{"id":3988,"date":"2019-08-03T23:25:50","date_gmt":"2019-08-03T14:25:50","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=3988"},"modified":"2019-08-03T23:25:50","modified_gmt":"2019-08-03T14:25:50","slug":"the-long-shadow-of-a-crispr-scandal","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3988","title":{"rendered":"The long shadow of a CRISPR scandal"},"content":{"rendered":"

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He Jiankui’s controversial gene-editing experiment brought intense scrutiny to CRISPR scientists in China, and they’re outraged.<\/h5>\n<\/div>\n

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As He Jiankui strode to the podium at last year’s summit on human genome editing in Hong Kong, China, more than 1 million people watched online.<\/p>\n

PHOTO: ANTHONY WALLACE\/AFP\/GETTY IMAGES<\/q><\/div>\n<\/div>\n

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In the months after He Jiankui’s widely condemned embryo editing went public, Chinese researchers using the genome editor CRISPR reeled with embarrassment, outrage, and fear of unwarranted scrutiny and criticism of their own work. Some see He as a nobody in the country’s CRISPR community who sullied their whole field. \u201cMany Chinese scientists got angry about [He],\u201d says Deng Hongkui, a stem cell researcher at Peking University in Beijing. \u201cMany of us got training in Western countries, and we know the international standards.\u201d<\/p>\n

An acute concern is that the scandal will besmirch China’s many studies of CRISPR medical treatments that involve altering the DNA of adult somatic cells, such as skin, neurons, and muscles. Edits to those cells, unlike the germline cells in He’s embryo experiments, are not passed to future generations. Many people, Deng says, don’t understand the difference between germline and somatic cell work. \u201cThey just hear \u2018genome editing,\u2019\u201d Deng says. He used CRISPR to make blood-forming stem cells resistant to HIV, and then gave them to an HIV-infected patient who also had leukemia and needed the transplant to battle that disease.<\/p>\n

Wang Haoyi, a developmental biologist at the Institute of Zoology in Beijing, a branch of the Chinese Academy of Sciences (CAS), resents the image He reinforced of Chinese research as the Wild West. \u201cAll the news is that Chinese scientists did this, not that it’s a single person\u2014it’s like they’re crazy people,\u201d says Wang, who did pioneering CRISPR mouse studies in a U.S. lab.<\/p>\n

Yang Hui, who collaborated with Wang on those mouse studies and now is at CAS’s Institute of Neuroscience in Shanghai, says the day after the news broke about the gene-edited babies, he took the unusual step of publicly posting a paper under review at\u00a0Science<\/em>. It showed that a CRISPR variant called a base editor had substantial, unexpected off-target effects. \u201cWe want foreign people to know Chinese scientists also do some good stuff,\u201d Yang says. \u201cWe want to make safer gene-editing tools for patients.\u201d<\/p>\n

The He \u201cincident\u201d has forced Chinese researchers to think twice about future projects. \u201cPeople aren’t daring to do some CRISPR stuff because they don’t want to be criticized,\u201d says Chen Jia, who studies DNA repair at Shanghai Tech University. Chen, who contributed a CRISPR tool used in a study with human embryos never intended for implantation\u2014one of nine such published studies done in China to date\u2014says he would be hesitant to join a similar project today. Even though Chen only provided the gene-editing tool, the He fallout \u201cchanges things.\u201d<\/p>\n

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(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n

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  He Jiankui’s controversial gene-editing experiment brought intense scrutiny to CRISPR scientists in China, and they’re outraged.   As He Jiankui strode to the podium(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[32,33,29],"tags":[],"class_list":["post-3988","post","type-post","status-publish","format-standard","hentry","category-essays-on-science","category-do-biology","category-lets-do-science"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":3992,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3992","url_meta":{"origin":3988,"position":0},"title":"China’s CRISPR revolution","author":"biochemistry","date":"August 3, 2019","format":false,"excerpt":"\u00a0 \u00a0 Editing of plant, animal, and human genomes has never been easier, as this country's scientists are rapidly demonstrating. \u00a0 FOR MANY PEOPLE, CRISPR plus China equals the biophysicist He Jiankui, who infamously used the genome editor last year to alter the DNA of two human embryos that would\u2026","rel":"","context":"In "Essays on Science"","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2836,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2836","url_meta":{"origin":3988,"position":1},"title":"Moratorium for germline editing splits biologists","author":"biochemistry","date":"March 15, 2019","format":false,"excerpt":"\u00a0 \u00a0 A prominent group of 18 scientists and bioethicists from seven countries has called for a global \u201cmoratorium\u201d on human germline editing, the creation of heritable changes in sperm, eggs, or embryos. 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A \u2018search-and-replace\u2019 method for genome editing takes us a giant leap closer to this ambitious goal. \u00a0 \u00a0 Variation in the DNA sequences that constitute the blueprint of\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3986,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3986","url_meta":{"origin":3988,"position":5},"title":"The CRISPR animal kingdom","author":"biochemistry","date":"August 3, 2019","format":false,"excerpt":"\u00a0 \u00a0 China has used the genome editor more aggressively, on more species, than any other country. \u00a0 After using CRISPR to edit a gene that disrupts circadian rhythms in a monkey, Chinese researchers then produced five clones. 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