{"id":3913,"date":"2019-07-18T14:11:09","date_gmt":"2019-07-18T05:11:09","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=3913"},"modified":"2019-10-26T16:04:43","modified_gmt":"2019-10-26T07:04:43","slug":"dna-%ed%8e%b8%ec%a7%91-%ec%9c%a0%ec%a0%84%ec%9e%90-%ea%b0%80%ec%9c%84%ec%9d%98-%ec%a7%84%ed%99%94-%eb%8d%94-%ec%a0%95%ea%b5%90%ed%95%98%ea%b3%a0-%ec%95%88%ec%a0%84%ed%95%98","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3913","title":{"rendered":"DNA \ud3b8\uc9d1 \u2018\uc720\uc804\uc790 \uac00\uc704\u2019\uc758 \uc9c4\ud654 “\ub354 \uc815\uad50\ud558\uace0 \uc548\uc804\ud558\uac8c\u201d & DNA \uc0bd\uc785 \ud6a8\uc728 \ud55c\uce35 \ub192\uc544\uc9c4 \uc720\uc804\uc790 \uad50\uc815\uae30\uc220"},"content":{"rendered":"

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#\uc2e0\uacbd \ud1f4\ud589\uacfc \uc6b4\ub3d9 \ub2a5\ub825 \uc2e4\uc870 \uc99d\uc0c1\uc744 \ubd88\ub7ec\uc624\ub294 \ub8e8\uac8c\ub9ad\ubcd1 \ud658\uc790 A(60)\uc528\ub294 \ucd5c\uadfc \uac1c\uc778 \uc720\uc804\uc790 \uac80\uc0ac\uc5d0\uc11c \u2018TDP-<\/span>43\u2019\uc758 \ubc1c\ud604\uc774 \uc77c\ubc18 \uc0ac\ub78c\ub4e4\ubcf4\ub2e4 \ub9ce\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ub4e4\uc5c8\ub2e4. \uc720\uc804\uc790 \uac00\uc704\ub97c \uc0ac\uc6a9\ud574 A\uc528\uc758 \uc720\uc804\uc790\u00a0TDP-<\/span>43\uc744 \uc815\uc0c1\uc778\uc758 \uac83\uc73c\ub85c \uad50\uccb4\ud560 \uc218 \uc788\ub2e4\uba74 A\uc528\ub294 \ub8e8\uac8c\ub9ad\ubcd1\uc5d0\uc11c \ubc97\uc5b4\ub0a0 \uc218 \uc788\uc744\uae4c?<\/p>\n

\uc138\uc0c1\uc744 \ubc14\uafc0 10\ub300 \uae30\uc220 \uc911 \ud558\ub098\ub85c \uc54c\ub824\uc9c4 \uc720\uc804\uc790 \uac00\uc704 \uae30\uc220\uc774 \uc9c4\ud654\ub97c \uac70\ub4ed\ud558\uace0 \uc788\ub2e4. \ub354 \uc815\ubc00\ud558\uac8c \ud6a8\uc18c\ub97c \uc0ac\uc6a9\ud574 \ub3cc\uc5f0\ubcc0\uc774\u00a0DNA<\/span>\ub97c \uc81c\uac70\ud558\uace0 \ub2e4\ub978\u00a0DNA<\/span>\ub97c \uc0bd\uc785\ud558\ub3c4\ub85d \uae30\uc220\uc801 \ubcc0\uc2e0\uc744 \uc2dc\ub3c4\ud558\ub294 \uc911\uc774\ub2e4.<\/p>\n

\uc774 \uc720\uc804\uc790 \ud3b8\uc9d1 \uae30\uc220\uc744 \uc0ac\uc6a9\ud558\uba74 \uc778\uac04 \ubab8\uc5d0 \ud544\uc694\ud55c \uc601\uc591\uc18c\ub97c \uacf5\uae09\ud574 \uc8fc\ub294 \ub2e8\ubc31\uc9c8\ubd80\ud130 \ubcd1\u00b7\ucda9\ud574\ub97c \uc785\uc9c0\uc54a\ub294 \ub18d\uc791\ubb3c \ud488\uc885\uc758 \uac1c\ubc1c\uc774 \uac00\ub2a5\ud55c \uc0c1\ud0dc\ub2e4. \ud2b9\ud788 \ud604\ub300 \uc758\ud559\uc73c\ub85c \uce58\ub8cc\uac00 \uc5b4\ub824\uc6b4 \uc778\uac04\uc758 \uc720\uc804 \uc9c8\ud658\uc744 \uadfc\ubcf8\uc801\uc73c\ub85c \uace0\uce60 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4.<\/p>\n

\ud604\uc7ac \uc0dd\uba85\uacf5\ud559 \uc5f0\uad6c\uacfc\uc815\uc5d0\uc11c \uac00\uc7a5 \ub9ce\uc774 \uc0ac\uc6a9\ud558\ub294 \uc720\uc804\uc790 \uac00\uc704 \uae30\uc220\uc740 3\uc138\ub300 \u2018\ud06c\ub9ac\uc2a4\ud37c \uce74\uc2a49(CRISPR-CAS<\/span>9)\u2019\uc774\ub2e4. \uac00\uc774\ub4dc\u00a0RNA<\/span>\ub97c \uc774\uc6a9\ud574 \ubcc0\uc774\uac00 \uc788\ub294\u00a0DNA<\/span>\u00a0\uc5fc\uae30\uc11c\uc5f4\uc744 \ucc3e\uc544\ub0b4\uace0 \uce74\uc2a49\uc774\ub77c\ub294 \ud6a8\uc18c\ub85c \uc720\uc804\uc790\ub97c \ud3b8\uc9d1\ud55c\ub2e4.<\/p>\n

\uc774 3\uc138\ub300 \uae30\uc220\uc740 1, 2\uc138\ub300 \uc720\uc804\uc790\uac00\uc704\ubcf4\ub2e4 \uc0c1\ub300\uc801\uc73c\ub85c \uc27d\uace0 \ube44\uc6a9\uc774 \uc801\uac8c \ub4e0\ub2e4\ub294 \uc7a5\uc810\uc774 \uc788\ub2e4. \ubc18\uba74, 1\uc138\ub300 \u2018\uc9d5\ud06c \ud551\uac70 \ub274\ud074\ub808\uc544\uc81c(Zinc<\/span>\u00a0Finger<\/span>\u00a0Nuclease<\/span>)\u2019\uc640 2\uc138\ub300 \u2018\ud0c8\ub80c(TALEN,<\/span>\u00a0Transcriptor<\/span>\u00a0Activator-Like<\/span>\u00a0Effector<\/span>\u00a0Nucleases<\/span>)\u2019\uc758 \uacbd\uc6b0 \uc5fc\uae30\uc11c\uc5f4\uc744 \uc138\uc6b0\uace0 \u2018Fokl\u2019<\/span>\u00a0\ud6a8\uc18c\ub97c \uacb0\ud569\ud558\ub294 \ub4f1 \ub9cc\ub4e4\uae30 \uc5b4\ub824\uc6e0\ub2e4.<\/p>\n

DNA<\/span>\u00a0\uc5fc\uae30\uc11c\uc5f4\uc774 \uc5ed\ubc29\ud5a5\uc73c\ub85c \ubc18\ubcf5\ub41c \ud615\ud0dc\uc778 \ud06c\ub9ac\uc2a4\ud37c\ub294 \uadf8 \uc790\uccb4\ub85c \uce74\uc2a49 \ud6a8\uc18c\ub97c \ud1b5\ud574 \uc720\uc804\uc790 \uc808\ub2e8 \uae30\ub2a5\uc744 \uac16\ub294 \uac83\uc774 \ud2b9\uc9d5\uc774\ub2e4. 1,2\uc138\ub300\ucc98\ub7fc \ubcc4\ub3c4\ub85c \ud6a8\uc18c\ub97c \uacb0\ud569\ud560 \ud544\uc694\uac00 \uc5c6\ub2e4\ub294 \ub73b\uc774\ub2e4. \uadf8\ub7ec\ub098 \ud06c\ub9ac\uc2a4\ud37c \uce74\uc2a49\uc740 \uc758\ub3c4\ud55c \ubd80\ubd84\uc774 \uc544\ub2cc \uc5c9\ub6b1\ud55c \ubd80\ubd84\uc744 \uc27d\uac8c \uc798\ub77c\ub0bc \uc218 \uc788\ub2e4\ub294 \ub2e8\uc810\uc744 \uac16\ub294\ub2e4. \ud55c \ubc88 \uc798\ub824\ub098\uac04\u00a0DNA<\/span>\ub294 \ub2e4\uc2dc \ubcf5\uad6c\ud560 \uc218 \uc5c6\ub2e4.<\/p>\n

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\uc804\uc138\uacc4 \uc0dd\uba85\uacf5\ud559 \uc5f0\uad6c\uc790\ub4e4\uc740 \uc774\ub7ec\ud55c \uc720\uc804\uc790 \uac00\uc704\uc758 \ub2e8\uc810\uc744 \uadf9\ubcf5\ud558\uace0 \ub300\uccb4\ud558\ub294 \ubc29\ubc95\uc744 \uacc4\uc18d\ud574\uc11c \ucc3e\ub294 \uc911\uc774\ub2e4. \uc77c\ub840\ub85c \ud06c\ub9ac\uc2a4\ud37c \uc720\uc804\uc790\uac00\uc704 \uc5f0\uad6c\uc758 \uc120\uad6c\uc790\ub85c \uc54c\ub824\uc9c4 \uc7a5\ud391(Zhang<\/span>\u00a0Feng<\/span>) \uba54\uc0ac\ucd94\uc138\uce20 \uacf5\uacfc\ub300\ud559 \uad50\uc218\ub294 \uce74\uc2a49\uc744 \ub300\uccb4\ud560 \ud6a8\uc18c\ub85c \u2018Cpfl\u2019<\/span>\u00a0\ub2e8\ubc31\uc9c8\uc744 \uc9c0\ubaa9\ud588\ub2e4.<\/p>\n

\uae40\uc9c4\uc218 \uae30\ucd08\uacfc\ud559\uc5f0\uad6c\uc6d0 \uc720\uc804\uccb4\uad50\uc815\uc5f0\uad6c\ub2e8 \uc218\uc11d\uc704\uc6d0\uc740 \uc9c0\ub09c 2017\ub144 \uc774\u00a0Cpfl<\/span>\u00a0\ud6a8\uc18c\ub97c \uc0ac\uc6a9\ud55c \ud06c\ub9ac\uc2a4\ud37c\uac00\uc704\ub85c \ud2b9\uc815 \uc720\uc804\uc790 \ub0b4\u00a0DNA<\/span>\u00a0\uc5fc\uae30 \ud558\ub098\ub9cc\uc744 \ud3b8\uc9d1\ud558\ub294 \uc2e4\ud5d8\uc5d0 \uc131\uacf5\ud588\ub2e4. \uce74\uc2a49\uc73c\ub85c\ub294 \uad50\uc815\ud560 \uc218 \uc5c6\ub294 \uc815\uad50\ud55c \ud3b8\uc9d1\uc774 \ub3d9\ubb3c\uc2e4\ud5d8 \uc218\uc900\uc5d0\uc11c \uac00\ub2a5\ud574\uc9c4 \uac83\uc774\ub2e4.<\/p>\n

\ub2f9\uc2dc \uc5f0\uad6c\ud300\uc740 \uc0dd\uc950\uc758 \uba5c\ub77c\ub2cc \uc0dd\uc131\uc5d0 \uad00\uc5ec\ud558\ub294 \ud2f0\ub85c\uc2dc\ub098\uc81c(Tyr<\/span>) \uc720\uc804\uc790\ub97c \ud06c\ub9ac\uc2a4\ud37c-Cpfl<\/span>\uc744 \uc774\uc6a9\ud574 \uc5fc\uae30 \ub0b4 \ud2b9\uc815 \uc704\uce58\ub9cc\uc744 \ubc14\uafe8\ub2e4. \uadf8 \uacb0\uacfc \uc720\uc804\uc790 \uad50\uc815 \uc0dd\uc950\ub294 \uac01\uac01 \uadfc\ubb34\ub825\uc99d\uacfc \ubc31\uc0c9\uc99d\uc744 \uac16\uac8c \ub410\ub2e4.<\/p>\n

\uc815\ud655\ub3c4\ub97c \ub192\uc774\ub294 \ubc29\ubc95\uacfc \ub2ec\ub9ac \uc624\uc791\ub3d9\uc744 \ub9c9\ub294 \uc5f0\uad6c\ub3c4 \uc788\ub2e4. \ud06c\ub9ac\uc2a4\ud1a0\ud37c \uc720\uc804\uc790 \uac00\uc704\uc758 \ud6a8\uc18c\uc5d0 \ubc1c\ud604\uc744 \uacb0\uc815\ud558\ub294 \uc2a4\uc704\uce58 \uc5ed\ud560\uc744 \ub2ec\uc544 \ud544\uc694\ud560 \ub54c\ub9cc\u00a0DNA<\/span>\u00a0\uc808\ub2e8\uc744 \ud558\ub294 \ubc29\uc2dd\uc774\ub2e4. \uae30\uc874 \uc720\uc804\uc790\uac00\uc704\uc5d0 \uc548\uc804\uc7a5\uce58\ub97c \ucd94\uac00\ud55c \uc148\uc774\ub2e4.<\/p>\n

\uc808\ub2e8\uc774 \uc544\ub2cc \ub2e4\ub978 \uc720\uc804\uc790 \ud3b8\uc9d1 \ub3c4\uad6c\ub97c \uac1c\ubc1c\ud558\ub294 \uc5f0\uad6c\ub3c4 \ud55c\ucc3d\uc774\ub2e4. \ubbf8\uad6d \uceec\ub7fc\ube44\uc544\ub300 \uc5f0\uad6c\ud300\uc740 \ucd5c\uadfc \uc720\uc804\uc790\ub97c \uc808\ub2e8\ud558\uc9c0 \uc54a\ub294 \uc0c8\ub85c\uc6b4 \uc720\uc804\uc790 \ud3b8\uc9d1 \ubc29\uc2dd \u2018\uc778\ud14c\uadf8\ub808\uc774\ud2b8(INTEGRATE<\/span>)\u2019\ub97c \uac1c\ubc1c\ud558\uace0 \uad6d\uc81c\ud559\uc220\uc9c0 \ub124\uc774\ucc98(NATURE<\/span>)\uc5d0 \uacb0\uacfc\ub97c \ubc1c\ud45c\ud588\ub2e4.<\/p>\n

\uc774 \uc778\ud14c\uadf8\ub808\uc774\ud2b8 \ud3b8\uc9d1 \ubc29\uc2dd\uc740 \ucf5c\ub77c\ub77c\uade0\uc5d0\uc11c \u2018\uc810\ud551 \uc720\uc804\uc790(jumping<\/span>\u00a0gene<\/span>)\u2019\ub77c\uace0 \ubd88\ub9ac\ub294 \uc774\ub3d9\uc131 \uc720\uc804\uc790\ub97c \uc774\uc6a9\ud55c \uac83\uc774 \ud575\uc2ec\uc774\ub2e4. \ud06c\ub9ac\uc2a4\ud37c\uac00 \uce74\uc2a49 \ud6a8\uc18c\ub85c\u00a0DNA<\/span>\ub97c \uc808\ub2e8\ud574\u00a0DNA<\/span>\uc0ac\uc2ac\ub85c \ub4e4\uc5b4\uac04\ub2e4\uba74 \uc810\ud551 \uc720\uc804\uc790\ub294 \ud6a8\uc18c\ub97c \uc0ac\uc6a9\ud574 \ub4e4\ub7ec\ubd99\ub294 \ud2b9\uc9d5\uc744 \uac16\uace0 \uc788\ub2e4.<\/p>\n

\uc774\ub7ec\ud55c \uc810\ud551 \uc720\uc804\uc790\ub97c \uc0ac\uc6a9\ud560 \uacbd\uc6b0 \ud06c\ub9ac\uc2a4\ud37c \uc720\uc804\uc790 \uac00\uc704\uac00 \uac16\ub294 \ubcc0\uc774 \ud6c4\u00a0DNA<\/span>\u00a0\uc5fc\uae30\uc758 \ud0c8\ub77d, \ucd94\uac00 \ub4f1 \uc624\ub958\ub97c \ubcf4\uc644\ud560 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4. \ud06c\ub9ac\uc2a4\ud37c \uc720\uc804\uc790 \uac00\uc704\ub85c \uc798\ub77c\uc9c4\u00a0DNA<\/span>\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \u2018NHEJ<\/span>(\uc0c1\ub3d9 \ub9d0\ub2e8 \uc811\ud569)\u2019\uc774\ub77c\ub294 \uc138\ud3ec \ubcf4\uc0c1\uacfc\uc815\uc744 \ud1b5\ud574 \ubcf5\uad6c\ud558\ub294 \uacfc\uc815\uc744 \uac70\uce58\ub294\ub370 \uc774\ub54c\u00a0DNA<\/span>\u00a0\ubcf5\uad6c\uac00 \uc644\ubcbd\ud558\uac8c \uc774\ub904\uc9c0\uc9c0 \uc54a\uc744 \uc218 \uc788\ub2e4.<\/p>\n

\uc810\ud551\uc720\uc804\uc790\ub294 \uc6d0\ud558\ub294 \uc704\uce58\uc5d0 \ub2ec\ub77c\ubd99\uc5b4 \uc0bd\uc785\ub418\ub294 \ubc29\uc2dd\uc774\uae30 \ub54c\ubb38\uc5d0 \uc774\ub7ec\ud55c \ubcf5\uad6c \uacfc\uc815 \uc2dc \ubc1c\uc0dd\ud560 \uc218 \uc788\ub294 \uc624\ub958\uac00 \uc5c6\ub2e4\ub294 \uac83\uc774 \uc774 \uc5f0\uad6c\ud300\uc758 \uc124\uba85\uc774\ub2e4. \ub2e4\ub9cc, \uc544\uc9c1\uae4c\uc9c0 \uc2e4\ud5d8\ub3d9\ubb3c\uc774\ub098 \uc0ac\ub78c \ub300\uc0c1 \uc720\uc804\uc790 \ud3b8\uc9d1\uc774 \uac00\ub2a5\ud55c \uc218\uc900\uc5d0 \ub3c4\ub2ec\ud558\uc9c0\ub294 \ubabb\ud588\ub2e4.<\/p>\n

\uad6d\ub0b4 \uc720\uc804\uccb4 \uad00\ub828 \ud55c \ubc14\uc774\uc624\uae30\uc5c5 \uad00\uacc4\uc790\ub294 “3\uc138\ub300 \ud06c\ub9ac\uc2a4\ud37c \uc720\uc804\uc790 \uac00\uc704\uac00 \uc26c\uc6b4 \uc81c\uc791 \uacfc\uc815\uacfc \uc800\ub834\ud55c \ube44\uc6a9\uc73c\ub85c \uc720\uc804\uccb4 \uad50\uc815 \uc5f0\uad6c\uc758 \uac00\uc18d\ud654\ub97c \ubd88\ub7ec\uc654\ub2e4”\uba74\uc11c “\uc544\uc9c1\uae4c\uc9c0 \uc815\ubcf5\ub418\uc9c0 \ubabb\ud55c \uc778\uac04 \uc720\uc804\uc131 \ub09c\uce58 \uc9c8\ud658\uc744 \uce58\ub8cc\ud560 \uc218 \uc788\ub294 \uc815\ubc00\ud654\ub41c \uc720\uc804\uc790 \uac00\uc704 \uae30\uc220\uc758 \ub4f1\uc7a5\uc744 \uace0\ub300\ud558\uace0 \uc788\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

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(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n

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\"\"<\/span><\/p>\n

\uc0ac\uc774\uc5b8\uc2a4 \uc81c\uacf5<\/em><\/span><\/p>\n

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\uad6d\uc81c\ud559\uc220\uc9c0 \u2018\uc0ac\uc774\uc5b8\uc2a4\u2019\ub294 5\uc77c \ucd08\ub85d\uc0c9 \uacfc\ub141\uc5d0\u00a0DNA<\/span>\ub97c \ub2ee\uc740 \ud654\uc0b4\uc774 \uc815\ud655\ud788 \uc815\uc911\uc559\uc5d0 \uaf42\ud788\ub294 \ubaa8\uc2b5\uc744 \ud45c\uc9c0\ub85c \uc2e4\uc5c8\ub2e4. \ucd5c\ucca8\ub2e8 \uc720\uc804\uc790 \uad50\uc815\uae30\uc220\uc778 \ud06c\ub9ac\uc2a4\ud37c \uc720\uc804\uc790\uac00\uc704(CRISPR-Cas<\/span>)\ub97c \uc774\uc6a9\ud574\u00a0DNA<\/span>\ub97c \uc218\uc815\ud558\ub294 \ubaa8\uc2b5\uc744 \ubb18\uc0ac\ud588\ub2e4. \ud06c\ub9ac\uc2a4\ud37c\ub294 \ubc15\ud14c\ub9ac\uc544\uc640 \uace0\uc138\uade0\uacfc \uac19\uc740 \uc6d0\ud575\uc0dd\ubb3c \uc720\uae30\uccb4\uc758 \uac8c\ub188\uc5d0\uc11c \ubc1c\uacac\ub418\ub294\u00a0DNA<\/span>\u00a0\uc11c\uc5f4\uc774\uba70 \uce74\uc2a4\ub294\u00a0DNA<\/span>\u00a0\uc778\uc2dd\ud558\uace0 \uc808\ub2e8\ud558\uae30 \uc704\ud55c \uac00\uc774\ub4dc\ub85c \uc0ac\uc6a9\ub418\ub294 \ud6a8\uc18c\uc758 \uc77c\uc885\uc774\ub2e4.<\/p>\n

\ub300\ubd80\ubd84\uc758 \uc6d0\ud575\uc0dd\ubb3c\uc740 \ud658\uacbd\uc5d0 \uc801\uc751\ud558\uba70 \ud615\uc131\ub41c \ud6c4\uc804\uc801\uc778 \uba74\uc5ed \uccb4\uacc4\ub97c \ub73b\ud558\ub294 \uc801\uc751\uba74\uc5ed\uc744 \uad6c\ucd95\ud558\uae30 \uc704\ud574 \ud06c\ub9ac\uc2a4\ud37c-\uce74\uc2a4 \uc2dc\uc2a4\ud15c\uc5d0 \uc758\uc874\ud55c\ub2e4. \ud06c\ub9ac\uc2a4\ud37c\uc5d0\uc11c \uc0dd\uc0b0\ub41c \uc791\uc740\u00a0RNA<\/span>\ub4e4\uc740 \uce74\uc2a4\uac00 \ud45c\uc801\uc744 \ud5a5\ud574 \uce68\uc785\ud558\ub294 \ubc14\uc774\ub7ec\uc2a4\ub098 \uce68\uc785\uc790\ub4e4\uc758 \ud575\uc0b0\uc744 \uc0c9\ucd9c\ud558\uace0 \ud30c\uad34\ud560 \uc218 \uc788\ub3c4\ub85d \uac00\uc774\ub4dc \uc5ed\ud560\uc744 \ud55c\ub2e4. \ud06c\ub9ac\uc2a4\ud37c\uc5d0\ub294 \uc5ec\ub7ec\uac00\uc9c0 \uc885\ub958\uac00 \uc788\ub294\ub370 \uadf8 \uc720\ud615\uc740 \uac01\uac01\uc758 \ub2e8\ubc31\uc9c8 \uad6c\uc131\uc5d0 \ub530\ub77c \uaddc\uc815\ub41c\ub2e4. \ucd5c\uadfc \uce74\uc2a49\uacfc \uce74\uc2a412\ub97c \uac00\uc774\ub4dc \ud558\ub294\u00a0II<\/span>\ud615\uacfc V\ud615 \ud06c\ub9ac\uc2a4\ud37c\uac00\u00a0DNA<\/span>\u00a0\uc11c\uc5f4 \ubcc0\ud615\uc744 \uac00\ub2a5\ucf00 \ud558\uba70 \uc720\uc804\uccb4 \ud3b8\uc9d1\uc5d0 \ud601\uba85\uc744 \uc77c\uc73c\ucf30\ub2e4. \ud558\uc9c0\ub9cc \ud06c\ub9ac\uc2a4\ud37c\ub97c \ud1b5\ud55c \uc720\uc804\uccb4 \ud3b8\uc9d1 \ud6c4 \uc190\uc0c1\ub41c\u00a0DNA<\/span>\u00a0\uc774\uc911\uac00\ub2e5\uc744 \ubcf5\uad6c\ud558\ub294 \uacfc\uc815\uc774 \ud544\uc694\ud574 \ud3b8\uc9d1\uc758 \ud6a8\uc728\uc131\uc774 \ub5a8\uc5b4\uc9c4\ub2e4\ub294 \ub2e8\uc810\uc774 \uc874\uc7ac\ud55c\ub2e4.<\/p>\n

\ud391 \uc7a5 \ubbf8\uad6d \ub9e4\uc0ac\ucd94\uc138\uce20\uacf5\ub300(MIT<\/span>) \uc0dd\uba85\uacf5\ud559\uacfc \uad50\uc218 \uc5f0\uad6c\ud300\uc740 \u2018\ud06c\ub9ac\uc2a4\ud37c-\uc5f0\uad00 \ud2b8\ub79c\uc2a4\ud3ec\uc0ac\uc81c(CAST<\/span>)\u2019\uac00 \uc720\uc804\uccb4 \ud3b8\uc9d1\uc758 \ud6a8\uc728\uc131\uc744 \ub192\uc5ec\uc904 \uc218 \uc788\ub2e4\ub294 \uc5f0\uad6c\uacb0\uacfc\ub97c \ubc1c\ud45c\ud588\ub2e4. \ud06c\ub9ac\uc2a4\ud37c-\uc5f0\uad00 \ud2b8\ub79c\uc2a4\ud3ec\uc0ac\uc81c\ub294 \uc5fd\ub85d\uc18c\ub97c \uac00\uc9c0\uace0 \uad11\ud569\uc131\uc744 \ud558\ub294 \uc138\uade0\uc778 \ub0a8\uc138\uade0\uc5d0\uc11c \ucd94\ucd9c\ud55c \uac83\uc73c\ub85c \u2018\uce74\uc2a412k\u2019<\/span>\uc640 \u2018\ud2b8\ub79c\uc2a4\ud3ec\uc0ac\uc81c \uc11c\ube0c\uc720\ub2c8\ud2b8\u2019\ub85c \uad6c\uc131\ub418\uc5b4\uc788\ub2e4. \uc11c\ube0c\uc720\ub2c8\ud2b8\ub294 \ub2e8\ubc31\uc9c8\uc758 \uac00\uc7a5 \uc801\uc740 \uacf5\uc720\uacb0\ud569 \ub2e8\uc704\ub97c, \ud2b8\ub79c\uc2a4\ud3ec\uc0ac\uc81c\ub294\uc720\uc804\uccb4 \ub0b4 \uc704\uce58\ub97c \uc774\ub3d9\ud560 \uc218 \uc788\ub294 \uc720\uc804\uc790\ub97c \ub73b\ud55c\ub2e4.<\/p>\n

\uc5f0\uad6c\ud300\uc740\u00a0CAST<\/span>\ub97c \uac00\uc9c0\uace0 \ub300\uc7a5\uade0 \uc720\uc804\uccb4\uc5d0 \ub300\ud55c \uc778\ube44\ubcf4 \uc5f0\uad6c\ub97c \uc9c4\ud589\ud55c \uacb0\uacfc,\u00a0CAST<\/span>\uac00 \ub300\uc7a5\uade0\uc758 \uc720\uc804\uccb4\uc5d0 \ub9e4\uc6b0 \ud6a8\uc728\uc801\uc73c\ub85c\u00a0DNA<\/span>\ub97c \uc0bd\uc785\ud558\ub294 \uac83\uc744 \ud655\uc778\ud588\ub2e4. \uc5f0\uad6c\ud300\uc740 \u201cDNA<\/span>\uc774\uc911\uac00\ub2e5\uc744 \ubcf5\uad6c\ud558\ub294 \uacfc\uc815\uc774 \uc5c6\uc774\ub3c4 60~66 \uc5fc\uae30\uc30d\uc758\u00a0DNA<\/span>\u00a0\uc870\uac01\uc744 \ud55c \ubc29\ud5a5\uc73c\ub85c \uc0bd\uc785\ud558\ub294\ub370 \uc131\uacf5\ud588\ub2e4\u201d\uba70 \u201cCAST<\/span>\ub294 80%\uc758 \uc720\uc804\uc790 \ube48\ub3c4\ub85c \ub300\uc7a5\uade0 \uc720\uc804\uccb4\uc758 \ud0c0\ucf13 \uc9c0\uc810\uc5d0\u00a0DNA<\/span>\ub97c \ud761\uc218\uc2dc\ucf30\ub2e4\u201d\uace0 \uc124\uba85\ud588\ub2e4. \uc720\uc804\uc790 \ube48\ub3c4\ub294 \ud558\ub098\uc758 \ud2b9\uc815 \uc9d1\ub2e8 \uc874\uc7ac\ud558\ub294 \uac01\uac01\uc758 \ub300\ub9bd\uc720\uc804\uc790\uac00 \ub098\ud0c0\ub0a0 \uc0c1\ub300\uc801 \ube44\uc728\uc744 \uc758\ubbf8\ud55c\ub2e4.<\/p>\n

\uc7a5 \uad50\uc218\ub294 \u201c\uc774\ubc88 \uc5f0\uad6c\ub294 \ud06c\ub9ac\uc2a4\ud37c \uce74\uc2a4 \uc2dc\uc2a4\ud15c\uc758 \uae30\ub2a5\uc801 \ub2e4\uc591\ud568\uc5d0 \ub300\ud55c \uc6b0\ub9ac\uc758 \uc774\ud574\ub97c \ub113\ud614\uc73c\uba70 \uc815\ud655\ud55c\u00a0DNA<\/span>\u00a0\uc0bd\uc785\uc5d0 \ub300\ud55c \ud558\ub098\uc758 \ud328\ub7ec\ub2e4\uc784\uc744 \uc815\ub9bd\ud55c \uac83\u201d\uc774\ub77c\uba70 \u201c\uc720\uc804\uc790 \uacf5\ud559\uacfc \uc720\uc804\uc790 \uce58\ub8cc \uc5f0\uad6c\ub97c \ubc14\uafc0 \uc218 \uc788\ub294 \uc0c8\ub85c\uc6b4 \ub3c4\uad6c\uac00 \ub420 \uac83\u201d\uc774\ub77c\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

 <\/p>\n

 <\/p>\n

(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

    #\uc2e0\uacbd \ud1f4\ud589\uacfc \uc6b4\ub3d9 \ub2a5\ub825 \uc2e4\uc870 \uc99d\uc0c1\uc744 \ubd88\ub7ec\uc624\ub294 \ub8e8\uac8c\ub9ad\ubcd1 \ud658\uc790 A(60)\uc528\ub294 \ucd5c\uadfc \uac1c\uc778 \uc720\uc804\uc790 \uac80\uc0ac\uc5d0\uc11c \u2018TDP-43\u2019\uc758 \ubc1c\ud604\uc774 \uc77c\ubc18 \uc0ac\ub78c\ub4e4\ubcf4\ub2e4 \ub9ce\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ub4e4\uc5c8\ub2e4. \uc720\uc804\uc790 \uac00\uc704\ub97c(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[41,42,43,38,33,34,29,30],"tags":[],"class_list":["post-3913","post","type-post","status-publish","format-standard","hentry","category-05---","category-06---07---","category-08----09---","category-38","category-do-biology","category-lets-do-chemistry","category-lets-do-science","category-recent-science-news"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t