{"id":3881,"date":"2019-07-16T12:43:26","date_gmt":"2019-07-16T03:43:26","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=3881"},"modified":"2019-07-16T12:43:26","modified_gmt":"2019-07-16T03:43:26","slug":"caging-cells-in-functional-shells","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3881","title":{"rendered":"Caging cells in functional shells"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>Unprotected cells are sensitive to changes in their environment, including temperature, pH, and osmotic pressure. Zhu\u00a0<em>et al.<\/em>\u00a0have developed a facile route to encapsulating mammalian cells inside functional nanoparticles. A range of nanoparticles, encompassing several types of metal-organic frameworks, mesoporous silica, and iron oxide, were mixed with interparticle ligands to form a shell or exoskeleton around HeLa cells. The rapid complexation of the particles prevented uptake via endocytotic pathways. The cells are then protected from changes in their surrounding conditions, including the presence of toxins and pathogens larger than 5 nanometers, and can be recovered via chelation of the shell. Depending on the choice of nanoparticle, the caged cells can exhibit magnetic, conductive, or fluorescent properties.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p id=\"p-2\"><em>Adv. Mater.<\/em>\u00a0<strong>31<\/strong>, 1900545 (2019).<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>(\uc6d0\ubb38: <a href=\"https:\/\/science.sciencemag.org\/content\/365\/6449\/136.5?rss=1\">\uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; Unprotected cells are sensitive to changes in their environment, including temperature, pH, and osmotic pressure. Zhu\u00a0et al.\u00a0have developed a facile route to encapsulating<a href=\"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3881\" class=\"more-link\">(more&#8230;)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[33,34,29,30],"tags":[],"class_list":["post-3881","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-chemistry","category-lets-do-science","category-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":1220,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1220","url_meta":{"origin":3881,"position":0},"title":"Scissoring genes with light","author":"biochemistry","date":"July 23, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 Nature Chemistry\u00a0volume\u00a010,\u00a0pages\u00a0800\u2013801\u00a0(2018) \u00a0 Enzymes can perform various biological functions because of their delicately and precisely organized structures. Now, simple inorganic nanoparticles with a rationally designed recognition capability can mimic restriction enzymes and selectively cut specific DNA sequences. \u00a0 \u00a0 Designing nanomaterials with properties that enable\u2026","rel":"","context":"In &quot;Let's Do Chemistry!&quot;","block_context":{"text":"Let's Do Chemistry!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=34"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3477,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3477","url_meta":{"origin":3881,"position":1},"title":"Gene editing fixes cystic fibrosis gene in mice before birth","author":"biochemistry","date":"May 9, 2019","format":false,"excerpt":"\u00a0 Administration of nanoparticles\u00a0in utero\u00a0repaired the mutated\u00a0Cftr\u00a0gene \u00a0 The airway of the lungs in cystic fibrosis (pictured here) is clogged with mucus, causing the severe breathlessness seen in this inheritable condition. CNRI\/Science Source \u00a0 \u00a0 Cystic fibrosis, a life-threatening inherited disorder that affects the lungs and other organs, can have\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":976,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=976","url_meta":{"origin":3881,"position":2},"title":"CRISPR with a heart of gold helps ailing mice","author":"biochemistry","date":"June 28, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 \u00a0 Gene-editing molecules ride gold nanoparticles into the brain. \u00a0 Expression of a protein (blue-green, left) associated with fragile X syndrome is suppressed (right) in the brains of mice treated with CRISPR gene-editing molecules. Credit: B. Lee\u00a0et al.\/Nature\u00a0Biomed. Eng. \u00a0 \u00a0 Scientists are mining gold\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4776,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4776","url_meta":{"origin":3881,"position":3},"title":"Smart cancer nanomedicine","author":"biochemistry","date":"November 2, 2019","format":false,"excerpt":"\u00a0 \u00a0 Abstract Nanomedicines are extensively employed in cancer therapy. We here propose four strategic directions to improve nanomedicine translation and exploitation. (1) Patient stratification has become common practice in oncology drug development. Accordingly, probes and protocols for patient stratification are urgently needed in cancer nanomedicine, to identify individuals suitable\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4969,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4969","url_meta":{"origin":3881,"position":4},"title":"Toward a universal flu vaccine","author":"biochemistry","date":"February 24, 2020","format":false,"excerpt":"\u00a0 \u00a0 Influenza virus infections pose a major public health threat, accounting for 3.5 million severe infections and more than 400,000 deaths globally each year (1). Most seasonal vaccines consist of inactivated influenza virus components, which induce antibody responses against immunodominant epitopes in the viral hemagglutinin (HA) and neuraminidase (NA)\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2586,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2586","url_meta":{"origin":3881,"position":5},"title":"Deep learning beats the optical diffraction limit","author":"biochemistry","date":"January 29, 2019","format":false,"excerpt":"\u00a0 \u00a0 A deep learning approach enables up to nine bits of information to be encoded per diffraction-limited area. \u00a0 \u00a0 In our digital age, we generate an ever-increasing amount of data (terabytes per day), making its storage and long-term access increasingly challenging. Hard disk drives have become very popular\u2026","rel":"","context":"In &quot;Let's Do Computer Science!&quot;","block_context":{"text":"Let's Do Computer Science!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=35"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_sharing_enabled":false,"jetpack_shortlink":"https:\/\/wp.me\/p9Xo1j-10B","_links":{"self":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/3881","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3881"}],"version-history":[{"count":1,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/3881\/revisions"}],"predecessor-version":[{"id":3882,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/3881\/revisions\/3882"}],"wp:attachment":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3881"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3881"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3881"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}