218 \uc788\uae30 \ub54c\ubb38\uc5d0 \ud56d\uccb4 \uac00\ub2e5\uc758 \ubaa8\uc591\uc774 \ub2e4\uc591\ud574\uc838\uc694. \uadf8 \uacb0\uacfc \uc5ec\ub7ec \uac00\uc9c0 \ud615\ud0dc\uc758 \ud56d\uccb4\ub97c \ub9cc\ub4e4 \uc218 \uc788\ub2f5\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p>\uc6b0\ub9ac\u00a0\ubab8\uc18d\uc5d0\ub294\u00a0\uc218\ub9ce\uc740\u00a0B-\ub9bc\ud504\uad6c\uac00\u00a0\uc788\uace0,\u00a0\uc720\uc804\uc790 \uc7ac\uc870\ud569\uc5d0 \uc758\ud55c \ub3cc\uc5f0\ubcc0\uc774\ub85c \ubcc0\ud615\ub41c, \uadf8\ub798\uc11c B-\ub9bc\ud504\uad6c\ub9c8\ub2e4 \uac01\uac01\u00a0\ub3c5\ub9bd\uc801\uc778\u00a0\ud56d\uccb4\u00a0\uc720\uc804\uc790\ub97c\u00a0\uac00\uc9c0\uace0 \uc788\uc5b4\uc694.\u00a0\uadf8\ub798\uc11c, \ub9c8\uce58 \uc5f4\uc1e0\uc640 \uc790\ubb3c\uc1e0\uc758 \uad00\uacc4\ucc98\ub7fc, \uac10\uc5fc\uc73c\ub85c\u00a0\ubcd1\uc6d0\uccb4\uac00\u00a0\ub4e4\uc5b4\uc654\uc744\u00a0\ub54c \ubcd1\uc6d0\uccb4\u00a0\ud45c\uba74\uc758\u00a0\uc62c\ub85d\ubcfc\ub85d\ud55c\u00a0\ubd80\ubd84\uacfc\u00a0\ud37c\uc990\u00a0\uc870\uac01\ucc98\ub7fc\u00a0\ubaa8\uc591\uc774\u00a0\uc77c\uce58\ud558\ub294\u00a0\ud56d\uccb4\uac00\u00a0\ub9bc\ud504\uc808\uc5d0\u00a0\uc874\uc7ac\ud560\u00a0\ud655\ub960\uc774\u00a0\ub192\uc544\uc694.\u00a0\ubcd1\uc6d0\uccb4\uac00 \uc6b0\ub9ac \ubab8 \ub0b4\ubd80\ub85c \ub4e4\uc5b4\uc624\uba74\u00a0B-\ub9bc\ud504\uad6c\ub294\u00a0\ubcd1\uc6d0\uccb4\ub97c\u00a0\ubb3c\ub9ac\uce60\u00a0\ud56d\uccb4\ub97c\u00a0\uc870\ub9bd\ud560\u00a0\uc900\ube44\ub97c\u00a0\ud558\ub77c\ub294\u00a0\uc2e0\ud638\ub97c\u00a0\ubc1b\uc544\uc694.\u00a0\uadf8\ub9ac\uace0\u00a0\ubcd1\uc6d0\uccb4\uac00\u00a0\uc6b0\ub9ac\u00a0\ubab8\uc5d0\u00a0\uc704\ud5d8\ud558\ub2e4\ub294\u00a0\uc0ac\uc2e4\uc774\u00a0\ub2e4\ub978\u00a0\uba74\uc5ed\u00a0\uc138\ud3ec\uc5d0 \uc758\ud574\u00a0\ud655\uc778\ub418\uba74\u00a0B-\ub9bc\ud504\uad6c\ub294\u00a0\ubcd1\uc6d0\uccb4\u00a0\ud45c\uba74\uc5d0\u00a0\ub354\uc6b1\u00a0\uc798\u00a0\ub9de\ub3c4\ub85d\u00a0\ud56d\uccb4\uc758\u00a0\uad6c\uc870\ub97c \ubcc0\uacbd\ud574\uc11c\u00a0\ub9ce\uc740\u00a0\uc591\uc744\u00a0\uc0dd\uc0b0\ud55c\u00a0\ub4a4\u00a0\ud608\uad00,\u00a0\uce68\uc0d8,\u00a0\uc7a5\u00a0\ub4f1\uc73c\ub85c\u00a0\ubc29\ucd9c\ud55c\ub2f5\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p>\uc5b4\ub5a4\u00a0\ubcd1\uc6d0\uccb4\uac00\u00a0\uc6b0\ub9ac\u00a0\ubab8\uc5d0\u00a0\ub4e4\uc5b4\uc654\uc744\u00a0\ub54c\u00a0\ud56d\uccb4\uc640\u00a0\ubaa8\uc591\uc774\u00a0\ub531\u00a0\ub9de\uc73c\uba74\u00a0\ub2e4\ub978\u00a0\ud56d\uccb4\ub4e4\uc774\u00a0\uae08\uc138\u00a0\ubab0\ub824\uc640\u00a0\ud45c\uba74\uc5d0\u00a0\ub2ec\ub77c\ubd99\uc9c0\uc694.\u00a0\uadf8\ub9ac\uace0\u00a0\uba74\uc5ed\uccb4\uacc4\u00a0\uc138\ud3ec\ub4e4\uc740\u00a0\ub300\ubd80\ubd84\u00a0\ud56d\uccb4\uc758\u00a0\u2018\uc190\uc7a1\uc774\u2019\ub97c\u00a0\uc778\uc2dd\ud574\uc11c \u2018\uc7a1\uc744\u2019\u00a0\uc218\u00a0\uc788\uc5b4\uc11c\u00a0\ubcd1\uc6d0\uccb4\uc640\u00a0\ud56d\uccb4\ub97c\u00a0\uac19\uc774\u00a0\uc7a1\uc544\uba39\uac70\ub098\u00a0\ub3c5\uc18c\ub85c\u00a0\uac10\uc5fc\uc2dc\ucf1c\uc694.\u00a0\uac8c\ub2e4\uac00\u00a0\ube44\ub9cc \uc138\ud3ec\ub77c\ub294\u00a0\uac10\uc2dc\ubcd1\uc740\u00a0\ubbf8\ub9ac\u00a0\ud56d\uccb4\ub97c\u00a0\ubd99\uc7a1\uace0\u00a0\ud56d\uccb4\uc5d0\u00a0\ubcd1\uc6d0\uccb4\uac00\u00a0\ubd99\uc744 \ub54c\uae4c\uc9c0\u00a0\uae30\ub2e4\ub9b0\ub2f5\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" data-attachment-id=\"4703\" data-permalink=\"https:\/\/biochemistry.khu.ac.kr\/lab\/?attachment_id=4703\" data-orig-file=\"https:\/\/biochemistry.khu.ac.kr\/lab\/wp-content\/uploads\/2019\/10\/002.jpg\" data-orig-size=\"688,458\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"002\" data-image-description=\"\" data-image-caption=\"\" data-medium-file=\"https:\/\/biochemistry.khu.ac.kr\/lab\/wp-content\/uploads\/2019\/10\/002-300x200.jpg\" data-large-file=\"https:\/\/biochemistry.khu.ac.kr\/lab\/wp-content\/uploads\/2019\/10\/002.jpg\" class=\"aligncenter wp-image-4703 size-full\" src=\"http:\/\/163.180.4.222\/lab\/wp-content\/uploads\/2019\/10\/002.jpg\" alt=\"\" width=\"688\" height=\"458\" srcset=\"https:\/\/biochemistry.khu.ac.kr\/lab\/wp-content\/uploads\/2019\/10\/002.jpg 688w, https:\/\/biochemistry.khu.ac.kr\/lab\/wp-content\/uploads\/2019\/10\/002-300x200.jpg 300w\" sizes=\"auto, (max-width: 688px) 100vw, 688px\" \/><\/p>\n<p style=\"text-align: center;\">\uc54c\ub808\ub974\uae30\ub97c \uc798 \uc77c\uc73c\ud0a4\ub294 \uc2dd\ud488\ub4e4. \ub545\ucf69 \ub4f1\uc758 \uacac\uacfc\ub958\ub098 \uafc0\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \uac74\uac15\uc5d0 \uc88b\uc9c0\ub9cc, \ub204\uad70\uac00\uc5d0\uac8c\ub294 \uc0dd\uba85\uc744 \uc704\ud611\ud558\ub294 &#8216;\ub3c5&#8217;\uc774 \ub420 \uc218\ub3c4 \uc788\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\ube44\ub9cc \uc138\ud3ec\ub294\u00a0\uac00\ub824\uc6c0\uc774\ub098\u00a0\ubd80\uc5b4\uc624\ub984,\u00a0\ubc1c\uc9c4\uacfc\u00a0\uac19\uc740\u00a0\uc54c\ub808\ub974\uae30\uc758 \uc8fc\uc694\u00a0\uc99d\uc0c1\uc758\u00a0\uc6d0\uc778\uc774\uc5d0\uc694.\u00a0\ud56d\uccb4\uac00\u00a0\ubd99\uc5b4\uc788\ub294\u00a0\ube44\ub9cc \uc138\ud3ec\uc758\u00a0\ud45c\uba74\uc5d0 \ubcd1\uc6d0\uccb4\uac00\u00a0\ubd99\uc73c\uba74\u00a0\ube44\ub9cc \uc138\ud3ec\ub294\u00a0\uac00\ub2a5\ud55c\u00a0\uadf8\u00a0\ubd80\ubd84\uc744\u00a0\ub2e4\ub978\u00a0\uc870\uc9c1\uc5d0\uc11c \uace0\ub9bd\uc2dc\ud0a4\uace0\u00a0\ud608\uad00\uc744\u00a0\ub9c9\uc73c\uba74\uc11c\u00a0\ub2e4\ub978\u00a0\uba74\uc5ed\uc138\ud3ec\ub4e4\uc744\u00a0\uac00\ub2a5\ud55c\u00a0\ub9ce\uc774 \ub04c\uc5b4\ub4e4\uc774\uae30\u00a0\ub54c\ubb38\uc5d0\u00a0\ubd80\uc885\uc774\u00a0\ubc1c\uc0dd\ud574\uc694.\u00a0\uadf8\ub9ac\uace0\u00a0\ubab0\ub824\ub4e0\u00a0\ubaa8\ub4e0\u00a0\uba74\uc5ed \uc138\ud3ec\ub294\u00a0\uac00\ub824\uc6c0\uc744\u00a0\uc720\ubc1c\ud558\ub294\u00a0\ubb3c\uc9c8\uc744\u00a0\ubd84\ube44\ud558\uc9c0\uc694.<\/p>\n<p>&nbsp;<\/p>\n<p>B-\ub9bc\ud504\uad6c\ub294\u00a0\uce68\ubc94\ud55c\u00a0\ubbf8\uc0dd\ubb3c\uc774\ub098\u00a0\ubb3c\uc9c8\uc744\u00a0\u2018\ud37c\uc990\u2019\ub85c\u00a0\uac00\ub450\ub294\u00a0\ud56d\uccb4\ub97c\u00a0\uc0dd\uc0b0\ud558\uae30\u00a0\uc804\uc5d0\u00a0\ub610\u00a0\ub2e4\ub978\u00a0\uacbd\ub85c\ub85c\u00a0\uc774\u00a0\u2018\uc2e0\ucc38\u2019\uc774\u00a0\uc815\ub9d0\u00a0\uc704\ud5d8\ud558\ub2e4\ub294\u00a0\ud655\uc778\uc744\u00a0\ubc1b\uc544\uc57c\ub9cc\u00a0\ud55c\ub2f5\ub2c8\ub2e4.\u00a0\ud56d\uccb4\uac00\u00a0\uc6b0\ub9ac\u00a0\ubab8\uc5d0\u00a0\uc720\uc775\ud55c\u00a0\ubb3c\uc9c8\uc744\u00a0\uacf5\uaca9\ud560\u00a0\uac00\ub2a5\uc131\uc744\u00a0\ucd5c\uc18c\ud55c\uc73c\ub85c\u00a0\ub9cc\ub4e4 \uc608\ubc29\ucc45\uc774\u00a0\ud544\uc694\ud558\ub2c8\uae4c\uc694.<\/p>\n<p>&nbsp;<\/p>\n<p>\ud56d\uccb4\uac00\u00a0\uc5b4\ub5a4\u00a0\ubb3c\uc9c8\uc758\u00a0\ud45c\uba74\uc744\u00a0\ubd99\uc7a1\uc744\u00a0\ub54c\u00a0\uc6b0\ub9ac\u00a0\ubab8\uc5d0\u00a0\ud574\uac00\u00a0\uc788\ub294\uc9c0 \ub610\ub294 \uc5c6\ub294\uc9c0\u00a0\uacb0\uc815\ud558\ub294\u00a0\uc138\ud3ec\ub294\u00a0\ubcf4\uc870\u00a0T\u00a0\uc138\ud3ec(help T cells, \uc5ec\uae30\uc11c T\ub294 thymus\uc5d0\uc11c \uc720\ub798)\uc608\uc694.\u00a0T-\ub9bc\ud504\uad6c\ub77c\uace0\ub3c4\u00a0\ubd88\ub9ac\ub294 \ubcf4\uc870\u00a0T\u00a0\uc138\ud3ec\uc758\u00a0\uc8fc\uc694\u00a0\uc784\ubb34\ub294\u00a0\ubcd1\uc6d0\uade0\u00a0\uac10\uc5fc\uc73c\ub85c\u00a0\ubc1c\uc0dd\ud55c\u00a0\uc190\uc0c1\uc744\u00a0\ubd84\uc11d\ud558\uace0\u00a0\uadf8\uc5d0\u00a0\ub530\ub978\u00a0\uac00\uc7a5\u00a0\ud6a8\uacfc\uc801\uc778\u00a0\ubc18\uc751\uc744\u00a0\uc120\ud0dd\ud558\ub294\u00a0\uac70\uc9c0\uc694.\u00a0B-\ub9bc\ud504\uad6c\uc640\u00a0\ud568\uaed8\u00a0\uc6b0\ub9ac\u00a0\ubab8\uc758\u00a0\uba74\uc5ed\uccb4\uacc4\ub97c\u00a0\ucc45\uc784\uc9c0\ub294\u00a0\ub4e0\ub4e0\ud55c\u00a0\u2018\uc544\uad70\u2019\uc774\uc5d0\uc694.\u00a0\ubcf4\ud1b5\uc740\uc694.<\/p>\n<p>&nbsp;<\/p>\n<p>\ub9cc\uc57d\u00a0\uc6b0\ub9ac\u00a0\ubab8\uc5d0\u00a0\ub4e4\uc5b4\uc628\u00a0\ubb3c\uc9c8\uc774\u00a0\uc870\uc9c1\uc5d0\u00a0\uc190\uc0c1\uc744\u00a0\uc8fc\uc9c0\u00a0\uc54a\uc73c\uba74\u00a0\ubcf4\uc870\u00a0T\u00a0\uc138\ud3ec\ub294\u00a0\ud65c\uc131\ud654\ub418\uc9c0\u00a0\uc54a\uc544\uc694.\u00a0\uadf8\ub7f0\ub370\u00a0\uc54c\ub808\ub974\uae30\u00a0\ubc18\uc751\uc5d0\uc11c\ub294 \ubcf4\uc870\u00a0T\u00a0\uc138\ud3ec\uac00\u00a0\uc800\uc808\ub85c\u00a0\ud65c\uc131\ud654\ub418\uc5b4\u00a0\ud56d\uccb4\u00a0\uc0dd\uc0b0\uc744\u00a0\uac00\uc18d\ud654\ud55c\ub2f5\ub2c8\ub2e4.\u00a0\uc65c\u00a0\uc774\ub7f0\u00a0\ud604\uc0c1\uc774\u00a0\uc77c\uc5b4\ub098\ub294\uc9c0\ub294\u00a0\uc544\uc9c1\u00a0\uba85\ud655\ud558\uac8c \uc774\ud574\ub418\uc9c0\ub294 \uc54a\uc558\uc9c0\ub9cc,\u00a0\uacb0\uacfc\ub294\u00a0\ubd84\uba85\ud558\uc9c0\uc694.\u00a0\uc774\ub807\uac8c\u00a0\ub108\ubb34 \ub9ce\uc740 \ud56d\uccb4\ub97c\u00a0\ubd84\ube44\uc2dc\ud0b4\uc73c\ub85c\uc368\u00a0\uba74\uc5ed\uccb4\uacc4\uac00\u00a0\uc798\ubabb\u00a0\ubc18\uc751\ud558\uac8c\u00a0\ub9cc\ub4dc\ub294\u00a0\ubb3c\uc9c8\uc744\u00a0\u2018\uc54c\ub808\ub974\uae30\u00a0\ud56d\uc6d0\u2019\uc774\ub77c\uace0\u00a0\ubd88\ub7ec\uc694.\u00a0\ub3d9\ubb3c\uc758\u00a0\ud138\uc774\ub098\u00a0\uba3c\uc9c0,\u00a0\uc2dd\ud488\u00a0\uc131\ubd84\u00a0\ub4f1\u00a0\uc544\uc8fc\u00a0\ub9ce\uc740\u00a0\uc694\uc18c\uac00\u00a0\uc54c\ub808\ub974\uae30\u00a0\ud56d\uc6d0\uc774\u00a0\ub420\u00a0\uc218\u00a0\uc788\ub2f5\ub2c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\">\uc790 \uc774\uc5d0 \uc138\uade0\uc131 \ubc0f \ubc14\uc774\ub7ec\uc2a4\uc131 \uc9c8\ubcd1\uacfc \ud56d\uccb4\uc5d0 \ub300\ud55c \uc6b0\ub9ac\uc758 \uacfc\ud559\uc801\uc778 \uc774\ud574\uac00 \uc5b4\ub5bb\uac8c \ubc1c\uc804\ud574 \uc654\ub294\uc9c0 \uc0b4\ud3b4\ubcfc\uae4c\uc694?<\/p>\n<p>&nbsp;<\/p>\n<p style=\"text-align: left;\">\ud604\ubbf8\uacbd\uc774 16\uc138\uae30 \ub9d0\uc5d0 \ub124\ub35c\ub780\ub4dc\uc5d0\uc11c \ubc1c\uba85\ub418\uae30 \uc804\uae4c\uc9c0, \uc721\uc548\uc73c\ub85c\ub294 \ubcfc \uc218 \uc5c6\ub294 \ubbf8\uc18c \uc0dd\uba85\uccb4\ub4e4\uc740 \uc0ac\uc0c9\uacfc \uc0c1\uc0c1\uc758 \uc601\uc5ed \uc18d\uc5d0\uc11c\ub9cc \uc874\uc7ac\ud588\ub2f5\ub2c8\ub2e4. \uadf8\ub7ec\ub358 \uc911, \ub124\ub35c\ub780\ub4dc\uc778\uc778 \ub808\uc6b0\ubca4\ud6c4\ud06c(1632-1723)\ub294 \ud604\ubbf8\uacbd\uc73c\ub85c \uc0dd\ubb3c\uc744 \uc5f0\uad6c\ud558\ub294 \ubbf8\ub798\uc758 \uacfc\ud559\uc790\ub4e4\uc5d0\uac8c \uc5c4\uccad\ub09c \uc601\ud5a5\uc744 \ubbf8\ucce4\uc5b4\uc694. \ub808\uc6b0\ubca4\ud6c4\ud06c\ub294 \ud3ec\ubaa9\uc0c1\uc73c\ub85c \ub098\uc911\uc5d0 \ub378\ud504\ud2b8\uc758 \uc9c0\ubc29 \uc815\ubd80 \uad00\ub9ac\uac00 \ub418\uc5c8\ub294\ub370, \uadf8\uc758 \uc8fc\ub41c \ucde8\ubbf8\ub294 \ub80c\uc988\ub97c \ub9cc\ub4dc\ub294 \uac83\uacfc \uadf8\uc758 \ub80c\uc988\ub85c \ub9cc\ub4e0 \ud655\ub300\uacbd\uc73c\ub85c \uadf8\uac00 \uc5bb\uc744 \uc218 \uc788\ub294 \ubb3c\uac74\uc774\uba74 \ubb34\uc5c7\uc774\ub4e0\uc9c0 \uc0b4\ud3b4\ubcf4\ub294 \uac83\uc774\uc5c8\uc5b4\uc694. \uadf8\uc758 \ub80c\uc988\ub4e4\uc740 \uc720\ub7fd\uc5d0\uc11c \uac00\uc7a5 \uc6b0\uc218\ud55c \uac83\uc774\uc5c8\ub294\ub370, 1673\ub144\uc744 \uc2dc\uc791\uc73c\ub85c \ub808\uc6b0\ubca4\ud6c4\ud06c\ub294 \uadf8\uc758 \ud604\ubbf8\uacbd\uc73c\ub85c 10\ub144 \uc774\uc0c1\uc5d0 \uac78\uccd0 \uc218\ucc9c \uc885\uc758 \ubb3c\uc9c8\uc744 \uc5f0\uad6c\ud588\uc5b4\uc694. \uadf8\ub294 \ub9ce\uc740 \ub2e4\ub978 \ubbf8\uc0dd\ubb3c \uc885\ub4e4\ub85c \uc774\ub8e8\uc5b4\uc9c4, \uc644\uc804\ud788 \uc0c8\ub85c\uc6b4 \ubbf8\uc18c \uc720\uae30\uccb4\uc758 \uc138\uacc4\ub97c \ubc1c\uacac\ud588\ub2f5\ub2c8\ub2e4.<\/p>\n<p style=\"text-align: left;\">\ub808\uc6b0\ubca4\ud6c4\ud06c\ub294 \uc815\uae30\uc801\uc73c\ub85c \uadf8\uac00 \uad00\ucc30\ud55c \uc0ac\ud56d\ub4e4\uc744 \ub7f0\ub358\uc758 \uc655\ub9bd\ud559\ud68c\uc5d0 \uc54c\ub838\uace0 \uc655\ub9bd\ud559\ud68c\ub294 \uadf8\uac83\ub4e4\uc744 \ucd9c\ud310\ud588\uc5b4\uc694. \uadf8\ub294 \uc790\uc2e0\uc774 \ubc1c\uacac\ud55c \uac83\uc744 \uc9c0\ub098\uce60 \uc815\ub3c4\ub85c \uc138\uc2ec\ud558\uac8c \uae30\ub85d\ud588\ub294\ub370, \uc608\ub97c \ub4e4\uba74, \ud55c \ubcf4\uace0\uc11c\uc5d0\uc11c \uadf8\ub294 \uc790\uc2e0\uc758 \uce58\uc544 \uc0ac\uc774\uc5d0\uc11c \ucc44\ucde8\ud55c \ubb3c\uc9c8\uc758 \uc678\uc591\uc744 \uae30\uc220\ud558\uba74\uc11c\u00a0 &#8220;\ub098\uc758 \uce58\uc544\ub294 \ud56d\uc0c1 \ub9e4\uc6b0 \uae68\ub057\ud558\uac8c \uc720\uc9c0\ub418\uc9c0\ub9cc \uadf8\ub7fc\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \ub098\ub294 \uadf8\uac83\uc744 \ud604\ubbf8\uacbd\uc73c\ub85c \uad00\ucc30 \ud560 \ub54c, \uadf8\uac83\ub4e4 \uc0ac\uc774\uc5d0 \uc57d\uac04 \ud558\uc580 \ubb3c\uc9c8\uc774 \uc790\ub77c\uace0 \uc788\ub294 \uac83\uc744 \ubc1c\uacac\ud588\ub2e4. \uc774 \ubb3c\uc9c8\uc5d0\ub294 \uc544\ub9c8\ub3c4 \uc0dd\ubb3c\uccb4\uac00 \uc788\uc73c\ub9ac\ub77c\uace0 \ub098\ub294 \ud310\ub2e8\ud588\ub2e4.&#8221;\ub77c\uace0 \uc37c\uc5b4\uc694. \uc790\uae30 \uc790\uc2e0\uc758 \ud504\ub77c\uadf8\uc5d0\uc11c \uadf8\ub294 &#8216;\uc544\uc8fc \ud65c\ubc1c\ud558\uac8c \uc6c0\uc9c1\uc774\ub294 \ub9e4\uc6b0 \uc791\uc740 \ub9ce\uc740 \ub3d9\ubb3c\uccb4&#8217;\ub97c \ubc1c\uacac\ud588\ub2e4\ub294 \uac83\uc778\ub370, \uadf8\uac83\ub4e4\uc740 \ubb3c \uc18d\uc5d0\uc11c \ub9e4\uc6b0 \ube68\ub9ac \uc774\ub3d9\ud588\uc5b4\uc694. \ub808\uc6b0\ubca4\ud6c4\ud06c\uc758 \ubcf4\uace0 \uc774\ud6c4\uc5d0 \ud604\ubbf8\uacbd\uc73c\ub85c \uc774 \uc720\uae30\uccb4\ub4e4\uc744 \ub2e4\uc2dc \uc0b4\ud540 \uc0ac\ub78c \uc911\uc5d0 \uc544\ubb34\ub3c4 \uadf8\uac83\ub4e4\uc774 \uc0b4\uc544\uc788\uc74c\uc744 \uc758\uc2ec\ud558\uc9c0 \uc54a\uc558\uace0, \ub808\uc6b0\ubca4\ud6c4\ud06c\uc758 \uad00\ucc30 \uacb0\uacfc\ub4e4\uc740 \ub9ce\uc740 \uacfc\ud559\uc790\ub4e4\uc5d0 \uc758\ud574 \ud655\uc99d\ub418\uace0 \ud655\uc7a5\ub418\uc5c8\uc5b4\uc694. \uc644\uc804\ud788 \uc0c8\ub85c\uc6b4 \uc774 \ubbf8\uc0dd\ubb3c\uc758 \uc138\uacc4\ub294 \uc8fc\ub85c \ub808\uc6b0\ubca4\ud6c4\ud06c\uc758 \ucde8\ubbf8\ud65c\ub3d9\uc744 \ud1b5\ud574 \uc138\uacc4\uc5d0 \uc54c\ub824\uc84c\ub358 \uac83\uc774\uc8e0.<\/p>\n<p style=\"text-align: left;\">19\uc138\uae30 \uc911\uc5fd\uc5d0\ub294 \ub354 \uc88b\uc740 \ud604\ubbf8\uacbd\uc774 \ub9cc\ub4e4\uc5b4\uc84c\uace0 \uc0b4\uc544 \uc788\ub294 \ubbf8\uc18c \uc720\uae30\uccb4\uc758 \uc874\uc7ac\uac00 \ucda9\ubd84\ud788 \ud655\ub9bd\ub418\uc5c8\ub2f5\ub2c8\ub2e4. \uadf8\ub807\uc9c0\ub9cc \ub2f9\uc2dc\uc758 \uacfc\ud559\uc790\ub4e4 \uc911\uc5d0\uc11c \ubbf8\uc0dd\ubb3c\uc774 \uc9c8\ubcd1\uc758 \uc6d0\uc778\uc774 \ub41c\ub2e4\ub294 \uac83\uc744 \ubbff\ub294 \uc0ac\ub78c\uc740 \uac70\uc758 \uc5c6\uc5c8\uc5b4\uc694. \uc544\ub9c8\ub3c4 \ud07c\uc9c1\ud55c \uc778\uac04\uc5d0 \ub3c4\uc804\ud558\ub294, \ub208\uc5d0 \ubcf4\uc774\uc9c0 \uc54a\ub294 \uc791\uc740 \uc720\uae30\uccb4\uc5d0 \ub300\ud55c \uac1c\ub150\uc740 \ub300\ub2e4\uc218\uc758 \uc0ac\ub78c\ub4e4\uc774 \ubbff\uae30\uc5d0\ub294 \ub108\ubb34 \uc5b5\uc9c0 \uac19\uc544\uc11c \uc77c\uc9c0\ub3c4 \ubaa8\ub974\uc8e0.<\/p>\n<p style=\"text-align: left;\">\uc721\uc548\uc73c\ub85c \ubcf4\uae30\uc5d0\ub294 \ub108\ubb34 \uc791\uc740 \uc0dd\uba85\uccb4\uc758 \uc874\uc7ac\ub97c \uacfc\ud559\uc790\ub4e4\uc774 \ubc1b\uc544\ub4e4\uc774\uc790 \uadf8\ub4e4\uc740 \uc774 \ubbf8\uc0dd\ubb3c\ub4e4\uc774 \ubc1c\ud6a8\ucc98\ub7fc \ub2f9\uc2dc\uc5d0\ub294 \uc798 \uc54c\ub824\uc838 \uc788\uc9c0\ub9cc \uac70\uc758 \uc774\ud574\uac00 \uc548\ub418\ub294 \uacfc\uc815\uc5d0 \uad00\uc5ec\ud558\ub294\uc9c0 \uc5ec\ubd80\ub97c \uad81\uae08\ud574 \ud558\uae30 \uc2dc\uc791\ud588\uc5b4\uc694. \uc124\ud0d5\uc5d0\uc11c \uc54c\ucf54\uc62c\uc744, \ud3ec\ub3c4\uc5d0\uc11c \ud3ec\ub3c4\uc8fc\ub97c, \ubc1c\ud6a8\ub41c \ubcf4\ub9ac\uc5d0\uc11c \ub9e5\uc8fc\ub97c \ub9cc\ub4dc\ub294\ub370 \ud6a8\ubaa8\uac00 \ud544\uc694\ud558\ub2e4\ub294 \uac83\uc740 \uc218\ubc31 \ub144 \uc804\uc5d0 \uc774\ubbf8 \uc54c\ub824\uc838 \uc788\uc5c8\ub294\ub370, \ub2f9\uc2dc\uc758 \uba87\uba87 \uacfc\ud559\uc790\ub4e4\uc740 &#8220;\ud6a8\ubaa8\uac00 \uc0b4\uc544\uc788\ub294 \ubbf8\uc18c \uc720\uae30\uccb4\uc77c \uc218 \uc788\uc744\uae4c?&#8221;\ub77c\ub294 \uc758\ubb38\uc744 \uac16\uae30 \uc2dc\uc791\ud588\ub2f5\ub2c8\ub2e4.<\/p>\n<p style=\"text-align: left;\">\uc5b8\uae09\ud55c \u2018\ubc1c\ud6a8\u2019\ub77c\ub294 \ud604\uc0c1\uc5d0 \ud544\uc218\uc801\uc778 \uac83\uc73c\ub85c \ubcf4\uc774\ub294 \ud6a8\ubaa8\uc640 \uac19\uc740 \uc791\uc740 \u2018\ubb3c\uc9c8\u2019\uc744 \ub2f9\uc2dc\uc5d0\ub294 &#8216;\ud6a8\uc18c&#8217;\ub77c\uace0 \ubd88\ub838\ub294\ub370(\ud604\uc7ac\ub294 \ud6a8\uc18c\uc758 \uc758\ubbf8\uac00 \ubc14\ub00c\uc5b4\uc11c, \uc138\ud3ec \ub0b4\uc5d0\uc11c \ud569\uc131\ub418\uc5b4 \uc18c\ud654\ub098 \ud638\ud761 \ub4f1, \uc0dd\uccb4 \ub0b4\uc5d0\uc11c \ud589\ud574\uc9c0\ub294 \uac70\uc758 \ubaa8\ub4e0 \ud654\ud559 \ubc18\uc751\uc758 \ub9e4\uccb4\uac00 \ub418\uc5b4 \u2018\ucd09\ub9e4\u2019 \uc5ed\ud560\uc744 \ud558\ub294 \ubaa8\ub4e0 \uace0\ubd84\uc790 \ud654\ud569\ubb3c\uc744 \ub73b\ud55c\ub2f5\ub2c8\ub2e4.), 19\uc138\uae30 \uc911\ubc18\uc5d0 \ud070 \ub17c\uc7c1 \uac70\ub9ac \uc911 \ud558\ub098\ub294 \uc774 \ud6a8\ubaa8\uac00 \uc0b4\uc544\uc788\ub294\uc9c0 \uc5ec\ubd80\uc600\uc5b4\uc694. \ud328\ub7ec\ub370\uc774(1791-1867)\uc758 \uc2a4\uc2b9\uc778 \ud5d8\ud504\ub9ac \ub370\uc774\ube44(1778-1829)\ub97c \ud3ec\ud568\ud574\uc11c 19\uc138\uae30 \ucd08\uc5d0 \ub9ce\uc740 \ub6f0\uc5b4\ub09c \ud654\ud559\uc790\ub4e4\uc740 \uc5b4\ub5a4 \ud654\ud559\ubc18\uc751\ub4e4\uc740 \uc5b4\ub5a4 \ubb3c\uc9c8\uc774 \uadf8 \ubc18\uc751 \uc911\uc5d0 \ucca8\uac00\ub418\uba74 \ubc18\uc751 \uc18d\ub3c4\uac00 \ud06c\uac8c \uc99d\uac00\ud558\uc9c0\ub9cc \uc774 \ucca8\uac00\ub41c \ubb3c\uc9c8\uc740 \ubc18\uc751 \uc911\uc5d0 \uc0ac\ub77c\uc9c0\uac70\ub098 \ubc18\uc751 \ud6c4\uc5d0 \uadf8 \uc0c1\ud0dc\uac00 \ubcc0\ud558\uc9c0 \uc54a\uc74c\uc744 \ubc1d\ud600\ub0c8\uc5b4\uc694. \uc608\ub97c \ub4e4\uba74, \ub179\ub9d0\uc740 \uadf8\uac83\uc5d0 \ud669\uc0b0\uc744 \uac00\ud558\uace0 \uac00\uc5f4\ud568\uc73c\ub85c\uc368 \ub2f9\uc73c\ub85c \ubcc0\ud658\ub420 \uc218 \uc788\uc5c8\uc9c0\ub9cc \ud669\uc0b0\uc774 \ube60\uc9c0\uba74 \ub179\ub9d0\uc740 \ub2f9\uc73c\ub85c \uc804\ud658\ub420 \uc218 \uc5c6\uc5c8\uc5b4\uc694. \uadf8\ub7ec\ub098 \ud669\uc0b0\uc740 \uc774 \ubc18\uc751 \ud6c4\uc5d0 \uc804\ud600 \ubcc0\ud558\uc9c0 \uc54a\uc558\uc5b4\uc694. \ub179\ub9d0\uc774 \ub2f9\uc73c\ub85c \uc804\ud658\ub41c \ud6c4\uc5d0\ub3c4 \uc804\ud658\uc774 \uc77c\uc5b4\ub098\uae30 \uc804\uacfc \ub611\uac19\uc740 \uc591\uc758 \ud669\uc0b0\uc774 \uc874\uc7ac\ud588\ub358 \uac83\uc774\uc8e0. \uac19\uc740 \uc2dd\uc73c\ub85c \ubc31\uae08 \uac00\ub8e8\ub294 \ubc18\uc751 \ub3d9\uc548 \uc790\uc2e0\uc740 \ubcc0\ud558\uc9c0 \uc54a\uc73c\uba74\uc11c\ub3c4 \uacfc\uc0b0\ud654\uc218\uc18c\ub97c \ubb3c\uacfc \uc0b0\uc18c\ub85c \ubd84\ud574\ud588\uc5b4\uc694. \uc774\ub7ec\ud55c \uc5f0\uad6c\uc5d0 \uc0ac\uc6a9\ub41c \ud669\uc0b0\uacfc \ubc31\uae08 \uadf8\ub9ac\uace0 \uc790\uc2e0\uc740 \ubcc0\ud558\uc9c0 \uc54a\uc73c\uba74\uc11c \ud654\ud559 \ubcc0\ud654\uc728\uc744 \uc99d\uac00\uc2dc\ud0a4\ub294 \ubb3c\uc9c8\uc744 \u2018\ucd09\ub9e4\u2019\ub77c\uace0 \ubd88\ub800\uc5b4\uc694.<\/p>\n<p style=\"text-align: left;\">\ud6a8\ubaa8\ub294 \uc54c\ucf54\uc62c \ubc1c\ud6a8 \uacfc\uc815 \uc911\uc5d0 \uc18c\ubaa8\ub418\uc9c0 \uc54a\uc9c0\ub9cc \ubc1c\ud6a8\uac00 \ud6a8\uacfc\uc801\uc73c\ub85c \uc77c\uc5b4\ub098\uae30 \uc704\ud574\uc11c \uc815\ub9d0\ub85c \ud544\uc694\ud55c \uac83 \uac19\uc558\uc5b4\uc694. \uadf8 \ub2f9\uc2dc\uc758 \ud654\ud559\uc790\ub4e4\uc740 \uc124\ud0d5\uc774 \uc54c\ucf54\uc62c\ub85c \uc804\ud658\ub418\ub294 \ub370 \ud6a8\ubaa8\uac00 \ub2e8\uc9c0 \ucd09\ub9e4\ub77c\uace0 \uc81c\uc548\ud588\uc5b4\uc694. \ud6a8\ubaa8\uc5d0 \ucd94\uac00\ud558\uc5ec \uba87 \uac00\uc9c0 \ub2e4\ub978 \ud6a8\uc18c\uac00 \uc54c\ub824\uc84c\ub294\ub370 \uadf8 \uc911\uc5d0 \ud3ec\ub3c4\uc8fc\ub97c \uc2dd\ucd08\ub85c \ubc14\uafb8\ub294 \ud6a8\uc18c\uac00 \uc788\uc5c8\uc5b4\uc694. \uc2a4\uc6e8\ub374\uc758 \ubca0\ub974\uc140\ub9ac\uc6b0\uc2a4(1779-1848)\uc5d0 \uc758\ud558\uba74, \uc774 \ud6a8\uc18c\ub4e4\uc740 \ubb34\uae30\uc801\uc774\uace0, \ubb34\uc0dd\ubb3c\uc801\uc778 \ucd09\ub9e4\uc5d0 \ubd88\uacfc\ud588\uc5b4\uc694. \ub610 \ud55c \uc0ac\ub78c\uc758 \ub6f0\uc5b4\ub09c \ud654\ud559\uc790\uc778 \ub3c5\uc77c\uc758 \ub9ac\ube44\ud788(1803-1873)\ub294 \ud6a8\ubaa8\uac00 \uc0b4\uc544\uc788\ub294 \uc791\uc740 \uc0dd\ubb3c\uc77c \uc218 \uc788\uc74c\uc744 \ubc1b\uc544\ub4e4\uc600\uc9c0\ub9cc \uc5ec\uc804\ud788 \uc54c\ucf54\uc62c \uc0dd\uc131\uc758 \uc6d0\uc778\uc774 \ub418\ub294 \ud6a8\uc18c\ub294 \uc8fd\uc740 \ub610\ub294 \uc8fd\uc5b4\uac00\ub294 \ud6a8\ubaa8 \uc720\uae30\uccb4\uac00 \ub0b4\ub193\uc740 \ubb34\uc0dd\ubb3c \ucd09\ub9e4\ub77c\uace0 \ubbff\uc5c8\uc5b4\uc694. \ud6a8\uc18c\uac00 \ubbf8\uc18c \uc720\uae30\uccb4\ub77c\ub294 \uc0dd\uac01\uc744 \uc77c\ubc18\uc801\uc778 \uc0ac\ub78c\ub4e4\uc774 \ubc1b\uc544\ub4e4\uc774\uae30\ub97c \uaebc\ub9b0 \uac83\uc740 \ubd80\ubd84\uc801\uc73c\ub85c \uadf8 \ub2f9\uc2dc\uc758 \ud654\ud559\uc790\ub4e4\uc758 \uacac\ud574\uc5d0\uc11c \uae30\uc778\ud588\uace0, \uadf8\ub798\uc11c \uad50\uacfc\uc11c\ub4e4\uc5d0\ub294 \ud6a8\uc18c\uac00 \ubb34\uc0dd\ubb3c \ucd09\ub9e4\ub77c\uace0 \uc801\ud600 \uc788\uc5c8\ub2f5\ub2c8\ub2e4.<\/p>\n<p style=\"text-align: left;\">\ud30c\uc2a4\ud1f4\ub974(1822-1895)\uac00 \ubc1c\ud6a8\ub97c \uc5f0\uad6c\ud558\uae30 \uc2dc\uc791\ud588\uc744 \ub54c, \ub2e4\uc591\ud55c \ubc1c\ud6a8\uac00 \uc54c\ub824\uc838 \uc788\uc5c8\uace0 \ub2e4\ub978 \uacfc\uc815\ub4e4, \uac00\ub839 \uc721\ub958 \ub4f1\uc758 \ubd80\ud328\ub294 \uc545\ucde8\ub098\ub294 \ucd5c\uc885 \uc0b0\ubb3c\uc744 \ub0b4\ub294 \ubc18\uc751\uc5d0 \uad00\uc5ec\ud558\ub294 \ud6a8\uc18c\ub4e4\uc5d0 \uae30\uc778\ud55c\ub2e4\uace0 \uc5ec\uae30\uc9c0\uae30 \uc2dc\uc791\ud588\ub294\ub370, \ud30c\uc2a4\ud1f4\ub974\ub294 \uc8fc\uc758\uae4a\uac8c \uc124\uacc4\ub418\uace0 \uaf3c\uaf3c\ud558\uac8c \uc218\ud589\ub41c \uc2e4\ud5d8\uc744 \ud1b5\ud574 \ud6a8\ubaa8\uc640 \ub2e4\ub978 \ud6a8\uc18c\ub4e4\uc774 \uc2e4\uc81c\ub85c\ub294 \ubbf8\uc0dd\ubb3c\uc784\uc744 \uc138\uc0c1\uc5d0 \uc54c\ub9b0 \uacfc\ud559\uc790\ub78d\ub2c8\ub2e4.<\/p>\n<p style=\"text-align: left;\">\ub8e8\uc774 \ud30c\uc2a4\ud1f4\ub974\ub294 1822\ub144\uc5d0 \ud504\ub791\uc2a4\uc758 \ub3cc\uc5d0\uc11c \ud0dc\uc5b4\ub098\uc11c \ud654\ud559\uc790\ub85c \ud6c8\ub828\ubc1b\uc558\uc5b4\uc694. \uadf8\uc758 \ucd08\uae30 \uc5f0\uad6c \uc911\uc5d0\ub294 \uadf8\uac00 \ubc1c\uacac\ud55c \ubd84\uc790 \ube44\ub300\uce6d\ud604\uc0c1\uc5d0 \ub300\ud55c \uc5f0\uad6c\uac00 \uc788\uc5c8\uc5b4\uc694. \uc5b4\ub5a4 \ubd84\uc790\ub294 \uc67c\ucabd \uc7a5\uac11\uacfc \uc624\ub978\ucabd \uc7a5\uac11\ucc98\ub7fc \ub450 \uac1c\uac00 \uac70\uc6b8\uc0c1 \ud615\ud0dc\ub85c \uc874\uc7ac\ud558\ub294\ub370, \uc885\uc885 \uc774\ub7ec\ud55c \ub450 \ud615\ud0dc\ub294 \ud654\ud559\uc801\uc73c\ub85c \uc2dd\ubcc4\uc774 \uc548\ub41c\ub2f5\ub2c8\ub2e4. \uadf8\ub7f0\ub370 \ub450 \uac1c\uc758 \uac70\uc6b8\uc0c1 \ud615\ud0dc\uc758 \ubb3c\uc9c8\uc740 \ud3b8\uad11\uc744 \ud68c\uc804\uc2dc\ud0a4\ub294 \uc131\uc9c8\uc774 \ub2ec\ub77c\uc11c, \ud55c \ud615\ud0dc\ub294 \ubc18\uc2dc\uacc4 \ubc29\ud5a5\uc73c\ub85c \uadf8\uac83\uc744 \ud68c\uc804\uc2dc\ud0a4\uace0 \ub610\ub2e4\ub978 \ud615\ud0dc\ub294 \uc2dc\uacc4\ubc29\ud5a5\uc73c\ub85c \ud68c\uc804\uc2dc\ud0a8\ub2f5\ub2c8\ub2e4. \ud30c\uc2a4\ud1f4\ub974\ub294 \ud0c0\ub974\ud0c0\ub974\uc0b0 \uacb0\uc815\uc774 \uac70\uc6b8\uc0c1 \ud615\ud0dc\ub85c \uc874\uc7ac\ud558\uba70 \ub450 \ud615\ud0dc\uac00 \ubc18\ub300 \ubc29\ud5a5\uc73c\ub85c \ud3b8\uad11\uc744 \ud68c\uc804\uc2dc\ud0b4\uc744 \ubc1c\uacac\ud588\uc5b4\uc694. \uadf8\ub294 \ub610\ud55c \ud0c0\ub974\ud0c0\ub974\uc0b0\uc758 \ud615\ud0dc \uc911 \ud558\ub098\ub9cc\uc774 \uc0dd\uba85\uccb4\uc5d0 \uc758\ud574 \ubb3c\uc9c8\ub300\uc0ac\ub420 \uc218 \uc788\uc74c\uc744 \uc785\uc99d\ud588\uc5b4\uc694. \ub2e4\ub978 \uac70\uc6b8\uc0c1 \ud0c0\ub974\ud0c0\ub974\uc0b0\uc740 \uc0dd\uba85\uccb4\uc5d0\uc11c \uc804\ud600 \uc0ac\uc6a9\ub418\uc9c0 \uc54a\ub294\ub2e4\ub294 \uac83\uc774\uc8e0. \uc0dd\uba85\uccb4\uac00 \ubd84\uc790\uc758 \uac70\uc6b8\uc0c1 \ud615\ud0dc\ub97c \uc2dd\ubcc4\ud560 \ub2a5\ub825\uc774 \uc788\uc74c\uc744 \ubc1c\uacac\ud55c \uac83\uc740 \uc0dd\ud654\ud559 \uccb4\uacc4\uc5d0 \ub300\ud55c \uc774\ud6c4\uc758 \uc774\ud574\uc5d0 \ud070 \uc601\ud5a5\uc744 \ubbf8\ucce4\uc5b4\uc694.<\/p>\n<p style=\"text-align: left;\">\ud30c\uc2a4\ud1f4\ub974\ub294 \ubc1c\ud6a8\uc5d0 \ub300\ud55c \uc2e4\ud5d8\uc744 \uc2dc\uc791\ud558\uae30 \uba87 \ub144 \uc804\ubd80\ud130 \ubc1c\ud6a8\uc758 \uacfc\uc815\uc5d0 \ub300\ud574 \uc5b4\ub290 \uc815\ub3c4\ub294 \uc54c\uace0 \uc788\uc5c8\uc5b4\uc694. \uadf8\uc758 \ud6a8\uc18c\uc5d0 \ub300\ud55c \uc9c0\uc801 \ud638\uae30\uc2ec\uc740 \uc5b4\ub5a4 \ud6a8\uc18c\uac00 \ud0c0\ub974\ud0c0\ub974\uc0b0\ucc98\ub7fc \uac70\uc6b8\uc0c1 \ubd84\uc790 \ud615\ud0dc\ub85c \uc874\uc7ac\ud560 \uc218 \uc788\ub294 \uc544\ubc00\uc54c\ucf54\uc62c\uc744 \ub9cc\ub4e4\uc5b4 \ub0b4\ub294 \uac83\uc744 \uc54c\uac8c \ub418\uc5c8\uc744 \ub54c \ube44\ub86f\ub418\uc5c8\ub294\ub370, \ud30c\uc2a4\ud1f4\ub974\uc5d0\uac8c \ud2b9\ud788 \ud765\ubbf8\uac00 \uc788\uc5c8\ub358 \uac83\uc740 \ubc1c\ud6a8 \uc911\uc5d0 \uc0dd\uc131\ub41c \uc544\ubc00\uc54c\ucf54\uc62c\uc774 \ub450 \uac00\uc9c0 \uac00\ub2a5\ud55c \ud615\ud0dc \uc911\uc5d0\uc11c \uc624\uc9c1 \ud55c \uac00\uc9c0 \ud615\ud0dc\ub9cc\uc73c\ub85c \uc874\uc7ac\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc774\uc5c8\uc5b4\uc694. \uadf8\ub294 \ubcf4\ud1b5\uc758 \ud654\ud559 \ubc18\uc751\uacfc\ub294 \ub2ec\ub9ac \uc0b4\uc544 \uc788\ub294 \uc138\ud3ec\ub9cc\uc774 \ud654\ud559\ubb3c\uc9c8\uc758 \uac70\uc6b8\uc0c1\ub4e4\uc744 \uc2dd\ubcc4\ud560 \uc218 \uc788\ub2e4\ub294 \uac83\uc744 \uc54c\uace0 \uc788\uc5c8\uae30 \ub54c\ubb38\uc5d0, \ud30c\uc2a4\ud1f4\ub974\ub294 \ucc98\uc74c\ubd80\ud130 \uc774 \uacb0\uacfc\uc758 \uc911\uc694\uc131\uc744 \uc778\uc2dd\ud588\uace0 \ubc1c\ud6a8\uac00 \uc0b4\uc544 \uc788\ub294 \uc720\uae30\uccb4\uc5d0\uc11c \uae30\uc778\ud55c\ub2e4\uace0 \ud655\uc2e0\ud55c \uac83\uc740 \ub2f9\uc5f0\ud558\ub2e4\uace0 \uc0dd\uac01\ud560 \uc218 \uc788\uc5b4\uc694. \uadf8\uc758 \ud6a8\uc18c\uc5d0 \ub300\ud55c \uc5f0\uad6c\uac00 \uc9c4\ud589\ub418\ub294 \ub3d9\uc548, \uadf8 \ub2f9\uc2dc\uc758 \uacfc\ud559\uc790\ub4e4\uc774 \ubc1b\uc544\ub4e4\uc774\uae30\ub97c \uac70\ubd80\ud568\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0, \ud30c\uc2a4\ud1f4\ub974\ub294 \ud6a8\uc18c\uac00 \uc0b4\uc544\uc788\ub294 \uc720\uae30\uccb4\uc5d0\uc11c \uae30\uc778\ud55c\ub2e4\uace0 \ubbff\uc5c8\uc5b4\uc694.<\/p>\n<p style=\"text-align: left;\">\ud30c\uc2a4\ud1f4\ub974\uc758 \ubc1c\ud6a8\uc5d0 \ub300\ud55c \uc2e4\ud5d8\uc740 \uadf8\uac00 \uad50\uc218\uac00 \ub41c\uc9c0 1\ub144 \ud6c4\uc778 1855\ub144\uc5d0 \uc9c4\uc9c0\ud558\uac8c \uc2dc\uc791\ub418\uc5c8\uc5b4\uc694. \ud55c \ud559\uc0dd\uc758 \uc544\ubc84\uc9c0\uac00 \ud6a8\ubaa8\ub97c \uc0ac\uc6a9\ud574 \uc0ac\ud0d5\ubb34\ub97c \uc54c\ucf54\uc62c\ub85c \ubc1c\ud6a8\uc2dc\ud0a4\ub294 \uc99d\ub958\uc8fc \uc81c\uc870\uc7a5\uc744 \uc18c\uc720\ud558\uace0 \uc788\uc5c8\ub294\ub370, \uadf8 \uacfc\uc815\uc5d0 \ubb38\uc81c\uac00 \uc0dd\uacbc\uae30 \ub54c\ubb38\uc5d0, \uadf8 \uc544\ubc84\uc9c0\ub294 \uc870\uc5b8\uc744 \ub4e3\uae30 \uc704\ud574 \ud30c\uc2a4\ud1f4\ub974\ub97c \ucc3e\uc544\uc654\uace0 \ud30c\uc2a4\ud1f4\ub974\ub294 \uadf8\uac00 \ub3c4\uc6b8 \uc218 \uc788\ub294\uc9c0 \uc54c\uc544\ubcf4\uae30 \uc704\ud574 \ud6a8\ubaa8\ub97c \uc870\uc0ac\ud558\uae30\ub85c \ud588\uc5b4\uc694. \ud30c\uc2a4\ud1f4\ub974\uac00 \ud604\ubbf8\uacbd\uc73c\ub85c \ud6a8\ubaa8 \uc54c\uac31\uc774\ub97c \uad00\ucc30\ud558\uace0 \ubc1c\ud6a8 \uacfc\uc815\uc5d0\uc11c \uc190\uc0c1\uc744 \uc785\uc73c\uba74 \uadf8\uac83\ub4e4\uc758 \ubaa8\uc591\uc774 \uc5b4\ub5bb\uac8c \ubc14\ub00c\ub294\uc9c0 \uc54c\uc544\ucc28\ub838\uc744 \ub54c, \uadf8\ub294 \ud6a8\ubaa8\uc5d0 \ub300\ud558\uc5ec \ud070 \uad00\uc2ec\uc744 \uac16\uac8c \ub418\uc5c8\uace0, \uadf8\ub294 \uae4a\uc774 \uc788\uac8c \ubc1c\ud6a8\ub97c \uc5f0\uad6c\ud558\uae30 \uc2dc\uc791\ud588\uc5b4\uc694.<\/p>\n<p style=\"text-align: left;\">\uadf8\ub9ac\uace0 \uba87 \ub144\ub3d9\uc548 \ud30c\uc2a4\ud1f4\ub974\ub294 \uc790\uc138\ud558\uace0\ub3c4 \uc8fc\uc758\uae4a\uac8c \ub2e4\uc591\ud55c \ud6a8\ubaa8\ub4e4\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub97c \uc218\ud589\ud558\uc600\ub294\ub370, \uac70\uae30\uc5d0\ub294 \uc54c\ucf54\uc62c, \uc816\uc0b0, \ud0c0\ub974\ud0c0\ub974\uc0b0, \ub099\uc0b0(butyric acid)\uc744 \ub9cc\ub4dc\ub294 \ud6a8\uc18c\ub4e4\uc774 \uc788\uc5c8\uc5b4\uc694. \uadf8\ub294 \uc6b0\uc720\ub97c \uc2dc\uac8c \ub9cc\ub4dc\ub294 \uc720\uc0b0 \ud6a8\uc18c\ub3c4 \ubc1c\uacac\ud588\ub2f5\ub2c8\ub2e4. \uadf8\uac83\uc740 \ud6a8\ubaa8 \uc54c\uac31\uc774\ubcf4\ub2e4 \ud6e8\uc52c \uc791\uc9c0\ub9cc \ubaa8\uc591\uc740 \uadf8\uc640 \ube44\uc2b7\ud55c \ubbf8\uc18c \uc785\uc790\ub85c \uc774\ub8e8\uc5b4\uc838 \uc788\uc5c8\uc5b4\uc694. \ud30c\uc2a4\ud1f4\ub974 \uc774\uc804\uc5d0\ub294 \uc544\ubb34\ub3c4 \uc2e0 \uc6b0\uc720\uc5d0\uc11c \ubbf8\uc18c \ubb3c\uc9c8\uc744 \ubcf4\uc9c0 \ubabb\ud588\ub294\ub370, \ud30c\uc2a4\ud1f4\ub974\ub294 \uc720\uc0b0 \ud6a8\uc18c\uc758 \uc791\uc740 \uc785\uc790\ub97c \ubc1c\uacac\ud560 \uc815\ub3c4\ub85c \uc8fc\uc758\uae4a\uace0 \uad00\ucc30\ub825\uc774 \ub6f0\uc5b4\ub0ac\uc5b4\uc694. \uadf8\ub294 \uc774 \uc785\uc790\ub4e4\uc744 \ubd84\ub9ac\ud574 \ub0c8\uace0 \uadf8\uac83\ub4e4\uc5d0 \uc758\ud574 \uc6b0\uc720\ub97c \uc2dc\uac8c \ud558\ub294 \uac83\uc774 \uac00\ub2a5\ud568\uc744 \uc785\uc99d\ud588\uc73c\uba70, \uadf8\uac83\ub4e4\uc774 \ub2e4\ub978 \uc810\uc5d0\uc11c\ub3c4 \ud6a8\ubaa8\uc640 \ub9e4\uc6b0 \uc720\uc0ac\ud558\uac8c \ud589\ub3d9\ud568\uc744 \ubc1c\uacac\ud588\uc5b4\uc694.<\/p>\n<p style=\"text-align: left;\">\uadf8\uac00 \uc601\uc591\uc561\uc744 \uc774\uc6a9\ud574\uc11c \ud6a8\uc18c\ub4e4\uc744 \ubc30\uc591\ud588\uc744 \ub54c \uadf8\ub294 \uadf8\uac83\ub4e4\uc774 \ube60\ub974\uac8c \ubc88\uc2dd\ud558\uace0 \uadf8 \uc790\uc190\ub4e4\uc740 \ubaa8\uccb4\ub97c \ub2ee\uc558\uc74c\uc744 \uc54c\uc544\ub0c8\uc5b4\uc694. \uadf8\ub294 \uadf8\ub4e4\uc758 \uc131\uc7a5\ub960\uc774 \ubc1c\ud6a8\uc758 \uc815\ub3c4\uc5d0 \ube44\ub840\ud568\ub3c4 \uc785\uc99d\ud588\uc73c\uba70, \uadf8\ub294 \ub610\ud55c \uc591\ud30c\uc999\uc774 \uba87 \uac00\uc9c0 \ud6a8\uc18c\ub97c \uc8fd\uc774\uc9c0\ub9cc \uc5b4\ub5a4 \uac83\ub4e4\uc740 \uc8fd\uc774\uc9c0 \ubabb\ud558\ub294 \uac83\uc744 \ubc1d\ud600\ub0c8\uc5b4\uc694. \uc774\uac83\uc774 \uc704\ub300\ud55c \uacfc\ud559\uc790\uc758 \ub208\uc5d0 \uc0b4\uade0 \ubc29\ubc95\uc758 \ud78c\ud2b8\uac00 \ub41c \uac83\uc740 \ub2f9\uc5f0\ud558\uaca0\uc8e0?\u00a0 \uc774 \uc0b4\uade0 \ubc29\ubc95\uc740 \ud30c\uc2a4\ud1f4\ub974 \uc5f0\uad6c\uc758 \uc0b0\ubb3c\uc774\uc5c8\uc73c\uba70 \ub098\uc911\uc5d0\ub294 \uc678\uacfc \uc218\uc220 \ubd84\uc57c\uc5d0\uc11c \ud601\uba85\uc744 \uc77c\uc73c\ucf30\uc5b4\uc694. \uadf8\ub807\uc9c0\ub9cc \uc774\ub7ec\ud55c \uc5f0\uad6c\ub4e4\ub9cc\uc73c\ub85c\ub294 \ud6a8\uc18c\uac00 \uc0b4\uc544 \uc788\ub2e4\ub294 \uac1c\ub150\uc740 \ud655\ub9bd\ub418\uc9c0 \ubabb\ud588\uc5b4\uc694. \uc608\ub97c \ub4e4\uc5b4, \ub9ac\ube44\ud788\ub294 \ud6a8\uc18c\uac00 \uc8fd\uc5b4\uac00\ub294 \ubbf8\uc0dd\ubb3c\uc774 \ub0b4\ub193\ub294 \uc0b4\uc544\uc788\uc9c0 \uc54a\uc740 \ubb3c\uc9c8\uc774\ub77c\uace0 \uc774\ubbf8 \uc81c\uc548\ud588\uc5c8\uae30 \ub54c\ubb38\uc774\uc5d0\uc694.<\/p>\n<p style=\"text-align: left;\">\uadf8\ub7ec\ub098 \ud30c\uc2a4\ud1f4\ub974\uac00 \uc774\ud6c4 \uacc4\uc18d\ud558\uc5ec \uc218\ud589\ud55c \uacb0\uc815\uc801\uc778 \uc2e4\ud5d8\ub4e4\uc744 \ud1b5\ud574\uc11c \ub300\ubd80\ubd84\uc758 \ud654\ud559\uc790\ub4e4\uc740 \ud6a8\uc18c\uac00 \ubc14\ub85c \ubbf8\uc0dd\ubb3c\uc774\ub77c\ub294 \uac83\uc744 \ud655\uc2e0\ud558\uac8c \ub41c\ub2f5\ub2c8\ub2e4. \ud30c\uc2a4\ud1f4\ub974\ub294 \uba3c\uc800 \ubc1c\ud6a8\uac00 \uc774\uc804\uc5d0 \uc0dd\uac01\ub41c \uac83\uacfc\ub294 \ub2ec\ub9ac \uadf8\ub807\uac8c \uac04\ub2e8\ud55c \ud604\uc0c1\uc774 \uc544\ub2d8\uc744 \ubcf4\uc5ec\uc8fc\uc5c8\uc5b4\uc694. \uc608\ub97c \ub4e4\uba74, \uadf8\uac00 \uc54c\ucf54\uc62c \ubc1c\ud6a8\uc758 \uc0dd\uc131\ubb3c\uc744 \uc870\uc0ac\ud588\uc744 \ub54c, \uadf8\ub294 \uc54c\ucf54\uc62c \uc678\uc5d0 \uae00\ub9ac\uc138\ub9b0, \uc219\uc2e0\uc0b0 \ub4f1 \uc54c\ucf54\uc62c\uacfc\ub294 \ub2e4\ub978 \ud654\ud559\ubb3c\uc9c8\uc744 \ubc1c\uacac\ud588\uc5b4\uc694. \ubca0\ub974\uc140\ub9ac\uc6b0\uc2a4\uc640 \uadf8\uc758 \ucd94\uc885\uc790\ub4e4\uc774 \uc8fc\uc7a5\ud55c \ub300\ub85c \uc54c\ucf54\uc62c \ubc1c\ud6a8\uac00 \ub2e8\uc21c\ud55c \ud654\ud559\ubc18\uc751\uc744 \ucd09\uc9c4\uc2dc\ud0a4\ub294 \ud654\ud559\uc801 \ucd09\ub9e4\uc5d0 \uae30\uc778\ud558\ub294 \uac83\uc774\ub77c\uace0 \ud55c\ub2e4\uba74 \uc124\ud0d5\uc774\ub098 \ud3ec\ub3c4\ub2f9\uc5d0\uc11c \ub2e8\uc21c\ud558\uac8c \uc0dd\uc131\ub420 \uc218 \uc5c6\ub294 \uc774\ub7f0 \ub9ce\uc740 \ud654\ud559 \ubb3c\uc9c8\ub4e4\uc774 \uc5b4\ub5bb\uac8c \uc0dd\uc131\ub420 \uc218 \uc788\ub294\uc9c0\uac00 \uc27d\uac8c \uc124\uba85\ub420 \uc218 \uc5c6\uc5c8\uc5b4\uc694. \ud30c\uc2a4\ud1f4\ub974\ub294 \ubc1c\ud6a8\ub97c \ud1b5\ud55c \uc0dd\uc131\ubb3c\uc758 \ubcf5\uc7a1\uc131\uc744 \uc0b4\uc544\uc788\ub294 \uc720\uae30\uccb4\uac00 \uc774 \ubc18\uc751\uc5d0 \ucc45\uc784\uc774 \uc788\ub2e4\ub294 \uc0dd\uac01\uacfc \uc5f0\uacb0\uc2dc\ucf30\uc5b4\uc694. \uadf8\ub294 \ub610\ud55c \ubc1c\ud6a8 \uc911\uc5d0 \uc0dd\uc131\ub41c \ub9ce\uc740 \ubd80\uc0b0\ubb3c\ub4e4\uc774 \ubd84\uc790 \ube44\ub300\uce6d\uc744 \ub098\ud0c0\ub0b4\uba70, \ub450 \uac00\uc9c0 \uac00\ub2a5\ud55c \uac70\uc6b8\uc0c1 \ud615\ud0dc \uc911\uc5d0\uc11c \uc624\uc9c1 \ud55c \uac00\uc9c0 \ud615\ud0dc\ub9cc\uc774 \uc874\uc7ac\ud568\uc744 \ubc1c\uacac\ud588\uc5b4\uc694. \uadf8\ub294 \uc774\uac83\uc744 \uc0dd\uba85\uccb4 \uac1c\uc785\uc758 \uc99d\uac70\ub85c \ubbff\uc5c8\ub2f5\ub2c8\ub2e4.<\/p>\n<p style=\"text-align: left;\">\ud30c\uc2a4\ud1f4\ub974\ub294 \uc124\ud0d5, \uc554\ubaa8\ub2c8\uc544, \ub2e8\uc21c \ubb34\uae30\uc5fc\uc73c\ub85c\ub9cc \ub9cc\ub4e0 \ubc30\uc591\uae30\uc5d0\uc11c \ud6a8\ubaa8\ub97c \uc790\ub77c\uac8c \ud588\uc744 \ub54c, \uc880\ub354 \uc911\uc694\ud55c \ud070 \uc131\uacfc\ub97c \uc5bb\uc744 \uc218 \uc788\uc5c8\uc5b4\uc694. \uc774\ub7f0 \uc870\uac74 \ud558\uc5d0\uc11c\ub294 \uc801\uc740 \uc218\uc758 \ud6a8\ubaa8 \uc54c\uac31\uc774\uac00 \ubc30\uac00\ud560 \uc218 \uc788\uc5c8\uace0, \uadf8\uac83\ub4e4\uc740 \uadf8 \uacfc\uc815\uc5d0\uc11c \ubc30\uc591\uae30\uc758 \uc131\ubd84\ub4e4\uc744 \ub2e4 \uc0ac\uc6a9\ud574 \ubc84\ub838\uc5b4\uc694. \uadf8\uac83\ub4e4\uc758 \uc131\uc7a5\ub960\uc740 \uc54c\ucf54\uc62c\uc758 \uc0dd\uc131\ub960\uacfc \ube44\ub840\ud588\ub294\ub370, \uc774\ub7ec\ud55c \ubc1c\ud6a8 \ud604\uc0c1\uc740 \ud655\uc2e4\ud788 \ud6a8\ubaa8\uc758 \ubd84\ud574\ub098 \uc8fd\uc74c\uc758 \uacb0\uacfc\uac00 \uc544\ub2c8\uc5c8\ub358 \uac83\uc774\uc8e0. \uc989, \ud6a8\ubaa8 \uc54c\uac31\uc774\ub4e4\uc758 \uc218\ub294 \uc0c1\ub2f9\ud788 \uc99d\uac00\ub418\uace0 \uc788\uc5c8\uace0 \uc54c\ucf54\uc62c \uc5ed\uc2dc \uc591\uc801\uc73c\ub85c \uc99d\uac00\ub418\uace0 \uc788\uc5c8\uc5b4\uc694. \ud6a8\ubaa8\ub294 \ubc30\uc591\uae30\uc5d0 \uc788\ub294 \ub2e8\uc21c\ud55c \ubb3c\uc9c8\ub4e4\uc744 \ud3ec\ud68d\ud558\uc5ec \uadf8 \ubb3c\uc9c8\ub4e4\uc744 \uc774\uc6a9\ud574\uc11c \ub2e8\ubc31\uc9c8\uacfc \ud6a8\ubaa8\uc758 \ub2e4\ub978 \uc131\ubd84\uc744 \ub9cc\ub4e4\uc9c0\ub9cc, \ubb34\uc0dd\ubb3c \ucd09\ub9e4\ub294 \ucd09\ub9e4 \uc791\uc6a9\uc744 \ud558\ub294 \ud654\ud559 \ubc18\uc751 \uacfc\uc815 \ub3d9\uc548 \uc218\uc758 \uc99d\uac00\uac00 \uc5c6\ub294 \uc0c1\ud0dc\ub85c \ubcc0\ud558\uc9c0 \uc54a\uace0 \ub0a8\uc544 \uc788\uc744 \ubfd0\uc774\uc5c8\uc5b4\uc694. \uc774\uc640 \uac19\uc740 \uc2e4\ud5d8 \uacb0\uacfc\ub4e4\uc740 \ud6a8\ubaa8 \uc54c\uac31\uc774\uac00 \uc0b4\uc544 \uc788\ub2e4\ub294 \uc0dd\uac01\uacfc \uc77c\uce58\ud588\uace0 \ud6a8\uc18c\uc758 \ubb34\uae30 \uc774\ub860\uc744 \uc8fc\uc7a5\ud558\ub294 \uacfc\ud559\uc790\ub4e4\uacfc \uc2ec\uac01\ud55c \ub17c\uc7c1\uc744 \ubd88\ub7ec\uc77c\uc73c\ucf30\ub2f5\ub2c8\ub2e4.<\/p>\n<p style=\"text-align: left;\">\uc5b8\uae09\ud588\ub358 \ubc14\uc640 \uac19\uc774, \ud30c\uc2a4\ud1f4\ub974\ub294 \ub099\uc0b0 \ud6a8\uc18c\ub3c4 \ubc1c\uacac\ud588\uc5b4\uc694. \uc774 \ud6a8\uc18c\ub294 \uc6c0\uc9c1\uc774\ub294 \ud55c \uc885\ub958\uc758 \ubbf8\uc0dd\ubb3c\ub85c \uc774\ub8e8\uc5b4\uc838 \uc788\uc5c8\ub294\ub370, \uadf8\uac83\uc740 \uafc8\ud2c0\ub300\uba70 \ubc30\uc591\uae30 \uc18d\uc5d0\uc11c \uc7ac\ube68\ub9ac \ud5e4\uc5c4\ucce4\uae30 \ub54c\ubb38\uc5d0 \uc758\uc2ec\uc758 \uc5ec\uc9c0\uc5c6\uc774 \uc0b4\uc544 \uc788\ub2e4\uace0 \ud310\ub2e8\ud560 \uc218 \uc788\uc5c8\uc5b4\uc694. \uadf8\uac83\uc758 \ub9ce\uc740 \ud2b9\uc9d5\ub4e4\uc740 \uadf8\uac00 \uc5f0\uad6c \uc911\uc5d0 \ubc1c\uacac\ud55c \ub2e4\ub978 \ud6a8\uc18c\ub97c \ud2b9\uc9d5 \uc9c0\uc6b0\ub294 \uac83\ub4e4\uacfc \uc720\uc0ac\ud588\uc5b4\uc694. \ud30c\uc2a4\ud1f4\ub974\ub294 \ub610\ud55c \ub099\uc0b0 \ud6a8\uc18c\ub294 \uc0b0\uc18c\uac00 \uc788\uc744 \ub54c\ubcf4\ub2e4 \uc5c6\uc744 \ub54c \ub354 \uc27d\uac8c \uc218\uac00 \uc99d\uac00\ud568\uc744 \ubc1c\uacac\ud588\ub294\ub370, \uc774\uac83\uc73c\ub85c \uadf8\ub294 \uc5b4\ub5a4 \uc720\uae30\uccb4\uac00 \uc0b0\uc18c\uc5c6\uc774 \ubc88\uc2dd\ud558\uace0 \uc655\uc131\ud788 \uc790\ub784 \uc218 \uc788\ub2e4\ub294 \uac83\uc744 \ubc1d\ud600\ub0b8 \ucd5c\ucd08\uc758 \uacfc\ud559\uc790\ub85c \uc778\uc815\ub41c\ub2f5\ub2c8\ub2e4.<\/p>\n<p style=\"text-align: left;\">\ud30c\uc2a4\ud1f4\ub974\uc758 \uc790\uc138\ud558\uace0\ub3c4 \ud6cc\ub96d\ud55c \ud6a8\uc18c \uc5f0\uad6c\ub97c \ud1b5\ud574 \ubc1c\ud6a8 \uacfc\uc815\uc744 \uc218\ud589\ud558\ub294 \ubbf8\uc0dd\ubb3c\uc758 \uc131\uc7a5\uc5d0 \uc694\uad6c\ub418\ub294 \uc601\uc591 \uc870\uac74\ub4e4\uc774 \uc815\ud655\ud558\uac8c \ud655\ub9bd\ub418\uc5c8\uc5b4\uc694. \ubc1c\ud6a8 \ubbf8\uc0dd\ubb3c\uc758 \uac01 \uc720\ud615\uc740 \uc790\uc2e0\ub9cc\uc774 \uc120\ud638\ud558\ub294 \ub3c5\ud2b9\ud55c \uc0b0\ub3c4, \uc131\uc7a5 \uc628\ub3c4, \uc601\uc591 \uc870\uac74\uc744 \uac16\uace0 \uc788\uc73c\uba70 \uac01\uac01\uc758 \ud6a8\uc18c\ub294 \uc790\uc2e0\uc758 \ud2b9\uc9d5\uc801 \uc0b0\ubb3c\uc744 \ub0b4\ub193\uc544\uc694. \uc774\ub7ec\ud55c \ud6a8\uc18c\uc5d0 \ub300\ud55c \ucca0\uc800\ud55c \uc5f0\uad6c\ub97c \ud1b5\ud574 \ub2e4\uc591\ud55c \ubc1c\ud6a8 \uacfc\uc815\uc5d0 \uc694\uad6c\ub418\ub294 \ucd5c\uc801 \uc870\uac74\uc758 \uac1c\ubc1c\ud560 \uc218 \uc788\uac8c \ub418\ub294 \ub4f1 \uc2dd\ucd08, \ud3ec\ub3c4\uc8fc \ubc0f \uc54c\ucf54\uc62c \uc0b0\uc5c5\uc5d0 \ub9e4\uc6b0 \uc911\uc694\ud55c \uc815\ubcf4\ub97c \uc81c\uacf5\ud560 \uc218 \uc788\uac8c \ub418\uc5c8\uc5b4\uc694. \uc77c\uc0c1\uc0dd\ud65c \uc18d\uc5d0\uc11c \ud30c\uc2a4\ud1f4\ub974\uc758 \uc774\ub984\uc740 \uc6b0\uc720, \ud3ec\ub3c4\uc8fc, \ub2e4\ub978 \uc74c\ub8cc\ub4e4\uacfc \uc74c\uc2dd\ubb3c\ub4e4 \uc548\uc5d0\uc11c \ubbf8\uc0dd\ubb3c\uc758 \uc131\uc7a5\uc744 \ub9c9\uae30\uc704\ud574 \uadf8\uac83\ub4e4\uc744 \uac00\uc5f4\ud558\ub294 \ubc29\ubc95\uc778 \uc800\uc628\uc0b4\uade0\ubc95\uc774\ub780 \uba85\uce6d \uc18d\uc5d0 \uc0b4\uc544\uc788\ub294\ub370, \ud30c\uc2a4\ud1f4\ub974\ub294 \uc774 \ubc29\ubc95\uc744 1850\ub144\ub300\uc5d0 \ud3ec\ub3c4\uc8fc \uc0b0\uc5c5\uc5d0 \uc751\uc6a9\ud588\uace0, \ud3ec\ub3c4\uc8fc\uc758 \uc138\uade0 \uac10\uc5fc\uc744 \uc904\uc774\uace0 \ub9db\uacfc \uc9c8\uc744 \uac1c\uc120\uc2dc\ud0a4\ub294 \ub370 \uc911\uc694\ud55c \uacf5\ud5cc\uc744 \ud588\uc5b4\uc694.<\/p>\n<p style=\"text-align: left;\">\ud55c\ud3b8, \ud2b9\ubcc4\ud55c \uc870\uac74\uc5d0\uc11c \ubc1c\ud6a8 \uacfc\uc815\uc774 \uc798\ubabb\ub418\ub294 &#8216;\ubcd1&#8217;\uc5d0 \uac78\ub9ac\uae30\ub3c4 \ud55c\ub2e4\ub294 \uac83\uc774 \ud655\uc2e4\ud574\uc84c\uc5b4\uc694. \ud30c\uc2a4\ud1f4\ub974\ub294 \uc774 \u2018\ubcd1\u2019\ub4e4\uc774 \ubc1c\ud6a8 \ubbf8\uc0dd\ubb3c\uc744 \uac10\uc5fc\uc2dc\ud0a4\ub294 \ub2e4\ub978 \ubbf8\uc18c \uc720\uae30\uccb4\uc758 \uc874\uc7ac\ub098 \ubc1c\ud6a8 \ubbf8\uc0dd\ubb3c\uc774 \uc798\ubabb\ub41c \ucd5c\uc885 \uc0b0\ubb3c\uc744 \ub0b4\ub193\uac8c \ud558\ub294 \ubd80\uc815\ud655\ud55c \uc131\uc7a5 \uc870\uac74\uc5d0 \uae30\uc778\ud568\uc744 \uc778\uc2dd\ud588\uc5b4\uc694. \uc774\ub7f0 \uc5f0\uad6c\ub97c \ud558\ub294 \ub3d9\uc548 \ud30c\uc2a4\ud1f4\ub974\uac00 \ubc1c\ud6a8 \ubbf8\uc0dd\ubb3c\uacfc \uc778\uac04\uc758 \uc9c8\ubcd1 \ubbf8\uc0dd\ubb3c \uc0ac\uc774\uc758 \uc5f0\uad00\uc131\uc744 \uae68\ub2eb\uae30 \uc2dc\uc791\ud588\uc74c\uc740 \uc758\uc2ec\uc758 \uc5ec\uc9c0\uac00 \uc5c6\ub294\ub370, \ud2b9\uc815 \uc720\ud615\uc758 \ubbf8\uc18c \uc720\uae30\uccb4\uac00 \ud2b9\uc815\ud55c \ubc1c\ud6a8\uc640 \ubd80\ud328\ub97c \uc218\ud589\ud560 \uc218 \uc788\ub2e4\uba74, \uadf8\ub9ac\uace0 \ub2e4\ub978 \ubbf8\uc0dd\ubb3c\uc774 \ubc1c\ud6a8 \uacfc\uc815\uc5d0\uc11c \ubcd1\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\ub2e4\uba74, \uc5b4\ub5a4 \ub3d9\ubb3c\uc758 \ubcd1\uc774 \ud2b9\uc815 \uc720\ud615\uc758 \uc138\uade0\uc758 \uac10\uc5fc\uc5d0 \uc758\ud574 \uc57c\uae30\ub420 \uc218\ub3c4 \uc788\uc9c0 \uc54a\uaca0\ub294\uac00\ub77c\ub294 \uc9c8\ubb38\uc744 \uc5b4\ub835\uc9c0 \uc54a\uac8c \ud560 \uc218 \uc788\uae30 \ub54c\ubb38\uc774\uc5d0\uc694.<\/p>\n<p style=\"text-align: left;\">\ud30c\uc2a4\ud1f4\ub974\ub294 \ud654\ud559\uc73c\ub85c\ubd80\ud130 \ubc1c\ud6a8\ub85c, \uadf8 \ub2e4\uc74c\uc5d0\ub294 \uc790\uc5f0\ubc1c\uc0dd \ubd80\uc815\uc5d0 \uad00\ud55c \uc5f0\uad6c\ub85c \uba4b\uc9c4 \uc131\uacf5\uc744 \uac70\ub450\uba70 \ub098\uc544\uac14\uc5b4\uc694. \uadf8 \ub2e4\uc74c\uc73c\ub85c \ubc1c\ud6a8\uc758 &#8216;\uc138\uade0\uc774\ub860&#8217;\uc744 \uc9c8\ubcd1\uc758 &#8216;\uc138\uade0\uc774\ub860&#8217;\uc5d0 \uc801\uc6a9\ud558\ub294 \uac83\uc774 \uadf8\uc5d0\uac8c\ub294 \ubd88\uac00\ud53c\ud55c \uc21c\uc11c\uc600\ub2e4\uace0 \ubcfc \uc218 \uc788\ub294\ub370, 1862\ub144\uc5d0 \uadf8\ub294 &#8220;\uc138\uade0 \uc5f0\uad6c\ub294 \ub3d9\ubb3c\uacfc \uc2dd\ubb3c\uc758 \ubcd1\uacfc \ub9ce\uc740 \uc5f0\uad00\uc744 \uac00\uc9c0\uace0 \uc788\uc5b4\uc11c \ubd80\ud328\uc131 \uc9c8\ubcd1\uacfc \uc804\uc5fc\ubcd1\uc758 \ud0d0\uad6c\uc5d0\uc11c \uccab \ub2e8\uacc4\uac00 \ub41c\ub2e4&#8221;\uace0 \uc37c\uc73c\uba70, \uadf8\ub85c\ubd80\ud130 14\ub144 \ud6c4\uc5d0 \ud0c4\uc800\ubcd1 \ubc15\ud14c\ub9ac\uc544\ub97c \uac00\uc9c0\uace0 \uc790\uc2e0\uc758 \uc2e4\ud5d8\uc744 \uc2dc\uc791\ud558\uc600\uace0 \uc138\uade0\uc774\ub860\uc744 \ud655\uc99d\ud588\uc5b4\uc694.<\/p>\n<p style=\"text-align: left;\">\uc804\uc5fc\ubcd1\uc758 \uc138\uade0\uc774\ub860\uc774 \ubc1b\uc544\ub4e4\uc5ec\uc9c0\uae30 \uc804\uc5d0, \ubcd1\uc758 \uc6d0\uc778\uc740 \uc624\ub79c \uc138\uc6d4 \ub3d9\uc548 \uc2e0\ube44\uc640 \uc624\ud574\uc5d0 \ubb3b\ud600 \uc788\uc5c8\uc5b4\uc694. \uc5b4\ub5a4 \uc0ac\ub78c\ub4e4\uc740 \ubcd1\uc774 \ud0c0\ub77d\uc774\ub098 \uc8c4\uc5d0 \ub300\ud55c \uc9d5\uacc4\ub85c \uc0dd\uac01\ud588\uace0, \ub610 \uc5b4\ub5a4 \uc0ac\ub78c\ub4e4\uc740 \ub545\uc758 &#8216;\ud798&#8217;\uc774\ub77c\ub294 \uac83\uc774 \uc788\uc5b4\uc11c \uc774 \ud798\uc774 \uc81c\uc5b4\ub418\uc9c0 \uc54a\uc744 \ub54c \ubcd1\uc5d0 \uac78\ub9ac\uace0 \ubcd1\uc774 \ud37c\uc9c4\ub2e4\uace0 \ubbff\uc5c8\uc5b4\uc694. \uadf8\ub9ac\uace0 \uc5b4\ub5a4 \uc0ac\ub78c\ub4e4\uc740 \ubcd1\uc774 &#8216;\ub098\uc05c \uacf5\uae30&#8217;, \uc989 &#8216;\ub3c5\uae30&#8217;\ub85c \uc0dd\uae34\ub2e4\uace0 \ubbff\uc5c8\ub294\ub370, \uc608\ub97c \ub4e4\uba74 \ub9d0\ub77c\ub9ac\uc544(&#8216;\ub9d0\ub77c\ub9ac\uc544&#8217;\ub77c\ub294 \ub2e8\uc5b4\ub294 \uc774\ud0c8\ub9ac\uc544\uc5b4\ub85c &#8216;\ub098\uc05c \uacf5\uae30&#8217;\ub97c \ub73b\ud55c\ub2f5\ub2c8\ub2e4.)\ub294 \ub2aa\uc5d0\uc11c \uc62c\ub77c\uc628 \ub3c5\uae30 \ub54c\ubb38\uc5d0 \uc0dd\uae34\ub2e4\uace0 \uc0dd\uac01\ud588\uc5b4\uc694. \uc0b4\uc544\uc788\ub294 \ubbf8\uc138\ud55c \uc720\uae30\uccb4\ub85c\ubd80\ud130 \uc804\uc5fc\ubcd1\uc774 \uc0dd\uae34\ub2e4\uace0 \uc0dd\uac01\ud55c \uc0ac\ub78c\uc740 \uac70\uc758 \uc5c6\uc5c8\uace0, \uadf8\ub807\uac8c \uc0dd\uac01\ud55c \uc0ac\ub78c\ub4e4\uc870\ucc28\ub3c4 \ucda9\ubd84\ud788 \uacb0\uc815\uc801\uc778 \uc2e4\ud5d8\uc801 \uc99d\uac70\ub97c \ub0b4\ub193\uc744 \uc218 \uc5c6\uc5c8\uc8e0.<\/p>\n<p style=\"text-align: left;\">1836\ub144\uc5d0 \uc774\ud0c8\ub9ac\uc544\uc758 \uacfc\ud559\uc790 \ubc14\uc2dc(1773-1856)\ub294 \ud55c \uc885\ub958\uc758 \uacf0\ud321\uc774\uac00 \uacac\uc9c1 \uc0b0\uc5c5\uc5d0 \ubb38\uc81c\ub97c \uc77c\uc73c\ud0a4\uace0 \uc788\uc5c8\ub358 \ub204\uc5d0\uc758 \ubcd1\uc778 \ubc31\uac15\ubcd1\uc758 \uc6d0\uc778\uc784\uc744 \uc785\uc99d\ud588\uc5b4\uc694. \ubc14\uc2dc\ub294 \ubc31\uac15\ubcd1\uc5d0 \uac78\ub9b0 \ub204\uc5d0\uc5d0 \uc0dd\uae34 \ud770 \ubc18\uc810\uc5d0\uc11c \ucc44\ucde8\ud55c \ubb3c\uc9c8\uc744 \uac74\uac15\ud55c \ub204\uc5d0\uc5d0 \uc8fc\uc785\ud588\uc744 \ub54c, \ub611\uac19\uc740 \ubcd1\uc774 \uc720\ubc1c\ub418\ub294 \uac83\uc744 \ubc1d\ud600\ub0c8\uc5b4\uc694. \uadf8\ub294 \uadf8 \uc804\uc5fc\uc131 \ubb3c\uc9c8\uc744 \ud604\ubbf8\uacbd\uc73c\ub85c \uad00\ucc30\ud588\uc744 \ub54c \uadf8\uac83\uc5d0 \uacf0\ud321\uc774\uac00 \uc788\ub294 \uac83\uc744 \ubc1c\uacac\ud588\uace0, \uc0ac\ub78c\uc758 \uc9c8\ubcd1\uc778 \uc544\uad6c\ucc3d \uac19\uc740 \uc9c8\ubcd1\ub3c4 \uacf0\ud321\uc774 \ub54c\ubb38\uc5d0 \uc0dd\uae30\ub294 \uac83\uc774 \uace7 \ud655\uc2e4\ud574\uc84c\uc5b4\uc694.<\/p>\n<p style=\"text-align: left;\">\ub204\uc5d0\uc758 \ubcd1\uc740 \ud30c\uc2a4\ud1f4\ub974\uc5d0\uac8c \uc2e4\ud5d8\uc801 \uc218\uc900\uc5d0\uc11c \uc804\uc5fc\ubcd1\uacfc \uc9c1\uc811 \uc811\ucd09\ud560 \uc218 \uc788\ub294 \ucd5c\ucd08\uc758 \uae30\ud68c\uac00 \ub418\uc5c8\uc5b4\uc694. \ub2f9\uc2dc \ud504\ub791\uc2a4\uc758 \uacac\uc9c1 \uc0b0\uc5c5\uc740 \uc804\uc5fc\ubcd1\uc73c\ub85c \ud669\ud3d0\ud654\ub418\uace0 \uc788\uc5c8\ub294\ub370, \uc0c1\uc5c5\uc801\uc73c\ub85c \uc774\uc6a9\ub418\ub358 \ub204\uc5d0\ub4e4\uc774 \ub300\ub7c9\uc73c\ub85c \ubcd1\uc5d0 \uac78\ub824 \uc8fd\uc5b4\uac00\uace0 \uc788\uc5c8\ub358 \uac83\uc774\uc8e0. 1856\ub144\uc5d0 \ud504\ub791\uc2a4 \ub18d\ubb34\ubd80\ub294 \ub204\uc5d0 \uc804\uc5fc\ubcd1 \uc5f0\uad6c \ud504\ub85c\uc81d\ud2b8\ub97c \uc2dc\uc791\ud588\uace0 \ud30c\uc2a4\ud1f4\ub974\uac00 \uadf8 \uc5f0\uad6c\ub97c \uc774\ub04c\ub3c4\ub85d \uc120\uc784\ub418\uc5c8\uc5b4\uc694. \uc544\ubb34\ub3c4 \ub204\uc5d0\uc758 \ud45c\ud53c\uc5d0 \uac80\uc740 \uc0c9\uc758 \uc791\uc740 \ubc18\uc810\uc774 \uc0dd\uae30\uac8c \ud558\ub294 \uadf8 \ubcd1\uc758 \uc6d0\uc778\uc744 \ubab0\ub790\uc8e0. \ud30c\uc2a4\ud1f4\ub974\ub294 \ud504\ub85c\uc81d\ud2b8 \ucd08\uae30\uc5d0 \uc138\uade0\uc740 \ub204\uc5d0\uc758 \ubcd1\uacfc \ubb34\uad00\ud558\ub2e4\uace0 \ubbff\uace0 \uadf8 \ubb38\uc81c\ub97c \uc5f0\uad6c\ud558\uae30 \uc2dc\uc791\ud588\uc5b4\uc694. \uc804\uc5fc\ub41c \ub204\uc5d0\uc640 \ubc88\ub370\uae30 \uadf8\ub9ac\uace0 \uac70\uae30\uc11c \ub098\uc628 \ub098\ubc29\uc5d0\uc11c &#8216;\ubbf8\uc18c \uc785\uc790&#8217;\uac00 \ubc1c\uacac\ub418\uc5c8\uc9c0\ub9cc \uadf8\ub294 \uadf8 \ubcd1\uc774 \ub2e8\uc9c0 \ub204\uc5d0\uc758 \uc0dd\ub9ac\uc801 \ubb38\uc81c\ub77c\uace0 \uc0dd\uac01\ud588\uc5b4\uc694. \uadf8\ub7ec\ub098 \uba87 \ub144\uac04\uc758 \uc2e4\ud5d8 \ud6c4\uc5d0 \ud30c\uc2a4\ud2f0\ub974\ub294 \ud504\ub791\uc2a4 \uacac\uc9c1 \uc0b0\uc5c5\uc744 \ub9dd\uce58\ub294 \uc5f0\ud654\ubcd1\uacfc \ubbf8\ub9bd\uc790\ubcd1\uc758 \uc6d0\uc778\uc73c\ub85c \ubbf8\uc18c \uc720\uae30\uccb4\ub97c \ud655\uc778\ud588\uc5b4\uc694. \uadf8\uc758 \uc2e4\ud5d8\uc801 \ubc1c\uacac\uc758 \uae30\ucd08 \uc704\uc5d0\uc11c \uadf8\ub294 \uadf8 \ubcd1\uc744 \uc81c\uac70\ud560 \ucd5c\uc120\uc758 \uc218\ub2e8\uc5d0 \uad00\ud558\uc5ec \uacac\uc9c1 \uc0b0\uc5c5\uc5d0\uc11c \uc77c\ud558\ub294 \uc0ac\ub78c\ub4e4\uc5d0\uac8c \uc870\uc5b8\ud588\uace0 \uc774\ub85c\uc368 \ud504\ub791\uc2a4\uc640 \uc720\ub7fd\uc758 \ub2e4\ub978 \ub098\ub77c\ub4e4\uc758 \uacac\uc9c1 \uc0b0\uc5c5\uc5d0 \uc911\uc694\ud55c \uae30\uc5ec\ub97c \ud588\ub2f5\ub2c8\ub2e4.<\/p>\n<p style=\"text-align: left;\">\uadf8\ub7f0\ub370, \ud30c\uc2a4\ud1f4\ub974\uc758 \ub204\uc5d0 \uc804\uc5fc\ubcd1\uc758 \ud0d0\uad6c\ub294 \ub354 \ud070 \ub3d9\ubb3c\ub4e4\uacfc \uc778\uac04\uc5d0 \ub300\ud55c \uc9c8\ubcd1\uc758 \uc138\uade0\uc774\ub860\uc744 \uc2e4\ud5d8\uc801\uc73c\ub85c \ud655\uc99d\ud558\uae30 \uc704\ud55c \ub514\ub524\ub3cc\uc774 \ub418\uc5c8\uc5b4\uc694. 1876\ub144\uc5d0 \ud30c\uc2a4\ud1f4\ub974\ub294 \uc67c\ud3b8\uc774 \ub9c8\ube44\ub418\ub294 \uc911\ud48d\uc73c\ub85c \uace0\ud1b5\ubc1b\ub294 \ubcd1\uc790\uc600\uc74c\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \ud504\ub791\uc2a4\uc758 \uc591\uc758 \uc218\ub97c \uaca9\uac10\uc2dc\ud0a4\ub294 \ubb34\uc11c\uc6b4 \ubcd1\uc778 \ud0c4\uc800\ubcd1\uc5d0 \ub300\ud55c \uc2e4\ud5d8\uc801 \uc5f0\uad6c\ub97c \uc218\ud589\ud558\uae30\ub85c \ud588\uc5b4\uc694. 10\uc5ec \ub144 \uc804\uc5d0 \ub2e4\ub978 \uacfc\ud559\uc790\ub4e4\uc774 \ud0c4\uc800\ubcd1\uc5d0 \uac78\ub9b0 \uc591\uc758 \ud53c\uc5d0\uc11c \ub9c9\ub300 \ubaa8\uc591\uc758 \ubbf8\uc18c \uc720\uae30\uccb4\ub97c \ubc1c\uacac\ud588\uace0, \ud0c4\uc800\ubcd1\uc5d0 \uac78\ub9b0 \uc591\ub4e4\uc758 \ud53c\uac00 \uac74\uac15\ud55c \uc591\uc5d0 \uc8fc\uc785\ub418\uc5c8\uc744 \ub54c \ud0c4\uc800\ubcd1\uc774 \uc720\ubc1c\ub418\ub294 \uac83\uc774 \ubc1d\ud600\uc9c0\uae34 \ud588\uc9c0\ub9cc, \uc774 \uc2e4\ud5d8\uc5d0 \ub300\ud55c \ub17c\uc7c1\uc774 \uc788\uc5c8\uace0 \uc790\uc5f0\ubc1c\uc0dd\uacfc \ubc1c\ud6a8\uc5d0 \uad00\ud55c \uc5f0\uad6c\uc5d0\uc11c\ucc98\ub7fc \uc5bb\uc5b4\uc9c4 \uacb0\uacfc\uac00 \uc138\uade0\uc774\ub860\uc758 \ubc18\ub300\uc790\ub4e4\uc744 \ub9cc\uc871\uc2dc\ud0ac \ub9cc\ud07c \uacb0\uc815\uc801\uc774\uc9c0 \ubabb\ud588\ub2f5\ub2c8\ub2e4.<\/p>\n<p style=\"text-align: left;\">\ud30c\uc2a4\ud1f4\ub974\uac00 \ud0c4\uc800\ubcd1\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub97c \uc2dc\uc791\ud588\uc744 \ub54c, \ub3c5\uc77c\uc758 \uc758\uc0ac \ub85c\ubca0\ub974\ud2b8 \ucf54\ud750(1843-1910, 1905\ub144 \ub178\ubca8\uc0dd\ub9ac\ud559\uc758\ud559\uc0c1 \uc218\uc0c1)\ub294 \uadf8 \ubcd1\uc744 \uc9d1\uc911\uc801\uc73c\ub85c \uc5f0\uad6c\ud558\uace0 \uc788\uc5c8\uc5b4\uc694. \ucf54\ud750\ub294 \ud30c\uc2a4\ud1f4\ub974\uc640 \ud568\uaed8 \uc9c8\ubcd1\uc758 \uc138\uade0\uc774\ub860\uc744 \ud655\uc99d\ud558\uace0 \uc624\ub298\ub0a0 \uc6b0\ub9ac\ub97c \ub9ce\uc740 \ubb34\uc11c\uc6b4 \uc138\uade0\uc131 \uc9c8\ud658\uc5d0\uc11c \uc790\uc720\ub86d\uac8c \ud588\ub2e4\ub294 \uc778\uc815\uc744 \ubc1b\uace0 \uc788\ub294 \uacfc\ud559\uc790\ub78d\ub2c8\ub2e4. \ucf54\ud750\ub294 \ud0c4\uc800\ubcd1\uc5d0 \uac10\uc5fc\ub41c \uc591\uc758 \ud53c\uc5d0\uc11c \ubc1c\uacac\ub41c \ubbf8\uc18c\ud55c \ub9c9\ub300\ub97c \ud1a0\uae30\uc758 \ud53c\ub098 \ud1a0\ub07c\uc758 \ub208\uc5d0\uc11c \ucc44\ucde8\ud55c \uc561\uc5d0\uc11c \ud0a4\uc6e0\uc5b4\uc694. \uadf8\ub294 \ud604\uc7ac \ud0c4\uc800\ubcd1 \ubc14\uc2e4\ub8e8\uc2a4\ub85c \uc54c\ub824\uc9c4 \uc774 \ub9c9\ub300\ub4e4\uc744 \uc0dd\uc950\uc5d0 \uc8fc\uc785\ub418\uc5c8\uc744 \ub54c \ud0c4\uc800\ubcd1\uc774 \uc720\ubc1c\ub428\uc744 \ubc1d\ud600\ub0b4\uc5c8\uace0 \uac10\uc5fc\ub41c \uc0dd\uc950\uc5d0\uc11c \ub354 \ub9ce\uc740 \ubc14\uc2e4\ub8e8\uc2a4\ub97c \ubc1c\uacac\ud560 \uc218 \uc788\uc5c8\uc5b4\uc694.\u00a0 \uac74\ucd08 \uac19\uc740 \ub2e4\ub978 \ucd9c\ucc98\uc5d0\uc11c \ucc44\ucde8\ub41c \ub9c9\ub300 \ubaa8\uc591\uc758 \ubc15\ud14c\ub9ac\uc544\ub294 \ud0c4\uc800\ubcd1\uc744 \uc720\ubc1c\ud558\uc9c0 \uc54a\uc558\ub294\ub370, \ucf54\ud750\ub294 \uc774\uac83\uc774 \ud0c4\uc800\ubcd1\uc774 \ud2b9\uc815\ud55c \uc720\ud615\uc758 \ubc14\uc2e4\ub8e8\uc2a4\uc5d0 \uc758\ud574\uc11c \uc57c\uae30\ub418\ub294 \uac83\uc744 \uc758\ubbf8\ud558\ub294 \uac83\uc73c\ub85c \uc62c\ubc14\ub974\uac8c \ud574\uc11d\ud588\uc5b4\uc694. \ucf54\ud750\ub294 \ud0c4\uc800\ubcd1 \ubc14\uc2e4\ub8e8\uc2a4\uc758 \uc804\uccb4 \uc0dd\ud65c\uc0ac\ub97c \ubc1d\ud600\ub0c8\ub294\ub370, \uadf8\ub294 \uadf8\uac83\ub4e4\uc774 \ub098\ub204\uc5b4 \uc84c\uc744 \ub54c \uac00\ub294 \uc2e4 \ubaa8\uc591\uc758 \ub9c9\ub300\ub97c \ud615\uc131\ud558\ub294 \uac83\uc744 \uad00\ucc30\ud588\uace0, \uadf8\uac83\ub4e4\uc774 \uc6d0\ud615\uad6c\uc870\ub85c \ubcc0\ud55c \uac83\ub3c4 \uad00\ucc30\ud588\uc5b4\uc694.<\/p>\n<p style=\"text-align: left;\">\ud53c\ub098 \ub208\ubb3c\uc5d0\uc11c \ud0c4\uc800\ubcd1 \ubc14\uc2e4\ub8e8\uc2a4\ub97c \ud0a4\uc6c0\uc73c\ub85c\uc368 \ucf54\ud750\ub294 \ubcd1\uc778\uc131 \ubbf8\uc0dd\ubb3c\uc744 \ubd84\ub9ac\ud558\uc5ec \uadf8\uac83\uc744 \ub3d9\ubb3c\uccb4 \uc678\uc5d0\uc11c \ubc30\uc591\ud558\ub294 \uc911\uc694\ud55c \uc9c4\ubcf4\ub97c \uc774\ub8e8\uc5c8\uc5b4\uc694. \uc774\uc81c\ub294 \uc138\uade0\uc774 \uc9c8\ubcd1\uc744 \uc720\ubc1c\ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c \uadf8\uac83\uc774 \ubc30\uc591\ub420 \uc218\ub3c4 \uc788\uace0 \ub2e4\ub978 \ub3d9\ubb3c\uacfc\ub294 \ubb34\uad00\ud558\uac8c \ub300\ub7c9\uc73c\ub85c \uc5f0\uad6c\ub420 \uc218 \uc788\uc74c\uc774 \ud655\uc2e4\ud574\uc9c4 \uac83\uc774\uc8e0. \ud558\uc9c0\ub9cc, \uc5b4\ub5a4 \uacfc\ud559\uc790\ub4e4\uc740 \uc5ec\uc804\ud788 \ucf54\ud750\uc758 \uc5f0\uad6c\uc5d0 \ube44\ud310\uc801\uc774\uc5c8\uc5b4\uc694. \uadf8\ub4e4\uc740 \ud0c4\uc800\ubcd1\uc774 \ubc14\uc2e4\ub8e8\uc2a4\uc5d0 \uc758\ud574\uc11c\uac00 \uc544\ub2c8\ub77c \uac10\uc5fc\ub41c \ub3d9\ubb3c\uc5d0\uc11c \ud53c\uac00 \ucc44\ucde8\ub420 \ub54c \uadf8\uac83\uacfc \ud568\uaed8 \uc2e4\ub824\uc628 \ub2e4\ub978 \uc778\uc790\uc5d0 \uc758\ud574 \uc57c\uae30\ub418\ub294 \uac83\uc774\ub77c\uace0 \ubbff\uc5c8\uc5b4\uc694. \ud30c\uc2a4\ud1f4\ub974\ub294 \uc774 \ube44\ud310\uc5d0 \uace7 \uc751\ub2f5\ud558\uc600\uace0 \ucf54\ud750\uc758 \uc5f0\uad6c \uacb0\uacfc\uac00 \uc9c8\ubcd1\uc758 \uc138\uade0\uc774\ub860\uc744 \ud655\ub9bd\ud558\ub3c4\ub85d \ubcf4\ucda9\ud588\ub2f5\ub2c8\ub2e4. \ud30c\uc2a4\ud1f4\ub974\ub294 \ud0c4\uc800\ubcd1 \ubc14\uc2e4\ub8e8\uc2a4\ub97c \ubcc0\uc5d0\uc11c \ubc30\uc591\ud588\uace0 \ucd5c\ucd08\uc758 \ubc30\uc591\uc561\uc744 \uacc4\uc18d \ubb3d\uac8c \ud558\uc5ec \ubc14\uc2e4\ub8e8\uc2a4\uc640 \ud568\uaed8 \uc788\ub358 \ubc88\uc2dd\ud558\uc9c0 \uc54a\ub294 \uc624\uc5fc \uc778\uc790\uac00 \ud76c\uc11d\ub418\uc5b4 \ube60\uc838\ubc84\ub824 \ud558\ub098\ub3c4 \ub0a8\uc744 \uc218 \uc5c6\uc744 \ub54c\uae4c\uc9c0 \uacc4\uc18d\ud588\uc5b4\uc694. \ud0c4\uc800\ubcd1 \ubc14\uc2e4\ub8e8\uc2a4\uac00 \uacc4\uc18d\ud574\uc11c \uc790\ub77c\uace0 \uc788\uc5c8\ub358 \ubc30\uc591\uc561\uc740 \uc5ec\uc804\ud788 \ub3d9\ubb3c\uc5d0 \uac15\ud55c \uac10\uc5fc\uc744 \uc720\ubc1c\ud588\ub294\ub370, \uc774\uac83\uc740 \uc2e4\uc81c\ub85c \ubc14\uc2e4\ub8e8\uc2a4\uac00 \ud0c4\uc800\ubcd1\uc744 \uc720\ubc1c\ud558\ub294 \uac83\uc784\uc744 \uc758\uc2ec\uc758 \uc5ec\uc9c0\uc5c6\uc774 \ud569\ub9ac\uc801\uc73c\ub85c \uc785\uc99d\ud588\ub358 \uac83\uc774\uc8e0. \ub354\uc6b1\uc774 \ud30c\uc2a4\ud1f4\ub974\uac00 \uadf8\uc758 \ubc30\uc591\uc561\uc5d0\uc11c \ubc14\uc2e4\ub8e8\uc2a4\ub97c \uc5ec\uacfc\uc2dc\ucf1c \uc81c\uac70\ud588\uc744 \ub54c, \uadf8 \uc561\uc740 \uac10\uc5fc \ub2a5\ub825\uc744 \uc0c1\uc2e4\ud588\uc5b4\uc694. \uc774\uc640 \uac19\uc774 \uc9c8\ubcd1\uc758 \uc138\uade0\uc774\ub860\uc774 \ud655\ub9bd\ub418\uc790 \uacfc\ud559\uc790\ub4e4\uc740 \ucf54\ud750\uc640 \ud30c\uc2a4\ud1bc\ub974\uc5d0 \uc758\ud574 \uac1c\ubc1c\ub41c \ubc29\ubc95\uc744 \uc0ac\uc6a9\ud574 \ubbf8\uc0dd\ubb3c\uc774 \ud0c4\uc800\ubcd1 \uc678\uc758 \ubcd1\uc744 \uc57c\uae30\ud560 \uac00\ub2a5\uc131\uc744 \uc870\uc0ac\ud558\uae30 \uc2dc\uc791\ud558\uac8c \ub41c \uac83\uc774\uc8e0.<\/p>\n<p style=\"text-align: left;\">\uadf8\ub9ac\uace0 \uc9c8\ubcd1\uc758 \uc138\uade0\uc774\ub860\uc740 \uc218\uc220\uc758 \uc0c1\ucc98 \uc790\ub9ac\uc5d0 \uc788\ub294 \ubc15\ud14c\ub9ac\uc544\ub97c \uc8fd\uc774\uae30 \uc704\ud55c \uc0b4\uade0\ubc95\uc758 \uac1c\ubc1c\ub85c \uc774\uc5b4\uc84c\uc5b4\uc694. \uc601\uad6d \uc678\uacfc\uc758\uc0ac \ub9ac\uc2a4\ud130(1827-1912)\ub294 \ubd80\ud328\ub97c \uc57c\uae30\ud558\ub294 \ubbf8\uc0dd\ubb3c\uc5d0 \ub300\ud55c \ud30c\uc2a4\ud1f4\ub974\uc758 \uc5f0\uad6c\uc5d0 \uad00\ud574 \ub4e4\uc5c8\uace0, \uadf8\ub294 \ud30c\uc2a4\ud1f4\ub974\ucc98\ub7fc \ubbf8\uc18c \uc720\uae30\uccb4\uac00 \uc678\uc0c1\uc5d0 \uc885\uc885 \ub098\ud0c0\ub098\ub294 \ubb34\uc11c\uc6b4 \uac10\uc5fc\uc758 \uc6d0\uc778\uc774 \ub41c\ub2e4\uace0 \ubbff\uc5c8\uc5b4\uc694. 19\uc138\uae30 \uc911\uc5fd\uae4c\uc9c0 \uc678\uacfc \uc218\uc220\uc740 \uc758\ud559\uc801 \ubb38\uc81c\ub4e4\uc758 \uce58\ub8cc\uc5d0 \uc788\uc5b4 \ub9c8\uc9c0\ub9c9 \ubc29\ub3c4\ub77c\uace0 \uc0dd\uac01\ub418\uc5c8\uc73c\uba70, \uc678\uacfc\uc801 \uac1c\uc785\uc758 \uacb0\uacfc\ub85c \uc0dd\uae34 \uac10\uc5fc\uc73c\ub85c \uc778\ud55c \uc0ac\ub9dd\uc740 \uc608\uc678\uc801\uc778 \uac83\uc774 \uc544\ub2c8\ub77c \ub2f9\uc5f0\ud55c \uac83\uc73c\ub85c \uc5ec\uaca8\uc9c0\uace0 \uc788\uc5c8\uc8e0. \ub9ac\uc2a4\ud130\ub294 \uc774 \uac10\uc5fc\uc774 \ubbf8\uc0dd\ubb3c\uc5d0 \uc758\ud55c \uac83\uc774\ub77c\uba74 \ubbf8\uc0dd\ubb3c\uc744 \uc8fd\uc774\ub294 \ud654\ud559\uc801 \ucc98\ub9ac\ub97c \ud568\uc73c\ub85c\uc368 \uc218\uc220\uc5d0 \uc218\ubc18\ub418\ub294 \ubb38\uc81c\ub4e4\uc744 \uc904\uc77c \uc218 \uc788\uc73c\ub9ac\ub77c\uace0 \ucd94\ub860\ud588\uace0, 1864\ub144\uc5d0 \uc0b4\uade0 \uc218\uc220\ubc95\uc744 \uac1c\ubc1c\ud588\uc5b4\uc694. \uc11d\ud0c4\uc0b0 \ubd84\ubb34\uae30\ub85c \uac70\ub454 \uadf8\uc758 \uc131\uacf5\uc740 \ub300\ub2e8\ud588\ub294\ub370, \uadf8\ub294 \uc218\uc220 \uc774\ud6c4 \uac10\uc5fc\uacfc \uac10\uc5fc\uc5d0 \uc758\ud55c \uc0ac\ub9dd\uc758 \ubc1c\uc0dd\uc744 \uadf9\uc801\uc73c\ub85c \uc904\uc77c \uc218 \uc788\uc5c8\uace0, \ub9ac\uc2a4\ud130\uc758 \uc0b4\uade0 \uc218\uc220\ubc95\uc5d0\uc11c \uc138\uade0\uc774 \uc218\uc220 \uc790\uad6d\uc5d0 \uc811\uadfc\ud558\uc9c0 \ubabb\ud558\uac8c \ud558\ub294, \uc624\ub298\ub0a0\uc758 \uc218\uc220\uc2e4\uc5d0\uc11c \uc0ac\uc6a9\ub418\ub294 \uc5c4\uaca9\ud55c \uae30\uc900\uc774 \ub098\uc654\ub2f5\ub2c8\ub2e4.<\/p>\n<p style=\"text-align: left;\">\uc138\uade0\uc774 \uc9c8\ubcd1\uc744 \uc57c\uae30\ud560 \uc218 \uc788\ub2e4\ub294 \uac83\uc774 \ud655\uc2e4\ud574\uc9c0\uace0 \ub9ce\uc740 \uc6d0\uc778\uade0\uc774 \ubd84\ub9ac\ub418\uc790 \uba87\uba87 \uacfc\ud559\uc790\ub4e4\uc740 \uac10\uc5fc\ub41c \ub3d9\ubb3c\uc744 \uc8fd\uc774\uc9c0 \uc54a\uace0 \ubbf8\uc0dd\ubb3c\ub9cc \uc8fd\uc774\ub294 \ubb3c\uc9c8\uc774 \ub9cc\ub4e4\uc5b4\uc9c8 \uac00\ub2a5\uc131\uc744 \uace0\ub824\ud558\uae30 \uc2dc\uc791\ud588\uc5b4\uc694. \ub9ac\uc2a4\ud130\uc758 \uc0b4\uade0 \uc218\uc220\uc740 \ubc8c\uc368 \uc0c1\ucc98\uc758 \uac10\uc5fc\uc774 \uc138\uade0\uc744 \uc8fd\uc784\uc73c\ub85c\uc368 \uc608\ubc29\ub420 \uc218 \uc788\uc74c\uc744 \uc608\uc99d\ud588\uace0, 19\uc138\uae30 \ub9d0\uc5d0\ub294 \ub9ce\uc740 \ubcd1\ub4e4\uc774 \ube44\uc704\uc0dd\uc801 \uc0dd\ud65c \uc870\uac74\uacfc \uad00\ub828\ub418\uc5b4 \uc788\uace0 \uae68\ub057\ud55c \uc0dd\ud65c \uae30\uc900\uc774 \ub9ce\uc740 \uc804\uc5fc\ubcd1\uc744 \uc608\ubc29\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub41c\ub2e4\ub294 \uac83\uc774 \uc0c1\ub2f9\ud788 \ud655\uc2e4\ud574\uc84c\uc73c\uba70, \ucc9c\uc5f0\ub450\ub77c\ub294 \ubcd1\uc740 \ubc8c\uc368 \uc81c\ub108(1749-1823)\uc5d0 \uc758\ud574 \uac1c\ubc1c\ub41c \uc608\ubc29\uc811\uc885\ubc95\uc758 \uacb0\uacfc\ub85c \ub300\ub300\uc801\uc73c\ub85c \uc815\ubcf5\ub418\uace0 \uc788\uc5c8\uc8e0. \uadf8\ub807\uc9c0\ub9cc \ucc9c\uc5f0\ub450\uac00 \uc608\ubc29\uc811\uc885\uc5d0 \uc758\ud574 \uc608\ubc29\ub418\ub294 \uba54\ucee4\ub2c8\uc998\uc740 \ubaa8\ud638\ud558\uac8c \ub0a8\uc544 \uc788\uc5c8\uc5b4\uc694. \uc138\uade0\uc774\ub860\uc758 \ud655\ub9bd\uc740 \ub9ce\uc740 \uc804\uc5fc\ubcd1\uc5d0 \ub300\ud55c \ubc31\uc2e0\uc758 \uc0dd\uc0b0\uc73c\ub85c \uc774\uc5b4\uc9c0\uac8c \ub418\ub294\ub370, \ud30c\uc2a4\ud1f4\ub974\ub294 \uc774 \uc0c8\ub85c\uc6b4 \ubc31\uc2e0\uc758 \uac1c\ubc1c\uc5d0\uc11c \uc8fc\ub41c \uc5ed\ud560\uc744 \ud588\uc5b4\uc694. \uadf8\uc758 \ubc31\uc2e0\uc5d0 \ub300\ud55c \uacf5\ub85c\uc5d0 \ub300\ud574 \uc774\uc57c\uae30\ub97c \uc2dc\uc791\ud558\uae30 \uc804\uc5d0, \uadf8\uac00 \ubc31\uc2e0 \uc5f0\uad6c\ub97c \uc2dc\uc791\ud560 \ub54c\uae4c\uc9c0\uc758 \uc0c1\ud669\uc5d0 \ub300\ud574\uc11c \uc0b4\ud3b4\ubcfc\uac8c\uc694.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>(to be continued&#8230;)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h4 class=\"article-item__title serif\">The advent and rise of monoclonal antibodies<\/h4>\n<p>&nbsp;<\/p>\n<h5>A 1975\u00a0<i>Nature<\/i>\u00a0paper reported how cell lines could be made that produce an antibody of known specificity. This discovery led to major biological insights and clinical successes in treating autoimmunity and cancer.<\/h5>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div class=\"article__body serif cleared\">\n<p>In their\u00a0<a href=\"https:\/\/www.nature.com\/articles\/256495a0\" data-track=\"click\" data-label=\"https:\/\/www.nature.com\/articles\/256495a0\" data-track-category=\"body text link\">1975\u00a0<i>Nature<\/i>\u00a0paper<\/a><sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02840-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR1\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">1<\/a><\/sup>, the immunologists Georges K\u00f6hler and C\u00e9sar Milstein described the production of monoclonal antibodies of predetermined specificity, each made by a continuously growing cell line that had been generated by the fusion of an antibody-producing cell from an immunized mouse with an immortal cancer cell specialized for antibody secretion. Hearing from C\u00e9sar about this work before it was published, on the way to an obscure meeting in San Remo in Italy, I knew immediately that our research field had reached a turning point.<\/p>\n<p>&nbsp;<\/p>\n<aside class=\"recommended pull pull--left sans-serif\" data-label=\"Related\"><a href=\"https:\/\/www.nature.com\/articles\/256495a0\" data-track=\"click\" data-track-label=\"recommended article\"><img decoding=\"async\" class=\"recommended__image\" src=\"https:\/\/media.nature.com\/w400\/magazine-assets\/d41586-019-02840-w\/d41586-019-02840-w_17267972.jpg\" \/><\/a><\/aside>\n<\/div>\n<p class=\"recommended__title serif\">The paper: Continuous cultures of fused cells secreting antibody of predefined specificity<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>Antibodies were discovered in 1890 by the physiologist Emil von Behring and the microbiologist Shibasaburo Kitasato as protective antitoxins in the blood of animals exposed to diphtheria or tetanus toxin<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02840-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR2\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">2<\/a><\/sup>. Ever since, antibodies have been a major research subject, given their key role in adaptive immunity (specific immune responses against, for example, invading disease-causing agents) and their wide range of specificities, essentially covering the universe of chemical structures. This had stood out from early on as a major genetic puzzle. How can our limited genome encode a seemingly limitless repertoire of specificities? And in medical (and industrial) practice, antibodies have been used ever since their discovery as the basis for serum therapy (the treatment of infectious diseases using blood serum from immunized animals), as diagnostic tools to monitor infectious disease, and in innumerable other contexts.<\/p>\n<p>But antibodies specific for any given molecule (called an antigen in the context of an antibody response) came, with a few notable exceptions, as mixtures of antibodies, produced by thousands of antibody-producing cells in an immunized animal or infected person. Each of these cells produced an antibody of its own kind, so that \u2018antibody specificity\u2019 usually referred to the properties of antibody populations rather than those of individual antibodies. The inability to produce molecularly defined, homogeneous antibodies of predetermined specificity was a major hurdle that needed to be overcome.<\/p>\n<div class=\"c-podcast sans-serif\">\n<div class=\"embed intensity--high\">\n<div class=\"c-podcast__container\"><\/div>\n<div class=\"c-podcast__download-transcript text14\">\n<div class=\"c-podcast__transcript\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>This changed overnight with K\u00f6hler and Milstein\u2019s paper. K\u00f6hler had joined Milstein\u2019s group at the MRC Laboratory of Molecular Biology in Cambridge, UK, as a postdoc, to study the mechanism of somatic mutation that operates in antibody diversification. The plan was to use mouse myeloma cells for this purpose. These are tumour cells originating from antibody-secreting immune cells. The cancer immunologist Michael Potter at the National Cancer Institute in Bethesda, Maryland, had shown years before that myelomas could be induced in a particular mouse strain by the injection of mineral oil<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02840-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR3\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">3<\/a><\/sup>. The Milstein team was propagating and fusing to each other cells obtained from cell lines derived from various such tumours. However, the myeloma antibodies were ill-defined in terms of specificity. Could one perhaps fuse antibody-producing cells from immunized mice to myeloma cells, to produce continuously dividing cells that make antibodies specific for the immunizing antigen? To detect such fused cells, an approach offered itself which K\u00f6hler had become acquainted with during his PhD at the Basel Institute for Immunology in Switzerland and that had been developed by the institute\u2019s director, Niels Jerne<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02840-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR4\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">4<\/a><\/sup>. This was a simple technique in which cells secreting antibodies in response to, and specific for, sheep red blood cells (SRBCs) can be identified by the formation of a clearance (called a plaque)in SRBC-containing agar plates.<\/p>\n<p>With this, the stage was set for the K\u00f6hler\u2013Milstein experiment (Fig. 1). Large numbers of plaque-forming hybrid cells secreting anti-SRBC antibodies appeared when spleen cells from SRBC-immunized mice were fused with myeloma cells. The fused cells had acquired expression of a single type of anti-SRBC antibody from a spleen cell and preserved the immortality and high rate of antibody secretion of the myeloma fusion partner. Myeloma and spleen cells were unable to multiply under the chosen experimental conditions, and the myeloma cells apparently preferred antigen-activated spleen cells over others for fusion, a prerequisite for the striking success of the experiment.<\/p>\n<p>&nbsp;<\/p>\n<figure class=\"figure\">\n<div class=\"embed intensity--high\">\n<div class=\"embed intensity--high\"><img decoding=\"async\" class=\"figure__image\" src=\"https:\/\/media.nature.com\/w800\/magazine-assets\/d41586-019-02840-w\/d41586-019-02840-w_17345474.png\" alt=\"\" data-src=\"\/\/media.nature.com\/w800\/magazine-assets\/d41586-019-02840-w\/d41586-019-02840-w_17345474.png\" \/><\/div>\n<\/div><figcaption>\n<p class=\"figure__caption sans-serif\"><span class=\"mr10\"><b>Figure 1 | The production of monoclonal antibodies.<\/b>\u00a0K\u00f6hler and Milstein\u2019s 1975\u00a0<i>Nature<\/i>\u00a0paper<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02840-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR1\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">1<\/a><\/sup>\u00a0solved the problem of how to generate clones of continuously dividing cells that make antibodies of a known specificity. The ability to generate such monoclonal antibodies revolutionized antibody research and paved the way to clinical advances. The authors injected mice with sheep red blood cells and isolated spleen cells, including those that produce antibodies. Different antibody colours indicate antibodies specific for different molecules (antigens), and produced by different cells. The authors had the idea of fusing antibody-producing spleen cells of limited lifespan with myeloma cells \u2014 immortal cancerous immune cells secreting antibodies of unknown specificity. Spleen cells that had been activated upon antigen recognition fused preferentially with the myeloma cells, generating hybrid cells called hybridomas. Unlike unfused cells, the hybridoma cells could grow on the selective agar plates used, and formed colonies of identical cells. Hybridomas that secreted antibodies specific for sheep red blood cells were identified by their ability to destroy such cells when added to the agar, generating a clearance (plaque). These original hybridoma cells made two types of antibody, one that recognized sheep red blood cells and another of unknown specificity.<\/span><\/p>\n<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>The fused cells could be cloned and propagated indefinitely as what were later termed hybridomas, producing unlimited amounts of monoclonal antibodies. The first-generation hybridomas secreted two types of antibody: the desired one, plus an antibody of unknown specificity originating from the myeloma fusion partner. But this two-antibody problem was soon solved through the isolation of myeloma lines that had lost antibody expression<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02840-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR5\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">5<\/a><\/sup><sup>,<\/sup><sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02840-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR6\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">6<\/a><\/sup>.<\/p>\n<p>Antibodies against any desired antigen could now be generated, investigated and used as homogeneous molecular entities. In 1984, K\u00f6hler and Milstein won the Lasker Award together with Potter, and that same year K\u00f6hler, Milstein and Jerne were awarded the Nobel Prize in Physiology or Medicine.<\/p>\n<p>The impact of the K\u00f6hler\u2013Milstein paper on biomedical and, specifically, immunological research was dramatic, propelled by scientific developments that occurred around the time the paper appeared. Thus, it became clear shortly afterwards that the variable and constant regions of antibodies are encoded by separate gene segments. Antibody diversity arises when somatic recombination joins gene segments together, and when a subsequent process called somatic hypermutation operates, during the course of the antibody response, on the recombined gene segments encoding antibody variable regions. Together, these mechanisms generate a vast repertoire of antibody specificities, as well as distinct classes of antibody, which mediate their various roles (effector functions) through their differing constant regions.<\/p>\n<aside class=\"recommended pull pull--left sans-serif\" data-label=\"Related\"><\/aside>\n<p>These insights were accompanied by the explosive development of new molecular and genetic tools that allowed the isolation and manipulation of antibody genes in multiple ways. Together with the hybridoma technology, they fuelled a rapidly growing and still expanding field of investigation, in which basic research on antibody diversification and effector function goes hand-in-hand with the production and engineering of monoclonal antibodies for diagnostic and therapeutic purposes.<\/p>\n<p>In the early days, the production of monoclonal antibodies was entirely based on hybridoma technology and used for two main purposes: to study the somatic evolution of the antibody repertoire and the molecular basis of antibody specificity; and to generate reagents that bind to specific proteins or other molecules expressed by cells of the body or by pathogens. In both cases, completely new insights and technical advances resulted. Thus, affinity maturation of antibodies (the increase of antibody affinity during the course of an antibody response) began to be understood at the molecular level. And the technique of fluorescence-activated cell sorting was revolutionized by monoclonal antibodies, allowing the separation of different cell types at an unprecedented level of specificity and resolution. Recent highlights in this area include approaches allowing gene-expression profiling of single cells that have been characterized by the expression of large arrays of surface-marker proteins through cocktails of DNA-tagged, \u2018barcoded\u2019 monoclonal antibodies<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02840-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR7\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">7<\/a><\/sup>.<\/p>\n<p>In medicine, monoclonal antibodies have an ever-increasing role and have generated a multibillion-dollar market, which is expected to grow substantially in the future. In addition to their impact on medical diagnosis, the therapeutic application of antibodies has led to spectacular successes in the treatment of autoimmune diseases and cancer. The 2018 Nobel Prize in Physiology or Medicine was awarded for the \u201cdiscovery of cancer therapy by [antibody-mediated] inhibition of negative immune regulation\u201d. As often happens in biology, both the mechanisms and the efficient induction of the inhibitory processes underlying this type of immunotherapy are still unclear, with ongoing research providing challenges and new perspectives that are driving the development of monoclonal antibodies against additional targets.<\/p>\n<p>Monoclonal antibodies are also being developed to control infectious diseases \u2014 following the concept of protective antibodies that goes back to von Behring and Kitasato. Prevalent diseases such as malaria, influenza and AIDS call for the development of what are termed broadly neutralizing monoclonal antibodies, which, applied individually or in cocktails, might provide broad protection<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02840-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR8\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">8<\/a><\/sup>.<\/p>\n<p>Intensive work in this direction has yielded promising results, including engineering antibody specificity through the substitution of variable domains by ligand-binding domains from non-antibody receptors<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02840-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR9\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">9<\/a><\/sup>. Yet the immune system itself uses similar tricks<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02840-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR10\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">10<\/a><\/sup>\u00a0and, by and large, antibody design is still unable to outdo it in terms of generating and selecting antibody specificities<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02840-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR11\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">11<\/a><\/sup>. Nevertheless, the manifold modern molecular, cellular and genetic approaches to selecting and engineering antibodies have had, and continue to have, a tremendous impact on the field, whether by producing partly or fully human antibodies of different classes, making bi-specific or toxin-conjugated antibodies for specific therapeutic purposes, or incorporating antibody variable regions into chimaeric antigen receptors on T cells for use in an anticancer treatment called CAR-T cell therapy.<\/p>\n<p>Monoclonal antibodies are nowadays often generated by isolating or transforming antibody-producing cells taken directly from immunized animals or patients, and transplanting the antibody-encoding genes of these cells into suitable producer cell lines, rather than using hybridoma technology<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02840-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR12\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">12<\/a><\/sup><sup>\u2013<\/sup><sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02840-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR14\" data-track=\"click\" data-action=\"anchor-link\" data-track-label=\"go to reference\" data-track-category=\"references\">14<\/a><\/sup>. But they started their spectacular career in 1975, secreted by hybridoma cells in K\u00f6hler and Milstein\u2019s SRBC-containing agar plates.<\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"emphasis\">Nature<\/span>\u00a0<strong>575<\/strong>, 47-49 (2019)<\/p>\n<div class=\"emphasis\">doi: 10.1038\/d41586-019-02840-w<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>(\uc6d0\ubb38: <a href=\"https:\/\/www.nature.com\/articles\/d41586-019-02840-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29\">\uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>(\uc6d0\ubb38: <a href=\"https:\/\/m.blog.naver.com\/wondong95\/30170517553\">\uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n<p>&nbsp;<\/p>\n<div class=\"post_tit_area\">\n<div class=\"tit_area \">\n<h3 class=\"tit_h3\">\uc138\ud3ec\uc735\ud569\uae30\uc220\uc5d0 \uc758\ud55c \uc554\uc138\ud3ec\uc758 \uce58\ub8cc\uae30\uc804\uc5d0 \ub300\ud558\uc5ec<\/h3>\n<\/div>\n<\/div>\n<div id=\"viewTypeSelector\" class=\"post_ct \">\n<p>&nbsp;<\/p>\n<p>\uc138\ud3ec\uc735\ud569\uae30\uc220\uc5d0 \uc758\ud55c \uc554\uc138\ud3ec\uc758 \uce58\ub8cc\uae30\uc804\uc5d0 \ub300\ud558\uc5ec<\/p>\n<p>&nbsp;<\/p>\n<p>\uc81c1\uc7a5 \uba38\ub9ac\ub9d0<\/p>\n<p>\ucd5c\uadfc \ubc14\uc774\uc624\ud14c\ud06c\ub180\ub7ec\uc9c0\uc758 \ubc1c\ub2ec\ub85c \uc778\ud558\uc5ec \uc720\uc804\uacf5\ud559\uc758 \uae30\uc220\ub3c4 \uace0\ub3c4\ub85c \ubc1c\uc804\ud558\uace0 \uc788\ub2e4. \ud2b9\ud788, \uc138\ud3ec\uc735\ud569\ubc95\uc740 \uc138\ud3ec \uacf5\ud559\uc758 \ud575\uc2ec\uc73c\ub85c \ubd80\uc0c1\ud558\uace0 \uc788\ub2e4. \uc138\ud3ec \uc735\ud569\uc774\ub77c\ub294 \uac83\uc740\u00a0 \ub450 \uac1c\uc758 \uc138\ud3ec\ub97c \ud558\ub098\uc758 \uc138\ud3ec\ub85c \ub9cc\ub4dc\ub294 \uae30\uc220\uc774\ub2e4. \uc6b0\uc120 \uc138\ud3ec\uc9c8\uc758 \uc735\ud569\uc774 \uc774\uc6b0\ub7ec\uc9c0\uace0 \ub098\uc911\uc5d0 \ud575\uc758 \uc735\ud569\ub3c4 \uc774\ub8e8\uc5b4\uc9c4\ub2e4. \uc138\ud3ec \uc735\ud569\uc73c\ub85c \uc778\ud558\uc5ec \uc735\ud569\uc5d0 \uc0ac\uc6a9\ub418\ub294 2\uac1c\uc758 \uc138\ud3ec\uc640 \uc804\ud600 \ub2e4\ub978 \uc989 \ud615\uc9c8\uc804\ud658\uc138\ud3ec\uac00 \ub9cc\ub4e4\uc5b4\uc9c4\ub2e4.\u00a0 \ud2b9\ud788, \uc554\uc138\ud3ec\uc640 \uc815\uc0c1\uc138\ud3ec\uc758 \uc735\ud569\uae30\uc220\uc774 \uc774\ubbf8 \uac1c\ubc1c\ub418\uc5c8\uace0, \uc778\uccb4\uba74\uc5ed\uc744 \uae30\ub2a5\uc744 \ub2f4\ub2f9\ud558\ub294 B \uc138\ud3ec\uc640\u00a0 \uc554\uc138\ud3ec(\uace8\uc218\uc885\uc138\ud3ec\/melanoma cell)\uc640 \uc735\ud569\ud558\uc5ec\u00a0 \ud558\ub098\uc758 \ud56d\uc6d0\uacb0\uc815\uae30\uc640 \uacb0\ud569\ud558\ub294 \ubaa8\ub178\ud074\ub85c\ub110 \ud56d\uccb4\uc138\ud3ec\ub97c \ub9cc\ub4dc\ub294 \uae30\uc220\ub3c4 \uac1c\ubc1c\ub418\uc5c8\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\uc81c2\uc7a5 \uc138\ud3ec\uc735\ud569\uc758 \uc791\uc6a9\uc6d0\ub9ac\uc5d0 \ub300\ud558\uc5ec<\/p>\n<p>(1) \uc138\ud3ec \uc735\ud569\uc740 \ubc14\uc774\ub7ec\uc2a4\ub97c \uc774\uc6a9\ud558\uac70\ub098 \uacc4\uba74\ud65c\uc131\uc81c\uc758 \uc77c\uc885\uc778 \ud3f4\ub9ac\uc5d0\ud2f8\ub80c \uae00\ub9ac\ucf5c(PEG)\uc744 \uc0ac\uc6a9\ud55c\ub2e4. \uc138\ud3ec \uc735\ud569\uc740 \uc131\uc0c1\uc774 \uc11c\ub85c \ub2e4\ub978 2\uac1c\uc758 \uc138\ud3ec\ub97c \uc735\ud569\uc2dc\ucf1c \uc804\ud600 \uc0c8\ub85c\uc6b4 \uae30\ub2a5\uc744 \uac00\uc9c4 \uc138\ud3ec\ub97c \ub9cc\ub4dc\ub294 \ud601\uc2e0\uc801\uc778 \uae30\uc220\uc774\ub2e4. \uc778\uacf5\uc790\uc678\uc120\uc5d0 \uc758\ud558\uc5ec \ubd88\ud65c\uc131(\ubcf5\uc81c\ub2a5\ub825 \ub0b4\uc9c0 \uc99d\uc2dd\ub2a5\ub825\uc774 \uc5c6\ub294 )\uc2dc\ud0a8 \uc13c\ub2e4\uc774\ubc14\uc774\ub7ec\uc2a4\ub97c \uc554\uc138\ud3ec\uc640 \ud63c\ud569\ud558\uba74 \uace0\ube48\ub3c4\ub85c \uc554\uc138\ud3ec\uac00 \uc735\ud569\ub418\ub294 \ud604\uc0c1\uc774 \ub098\uc628 \uac83\uc744 \uacc4\uae30\ub85c \uc138\ud3ec \uc735\ud569\uae30\uad74\uc774 \ud0c4\uc0dd\ud558\uc600\ub2e4.<\/p>\n<p>(2) \ubc14\uc774\ub7ec\uc2a4 \uc678\ub9c9\uc5d0 \ub3cc\ucd9c\ub418\uc5b4 \uc788\ub294 \ub2e8\ubc31\uc9c8\ubd80\ubd84\uc774 \uc554\uc138\ud3ec\uc758 \uc138\ud3ec\ub9c9\uc704\uc5d0 \uc874\uc7ac\ud558\ub294 \ub2e8\ubc31\uc9c8 \ubd80\ubd84\uacfc \uc811\ucd09\ud558\uba74 \ub2e8\ubc31\uc9c8\uc758 \uc751\uc9d1\uc774 \uc77c\uc5b4\ub098 \uacb0\uad6d \uc138\ud3ec\ub9c9\uac04\uc758 \uc5f0\uacb0\uc774 \uac1c\uc2dc\ub418\uc5b4 \uc138\ud3ec\ub9c9\uc758 \uacb0\ud569\uc774 \uc774\ub8e8\uc5b4\uc9c4\ub2e4. \ub2e4\uc2dc \ub9d0\ud574\uc11c, 2\uac1c\uc758 \uc138\ud3ec\uc758 \uc9c0\uc9c8\uc774\uc911\uce35\uc774 \ucf5c\ub85c\uc774\ub4dc\ubd84\uc0b0(micelle) \uc0c1\ud0dc\uc758 \ud558\ub098\ub85c \ub418\uc5b4 \uc138\ud3ec\uc9c8\uc774 \ud569\ub958\ub418\uc5b4 \uacb0\uad6d \ud558\ub098\uc758 \uc138\ud3ec\ub0b4\uc5d0 2\uac1c\uc758 \ud575\uc774 \uc874\uc7ac\ud558\ub294 \uc138\ud3ec\uac00 \ub9cc\ub4e4\uc5b4\uc9c4\ub2e4. \uc774\ub97c \ud569\uc131 \uc138\ud3ec \ub0b4\uc9c0 \uc7a1\uc885\uc138\ud3ec\ub77c\uace0 \ud55c\ub2e4. \uc735\ud569\uc138\ud3ec\ub294 2\uac1c\uc758 \uc138\ud3ec\uc758 \uc5fc\uc0c9\uccb4\ub97c \ub3d9\uc2dc\uc5d0 \uac00\uc9c0\uace0 \uc788\uae30 \ub54c\ubb38\uc5d0 2\uac1c\uc758 \ud45c\ud604\ud615\uc774 \ubc1c\ud604\ub41c\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p>\uc81c3\uc7a5 \uc138\ud3ec\uc735\ud569\uae30\uc220\uc758 \ub2e8\uacc4\uc801 \ubc1c\uc804\uc5d0 \ub300\ud558\uc5ec<\/p>\n<p>\uc138\ud3ec\uc735\ud569\uc740 \ucc98\uc74c\uc5d0\ub294 \uc120\ub2e4\uc774 \ubc14\uc774\ub7ec\uc2a4\uc5d0 \uc758\ud558\uc5ec \ucc98\uc74c \uc2dc\ub3c4\ub418\uc5c8\ub2e4.\u00a0 \ubd84\uc790\uc0dd\ubb3c\ud559\uc758 \ubc1c\uc804\uc73c\ub85c \uc778\ud558\uc5ec \uccb4\uc678\uc5d0\uc11c(in vitro) \ub300\ub7c9\uc73c\ub85c \uc735\ud569\uc138\ud3ec\ub97c \ub9cc\ub4dc\ub294 \uae30\uc220\uc774 \ub098\uc654\ub2e4. \ubc14\ub85c \ud3f4\ub9ac\uc5d0\ud2f8\ub80c \uae00\ub9ac\ucf5c(PEG)\uc744 \uc2dc\ud5d8\uad00\uc5d0 \ub123\uace0 \uac01 \uc138\ud3ec\ub97c \uc6d0\uc2ec\ubd84\ub9ac\uae30\ub97c \ud1b5\ud558\uc5ec \uc138\ud3ec \ubd84\ud68d\uc744 \ud558\uc5ec \uc704 \uc2dc\ud5d8\uad00\uc5d0 \ub123\uc73c\uba74 \uc77c\ub2e8 \uc138\ud3ec\uc9c8\uc758 \uc735\ud569\uc774 \uc77c\ub098\ub098\uace0 \ub098\uc911\uc5d0 \uc138\ud3ec\ud575\uc758 \uc735\ud569\uc774 \uc77c\uc5b4\ub098 \uc644\uc804\ud788 \uc0c8\ub85c\uc6b4 \ud615\uc9c8\uc758 \uc735\ud569\uc138\ud3ec\uac00 \ub098\uc624\ub294 \uac83\uc774\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p>\uc81c4\uc7a5 \ud558\uc774\ube0c\ub9ac\ub3c4\ub9c8(hybridoma,\uc735\ud569\uc138\ud3ec)\uc758 \uc81c\uc870\uc6d0\ub9ac\uc5d0 \ub300\ud558\uc5ec<\/p>\n<p>\uac00. B \uc138\ud3ec\uc640 \uc554\uc138\ud3ec\uc758 \uc735\ud569<\/p>\n<p>(1) 1984\ub144 \ub178\ubca8\uc0dd\ub9ac\uc758\ud559\uc0c1\uc740 \uba74\uc5ed\uc2dc\uc2a4\ud15c\uc758 \ud56d\uccb4\uc81c\uc870\uc5f0\uad6c\uc758 \uc5c5\uc801\uc744 \uc138\uc6b4 \uc601\uad6d \uc138\uc790\ub974 -\ubc00\uc2a4\ud0c0\uc778 \ubc15\uc0ac\uac00 \uc218\uc0c1\ud558\uc600\ub2e4. \ubc00\uc2a4\ud0c0\uc778 \ubc15\uc0ac\ub294 \uc2dc\ud5d8\uad00(in vitro)\uc5d0\uc11c \uc7a5\uae30 \ubc30\uc591\uc774 \ubd88\uac00\ub2a5\ud55c \ud56d\uccb4\uc0dd\uc0b0\uc138\ud3ec(B \uc138\ud3ec)\uc640 \uace8\uc218\uc885\uc138\ud3ec(\uc885\uc591\uc138\ud3ec\/\uc554\uc138\ud3ec\/\ubbf8\uc5d0\ub85c\ub9c8 \uc138\ud3ec)\ub97c \uc735\ud569\uc2dc\ud0a4\uba74 \ud2b9\uc774\ud56d\uccb4\ub97c \ubc18\uc601\uad6c\uc801\uc73c\ub85c \uc2dc\ud5d8\uad00\ub0b4\uc5d0\uc11c \uc0dd\uc0b0\uac00\ub2a5\ud55c \uc0c8\ub85c\uc6b4 \uc885\uc591\uc138\ud3ec(\uc735\ud569\uc138\ud3ec)\uac00 \ub9cc\ub4e4\uc5b4\uc9c4\ub2e4\ub294 \uac83\uc744 \uc2e4\ud5d8\uc73c\ub85c \uc99d\uba85\ud558\uc600\ub2e4.<\/p>\n<p>(2) \uc678\ubd80\uc5d0\uc11c \uce68\uc785\ud558\ub294 \ud56d\uc6d0\uc758 \uc131\uc0c1\uc774 \uc815\ud574\uc9c4 \uac83\uc774 \uc544\ub2c8\ub77c \uc5b8\uc81c\ub098 \uc608\uce21\uc774 \ubd88\uac00\ub2a5\ud558\ub2e4. \ub9c9\uc0c1 \ud56d\uc6d0\uc774 \uba74\uc5ed\uacc4\uc5d0 \ub4e4\uc5b4\uc624\uba74 \ube44\ub85c\uc18c \uadf8 \ud56d\uc6d0\uc744 \uc778\uc2dd\ud558\uace0 \uba74\uc5ed\uacc4\ub294 \uadf8 \ud56d\uc6d0\uacfc \uacb0\ud569\ud560 \uc218 \uc788\ub294 \ud2b9\uc774\uc801 \uc218\uc6a9\uccb4\ub97c \uac00\uc9c4 \uc138\ud3ec\ub9cc \uc99d\uc2dd\ud558\uac8c \ub41c\ub2e4. \uc989 \ud558\ub098\uc758 B \uc138\ud3ec\ub294 \uc5b8\uc81c\ub098 \ud55c \uc885\ub958\uc758 \ud2b9\uc774\ud56d\uccb4\ub9cc \uc0dd\uc0b0\ud55c\ub2e4.\u00a0 \uc774\uc5d0 \ub300\ud558\uc5ec \uc735\ud569\uc138\ud3ec\ub294 \uc815\uc0c1 B\uc138\ud3ec\uc758 \uc131\uc0c1\uacfc \uc554\uc138\ud3ec\uc758 \ud2b9\uc131\uc744 \ubaa8\ub450 \uac00\uc9c4 \uac83\uc73c\ub85c \uc5b8\uc81c\ub098 \ud558\ub098\uc758 \ud56d\uc6d0\uacb0\uc815\uae30\uc640 \uacb0\ud569\ud558\ub294 \ub300\ub7c9\uc758 \ud56d\uccb4\ub97c \uc0dd\uc0b0\ud560 \uc218 \uc788\ub2e4.<\/p>\n<p>(3) \ud558\ub098\uc758 \ud56d\uc6d0\uacb0\uc815\uae30\uc640 \uacb0\ud569\uc774 \uac00\ub2a5\ud55c \ud56d\uccb4\ub97c \ub2e8\uc77c\ud2b9\uc774\uc801 \ud56d\uccb4\ub77c\uace0 \uc774\ub97c \ubaa8\ub178\ud074\ub85c\ub110 \ud56d\uccb4\ub77c\uace0 \ubd80\ub978\ub2e4. \uae30\uc874\uc758 \ud56d\uccb4\ub97c \uc81c\uc791\ud558\ub294 \ubc29\ubc95\uc740 \ub3d9\ubb3c\uc5d0 \ud56d\uc6d0\uc744 \uc8fc\uc785\ud558\uc5ec \ud608\uccad\uc744 \uc5bb\uc5b4\uc11c \uc774\ub97c \uc778\uccb4\uc5d0 \uc8fc\uc785\ud558\ub294 \ubc29\uc2dd\uc774\uc5c8\ub2e4. \ud558\uc9c0\ub9cc \ub3d9\ubb3c\ud56d\uccad\uc758 \uacbd\uc6b0 \ud56d\uc6d0\uc758 \uad6c\uc870\uac00 \ub2e4\uc218\uc758 \ud56d\uc6d0\uacb0\uc815\uae30\ub97c \uac00\uc9c0\ubbc0\ub85c\u00a0 \uc774\uc5d0 \ub300\uc751\ud558\ub294 \ud3f4\ub9ac\ud06c\ub85c\ub110 \ud56d\uccb4\uac00 \ub9cc\ub4e4\uc5b4\uc84c\ub2e4. \uc774\uc5d0 \ud3f4\ub9ac\ud074\ub85c\ub110 \ud56d\uccb4\ub294 \uc5b8\uc81c\ub098 \ub2e4\uc218\uc758 \ud56d\uc6d0\uacb0\uc815\uae30\ub97c \uac00\uc9c4 \ud56d\uc6d0\uc5d0 \ub300\ud558\uc5ec \uba74\uc5ed\ubc18\uc751\ud558\uac8c \ub418\ubbc0\ub85c \ud56d\uc6d0\uc5d0 \ub300\ud55c \ud45c\uc801\uacf5\uaca9\uc774 \uc0c1\ub300\uc801\uc73c\ub85c \ubbf8\ud761\ud558\uc600\ub2e4 \uc774\uc5d0 \ubc18\ud558\uc5ec \uc735\ud569\uc138\ud3ec\uc5d0 \uc758\ud558\uc5ec \uc81c\uc791\ud55c \ubaa8\ubaa8\ud074\ub85c\ub110 \ud56d\uccb4\ub294 \uccb4\ub0b4 \uce68\ud22c\ud55c \uc5b4\ub5a4 \ud56d\uc6d0\uc774\ub77c\ub3c4 \ud558\ub098\uc758 \ud56d\uc6d0\uacb0\uc815\uae30\ub9cc \uc11c\ub85c \ub9de\uc73c\uba74 \ubc14\ub85c \uacb0\ud569\ubc18\uc751\uc744 \uc77c\uc73c\ucf1c \ud56d\uc6d0\uc744 \ubb34\ub825\ud654\uc2dc\ud0a4\ubbc0\ub85c \uacf5\uaca9\uc758 \uc815\ud655\ub3c4\uac00 \uae30\uc874 \ubcf4\ub2e4 \ub9e4\uc6b0 \ud5a5\uc0c1\ub41c \ud56d\uccb4\uc774\ub2e4. \uc774\ub97c \ubbf8\uc0ac\uc77c \ud56d\uccb4\ub77c\uace0 \ubd80\ub974\ub294 \uc774\uc720\uac00 \ubc14\ub85c \uc5ec\uae30\uc5d0 \uc788\ub2e4.<\/p>\n<p>\ub098. HAT \ubc30\uc591\uacfc \uc735\ud569\uc138\ud3ec\uc758 \ud0c4\uc0dd<\/p>\n<p>\uc99d\uc2dd\uc131\uc774 \uc5c6\uace0 \ud2b9\uc815\ud56d\uc6d0\uc5d0 \ubc18\uc751\uc131\uc744 \uac00\uc9c4 B \uc138\ud3ec\uc640 \uc99d\uc2dd\uc131\uc740 \uc788\uc73c\ub098 \ud56d\uccb4 \ud56d\uc131\uc774 \uc548\ub418\ub294 \ubcc0\uc774\uc131 \uace8\uc218\uc131\uc138\ud3ec(\ubbf8\uc5d0\ub85c\ub9c8 \uc138\ud3ec)\ub97c \ud3f4\ub9ac\uc5d0\ud2f8\ub80c \uae00\ub9ac\ucf5c\uc744 \uc0ac\uc6a9\ud558\uc5ec \uc735\ud569\uc2dc\ucf1c \ud2b9\uc815\ud56d\uc6d0\uc5d0 \ubc18\uc751\ud558\ub294 \ud56d\uccb4\ub97c \ubb34\ud55c\ud788 \uc81c\uc870\ud558\ub294 \uae30\uc220\uc774 \ubc14\ub85c \uc138\ud3ec\uc735\ud569\uae30\uc220\uc774\ub2e4. \uc735\ud569\uc138\ud3ec\uc640 \ube44\uc735\ud569\uc138\ud3ec\uac00 \ud63c\uc7ac\ud558\ub294 \uc0c1\ud0dc\uc5d0\uc11c \uc758\ub3c4\ud558\ub294 \ud56d\uccb4\ub97c \uc0dd\uc0b0\ud558\ub294 \uc735\ud569\uc138\ud3ec(hybridoma)\uc758 \uc99d\uc2dd\uc740 \ubd88\uac00\ub2a5\ud558\ub2e4. \uc774\uc5d0 \ud558\uc774\ud37c\ud150\uc2e0, \uc544\ubbf8\ub178\ud14c\ub9b0, \ud2f0\ubbf8\ub518\uc774 \ud63c\ud569\ub41c \ubc30\uc591\uc561\uc5d0\uc11c \uc735\ud569\uc138\ud3ec\ub97c \ubc30\uc591\ud558\uba74\u00a0Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)\ub97c \uc815\uc0c1\uc801\uc778 B \uc138\ud3ec\ub85c\ubd80\ud130 \uc5bb\uc740 \uc735\ud569\uc138\ud3ec\ub294 HAT\ubc30\uc9c0\uc5d0\uc11c \uc99d\uc2dd\uc774 \uac00\ub2a5\ud558\uac8c\ub41c\ub2e4.\u00a0 HGPRT\ub294\u00a0 HPRT1 \uc720\uc804\uc790\uac00 \ud569\uc131\ud558\ub294 \ud6a8\uc18c\ub2e8\ubc31\uc9c8\ub85c\uc11c \ud4e8\ub9b0 \uc5fc\uae30 \ub274\ud074\ub808\uc624\uc624\ud2f0\ub4dc \ud569\uc131\uc5d0 \uc911\uc2ec\uc801\uc778 \uc5ed\ud560\uc744 \uc218\ud589\ud55c\ub2e4.(the purine salvage pathway.)<\/p>\n<p>&nbsp;<\/p>\n<p>\uc81c5\uc7a5 \ubaa8\ub178\ud074\ub85c\ub110 \ud56d\uccb4\uc758 \uc554\uce58\ub8cc \uc751\uc6a9<\/p>\n<p>(1) \uc9c0\uae08 \uc138\uacc4 \uac01\uad6d\uc5d0\uc11c\ub294 \uc0ac\ub78c\uc758 \ud3d0\uc554, \ub300\uc7a5\uc554, \uc704\uc554\ub4f1 \uac01\uac01 \uc554\uc744 \ud2b9\uc774\uc801\uc73c\ub85c \uc778\uc2dd\ud558\ub294 \ubaa8\ub178\ud074\ub85c\ub110 \ud56d\uccb4\uc758 \uac1c\ubc1c\uc774 \uc9c4\ud589\ub418\uace0 \uc788\ub2e4. \uc885\uc591\uc138\ud3ec \uc989 \uc554\uc138\ud3ec\uc758 \uc138\ud3ec\ub9c9 \ud45c\uba74\uc758 \ub2e8\ubc31\uc9c8 \uad6c\uc870 \uc77c\ubd80 \ubd80\uc704\ub97c \ud2b9\uc774\uc801\uc73c\ub85c \uc778\uc2dd\ud558\ub294 \ubaa8\ub178\uc624\ud074\ub85c\ub110 \ud56d\uccb4\ub97c \uc81c\uc791\ud558\uc5ec \uc778\uccb4 \ud22c\uc785\ud558\uba74 \ud56d\uccb4\ub294 \uc554\uc138\ud3ec\uc758 \uc138\ud3ec\ub9c9\uc758 \ud2b9\uc815 \ubd80\uc704\uc640 \uacb0\ud569\uc744 \uc2dc\ub3c4\ud558\uc5ec \uadf8 \uc554\uc138\ud3ec\ub97c \ubc15\uba78\ud558\uac8c \ub418\ub294 \uac83\uc774\ub2e4. \ud1b5\uc0c1 \uc554\uc138\ud3ec\ub294 \uc815\uc0c1 \uc138\ud3ec\ubcf4\ub2e4 \uc99d\uc2dd\uc18d\ub3c4\uac00 \ube60\ub974\uace0 \uc8fc\ubcc0\uc870\uc9c1\uc73c\ub85c \uce68\ud22c\ud558\ub294 \ubb34\uc11c\uc6b4 \ub3cc\ud30c\ub825\uc744 \uac00\uc9c0\uace0 \uc788\ub294 \ubc14, \uc554\uc138\ud3ec\uc758\uc138\ud3ec\ub9c9\uc758 \ub2f9\uace0\ub9ac \ud568\uc720\ub7c9\uc740 \uc815\uc0c1\uc138\ud3ec\ubcf4\ub2e4 \ub354 \ub9ce\uc544\uc11c \uc774 \uc911 \ud558\ub098\uc758 \ubd80\uc704\ub9cc \uc778\uc2dd\ud558\ub294 \ubaa8\ub178\ud074\ub85c\ub110 \ud56d\uccb4\ub97c \uc81c\uc791\ud558\uba74 \uc5b4\ub9c8\ub4e0\uc9c0 \uc554\uc138\ud3ec\ub97c \uacf5\uaca9\ud560 \uc218 \uc788\ub294 \uac83\uc774\ub2e4.<\/p>\n<p>(2) \uc735\ud569\uc138\ud3ec\uc5d0 \uc758\ud558\uc5ec \ub9cc\ub4e4\uc5b4\uc9c0\ub294 \ubaa8\ub178\ud074\ub85c\ub110 \ud56d\uccb4\ub294 \uc554\uc9c4\ub2e8\uc6a9\uc73c\ub85c \uac01\uad11\uc744 \ubc1b\uace0 \uc788\ub2e4. \ub2e4\ub978 \uc9c4\ub2e8\uc2dc\uc57d\uc758 \uacbd\uc6b0 \uc815\uc0c1 \uc138\ud3ec\ub97c \uacf5\uaca9\ud558\ub294 \ubd80\uc791\uc6a9\uc774 \uc2ec\ud558\uc600\uc9c0\ub9cc \ubaa8\ub178\ud074\ub85c\ub110 \ud56d\uccb4\uc758 \uacbd\uc6b0 \uc554\uc138\ud3ec\uc758 \ud2b9\uc774\uc801 \ubd80\uc704\ub9cc \uc815\ud655\ud558\uac8c \uc778\uc0ad\ud558\uc5ec \uacb0\ud569\ud558\ub294 \uc7a5\uc810\uc744 \uac00\uc9c0\uace0 \uc788\ub2e4. \ubaa8\ub178\ud074\ub85c\ub110 \ud56d\uccb4\ub294 \uc778\uccb4\uc5d0 \ub4e4\uc5b4\uac00\uc11c \uc554\uc138\ud3ec\ub97c \uc218\uc0c9\ud558\uc5ec \uc554\uc138\ud3ec\uc758 \ud2b9\uc774\uc801 \ud56d\uc6d0\ubd80\uc704\ub97c \uc778\uc2dd\ud558\uc5ec \uacb0\ud569\ud558\ub294 \ub2a5\ub825\uc744 \uac00\uc9c0\ubbc0\ub85c \uc2a4\ucee4\ub4dc \ubbf8\uc0ac\uc77c\uc5d0 \ube44\uc720\ub41c\ub2e4. \uadf8\ub7ec\ub098, \ubaa8\ub178\ud074\ub85c\ub110 \ud56d\uccb4\ub294 \uc778\uccb4\uc5d0 \uc8fc\uc785\ud558\uba74 \uc5b8\uc81c\ub098 \uc720\ud6a8\ud55c \uac83\uc774 \uc544\ub2c8\ub77c \uc9c0\uc18d\uc801\uc73c\ub85c \ud22c\uc785\ud558\uc5ec\uc57c \ud55c\ub2e4. \ud604\uc7ac\uc758 \uc5f0\uad6c \uc218\uc900\uc73c\ub85c\ub294 \uc554\uc138\ud3ec\ub97c \uacf5\uaca9\ud558\uc5ec \ubc15\uba78\ud55c\ub2e4\uace0 \ud558\uc5ec\ub3c4 \uc554\uc138\ud3ec\ub97c 100% \uc8fd\uc774\ub294 \uac83\uc774 \uc544\ub2c8\ub77c\uc11c \uad81\uadf9\uc801\uc778 \uc554\uce58\ub8cc \uc218\ub2e8\uc774 \uc544\ub2c8\ub77c \ubcf4\uc870\uc218\ub2e8 \ub0b4\uc9c0 \uc554\uc9c4\ub2e8\uc6a9\uc73c\ub85c \uc0ac\uc6a9\ub418\uace0 \uc788\ub2e4\ub294 \uc810\uc774 \uadf8 \ud55c\uacc4\uc774\ub2e4.<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\uc544\ub798\ub294 2021\ub144 7\uc6d4 6\uc77c \ub274\uc2a4\uc785\ub2c8\ub2e4~<\/p>\n<p>(\uc6d0\ubb38: <a href=\"https:\/\/n.news.naver.com\/mnews\/article\/584\/0000014982\">\uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n<p>&nbsp;<\/p>\n<div class=\"media_end_head go_trans\">\n<div class=\"media_end_head_title\">\n<h2 id=\"title_area\" class=\"media_end_head_headline\">\ud56d\uccb4\uce58\ub8cc\uc81c \uc804\uc131\uc2dc\ub300 \uc5f4\ub9ac\ub098<\/h2>\n<\/div>\n<div class=\"media_end_head_info nv_notrans \">\n<div class=\"media_end_head_info_datestamp\"><\/div>\n<div class=\"media_end_head_info_variety\">\n<div class=\"media_end_head_info_variety_right\">\n<div class=\"media_end_head_print\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"contents\" class=\"newsct_body\">\n<div id=\"newsct_article\" class=\"newsct_article _article_body\">\n<div id=\"dic_area\" class=\"go_trans _article_content\">\n<div class=\"pic_c\">\n<div class=\"nbd_im_w _LAZY_LOADING_WRAP \">\n<div id=\"img_a1\" class=\"nbd_a _LAZY_LOADING_ERROR_HIDE\"><img decoding=\"async\" id=\"img1\" class=\"_LAZY_LOADING\" src=\"https:\/\/imgnews.pstatic.net\/image\/584\/2021\/07\/06\/0000014982_001_20210706173213051.jpg?type=w647\" \/><\/div>\n<\/div>\n<p><span class=\"end_photo_org\"><em class=\"img_desc\">2014\ub144 \ud751\uc0c9\uc885 \uce58\ub8cc\uc81c\ub85c\u00a0<span data-type=\"ore\" data-lang=\"en\">FDA<\/span>\uac00 \uc2b9\uc778\ud55c \ud0a4\ud2b8\ub8e8\ub2e4\ub294 \uadf8\ub4a4 \ud3d0\uc554 \uce58\ub8cc\uc81c\ub85c \uc801\uc6a9\uc774 \ud655\ub300\ub418\uba74\uc11c \ubcf8\uaca9\uc801\uc778 \uba74\uc5ed\ud56d\uc554\uc81c \uc2dc\ub300\ub97c \uc5f0 \ud56d\uccb4\uce58\ub8cc\uc81c\ub2e4. \uad6d\ub0b4\uc5d0\uc11c\ub294 2017\ub144 \uc0ac\uc6a9\uc774 \uc2b9\uc778\ub410\uc9c0\ub9cc \uc544\uc9c1 \ud3d0\uc554 1\ucc28 \uce58\ub8cc\uc5d0\uc11c\ub294 \uac74\ubcf4 \uc801\uc6a9\uc774 \uc548 \ub418\uace0 \uc788\ub2e4. \uba38\ud06c \uc0e4\ud504 \uc564 \ub3d4 \uc81c\uacf5<\/em><\/span><\/div>\n<\/div>\n<div><\/div>\n<div><\/div>\n<div class=\"go_trans _article_content\">\uc9c0\ub09c\ud574 \uc2e0\ubb38\uc5d0 \uc2e4\ub9b0 \ud55c \uae30\uace0\ubb38\uc744 \uc77d\uace0 \uc758\ub8cc \ud604\uc2e4\uc758 \ube44\uc815\ud568\uc5d0 \ucda9\uaca9\uc744 \ubc1b\uc740 \uc801\uc774 \uc788\ub2e4. \ud55c\uad6d\ud3d0\uc554\ud658\uc6b0\ud68c \uc774\uac74\uc8fc \ud68c\uc7a5\uc774 \uc4f4 \uae00\ub85c, \ud3d0\uc554 \uba74\uc5ed\ud56d\uc554\uc81c\uc758 \uac74\uac15\ubcf4\ud5d8 \uc801\uc6a9 \ud655\ub300\ub97c \ucd09\uad6c\ud558\ub294 \ub0b4\uc6a9\uc774\ub2e4. \ub2f9\uc2dc \uc815\ubd80\uac00 \ucf54\ub85c\ub098\ub85c \uc9c0\uce5c \uad6d\ubbfc\ub4e4\uc5d0\uac8c \ud1b5\uc2e0\ube44 2\ub9cc \uc6d0\uc744 \uc9c0\uc6d0\ud55c\ub2e4\ub294 \uc548\uc744 \ub0b4\ub193\uc790 \uc2e4\ud6a8\uc131 \ub17c\ub780\uc774 \uc77c\ub358 \uc0c1\ud669\uc5d0\uc11c \uc774 \ud68c\uc7a5\uc740 \u201c\ud5c8\uac00\uac00 \ub09c\uc9c0 3\ub144\uc774 \uc9c0\ub0ac\uc9c0\ub9cc \uc5ec\uc804\ud788 2\ucc28 \uce58\ub8cc \ub2e8\uacc4\uc5d0\uc11c\ub9cc \uac74\ubcf4 \uc801\uc6a9\uc774 \uac00\ub2a5\ud558\ub2e4\u201d\uba70 \u201c\ud1b5\uc2e0\uc9c0\uc6d0\ube44\uc758 \uc808\ubc18\uc774\uba74 1\ucc28 \uce58\ub8cc\ubd80\ud130 \uc801\uc6a9\ud560 \uc218 \uc788\ub2e4\u201d\uace0 \ud638\uc18c\ud588\ub2e4.<\/p>\n<p>\ud6a8\uacfc\uac00 \ud06c\uace0 \ubd80\uc791\uc6a9\uc774 \uc791\uc740 \uba74\uc5ed\ud56d\uc554\uc81c\uac00 \uc788\uc74c\uc5d0\ub3c4 \ud604\uc7ac 4\uae30 \ud3d0\uc554 \ud658\uc790\uc758 1\ucc28 \uce58\ub8cc\ub294 \uae30\uc874 \ud56d\uc554\uc81c\ub9cc \uc368\uc57c \ud558\uace0 \uc774\uac8c \ud6a8\uacfc\uac00 \uc5c6\ub2e4\ub294 \uac78 \uc785\uc99d\ud55c \ub4a4\uc5d0\uc57c 2\ucc28 \uce58\ub8cc\ub85c \uba74\uc5ed\ud56d\uc554\uc81c\ub97c \uc4f8 \uc218 \uc788\ub2e4.<\/p>\n<p>\uc548\ud0c0\uae5d\uac8c\ub3c4 \ud658\uc790 10\uba85 \uac00\uc6b4\ub370 6\uba85\uc740 1\ucc28 \uce58\ub8cc\ub97c \ubc1b\ub2e4\uac00 \uc0ac\ub9dd\ud558\uac70\ub098 \uc911\ub3c4\uc5d0 \ud3ec\uae30\ud55c\ub2e4. \ud3d0\uc554 \ud658\uc790\uac00 \ucc98\uc74c\ubd80\ud130 \uba74\uc5ed\ud56d\uc554\uc81c\ub97c \uc4f0\uba74 \uac74\ubcf4 \uc801\uc6a9\uc774 \uc548 \ub3fc \uce58\ub8cc\ube44\uac00 1\ub144\uc5d0 1\uc5b5 \uc6d0 \uac00\uae4c\uc774 \ub4e0\ub2e4. \uc774 \ud68c\uc7a5\uc740 \ub2e4\ud589\ud788 \ud5c8\uac00 \uc774\uc804 \uc784\uc0c1\uc2dc\ud5d8\uc5d0 \ucc38\uc5ec\ud574 \ubb34\ub8cc\ub85c \uce58\ub8cc\ub97c \ubc1b\uc744 \uc218 \uc788\uc5c8\ub2e4. \ub2f9\uc2dc \ud1b5\uc2e0\uc9c0\uc6d0\ube44\ub294 \uc5c6\ub358 \uc598\uae30\uac00 \ub410\uc9c0\ub9cc \uadf8\ub807\ub2e4\uace0 \uac74\ubcf4 \uc801\uc6a9\uc774 \ud655\ub300\ub418\uc9c0\ub294 \uc54a\uc558\ub2e4. \uc774 \ud68c\uc7a5\uc774 \ub9d0\ud558\ub294 \ud3d0\uc554 \uba74\uc5ed\ud56d\uc554\uc81c\ub294 \u2018\uae30\uc801\uc758 \uc2e0\uc57d\u2019\uc73c\ub85c \ubd88\ub9ac\ub294 \ud3a8\ube0c\ub85c\ub9ac\uc8fc\ub9d9(\uc81c\ud488\uba85 \ud0a4\ud2b8\ub8e8\ub2e4)\uc774\ub2e4.<\/p>\n<div>\u25cb36\ub144 \ub9cc\uc5d0 100\uac1c \uc2b9\uc778<\/div>\n<div><\/div>\n<div class=\"pic_c\">\n<div class=\"nbd_im_w _LAZY_LOADING_WRAP \">\n<div id=\"img_a2\" class=\"nbd_a _LAZY_LOADING_ERROR_HIDE\"><img decoding=\"async\" id=\"img2\" class=\"_LAZY_LOADING\" src=\"https:\/\/imgnews.pstatic.net\/image\/584\/2021\/07\/06\/0000014982_002_20210706173213075.jpg?type=w647\" \/><\/div>\n<\/div>\n<p><span class=\"end_photo_org\"><em class=\"img_desc\">1986\ub144 \ubbf8\uad6d\uc2dd\ud488\uc758\uc57d\uad6d(<span data-type=\"ore\" data-lang=\"en\">FDA<\/span>)\uc774 \ucc98\uc74c \ud56d\uccb4\uce58\ub8cc\uc81c\ub97c \uc2b9\uc778\ud55c \uc774\ub798 10\ubc88\uc9f8 \uc2e0\uc57d\uc774 \ub098\uc62c \ub54c\uac00\uc9c0 15\ub144, 50\ubc88\uc9f8 \uc2e0\uc57d\uc774 \ub098\uc62c \ub54c\uae4c\uc9c0 29\ub144\uc774 \uac78\ub838\ub2e4. \uadf8\ub4a4 \ubd88\uacfc 5\ub144 4\uac1c\uc6d4 \ub9cc\uc5d0 50\uac1c\uac00 \ucd94\uac00\ub3fc \uc9c0\ub09c 4\uc6d4 100\ubc88\uc9f8 \ud56d\uccb4\uce58\ub8cc\uc81c\uac00 \uc2b9\uc778\ub410\ub2e4. \ub124\uc774\ucc98 \ub9ac\ubdf0\uc2a4 \uc57d\ubb3c \uac1c\ubc1c \uc81c\uacf5<\/em><\/span><\/div>\n<\/div>\n<div><\/div>\n<div><\/div>\n<div class=\"go_trans _article_content\">\uc774\ub7f0 \ubd88\ub9ac\ud55c \uc870\uac74\uc5d0\ub3c4 \ud0a4\ud2b8\ub8e8\ub2e4\ub294 \uc9c0\ub09c 1\ubd84\uae30 \uad6d\ub0b4 \uc758\uc57d\ud488 \ub9e4\ucd9c 1\uc704\uc5d0 \uc62c\ub790\ub2e4. \ub9e4\ucd9c 3\uc704\ub294 \uac04\uc554\uacfc \ub300\uc7a5\uc554 \ud45c\uc801\ud56d\uc554\uc81c\uc778 \ubca0\ubc14\uc2dc\uc8fc\ub9d9(\uc81c\ud488\uba85 \uc544\ubc14\uc2a4\ud2f4)\uc774\uace0 \ub9e4\ucd9c 4\uc704\ub294 \uc790\uac00\uba74\uc5ed\uc9c8\ud658 \uce58\ub8cc\uc81c\uc778 \uc544\ub2ec\ub9ac\ubb34\ub9d9(\uc81c\ud488\uba85 \ud734\ubbf8\ub77c)\ub2e4. \uc774\ub4e4 \uc81c\ud488\uc740 \ubaa8\ub450 \ud56d\uccb4\uce58\ub8cc\uc81c\uc5d0 \uc18d\ud55c\ub2e4. \ubc14\uc57c\ud750\ub85c \ud56d\uccb4\uce58\ub8cc\uc81c\uac00 \uc758\uc57d\ud488\uc758 \uc8fc\ub958\ub85c \ub5a0\uc624\ub974\uace0 \uc788\ub2e4.<\/p>\n<p>\uad6d\uc81c\ud559\uc220\uc9c0 \u2018\ub124\uc774\ucc98 \ub9ac\ubdf0\uc2a4 \uc57d\ubb3c \ubc1c\uacac\u2019 7\uc6d4\ud638\uc5d0\ub294 \uc9c0\ub09c 4\uc6d4 \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(<span data-type=\"ore\" data-lang=\"en\">FDA<\/span>)\uc774 100\ubc88\uc9f8 \ud56d\uccb4\uce58\ub8cc\uc81c\ub97c \uc2b9\uc778\ud55c \uac78 \uacc4\uae30\ub85c \ud56d\uccb4\uce58\ub8cc\uc81c\uc758 \uacfc\uac70\uc640 \ud604\uc7ac\ub97c \uc815\ub9ac\ud558\uace0 \ubbf8\ub798\ub97c \uc870\ub9dd\ud558\ub294 \uc7a5\ubb38\uc758 \uae30\uc0ac\uac00 \uc2e4\ub838\ub2e4. \uc774\uc5d0 \ub530\ub974\uba74 2019\ub144 \uc138\uacc4 \uc758\uc57d\ud488 \ub9e4\ucd9c \uc0c1\uc704 20\uac1c \uac00\uc6b4\ub370 9\uac1c\uac00 \ud56d\uccb4\uce58\ub8cc\uc81c\ub85c \uc774\ub4e4\uc758 \ub9e4\ucd9c\uc561\uc744 \ud569\uce58\uba74 \ubb34\ub824 750\uc5b5 \ub2ec\ub7ec(\uc57d 85\uc870 \uc6d0)\uc5d0 \uc774\ub978\ub2e4. \ud56d\uccb4\uce58\ub8cc\uc81c \uac00\uc6b4\ub370 1\uc704\ub294 \ud734\ubbf8\ub77c(\uad6d\ub0b4 4\uc704)\ub85c \ub9e4\ucd9c\uc561\uc774 196\uc5b5 \ub2ec\ub7ec\uc5d0 \uc774\ub974\uace0 \ud0a4\ud2b8\ub8e8\ub2e4\uac00 111\uc5b5 \ub2ec\ub7ec\ub85c 2\uc704\ub2e4.<\/p>\n<p>\ud754\ud788 \ud56d\uccb4\uce58\ub8cc\uc81c\ub77c\uace0 \ubd88\ub9ac\ub294 \ub2e8\uc77c\ud074\ub860\ud56d\uccb4 \uc57d\ubb3c\uc740 1986\ub144 \ucc98\uc74c\u00a0<span data-type=\"ore\" data-lang=\"en\">FDA<\/span>\uc758 \uc2b9\uc778\uc744 \ubc1b\uace0 \uc2dc\uc7a5\uc5d0 \ub098\uc654\ub2e4. \uc7a5\uae30\uc774\uc2dd\uac70\ubd80\ubc18\uc751\uc744 \uc904\uc774\ub294 \uba74\uc5ed\uc5b5\uc81c\uc81c \ubba4\ub85c\ubaa8\ub0a9<span data-type=\"ore\" data-lang=\"en\">-CD3<\/span>(\uc81c\ud488\uba85 \uc624\ub974\ud1a0\ud074\ub860\u00a0<span data-type=\"ore\" data-lang=\"en\">OKT3<\/span>)\ub85c, \uba74\uc5ed\uacc4\uc758 T\uc138\ud3ec\uc758 \ud45c\uba74\uc5d0 \uc788\ub294\u00a0<span data-type=\"ore\" data-lang=\"en\">CD3<\/span>\u00a0\ub2e8\ubc31\uc9c8\uc744 \ud56d\uc6d0(\ud45c\uc801)\uc73c\ub85c \ud558\ub294 \ud56d\uccb4\uce58\ub8cc\uc81c\ub2e4. T\uc138\ud3ec \ud45c\uba74\uc5d0 \uc624\ub974\ud1a0\ud074\ub860\u00a0<span data-type=\"ore\" data-lang=\"en\">OKT3<\/span>\uac00 \ub2ec\ub77c\ubd99\uc5b4 \uc791\uc6a9\uc744 \ubc29\ud574\ud574 \uac70\ubd80\ubc18\uc751\uc744 \uc57d\ud654\uc2dc\ud0a8\ub2e4.<\/p>\n<p>\uadf8\ub85c\ubd80\ud130 8\ub144\uc774 \uc9c0\ub09c 1994\ub144\uc5d0\uc57c \ub450 \ubc88\uc9f8 \ud56d\uccb4\uce58\ub8cc\uc81c \uc555\uc2dd\uc2dc\ub9d9(\uc81c\ud488\uba85 \ub808\uc624\ud504\ub85c)\uac00 \uc2b9\uc778\ub410\ub2e4. \ud608\uc18c\ud310 \uc751\uc9d1\uc5d0 \uad00\uc5ec\ud558\ub294 \ub2e8\ubc31\uc9c8\uc744 \ud56d\uc6d0\uc73c\ub85c \ud558\ub294 \ud56d\uccb4\ub85c \uad00\uc0c1\ub3d9\ub9e5\uc758 \ud608\uc804 \uc0dd\uc131\uc744 \uc5b5\uc81c\ud574 \uc2ec\uc7a5\uc9c8\ud658 \uc704\ud5d8\uc131\uc744 \ub0ae\ucd94\ub294 \uc57d\ubb3c\uc774\ub2e4. \ucc38\uace0\ub85c \uc774 \uc0ac\uc774 \ud56d\uccb4\uce58\ub8cc\uc81c\uc758 \uc131\ubd84\uba85 \ub05d\uc5d0 \ub2e8\uc77c\ud074\ub860\ud56d\uccb4(<span data-type=\"ore\" data-lang=\"en\">monoclonal<\/span>\u00a0<span data-type=\"ore\" data-lang=\"en\">antibody<\/span>)\uc758 \uc601\ubb38 \uc57d\uc790\uc778 \u2018<span data-type=\"ore\" data-lang=\"en\">mab<\/span>(\ub9d9)\u2019\uc744 \ubd99\uc774\uae30\ub85c \ud569\uc758\ud558\uba74\uc11c \uc774\ud6c4 \uc57d\ubb3c\ub4e4\uc740 \u2018\u3147\u3147\u3147\ub9d9\u2019\uc73c\ub85c \ubd88\ub9b0\ub2e4.<\/p>\n<p>\uc9c0\ub09c 2001\ub144 10\ubc88\uc9f8 \ud56d\uccb4\uce58\ub8cc\uc81c\uac00 \uc2b9\uc778\ub410\uace0 29\ub144 \ub9cc\uc778 2015\ub144 \ub9d0 50\uac1c\ub97c \ucc44\uc6e0\ub2e4. \uadf8\ub9ac\uace0 5\ub144 4\uac1c\uc6d4\uc774 \uc9c0\ub09c \uc62c\ud574 4\uc6d4 100\ubc88\uc9f8 \uba74\uc5ed\uce58\ub8cc\uc81c\ub85c \uc790\uad81\ub0b4\ub9c9\uc554 \ud56d\uc554\uc81c \ub3c4\uc2a4\ud0c8\ub9ac\ub9d9(\uc81c\ud488\uba85 \uc82c\ud384\ub9ac)\uac00 \uc2b9\uc778\ub410\ub2e4. \uadf8 \ub4a4 3\uac1c\uac00 \ucd94\uac00\ub410\ub294\ub370, \uc9c0\ub09c\ub2ec \uc2b9\uc778\ub41c 103\ubc88\uc9f8 \uc57d\ubb3c\uc774 \ud604\uc7ac \uc57d\ud6a8 \uc5ec\ubd80\ub85c \ub17c\ub780\uc774 \ub418\uace0 \uc788\ub294 \uc54c\uce20\ud558\uc774\uba38\ubcd1 \uce58\ub8cc\uc81c \uc544\ub450\uce74\ub204\ub9d9(\uc81c\ud488\uba85 \uc544\ub450\ud5ec\ub984)\uc73c\ub85c \uc544\ubc00\ub85c\uc774\ub4dc \ubca0\ud0c0 \ub2e8\ubc31\uc9c8\uc774 \ud56d\uc6d0(\ud45c\uc801)\uc774\ub2e4.<\/p>\n<div>\u25cb\ud56d\uc554\uc81c\uac00 \uac00\uc7a5 \ub9ce\uc544<\/div>\n<div><\/div>\n<div class=\"pic_c\">\n<div class=\"nbd_im_w _LAZY_LOADING_WRAP \">\n<div id=\"img_a3\" class=\"nbd_a _LAZY_LOADING_ERROR_HIDE\"><img decoding=\"async\" id=\"img3\" class=\"_LAZY_LOADING\" src=\"https:\/\/imgnews.pstatic.net\/image\/584\/2021\/07\/06\/0000014982_003_20210706173213091.jpg?type=w647\" \/><\/div>\n<\/div>\n<p><span class=\"end_photo_org\"><em class=\"img_desc\"><span data-type=\"ore\" data-lang=\"en\">FDA<\/span>\u00a0\uc2b9\uc778\uc744 \ubc1b\uc740 \ud56d\uccb4\uce58\ub8cc\uc81c 100\uc885\uc758 80%\ub294 \uc804\ud615\uc801\uc778 \ud615\ud0dc(\ub9e8 \uc67c\ucabd)\uc774\uc9c0\ub9cc \ub3c5\ud55c \uc57d\ubb3c\uacfc \uacb0\ud569\ub41c \ud615\ud0dc(<span data-type=\"ore\" data-lang=\"en\">antibody-drug<\/span>\u00a0<span data-type=\"ore\" data-lang=\"en\">conujugates<\/span>)(\ud45c\uc801 \ubd80\uc704\ub85c \uc57d\ubb3c\uc744 \ub370\ub824\uac00\ub294 \uc5ed\ud560\uc744 \ud55c\ub2e4)\uc640 \ub450 \uac00\uc9c0 \ud56d\uc6d0\uc744 \uc778\uc2dd\ud558\ub294 \ud615\ud0dc(<span data-type=\"ore\" data-lang=\"en\">bispecifics<\/span>), \ud56d\uc6d0 \uc778\uc2dd \ubd80\uc704\ub9cc \uc788\uc5b4 \ub369\uce58\uac00 \uc791\uc544 \uce68\ud22c\ub825\uc774 \ub192\uc740 \ud615\ud0dc(<span data-type=\"ore\" data-lang=\"en\">fragments<\/span>)\ub3c4 \uc788\ub2e4. \ub124\uc774\ucc98 \ub9ac\ubdf0\uc2a4 \uc57d\ubb3c \uac1c\ubc1c \uc81c\uacf5<\/em><\/span><\/div>\n<\/div>\n<div><\/div>\n<div><\/div>\n<div class=\"go_trans _article_content\">\ud56d\uccb4\uce58\ub8cc\uc81c 100\uac1c\uc758 \uba74\uba74\uc744 \ubcf4\uba74 \ub300\ub2e8\ud55c \uac8c \ub9ce\uc9c0\ub9cc \uadf8 \uac00\uc6b4\ub370\uc11c\ub3c4 \uba87 \uac00\uc9c0\ub294 \uc758\ud559\uc0ac\uc5d0 \ud070 \uc871\uc801\uc744 \ub0a8\uacbc\ub2e4\uace0 \ud3c9\uac00\ud560 \uc218 \uc788\ub2e4. 1997\ub144 \ub9bc\ud504\uc885 \uce58\ub8cc\uc81c\ub85c\u00a0<span data-type=\"ore\" data-lang=\"en\">FDA<\/span>\u00a0\uc2b9\uc778\uc774 \ub09c \ub9ac\ud22d\uc2dc\ub9d9(\uc81c\ud488\uba85 \ub9ac\ud22d\uc0b0)\uacfc 1998\ub144 \uc720\ubc29\uc554 \uce58\ub8cc\uc81c\ub85c \uc2b9\uc778\ub41c \ud2b8\ub77c\uc2a4\ud22c\uc8fc\ub9d9(\uc81c\ud488\uba85 \ud5c8\uc149\ud2f4)\uc740 2\uc138\ub300 \ud56d\uc554\uc81c\ub85c \ubd88\ub9ac\ub294 \ud45c\uc801\ud56d\uc554\uc81c \uc2dc\ub300\ub97c \uc5f0 \ube14\ub85d\ubc84\uc2a4\ud130 \ud56d\uccb4\uce58\ub8cc\uc81c\ub2e4.<\/p>\n<p>\ub9ac\ud22d\uc2dc\ub9d9\uc740 \uc554\uc138\ud3ec\uac00 \ub41c B\uc138\ud3ec \ud45c\uba74\uc758\u00a0<span data-type=\"ore\" data-lang=\"en\">CD20<\/span>\u00a0\ub2e8\ubc31\uc9c8\uc744 \ud56d\uc6d0(\ud45c\uc801)\uc73c\ub85c \ud558\uace0 \ud2b8\ub77c\uc2a4\ud22c\uc8fc\ub9d9\uc740 \uc720\ubc29\uc554 \uc138\ud3ec \ud45c\uba74\uc5d0 \ub9ce\uc740\u00a0<span data-type=\"ore\" data-lang=\"en\">HER2<\/span>\u00a0\ub2e8\ubc31\uc9c8\uc744 \ud56d\uc6d0\uc73c\ub85c \ud558\ub294 \ud56d\uccb4\ub85c \uc554\uc138\ud3ec\uc758 \uc99d\uc2dd\uc744 \ub9c9\uace0 \uba74\uc5ed\uc138\ud3ec\ub97c \ubd88\ub7ec\ub4e4\uc778\ub2e4. \uc218\ub9ce\uc740 \uc554\ud658\uc790\uc758 \ubaa9\uc228\uc744 \uad6c\ud55c \ub9ac\ud22d\uc2dc\ub9d9\uacfc \ud2b8\ub77c\uc2a4\ud22c\uc8fc\ub9d9\uc740 \uc9c0\uae08\ub3c4 \ud56d\uccb4\uce58\ub8cc\uc81c \uac00\uc6b4\ub370 \ub9e4\ucd9c\uc561 5\uc704\uc640 7\uc704\uc5d0 \uc62c\ub77c\uc788\ub2e4.<\/p>\n<p>1998\ub144 \ud06c\ub860\ubcd1 \uce58\ub8cc\uc81c\ub85c \uc2b9\uc778\ub41c \uc778\ud50c\ub9ad\uc2dc\ub9d9(\uc81c\ud488\uba85 \ub808\ubbf8\ucf00\uc774\ub4dc)\uacfc 2002\ub144 \ub958\uba38\ud2f0\uc2a4\uad00\uc808\uc5fc \uce58\ub8cc\uc81c\ub85c \uc2b9\uc778\uc774 \ub09c \uc544\ub2ec\ub9ac\ubb34\ub9d9(\uc81c\ud488\uba85 \ud734\ubbf8\ub77c)\uc740 \uc790\uac00\uba74\uc5ed\uc9c8\ud658 \ud56d\uccb4\uce58\ub8cc\uc81c\ub97c \ub300\ud45c\ud55c\ub2e4. \uc790\uac00\uba74\uc5ed\uc9c8\ud658\uc740 \uba74\uc5ed\uacc4\uac00 \uacfc\uc789 \ubc18\uc751\ud574 \uc790\uae30 \uc870\uc9c1\uc744 \uacf5\uaca9\ud55c \uacb0\uacfc\ub85c \uc774 \uacfc\uc815\uc5d0\u00a0<span data-type=\"ore\" data-lang=\"en\">TNF<\/span>(\uc885\uc591\uad34\uc0ac\uc778\uc790)\ub77c\ub294 \uc791\uc740 \ub2e8\ubc31\uc9c8\uc774 \uba74\uc5ed\uacc4\uc758 \uc138\ud3ec \uc2e0\ud638\ub97c \ub2f4\ub2f9\ud55c\ub2e4. \ub530\ub77c\uc11c\u00a0<span data-type=\"ore\" data-lang=\"en\">TNF<\/span>\ub97c \ud56d\uc6d0\uc73c\ub85c \ud558\ub294 \ud56d\uccb4\ub97c \ub9cc\ub4e4\uc5b4 \ub18d\ub3c4\ub97c \ub0ae\ucd94\uba74 \uc99d\uc0c1\uc744 \uc904\uc77c \uc218 \uc788\uc744 \uac83\uc774\ub2e4.<\/p>\n<p>\ub450 \uc57d\ubb3c\uc740 \uc608\uc0c1\ub300\ub85c \uc57d\ud6a8\uac00 \ub6f0\uc5b4\ub0ac\uace0 \uc2a4\ud14c\ub85c\uc774\ub4dc\ubc16\uc5d0 \uae30\ub308 \uac8c \uc5c6\ub358 \ud658\uc790\ub4e4\uc5d0\uac8c \uae30\uc801\uc758 \uc2e0\uc57d\uc73c\ub85c \ubc1b\uc544\ub4e4\uc5ec\uc84c\ub2e4. \uc778\ud50c\ub9ad\uc2dc\ub9d9\uc740 \uc5ec\uc804\ud788 \ud56d\uccb4\uce58\ub8cc\uc81c 8\uc704\uc5d0 \uc62c\ub77c\uc788\ub2e4. 4\ub144 \ub4a4 \ucd9c\uc2dc\ub41c \uc544\ub2ec\ub9ac\ubb34\ub9d9\uc740 \ud30c\uc9c0\ub514\uc2a4\ud50c\ub808\uc774\ub77c\ub294 \uc2e0\uae30\uc220\ub85c \ub9cc\ub4e0 \ud56d\uccb4\ub85c \uc57d\ud6a8\uac00 \ub354 \ub6f0\uc5b4\ub098\uace0 \ubd80\uc791\uc6a9\uc740 \ub354 \uc904\uc5c8\ub2e4. \uc774 \ubc29\ubc95\uc744 \uac1c\ubc1c\ud55c \uc5c5\uc801\uc73c\ub85c \uadf8\ub808\uace0\ub9ac \uc708\ud130\ub294 2018\ub144 \ub178\ubca8\ud654\ud559\uc0c1\uc744 \uc218\uc0c1\ud588\ub2e4. \uc120\uc9c4\uad6d\uc5d0\uc11c \uc790\uac00\uba74\uc5ed\uc9c8\ud658 \ud658\uc790\uac00 \uacc4\uc18d \ub290\ub294 \ucd94\uc138\ub77c \uc544\ub2ec\ub9ac\ubb34\ub9d9\uc740 \ud56d\uccb4\uce58\ub8cc\uc81c \uac00\uc6b4\ub370 \uc555\ub3c4\uc801\uc778 1\uc704\ub97c \ub2ec\ub9ac\uace0 \uc788\ub2e4.<\/p>\n<p>2014\ub144 \ud53c\ubd80\uc554\uc778 \ud751\uc0c9\uc885 \uce58\ub8cc\uc81c\ub85c \uc2b9\uc778\ub41c \ud3a8\ube0c\ub85c\ub9ac\uc8fc\ub9d9(\uc81c\ud488\uba85 \ud0a4\ud2b8\ub8e8\ub2e4)\uacfc \ub2c8\ubcfc\ub8e8\ub9d9(\uc81c\ud488\uba85 \uc635\ub514\ubcf4)\uc740 \ub458 \ub2e4 T\uc138\ud3ec \ud45c\uba74\uc758\u00a0<span data-type=\"ore\" data-lang=\"en\">PD-1<\/span>\u00a0\ub2e8\ubc31\uc9c8\uc744 \ud56d\uc6d0\uc73c\ub85c \ud558\ub294 \ud56d\uccb4\ub85c, 3\uc138\ub300 \ud56d\uc554\uc81c\ub85c \ubd88\ub9ac\ub294 \uba74\uc5ed\ud56d\uc554\uc81c \uc2dc\ub300\ub97c \ubcf8\uaca9\uc801\uc73c\ub85c \uc5f4\uc5c8\ub2e4.\u00a0<span data-type=\"ore\" data-lang=\"en\">PD-1<\/span>\u00a0\ub2e8\ubc31\uc9c8\uc744 \ud45c\uc801\uc73c\ub85c \ud568\uc5d0\ub3c4 \uc791\uc6a9 \uba54\ucee4\ub2c8\uc998\uc740 \ud45c\uc801\ud56d\uc554\uc81c\uc640 \uc804\ud600 \ub2e4\ub974\ub2e4.<\/p>\n<p>\uc554\uc138\ud3ec\ub294\u00a0<span data-type=\"ore\" data-lang=\"en\">PD-1<\/span>\uacfc \uacb0\ud569\ud574 T\uc138\ud3ec\uac00 \uc790\uc2e0\uc744 \uacf5\uaca9\ud558\uc9c0 \uc54a\uac8c \uc720\ub3c4\ud55c\ub2e4. \uc774\ub54c \ud56d\uccb4\uac00 \uba3c\uc800\u00a0<span data-type=\"ore\" data-lang=\"en\">PD-1<\/span>\uc5d0 \ub2ec\ub77c\ubd99\uc73c\uba74 \uc554\uc138\ud3ec\uac00 \uad50\ub780\uc791\uc804\uc744 \ud3bc \uc218 \uc5c6\uc5b4 T\uc138\ud3ec\uc758 \uacf5\uaca9\uc744 \ubc1b\ub294\ub2e4. \uc778\uccb4\uc758 \uba74\uc5ed\uacc4\ub97c \uae68\uc6cc \uc554\uc744 \uce58\ub8cc\ud558\ubbc0\ub85c \uba74\uc5ed\ud56d\uc554\uc81c\ub85c \ubd88\ub9b0\ub2e4. \ud56d\uccb4\uce58\ub8cc\uc81c \ub9e4\ucd9c\uc561 \uc21c\uc704\uc5d0\uc11c \ud3a8\ube0c\ub85c\ub9ac\uc8fc\ub9d9\uacfc \ub2c8\ubcfc\ub8e8\ub9d9\uc740 \uac01\uac01 2\uc704\uc640 3\uc704\uc5d0 \uc62c\ub77c\uc788\ub2e4. 1990\ub144\ub300 T\uc138\ud3ec\uc5d0\uc11c\u00a0<span data-type=\"ore\" data-lang=\"en\">PD-1<\/span>\uc744 \ubc1c\uacac\ud55c \ud63c\uc870 \ud0c0\uc2a4\ucfe0\ub294 \uc774 \uc5c5\uc801\uc73c\ub85c<br \/>\n2018\ub144 \ub178\ubca8\uc0dd\ub9ac\uc758\ud559\uc0c1\uc744 \ubc1b\uc558\ub2e4.<\/p>\n<p>\uc2b9\uc778\ub41c \ud56d\uccb4\uce58\ub8cc\uc81c 100\uc885\uc744 \uc9c8\ud658\ubcc4\ub85c \ubcf4\uba74 \uc554\uc774 41\uac1c\ub85c \uac00\uc7a5 \ub9ce\uace0 \uc790\uac00\uba74\uc5ed\uc9c8\ud658\uc778 \ud53c\ubd80\ubcd1\uc774 9\uac1c, \ub958\uba38\ud2f0\uc998\uc774 6\uac1c\ub2e4. \uac10\uc5fc\uc9c8\ud658\ub3c4 7\uac1c\ub85c \uc774 \uac00\uc6b4\ub370 \uc5d0\uc774\uc988\uc640 \uc5d0\ubcfc\ub77c \uce58\ub8cc\uc81c\uac00 \uc788\ub2e4. \ucd5c\uadfc \ucf54\ub85c\ub09819 \uce58\ub8cc\uc81c\ub3c4 \uac1c\ubc1c\ub3fc \uba87 \uac1c\uac00 \uae34\uae09\uc0ac\uc6a9\uc774 \ud5c8\uac00\ub410\uc9c0\ub9cc \uc544\uc9c1 \uc815\uc2dd\uc73c\ub85c \uc2b9\uc778\ub41c \uac74 \uc5c6\ub2e4.<\/p>\n<div>\u25cb \ube44\ub9cc\ub3c4 \ud56d\uccb4 \uce58\ub8cc \uac00\ub2a5\ud560\uae4c<\/div>\n<div><\/div>\n<div class=\"pic_c\">\n<div class=\"nbd_im_w _LAZY_LOADING_WRAP \">\n<div id=\"img_a4\" class=\"nbd_a _LAZY_LOADING_ERROR_HIDE\"><img decoding=\"async\" id=\"img4\" class=\"_LAZY_LOADING\" src=\"https:\/\/imgnews.pstatic.net\/image\/584\/2021\/07\/06\/0000014982_004_20210706173213099.jpg?type=w647\" \/><\/div>\n<\/div>\n<p><span class=\"end_photo_org\"><em class=\"img_desc\">\ubbf8\uad6d \uc6e8\uc77c\ucf54\ub12c\uc758\ub300 \uc5f0\uad6c\uc790\ub4e4\uc740 \uc9c0\ubc29\uc870\uc9c1\uc5d0 \uc788\ub294 \ub300\uc2dd\uc138\ud3ec(<span data-type=\"ore\" data-lang=\"en\">tissue-resident<\/span>\u00a0<span data-type=\"ore\" data-lang=\"en\">macrophage<\/span>)\uac00\u00a0<span data-type=\"ore\" data-lang=\"en\">PDGFcc<\/span>\ub97c \ub0b4\ub193\uc544 \uc8fc\ubcc0 \uc9c0\ubc29\uc138\ud3ec(<span data-type=\"ore\" data-lang=\"en\">adipocyte<\/span>)\uac00 \uc911\uc131\uc9c0\ubc29(<span data-type=\"ore\" data-lang=\"en\">lipid<\/span>)\uc744 \ud761\uc218\ud574 \uc800\uc7a5\ud558\uac8c \ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1c\uacac\ud588\ub2e4.\u00a0<span data-type=\"ore\" data-lang=\"en\">PDGFcc<\/span>\ub97c \ud56d\uc6d0\uc73c\ub85c \ud558\ub294 \ud56d\uccb4\ub97c \ub9cc\ub4e4\uc5b4 \uc0dd\uc950\uc5d0 \ud22c\uc5ec\ud55c \uacb0\uacfc\u00a0<span data-type=\"ore\" data-lang=\"en\">PDGFcc<\/span>\ub97c \uc5c6\uc560 \uc9c0\ubc29 \uc800\uc7a5\uc774 \uc5b5\uc81c\ub418\uace0 \uc9c0\ubc29 \uc5f0\uc18c\uac00 \ucd09\uc9c4\ub3fc \ubab8\ubb34\uac8c\uac00 \uc8fc\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc838 \ube44\ub9cc \uce58\ub8cc\uc81c \uac00\ub2a5\uc131\uc744 \ubcf4\uc5ec\uc92c\ub2e4. \uc0ac\uc774\uc5b8\uc2a4 \uc81c\uacf5<\/em><\/span><\/div>\n<\/div>\n<div><\/div>\n<div><\/div>\n<div class=\"go_trans _article_content\">\ud604\uc7ac \uc9c4\ud589 \uc911\uc778 \ud56d\uccb4\uce58\ub8cc\uc81c \uc784\uc0c1\uc2dc\ud5d8\uc740 860\uc5ec \uac74\uc5d0 \uc774\ub978\ub2e4. \uc774 \uac00\uc6b4\ub370 10%\ub9cc \uc2b9\uc778\uc774 \ub098\ub354\ub77c\ub3c4 2030\ub144 \uc774\ub0b4\uc5d0 200\ubc88\uc9f8 \ud56d\uccb4\uce58\ub8cc\uc81c\uac00 \ub4f1\uc7a5\ud560 \uac83\uc774\ub2e4. \ud56d\uccb4\uce58\ub8cc\uc81c\uc758 \uc801\uc6a9 \ubc94\uc704\ub3c4 \ub113\uc5b4\uc838 \uc2ec\uc9c0\uc5b4 \ube44\ub9cc \uce58\ub8cc\uc81c \ud6c4\ubcf4\ub3c4 \uc788\ub2e4.<\/p>\n<p>\uc9c0\ub09c\ud574 11\uc6d4 \ud559\uc220\uc9c0 \u2018\ubbf8\uad6d\ub9bd\uacfc\ud559\uc6d0\ud68c\ubcf4\u2019\uc5d0\ub294 \ube44\ub9cc \ud56d\uccb4\uce58\ub8cc\uc81c \uc784\uc0c1 1\uc0c1 \uacb0\uacfc\ub97c \ub2f4\uc740 \ub17c\ubb38\uc774 \uc2e4\ub838\ub2e4. \ubbf8\uad6d\uc758 \uc0dd\uba85\uacf5\ud559\ud68c\uc0ac \uc81c\ub128\ud14c\ud06c\uc758 \uc5f0\uad6c\uc790\ub4e4\uc740 \ubab8\uc758 \ub300\uc0ac \ud56d\uc0c1\uc131\uc744 \uc870\uc808\ud558\ub294 \ud638\ub974\ubaac\uc778\u00a0<span data-type=\"ore\" data-lang=\"en\">FGF21<\/span>\uc758 \uae30\ub2a5\uc744 \ubaa8\ubc29\ud558\ub294 \ud56d\uccb4\ub97c \ub9cc\ub4e4\uc5c8\ub2e4.<\/p>\n<p><span data-type=\"ore\" data-lang=\"en\">FGF21<\/span>\uc740 \uc9c0\ubc29\uc138\ud3ec\uc640 \ucdcc\uc7a5\uc138\ud3ec, \uc2e0\uacbd\uc138\ud3ec\uc758 \ud45c\uba74\uc5d0 \uc788\ub294 \uc218\uc6a9\uccb4\uc778\u00a0<span data-type=\"ore\" data-lang=\"en\">FGFR1<\/span>\/<span data-type=\"ore\" data-lang=\"en\">KLB<\/span>\uc5d0 \ub2ec\ub77c\ubd99\uc5b4 \uc5d0\ub108\uc9c0\ub97c \uc18c\ubaa8\ud558\uace0 \uc2dd\uc695\uc744 \ub5a8\uc5b4\ub728\ub9ac\ub294 \uc2e0\ud638\ub97c \ub0b4\ubcf4\ub0b4\uac8c \ud55c\ub2e4. \ub530\ub77c\uc11c \uc678\ubd80\uc5d0\uc11c\u00a0<span data-type=\"ore\" data-lang=\"en\">FGF21<\/span>\uc744 \ud22c\uc5ec\ud574 \ube44\ub9cc\uc744 \uce58\ub8cc\ud558\ub294 \uc2dc\ub3c4\uac00 \uc788\uc5c8\uc9c0\ub9cc \ubab8 \uc548\uc5d0\uc11c \uae08\ubc29 \ud30c\uad34\ub3fc \ubc18\ubcf5\uc801\uc73c\ub85c \ud22c\uc5ec\ud574\uc57c \ud558\ub294 \ubb38\uc81c\uac00 \uc788\ub2e4.<\/div>\n<div class=\"go_trans _article_content\">\n\uc5f0\uad6c\uc790\ub4e4\uc740\u00a0<span data-type=\"ore\" data-lang=\"en\">FGFR1<\/span>\/<span data-type=\"ore\" data-lang=\"en\">KLB<\/span>\uc5d0 \ub2ec\ub77c\ubd99\uc5b4\u00a0<span data-type=\"ore\" data-lang=\"en\">FGF21<\/span>\u00a0\uae30\ub2a5\uc744 \ubaa8\ubc29\ud558\ub294 \ud56d\uccb4\ub97c \uc120\ubcc4\ud574 \ube44\ub9cc\uc778 \uc0ac\ub78c\ub4e4\uc5d0\uac8c 1\ud68c \uc8fc\uc0ac\ud588\ub2e4. \ud56d\uccb4\ub294 \ud55c \ub2ec \ub3d9\uc548 \uccb4\ub0b4\uc5d0 \uba38\ubb34\ub974\uba70 \ud45c\uc801\uc5d0 \uacb0\ud569\ud574 \uc2e0\ud638\ub97c \ubcf4\ub0c8\uace0 \uadf8 \uacb0\uacfc 3\uc8fc \ub4a4 \ubab8\ubb34\uac8c\uac00 2% \uc815\ub3c4 \uc904\uc5c8\ub2e4. \uc124\ubb38 \uc870\uc0ac \uacb0\uacfc \ud56d\uccb4\ub97c \ud22c\uc5ec\ubc1b\uc740 \uc0ac\ub78c\ub4e4\uc740 \uc2dd\uc695\uc774 \ub5a8\uc5b4\uc84c\ub294\ub370 \ud2b9\ud788 \ub2e8\ub9db\uc774 \ub9ce\uc774 \ub098\ub294 \uc218\ud654\ubb3c\uc5d0 \ub300\ud55c \uc120\ud638\ub3c4\uac00 \ub0ae\uc544\uc84c\ub2e4. \ubd80\uc791\uc6a9\uc73c\ub85c\ub294 \uba87\uba87 \uc0ac\ub78c\ub4e4\uc774 \uba54\uc2a4\uaebc\uc6c0\uc744 \ubcf4\uace0\ud588\ub2e4. \uc774 \uacb0\uacfc\ub97c \ubc14\ud0d5\uc73c\ub85c \uc5f0\uad6c\uc790\ub4e4\uc740 \uc784\uc0c1 2\uc0c1\uc744 \uc900\ube44\ud558\uace0 \uc788\ub2e4.<\/p>\n<p>\uad6d\uc81c\ud559\uc220\uc9c0 \u2018\uc0ac\uc774\uc5b8\uc2a4\u2019 7\uc6d4 2\uc77c\uc790\uc5d0\ub294 \uc9c0\ubc29\uc870\uc9c1\uc5d0 \uc0c1\uc8fc\ud558\ub294 \ub300\uc2dd\uc138\ud3ec\uac00 \ubd84\ube44\ud558\ub294 \uc2e0\ud638\ubd84\uc790\uc778\u00a0<span data-type=\"ore\" data-lang=\"en\">PDGFcc<\/span>\ub97c \ud56d\uc6d0\uc73c\ub85c \ud558\ub294 \ud56d\uccb4\uac00 \ube44\ub9cc\uce58\ub8cc\uc81c\uac00 \ub420 \uc218 \uc788\ub2e4\ub294 \ub3d9\ubb3c\uc2e4\ud5d8\uacb0\uacfc\uac00 \uc2e4\ub838\ub2e4. \uc120\ucc9c\uba74\uc5ed\uacc4\uc758 \uad6c\uc131\uc6d0\uc778 \ub300\uc2dd\uc138\ud3ec\ub294 \uba74\uc5ed\ubfd0 \uc544\ub2c8\ub77c \ub2e4\uc591\ud55c \uae30\ub2a5\uc744 \uc218\ud589\ud55c\ub2e4.<\/p>\n<p>\ubbf8\uad6d \uc6e8\uc77c\ucf54\ub12c\uc758\ub300 \uc5f0\uad6c\uc790\ub4e4\uc740 \uc9c0\ubc29\uc870\uc9c1\uc5d0 \uc788\ub294 \ub300\uc2dd\uc138\ud3ec\uac00 \uc9c0\ubc29\uc138\ud3ec\uc758 \uc9c0\ubc29 \uc800\uc7a5 \uacfc\uc815\uc5d0 \uc801\uadf9\uc801\uc73c\ub85c \uad00\uc5ec\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1d\ud600\ub0c8\ub2e4. \uace0\uc9c0\ubc29 \uba39\uc774\ub97c \uba39\uc740 \uc0dd\uc950\uc758 \uc9c0\ubc29\uc870\uc9c1 \ub300\uc2dd\uc138\ud3ec\ub294\u00a0<span data-type=\"ore\" data-lang=\"en\">PDGFcc<\/span>\ub97c \ub0b4\ub193\uace0 \uc774\ub97c \uc778\uc9c0\ud55c \uc8fc\ubcc0 \uc9c0\ubc29\uc138\ud3ec\uac00 \uc911\uc131\uc9c0\ubc29\uc744 \ud761\uc218\ud574 \uc800\uc7a5\ud55c\ub2e4.<\/p>\n<p><span data-type=\"ore\" data-lang=\"en\">PDGFcc<\/span>\ub97c \ud56d\uc6d0\uc73c\ub85c \ud558\ub294 \ud56d\uccb4\ub97c \ub9cc\ub4e4\uc5b4 \ud22c\uc5ec\ud558\uc790 \uc9c0\ubc29 \ucd95\uc801\uc774 \uc904\uc5c8\uace0 \ub300\uc2e0 \uc9c0\ubc29\uc744 \ud0dc\uc6b0\ub294 \uc5f4\uc0dd\uc131\uc774 \ud65c\uc131\ud654\ub410\ub2e4. \ubc18\uba74 \uc2dd\uc695\uc5d0\ub294 \uc601\ud5a5\uc744 \ubbf8\uce58\uc9c0 \uc54a\uc558\ub2e4. \uc5f0\uad6c\uc790\ub4e4\uc740 \uc0ac\ub78c\uc744 \ub300\uc0c1\uc73c\ub85c \uc784\uc0c1\uc2dc\ud5d8\uc744 \uc9c4\ud589\ud560 \uacc4\ud68d\uc774\ub2e4. \uba38\uc9c0\uc54a\uc544 \ud55c \ub2ec\uc5d0 \uc8fc\uc0ac \ud55c \ubc29\uc774\uba74 \uc0b4\uc744 \ube84 \uc218 \uc788\ub294 \ud56d\uccb4 \ub2e4\uc774\uc5b4\ud2b8 \uc2dc\ub300\uac00 \uc5f4\ub9ac\uc9c0 \uc54a\uc744\uae4c.<\/p>\n<p>\uc9c0\ub09c 5\uc6d4 \uc5f4\ub9b0 \uac74\uac15\ubcf4\ud5d8\uc2ec\uc0ac\ud3c9\uac00\uc6d0 \uc0b0\ud558 \uc911\uc99d(\uc554)\uc9c8\ud658\uc2ec\uc758\uc704\uc6d0\ud68c \ud68c\uc758\uc5d0\uc11c 1\ucc28 \uce58\ub8cc\ub85c \ud0a4\ud2b8\ub8e8\ub2e4 \uae09\uc5ec\ub97c \uc778\uc815\ud560\uc9c0 \ub17c\uc758\ud588\uc9c0\ub9cc(2017\ub144 \uc774\ud6c4 \uc5ec\ub35f \ubc88\uc9f8\ub2e4) \uacb0\uacfc\ub294 \ub610 \uc2ec\uc758 \ubcf4\ub958\uc600\ub2e4. \uc81c\uc57d\ud68c\uc0ac\uac00 \uac00\uaca9 \uc870\uc815\uc548\uc744 \uc81c\uc2dc\ud588\uc9c0\ub9cc 1\ucc28 \uce58\ub8cc\ubd80\ud130 \uc801\uc6a9\ud558\uae30\uc5d0\ub294 \uc5ec\uc804\ud788 \uac74\ubcf4 \uc7ac\uc815\uc5d0 \ud070 \ubd80\ub2f4\uc774 \ub410\ub098 \ubcf4\ub2e4. \uc774\ub7ec\ub2e4\uac00 \ud2b9\ud5c8\uac00 \ud480\ub824 \ubcf5\uc81c\uc57d\uc774 \ub098\uc62c \ub54c\uae4c\uc9c0 \uae30\ub2e4\ub824\uc57c \ud560\uc9c0\ub3c4 \ubaa8\ub974\uaca0\ub2e4. \ucc38\uace0\ub85c\u00a0<span data-type=\"ore\" data-lang=\"en\">OECD<\/span>\u00a0\uacbd\uc81c \uaddc\ubaa8 \uc0c1\uc704 10\uac1c\uad6d \uac00\uc6b4\ub370 \uc6b0\ub9ac\ub098\ub77c\ub9cc 1\ucc28 \uce58\ub8cc \uc801\uc6a9\uc774 \uc548 \ub41c\ub2e4. \ud56d\uccb4\uce58\ub8cc\uc81c \uc2dc\ub300\uc758 \ud61c\ud0dd\uc744 \uc880 \ub354 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc774 \ub204\ub838\uc73c\uba74 \ud558\ub294 \ubc14\ub78c\uc774\ub2e4.<\/div>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\uc544\ub798\ub294 2023\ub144 7\uc6d4 16\uc77c \ub274\uc2a4\uc785\ub2c8\ub2e4~<\/p>\n<p>(\uc6d0\ubb38: <a href=\"https:\/\/n.news.naver.com\/mnews\/article\/018\/0005531339\">\uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n<p>&nbsp;<\/p>\n<div class=\"media_end_head go_trans\">\n<div class=\"media_end_head_title\">\n<h2 id=\"title_area\" class=\"media_end_head_headline\">\ud608\uc561\uc554 CAR-T \uc2dc\uc7a5 \ub178\ub9ac\ub294 ADC \u2018\uc9c4\ub860\ud0c0\u2019[\ube14\ub85d\ubc84\uc2a4\ud130 \ud1ba\uc544\ubcf4\uae30]<\/h2>\n<\/div>\n<div class=\"media_end_head_info nv_notrans \">\n<div class=\"media_end_head_info_datestamp\"><\/div>\n<div class=\"media_end_head_info_variety\">\n<div class=\"media_end_head_info_variety_right\">\n<div class=\"media_end_head_print\"><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<div id=\"contents\" class=\"newsct_body\">\n<div id=\"newsct_article\" class=\"newsct_article _article_body\">\n<div id=\"dic_area\" class=\"go_trans _article_content\"><strong class=\"media_end_summary\"><span data-type=\"ore\" data-lang=\"en\">CD19<\/span>\u00a0\ud0c0\uae43 \ud608\uc561\uc554 3\ucc28 \uce58\ub8cc\uc81c \uc2dc\uc7a5 \ub204\ube44\ub294 &#8216;\uc9c4\ub860\ud0c0&#8217;<br \/>\n3\ucc28\u2192 2\ucc28 \uce58\ub8cc\uc81c\ub85c \ud655\ub300\ub41c\u00a0<span data-type=\"ore\" data-lang=\"en\">CAR-T<\/span>\u00a0&#8216;\uc608\uc2a4\uce74\ud0c0&#8217; \ucd94\uaca9<br \/>\n\uc9c4\ub860\ud0c0+\ub9d9\ud14c\ub77c \ud608\uc561\uc554 1\ucc28 \uce58\ub8cc \ubcd1\uc6a9 \uc784\uc0c1 2\uc0c1\ub3c4 \uc9c4\ud589<\/strong><\/div>\n<div><\/div>\n<div class=\"go_trans _article_content\">\n<p><b>2022\ub144 \ud55c \ud574 \ub3d9\uc548 \uc9c4\ud589\ub410\ub358 \u2018\ube14\ub85d\ubc84\uc2a4\ud130 \ud1ba\uc544\ubcf4\uae30 \ud30c\ud2b81\u2019\uc740 3\ub144 \uc804\uc778 2020\ub144 \uc138\uacc4\uc5d0\uc11c \uac00\uc7a5 \ub9ce\uc774 \ud314\ub9b0 \uc758\uc57d\ud488 1~55\uc704\ub97c \ucc28\ub840\ub85c \ub2e4\ub918\ub2e4. \u2018\ube14\ub85d\ubc84\uc2a4\ud130 \ud1ba\uc544\ubcf4\uae30 \ud30c\ud2b82\u2019\ub294 \uc9c0\ub09c\ud574 \uc0c8\ub86d\uac8c 10\uc5b5 \ub2ec\ub7ec \uc774\uc0c1 \ub9e4\ucd9c\uc744 \uc62c\ub838\uac70\ub098 3~4\ub144 \ub0b4\ub85c \uadf8\uc5d0 \uc0c1\uc751\ud558\ub294 \ub9e4\ucd9c\uc744 \uc62c\ub9b4 \uac83\uc73c\ub85c \uc608\uc0c1\ub418\ub294 \uc57d\ubb3c\uc744 \ud558\ub098\uc529 \ubc1c\uad74\ud574 \ub2e4\ub8ec\ub2e4. \uc774\ub978\ubc14 \uc2e0\ud765 \ube14\ub85d\ubc84\uc2a4\ud130\ub85c \ub5a0\uc624\ub978 \uc57d\ubb3c\uc758 \ud0c4\uc0dd\uacfc\uc815\uacfc \ub9e4\ucd9c \uc804\ub9dd \ub4f1\uc744 \ub450\ub8e8 \uc0b4\ud3b4\ubcf8\ub2e4.<\/b><\/p>\n<table class=\"nbd_table\">\n<tbody>\n<tr>\n<td>\n<table class=\"nbd_table\">\n<tbody>\n<tr>\n<td>\n<div class=\"nbd_im_w _LAZY_LOADING_WRAP \">\n<div id=\"img_a1\" class=\"nbd_a _LAZY_LOADING_ERROR_HIDE\"><img decoding=\"async\" id=\"img1\" class=\"_LAZY_LOADING\" src=\"https:\/\/imgnews.pstatic.net\/image\/018\/2023\/07\/16\/0005531339_001_20230716130101029.jpg?type=w647\" \/><\/div>\n<\/div>\n<\/td>\n<\/tr>\n<tr>\n<td>\uc2a4\uc704\uc2a4\u00a0<span data-type=\"ore\" data-lang=\"en\">ADC<\/span>\u00a0\ud14c\ub77c\ud4e8\ud2f1\uc2a4\uac00 \uac1c\ubc1c\ud55c \uc815\ub9e5\uc8fc\uc0ac\ud615 \uac70\ub300 B\uc138\ud3ec \ub9bc\ud504\uc885 \uce58\ub8cc\uc81c \u2018\uc9c4\ub860\ud0c0\u2019(\uc131\ubd84\uba85 \ub860\uce74\uc2a4\ud22d\uc2dc\ub9d9 \ud14c\uc2dc\ub9b0)(\uc81c\uacf5=<span data-type=\"ore\" data-lang=\"en\">ADC<\/span>\u00a0\ud14c\ub77c\ud4e8\ud2f1\uc2a4)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\uc2a4\uc704\uc2a4\u00a0<span data-type=\"ore\" data-lang=\"en\">ADC<\/span>\u00a0\ud14c\ub77c\ud4e8\ud2f1\uc2a4\uac00 \uac1c\ubc1c\ud55c \uc815\ub9e5\uc8fc\uc0ac\ud615 \uac70\ub300 B\uc138\ud3ec \ub9bc\ud504\uc885 \uce58\ub8cc\uc81c \u2018\uc9c4\ub860\ud0c0\u2019(\uc131\ubd84\uba85 \ub860\uce74\uc2a4\ud22d\uc2dc\ub9d9 \ud14c\uc2dc\ub9b0)\uac00 \uc9c0\ub09c\ud574 7490\ub9cc \ub2ec\ub7ec(\ud55c\ud654 \uc57d 953\uc5b5\uc6d0)\uc758 \ub9e4\ucd9c\uc744 \uc62c\ub838\ub2e4. \ud2b9\ud788 4\ubd84\uae30 \ub9e4\ucd9c\uc740 1980\ub9cc \ub2ec\ub7ec\ub85c \uc804\ub144 \ub3d9\uae30 \ub300\ube44 16.5% \uc131\uc7a5\ud588\ub2e4.<\/p>\n<p>\ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(<span data-type=\"ore\" data-lang=\"en\">FDA<\/span>)\uc774 2021\ub144 4\uc6d4 \uac70\ub300 B\uc138\ud3ec \ub9bc\ud504\uc885 \ud658\uc790\uc758 3\ucc28 \uc774\uc0c1 \uce58\ub8cc\uc81c\ub85c \uac00\uc18d\uc2b9\uc778\ud55c \uc9c4\ub860\ud0c0\uc758 \uc131\uc7a5\uc138\ub294 \uc62c\ud574 \uae09\ubb3c\uc0b4\uc744 \ud0c8 \uc218 \uc788\ub2e4\ub294 \uc804\ub9dd\uc774 \ub098\uc654\ub2e4. \uc9c0\ub09c\ud574 12\uc6d4 \uc720\ub7fd\uc758\uc57d\ud488\uccad\ub3c4 \uac19\uc740 \uc801\uc751\uc99d\uc73c\ub85c \uc774\ub97c \uc870\uac74\ubd80 \uc2b9\uc778\ud558\uba74\uc11c\ub2e4.\u00a0<span data-type=\"ore\" data-lang=\"en\">ADC<\/span>\u00a0\ud14c\ub77c\ud4e8\ud2f1\uc2a4 \uce21\uc740 \uc9c0\ub09c 2\ubd84\uae30 \uc720\ub7fd \ud30c\ud2b8\ub108\uc0ac\uc778 \uc18c\ube44\ub97c \ud1b5\ud574 \uc9c4\ub860\ud0c0\ub97c \ucd9c\uc2dc\ud55c \uac83\uc73c\ub85c \uc54c\ub824\uc84c\ub2e4.<\/p>\n<p>\ud56d\uccb4\uc57d\ubb3c\uc811\ud569(<span data-type=\"ore\" data-lang=\"en\">ADC<\/span>) \uae30\uc220\ub85c \ud0c4\uc0dd\ud55c \uc9c4\ub860\ud0c0\ub294 B\uc138\ud3ec \ud45c\uba74\uc5d0 \ub9ce\uc740\u00a0<span data-type=\"ore\" data-lang=\"en\">CD19<\/span>\uc744 \ud0c0\uae43\ud55c\ub2e4. 2017\ub144\ubd80\ud130 \uc8fc\uc694\uad6d\uc5d0\uc11c \uc2b9\uc778\ub418\uae30 \uc2dc\uc791\ud55c \ud0a4\uba54\ub9ad\ud56d\uc6d0\uc218\uc6a9\uccb4(<span data-type=\"ore\" data-lang=\"en\">CAR<\/span>)<span data-type=\"ore\" data-lang=\"en\">-T<\/span>\uce58\ub8cc\uc81c\uc640 \ud45c\uc801\ud558\ub294 \ubd80\uc704\uac00 \uacb9\uce58\ub294 \uac83\uc774\ub2e4. \uc2a4\uc704\uc2a4 \ub178\ubc14\ud2f0\uc2a4\uc758 \u2018\ud0b4\ub9ac\uc544\u2019\uc640 \ubbf8\uad6d \uae38\ub9ac\uc5b4\ub4dc\uc0ac\uc774\uc5b8\uc2a4\uc758 \u2018\uc608\uc2a4\uce74\ud0c0\u2019 \ub4f1\uc744 \ud3ec\ud568\ud55c 4\uc885\uc758\u00a0<span data-type=\"ore\" data-lang=\"en\">CD19<\/span>\u00a0\ud0c0\uae43\u00a0<span data-type=\"ore\" data-lang=\"en\">CAR-T<\/span>\uce58\ub8cc\uc81c\uac00 \ud608\uc561\uc554 \ub300\uc0c1 3\ucc28 \uce58\ub8cc\uc81c\ub85c \ucd08\uae30 \uc801\uc751\uc99d\uc744 \ud68d\ub4dd\ud558\uba70 \ubbf8\uad6d\uc774\ub098 \uc720\ub7fd\uc5f0\ud569(<span data-type=\"ore\" data-lang=\"en\">EU<\/span>) \ub4f1\uc5d0\uc11c \uc2dc\ud310\ub41c \ubc14 \uc788\ub2e4. \ud2b9\ud788 \ucd5c\ucd08\uc758\u00a0<span data-type=\"ore\" data-lang=\"en\">CAR-T<\/span>\u00a0\uce58\ub8cc\uc81c\uc778 \ud0b4\ub9ac\uc544\uc758 \uc7ac\ubc1c\uc131 \ub610\ub294 \ubd88\uc751\uc131 \ubbf8\ub9cc\uc131 \uac70\ub300 B\uc138\ud3ec \ub9bc\ud504\uc885(<span data-type=\"ore\" data-lang=\"en\">DLBCL<\/span>) \uc784\uc0c1\uc5d0\uc11c \ub3c4\ucd9c\ub41c \uc644\uc804\uad00\ud574\uc728(\uc644\uce58\uc728)\uc774 30~40%\uc600\uc9c0\ub9cc, \uc9c4\ub860\ud0c0\uc758 \uc644\uc804\uad00\ud574\uc728\uc740 61%\uc5d0 \ub2ec\ud574 \uc8fc\ubaa9\ubc1b\uc558\ub2e4.<\/p>\n<p>\uc5b4\ubc0b \ub9d0\ub9ac\ud06c\u00a0<span data-type=\"ore\" data-lang=\"en\">ADC<\/span>\ud14c\ub77c\ud4e8\ud2f1\uc2a4\u00a0<span data-type=\"ore\" data-lang=\"en\">CEO<\/span>\ub294 \uc62c\ud574 \ucd08 \u201c\uc9c4\ub860\ud0c0 \uad00\ub828 \ubcd1\uc6a9\uc694\ubc95\uc774\ub098 \uc801\uc751\uc99d \ud655\uc7a5 \uc2dc\ub3c4\uac00 \uc9c4\ud589\ub418\uace0 \uc788\ub2e4\u201d\uba70 \u201c\uc5f0\uac04 \ub9e4\ucd9c \uc7a0\uc7ac\ub825\uc740 5\uc5b5<span data-type=\"ore\" data-lang=\"en\">~10<\/span>\uc5b5 \ub2ec\ub7ec\ubc94\uc704\ub85c \uc99d\uac00\ub420 \uac83\u201d\uc774\ub77c\uace0 \uc804\ub9dd\ud588\ub2e4.<\/p>\n<p>\ud55c\ud3b8 \uacbd\uc7c1 \uc57d\ubb3c\uc778 \uc608\uc2a4\uce74\ud0c0\uc758 \uacbd\uc6b0\u00a0<span data-type=\"ore\" data-lang=\"en\">DLBCL<\/span>\uc774\ub098 B\uc138\ud3ec \uae09\uc131 \ub9bc\ud504\uad6c\uc131 \ubc31\ud608\ubcd1 \ub4f1\uc758 \uc801\uc751\uc99d\uc5d0 \ub300\ud574 3\ucc28 \uce58\ub8cc\uc81c\ub85c \uc2b9\uc778\ub410\uc5c8\ub2e4. \ucd5c\uadfc \ubbf8\uad6d\uacfc \uc720\ub7fd \ub4f1\uc5d0\uc11c \ud574\ub2f9 \uc801\uc751\uc99d\uc758 2\ucc28 \uce58\ub8cc\uc81c\ub85c \uac01\uac01 \uc9c0\ub09c\ud574 5\uc6d4\uacfc 10\uc6d4\uc5d0 \ud655\uc7a5 \uc2b9\uc778\ub410\ub2e4. \uc774\ub97c \ud1b5\ud574 \uc608\uc2a4\uce74\ud0c0\uac00\u00a0<span data-type=\"ore\" data-lang=\"en\">CAR-T<\/span>\u00a0\uc2dc\uc7a5\uc744 \uc120\ub3c4\ud558\uac8c \ub410\ub2e4.<\/p>\n<p><span data-type=\"ore\" data-lang=\"en\">ADC<\/span>\u00a0\ud14c\ub77c\ud4e8\ud2f1\uc2a4 \uc5ed\uc2dc \uc9c4\ub860\ud0c0\uc758 \ub9e4\ucd9c \ud655\ub300\ub97c \uc704\ud574 B\uc138\ud3ec \ub9bc\ud504\uc885 \uad00\ub828 1\ucc28 \uce58\ub8cc \uc801\uc751\uc99d\uc744 \ud68d\ub4dd\ud558\ub824 \uc560\uc4f0\uace0 \uc788\ub2e4. \ud68c\uc0ac\ub294 \uc2a4\uc704\uc2a4 \ub85c\uc288 \uacf5\ub3d9\uc73c\ub85c \uc9c4\ub860\ud0c0\uc640 \u2018\ub9d9\ud14c\ub77c\u2019(\uc131\ubd84\uba85 \ub9ac\ud22d\uc2dc\ub9d9)\uc744 \uc774\uc804\uc5d0 \uce58\ub8cc\ubc1b\uc740 \uc801\uc774 \uc5c6\uace0 \ubab8\uc0c1\ud0dc\uac00 \uc88b\uc9c0 \uc54a\uc740\u00a0<span data-type=\"ore\" data-lang=\"en\">DLBCL<\/span>\u00a0\ud658\uc790 \ub300\uc0c1 1\ucc28 \uce58\ub8cc\uc81c\ub85c \ubcd1\uc6a9\ud22c\uc5ec\ud558\ub294 \uc784\uc0c1 2\uc0c1\uc744 \uc9c4\ud589\ud558\ub294 \uc911\uc774\uc5c8\ub2e4.<\/p>\n<p>\uadf8\ub7f0\ub370 \uc774 \uac19\uc740 \uc9c4\ub860\ud0c0\uc758 \uc8fc\uc694 \uc801\uc751\uc99d \ud655\ub300 \uacc4\ud68d\uc758 \ucc28\uc9c8\uc774 \ube5a\uc5b4\uc9c8 \uc804\ub9dd\uc774\ub2e4. \uc9c0\ub09c 14\uc77c\u00a0<span data-type=\"ore\" data-lang=\"en\">ADC<\/span>\ud14c\ub77c\ud4e8\ud2f1\uc2a4\ub294 \uc9c4\ub860\ud0c0\uc640 \ub9d9\ud14c\ub77c\uc758 \ubcd1\uc6a9 \uc784\uc0c1 2\uc0c1\uc744 \uc790\ubc1c\uc801\uc73c\ub85c \uc77c\uc2dc \uc911\ub2e8\ud55c\ub2e4\uace0 \ubc1d\ud614\ub2e4. \ud574\ub2f9 \uc784\uc0c1 \uacfc\uc815\uc5d0\uc11c 3~5\uae09\uc758 \ubd80\uc791\uc6a9\uc774 \ubc1c\uc0dd\ud558\uba74\uc11c\ub2e4. 5\uae09 \ubd80\uc791\uc6a9\uc73c\ub85c \ubd84\ub958\ub418\ub294 \ud638\ud761\uae30 \uad00\ub828 \ud658\uc790 \uc0ac\ub9dd 7\uac74\uacfc 3~4\uae09 \uc218\uc900\uc758 \ud638\ud761\uae30 \uad00\ub828 \uc774\uc0c1 \uc0ac\ub840 5\uac74\uc774 \ub098\uc628 \uac83\uc774\ub2e4. \ud56d\uc554\uc81c \uc784\uc0c1\uc5d0\uc11c \ubd80\uc791\uc6a9\uc740 1~2\uae09\uc740 \ube44\uad50\uc801 \uacbd\ubbf8\ud55c \uc0c1\ud0dc\ub97c, \uadf8 \uc774\uc0c1\uc740 \uc2ec\uac01\ud55c \ubd80\uc791\uc6a9\uc73c\ub85c \ubd84\ub958\ud558\uace0 \uc788\ub2e4.<\/p>\n<p>\ud68c\uc0ac \uce21\uc740 12\uac74\uc758 \uc774\uc0c1 \uc0ac\ub840 \uc911 11\uac74\uc774 \uc784\uc0c1 \uc57d\ubb3c\uacfc \uad00\ub828\uc774 \uc5c6\uac70\ub098 \uac00\ub2a5\uc131\uc774 \ub0ae\uc740 \uac83\uc73c\ub85c \ud3c9\uac00\ud558\uace0 \uc788\ub2e4. \ub610 3~5\uae09\uc758 \uc0ac\ub840 5\uac74\uc911 4\uac74\uc774 \ud574\uacb0\ub410\uc73c\uba70, \uc784\uc0c1 \uacc4\ud68d\uc5d0 \ub530\ub77c \ud22c\uc5ec\ub97c \uc644\ub8cc\ud588\ub2e4\uace0 \ubc1d\ud614\ub2e4.<\/p>\n<p>\ub9d0\ub9ad\u00a0<span data-type=\"ore\" data-lang=\"en\">CEO<\/span>\ub294 \u201c\uc0c1\ud0dc \uba74\uc5d0\uc11c \ub9e4\uc6b0 \uce58\ub8cc\ud558\uae30 \uae4c\ub2e4\ub85c\uc6b4 \ud658\uc790\ub4e4\uc5d0\uac8c \uc9c4\ub860\ud0c0\uc640 \ub9d9\ud14c\ub77c\uc758 \ubcd1\uc6a9\uc784\uc0c1\uc774 \uc2dc\ub3c4\ub418\uace0 \uc788\ub2e4\u201d\uba70 \u201c\uc548\uc804\uc744 \ucd5c\uc6b0\uc120\ud558\uba70 \ub2e8\uacc4\ubcc4\ub85c \ucda9\uc2e4\ud788 \ub2f9\uad6d\uc5d0 \ubcf4\uace0\ud558\uba74\uc11c \uc784\uc0c1\uc744 \uc9c4\ud589\ud560 \uacc4\ud68d\u201d\uc774\ub77c\uace0 \ub9d0\ud588\ub2e4.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; \uaca8\uc6b8\uc774 \uc9c0\ub098\uba74\uc11c \ub0ae\uc774 \uae38\uc5b4\uc9c0\uba74 \ub354 \uc774\uc0c1 \ucc2c\ubc14\ub78c\uc5d0 \ucf54\uac00 \uc2dc\ub9ac\uc9c0 \uc54a\uc8e0. \ud558\uc9c0\ub9cc \ub0a0\uc528\uac00 \ub530\ub73b\ud574\uc9c0\ub294 \uc2dc\uae30\uc5d0 \uace4\uacbd\uc5d0 \ucc98\ud558\ub294 \uc0ac\ub78c\ub4e4\uc774 \uc788\uc5b4\uc694. \uadf8\ub798\uc11c \ub9e4\ub144 \ubd04\ub9cc \ub418\uba74 \uc804\uc7c1\uc744<a href=\"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4701\" class=\"more-link\">(more&#8230;)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[41,44,38,32,33,34,29],"tags":[],"class_list":["post-4701","post","type-post","status-publish","format-standard","hentry","category-05---","category-10------11--","category-38","category-essays-on-science","category-do-biology","category-lets-do-chemistry","category-lets-do-science"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":3308,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3308","url_meta":{"origin":4701,"position":0},"title":"\uc54c\ub808\ub974\uae30\uc758 \uc2b5\uaca9 &#8211;  \ud56d\uc6d0\uacfc \uba74\uc5ed\uccb4\uacc4\uc758 &#8216;\uc798\ubabb\ub41c \ub9cc\ub0a8&#8217;","author":"biochemistry","date":"April 17, 2019","format":false,"excerpt":"\u00a0 \u00a0 \uc6b0\ub9ac\ub294 \ubd04\uc758 \uae30\uc6b4\uc744 \ubab8\uc73c\ub85c \ub290\ub084 \uc218 \uc788\uc5b4\uc694! \uaca8\uc6b8\uc774 \uc9c0\ub098\uba74 \ub0ae\uc774 \uae38\uc5b4\uc9c0\uace0 \ub354 \uc774\uc0c1 \ucc2c\ubc14\ub78c\uc5d0 \ucf54\uac00 \uc2dc\ub9ac\uc9c0 \uc54a\uc8e0. \uc5bc\ub9c8 \uc804\uae4c\uc9c0\ub9cc \ud574\ub3c4 \uaf41\uaf41 \uc5bc\uc5b4\ubd99\uc5c8\ub358 \ub3c4\uc2dc\uc758 \uc544\uc2a4\ud314\ud2b8\uc5d0\ub294 \ub208\uc774 \ub179\uc544 \ud758\ub7ec\uc694. \ud558\uc9c0\ub9cc \ub0a0\uc528\uac00 \ub530\ub73b\ud574\uc9c8 \ub54c\ub9c8\ub2e4 \uace4\uacbd\uc5d0 \ucc98\ud558\ub294 \uc0ac\ub78c\ub4e4\uc774 \uc788\uc5b4\uc694. \uadf8\ub798\uc11c \ub9e4\ub144 \ubd04\ub9cc \ub418\uba74 \uc804\uc7c1\uc744 \uc900\ube44\ud558\ub4ef\uc774 \uc758\ub8cc\uc6a9 \ub9c8\uc2a4\ud06c\ub97c \uad6c\uc785\ud558\uace0 \uc57d\uc744 \uc313\uc544\ub193\uc9c0\uc694. \ubc14\ub85c \uc2ec\ud55c\u2026","rel":"","context":"In &quot;'10. \uac1c\uccb4\uc758 \uc815\uccb4\uc131\uacfc \uac1c\uccb4 \uac04 \uc0c1\ud638\uc791\uc6a9'\uacfc '11. \uc9c4\ud654\uc758 \uba54\ucee4\ub2c8\uc998' \uad00\ub828&quot;","block_context":{"text":"'10. \uac1c\uccb4\uc758 \uc815\uccb4\uc131\uacfc \uac1c\uccb4 \uac04 \uc0c1\ud638\uc791\uc6a9'\uacfc '11. \uc9c4\ud654\uc758 \uba54\ucee4\ub2c8\uc998' \uad00\ub828","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=44"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxOTA0MDVfNTEg\/MDAxNTU0NDUwNjQ0MzUy.A374fTj0InA64QSLAjMM4lUrKss1tx2YYepjqSpJRckg.klIx5oZkDaJiQqwWuzpgOPAbYHTdl5bi6Bag4eYdJqEg.JPEG\/shutterstock_1056603149.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxOTA0MDVfNTEg\/MDAxNTU0NDUwNjQ0MzUy.A374fTj0InA64QSLAjMM4lUrKss1tx2YYepjqSpJRckg.klIx5oZkDaJiQqwWuzpgOPAbYHTdl5bi6Bag4eYdJqEg.JPEG\/shutterstock_1056603149.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxOTA0MDVfNTEg\/MDAxNTU0NDUwNjQ0MzUy.A374fTj0InA64QSLAjMM4lUrKss1tx2YYepjqSpJRckg.klIx5oZkDaJiQqwWuzpgOPAbYHTdl5bi6Bag4eYdJqEg.JPEG\/shutterstock_1056603149.jpg?resize=525%2C300&ssl=1 1.5x, 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\uce58\uc720\ub825\uc744 \uc598\uae30\ud558\ub294 \ub9d0\uc774\ub2e4. \uc6b0\ub9ac\u2026","rel":"","context":"In &quot;'10. \uac1c\uccb4\uc758 \uc815\uccb4\uc131\uacfc \uac1c\uccb4 \uac04 \uc0c1\ud638\uc791\uc6a9'\uacfc '11. \uc9c4\ud654\uc758 \uba54\ucee4\ub2c8\uc998' \uad00\ub828&quot;","block_context":{"text":"'10. \uac1c\uccb4\uc758 \uc815\uccb4\uc131\uacfc \uac1c\uccb4 \uac04 \uc0c1\ud638\uc791\uc6a9'\uacfc '11. \uc9c4\ud654\uc758 \uba54\ucee4\ub2c8\uc998' \uad00\ub828","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=44"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3700,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3700","url_meta":{"origin":4701,"position":2},"title":"\ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud56d\ud558\ub294 1\ucc28 \ubc29\uc5b4\ub9c9  \ubab8\uc18d \uacbd\ucc30 \ud2b9\uacf5\ub300","author":"biochemistry","date":"June 7, 2019","format":false,"excerpt":"\u00a0 \u00a0 2015\ub144 \uc6b0\ub9ac\ub098\ub77c\ub97c \uacf5\ud3ec\uc5d0 \ubab0\uc544\ub123\uc5c8\ub358 '\uc911\ub3d9\ud638\ud761\uae30 \uc99d\ud6c4\uad70', \uc989 '\uba54\ub974\uc2a4'\uac00 \ub610 \ud55c\ubc88 '\ud56b\uc774\uc288'\uac00 \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc911\ub3d9 \uad6d\uac00\uc5d0 \ub2e4\ub140\uc628 \ub4a4 \uba54\ub974\uc2a4 \ud655\uc9c4 \ud310\uc815\uc744 \ubc1b\uc740 \ud658\uc790\uc758 \uc6a9\ud0dc\uc640 \uadf8\uac00 \uc811\ucd09\ud55c \uc774\ub4e4\uc758 \uba54\ub974\uc2a4 \ud310\uc815 \uc5ec\ubd80\uc5d0 \uc628 \ub098\ub77c\uac00 \ucd09\uac01\uc744 \uace4\ub450\uc138\uc6b0\uace0 \uc788\uc9c0\uc694. \uba54\ub974\uc2a4\ucc98\ub7fc \ubc14\uc774\ub7ec\uc2a4\uac00 \uc77c\uc73c\ud0a4\ub294 \uc9c8\ubcd1\uc758 \uacbd\uc6b0, \ub300\uaddc\ubaa8 \uc720\ud589\uc73c\ub85c \ubc88\uc9c8 \uac00\ub2a5\uc131\uc774 \ud07d\ub2c8\ub2e4. \ub2e4\ud589\ud788 \uc6b0\ub9ac \ubab8\uc18d\uc5d0\ub294 \uc774\ub7f0 \ubc14\uc774\ub7ec\uc2a4\uc5d0\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do 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\uac1c\ubc1c\ud588\ub2e4.(2018. 2) \u00a0 \u00a0 \ucd9c\ucc98 : pixabay \u00a0 \u00a0 \uc7a5\uae30\uc774\uc2dd\uc758 \ub09c\uc81c\ub85c \uaf3d\ud788\ub358 \uac70\ubd80\ubc18\uc751\uc758 \uc704\ud5d8\uc131\uc744 \uc0ac\uc804\uc5d0 \uc5c6\uc568 \uc218 \uc788\ub294 \uac00\ub2a5\uc131\uc774 \uc5f4\ub838\ub2e4.\u00a0\uadf8\ub3d9\uc548 \uc7a5\uae30\uc774\uc2dd\uc744 \uae30\ub2e4\ub9ac\ub358 \ud658\uc790\ub4e4\uc740 \uc774\uc2dd \ubc1b\uc744\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do 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