{"id":4201,"date":"2019-10-07T20:11:51","date_gmt":"2019-10-07T11:11:51","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=4201"},"modified":"2019-10-16T11:30:30","modified_gmt":"2019-10-16T02:30:30","slug":"biologists-who-decoded-how-cells-sense-oxygen-win-2019-medicine-nobel","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4201","title":{"rendered":"Biologists who decoded how cells sense oxygen win 2019 medicine Nobel & 2019 \ub178\ubca8 \uc0dd\ub9ac\uc758\ud559\uc0c1 \uc218\uc0c1\uc790"},"content":{"rendered":"

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William Kaelin, Peter Ratcliffe and Gregg Semenza share award for uncovering how genes react when oxygen is low.<\/h5>\n

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William Kaelin, Peter Ratcliffe and Gregg Semenza have together worked out how genes respond when oxygen is depleted.<\/span>Credit: Ill. Niklas Elmedhed\/Nobel Media<\/p>\n<\/figcaption><\/figure>\n

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A trio of researchers has won the Nobel Prize in Physiology or Medicine for describing how cells sense and respond to oxygen by switching genes on and off \u2014 a discovery that has been key in understanding human diseases such as cancer and anaemia.<\/p>\n

The three scientists are cancer researcher William Kaelin of the Dana-Farber Cancer Institute in Boston, Massachusetts; physician scientist Peter Ratcliffe of Oxford University and the Francis Crick Institute in London, UK; and geneticist Gregg Semenza of Johns Hopkins University School of Medicine in Baltimore, Maryland. The team also won the\u00a0Albert Lasker Basic Medical Research Award in 2016<\/a>.<\/p>\n

The body\u2019s tissues can be deprived of oxygen during exercise, or when blood flow is interrupted, such as during a stroke. Cells\u2019 ability to sense oxygen is also critical to tumour growth, because the mass of rapidly growing cells can deplete oxygen within the interior of a tumour.<\/p>\n