{"id":4523,"date":"2019-10-23T13:33:58","date_gmt":"2019-10-23T04:33:58","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=4523"},"modified":"2019-10-23T13:33:58","modified_gmt":"2019-10-23T04:33:58","slug":"%eb%b0%94%ec%9d%b4%eb%9f%ac%ec%8a%a4-%eb%b2%a1%ed%84%b0-%ec%9c%a0%ec%a0%84%ec%9e%90%ec%b9%98%eb%a3%8c-%ec%8b%9c%eb%8c%80-%ec%83%88-%e7%ab%a0%ec%9d%84-%ec%97%b4%eb%8b%a4","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4523","title":{"rendered":"\ubc14\uc774\ub7ec\uc2a4 \ubca1\ud130, \uc720\uc804\uc790\uce58\ub8cc \uc2dc\ub300 \uc0c8 \u7ae0\uc744 \uc5f4\ub2e4"},"content":{"rendered":"

 <\/p>\n

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\uc720\uc804\uc790\uc804\ub2ec \ud6a8\uc728\uc131 \uae30\ubc18 \ub2e4\uc591\ud55c \uc9c8\ud658 \ud0c0\uae43 \uc2dc\ud5d8<\/p>\n

\ub80c\ud2f0\ubc14\uc774\ub7ec\uc2a4 \uc6a9\uc774\ud558\uac8c\u00a0SIN<\/span>\u00a0\ub514\uc790\uc778 \ub3c4\uc785 \uac00\ub2a5<\/p>\n

\uc138\uacc4 \uc758\uc57d\ud488 \uc2dc\uc7a5 2025\ub144\uae4c\uc9c0 \ub9e4\ub144 20\uac1c \uc2b9\uc778<\/p>\n

\uc720\uc804\uc790\uce58\ub8cc\uc81c \uc5f0\uad6c\uac1c\ubc1c \uacb0\uc2e4 \ub9fa\ub294 \uc2dc\uae30 \uc804\ub9dd<\/b><\/p>\n

 <\/p>\n

<\/b><\/p>\n

\"\"<\/span><\/p>\n

\uc720\uc804\uc790\uce58\ub8cc\uc758 \ud575\uc2ec \uae30\uc220\ub3c4\uad6c.\u00a0Dunbar<\/span>\u00a0et<\/span>\u00a0al.,<\/span>\u00a0Science<\/span>\u00a0359, 175 (2018). \uc790\ub8cc: \uc0dd\uba85\uacf5\ud559\uc815\ucc45\uc5f0\uad6c\uc13c\ud130<\/em><\/span><\/p>\n

 <\/p>\n

\"\"<\/span><\/p>\n

\ubbf8\uad6d \uc720\uc804\uc790\uc138\ud3ec\uce58\ub8cc\ud559\ud68c \ubc1c\ud45c\ucd08\ub85d \ud0a4\uc6cc\ub4dc \ubd84\uc11d\uc744 \ud1b5\ud55c \uc8fc\uc694\uae30\uc220 \uc870\uc0ac. \uc0dd\uba85\uacf5\ud559\uc815\ucc45\uc5f0\uad6c\uc13c\ud130 \uc81c\uacf5<\/em><\/span><\/p>\n

 <\/p>\n

 <\/p>\n

‘\ubc14\uc774\ub7ec\uc2a4 \ubca1\ud130’\ub4e4\uc758 \uac1c\ubc1c\uacfc \ud568\uaed8 \uc720\uc804\uc790\uce58\ub8cc \uc2dc\ub300\uac00 \ubcf8\uaca9\ud654\ud558\uace0 \uc788\ub2e4.<\/p>\n

21\uc77c \ubc14\uc774\uc624\uc5c5\uacc4\uc5d0 \ub530\ub974\uba74, \uc778\uccb4 \uc138\ud3ec \ub0b4\ub85c \uc720\uc804\uc790\ub97c \uc804\ub2ec\ud560 \uc218 \uc788\ub294 \ubc14\uc774\ub7ec\uc2a4 \ubca1\ud130\uc758 \uac1c\ubc1c\uc774 \uc720\uc804\uc790\uce58\ub8cc\uc758 \uc2e4\ud604 \uac00\ub2a5\uc131\uc744 \ub192\uc774\uace0 \uc788\ub2e4.<\/p>\n

\ucc28\uc138\ub300 \ubc14\uc774\uc624\uc758\ud559 \uae30\uc220\ub85c \uaf3d\ud788\ub294 \uc720\uc804\uc790\uce58\ub8cc\ub294 \uc720\uc804\ubb3c\uc9c8\uc774\ub098 \uc720\uc804\ubb3c\uc9c8\uc744 \uc774\uc785\ud55c \uc138\ud3ec\ub97c \uc778\uccb4\uc5d0 \ud22c\uc5ec\ud574 \uc9c8\ubcd1\uc744 \uce58\ub8cc\ud558\uac70\ub098 \uc608\ubc29\ud560 \uc218 \uc788\ub294 \uce58\ub8cc\uae30\uc220\uc774\ub2e4.<\/p>\n

\uc720\uc804\uc790\uce58\ub8cc\uc81c\uc758 \uacbd\uc6b0, 2012\ub144\ubd80\ud130 \uc720\ub7fd\uacfc \ubbf8\uad6d\uc5d0\uc11c \ud488\ubaa9\ud5c8\uac00\ub97c \ubc1b\uae30 \uc2dc\uc791\ud574 \uc9c0\ub09c 2017\ub144 \ubbf8\uad6d\uc5d0\uc11c 3\uc885\uc758 \uc720\uc804\uc790\uce58\ub8cc\uc81c(2\uc885\uc758 \ud608\uc561\uc554 \uc720\uc804\uc790\uce58\ub8cc\uc81c \ubc0f 1\uc885\uc758 \uc2e4\uba85 \uc720\uc804\uc790\uce58\ub8cc\uc81c)\uac00 \ubbf8\uad6d\u00a0FDA<\/span>(\uc2dd\ud488\uc758\uc57d\uad6d)\ub85c\ubd80\ud130 \ud488\ubaa9\ud5c8\uac00\ub97c \ubc1b\uace0, 2018\ub144 \uc218\ud3ec\uc131 \ud45c\ud53c \ubc15\ub9ac\uc99d \uc720\uc804\uc790\uce58\ub8cc\uc81c\uac00 \ud76c\uadc0\uc9c8\ud658\uc758\uc57d\ud488\uc73c\ub85c \uc9c0\uc815 \ubc1b\ub294 \ub4f1 \uc5f0\uad6c\uac1c\ubc1c\uc758 \uc131\uacfc\uac00 \uac00\uc2dc\uc801\uc73c\ub85c \ub098\ud0c0\ub098\uace0 \uc788\ub2e4.<\/p>\n

\uad6d\ub0b4\uc5d0\uc11c\ub294 \uc2dd\ud488\uc758\uc57d\ud488\uc548\uc804\ucc98\ub85c\ubd80\ud130 \ud488\ubaa9\ud5c8\uac00\ub97c \ubc1b\uc558\ub358 \uc720\uc77c\ud55c \ud1a0\uc885 \uc720\uc804\uc790\uce58\ub8cc\uc81c\ub85c \ucf54\uc624\ub871\uc0dd\uba85\uacfc\ud559\uc758 ‘\uc778\ubcf4\uc0ac\ucf00\uc774\uc8fc’\uac00 \uc788\uc5c8\uc9c0\ub9cc \ud5c8\uac00\ubc1b\uc740 \uac83\uacfc \ub2e4\ub978 \uc131\ubd84\uc774 \uc8fc\uc131\ubd84\uc73c\ub85c \uc4f0\uc5ec \uc9c0\ub09c 7\uc6d4 \ud488\ubaa9\ud5c8\uac00 \ucde8\uc18c \ucc98\ubd84\uc774 \ud655\uc815\ub41c \ubc14 \uc788\ub2e4. \uc778\ubcf4\uc0ac\ub294 2017\ub144 \uad6d\ub0b4 \uccab \uc720\uc804\uc790 \uce58\ub8cc\uc81c\ub85c \ud5c8\uac00\ubc1b\uc558\uc73c\ub098 \uc8fc\uc131\ubd84 \uc911 \ud558\ub098\uac00 \ud5c8\uac00 \ub2f9\uc2dc \uc81c\ucd9c\ud55c \uc790\ub8cc\uc5d0 \uae30\uc7ac\ub41c \uc5f0\uace8\uc138\ud3ec\uac00 \uc544\ub2cc \uc885\uc591 \uc720\ubc1c \uac00\ub2a5\uc131\uc774 \uc788\ub294 \uc2e0\uc7a5\uc138\ud3ec(293\uc720\ub798\uc138\ud3ec)\ub85c \ub4a4\ub2a6\uac8c \ub4dc\ub7ec\ub0ac\ub2e4.<\/p>\n

\uadf8\ub7ec\ub098 \uc138\uacc4 \uc758\uc57d\ud488 \uc2dc\uc7a5\uc5d0\uc11c\ub294 2025\ub144\uae4c\uc9c0 \ub9e4\ub144 20\uac1c\uc758 \uc138\ud3ec \uc720\uc804\uc790\uce58\ub8cc\uc81c\uac00 \uc2b9\uc778\ub418\uba74\uc11c, \uc720\uc804\uc790\uce58\ub8cc\uc81c \uc5f0\uad6c\uac1c\ubc1c\uc774 \uacb0\uc2e4\uc744 \ub9fa\ub294 \uc2dc\uae30\ub85c \uae30\ub85d\ub420 \uac83\uc774\ub77c\ub294 \uc804\ub9dd\uc774\ub2e4.<\/p>\n

\uc2e4\uc81c\ub85c \uc62c\ucd08\u00a0FDA<\/span>\u00a0\uc2a4\ucf67 \uace0\ud2c0\ub9bd \uad6d\uc7a5\uacfc \ud53c\ud130 \ub9c8\ud06c\u00a0CBER<\/span>(\uc0dd\ubb3c\uc81c\uc81c\ud3c9\uac00\uc5f0\uad6c\uc13c\ud130) \uc13c\ud130\uc7a5\uc774 \uc131\uba85\uc11c\ub97c \ud1b5\ud574 \uacf5\uac1c\ud55c \uc138\ud3ec \uc720\uc804\uc790 \uce58\ub8cc\uc81c \uc815\ucc45 \ub85c\ub4dc\ub9f5\uc744 \ubcf4\uba74,\u00a0FDA<\/span>\ub294 2020\ub144\uae4c\uc9c0 \ud65c\uc131 \uc138\ud3ec \uae30\ubc18 \ub610\ub294 \uc9c1\uc811 \ud22c\uc5ec\ud558\ub294 \uc720\uc804\uc790 \uce58\ub8cc\uc81c\ub85c \ub9e4\ub144 200\uac1c \uc774\uc0c1\uc758\u00a0IND<\/span>(\uc784\uc0c1\uc2dc\ud5d8 \uacc4\ud68d \uc2b9\uc778) \uc2e0\uccad\uc11c\uac00 \uc811\uc218\ub420 \uac83\uc73c\ub85c \uc608\uc0c1\ud558\uace0 \uc788\ub2e4. \ub610\ud55c \uc9c0\uae08\uae4c\uc9c0\uc758 \uc138\ud3ec \uc720\uc804\uc790\uce58\ub8cc\uc81c\uc758 \uc784\uc0c1\uc2dc\ud5d8 \uc131\uacf5\ub960\ub85c \ubd24\uc744 \ub54c \uc624\ub294 2025\ub144\uae4c\uc9c0 \ub9e4\ub144 10~20\uac1c \uc138\ud3ec \uc720\uc804\uc790 \uce58\ub8cc\uc81c\uc5d0 \ub300\ud55c \uc2b9\uc778\uc774 \uc774\ub904\uc9c8 \uac83\uc774\ub77c\ub294 \uc804\ub9dd\uc774\ub2e4.<\/p>\n

\ud2b9\ud788 \uc774\ub7ec\ud55c \uc720\uc804\uc790\uce58\ub8cc\uc81c\uac00 \uc6b0\uc218\ud55c \uce58\ub8cc\ud6a8\uacfc\ub97c \ub0bc \uc218 \uc788\ub3c4\ub85d \ud558\ub294\ub370 \ud575\uc2ec\uc801\uc778 \uc5ed\ud560\uc744 \ud558\ub294 \uc694\uc18c\ub85c, \ubc14\uc774\ub7ec\uc2a4 \ubca1\ud130(\uc6b4\ubc18\uccb4) \uac1c\ubc1c\uc774 \uc8fc\ubaa9\ubc1b\uace0 \uc788\ub2e4.<\/p>\n

\uc0dd\uba85\uacf5\ud559\uc815\ucc45\uc5f0\uad6c\uc13c\ud130\uc758 ‘\ubc14\uc774\uc624\uc778\ud504\ub85c’\uc5d0 \uac8c\uc7ac\ub41c ‘\uc720\uc804\uc790\uce58\ub8cc\uc758 \ud604\uc8fc\uc18c(\uae40\uc5f0\uc218 \ucda9\ub0a8\ub300\ud559\uad50 \uc2e0\uc57d\uc804\ubb38\ub300\ud559\uc6d0 \uad50\uc218\u00b7\uc720\uc2b9\uc2e0 \ubc14\uc774\ub85c\uba54\ub4dc \uc2e0\uc0ac\uc5c5\uae30\ud68d\ubcf8\ubd80\uc7a5)’ \ubcf4\uace0\uc11c\ub97c \ubcf4\uba74, \uc720\uc804\uc790\uce58\ub8cc\ud559\ud68c\uc778\u00a0ASGCT<\/span>(\ubbf8\uad6d \uc720\uc804\uc790\uc138\ud3ec\uce58\ub8cc\ud559\ud68c)\uc5d0\uc11c \ubc1c\ud45c\ub418\ub294 \ucd5c\uadfc\uc758 \uc5f0\uad6c\uacb0\uacfc\ub97c \ubd84\uc11d\ud55c \uacb0\uacfc,\u00a0AAV<\/span>(adeno-associated<\/span>\u00a0virus<\/span>) \ubca1\ud130\uc640 \ub808\ud2b8\ub85c\ubc14\uc774\ub7ec\uc2a4\uc758 \uc77c\uc885\uc778 \ub80c\ud2f0\ubc14\uc774\ub7ec\uc2a4 \ubca1\ud130 \uae30\uc220\uc744 \uc0ac\uc6a9\ud558\ub294 \uc5f0\uad6c\uac1c\ubc1c\uc774 \uc8fc\ub958\ub97c \uc774\ub8e8\uace0 \uc788\ub2e4.<\/p>\n

\uc2e4\uc81c\ub85c 2017\ub144\u00a0ASGCT<\/span>\u00a0\ubc1c\ud45c\ucd08\ub85d \ud0a4\uc6cc\ub4dc \ubd84\uc11d\uc744 \ud1b5\ud574 \uc8fc\uc694 \uae30\uc220\uc744 \uc870\uc0ac\ud55c \uacb0\uacfc, \uc804\uccb4 \ubc1c\ud45c\ucd08\ub85d \uc911 40.3%(316\uac74)\uac00\u00a0AAV<\/span>\u00a0\ubca1\ud130, 15.3%(120\uac74)\uac00 \ub80c\ud2f0\ubc14\uc774\ub7ec\uc2a4 \ubca1\ud130\uc600\ub2e4.<\/p>\n

\ubc14\uc774\ub7ec\uc2a4 \ubca1\ud130\uc758 \uc911\uc694\uc131\uc740 1980\ub144 \uc7ac\uc870\ud569\u00a0DNA<\/span>\u00a0\uae30\uc220\uc744 \uc9c4\ud575\uc138\ud3ec\ub97c \ub300\uc0c1\uc73c\ub85c \uc2e4\ud604\ud574 \ub178\ubca8\uc0c1\uc744 \uc218\uc0c1\ud55c \ud3f4 \ubc84\uadf8 \ubc15\uc0ac\uc758 \uc218\uc0c1\uc5f0\uc124\uc5d0\uc11c \uc5b8\uae09\ub418\uae30\ub3c4 \ud588\ub2e4. \ub2f9\uc2dc \uadf8\ub294 \uc778\uccb4 \uc138\ud3ec \ub0b4\ub85c \uc720\uc804\uc790\ub97c \uc804\ub2ec\ud560 \uc218 \uc788\ub294 \ubc14\uc774\ub7ec\uc2a4 \ubca1\ud130\uc758 \uac1c\ubc1c\uc5d0 \ub530\ub978 \uc720\uc804\uc790\uce58\ub8cc\uc758 \uc2e4\ud604 \uac00\ub2a5\uc131\uc5d0 \ub300\ud574 \uac15\uc870\ud588\ub2e4.<\/p>\n

\ub808\ud2b8\ub85c\ubc14\uc774\ub7ec\uc2a4\uc758 \uc77c\uc885\uc778 \ub80c\ud2f0\ubc14\uc774\ub7ec\uc2a4\ub294 \uc138\ud3ec\ubd84\uc5f4\uacfc \uad00\uacc4\uc5c6\uc774 \uc720\uc804\uc790 \uc804\ub2ec\uc774 \uac00\ub2a5\ud558\uba70, \uc0bd\uc785\ub418\ub294 \uc5fc\uc0c9\uccb4\uc758 \uc704\uce58\uac00 \ube44\uad50\uc801\u00a0‘oncogenic<\/span>\u00a0insertional<\/span>\u00a0mutagenesis<\/span>(\uc885\uc591 \uc0bd\uc785 \ub3cc\uc5f0\ubcc0\uc774 \ubc1c\uc0dd)’\uc758 \uc704\ud5d8\uc131\uc774 \ub0ae\uc740 \uacf3\uc5d0 \ubd84\ud3ec\ud558\uace0, \ube44\uad50\uc801 \uc6a9\uc774\ud558\uac8c\u00a0SIN<\/span>\u00a0(\uc790\uae30 \ud65c\uc131\ud654) \ub514\uc790\uc778\uc744 \ub3c4\uc785\ud574 \uc704\ud5d8\uc131\uc744 \uc6d0\ucc9c \ucc28\ub2e8\ud560 \uc218 \uc788\ub2e4.<\/p>\n

\ub610\ud55c\u00a0AAV<\/span>\u00a0\ubca1\ud130\uc758 \uacbd\uc6b0, \ub2e4\uc591\ud55c \uc0dd\uccb4 \uc7a5\uae30\ub85c\uc758 \ub192\uc740 \uac10\uc5fc\ud6a8\uc728\uacfc \uc804\ub2ec\ub41c \uc720\uc804\uc790\uc758 \uc7a5\uae30\uac04 \ubc1c\ud604\uc774 \uc7a5\uc810\uc73c\ub85c \uaf3d\ud788\uba70, \ub9ce\uc740 \uc720\uc804\uc131\u00b7\ud1f4\ud589\uc131 \uc9c8\ud658\uc758 \uce58\ub8cc\ub97c \uc704\ud55c\u00a0in<\/span>\u00a0vivo<\/span>(\uc0dd\uccb4 \ub0b4) \uc720\uc804\uc790\uce58\ub8cc\uc758 \ud575\uc2ec \uc720\uc804\uc790 \uc804\ub2ec \ubca1\ud130\ub85c \uac01\uad11 \ubc1b\uace0 \uc788\ub2e4. \ucd5c\uadfc\uc5d0\ub294 \uc778\uccb4 \ub1cc\uc5d0 \uc874\uc7ac\ud558\ub294\u00a0BBB<\/span>(Brain<\/span>\u00a0Blood<\/span>\u00a0Barrier<\/span>) \ud22c\uacfc\uc131\uc744 \ub192\uc774\uae30 \uc704\ud55c\u00a0AAV<\/span>\u00a0\ubca1\ud130 \uc5f0\uad6c\uac00 \uac00\uc2dc\uc801\uc778 \uc131\uacfc\ub97c \ub0b4\uace0 \uc788\ub2e4. \ub9dd\ub9c9\uc2e0\uacbd\uc138\ud3ec, \uac04, \uc911\ucd94\uc2e0\uacbd\uacc4, \uadfc\uc721 \ub4f1 \ub2e4\uc591\ud55c \uc7a5\uae30\uc870\uc9c1\uc744 \ud0c0\uae43\uc73c\ub85c, \uc6b0\uc218\ud55c\u00a0AAV<\/span>\u00a0\ubca1\ud130 \uc720\uc804\uc790\uc804\ub2ec \ud6a8\uc728\uc131\uc5d0 \uae30\ubc18\ud574 \ub2e4\uc591\ud55c \uc9c8\ud658\ub4e4\uc744 \uce58\ub8cc \ud0c0\uae43\uc73c\ub85c \ud558\ub294 \uc784\uc0c1\uc2dc\ud5d8\uc774 \uc9c4\ud589\ub418\uace0 \uc788\ub2e4.<\/p>\n

\uc5ec\uae30\uc5d0 \ucd5c\uadfc \uc720\uc804\uccb4 \ud3b8\uc9d1\uae30\uc220 (genome<\/span>\u00a0editing<\/span>)\ub3c4 \uc720\uc804\uc790\uce58\ub8cc\uc5d0 \uc77c\ubd80\ub85c \ub3c4\uc785\ub418\uba74\uc11c \uc720\uc804\uccb4 \uad50\uc815\uc744 \ud1b5\ud55c \uc9c8\ubcd1 \uce58\ub8cc\ub3c4 \uac00\ub2a5\ud574\uc9c4 \uc0c1\ud669\uc774\ub2e4. 2017\ub144\u00a0ASGCT<\/span>\u00a0\uc804\uccb4 \ubc1c\ud45c\ucd08\ub85d \uc911 \uc138\ubc88\uc9f8\ub85c \ub9ce\uc740 \uae30\uc220\uc774 \ud06c\ub9ac\uc2a4\ud37c \uc720\uc804\uc790\uac00\uc704(13.5%, 106\uac74)\uc600\ub2e4.<\/p>\n

‘\uc720\uc804\uc790\uce58\ub8cc\uc758 \ud604\uc8fc\uc18c’ \ubcf4\uace0\uc11c\uc5d0 \ub530\ub974\uba74, \ud604 \uc2dc\uc810\uc5d0\uc11c \ub9ce\uc740 \uc804\ubb38\uac00\ub4e4\uc774 \ub808\ud2b8\ub85c\ubc14\uc774\ub7ec\uc2a4 \ubca1\ud130,\u00a0AAV<\/span>\u00a0\ubca1\ud130\uc5d0 \uae30\ubc18\ud55c \uc720\uc804\uc790 \uc804\ub2ec\uae30\uc220\uc744 \ud604\uc7ac \uc720\uc804\uc790\uce58\ub8cc \uae30\uc220\uc758 \uc131\uacf5\uc694\uc778\uc73c\ub85c \uaf3d\uace0 \uc788\uc73c\uba70, \uc720\uc804\uccb4 \ud3b8\uc9d1\uae30\uc220\uacfc\uc758 \uc735\ud569\uc744 \ubbf8\ub798 \uc720\uc804\uc790\uce58\ub8cc \uae30\uc220\uc5d0 \ub300\ud55c \uae30\ub300\uc694\uc778\uc73c\ub85c \ud3c9\uac00\ud558\uace0 \uc788\ub2e4.<\/p>\n

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(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n

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 <\/p>\n","protected":false},"excerpt":{"rendered":"

    \uc720\uc804\uc790\uc804\ub2ec \ud6a8\uc728\uc131 \uae30\ubc18 \ub2e4\uc591\ud55c \uc9c8\ud658 \ud0c0\uae43 \uc2dc\ud5d8 \ub80c\ud2f0\ubc14\uc774\ub7ec\uc2a4 \uc6a9\uc774\ud558\uac8c\u00a0SIN\u00a0\ub514\uc790\uc778 \ub3c4\uc785 \uac00\ub2a5 \uc138\uacc4 \uc758\uc57d\ud488 \uc2dc\uc7a5 2025\ub144\uae4c\uc9c0 \ub9e4\ub144 20\uac1c \uc2b9\uc778 \uc720\uc804\uc790\uce58\ub8cc\uc81c \uc5f0\uad6c\uac1c\ubc1c \uacb0\uc2e4 \ub9fa\ub294 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