{"id":4673,"date":"2019-10-29T20:12:00","date_gmt":"2019-10-29T11:12:00","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=4673"},"modified":"2019-10-29T20:12:00","modified_gmt":"2019-10-29T11:12:00","slug":"%ec%a3%bd%ec%9d%80-%ec%95%bd%ed%98%bc%ec%9e%90%eb%a5%bc-%ec%9c%84%ed%95%b4-%ec%8b%a0%ec%95%bd%ec%9d%84-%ea%b0%9c%eb%b0%9c%ed%95%9c-%ed%99%94%ed%95%99%ec%9e%90-%eb%85%b8%eb%b2%a8%ec%83%9d%eb%a6%ac","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4673","title":{"rendered":"\uc8fd\uc740 \uc57d\ud63c\uc790\ub97c \uc704\ud574 \uc2e0\uc57d\uc744 \uac1c\ubc1c\ud55c \ud654\ud559\uc790, \ub178\ubca8\uc0dd\ub9ac\uc758\ud559\uc0c1\uc744 \ubc1b\ub2e4"},"content":{"rendered":"

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\uac70\ud2b8\ub8e8\ub4dc B. \uc5d8\ub9ac\uc5b8
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1996\ub144, \ub178\uc2a4\uce90\ub864\ub77c\uc774\ub098 \ub9ac\uc11c\uce58 \ud2b8\ub77c\uc774\uc575\uae00 \ud30c\ud06c\uc5d0\uc11c \uac70\ud2b8\ub8e8\ub4dc \uc5d8\ub9ac\uc5b8\uacfc \ub9c9\ub2ec\ub808\ub098 \ud5c8\uae30\ud0c0\uc774 (\uc0ac\uc9c4: \uc774\uc2a4\ud2b8\ubc18 \ud5c8\uae30\ud0c0\uc774)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\uac70\ud2b8\ub8e8\ub4dc \uc5d8\ub9ac\uc5b8\uc758 \uc5b4\ub290 \ud32c \ub808\ud130:<\/b><\/p>\n

“1984\ub144, \ub2e4\uc12f \uc0b4\uc9dc\ub9ac \uc6b0\ub9ac \ub538\uc740 \uae09\uc131 \ub9bc\ud504\uc131 \ubc31\ud608\ubcd1 \uc9c4\ub2e8\uc744 \ubc1b\uace0 \uc5ec\ub7ec \uc57d\ubb3c \uc911\uc5d0\uc11c 6-\uba54\ub974\uce85\ud1a0\ud478\ub9b06-mercaptopurine<\/sub>\uc774 \ud3ec\ud568\ub41c \ud654\ud559\uc694\ubc95 \uce58\ub8cc\ub97c \ubc1b\uc740 \ubc14 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub54c \uc6b0\ub9ac \uac00\uc871\uc740 \uc721\uccb4\uc801\uc73c\ub85c\ub098 \uc815\uc2e0\uc801\uc73c\ub85c \uc815\ub9d0 \uc5b4\ub824\uc6c0\uc744 \ub9ce\uc774 \uacaa\uc5c8\uc2b5\ub2c8\ub2e4. \ud558\uc9c0\ub9cc \uc544\uc774\uc758 \ubcd1\uc5d0 \ucc28\ub3c4\uac00 \uc0dd\uaca8 5\ub144 \ub3d9\uc548 \uc7ac\ubc1c\uc774 \uc5c6\uc5c8\uc73c\uba70, \uc9c0\ub09c 2\ub144 3\uac1c\uc6d4 24\uc77c \ub3d9\uc548 \uc57d\ubb3c\uce58\ub8cc\ub97c \uc804\ud600 \ubc1b\uc9c0 \uc54a\uc558\ub2e4\ub294 \uc810\uc744 \ub9d0\uc500\ub4dc\ub9b4 \uc218 \uc788\uac8c \ub418\uc5b4 \ubb34\ucc99\uc774\ub098 \uae30\uc069\ub2c8\ub2e4! \uc544\uc774\ub294 5\uc6d4\uc5d0 \uc5f4\ud55c \ubc88\uc9f8 \uc0dd\uc77c\uc744 \ub9de\uc774\ud574 \ubd80\ubaa8\uc5d0\uac8c \ud06c\ub098\ud070 \uae30\uc068\uc744 \uc548\uaca8\uc904 \uac83\uc785\ub2c8\ub2e4. \uc2a4\ud3ec\uce20\uacc4 \uac70\ubb3c\uacfc \uc5f0\uc608\uacc4 \uc778\uc0ac\ub4e4\uc5d0 \ub300\ud55c \uacfc\uc7a5\ub41c \ucc2c\uc0ac\ub85c \uac00\ub4dd \ucc2c \uc5b8\ub860 \ub9e4\uccb4\ub97c \uc811\ud558\ub2c8, \ub2f9\uc2e0\uacfc \ub2f9\uc2e0\uc758 \ub3d9\ub8cc\ub4e4\uc774 \uc774 \uc0ac\ud68c\uc5d0 \uadf8\ub807\uac8c \ub9ce\uc774 \uae30\uc5ec\ud588\ub294\ub370 \uc81c\ub300\ub85c \uc778\uc815\ub3c4 \ubabb \ubc1b\uace0 \uc788\ub2e4\ub294 \uc0dd\uac01\uc774 \ub4e4\uc5c8\uc2b5\ub2c8\ub2e4. \ub2f9\uc2e0\uc740 \uc815\ub9d0 \uc9c4\uc815\ud55c \uc601\uc6c5\uc785\ub2c8\ub2e4!”<\/p>\n

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\uc774 \ud3b8\uc9c0\ub294 \uc6b0\ub9ac\uac00 1986\ub144 \ub178\uc2a4\uce90\ub864\ub77c\uc774\ub098 \ub9ac\uc11c\uce58 \ud2b8\ub77c\uc774\uc575\uae00 \ud30c\ud06c\uc758 \uae00\ub77d\uc18c\uc6f0\ucef4\uc5d0 \uc788\ub294 \uac70\ud2b8\ub8e8\ub4dc \uc5d8\ub9ac\uc5b8\uc758 \uc0ac\ubb34\uc2e4\uc744 \ubc29\ubb38\ud588\uc744 \ub54c \uc0ac\ubb34\uc2e4 \ubcbd\uc5d0 \ubd99\uc5b4 \uc788\ub294 \uc218\ub9ce\uc740 \uae00 \uc911 \ud558\ub098\uc600\ub2e4.<\/p>\n

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\uc57d\ud63c\uc790\uc758 \uc8fd\uc74c\uc744 \uc9c0\ucf1c\ubcf8 \uc5d8\ub9ac\uc5b8\uc740 \uce58\ub8cc\ubc95\uc744 \ucc3e\uc544\uc57c\uaca0\ub2e4\uace0 \uacb0\uc2ec\ud588\ub2e4.<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uadf8\ub140\ub294 \uc5b4\ub9b0 \ud559\uc0dd\uc77c \ub54c \uc774\ubbf8 \uc554 \uce58\ub8cc\ubc95\uc744 \ucc3e\uc544\ub0b4\ub294 \ud654\ud559\uc790\uac00 \ub418\uace0 \uc2f6\uc5b4 \ud588\uc5c8\ub2e4. \uadf8\ub7f0 \ud3ec\ubd80\ub97c \uac16\uac8c \ub41c \ub370\uc5d0\ub294 \ub9c8\uc74c \uc544\ud508 \uacc4\uae30\uac00 \uc788\uc5c8\ub2e4. \uadf8\ub140\uac00 \ub300\ud559\uc5d0 \ub4e4\uc5b4\uac00\uae30 \uc804\uc5d0 \ud560\uc544\ubc84\uc9c0\uac00 \uc554\uc73c\ub85c \ub3cc\uc544\uac00\uc2e0 \uac83\uc774\ub2e4. \uadf8 \uc774\ud6c4, \uc544\ud508 \uc0ac\ub78c\ub4e4\uc744 \uc704\ud55c \uce58\ub8cc\ubc95\uc744 \ucc3e\uc544\uc57c\uaca0\ub2e4\ub294 \uacb0\uc2ec\uc740 \uadf8\ub140\uc758 \uc57d\ud63c\uc790\uac00 \uc8fd\uc5c8\uc744 \ub54c \ub354\uc6b1 \uac15\ub82c\ud574\uc84c\ub2e4. \uc57d\ud63c\uc790\ub294 \ud398\ub2c8\uc2e4\ub9b0\uc73c\ub85c \uce58\ub8cc\ub420 \uc218 \uc788\ub294 \ubcd1\uc5d0 \uac78\ub838\uc73c\ub098 \uadf8\ub54c\ub9cc \ud574\ub3c4 \uce58\ub8cc\uac00 \ubd88\uac00\ub2a5\ud588\ub2e4. \uc5bc\ub9c8 \uc9c0\ub098\uc9c0 \uc54a\uc544 \uac00\ub2a5\ud574\uc9c0\uae30\ub294 \ud588\ub2e4. \uc5d8\ub9ac\uc5b8\uc740 \uc0c1\uc0c1\ud560 \uc218 \uc788\ub294 \uac83 \uc774\uc0c1\uc73c\ub85c \uc790\uae30 \ubaa9\ud45c\ub97c \ub208\ubd80\uc2dc\uac8c \uc774\ub8e9\ud574\ub0c8\ub2e4. \uadf8\uac83\uc740 \uadf8\ub140\uac00 1988\ub144 \uc0dd\ub9ac\uc758\ud559\uc0c1 \ubd84\uc57c\uc5d0\uc11c \ub178\ubca8\uc0c1\uc744 \ubc1b\uc73c\uba70 \uc99d\uba85\ub418\uc5c8\ub2e4. \uadf8\ub140\ub294 \uc57d\ubb3c \uce58\ub8cc\uc5d0 \uc0c8\ub85c\uc6b4 \uc6d0\ub9ac\ub97c \uc218\ub9bd\ud55c \uc81c\uc784\uc2a4 \ube14\ub799James W. Black<\/sub>\uacfc \uc870\uc9c0 \ud788\uce6d\uc2a4George H. Hitchings<\/sub>\uc640 \ud568\uaed8 \ub178\ubca8\uc0c1\uc744 \uacf5\ub3d9\uc73c\ub85c \uc218\uc0c1\ud588\ub2e4.<\/p>\n

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\uadf8\ub140\uc758 \uc131\uacf5 \uac00\ub3c4\ub294 \uc218\uc6d4\ud558\uc9c0 \uc54a\uc558\ub2e4. \uc5d8\ub9ac\uc5b8\uc740 \ub274\uc695\uc2dc \uc18c\uc7ac \uc5ec\uc790\ub300\ud559\uc778 \ud5cc\ud130 \ub300\ud559\uad50\ub97c \ub2e4\ub154\ub2e4. \uadf8\uacf3\uc740 \uacbd\uc81c \uc5ec\uac74\uacfc\ub294 \uc0c1\uad00\uc5c6\uc774 \uc131\uc801\uc774 \uc6b0\uc218\ud55c \uc80a\uc740 \uc5ec\uc131\ub4e4\uc758 \uc785\ud559\uc744 \ud5c8\uac00\ud588\ub2e4. \uadf8\ub140\ub294 \uc218\uc11d\uc73c\ub85c \ucd5c\uace0\uc758 \uc601\uc608\ub97c \ub204\ub9ac\uba70 \uc878\uc5c5\ud588\ub2e4. \ub300\ud559 \uc878\uc5c5 \ud6c4, 15\uac1c\uc758 \ub300\ud559\uc6d0\uc5d0 \uc9c0\uc6d0\ud588\uc9c0\ub9cc \uc5b4\ub290 \uacf3\ub3c4 \uadf8\ub140\uc5d0\uac8c \uc7a5\ud559\uae08\uc744 \uc8fc\ub824 \ud558\uc9c0 \uc54a\uc558\ub2e4. \uc720\ub300\uc778\uc774\uba70 \uc5ec\uc790\ub77c\uc11c \ud0d0\ud0c1\uc796\uac8c \uc5ec\uacbc\ub358 \uac83\uc774\ub2e4. \uadf8\ub140\ub294 \ud559\uc0dd\ub4e4\uc744 \uac00\ub974\uce58\uba74\uc11c \ud559\ube44\ub97c \ub9c8\ub828\ud588\ub2e4. \uadf8\ub140\ub294 \ub274\uc695 \ub300\ud559\uad50\uc5d0 \ub4f1\ub85d\ud588\uace0, \uc5f0\uad6c\ub294 \ubc24\uacfc \uc8fc\ub9d0\uc5d0 \ud588\ub2e4. 1941\ub144\uc5d0 \uc11d\uc0ac\ud559\uc704\ub97c \ubc1b\uc558\uace0, \uc77c\uc790\ub9ac\ub97c \uad6c\ud558\ub824 \ud588\uc9c0\ub9cc \uadf8\ub140\uc758 \uacbd\ub825\uc740 \uadf8\ub2e4\uc9c0 \ubc1d\uc544 \ubcf4\uc774\uc9c0 \uc54a\uc558\ub2e4.<\/p>\n

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\u201c\uba74\uc811 \ubcfc \ub54c, \uc2ec\uc0ac\uc704\uc6d0\ub4e4\uc774 \uc774\ub807\uac8c \ub9d0\ud588\uc5b4\uc694. \u2018\uc74c, \ub2f9\uc2e0\uc740 \uc11d\uc0ac\ud559\uc704\ub9cc \uc788\uae30 \ub54c\ubb38\uc5d0 \uc5ec\uae30\uae4c\uc9c0\uac00 \ub2f9\uc2e0\uc774 \uc624\ub97c \uc218 \uc788\ub294 \uac00\uc7a5 \ub192\uc740 \uc790\ub9ac\ub77c\uace0 \ub9d0\ud560 \uc218\ubc16\uc5d0 \uc5c6\ub124\uc694\u2019\ub77c\uace0\u2026. \ub098\ub294 \uadf8\ub7f0 \ub9d0\uc744 \uc65c \ub4e4\uc5b4\uc57c \ud558\ub294\uc9c0 \uc544\uc8fc \uc758\uc544\ud588\uc5b4\uc694. \uadf8\ub4e4\uc740 \ub0b4\uac00 \uc5bc\ub9c8\ub098 \ub2a5\ub825\uc774 \uc788\ub294\uc9c0, \ud639\uc740 \ub0b4\uac00 \uadf8 \uc77c\uc5d0 \uc801\ud569\ud55c\uc9c0 \uadf8\ub7f0 \uac83\ub3c4 \ubab0\ub790\uc2b5\ub2c8\ub2e4. \ub0b4\uac00 \uc5bc\ub9c8\ub098 \ub192\uc740 \uc790\ub9ac\uc5d0 \uc624\ub97c \uc218 \uc788\ub294\uc9c0 \uadf8\ub4e4\uc5d0\uac8c \ubb3b\uc9c0\ub3c4 \uc54a\uc558\uace0\uc694. \ub098\ub294 \uadf8\ub7f0 \uc9c8\ubb38\uc744 \ud558\ub824\ub294 \uc0dd\uac01\uc870\ucc28 \uc5c6\uc5c8\ub2e4\ub2c8\uae4c\uc694. \uc2b9\uc9c4, \uadf8\ub7f0 \uac74 \ubc14\ub77c\uc9c0\ub3c4 \uc54a\uc558\uc5b4\uc694. \ub098\ub294 \uc911\uc694\ud55c \uac83\uc744 \ud558\ub824\uace0 \ud588\uc8e0. \uc815\ub9d0\ub85c \uc554\uc744 \uce58\ub8cc\ud558\uace0 \uc2f6\uc5c8\uc2b5\ub2c8\ub2e4.”<\/b><\/p>\n

“1944\ub144, \uccab \uc778\ud130\ubdf0 \ub54c \ud788\uce6d\uc2a4\uac00 \ud575\uc0b0 \uc720\ub3c4\uccb4\ub4e4\uc744 \uc5f0\uad6c \uc911\uc774\ub77c\uace0 \ub9d0\ud588\ub294\ub370, \ub098\ub294 \ud478\ub9b0<\/b>purine<\/b><\/sub>\uc774\ub098 \ud53c\ub9ac\ubbf8\ub518<\/b>pyrimidine<\/b><\/sub>\uc774 \ubb54\uc9c0 \uc815\ub9d0 \ubab0\ub790\uc5b4\uc694. \ud558\uc9c0\ub9cc \uadf8\uac00 \ub9d0\ud558\ub294 \uac83\uc5d0 \ub9e4\uc6b0 \ud765\ubbf8\uac00 \ub2f9\uae30\ub354\ub77c\uace0\uc694. \uadf8\ub294 \ud575\uc0b0\uc758 \uc0dd\ud654\ud559\uc5d0 \uad00\uc2ec\uc774 \uc788\uc5c8\uc8e0. \u2026 \ud788\uce6d\uc2a4\ub294 \ud2b9\uc815 \ud654\ud569\ubb3c\uc744 \ub9cc\ub4e4\uace0 \uc2f6\uc5b4 \ud588\uc2b5\ub2c8\ub2e4. \ub098\ub294 \ud654\ud559 \uc11d\uc0ac\ud559\uc704\uac00 \uc788\uc5c8\uace0, \uc88b\uc740 \uc131\uc801\uc744 \ubc1b\uc558\uae30 \ub54c\ubb38\uc5d0 \uadf8 \uc77c\uc744 \ud560 \uc218 \uc788\uc744 \uac70\ub77c\uace0 \uc0dd\uac01\ud588\uc5b4\uc694. \ub098\ub294 \ub3c5\uc77c\uc5b4\ub97c \uc77d\uc744 \uc218 \uc788\uc5c8\uae30 \uc5d0 \ub3c5\uc77c\uc5b4\ub85c \ub41c \ubb38\ud5cc\ub4e4\uc744 \uc8fd \ud6d1\uc5b4\ubcf4\uc558\uc8e0. \uc0c1\ub2f9\uc218\uc758 \ucc45\uc774 \uc5d0\ubc00 \ud53c\uc154<\/b>Emil Fischer<\/b><\/sub>\uc758 \uc5f0\uad6c\ub4e4\uc774\ub354\uad70\uc694. \uc9d1\uc5d0\uc11c \uc774\ub514\uc2dc\uc5b4<\/b>Yiddish<\/b><\/sub>(\ub3c5\uc77c\uc5b4 \ud788\ube0c\ub9ac\uc5b4 \ub4f1\uc758 \ud63c\uc131 \uc5b8\uc5b4\u00a0– \uc62e\uae34\uc774)\ub97c \ubc30\uc6e0\uace0, \ub300\ud559 \uc2dc\uc808 \ub3c5\uc77c\uc5b4 \uc218\uc5c5\uc744 \ub4e4\uc5c8\uc2b5\ub2c8\ub2e4. \ud654\ud559\uc790\ub4e4\uc740 \ub3c5\uc77c\uc5b4\ub97c \uc54c\uc544\uc57c \ud588\uc5b4\uc694. \uc804\uc5d0\ub294 \ud560 \uc218 \uc5c6\uc5c8\ub358 \uc77c\uc774\uc9c0\ub9cc \uc804\uc7c1 \uc911\uc774\ub77c \uac11\uc790\uae30 \uc5ec\uc790\ub4e4\uc774 \ud654\ud559 \ubd84\uc57c\uc758 \uc77c\uc790\ub9ac\ub97c \uad6c\ud560 \uc218 \uc788\uc5c8\uc8e0. \ub098\ub294 \ud788\uce6d\uc2a4\uc758 \uc870\uc218\ub85c \uc77c\uc744 \uc2dc\uc791\ud588\uc2b5\ub2c8\ub2e4.”<\/b><\/p>\n

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\ud788\uce6d\uc2a4\uc758 \uc544\uc774\ub514\uc5b4\ub294 \ubc15\ud14c\ub9ac\uc544, \uae30\uc0dd\ucda9 \ubc0f \uc885\uc591\uc138\ud3ec DNA\uc758 \ud2b9\uc815 \uae30\ubcf8 \uc694\uc18c\ub4e4\uc744 \ub300\uccb4\ud558\uc5ec \uc774\uac83\ub4e4\uc758 \uc0dd\uc874\uc744 \ub9c9\ub294 \uac83\uc774\uc5c8\ub2e4. \uadf8\ub294 \uc774 \uae30\ubcf8 \uc694\uc18c\ub4e4\uacfc \ube44\uc2b7\ud55c \ubd84\uc790\ub97c \ucc3e\uace0 \uc788\uc5c8\ub2e4. \uc774\uac83\uc740 \uc57d\ubb3c \uc5f0\uad6c\uc5d0\uc11c \uc77c\ubc18\uc801\uc73c\ub85c \uc2dc\ud589\ud558\ub294 \uc811\uadfc\ubc95\uacfc \ub2e4\ub97c \ubfd0\ub9cc \uc544\ub2c8\ub77c, \uc5f0\uad6c\uc790\ub4e4\uc774 \uadf8 \ub2f9\uc2dc\uc5d0\ub294 \uad00\uc2ec\uc744 \uae30\uc6b8\uc774\uc9c0\ub3c4 \uc54a\ub358 DNA\uc5d0 \ucd08\uc810\uc744 \ub450\uc5c8\uae30 \ub54c\ubb38\uc5d0 \ud601\uc2e0\uc801\uc778 \uc811\uadfc\ubc95\uc774\uc5c8\ub2e4. \uadf8\ub294 \uc5ec\ub7ec \uac00\uc9c0 \ub2e4\ub978 \ud478\ub9b0 \uc720\ub3c4\uccb4\ub97c \uc900\ube44\ud558\ub294 \uc791\uc5c5\uc744 \uc5d8\ub9ac\uc5b8\uc5d0\uac8c \ub9e1\uacbc\ub2e4. \ud478\ub9b0\uc740 \ub2e8\uc21c\ud55c \uc720\uae30 \ubd84\uc790\uc778\ub370, DNA\uc758 \ub124 \uac1c \uc5fc\uae30 \uc911 \ub450 \uac1c\ub294 \ud478\ub9b0 \uc720\ub3c4\uccb4(\ub2e4\ub978 \ub450 \uac1c\ub294 \ud53c\ub9ac\ubbf8\ub518 \uc720\ub3c4\uccb4)\ub2e4. \ud478\ub9b0 \uadf8 \uc790\uccb4\ub294 5\ud658 \uace0\ub9ac\uc640 \uc735\ud569\ub41c 6\ud658 \uace0\ub9ac\ub85c \uc774\ub8e8\uc5b4\uc838 \uc788\ub2e4.<\/p>\n

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\ud478\ub9b0\uc758 \uad6c\uc870<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\uadf8\ub140\uac00 \ud574\uc57c \ud560 \uc77c\uc740 \ud658\uc790\ub4e4\uc5d0\uac8c \ud22c\uc5ec\ud558\uc5ec \ubc15\ud14c\ub9ac\uc544, \uae30\uc0dd\ucda9 \ub610\ub294 \uc885\uc591 \uc138\ud3ec\ub97c \uc18d\uc77c \uc218 \uc788\ub3c4\ub85d \uc774 \ubd84\uc790\uc758 \ub2e4\uc591\ud55c \uc720\ub3c4\uccb4\ub97c \uc900\ube44\ud558\ub294 \uac83\uc774\uc5c8\ub2e4. \uc5d8\ub9ac\uc5b8\uc740 \uc77c\uc744 \ud560 \ub54c \ud788\uce6d\uc2a4\ucc98\ub7fc \uc5f4\uc815\uc801\uc774\uc5c8\ub2e4. \uc720\uae30\ud569\uc131 \uc791\uc5c5\uc744 \uc140 \uc218 \uc5c6\uc744 \ub9cc\ud07c \uc218\ud589\ud588\uc744 \ubfd0\ub9cc \uc544\ub2c8\ub77c \uadf8\uc640 \uad00\ub828\ub41c \ubd84\uc57c\ub97c \uc2b5\ub4dd\ud574\uc11c \uc0c8\ub85c\uc6b4 \ubb3c\uc9c8\uc758 \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc744 \ud14c\uc2a4\ud2b8\ud588\ub2e4.<\/p>\n

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“\uc774\ubd10… \ubc15\ud14c\ub9ac\uc544, \uae30\uc0dd\ucda9, \uc885\uc591 \uc138\ud3ec\ub97c \uc18d\uc774\ub77c\ub2c8\uae4c… \ub2c8\uac00 \uc18d\uc73c\uba74 \uc5b4\ucf00\ud574…”<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\ud798\ub4e0 \uc77c\uc774 \uacb0\uc2e4\uc744 \ub0b3\uc558\ub2e4. 30\uc5ec \ub144 \ub3d9\uc548 \uacf5\ub3d9 \uc791\uc5c5\uc744 \ud558\uba74\uc11c, \ub450 \uc0ac\ub78c\uc740 \ub9ce\uc740 \uc57d\uc744 \uac1c\ubc1c\ud588\ub294\ub370, \ubaa8\ub450 \ud478\ub9b0 \uc720\ub3c4\uccb4\uc600\ub2e4. \uc798 \uc54c\ub824\uc9c4 \uac83\ub4e4\uc740 \ub2e4\uc74c\uacfc \uac19\ub2e4.<\/p>\n

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\u25cf \ud2f0\uc624\uad6c\uc544\ub2cc Thioguanine: \uc18c\uc544 \ubc31\ud608\ubcd1 \uce58\ub8cc\uc81c
\n\u25cf \ud478\ub9ac\ub124\ud1a8 Purinethol(\uba54\ub974\uce85\ud1a0\ud478\ub9b0 mercaptopurine):
\n\ubc31\ud608\ubcd1, \ube44\u975e\ud638\uc9c0\ud0a8 \ub9bc\ud504\uc885 \ubc0f \uae30\ud0c0 \uc9c8\ubcd1 \uce58\ub8cc\uc81c
\n\u25cf \uc9c8\ub85c\ud504\ub9bc Zyloprim(\uc54c\ub85c\ud478\ub9ac\ub180 Allopurinol):
\n\ud1b5\ud48d \uce58\ub8cc\uc5d0 \uac00\uc7a5 \uc911\uc694\ud55c \uae30\ub2a5\uc744 \ud558\ub294 \uc57d
\n\u25cf \uc774\ubb34\ub780 Imuran(\uc544\uc790\ud2f0\uc624\ud504\ub9b0 Azathioprine):
\n\uc7a5\uae30\uc774\uc2dd \ub54c \uc774\uc2dd \uae30\uad00\uc758 \uac70\ubd80\ub97c \ub9c9\ub294 \uba74\uc5ed \uc5b5\uc81c\uc81c
\n\u25cf \uc870\ube44\ub77d\uc2a4 Zovirax(\uc544\uc2dc\ud074\ub85c\ube44\ub974 Acyclovir):
\n\ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c(\uc608: \ud5e4\ub974\ud398\uc2a4 \uc774\ub7ec\uc2a4 herpes virus \uac10\uc5fc \uce58\ub8cc\uc5d0 \uc0ac\uc6a9)<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc644\uc804\ud788 \uc0c8\ub85c\uc6b4 \uc57d\uc774 \uc2dc\ud310\ub418\ub294 \uacbd\uc6b0\ub294 \uac70\uc758 \uc5c6\ub294\ub370, \uc5ec\uae30\uc11c\ub294 \uc804\uccb4\uc5d0\uc11c \ub208\uc5d0 \ub744\ub294 \uba87 \uac00\uc9c0 \ubaa9\ub85d\ub9cc \uc81c\uc2dc\ud588\ub2e4. \uadf8\ub7ec\ub098 \uc5d8\ub9ac\uc5b8, \uadf8\ub9ac\uace0 \uadf8\ub140\uc640 \ud568\uaed8 \ub178\ubca8\uc0c1\uc744 \uacf5\ub3d9\uc73c\ub85c \ubc1b\uc740 \ub3d9\ub8cc\ub4e4\uc740 \ud2b9\uc815 \uc57d\ud488\uc758 \ubc1c\uacac\uc774 \uc544\ub2c8\ub77c \uc57d\ud488 \uc5f0\uad6c\ub97c \uc704\ud574 \uc218\ub9bd\ud55c \uc6d0\ub9ac\ub97c \uc778\uc815\ubc1b\uc544\uc11c \uc0c1\uc744 \ubc1b\uc558\ub2e4. \ub178\ubca8\uc0c1\uc5d0 \uc5b8\uae09\ub41c \uadf8 \uc6d0\ub9ac\ub294 \u2018\ud569\ub9ac\uc801\uc778 \uc57d\ud488 \uc124\uacc4\u2019\ub77c\ub294 \uac83\uc774\ub2e4. \uc774 \uc544\uc774\ub514\uc5b4\ub294 \uc6d0\ub798 \ud788\uce6d\uc2a4\uc758 \ucd08\uae30 DNA \uc5f0\uad6c\uc5d0\uc11c \ub098\uc654\ub2e4.<\/p>\n

\uc774\ub7f0 \uc131\uacf5\uc5d0\ub3c4, \uc5d8\ub9ac\uc5b8\uc740 \uc790\uae30\uac00 \ubc15\uc0ac\ud559\uc704\uac00 \uc5c6\ub2e4\ub294 \uc810\uc744 \ub298 \uc544\uc26c\uc6cc\ud588\ub2e4. \uadf8\ub140\ub294 \ubc15\uc0ac\ud559\uc704\uac00 \uc5c6\ub294 \uba87\uba87 \ub178\ubca8\uc0c1 \uc218\uc0c1\uc790 \uc911 \ud55c \uba85\uc774\uc5c8\ub2e4. \uc2e4\uc81c\ub85c, \uadf8\ub140\ub294 \ud604\uc5ed \uc2dc\uc808 \ud55c\ub54c \ubc15\uc0ac\ud559\uc704\ub97c \ucde8\ub4dd\ud558\ub824\uace0 \ube0c\ub8e8\ud074\ub9b0 \ud3f4\ub9ac\ud14c\ud06c\uc5f0\uad6c\uc18c\uc5d0 \ub4f1\ub85d\ud558\uae30\ub85c \ub9c8\uc74c\uba39\uc740 \uc801\uc774 \uc788\uc5c8\ub2e4. \uadf8\ub7ec\ub098 \uc5bc\ub9c8 \uc9c0\ub098\uc9c0 \uc54a\uc544 \uc0c1\uadfc\uc9c1\ub9cc \uacf5\ubd80\ub97c \uacc4\uc18d\ud560 \uc218 \uc788\ub2e4\ub294 \ub9d0\uc744 \ub4e4\uc5c8\ub2e4. \uc774 \ub9d0\uc740 \uadf8\ub140\uac00 \uc88b\uc544\ud558\uace0 \ud544\uc694\ub85c \ud558\ub294 \uc77c\uc744 \ud3ec\uae30\ud558\ub77c\ub294 \uac83\uc774\ub098 \ub2e4\ub984\uc5c6\uc5c8\ub2e4. \ud558\uc9c0\ub9cc \uadf8\ub140\ub294 \ud3ec\uae30\ud558\uc9c0 \uc54a\uc558\ub2e4. \ub098\uc911\uc5d0 \uc131\uacf5\ud55c \uc774\ud6c4, \uadf8\ub140\ub294 \uba87 \uad70\ub370\ub85c\ubd80\ud130 \uba85\uc608 \ubc15\uc0ac\ud559\uc704\ub97c \ubc1b\uc558\ub294\ub370, \uadf8\uc911\uc758 \ud558\ub098\uac00 \ube0c\ub8e8\ud074\ub9b0 \ud3f4\ub9ac\ud14c\ud06c\uc5f0\uad6c\uc18c\uc600\ub2e4.<\/p>\n

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1969\ub144, \uac70\ud2b8\ub8e8\ub4dc \uc5d8\ub9ac\uc5b8\uc774 \uc870\uc9c0\uc6cc\uc2f1\ud134 \ub300\ud559\uad50\uc5d0\uc11c \uccab \uba85\uc608 \ubc15\uc0ac\ud559\uc704\ub97c \ubc1b\uc558\uc744 \ub54c \uc870\uc9c0 \ud788\uce6d\uc2a4\uc640 \ud568\uaed8 (\u6545 \uac70\ud2b8\ub8e8\ub4dc \uc5d8\ub9ac\uc5b8 \uc81c\uacf5)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\uc5d8\ub9ac\uc5b8\uc740 \uc0dd\uc560 \ub9c8\uc9c0\ub9c9\uae4c\uc9c0 \uc655\uc131\ud558\uac8c \ud65c\ub3d9\ud588\ub2e4. 1996\ub144\uc5d0 \ub0a8\ud3b8\uacfc \ub098\ub294 \ub9ac\uc11c\uce58 \ud2b8\ub77c\uc774\uc575\uae00 \ud30c\ud06c\uc5d0 \uc704\uce58\ud55c \uadf8\ub140\uc758 \uc0ac\ubb34\uc2e4\uc744 \ubc29\ubb38\ud588\ub2e4. \uc0ac\ubb34\uc2e4 \ubcbd\uc5d0\ub294 \uc0ac\uc9c4\uc774 \ub9ce\uc774 \uac78\ub824 \uc788\uc5c8\ub2e4. \ubaa8\ub450 \uadf8\ub140\uc758 \ub3d9\ub8cc \ubc0f \uc5c5\ubb34\uc640 \uad00\ub828\ub41c \uc0ac\uc9c4\uc774\uc5c8\ub2e4. \uadf8\uc911 \uc601\uad6d \ud48d\uc790\ub9cc\ud654\uac00 \uc81c\uc784\uc2a4 \uae38\ub808\uc774James Gillray<\/sub>\uac00 \uadf8\ub9b0 \u3008\ud1b5\ud48dThe Gout<\/sub>\u3009 \uc0ac\ubcf8\uc774 \uc561\uc790\ub85c \ud45c\uad6c\ub418\uc5b4 \uc788\uc5c8\ub2e4.<\/p>\n

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\uc81c\uc784\uc2a4 \uae38\ub808\uc774 \u3008\ud1b5\ud48d\u3009<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\ud1b5\ud48d\uc740 \uad00\uc808 \ud1b5\uc99d\uc744 \ud638\uc18c\ud558\ub294 \ubd88\ucf8c\ud55c \uc9c8\ud658\uc778\ub370, \ub300\uac1c \uc5c4\uc9c0\ubc1c\uac00\ub77d\uc5d0\uc11c \ubc1c\uc0dd\ud55c\ub2e4. \ud608\uc561 \uc548\uc5d0 \uc694\uc0b0\uc774 \ub108\ubb34 \ub9ce\uc544 \uc694\uc0b0 \uacb0\uc815\uccb4\uac00 \ud615\uc131\ub418\uace0 \uc774\uac83\uc774 \uad00\uc808\uc5d0 \ucd95\uc801\ub418\uc5b4 \ubc1c\uc0dd\ud558\uba70 \uc5fc\uc99d\uc744 \uc720\ubc1c\ud55c\ub2e4. \uc694\uc0b0\uc740 \ud478\ub9b0 \ub300\uc0ac \uacfc\uc815\uc758 \ubd80\uc0b0\ubb3c\uc778\ub370, \ud478\ub9b0\uc758 \ud654\ud559\uc801 \ud2b9\uc131\uc744 \uaddc\uba85\ud558\ub294 \uac83\uc740 \uc5d8\ub9ac\uc5b8\uc758 \ud575\uc2ec \uc5f0\uad6c\uc600\ub2e4. \uadf8\ub140\uc640 \ub3d9\ub8cc\ub4e4\uc774 \ud1b5\ud48d \uce58\ub8cc\uc81c\ub97c \ubc1c\uacac\ud55c \uac83\uc740 \uac70\uc758 \uc6b0\uc5f0\uc5d0 \uac00\uae4c\uc6e0\ub2e4. \uc774 \uc57d \ub355\ubd84\uc5d0 \ud68c\uc0ac\ub294 \uc218\uc775\uc774 \ub9ce\uc774 \uc0dd\uacbc\ub294\ub370, \uc608\uae30\uce58 \uc54a\uc740 \uc131\uacf5\uc774\uc5c8\ub2e4. \uadf8\ub4e4\uc758 \ub178\ub825\uc774 \uc218\uc775 \ucc3d\ucd9c\uc744 \ubc14\ub77c\uace0 \uc9c0\uc2dc\ub97c \ubc1b\uc544 \ud55c \uac83\uc774 \uc544\ub2c8\uc5c8\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n

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\uc9c8\ubcd1\uc5d0\uc11c \uace0\ud1b5\ubc1b\ub294 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc744 \uad6c\ud55c \uc9c4\uc815\ud55c \uc601\uc6c5<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc5d8\ub9ac\uc5b8\uc740 81\uc138\ub97c \uc77c\uae30\ub85c 1999\ub144\uc5d0 \uc0ac\ub9dd\ud588\ub2e4. \uadf8\ub140\ub294 \uacb0\ud63c\ud558\uc9c0 \uc54a\uc558\ub2e4. \uadf8\ub140\ub294 \uae09\uc131 \uc9c8\ud658, \uc989 \uc2ec\uc7a5 \uac10\uc5fc\uc73c\ub85c \uc0ac\ub9dd\ud55c \uc57d\ud63c\uc790\ub97c \uc5b4\ub290 \ub204\uad6c\ub3c4 \ub300\uc2e0\ud560 \uc218 \uc5c6\ub2e4\uace0 \uc0dd\uac01\ud588\ub2e4. \uadf8\ub140\ub294 \ub9c8\uc9c0\ub9c9 \ub0a0\uae4c\uc9c0 \ud65c\ubc1c\ud558\uac8c \ud65c\ub3d9\ud588\ub294\ub370, \ud558\ub824\ub358 \uacc4\ud68d\uc774 \uc544\uc8fc \ub9ce\uc558\ub2e4. \uc5d8\ub9ac\uc5b8\uc740 \uadf8 \uc774\uc720\ub97c \uc774\ub807\uac8c \ub9d0\ud588\ub2e4.<\/p>\n

\u201c\uc544\uc9c1 \ud560 \uc77c\uc774 \ub108\ubb34 \ub9ce\uc544\uc694. \uac00\uce58 \uc788\ub294 \uc5f0\uad6c\ub294 \uc815\ub9d0\ub85c \ubcc0\ud654\ub97c\u00a0<\/b>\ubd88\ub7ec\uc62c \uc218 \uc788\ub2f5\ub2c8\ub2e4. \ub0b4\uac00 \uc5b4\ub518\uac00\uc5d0\uc11c \uac15\uc758\ub97c \ud588\ub294\ub370 \ub204\uad70\uac00 \ub0b4\uac8c \uc640<\/b>\uc11c \u2018\ub2f9\uc2e0 \ub355\ubd84\uc5d0 \uc2e0\uc7a5 \uc774\uc2dd\uc744 \ud588\uace0 25\ub144\uc774 \uc9c0\ub0ac\uc2b5\ub2c8\ub2e4\u2019\ub77c\uace0 \ud588\uc744 \ub54c \ub0b4<\/b>\uac00 \uc5b4\ub5bb\uac8c \ub290\uaf08\uc744\uc9c0 \uc0c1\uc0c1\ud574\ubcf4\uc138\uc694. \ub098\ub294 \u2018\uac10\uc0ac\u2019 \ud3b8\uc9c0\ub97c \ub9ce\uc774 \ubc1b\uc558\ub294\ub370,\u00a0<\/b>\uc774\ub4e4\uc744 \ubaa8\ub450 \uac00\uc9c0\uace0 \uc788\uc5b4\uc694. \uadf8\ub7f0 \ud3b8\uc9c0\ub4e4\uc774\uc57c\ub9d0\ub85c \uc544\ud508 \uc0ac\ub78c\ub4e4\uc744 \uac74\uac15\ud558\uac8c \ud55c \uac83\uc5d0 \ub300\ud55c \uc9c4\uc815\ud55c \ubcf4\uc0c1\uc774 \uc544\ub2d0\uae4c\uc694.”<\/b><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n

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 <\/p>\n","protected":false},"excerpt":{"rendered":"

    \uac70\ud2b8\ub8e8\ub4dc B. \uc5d8\ub9ac\uc5b8 Gertrude B. Elion \ud654\ud559\uc790, \uc57d\ub9ac\ud559\uc790    1996\ub144, \ub178\uc2a4\uce90\ub864\ub77c\uc774\ub098 \ub9ac\uc11c\uce58 \ud2b8\ub77c\uc774\uc575\uae00 \ud30c\ud06c\uc5d0\uc11c \uac70\ud2b8\ub8e8\ub4dc \uc5d8\ub9ac\uc5b8\uacfc \ub9c9\ub2ec\ub808\ub098 \ud5c8\uae30\ud0c0\uc774 (\uc0ac\uc9c4: \uc774\uc2a4\ud2b8\ubc18 \ud5c8\uae30\ud0c0\uc774)    (more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[41,38,34,29,47],"tags":[],"class_list":["post-4673","post","type-post","status-publish","format-standard","hentry","category-05---","category-38","category-lets-do-chemistry","category-lets-do-science","category-47"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t