{"id":3895,"date":"2019-07-16T13:05:43","date_gmt":"2019-07-16T04:05:43","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=3895"},"modified":"2019-07-16T13:05:43","modified_gmt":"2019-07-16T04:05:43","slug":"crispr-patent-fight-revived","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3895","title":{"rendered":"CRISPR patent fight revived"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p id=\"p-3\">A surprise ruling last week reignited the high-profile patent fight over who invented a key application of the genome editor CRISPR. The 3-year-old battle pits parties represented by the University of California (UC) against the Broad Institute in Cambridge, Massachusetts. It revolves around the use of CRISPR, originally derived from a DNA-cutting system used by bacteria, in the more complex cells of eukaryotes\u2014including humans, which means the outcome could shape the development of potentially lucrative CRISPR-based medical treatments.<\/p>\n<p id=\"p-4\">Triggered by new patent claims from the UC group, the development resurrects contentious debates that calmed down after a court decision in September 2018 favoring the Broad Institute. The UC team, which represents Jennifer Doudna from UC Berkeley and her collaborators, had first published the use of CRISPR as a genome-editing tool in\u00a0<em>Science<\/em>\u00a0in June 2012, but they did not demonstrate that it worked in eukaryotes.<\/p>\n<p id=\"p-5\">In January 2013, Broad&#8217;s team, led by Feng Zhang, published a paper\u2014also in\u00a0<em>Science<\/em>\u2014that described its success in mouse and human cells. After the U.S. Patent and Trademark Office awarded Broad several patents, UC requested what&#8217;s known as an interference, contesting Broad&#8217;s patents based on its own submitted patent. UC&#8217;s attorneys argued that after the Doudna group&#8217;s 2012 paper, it was \u201cobvious\u201d that CRISPR would work in eukaryotes.<\/p>\n<p id=\"p-6\">The Patent Trial and Appeal Board (PTAB) ruled against UC in February 2017, and the U.S. Court of Appeals for the Federal Circuit denied UC&#8217;s appeal 1 year later. In April 2018, however, UC filed new patent claims that highlighted its invention&#8217;s utility in eukaryotic cells, prompting PTAB to rule that the two parties&#8217; claims now create an interference issue that needs to be examined in a hearing.<\/p>\n<p id=\"p-7\">Eldora Ellison, a lead attorney for the UC team\u2014who works at Sterne, Kessler, Goldstein &amp; Fox in Washington, D.C., says PTAB ruled in 2017 that there was no interference because Broad focused on eukaryotes and the UC patent made claims about the utility of CRISPR in \u201cany environment.\u201d \u201cWhat they said is, \u2018We&#8217;re actually not going to have a fight at this point in time, because we think that these are two different inventions,\u2019\u201d Ellison says. \u201cThey kind of kicked the can down the road on who was first to invent the use of CRISPR in eukaryotes.\u201d<\/p>\n<p id=\"p-8\">Now that UC has sharpened its claim to the use of CRISPR in eukaryotes, Broad \u201c[looks] forward to participating in the interference process,\u201d according to a statement from the institute. Broad argues the new interference \u201cchallenges the validity of [UC&#8217;s] eukaryotic claims.\u201d The ruling deems the Broad group the \u201csenior party,\u201d which means UC \u201ccarries the burden of proof\u201d and must convince PTAB that the Broad team did not invent the eukaryotic use of CRISPR.<\/p>\n<p id=\"p-9\">Catherine Coombes, a patent attorney at HGF in York, U.K., who does not represent Broad or UC but is involved in CRISPR patent disputes, says the new interference \u201cadds to the complexity of the landscape.\u201d The European Patent Office has granted what&#8217;s known as \u201coverlapping rights\u201d to both groups and others who have filed CRISPR patent applications, Coombes says\u2014a temporary resolution in anticipation of future legal fights. \u201cFor human therapeutics, it is still too early to know where the key patents will lie,\u201d she adds, noting that CRISPR systems vary, using different enzymes that ultimately may make one version safer or more effective than another.<\/p>\n<p id=\"p-10\">The patent uncertainty created by the new interference declaration may prod UC and Broad to cut a deal, Coombes says. Broad says in a separate statement that it has long hoped UC would enter a \u201cpatent pool,\u201d which effectively would allow both parties to earn money from their inventions without becoming ensnarled in legal wrangling.<\/p>\n<p id=\"p-11\">The parties will discuss the interference with PTAB in a conference call on 5 August. If they do not reach a settlement, the interference hearing is expected in about 8 months.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>(\uc6d0\ubb38: <a href=\"https:\/\/science.sciencemag.org\/content\/365\/6448\/15.2?rss=1\">\uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; A surprise ruling last week reignited the high-profile patent fight over who invented a key application of the genome editor CRISPR. The 3-year-old<a href=\"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3895\" class=\"more-link\">(more&#8230;)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[32,33,34,29,30],"tags":[],"class_list":["post-3895","post","type-post","status-publish","format-standard","hentry","category-essays-on-science","category-do-biology","category-lets-do-chemistry","category-lets-do-science","category-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":2908,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2908","url_meta":{"origin":3895,"position":0},"title":"Making Sense of the CRISPR Patent Dispute Between the University of California and Broad","author":"biochemistry","date":"March 22, 2019","format":false,"excerpt":"\u00a0 \u00a0 Anyone fond of intricate intellectual property disputes (and really, who isn't?) is going to have their cup runnething over when it comes to the long-running battle between the University of California and Harvard\/MIT's Broad Institute to determine who will get to cash in the most on their\u00a0seminal CRISPR\/Cas\u2026","rel":"","context":"In &quot;Essays on Science&quot;","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/ww2.kqed.org\/science\/wp-content\/uploads\/sites\/35\/2039\/02\/DESKTOP_CRISPR_171115-1-1020x677.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/ww2.kqed.org\/science\/wp-content\/uploads\/sites\/35\/2039\/02\/DESKTOP_CRISPR_171115-1-1020x677.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/ww2.kqed.org\/science\/wp-content\/uploads\/sites\/35\/2039\/02\/DESKTOP_CRISPR_171115-1-1020x677.jpg?resize=525%2C300&ssl=1 1.5x"},"classes":[]},{"id":2679,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2679","url_meta":{"origin":3895,"position":1},"title":"Faster, better, cheaper: the rise of CRISPR in disease detection","author":"biochemistry","date":"February 20, 2019","format":false,"excerpt":"\u00a0 \u00a0 Powerful gene-editing tool could help to diagnose illnesses such as Lassa fever early and rein in the spread of infection. \u00a0 Fehintola Ajogbasile, a graduate student at the African Centre of Excellence for Genomics of Infectious Diseases in Nigeria, uses a CRISPR diagnostic test to look for Lassa\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1679,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1679","url_meta":{"origin":3895,"position":2},"title":"\uc720\uc804\uc790 \uac00\uc704 \uc138\uae30\uc758 \ud2b9\ud5c8\u6230 \uc885\uc9c0\ubd80\u2026 &#8220;\ucd5c\ud6c4 \uc2b9\uc790\ub294 MIT\u00b7\ud558\ubc84\ub4dc\ub300&#8221; 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CRISPR: the movie","author":"biochemistry","date":"November 15, 2019","format":false,"excerpt":"\u00a0 \u00a0 The ultimate goal of genome editing is to be able to make any specific change to the blueprint of life. A \u2018search-and-replace\u2019 method for genome editing takes us a giant leap closer to this ambitious goal. \u00a0 \u00a0 Variation in the DNA sequences that constitute the blueprint of\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3992,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3992","url_meta":{"origin":3895,"position":4},"title":"China&#8217;s CRISPR revolution","author":"biochemistry","date":"August 3, 2019","format":false,"excerpt":"\u00a0 \u00a0 Editing of plant, animal, and human genomes has never been easier, as this country's scientists are rapidly demonstrating. \u00a0 FOR MANY PEOPLE, CRISPR plus China equals the biophysicist He Jiankui, who infamously used the genome editor last year to alter the DNA of two human embryos that would\u2026","rel":"","context":"In &quot;Essays on Science&quot;","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4118,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4118","url_meta":{"origin":3895,"position":5},"title":"CRISPR-mediated live imaging of genome editing and transcription","author":"biochemistry","date":"September 23, 2019","format":false,"excerpt":"\u00a0 \u00a0 Tracking nucleic acids in living cells Fluorescence in situ hybridization (FISH) is a powerful molecular technique for detecting nucleic acids in cells. However, it requires cell fixation and denaturation. Wang\u00a0et al.\u00a0found that CRISPR-Cas9 protects guide RNAs from degradation in cells only when bound to target DNA. Taking advantage\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_sharing_enabled":false,"jetpack_shortlink":"https:\/\/wp.me\/p9Xo1j-10P","_links":{"self":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/3895","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3895"}],"version-history":[{"count":1,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/3895\/revisions"}],"predecessor-version":[{"id":3896,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/3895\/revisions\/3896"}],"wp:attachment":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3895"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3895"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3895"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}