{"id":4061,"date":"2019-09-17T18:13:38","date_gmt":"2019-09-17T09:13:38","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=4061"},"modified":"2019-09-17T18:13:38","modified_gmt":"2019-09-17T09:13:38","slug":"%ec%a7%84%ed%95%b5%ec%83%9d%eb%ac%bc-%ec%a7%84%ed%99%94%ec%9d%98-%ec%97%b4%ec%87%a0-%ec%a5%94-%ea%b3%a0%ec%84%b8%ea%b7%a0-%eb%b0%b0%ec%96%91%ec%97%90-%ec%84%b1%ea%b3%b5%ed%95%98%eb%8b%a4","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4061","title":{"rendered":"\uc9c4\ud575\uc0dd\ubb3c \uc9c4\ud654\uc758 \uc5f4\uc1e0 \uc954 \uace0\uc138\uade0, \ubc30\uc591\uc5d0 \uc131\uacf5\ud558\ub2e4"},"content":{"rendered":"

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\"\"<\/span><\/p>\n

\uc2ec\ud574\uc758 \uc5f4\uc218\ubd84\ucd9c\uacf5 \uc8fc\ubcc0\uc740 \ubbf8\uc0dd\ubb3c\uc774 \uc0b4\uc544\uac08 \uc218 \uc788\ub294 \uc5f4\uacfc \uc601\uc591\ubd84\uc744 \uacf5\uae09\ud55c\ub2e4. \ucd5c\uadfc \uc77c\ubcf8 \uc5f0\uad6c\uc790\ub4e4\uc774 \uc218\uc2ec 2533\ubbf8\ud130 \ud574\uc800\uc5d0\uc11c \ucc44\ucde8\ud55c \ud1a0\uc591 \uc2dc\ub8cc\uc5d0 \uc874\uc7ac\ud558\ub294 \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0\uc744 \uc2e4\ud5d8\uc2e4\uc5d0\uc11c \ubc30\uc591\ud558\ub294 \ub370 \uc131\uacf5\ud574 \ud654\uc81c\uac00 \ub418\uace0 \uc788\ub2e4. ‘\ub124\uc774\ucc98’ \uc81c\uacf5<\/em><\/span><\/p>\n

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\uc5bc\ub9c8 \uc804 \uad6d\uc81c\ud559\uc220\uc9c0 \u2018\ub124\uc774\ucc98’\ub97c \ub4a4\uc801\uc774\ub358 \ud544\uc790\ub294 \uc774\ub2ec 15\uc77c\uc790 \uae30\uc0ac\ub97c \ubcf4\uace0 \ub208\uc774 \ubc88\ub729 \ub728\uc600\ub2e4. \uc77c\ubcf8 \uacfc\ud559\uc790\ub4e4\uc774 \ubb34\ub824 12\ub144\uc5d0 \uac78\uce5c \uac01\uace0\uc758 \ub178\ub825 \ub05d\uc5d0 \uc544\uc2a4\uac00\ub4dc(Asgard<\/span>) \uace0\uc138\uade0\uc744 \uc2e4\ud5d8\uc2e4\uc5d0\uc11c \ubc30\uc591\ud558\ub294 \ub370 \uc131\uacf5\ud588\ub2e4\ub294 \ub0b4\uc6a9\uc774\ub2e4.<\/p>\n

\ubbf8\uc0dd\ubb3c \ud55c \uc885\uc744 \ubc30\uc591\ud55c \uac8c \ubb50 \uadf8\ub9ac \ub300\ub2e8\ud55c \uc131\uacfc\ub0d0\uace0 \uc758\uc544\ud574\ud560 \ub3c5\uc790\ub3c4 \uc788\uaca0\uc9c0\ub9cc \uc774\uac8c \ubcf4\ud1b5 \ubbf8\uc0dd\ubb3c\uc774 \uc544\ub2c8\ub2e4. \uc5b4\uca4c\uba74 \uc0dd\uba85\uacfc\ud559\uc758 \ubbf8\uc2a4\ud130\ub9ac\uc778 \uc9c4\ud575\uc0dd\ubb3c\uc758 \uae30\uc6d0\uc744 \uc124\uba85\ud560 \uc218 \uc788\ub294 \uc5f4\uc1e0\ub97c \uc950\uace0 \uc788\uc744\uc9c0\ub3c4 \ubaa8\ub974\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n

\uc0ac\uc2e4 \ub17c\ubb38\uc740 \uc544\uc9c1 \ud559\uc220\uc9c0\uc5d0 \uc2e4\ub9ac\uc9c0\ub3c4 \uc54a\uc558\ub2e4. \uc9c0\ub09c 8\uc6d4 6\uc77c \ud559\uc220\uc9c0\uc5d0 \ud22c\uace0\ud558\uba70(\uc5b4\ub518\uc9c0\ub294 \uc54c\ub824\uc9c0\uc9c0 \uc54a\uc558\ub2e4) \uc0dd\uba85\uacfc\ud559 \ubd84\uc57c\uc758 \ub17c\ubb38 \uc800\uc7a5\uc18c\uc778 \u2018\ubc14\uc774\uc624 \uc544\uce74\uc774\ube0c(bioRxiv<\/span>)\u2019\uc5d0 \uc62c\ub824 \uacf5\uac1c\ub41c \uac83\uc774\ub2e4. \u2018\ub124\uc774\ucc98\u2019\uac00 \ud22c\uace0 \uc911\uc778 \ub17c\ubb38\uc744 \ub274\uc2a4\ub85c \ub2e4\ub8e8\ub294 \uac74 \ub4dc\ubb38 \uc77c\uc774\ub2e4. \uadf8\ub9cc\ud07c \uc5c4\uccad\ub09c \uc5f0\uad6c\uacb0\uacfc\ub77c\ub294 \ub9d0\uc774\ub2e4.<\/p>\n

\ud544\uc790\ub294 \uadc0\uac00\ud558\uc790\ub9c8\uc790 \uc800\uc790\ub4e4\uc758 \ub17c\ubb38\uc744 \ub2e4\uc6b4\ub85c\ub4dc\ubc1b\uc544 \uc77d\uc5b4\ubd24\ub2e4. \uc2e4\ud5d8 \ub0b4\uc6a9\ub3c4 \ub300\ub2e8\ud588\uc9c0\ub9cc \uadf8 \uacb0\uacfc\uac00 \ud568\ucd95\ud558\ub294 \ubc14\ub3c4 \uc2ec\uc624\ud588\ub2e4. \ud544\uc790\uac00 \ub290\ub080 \uac10\ub3d9\uc744 \ub3c5\uc790\ub4e4\ub3c4 \uacf5\uac10\ud558\uae38 \uae30\ub300\ud558\uba70 \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0 \ubc30\uc591 \uc131\uacf5\uc758 \uc758\ubbf8\uc5d0 \ub300\ud574 \uc124\uba85\ud55c\ub2e4.<\/p>\n

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\ud5c8 \ucc14\ub9b0 \uc2a4\uc6e8\ub374 \uc5f0\uad6c\ud300<\/strong><\/p>\n

\"\"<\/span><\/p>\n

\uc804\uc790\ud604\ubbf8\uacbd\uc73c\ub85c \ubcf8 \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0\u00a0MK-D<\/span>1\uc758 \ubaa8\uc2b5\uc774\ub2e4. \uc138\ud3ec\ub294 \ub300\uc7a5\uade0\ubcf4\ub2e4\ub3c4 \uc791\uc9c0\ub9cc \uc2e4 \uac19\uc740 \ub3cc\ucd9c\ubb3c\uacfc \uc791\uc740 \uc8fc\uba38\ub2c8 \ud615\ud0dc\uc778 \uc18c\ud3ec(\ud654\uc0b4\ud45c)\uac00 \uc874\uc7ac\ud558\ub294 \ud2b9\uc774\ud55c \ud615\ud0dc\ub2e4. \u2018bioRxiv\u2019<\/span>\u00a0\uc81c\uacf5<\/em><\/span><\/p>\n

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\uc624\ub298\ub0a0 \uc0dd\uba85\uacfc\ud559\uc758 \ucd5c\ub300 \ubbf8\uc2a4\ud130\ub9ac\ub294 \uc0dd\ubb3c\uc758 \uae30\uc6d0, \uc5b4\ub5bb\uac8c \ubb34\uc0dd\ubb3c\uc5d0\uc11c \uc0dd\ubb3c\uc774 \ub098\uc654\ub290\ub0d0 \ud558\ub294 \uac83\uc774\ub2e4. \uadf8\ub2e4\uc74c \ubbf8\uc2a4\ud130\ub9ac\uac00 \ubc14\ub85c \uc6d0\ud575\uc0dd\ubb3c\uc5d0\uc11c \uc5b4\ub5bb\uac8c \uc9c4\ud575\uc0dd\ubb3c\uc774 \uc9c4\ud654\ud588\ub290\ub0d0 \uc544\ub2d0\uae4c. \uadf8 \ub4a4 \ub2e8\uc138\ud3ec \uc9c4\ud575\uc0dd\ubb3c\uc5d0\uc11c \ub2e4\uc138\ud3ec \uc9c4\ud575\uc0dd\ubb3c\uc774 \uc9c4\ud654\ud588\uace0 \uad81\uadf9\uc801\uc73c\ub85c \uc0ac\ub78c\uc774 \ub4f1\uc7a5\ud588\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n

\uc9c4\ud575\uc0dd\ubb3c\uc758 \uae30\uc6d0\uc744 \uc124\uba85\ud558\ub294 \uac00\uc124\uc758 \uc804\uac1c\uacfc\uc815\uc744 \ub2e4 \ub418\uc9da\uc5b4\ubcf4\ub824\uba74 \uc774\ubc88 \uc5f0\uad6c\ub97c \ub2e4\ub8e8\uae30\ub3c4 \uc804\uc5d0 \uc9c0\uce60 \uac83\uc774\ubbc0\ub85c \uc0dd\ub7b5\ud558\uace0 \uc624\ub298\ub0a0 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc774 \uc778\uc815\ud558\ub294 \uc2dc\ub098\ub9ac\uc624\ub9cc \uc18c\uac1c\ud55c\ub2e4. \uacfc\uac70 \uc5b4\ub290 \uc2dc\uc810\uc5d0\uc11c(\ub300\ub7b5 20\uc5b5 \ub144 \uc804\uc73c\ub85c \ucd94\uc815) \uc6d0\ud575\uc0dd\ubb3c\uc778 \uace0\uc138\uade0(\uc544\ucf00\uc544)\uc774 \ub610 \ub2e4\ub978 \uc6d0\ud575\uc0dd\ubb3c\uc778 \uc9c4\uc815\uc138\uade0(\ubc15\ud14c\ub9ac\uc544)\ub97c \ud3ec\ud68d\ud588\ub2e4. \ud3ec\ud68d\ub41c \ubc15\ud14c\ub9ac\uc544\ub294 \uc138\ud3ec\uc5d0 \uc5d0\ub108\uc9c0\ub97c \uacf5\uae09\ud558\ub294 \uc138\ud3ec\uc18c\uae30\uad00\uc778 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uac00 \ub410\uace0 \uace0\uc138\uade0\uc758 \uac8c\ub188\uc774 \ub9c9\uc5d0 \ub458\ub7ec\uc2f8\uc774\uba74\uc11c \uc9c4\ud575\uc138\ud3ec\ub85c \uc9c4\ud654\ud588\ub2e4\ub294 \uac83\uc774\ub2e4.<\/p>\n

\uc774 \uc2dc\ub098\ub9ac\uc624\ub294 \uace0\uc138\uade0\uc758 \uac8c\ub188\uc774 \uac19\uc740 \uc6d0\ud575\uc0dd\ubb3c\uc778 \ubc15\ud14c\ub9ac\uc544\uc758 \uac8c\ub188\ubcf4\ub2e4 \uc9c4\ud575\uc0dd\ubb3c\uc758 \uac8c\ub188\uacfc \ub354 \uac00\uae5d\ub2e4\ub294 \ubc1c\uacac\uc5d0 \uae30\ubc18\ud55c\ub2e4. \uadf8\ub7fc\uc5d0\ub3c4 \uadf8 \ucc28\uc774\uac00 \uaf64 \ucee4\uc11c 20\uc5b5 \ub144 \uc804 \ubc15\ud14c\ub9ac\uc544\ub97c \ud3ec\ud68d\ud588\ub358 \uace0\uc138\uade0\uc758 \ubaa8\uc2b5\uc744 \ub5a0\uc62c\ub9ac\uae30\ub294 \uc5b4\ub824\uc6e0\ub2e4.<\/p>\n

\uadf8\ub7f0\ub370 2015\ub144 \u2018\ub124\uc774\ucc98\u2019\uc5d0 \ub180\ub77c\uc6b4 \uc5f0\uad6c\uacb0\uacfc\uac00 \uc2e4\ub838\ub2e4. \uc2a4\uc6e8\ub374 \uc6c1\uc0b4\ub77c\ub300 \ud2f0\uc2a4 \uc5d0\ud0c0\ub9c8 \uad50\uc218\ud300\uc774 \uc218\uc2ec 3283\ubbf8\ud130\uc5d0 \uc774\ub974\ub294 \ubd81\uadf9\ud574\uc758 \ud574\uc800 \ud1a0\uc591\uc744 \ucc44\ucde8\ud574 \uba54\ud0c0\uac8c\ub188\uc744 \ubd84\uc11d\ud55c \uacb0\uacfc \uae30\uc874 \uace0\uc138\uade0\uacfc \uc0c1\ub2f9\ud788 \ub2e4\ub974\uace0 \uc624\ud788\ub824 \uc9c4\ud575\uc0dd\ubb3c\uacfc \ub354 \uac00\uae4c\uc6b4 \uc0c8\ub85c\uc6b4 \uace0\uc138\uade0\uc758 \uc874\uc7ac\ub97c \ud655\uc778\ud588\ub2e4\ub294 \uac83\uc774\ub2e4.<\/p>\n

\uba54\ud0c0\uac8c\ub188(metagenome<\/span>)\uc774\ub780 \uc2dc\ub8cc\uc5d0 \uc788\ub294 \uc0dd\ubb3c\uccb4 \uc804\uccb4\uc758 \uac8c\ub188\uc774\ub2e4. \uc608\uc804\uc5d0\ub294 \uc2e4\ud5d8\uc2e4\uc5d0\uc11c \ubc30\uc591\ud558\ub294 \ub370 \uc131\uacf5\ud55c \ubbf8\uc0dd\ubb3c\ub9cc \uac8c\ub188\uc744 \ubd84\uc11d\ud560 \uc218 \uc788\uc5c8\uc9c0\ub9cc, \uac10\ub3c4\uac00 \ub192\uc740 \ubd84\uc11d\ubc95\uc774 \ub098\uc624\uace0 \uc0dd\ubb3c\uc815\ubcf4\ud559\uc774 \ubc1c\uc804\ud558\uba74\uc11c \uc2dc\ub8cc \uc0c1\ud0dc\uc5d0\uc11c \uac8c\ub188\uc744 \ubc1d\ud790 \uc218 \uc788\ub2e4. \uc5f0\uad6c\uc790\ub4e4\uc740 \uc774 \uace0\uc138\uade0\uc744 \uc704\ud574 \u2018\ub85c\ud0a4\uc544\ucf00\uc624\ud0c0(Lokiarchaeota<\/span>)\u2019\ub77c\ub294 \uc0c8\ub85c\uc6b4 \ubb38(phylum<\/span>)\uc744 \ub9cc\ub4e4\uc5c8\ub2e4.<\/p>\n

\u2018\ub85c\ud0a4\u2019\ub85c \ubd88\ub9ac\ub294 \uc774 \uace0\uc138\uade0\uc758 \uac8c\ub188\uc5d0\ub294 \uc9c0\uae08\uae4c\uc9c0 \uc9c4\ud575\uc0dd\ubb3c\uc5d0\ub9cc \uc788\ub294 \uac83\uc73c\ub85c \uc54c\ub824\uc9c4 \uc720\uc804\uc790\uac00 175\uac1c\ub098 \uc874\uc7ac\ud588\ub2e4. \uc774\uc5b4\uc9c0\ub294 \uba54\ud0c0\uac8c\ub188 \uc5f0\uad6c\uc5d0\uc11c \uc5ec\ub7ec \uc885\uc774 \ucd94\uac00\ub85c \ubc1c\uacac\ub3fc \ub85c\ud0a4 \uc678\uc5d0\ub3c4 \ub124 \uac00\uc9c0 \ubb38\uc774 \ub354 \ub9cc\ub4e4\uc5b4\uc84c\ub2e4. \uac8c\ub188 \ube44\uad50\ubd84\uc11d \uacb0\uacfc \uc774 \uac00\uc6b4\ub370 \ud5e4\uc784\ub2ec\ub77c\ucf00\uc624\ud0c0(Heimdallarchaeota<\/span>)\uac00 \uc9c4\ud575\uc0dd\ubb3c\uacfc \uac00\uc7a5 \uac00\uae4c\uc6b4 \uac83\uc73c\ub85c \ub098\ud0c0\ud0d4\ub2e4. \uc5f0\uad6c\uc790\ub4e4\uc740 2017\ub144 \uc5ed\uc2dc \u2018\ub124\uc774\ucc98\u2019\uc5d0 \ubc1c\ud45c\ud55c \ub17c\ubb38\uc5d0\uc11c \uc774\ub4e4\uc744 \ud3ec\ud568\ud558\ub294 \uc544\uc2a4\uac00\ub4dc \uc0c1\ubb38(Asgard<\/span>\u00a0superphylum<\/span>)\uc744 \uc81c\uc548\ud588\ub2e4.<\/p>\n

\ub530\ub77c\uc11c \uc57d 20\uc5b5 \ub144 \uc804 \uc544\uc2a4\uac00\ub4dc \uc0c1\ubb38\uc5d0 \uc18d\ud558\ub294 \uace0\uc138\uade0(\uc544\ub9c8\ub3c4 \ud5e4\uc784\ub2ec\ub77c\ucf00\uc624\ud0c0)\uc774 \ubc15\ud14c\ub9ac\uc544\ub97c \ud3ec\ud68d\ud574 \uc9c4\ud575\uc0dd\ubb3c\ub85c \ud5a5\ud558\ub294 \uc9c4\ud654\uc758 \uc5ec\uc815\uc744 \uc2dc\uc791\ud588\uc744 \uac00\ub2a5\uc131\uc774 \ub192\ub2e4. \uadf8\ub7fc\uc5d0\ub3c4 \uc2ec\ud574\ucc98\ub7fc \uadf9\ud55c\uc758 \ud658\uacbd\uc5d0\uc11c \uc790\ub77c\ub294 \ubbf8\uc0dd\ubb3c\uc740 \ub300\ubd80\ubd84 \uc2e4\ud5d8\uc2e4\uc5d0\uc11c \ubc30\uc591\uc774 \ub418\uc9c0 \uc54a\uae30 \ub54c\ubb38\uc5d0 \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0\uc774 \uc5b4\ub5bb\uac8c \uc0dd\uacbc\ub294\uc9c0\uc870\ucc28 \uc54c\uc9c0 \ubabb\ud558\ub294 \uc0c1\ud0dc\uc600\ub2e4.<\/p>\n

\uadf8\ub7f0\ub370 \uc774\ubc88\uc5d0 \uc77c\ubcf8\ud574\uc591\uc9c0\uad6c\uacfc\ud559\uae30\uc220\uc5f0\uad6c\uc18c\ub97c \ube44\ub86f\ud55c \uc77c\ubcf8 \uacf5\ub3d9\uc5f0\uad6c\uc790\ub4e4\uc774 \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0\uc744 \ubc30\uc591\ud558\ub294 \ub370 \uc131\uacf5\ud588\ub2e4\uace0 \ubc1c\ud45c\ud55c \uac83\uc774\ub2e4. \ub17c\ubb38\uc5d0\ub294 \ubb3c\ub860 \uace0\uc138\uade0\uc758 \uc804\uc790\ud604\ubbf8\uacbd \uc0ac\uc9c4\ub3c4 \uc2e4\ub824\uc788\ub2e4. \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0 \uc5f0\uad6c\ub97c \uc774\ub04c\uc5c8\uace0 \uc2ed\uc911\ud314\uad6c \ubc30\uc591\uc744 \uc2dc\ub3c4\ud558\uace0 \uc788\uc5c8\uc744 \uc2a4\uc6e8\ub374 \uc6c1\uc0b4\ub77c\ub300 \uc5f0\uad6c\ud300\uc73c\ub85c\uc11c\ub294 \ubd88\uc758\uc758 \uc77c\uaca9\uc77c \uac83\uc774\ub2e4. \uadf8\ub7f0\ub370 \uc5b4\ub5bb\uac8c \uc77c\ubcf8 \uc5f0\uad6c\uc790\ub4e4\uc740 \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0\uc758 \uc874\uc7ac\uac00 \uc54c\ub824\uc9c0\uc9c0\ub3c4 \uc54a\uc740 12\ub144 \uc804\uc5d0 \ubc30\uc591\uc2e4\ud5d8\uc744 \uc2dc\uc791\ud55c \uac83\uc77c\uae4c.<\/p>\n

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\ud06c\uae30\ub294 \uc791\uc9c0\ub9cc \ub3c5\ud2b9\ud55c \uad6c\uc870 \uc9c0\ub140<\/strong><\/p>\n

\uc0ac\uc2e4 \uc774\ub4e4\uc740 \uc2ec\ud574 \ud574\uc800 \ud1a0\uc591\uc744 \ucc44\ucde8\ud574 \uc2e4\ud5d8\uc2e4\uc5d0 \ube44\uc2b7\ud55c \ud658\uacbd\uc758 \ubc30\uc591\uae30\ub97c \ub9cc\ub4e4\uc5b4 \ubc30\uc591\uc744 \uc2dc\ub3c4\ud55c \uac83\uc774\ub2e4. \uc0b0\uc18c\uac00 \uc5c6\ub294 \uc870\uac74\uc5d0\uc11c \uba54\ud0c4\uc744 \uacf5\uae09\ud574 \uc774\ub97c \uba39\uace0 \uc0b4\uc544\uac00\ub294 \ubbf8\uc0dd\ubb3c\uacfc (\ud639\uc2dc \uc788\ub2e4\uba74) \uc774\ub4e4\uacfc \uacf5\uc0dd\ud558\ub294 \ubbf8\uc0dd\ubb3c\uc744 \uc99d\uc2dd\uc2dc\ucf1c \uc2e4\uccb4\ub97c \ubc1d\ud600\ubcfc \uacc4\ud68d\uc774\uc5c8\ub2e4.<\/p>\n

\uc5f0\uad6c\uc790\ub4e4\uc740 2006\ub144 5\uc6d4 6\uc77c \uc77c\ubcf8 \ub0a8\ucabd \ubc14\ub2e4 \ub09c\uce74\uc774 \ud574\uad6c\uc758 \uc218\uc2ec 2533\ubbf8\ud130 \ud574\uc800\uc5d0\uc11c \ucc44\ucde8\ud55c \ud1a0\uc591 \uc2dc\ub8cc\ub97c \ubc30\uc591\uae30\uc5d0 \ub123\uace0 10\u2103\uc5d0\uc11c \ubb34\ub824 2013\uc77c\uc744 \ubc30\uc591\ud588\ub2e4. 5\ub144 \ubc18\uc5d0 \uc774\ub974\ub294 \uae34 \uae30\uac04\uc774\ub2e4. \ud574\uc800 \ubbf8\uc0dd\ubb3c\uc740 \uc99d\uc2dd\uc774 \uc6cc\ub099 \ub354\ub38c \ub450 \ubc30\ub85c \ub298\uc5b4\ub098\ub294 \ub370 \uc218\uac1c\uc6d4\uc774 \uac78\ub9b4 \uc218\ub3c4 \uc788\uae30 \ub54c\ubb38\uc774\ub2e4. \ubc18\uba74 \ub300\uc7a5\uade0 \uac19\uc740 \ubbf8\uc0dd\ubb3c\uc740 \uc870\uac74\ub9cc \ub9de\uc73c\uba74 20\ubd84 \ub9cc\uc5d0 \ub450 \ubc30\uac00 \ub41c\ub2e4.<\/p>\n

\uadf8 \ub4a4 \ubc30\uc591\uc561\uc744 \uc2dc\ud5d8\uad00\uc5d0 \ub098\ub220 \ub2e4\uc2dc \uc5ec\ub7ec \uc870\uac74\uc5d0\uc11c 1\ub144 \ub3d9\uc548 \ubc30\uc591\ud588\ub2e4. \ubc30\uc591\uc561\uc774 \uc57d\uac04 \ubfcc\uc607\uac8c \ub41c(\uc99d\uc2dd\ud588\ub2e4\ub294 \ub73b\uc774\ub2e4) \uc2dc\ud5d8\uad00\uc5d0\uc11c \uc2dc\ub8cc\ub97c \ucc44\ucde8\ud574 \uba54\ud0c0\uac8c\ub188\uc744 \ubd84\uc11d\ud55c \uacb0\uacfc \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0\uc744 \ube44\ub86f\ud574 \ub2e4\uc591\ud55c \ubbf8\uc0dd\ubb3c\uc774 \uc874\uc7ac\ud588\ub2e4. \ub2e4\ub9cc \ucca0\uc800\ud558\uac8c \ubd84\uc11d\ud558\uc9c0 \uc54a\uc558\uae30 \ub54c\ubb38\uc5d0 \ub2f9\uc2dc\ub294 \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0\uac00 \uc5bc\ub9c8\ub098 \uc911\uc694\ud55c \ubbf8\uc0dd\ubb3c\uc778\uc9c0 \ubab0\ub790\ub2e4(\ubb3c\ub860 \uc774\ub984\ub3c4 \ubd99\uc774\uc9c0 \uc54a\uc558\ub2e4).<\/p>\n

\uadf8 \ub4a4 \uc5f0\uad6c\uc790\ub4e4\uc740 \ub2e4\uc591\ud55c \uc870\uac74\uc5d0\uc11c \ubc30\uc591\uc744 \uacc4\uc18d\ud588\uace0 \uc774 \uacfc\uc815\uc5d0\uc11c \uc2a4\uc6e8\ub374 \uc5f0\uad6c\ud300\uc774 \ubc1c\ud45c\ud55c \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0\uc744 \uc790\uc2e0\ub4e4\uc774 \ud0a4\uc6b0\uace0 \uc788\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc54c\uc544\ucc28\ub838\uc744 \uac83\uc774\ub2e4. \uc774 \uac00\uc6b4\ub370 \ud55c \uc885\uc774 \uc99d\uc2dd\uc774 \uc798 \ub3fc \uc2e4\uccb4\ub97c \uaddc\uba85\ud560 \uc218 \uc788\uc5c8\uace0 \uc5f0\uad6c\uc790\ub4e4\uc740 \u2018\ud504\ub85c\uba54\ud14c\uc624\uc544\ucf00\uc6c0 \uc2e0\ud2b8\ub85c\ud53c\ucff0(Prometheoarchaeum<\/span>\u00a0syntrophicum<\/span>)\u2019\uc774\ub77c\ub294 \ud559\uba85\uc744 \ubd99\uc778 \ub4a4 \uade0\uc8fc \u2018MK-D<\/span>1\u2019\uc73c\ub85c \ubd88\ub800\ub2e4. \ub140\uc11d\uc758 \uc628\uc804\ud55c \uac8c\ub188\uc744 \ud574\ub3c5\ud55c \uacb0\uacfc \u2018\ub85c\ud0a4\u2019\uc5d0 \uc18d\ud558\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4.<\/p>\n

\uc804\uc790\ud604\ubbf8\uacbd\uc73c\ub85c \ub4e4\uc5ec\ub2e4\ubcf8\u00a0MK-D<\/span>1\uc758 \ubaa8\uc2b5\uc740 \uc2e4\ub9dd\uc2a4\ub7ec\uc6e0\ub2e4. \uc624\ub298\ub0a0 \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0\uc774 20\uc5b5 \ub144 \uc804 (\ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uac00 \ub420) \ubc15\ud14c\ub9ac\uc544\ub97c \uc2dd\uc791\uc6a9(phagocytosis<\/span>)\uc73c\ub85c \ud3ec\ud68d\ud588\uc744 \uace0\uc138\uade0\uacfc \ube44\uc2b7\ud558\ub2e4\uba74 \ub369\uce58\uac00 \uaf64 \ucee4\uc57c \ud558\ub294 \ub370 1\u339b(\ub9c8\uc774\ud06c\ub85c\ubbf8\ud130. 1\u339b\ub294 100\ub9cc\ubd84\uc758 1\ubbf8\ud130)\ub3c4 \uc548 \ub3fc \ub300\uc7a5\uade0\ubcf4\ub2e4\ub3c4 \uc791\uc558\uae30 \ub54c\ubb38\uc774\ub2e4. \ubc15\ud14c\ub9ac\uc544\ub97c \uc7a1\uc544\uba39\uae30\ub294\ucee4\ub155 \uc7a1\uc544\uba39\ud790 \ud06c\uae30\ub2e4!<\/p>\n

\uadf8\ub7ec\ub098 \uc790\uc138\ud788 \ub4e4\uc5ec\ub2e4\ubcf4\uc790\u00a0MK-D<\/span>1\uc758 \uc0dd\uae40\uc0c8\uac00 \uc608\uc0ac\ub86d\uc9c0 \uc54a\uc558\ub2e4. \uc138\ud3ec \ud45c\uba74\uc5d0 \uc9e7\uc740 \uc904 \uac19\uc740 \ub3cc\ucd9c\ubb3c\uc774 \uc5ec\ub7ff \uc788\uc5c8\ub2e4. \uc5bc\ud54f \uc2e0\uacbd\uc138\ud3ec(\ub274\ub7f0)\ucc98\ub7fc \ubcf4\uc778\ub2e4. \ub610 \ud45c\uba74 \ub9c9\uc5d0 \uc18c\ud3ec(vesicle<\/span>)\uac00 \uc874\uc7ac\ud588\ub2e4. \ub098\uc911\uc5d0 \uc5f0\uad6c\uc790\ub4e4\uc774 \uc81c\uc2dc\ud558\ub294 \uc9c4\ud575\uc0dd\ubb3c \uc9c4\ud654 \uc2dc\ub098\ub9ac\uc624\uc5d0\uc11c \uc774 \ub3cc\ucd9c\ubb3c\uacfc \uc18c\ud3ec\uac00 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4.<\/p>\n

\"\"<\/span><\/p>\n

MK-D<\/span>1\uc758 \ubc30\uc591 \uc870\uac74\uacfc \uac8c\ub188\uc758 \ub300\uc0ac \uad00\ub828 \uc720\uc804\uc790 \ubd84\uc11d\uc744 \ud1a0\ub300\ub85c \uc81c\uc2dc\ud55c \ub300\uc0ac \uba54\ucee4\ub2c8\uc998\uacfc \ubbf8\uc0dd\ubb3c \ub450 \uc885\uacfc\uc758 \uacf5\uc0dd\uc601\uc591 \uad00\uacc4\ub97c \ubcf4\uc5ec\uc8fc\ub294 \ub3c4\uc2dd\uc774\ub2e4. \uc67c\ucabd \ud070 \uc6d0\uc774\u00a0MK-D<\/span>1\uc774\uace0 \uc624\ub978\ucabd \uc704\uac00 \ud669\uc0b0\uc5fc \ud658\uc6d0 \ubc15\ud14c\ub9ac\uc544, \uc624\ub978\ucabd \uc544\ub798\uac00 \uba54\ud0c4 \uc0dd\uc131 \uace0\uc138\uade0\uc774\ub2e4. \u2018bioRxiv\u2019<\/span>\u00a0\uc81c\uacf5<\/em><\/span><\/p>\n

 <\/p>\n

 <\/p>\n

\uacf5\uc0dd \ud30c\ud2b8\ub108\ub294 \ubc15\ud14c\ub9ac\uc544\uc640 \uace0\uc138\uade0<\/strong><\/p>\n

MK-D<\/span>1\uc758 \uac00\uc7a5 \ud765\ubbf8\ub85c\uc6b4 \ud2b9\uc131 \uac00\uc6b4\ub370 \ud558\ub098\ub294 \ud63c\uc790\uc11c\ub294 \uc99d\uc2dd\ud558\uc9c0 \ubabb\ud55c\ub2e4\ub294 \uac83\uc774\ub2e4. \ud30c\ud2b8\ub108 \ubbf8\uc0dd\ubb3c\uc774 \uc874\uc7ac\ud574\uc57c \uc99d\uc2dd\ud560 \uc218 \uc788\ub2e4. \uc774\ub7f0 \uad00\uacc4\ub97c \uc601\uc591\uacf5\uc0dd(syntrophism<\/span>)\uc774\ub77c\uace0 \ubd80\ub978\ub2e4. \uc5f0\uad6c\uc790\ub4e4\uc774 \ud559\uba85\uc744 \uc2e0\ud2b8\ub85c\ud53c\ucff0\uc774\ub77c\uace0 \ubd99\uc778 \uc774\uc720\ub2e4.\u00a0MK-D<\/span>1\uc774 \uc601\uc591\uacf5\uc0dd\uc73c\ub85c \uc0b4\uc544\uac04\ub2e4\ub294 \uac74 \ub9e4\uc6b0 \uc911\uc694\ud55c \ubc1c\uacac\uc774\ub2e4. \uace0\uc138\uade0\uc774 \uacf5\uc0dd\ud558\ub358 \ubc15\ud14c\ub9ac\uc544\ub97c \ud3ec\ud68d\ud588\ub2e4\ub294 \uac8c \uc9c4\ud575\uc0dd\ubb3c \uc9c4\ud654 \uc2dc\ub098\ub9ac\uc624\uc758 \ud575\uc2ec\uc774\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n

\uc5ec\ub7ec \ubc30\uc591\uc870\uac74\uc5d0\uc11c \uc2e4\ud5d8\ud55c \uacb0\uacfc\u00a0MK-D<\/span>1\uc740 \uc544\ubbf8\ub178\uc0b0\uc744 \uba39\uc774\ub85c \uc0bc\uc544 \uc774\ub97c \ubd84\ud574\ud574 \uc5d0\ub108\uc9c0\ub97c \uc5bb\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4.\u00a0MK-D<\/span>1 \uac8c\ub188\uc744 \ud574\ub3c5\ud574 \ub300\uc0ac \uad00\ub828 \uc720\uc804\uc790\ub97c \ubd84\uc11d\ud55c \uacb0\uacfc\ub3c4 \uc774 \uad00\ucc30\uc744 \ub4b7\ubc1b\uce68\ud588\ub2e4. \uc544\ubbf8\ub178\uc0b0 \ubd84\ud574 \uacfc\uc815\uc5d0\uc11c \ub098\uc624\ub294 \uc804\uc790\ub294 \uc218\uc18c\ubd84\uc790\ub098 \ud3ec\ub984\uc0b0\uc5fc \ud615\ud0dc\ub85c \ubc30\ucd9c\ub418\uace0 \uac00\uae4c\uc774 \uc788\ub294 \uacf5\uc0dd \ubbf8\uc0dd\ubb3c\uc774 \uc774\ub97c \uc774\uc6a9\ud574 \uc0b4\uc544\ub098\uac04\ub2e4. \ud55c\ud3b8\u00a0MK-D<\/span>1\uc740 \uacf5\uc0dd \ubbf8\uc0dd\ubb3c\uc774 \ub9cc\ub4e0 \uc544\ubbf8\ub178\uc0b0\uacfc \ube44\ud0c0\ubbfc \ub4f1\uc744 \ud761\uc218\ud574 \uc0b4\uc544\ub098\uac04\ub2e4.<\/p>\n

\uadf8\ub7f0\ub370 \ub9c9\uc0c1 \uacf5\uc0dd\ud558\ub294 \ubbf8\uc0dd\ubb3c\uc758 \uc2e4\uccb4\ub97c \ubcf4\ub2c8 \uc9c4\ud575\uc138\ud3ec \uae30\uc6d0 \uc2dc\ub098\ub9ac\uc624\uc5d0\uc11c \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uac00 \ub41c \uac83\uc73c\ub85c \ucd94\uc815\ud558\ub294 \uc54c\ud30c\ud504\ub85c\ud14c\uc624\ubc15\ud14c\ub9ac\uc6c0(alphaproteobacterium<\/span>)\uc774 \uc544\ub2c8\uc5c8\ub2e4. \ub300\uc2e0 \ud669\uc0b0\uc5fc\uc744 \ud658\uc6d0\uc2dc\ud0a4\ub294 \ubc15\ud14c\ub9ac\uc544\uc640 \uba54\ud0c4\uc744 \uc0dd\uc131\ud558\ub294 \uace0\uc138\uade0\uc774\uc5c8\ub2e4. \ucd94\uac00 \ubc30\uc591\uc2e4\ud5d8 \uacb0\uacfc \ubc15\ud14c\ub9ac\uc544\ub294 \uc5c6\uc5b4\ub3c4 \ub418\uc9c0\ub9cc \uba54\ud0c4 \uc0dd\uc131 \uace0\uc138\uade0\uc740 \uaf2d \uc788\uc5b4\uc57c \ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ubc1d\ud600\uc84c\ub2e4.<\/p>\n

\uace0\uc138\uade0 \ub450 \uc885(MK-D<\/span>1\uacfc \uba54\ud0c4 \uc0dd\uc131 \uace0\uc138\uade0)\uc774 \uc601\uc591\uacf5\uc0dd \uad00\uacc4\uc774\uace0 \ub530\ub77c\uc11c \uc774 \uc790\uccb4\ub85c\ub294 \uc9c4\ud575\uc138\ud3ec \uc9c4\ud654\uc640 \uc9c1\uc811\uc801\uc778 \uad00\ub828\uc774 \uc5c6\ub2e4. \uadf8\ub7fc\uc5d0\ub3c4 \uc5f0\uad6c\uc790\ub4e4\uc740 \ubc30\uc591\uacfc \uac8c\ub188 \ub370\uc774\ud130\ub97c \ubc14\ud0d5\uc73c\ub85c \uc9c4\ud575\uc138\ud3ec \uae30\uc6d0\uc744 \uc124\uba85\ud558\ub294 \uac00\uc124\uc778 \u2018E3 \ubaa8\ud615\u2019\uc744 \ub9cc\ub4e4\uc5c8\ub2e4. E3\uc740\u00a0Entangle<\/span>(\uc5bd\ud798),\u00a0Engulf<\/span>(\uc0bc\ud0b4),\u00a0Enslave<\/span>(\uc608\uc18d)\ub97c \ub73b\ud55c\ub2e4.<\/p>\n

 <\/p>\n

\ubc30\uc591\ub41c \uace0\uc138\uade0 \ubcf4\uace0 \uc0c8\ub85c\uc6b4 \uc2dc\ub098\ub9ac\uc624 \ub9cc\ub4e4\uc5b4<\/strong><\/p>\n

\uc5f0\uad6c\uc790\ub4e4\uc740 \uc9c4\ud575\uc0dd\ubb3c\uc758 \uc9c4\ud654\ub97c \uc5ec\uc12f \ub2e8\uacc4\ub85c \ub098\ub220 \uc81c\uc2dc\ud588\ub2e4. \uccab \ub2e8\uacc4\ub294 \uad11\ud569\uc131\uc744 \ud558\ub294 \uc2dc\uc544\ub178\ubc15\ud14c\ub9ac\uc544\uc758 \ub4f1\uc7a5\uc73c\ub85c \uc0b0\uc18c \ub18d\ub3c4\uac00 \ub192\uc544\uc9c0\uae30 \uc2dc\uc791\ud55c 27\uc5b5 \ub144 \uc804(\ucd94\uc815) \uc774\uc804\uc5d0 \uc77c\uc5b4\ub0ac\uc744 \uac83\uc774\ub2e4. \uc624\ub298\ub0a0 \uc2ec\ud574 \ud574\uc800 \ud1a0\uc591\uc758 \uc870\uac74\uacfc \ube44\uc2b7\ud55c, \uc0b0\uc18c\uac00 \ud76c\ubc15\ud558\uace0 \uc544\ubbf8\ub178\uc0b0 \uac19\uc740 \uc720\uae30\ubb3c\uc774 \uc874\uc7ac\ud558\ub294 \uc6d0\uc2dc \uc9c0\uad6c\uc758 \ud658\uacbd\uc5d0\uc11c \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0\uc740 \uba54\ud0c4 \uc0dd\uc131 \uace0\uc138\uade0\uacfc \uc601\uc591\uc744 \uc8fc\uace0\ubc1b\uc73c\uba70 \uadfc\uadfc\uc774 \uc0b4\uc544\uac14\uc744 \uac83\uc774\ub2e4. \uc624\ub298\ub0a0\u00a0MK-D<\/span>1\uc758 \uc0dd\ud0dc\uc5d0\uc11c \ub2f9\uc2dc \ubaa8\uc2b5\uc744 \uc5ff\ubcfc \uc218 \uc788\ub2e4\ub294 \ub9d0\uc774\ub2e4.<\/p>\n

27\uc5b5 \ub144 \uc804\ubd80\ud130 \uad11\ud569\uc131\uc73c\ub85c \uc0b0\uc18c\uc758 \ub18d\ub3c4\uac00 \uc62c\ub77c\uac00\uae30 \uc2dc\uc791\ud558\uba74\uc11c \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0 \uac00\uc6b4\ub370 \uc0b0\uc18c\uac00 \uc874\uc7ac\uc5d0 \uc801\uc751\ud558\ub294 \uc885\ub958\uac00 \uc0dd\uaca8\ub0ac\ub2e4. \ubc14\ub85c \ud5e4\uc784\ub2ec\ub77c\ucf00\uc624\ud0c0(\uc904\uc5ec\uc11c \ud5e4\uc784\ub2ec)\ub2e4. \uc774 \ud658\uacbd\uc5d0\uc11c\ub294 \ud669\uc0b0\uc5fc\uc744 \ube44\ub86f\ud55c \uc720\uae30\ubb3c\uc774 \ud48d\ubd80\ud588\uc73c\ubbc0\ub85c \ud669\uc0b0\uc5fc\ud658\uc6d0\ubc15\ud14c\ub9ac\uc544\uac00 \uc8fc\ub41c \uacf5\uc0dd \ud30c\ud2b8\ub108\uc600\uc744 \uac83\uc774\uace0 \uc544\uc6b8\ub7ec \uc0b0\uc18c\ub97c \uc774\uc6a9\ud574(\uc0b0\ud654\ubc18\uc751) \uc5d0\ub108\uc9c0\ub97c \ub9cc\ub4dc\ub294 \uc54c\ud30c\ud504\ub85c\ud14c\uc624\ubc15\ud14c\ub9ac\uc6c0\uacfc \uacf5\uc0dd\ub3c4 \uc2dc\uc791\ud588\uc744 \uac83\uc774\ub2e4. \ud5e4\uc784\ub2ec \uc5ed\uc2dc \ubc15\ud14c\ub9ac\uc544\ub97c \uc7a1\uc544\uba39\uae30\uc5d0\ub294 \ub108\ubb34 \uc791\uc558\uc744 \uac83\uc774\ubbc0\ub85c \ud45c\uba74\uc5d0 \ub09c \uae34 \ub3cc\uae30\ub85c \uac10\uc2f8 \uac00\uae4c\uc774 \ub480\uc744 \uac83\uc774\ub2e4.<\/p>\n

\uad11\ud569\uc131\uc774 \ubcf8\uaca9\ud654\ub418\uba74\uc11c \uc0b0\uc18c \ub18d\ub3c4\uac00 \uc810\uc810 \ub192\uc544\uc9c0\uc790 \uc54c\ud30c\ud504\ub85c\ud14c\uc624\ubc15\ud14c\ub9ac\uc6c0\uc774 \uc810\uc810 \ub354 \uc911\uc694\ud574\uc84c\ub2e4. \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0 \ud45c\uba74\uc758 \ub3cc\ucd9c\ubb3c\uacfc \uc18c\ud3ec\uac00 \ubc15\ud14c\ub9ac\uc544\uc640 \uc5bd\ud788\uba74\uc11c(Entangle<\/span>) \uc11c\ub85c \ub5c4 \uc218 \uc5c6\ub294 \uc0ac\uc774\uac00 \ub418\uace0 \uacb0\uad6d \uc0bc\ud0a4\uac8c \ub418\ub294 \uac8c(Engulf<\/span>) \uc138 \ubc88\uc9f8 \ub2e8\uacc4\ub2e4.<\/p>\n

\ubc15\ud14c\ub9ac\uc544\ub97c \uc0bc\ud0a8 \uace0\uc138\uade0\uc5d0\uc11c \ud575\ub9c9\uc774 \ud615\uc131\ub418\ub294 \uac8c \ub124 \ubc88\uc9f8 \ub2e8\uacc4\uc774\uace0 \ubc15\ud14c\ub9ac\uc544 \uac8c\ub188 \ub300\ubd80\ubd84\uc774 \uace0\uc138\uade0 \uac8c\ub188\uc73c\ub85c \ub118\uc5b4\uac00\uba74\uc11c \uc0bc\ucf1c\uc9c4 \ubc15\ud14c\ub9ac\uc544\uac00 \ub3c5\ub9bd\uc131\uc744 \uc783\uc5b4\uac00\ub294 \uacfc\uc815\uc774 \ub2e4\uc12f \ubc88\uc9f8 \ub2e8\uacc4\ub2e4. \uc774\uc81c \ubc15\ud14c\ub9ac\uc544\ub294 \uc644\uc804\ud788 \uc608\uc18d\ub3fc(Enslave<\/span>) \uc138\ud3ec\uc18c\uae30\uad00 \ubbf8\ud1a0\ucf58\ub4dc\ub9ac\uc544\uac00 \ub3fc \uc138\ud3ec\uac00 \ud761\uc218\ud55c \uc601\uc591\ubd84\uc744 \uc0b0\ud654\uc2dc\ucf1c \uc5d0\ub108\uc9c0 \ubd84\uc790(ATP<\/span>)\ub97c \ub9cc\ub4dc\ub294 \uc77c\uc744 \uc804\ub2f4\ud558\ub294 \uac8c \ub9c8\uc9c0\ub9c9 \ub2e8\uacc4\ub2e4.<\/p>\n

\uc774\ubc88 \u2018\ub85c\ud0a4\u2019 \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0 \ubc30\uc591 \uc131\uacf5\uc73c\ub85c \uc54c\uac8c \ub41c \uc9c0\uc2dd\uc744 \ubc14\ud0d5\uc73c\ub85c \uc81c\uc2dc\ub41c E3 \ubaa8\ud615\uc774 \uacfc\uc5f0 \ub9de\ub294 \uac83\uc778\uc9c0\ub294 \uc544\uc9c1 \uc54c \uc218 \uc5c6\uc9c0\ub9cc \ud544\uc790 \ub208\uc5d0\ub294 \uaf64 \uadf8\ub7f4\ub4ef\ud558\uac8c \ubcf4\uc778\ub2e4. \ucc28\ud6c4\uc5d0 \u2018\ud5e4\uc784\ub2ec\u2019 \uace0\uc138\uade0\ub3c4 \ubc30\uc591\uc5d0 \uc131\uacf5\ud55c\ub2e4\uba74 E3 \ubaa8\ud615\uc758 \ub450 \ubc88\uc9f8\uc640 \uc138 \ubc88\uc9f8 \ub2e8\uacc4\ub97c \uc2e4\ud5d8\uc73c\ub85c \ud655\uc778\ud574 \ubcfc \uc218\ub3c4 \uc788\uc9c0 \uc54a\uc744\uae4c. \uc9c0\uae08\uae4c\uc9c0 \uc774\ub860 \uc0dd\ubb3c\ud559\uc758 \uc601\uc5ed\uc5d0 \uba38\ubb3c\ub800\ub358 \uc9c4\ud575\uc138\ud3ec \uc9c4\ud654 \uc5f0\uad6c\uac00 \uc2e4\ud5d8 \uc0dd\ubb3c\ud559\uc73c\ub85c \ub118\uc5b4\uac00\uace0 \uc788\ub2e4.<\/p>\n

 <\/p>\n

\"\"<\/span><\/p>\n

\uc5f0\uad6c\uc790\ub4e4\uc740 \uc774\ubc88\u00a0MK-D<\/span>1\uc758 \ubc1c\uacac\uc744 \ud1a0\ub300\ub85c \uc9c4\ud575\uc0dd\ubb3c\uc758 \uae30\uc6d0\uc744 \uc124\uba85\ud558\ub294 E3 \ubaa8\ud615\uc744 \ub9cc\ub4e4\uc5c8\ub2e4. \uc774\ub97c \uc5ec\uc12f \ub2e8\uacc4\ub85c \uc124\uba85\ud558\ub294 \ub3c4\uc2dd\uc73c\ub85c \uc790\uc138\ud55c \uc124\uba85\uc740 \uc704 \ubcf8\ubb38\uc744 \ucc38\uc870\ud558\ub77c. \u2018bioRxiv\u2019<\/span>\u00a0\uc81c\uacf5<\/em><\/span><\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

    \uc2ec\ud574\uc758 \uc5f4\uc218\ubd84\ucd9c\uacf5 \uc8fc\ubcc0\uc740 \ubbf8\uc0dd\ubb3c\uc774 \uc0b4\uc544\uac08 \uc218 \uc788\ub294 \uc5f4\uacfc \uc601\uc591\ubd84\uc744 \uacf5\uae09\ud55c\ub2e4. \ucd5c\uadfc \uc77c\ubcf8 \uc5f0\uad6c\uc790\ub4e4\uc774 \uc218\uc2ec 2533\ubbf8\ud130 \ud574\uc800\uc5d0\uc11c \ucc44\ucde8\ud55c \ud1a0\uc591 \uc2dc\ub8cc\uc5d0 \uc874\uc7ac\ud558\ub294 \uc544\uc2a4\uac00\ub4dc \uace0\uc138\uade0\uc744 \uc2e4\ud5d8\uc2e4\uc5d0\uc11c(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[33,29,30],"tags":[],"class_list":["post-4061","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","category-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":3974,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3974","url_meta":{"origin":4061,"position":0},"title":"\ub3d9\ubb3c\uc790\uad81 \ube4c\ub824 \uc778\uac04\uc7a5\uae30 \ub9cc\ub4e0\ub2e4\u2026\u65e5, \uc778\uac04\u00b7\ub3d9\ubb3c\uc138\ud3ec \uc735\ud569 \ubc30\uc544 \uc2e4\ud5d8","author":"biochemistry","date":"August 1, 2019","format":false,"excerpt":"\u00a0 \u00a0 \ub3c4\ucfc4\ub300, \uc778\uac04\uc138\ud3ec \uc950 \ubc30\uc544 \ub123\uc5b4 \uc950 \uc790\uad81 \uc774\uc2dd \ub4a4 \ubd84\ub9cc\uae4c\uc9c0 \ucd94\uc9c4 \uc778\uac04 \ucdcc\uc7a5\uc138\ud3ec \ubd84\ub9ac\ub4a4 \uc7a5\uae30\uc774\uc2dd `\uc138\ud3ec\ud63c\ud569` \uc724\ub9ac\uc801 \ubb38\uc81c \uc9c0\uc801\ub3c4 \u00a0 \u00a0 \uc778\uac04\uacfc \ub3d9\ubb3c \uc138\ud3ec\ub97c \ud569\ud55c \ubc30\uc544\ub97c \ub9cc\ub4e0 \ub4a4 \uc774\ub97c \ub3d9\ubb3c \uc790\uad81\uc5d0 \uc774\uc2dd\ud574 \ubd84\ub9cc\uae4c\uc9c0 \uc9c4\ud589\ud558\ub294 \uc5f0\uad6c\uac00 \uc77c\ubcf8\uc5d0\uc11c \ucd94\uc9c4\ub41c\ub2e4. \uc778\uac04 \uc7a5\uae30\ub97c \ub3d9\ubb3c \ubab8\uc5d0\uc11c \ubc30\uc591\ud55c \ub4a4 \uad81\uadf9\uc801\uc73c\ub85c \uc778\uac04 \ubab8\uc5d0 \uc774\uc2dd\ud558\ub294 \uae30\uc220\uc774\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1477,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1477","url_meta":{"origin":4061,"position":1},"title":"\ubab8\ud1b5\uae4c\uc9c0 \uc644\uc131\ub41c \ud504\ub791\ucf04\uc288\ud0c0\uc778, \ub1cc \uc774\uc2dd \ub0a8\uc558\ub2e4","author":"biochemistry","date":"August 28, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 Craig,\u00a0Karl\u00a0\uc81c\uacf5 \u00a0 \ub4f1\uc7a5\ud55c \uc9c0 \uc62c\ud574\ub85c \ub9cc 200\ub144\uc744 \ucc44\uc6b4 \uc18c\uc124 '\ud504\ub791\ucf04\uc288\ud0c0\uc778: \ud604\ub300\uc758 \ud504\ub85c\uba54\ud14c\uc6b0\uc2a4'\ub294 \uc5ec\uc804\ud788 \uacfc\ud559\uacc4\uc758 \ud654\ub450\ub2e4. \ud504\ub791\ucf04\uc288\ud0c0\uc778\uc740 \uc0ac\uc2e4 \uc6d0\uc791\uc5d0\uc11c \uad34\ubb3c\uc744 \ub9cc\ub4e4\uc5b4 \ub0b8 \uacfc\ud559\uc790\uc758 \uc774\ub984\uc774\uc5c8\uc9c0\ub9cc \uc218\ub9ce\uc740 \uc601\ud654\ub098 \uc5f0\uadf9 \ub4f1\uc758 \uc791\ud488\uc5d0\uc11c \uc778\uac04\uc774 \ub9cc\ub4e0 \uad34\ubb3c\uc758 \uc774\ub984\uc73c\ub85c \uac01\uc0c9\ub3fc \ub354 \ub110\ub9ac \uc54c\ub824\uc84c\ub2e4. \ucda9\ub3d9\uc801\uc774\uace0 \ub09c\ud3ed\ud560 \ubfd0\uc544\ub2c8\ub77c \uc5f0\ubbfc\ub3c4 \ub290\ub084 \uc904 \uc544\ub294 \ud504\ub791\ucf04\uc288\ud0c0\uc778. \uc2e4\ud5d8\uc2e4\uc5d0\uc11c\u2026","rel":"","context":"In "'06. \uc5d0\ub108\uc9c0\uc640 \uc5d4\ud2b8\ub85c\ud53c'\uc640 '07. \uacfc\ud559\uacfc \ubb38\uba85' \uad00\ub828"","block_context":{"text":"'06. \uc5d0\ub108\uc9c0\uc640 \uc5d4\ud2b8\ub85c\ud53c'\uc640 '07. \uacfc\ud559\uacfc \ubb38\uba85' \uad00\ub828","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=42"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2944,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2944","url_meta":{"origin":4061,"position":2},"title":"\uc2e4\ud5d8\uc2e4\uc5d0\uc11c \ud0a4\uc6b4 \ub1cc\ub85c \ub1cc \uc9c8\ud658 \uc5f0\uad6c","author":"biochemistry","date":"March 25, 2019","format":false,"excerpt":"\u00a0 \u00a0 [\uc694\uc57d]\u00a0\ub3c5\uc77c \uc5f0\uad6c\ud300\uc774 \uc720\uc804\uc131 \ub1cc \uc9c8\ud658\uc778 \uc2e0\uacbd\uc138\ud3ec\uc774\ub3d9\uc7a5\uc560\ub97c \uc5f0\uad6c\ud560 \uc218 \uc788\ub294 \ub1cc \uc624\uac00\ub178\uc774\ub4dc\ub97c \ub9cc\ub4dc\ub294 \ub370 \uc131\uacf5\ud588\ub2e4.\u00a0\ub1cc \uc624\uac00\ub178\uc774\ub4dc\ub294 \uc2e4\uc81c \uc0ac\ub78c\uc758 \ubab8\uc5d0\uc11c \ub5bc\uc5b4\ub0b8 \uc138\ud3ec\ub97c \ubd84\ud654\uc2dc\ucf1c \ub1cc \uc870\uc9c1\ucc98\ub7fc \ub9cc\ub4e0 \uac83\uc73c\ub85c,\u00a0\ub1cc \uc9c8\ubcd1\uc744 \uc5f0\uad6c\ud558\ub294 \ub370 \ud68d\uae30\uc801\uc778 \ub3c4\uc6c0\uc744 \uc904 \uac83\uc73c\ub85c \uae30\ub300\ub97c \ubaa8\uc73c\ub294 \uae30\uc220\uc774\ub2e4.(2019.03) \u00a0 \uc2e0\uacbd\uc138\ud3ec \uc774\ub3d9\uc744 \uad00\ucc30\ud558\ub294 \ub370 \uc4f0\uc778 \ub1cc \uc624\uac00\ub178\uc774\ub4dc\uac00 \ub2f4\uae34 \ud398\ud2b8\ub9ac\uc811\uc2dc. \ucd9c\ucc98 : \u00a9\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxOTAzMjFfMTI2\/MDAxNTUzMTUzMjcwMjcw.DztK07b757qh0VkL_iygkCiwX53GO7v6bbZHxN8tQmIg.x5l6HDCS05rtvc89RmqwPckF_HKpiEOI4H_xcpzsHEgg.JPEG\/%EB%87%8C_%EC%98%A4%EA%B0%80%EB%85%B8%EC%9D%B4%EB%93%9C2.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxOTAzMjFfMTI2\/MDAxNTUzMTUzMjcwMjcw.DztK07b757qh0VkL_iygkCiwX53GO7v6bbZHxN8tQmIg.x5l6HDCS05rtvc89RmqwPckF_HKpiEOI4H_xcpzsHEgg.JPEG\/%EB%87%8C_%EC%98%A4%EA%B0%80%EB%85%B8%EC%9D%B4%EB%93%9C2.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxOTAzMjFfMTI2\/MDAxNTUzMTUzMjcwMjcw.DztK07b757qh0VkL_iygkCiwX53GO7v6bbZHxN8tQmIg.x5l6HDCS05rtvc89RmqwPckF_HKpiEOI4H_xcpzsHEgg.JPEG\/%EB%87%8C_%EC%98%A4%EA%B0%80%EB%85%B8%EC%9D%B4%EB%93%9C2.jpg?resize=525%2C300&ssl=1 1.5x, 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\ub2e4\ub978 \ub3d9\ubb3c\uc758 \ubab8\uc18d\uc5d0\uc11c \ubc30\uc591\ud558\ub294 \uc5f0\uad6c\uac00 \ud604\uc2e4\ud654\ub418\uace0 \uc788\ub2e4. \uc77c\ubcf8 \ub3c4\ucfc4\ub300\ud559\uad50\uc758 \uc904\uae30\uc138\ud3ec\uc5f0\uad6c\uc18c \ub098\uce74\uc6b0\uce58 \ud788\ub85c\ubbf8\uc4f0(\u4e2d\u5167\u5553\u5149) \uad50\uc218\uac00 \uc0dd\uc950\uc640 \uc2dc\uad81\uc950\uc758 \ubc30\uc544\uc5d0\uc11c \uc778\uac04 \uc138\ud3ec\ub97c \ubc30\uc591\ud55c \uc870\uc9c1\uc744 \ub9cc\ub4e4\uace0 \uc788\uae30 \ub54c\ubb38\uc774\ub2e4. \uad6d\uc81c\ud559\uc220\uc9c0 \ub124\uc774\ucc98\ub294 \u20182020\ub144 \uae30\ub300\ud560 \ub9cc\ud55c \uacfc\ud559\uc774\uc288\u2019 \uc911 \ud558\ub098\ub85c \ub098\uce74\uc6b0\uce58 \uad50\uc218\uc758\u2026","rel":"","context":"In "'06. \uc5d0\ub108\uc9c0\uc640 \uc5d4\ud2b8\ub85c\ud53c'\uc640 '07. \uacfc\ud559\uacfc \ubb38\uba85' \uad00\ub828"","block_context":{"text":"'06. \uc5d0\ub108\uc9c0\uc640 \uc5d4\ud2b8\ub85c\ud53c'\uc640 '07. \uacfc\ud559\uacfc \ubb38\uba85' \uad00\ub828","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=42"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3651,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3651","url_meta":{"origin":4061,"position":4},"title":"\uace0\uccb4\uc774\uba74\uc11c \ub3d9\uc2dc\uc5d0 \ucd08\uc720\uccb4\uc778 \ubb3c\uc9c8\uc740 \uc815\ub9d0 \uc874\uc7ac\ud560\uae4c","author":"biochemistry","date":"June 6, 2019","format":false,"excerpt":"\u00a0 \u00a0 \ucd08\uace0\uccb4 \uc2e4\ud5d8\uc758 \ud575\uc2ec \ubd80\ud488\uc778 \u2018\ube44\ud2c0\ub9bc \uc9c4\ub3d9\uc790\u2019.\u00a0\uadf8 \ub4a4\ub85c\u00a0KAIST\u00a0\ubb3c\ub9ac\ud559\uacfc \uae40\uc740\uc131 \uad50\uc218\uc758 \ubaa8\uc2b5\uc774 \ubcf4\uc778\ub2e4. \uacfc\ud559\ub3d9\uc544 \uc81c\uacf5 \u00a0 \u00a0 2000\ub144\ub300 \ub4e4\uc5b4 \uaca9\ub144\uc73c\ub85c \ub178\ubca8 \uacfc\ud559\uc0c1\uc744 \ubc1b\ub2e4\uc2dc\ud53c \ud558\ub2e4 \ubcf4\ub2c8 \uc77c\ubcf8\uc778 \uc218\uc0c1\uc790\uac00 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\uc678\uacc4\uae30\uc6d0\uc124\u2019 \ud0c4\ub825 &&","author":"biochemistry","date":"June 6, 2019","format":false,"excerpt":"\u00a0 \u00a0 \u00a0 \uc0dd\ubb3c\uccb4\uac00 \uc774\uc6a9\ud558\ub294 \ubaa8\ub4e0 \uc0dd\uccb4\ubd84\uc790\ub294 \uc0dd\ubb3c\uccb4\uc5d0 \uc758\ud574 \ud569\uc131\ub41c\ub2e4. - \ub85c\ubca0\ub974 \ud30c\uc2a4\uce7c, \ub9c9\uc2a4\ubb34\uc2a4\ub871\uc0dd\uccb4\ubd84\uc790\uc5f0\uad6c\uc18c \ucd5c\uadfc \ubd88\uad50\ud559\uc790\uc778 \uc77c\ubcf8 \ud558\ub098\uc870\ub178\ub300 \uc0ac\uc0ac\ud0a4 \uc2dc\uc988\uce74 \uad50\uc218\uac00 \uc4f4 \u2018\ubd93\ub2e4\uc640 \uc544\uc778\uc288\ud0c0\uc778\u2019\uc774\ub77c\ub294 \ucc45\uc744 \uc7ac\ubbf8 \uc77d\uac8c \uc77d\uc5c8\ub2e4. \ucfc4\ud1a0\ub300\uc5d0\uc11c \uacf5\uc5c5\ud654\ud559\uc744 \uacf5\ubd80\ud55c \uc0ac\uc0ac\ud0a4 \uad50\uc218\ub294 \uc774\ud6c4 \ucca0\ud559\uacfc \ubd88\uad50\ud559\uc73c\ub85c \uc9c4\ub85c\ub97c \ubc14\uafe8\ub294\ub370, \ucd08\uae30 \ubd88\uad50\uc640 \ud604\ub300 \uacfc\ud559\uc774 \uc6b0\uc8fc(\uc790\uc5f0)\ub97c \ubcf4\ub294 \uad00\uc810\uc5d0\uc11c \uacb9\uce58\ub294 \uba74\uc774 \ub9ce\ub2e4\ub294 \uac78 \uae68\ub2eb\uace0\u2026","rel":"","context":"In "'05. \ubb3c\uc9c8\uc758 \uc9c4\ud654' \uad00\ub828"","block_context":{"text":"'05. \ubb3c\uc9c8\uc758 \uc9c4\ud654' 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