{"id":3694,"date":"2019-06-07T15:04:04","date_gmt":"2019-06-07T06:04:04","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=3694"},"modified":"2019-06-07T15:04:04","modified_gmt":"2019-06-07T06:04:04","slug":"%eb%b0%b1%eb%85%84%ec%9d%84-%ec%82%b0%eb%8b%a4%eb%8a%94-%ea%b2%83%ec%9d%98-%ec%9d%98%eb%af%b8","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3694","title":{"rendered":"\ubc31\ub144\uc744 \uc0b0\ub2e4\ub294 \uac83\uc758 \uc758\ubbf8"},"content":{"rendered":"

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\uae40\ud615\uc11d \uc5f0\uc138\ub300\ud559\uad50 \ucca0\ud559\uacfc \uba85\uc608\uad50\uc218. \uc5f0\ud569\ub274\uc2a4 \uc81c\uacf5<\/em><\/span><\/p>\n

 <\/p>\n

2019\ub144 \uc0c8\ud574 \ubcbd\ub450\ubd80\ud130 \ucca0\ud559\uc790 \uae40\ud615\uc11d \uad50\uc218\uac00 \ud654\uc81c\ub2e4. \uc8fc\uc911 5\uc77c\uac04 \ubc29\uc601\ub418\ub294 \ud55c \uc544\uce68\u00a0TV<\/span>\ud504\ub85c\uadf8\ub7a8\uc5d0 \uc8fc\uc778\uacf5\uc73c\ub85c \ub4f1\uc7a5\ud588\ub294\uac00 \ud558\uba74 2016\ub144 \ucd9c\uac04\ud55c \ucc45 \u2018\ubc31\ub144\uc744 \uc0b4\uc544\ubcf4\ub2c8\u2019\uac00 \ub4a4\ub2a6\uac8c \ubca0\uc2a4\ud2b8\uc140\ub7ec\uac00 \ub410\ub2e4. \uc774\ub7f0 \uc778\uae30\ub294 1920\ub144\uc0dd\uc778 \uae40 \uad50\uc218\uac00 \uc62c\ud574 \uc6b0\ub9ac \ub098\uc774\ub85c 100\uc138\uac00 \ub410\uae30 \ub54c\ubb38\uc774\ub2e4. \ud754\ud788\ub4e4 \u2018100\uc138 \uc2dc\ub300\u2019\ub77c\uace0\ub4e4 \ud558\uc9c0\ub9cc \uc2e4\uc81c 100\uc138\uae4c\uc9c0 \uc0b4\uae30\uac00 \uc27d\uc9c0 \uc54a\uae30 \ub54c\ubb38\uc5d0 \uae40 \uad50\uc218\uac00 \ud654\uc81c\uac00 \ub41c \uac83 \uc544\ub2d0\uae4c.<\/p>\n

\uc9c0\uae08\ub3c4 \uc9c0\ud321\uc774\uc5d0 \uc758\uc9c0\ud558\uc9c0 \uc54a\uace0 \uac78\uc73c\uba70 \uac15\uc758\ub3c4 \uc11c\uc11c \ud558\ub294 \uae40 \uad50\uc218\ub97c \ubcf4\uba74\uc11c \u2018\uac74\uac15 100\uc138\u2019\ub77c\ub294 \ub9d0\uc774 \uc2e4\uac10 \ub0ac\ub2e4. \ub298 \uc794\uc794\ud55c \ubbf8\uc18c\ub97c \uc783\uc9c0 \uc54a\uc73c\uba74\uc11c \ucc28\ubd84\ud558\uace0 \uacb8\uc190\ud558\uac8c \ub9d0\ud558\ub294 \uae40 \uad50\uc218\ub97c \ubcf4\uba74 \ub178\uc778\uc740 \ub298\uc5b4\ub3c4 \uc5b4\ub978\uc740 \uc8fc\ub294 \uac83 \uac19\uc740 \uc6b0\ub9ac \uc0ac\ud68c\uc5d0\uc11c \ub098\uc774 \ub4e4\uc5b4\uac00\ub294 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc758 \ub864\ubaa8\ub378\uc774\ub77c\ub294 \uc0dd\uac01\uc774 \ub4e0\ub2e4.<\/p>\n

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\ucca0\ud559\uc790 \uae40\ud615\uc11d \uad50\uc218\uac00 2016\ub144 \ud3b4\ub0b8 \ucc45 \u2018\ubc31\ub144\uc744 \uc0b4\uc544\ubcf4\ub2c8\u2019\uac00 \uc62c\ud574 \ub4e4\uc5b4 \ubca0\uc2a4\ud2b8\uc140\ub7ec\uac00 \ub410\ub2e4. \uc62c\ud574 \uae40 \uad50\uc218\uac00 \uc6b0\ub9ac \ub098\uc774\ub85c 100\uc138\uac00 \ub410\uae30 \ub54c\ubb38\uc774\ub2e4. \uad50\ubcf4\ubb38\uace0 \uc81c\uacf5<\/em><\/span><\/p>\n

 <\/p>\n

\uae40 \uad50\uc218\uc758 \ucc45 \u2018\ubc31\ub144\uc744 \uc0b4\uc544\ubcf4\ub2c8\u2019 \uc5ed\uc2dc \uadf8\uc758 \uc778\ud488\uc774 \uadf8\ub300\ub85c \ub290\uaef4\uc9c0\ub294 \uc794\uc794\ud55c \uc5d0\uc138\uc774\ub85c \uc774\ub904\uc838 \uc788\ub294\ub370 \ub0b4\uc6a9\uc774 \uc720\uc775\ud560 \ubfd0 \uc544\ub2c8\ub77c \uc794\uc7ac\ubbf8\ub3c4 \uaf64 \uc788\ub2e4. \ud2b9\ud788 \uba87 \ub2ec \ub4a4\uba74 \ub9cc 50\uc774 \ub418\ub294 \ud544\uc790\uc5d0\uac8c\ub294 \ud070 \ub3c4\uc6c0\uc774 \ub418\ub294 \uad6c\uc808\uc774 \uc5ec\uae30\uc800\uae30 \ubcf4\uc778\ub2e4.<\/p>\n

\uc608\ub97c \ub4e4\uc5b4 \uae40 \uad50\uc218\ub294 \u201c\uc778\uc0dd\uc5d0\uc11c 50\uc5d0\uc11c 80\uae4c\uc9c0\ub294 \ub2e8\uc808\ub418\uc9c0 \uc54a\uc740 \ud55c \uae30\uac04\uc73c\ub85c \ubcf4\uc544\uc57c \ud55c\ub2e4\u201d\uba70 \u201c50\ubd80\ud130\ub294 \u201880\uc774 \ub418\uc5c8\uc744 \ub54c \ub098\ub294 \uc801\uc5b4\ub3c4 \uc774\ub7ec\ud55c \uc0b6\uc758 \uc870\uac01\ud488\uc744 \uc644\uc131\ud574\uc57c \ud55c\ub2e4\u2019\ub294 \uc900\ube44\uc640 \uacc4\ud68d\uacfc \uc2e0\ub150\uacfc \uafb8\uc900\ud55c \uc6a9\uae30\ub97c \uac16\uace0, \uc81c2\uc758 \ub9c8\ub77c\ud1a4\uc744 \ub2ec\ub9ac\ub294 \uac01\uc624\ub85c \uc7ac\ucd9c\ubc1c\ud574\uc57c \ud55c\ub2e4\u201d\uace0 \uc4f0\uace0 \uc788\ub2e4.<\/p>\n

\uadf8\ub7f0\ub370 \uc625\uc758 \ud2f0\ub77c\uace0 \ud560\uae4c \uae40 \uad50\uc218\uc758 \ucc45\uc5d0\ub294 \uc57d\uac04\uc758 \ubb38\uc81c(?)\uac00 \uc788\ub294 \uac83 \uac19\ub2e4. \ucc45\uc744 \uc77d\ub2e4\ubcf4\uba74 100\uc0b4\uc744 \uc0ac\ub294 \uac8c \ud3c9\ubc94\ud55c \uc77c \uac19\uc740 \uc778\uc0c1\uc744 \ubc1b\uae30 \ub54c\ubb38\uc774\ub2e4. \u2018\uc778\uc0dd\uc5d0\uc11c 50\uc5d0\uc11c 80\uae4c\uc9c0\ub294…\u2019<\/span>\uc774\ub77c\ub294 \uc55e\uc758 \uad6c\uc808\ub9cc \ubd10\ub3c4 \uc6b0\ub9ac\ub098\ub77c \ub0a8\uc131\uc758 \uae30\ub300\uc218\uba85\uc774 80\uc774 \uc548 \ub41c\ub2e4\ub294 \uac78 \uc0dd\uac01\ud558\uba74 \uc2e4\uc81c\ub85c\ub294 \ubc85\ucc2c \uc598\uae30\ub2e4.<\/p>\n

\u2018\uc778\uba85(\u4eba\u547d)\uc740 \uc7ac\ucc9c(\u5728\u5929)\u2019\uc774\ub77c\ub294 \ub9d0\uc774 \uc788\uae30\ub294 \ud558\uc9c0\ub9cc \uadf8\ub798\ub3c4 \uc218\uba85\uc5d0 \uc601\ud5a5\uc744 \uc8fc\ub294 \uc5ec\ub7ec \uc694\uc778\uc774 \uc788\ub2e4. \uc6b0\uc5f0(\uc6b4)\ub3c4 \uc911\uc694\ud558\uc9c0\ub9cc \uac74\uac15\uacfc \uc0dd\ud65c\uc2b5\uad00, \uc720\uc804, \ud658\uacbd \ub4f1\uc774 \ubcf5\ud569\uc801\uc73c\ub85c \uc791\uc6a9\ud55c\ub2e4. \uc9c0\ub09c 100\ub144 \ub3d9\uc548 \uc758\ud559\uc758 \ubc1c\uc804(\uac74\uac15)\uacfc \uc2dd\ub7c9\uc99d\uc0b0 \ubc0f \uc0c1\ud558\uc218\ub3c4\ub97c \ube44\ub86f\ud55c \uc0ac\ud68c\uc778\ud504\ub77c\uc758 \uac1c\uc120(\ud658\uacbd)\uc73c\ub85c \uc9c0\uad6c\ucd0c \uc0ac\ub78c\ub4e4\uc758 \uae30\ub300\uc218\uba85\uc774 \ub450 \ubc30 \uc774\uc0c1 \ub298\uc5c8\ub2e4. \uadf8\ub807\ub2e4\uba74 \uc6b0\ub9ac\uac00 \ud1b5\uc81c\ud560 \uc218 \uc5c6\ub294 \uc720\uc804\uacfc \ud1b5\uc81c\ud560 \uc218 \uc788\ub294 \uc0dd\ud65c\uc2b5\uad00\uc740 \uc218\uba85\uc5d0 \uc5bc\ub9c8\ub098 \uc601\ud5a5\uc744 \ubbf8\uce60\uae4c.<\/p>\n

 <\/p>\n

\uc0c1\uc704 10%\uc640 \ud558\uc704 10% \uc218\uba85 5\ub144 \ucc28\uc774\ub098<\/strong><\/p>\n

\ud559\uc220\uc9c0 \u2018\uc774\ub77c\uc774\ud504(eLife<\/span>)\u2019 1\uc6d4 15\uc77c\uc790\uc5d0\ub294 \uc720\uc804\uc790\uac00 \uae30\ub300\uc218\uba85\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ubd84\uc11d\ud55c \ub17c\ubb38\uc774 \uc2e4\ub838\ub2e4. \uc601\uad6d \uc5d0\ub518\ubc84\ub7ec\ub300 \ub4f1 \ub2e4\uad6d\uc801 \uacf5\ub3d9\uc5f0\uad6c\uc790\ub4e4\uc740 100\ub9cc \uba85\uc774 \ub118\ub294 \uc0ac\ub78c\ub4e4\uc758 \uc218\uba85 \ub370\uc774\ud130\uc640 \uc774\ub4e4 \uc790\ub140\uc758 \uac8c\ub188\uc744 \ubd84\uc11d\ud574 \uc218\uba85\uacfc \uad00\ub828\ub41c \uc720\uc804\uc790\ub97c \ucc3e\uc558\uace0 \uadf8 \uc601\ud5a5\ub825\uc744 \ud3c9\uac00\ud588\ub2e4. \u2018\uc65c \ub2f9\uc0ac\uc790\ub4e4\uc758 \uac8c\ub188\uc774 \uc544\ub2c8\ub77c \uc790\ub140\uc758 \uac8c\ub188\uc744 \ubd84\uc11d\ud588\uc9c0?\u2019<\/span>\u00a0\uc774\ub7f0 \uc758\ubb38\uc774 \ub4e4 \ud150\ub370 \ub2e4 \uc774\uc720\uac00 \uc788\ub2e4.<\/p>\n

 <\/p>\n

\"\"<\/span><\/p>\n

\uc720\uc804\uc790 \ubcc0\uc774\ud615(\ub300\ub9bd\ud615\uc9c8)\uacfc \uc9c8\ubcd1 \uc704\ud5d8\uc131 \ubc0f \uc218\uba85\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ubcf4\uc5ec\uc8fc\ub294 \uadf8\ub798\ud504\ub2e4. \uc67c\ucabd\ubd80\ud130 \uc54c\uce20\ud558\uc774\uba38\ubcd1\/\ud30c\ud0a8\uc2a8\ubcd1, \ud761\uc5f0\/\ud3d0\uc554, \uc2ec\ud608\uad00\uacc4\uc9c8\ud658, 2\ud615 \ub2f9\ub1e8\ubcd1, \uae30\ud0c0 \uc554\uc774\ub2e4.\u00a0APOE<\/span>\u00a0\uc720\uc804\uc790\uc758 \ubcc0\uc774\ud615(\u03b54)\uc740 \uc54c\uce20\ud558\uc774\uba38\ubcd1\/\ud30c\ud0a8\uc2a8\ubcd1\uacfc \uc2ec\ud608\uad00\uacc4\uc9c8\ud658 \uc704\ud5d8\uc131\uc744 \ub192\uc5ec \uc218\uba85\uc5d0 \uaf64 \uc601\ud5a5\uc744 \ubbf8\uce68\uc744 \uc54c \uc218 \uc788\ub2e4. \ubc18\uba74 \uae30\ud0c0 \uc554 \ubc1c\uc0dd \uc704\ud5d8\uc131\uc744 \ub0ae\ucd94\ub294\u00a0ATXN<\/span>2\/BRAP<\/span>\u00a0\uc720\uc804\uc790\uc640\u00a0CDKN<\/span>2B-AS<\/span>1 \uc720\uc804\uc790\uc758 \ubcc0\uc774\ud615\uc740 \uc2ec\ud608\uad00\uc9c8\ud658\uc758 \uc704\ud5d8\uc131\uc740 \ub192\uc774\uae30 \ub54c\ubb38\uc5d0 \uc218\uba85\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc774 \uc0c1\uc1c4\ub41c\ub2e4. \u2018\uc774\ub77c\uc774\ud504\u2019 \uc81c\uacf5<\/em><\/span><\/p>\n

 <\/p>\n

\uc774\ubc88 \uc5f0\uad6c\uc758 \ubc14\ud0d5\uc774 \ub418\ub294 \ub370\uc774\ud130\ub294 \ud604\uc7ac \uc601\uad6d\uc774 \uc57c\uc2ec \ucc28\uac8c \ucd94\uc9c4\ud558\uace0 \uc788\ub294 \u2018\uc601\uad6d \ubc14\uc774\uc624\ubc45\ud06c(UK<\/span>\u00a0Biobank<\/span>)\u2019\uc5d0\uc11c \uc5bb\uc5c8\ub2e4. \uc601\uad6d \ubc14\uc774\uc624\ubc45\ud06c\ub294 2010\ub144 \uae30\uc900 40~69\uc138\uc778 \uc601\uad6d\uc778 50\ub9cc \uba85\uc5d0\uac8c\uc11c \uc5bb\uc740 \uac8c\ub188 \ub370\uc774\ud130\ub97c \uacf5\uac1c\ud574(\ubb3c\ub860 \ub3d9\uc758 \uc544\ub798) \uc758\ud559\uc744 \ube44\ub86f\ud55c \uc5ec\ub7ec \uc601\uc5ed\uc5d0\uc11c \ud65c\uc6a9\ud560 \uc218 \uc788\uac8c \ud55c \ud504\ub85c\uc81d\ud2b8\ub2e4.<\/p>\n

\uadf8\ub7f0\ub370 \uc774\ub4e4\uc758 \uac8c\ub188 \ub370\uc774\ud130\ub85c \uc218\uba85 \uad00\ub828 \uc5f0\uad6c\ub97c \ud558\uae30\uc5d0\ub294 \uc544\uc9c1 \uc774\ub974\ub2e4. \ub4f1\ub85d\uc790 50\ub9cc \uba85 \ub300\ub2e4\uc218\uac00 \uc544\uc9c1 \uc0dd\uc874\ud574 \uc788\uae30 \ub54c\ubb38\uc774\ub2e4. \ub530\ub77c\uc11c \uadf8 \ub300\uc548\uc73c\ub85c \uc774\ub4e4\uc758 \ubd80\ubaa8 \uc218\uba85 \ub370\uc774\ud130\ub97c \ub4e4\uc5ec\ub2e4\ubcf8 \uac83\uc774\ub2e4. \ubb3c\ub860 \ubd80\ubaa8\uc640 \uc790\uc2dd\uc740 \uc720\uc804\uc790\uac00 50%\ub9cc \ub3d9\uc77c\ud558\uc9c0\ub9cc \ub9ce\uc740 \uc0ac\ub78c\uc744 \ub300\uc0c1\uc73c\ub85c \ud1b5\uacc4\ucc98\ub9ac\ub97c \ud558\uba74 \uc758\ubbf8\uc788\ub294 \uacb0\uacfc\ub97c \uc5bb\uc744 \uc218 \uc788\ub2e4.<\/p>\n

\uc774\ub4e4\uc758 \ubd80\ubaa8 100\ub9cc\uc5ec \uba85 \uac00\uc6b4\ub370 60%\uac00 \uc0ac\ub9dd\ud588\ub2e4. \uc774\ub4e4\uc758 \uc218\uba85 \ub370\uc774\ud130\uc640 \uc790\ub140\uc758 \uac8c\ub188 \ub370\uc774\ud130\ub97c \ubd84\uc11d\ud55c \uacb0\uacfc \uc218\uba85\uacfc \uad00\ub828\uc774 \uc788\ub294 \uc720\uc804\uc790 \ub610\ub294 \uc720\uc804\uc790 \uadfc\ucc98\uc758\u00a0SNP<\/span>(\ub2e8\uc77c\uc5fc\uae30\ub2e4\ud615\uc131. \uac1c\uc778\uc5d0 \ub530\ub77c\u00a0DNA<\/span>\uc5fc\uae30\uc11c\uc5f4\uc774 \ub2e4\ub978 \uc9c0\uc810)\ub97c 12\uac1c \ucc3e\uc558\ub2e4.<\/p>\n

\uc774 \uac00\uc6b4\ub370\ub294\u00a0APOE<\/span>\u00a0\uc720\uc804\uc790\ucc98\ub7fc \uc218\uba85\uacfc \uc5f0\uad00\uc131\uc774 \ub192\ub2e4\uace0 \ub110\ub9ac \uc54c\ub824\uc9c4 \uc720\uc804\uc790(\uc2e0\uacbd\uc815\uc2e0\uc9c8\ud658 \ubc0f \uc2ec\ud608\uad00\uc9c8\ud658)\ub3c4 \uc788\uc5c8\uace0\u00a0MAGI<\/span>3 \uc720\uc804\uc790(\uc790\uac00\uba74\uc5ed\uc9c8\ud658)\ucc98\ub7fc \ucc98\uc74c \ubc1d\ud600\uc9c4 \uac83\ub4e4\ub3c4 \uc788\uc5c8\ub2e4. \uc774\ub4e4\uc740 \uc720\uc804\ud615\uc5d0 \ub530\ub77c \uc9e7\uac8c\ub294 3\uac1c\uc6d4\uc5d0\uc11c \uae38\uac8c\ub294 13\uac1c\uc6d4\uae4c\uc9c0 \uc218\uba85\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uac83\uc73c\ub85c \ubd84\uc11d\ub410\ub2e4.<\/p>\n

\uc774\ucc98\ub7fc \uac1c\ubcc4 \uc720\uc804\uc790\uc758 \uc601\ud5a5\ub825\uc744 \ubd84\uc11d\ud55c \uac83\uacfc \ubcc4\ub3c4\ub85c \uc5f0\uad6c\uc790\ub4e4\uc740 \ub2e4\uc911\uc720\uc804\uc790\uc704\ud5d8\uc810\uc218(polygenic<\/span>\u00a0risk<\/span>\u00a0score.<\/span>\u00a0\uc57d\uc790\ub85c\u00a0PRS<\/span>)\ub3c4 \uc0b0\ucd9c\ud588\ub2e4.\u00a0PRS<\/span>\ub294 \ucd5c\uadfc \uac1c\ubc1c\ub41c \ubd84\uc11d\ubc95\uc73c\ub85c, \uc5b4\ub5a4 \ud2b9\uc131(\uc5ec\uae30\uc11c\ub294 \uc218\uba85)\uc5d0 \ud55c \uac1c\uc778\uc758 \uc804\uccb4 \uc720\uc804\uc790\uac00 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \uc218\uce58\ud654\ud55c \uac83\uc774\ub2e4.<\/p>\n

\ub2e4\uc911\uc720\uc804\uc790\uc704\ud5d8\uc810\uc218 \uc0c1\uc704 10%\uc778 \uadf8\ub8f9\uacfc \ud558\uc704 10%\uc778 \uadf8\ub8f9\uc758 \uae30\ub300\uc218\uba85\uc744 \ube44\uad50\ud558\uc790 5\ub144 \uc815\ub3c4 \ucc28\uc774\uac00 \ub0ac\ub2e4. \uc7a5\uc218\uc5d0 \uc720\ub9ac\ud55c \uc720\uc804\uc790 \uc870\ud569\uc744 \ud0c0\uace0 \ub098\uba74 \ubd88\ub9ac\ud55c \uc870\ud569\uc744 \uc9c0\ub2cc \uc0ac\ub78c\uc5d0 \ube44\ud574 5\ub144\uc740 \ub354 \uc0b0\ub2e4\ub294 \ub9d0\uc774\ub2e4. \u2018\uaca8\uc6b0 5\ub144?\u2019<\/span>\u00a0\uc774\ub807\uac8c \uc0dd\uac01\ud558\ub294 \ub3c5\uc790\ub4e4\ub3c4 \uc788\uc744 \ud150\ub370, \uc0ac\uc2e4 \uc720\uc804\uc790\uac00 \uc218\uba85\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc740 \uc2e0\uccb4\ud2b9\uc131\uc774\ub098 \uc131\uaca9\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\ubcf4\ub2e4 \uc801\ub2e4.<\/p>\n

2000\ub144 \uc778\uac04\uac8c\ub188\ucd08\uc548\uc774 \ubc1c\ud45c\ub41c \uc774\ub798 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc774 \u2018\uc7a5\uc218 \uc720\uc804\uc790\u2019 \uc0ac\ub0e5\uc5d0 \ub6f0\uc5b4\ub4e4\uc5c8\uc9c0\ub9cc \uae30\uaecf\ud574\uc57c 1\ub144 \uc815\ub3c4 \uc601\ud5a5\uc744 \uc8fc\ub294 \uc720\uc804\uc790\ub97c \ucc3e\ub294\ub370 \uadf8\ucce4\ub2e4. \uc9c0\uae08\uae4c\uc9c0 \uc5f0\uad6c\uacb0\uacfc\ub97c \uc885\ud569\ud558\uba74 \uc218\uba85\uc5d0 \uc720\uc804\uc790\uac00 \ubbf8\uce58\ub294 \uc601\ud5a5\uc740 16~25%\ub85c \ucd94\uc815\ud558\uace0 \uc788\ub294\ub370, \ucd5c\uadfc\uc5d0\ub294 7% \ubbf8\ub9cc\uc774\ub77c\ub294 \ucda9\uaca9\uc801\uc778 \uc5f0\uad6c\uacb0\uacfc\uac00 \ub098\uc624\uae30\ub3c4 \ud588\ub2e4.<\/p>\n

\uc774\ucc98\ub7fc \uc720\uc804\uc790\uac00 \uc218\uba85\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\ub825\uc774 \ud0a4 \uac19\uc740 \ud2b9\uc131\uc5d0 \ube44\ud574 \uc791\uc740 \uac74 \uc218\uba85\uc774 \ubc88\uc2dd\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc774 \uc81c\ud55c\uc801\uc774\uae30 \ub54c\ubb38\uc774\ub2e4. \uc790\uc2dd\uc744 \ub0b3\uace0 \ud0a4\uc6b0\ub294 \uae30\uac04\uc778 60\uc138 \uc815\ub3c4\uae4c\uc9c0\ub9cc \uc218\uba85\uc774 \ubcf4\uc7a5\ub418\uba74 \uc6b0\ub9ac \uc885\uc774 \uc0dd\uc874\ud558\ub294 \ub370 \ubcc4 \uc9c0\uc7a5\uc774 \uc5c6\uae30 \ub54c\ubb38\uc5d0 100\uc0b4\uae4c\uc9c0 \ubb34\ubcd1\uc7a5\uc218\ud560 \uc218 \uc788\ub294 \uc720\uc804\uc790\uc870\ud569\uc774 \uc9c4\ud654\ud560 \uc774\uc720\uac00 \uc5c6\ub2e4.<\/p>\n

\ud55c \uc720\uc804\uc790\uac00 \ub450 \uc5bc\uad74\uc744 \uc9c0\ub2c8\ub294 \uac83\ub3c4 \uc218\uba85\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ubc18\uac10\uc2dc\ud0a4\ub294 \uc694\uc778\uc774\ub2e4. \uc608\ub97c \ub4e4\uc5b4 \uc774\ubc88 \uc5f0\uad6c\uacb0\uacfc \uc554 \uad00\ub828 \uc720\uc804\uc790 \uac00\uc6b4\ub370\ub294 \ud3d0\uc554 \uc704\ud5d8\uc131\uacfc \uad00\ub828\ub41c\u00a0CHRNA<\/span>3\/5 \uc720\uc804\uc790\ub9cc\uc774 \uc720\uc758\ubbf8\ud558\uac8c \uc218\uba85\uc5d0 \uc601\ud5a5\uc744 \ubbf8\ucce4\ub2e4. \ubc18\uba74\u00a0ATXN<\/span>2\/BRAP<\/span>\u00a0\uc720\uc804\uc790\uc640\u00a0CDKN<\/span>2B-AS<\/span>1 \uc720\uc804\uc790\ub294 \uc554 \uc704\ud5d8\uc131\uc744 \ub0ae\ucd94\ub294 \uc720\uc804\ud615\uc774 \uc2ec\ud608\uad00\uc9c8\ud658 \uc704\ud5d8\uc131\uc740 \ub192\uc774\uae30 \ub54c\ubb38\uc5d0 \uacb0\uad6d \ud6a8\uacfc\uac00 \uc0c1\uc1c4\ub3fc \uc218\uba85\uc5d0\ub294 \ubcc4 \uc601\ud5a5\uc744 \uc8fc\uc9c0 \ubabb\ud55c\ub2e4.<\/p>\n

 <\/p>\n

\uc0dd\ud65c\uc2b5\uad00\uc774 10\ub144 \uc774\uc0c1 \uc88c\uc6b0<\/strong><\/p>\n

\uadf8\ub807\ub2e4\uba74 \uc6b0\ub9ac\uac00 \ud1b5\uc81c\ud560 \uc218 \uc788\ub294 \ubcc0\uc218\uc778 \uc0dd\ud65c\uc2b5\uad00\uc740 \uc218\uba85\uc5d0 \uc5bc\ub9c8\ub098 \uc601\ud5a5\uc744 \ubbf8\uce60\uae4c.<\/p>\n

\ud559\uc220\uc9c0 \u2018\ud608\uc561\uc21c\ud658(Circulation<\/span>)\u2019 2018\ub144 7\uc6d4 24\uc77c\uc790\uc5d0\ub294 \uc0dd\ud65c\uc2b5\uad00\uc5d0 \ub530\ub978 50\uc138 \ubbf8\uad6d\uc778\uc758 \uae30\ub300\uc5ec\uba85\uc744 \uc608\uce21\ud55c \uc5f0\uad6c\uacb0\uacfc\uac00 \uc2e4\ub838\ub2e4. \uc5f0\uad6c\uc790\ub4e4\uc740 5\uac00\uc9c0 \uc0dd\ud65c\uc2b5\uad00\uc744 \u2018\uc88b\uc74c\u2019\uacfc \u2018\ub098\uc068\u2019 \ub450 \uac00\uc9c0\ub85c \ub098\ub208 \ub4a4 \uc2b5\uad00\uc774 \uc218\uba85\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744 \ubd84\uc11d\ud588\ub2e4. 5\uac00\uc9c0 \uc0dd\ud65c\uc2b5\uad00 \uac00\uc6b4\ub370 \uc88b\uc740 \ucabd\uc740 \uae08\uc5f0, \uccb4\uc9c8\ub7c9\uc9c0\uc218 \ubcf4\ud1b5\ubc94\uc704(18.5~24.9), \ud558\ub8e8\ud3c9\uade0 30\ubd84 \uc774\uc0c1 \uc2e0\uccb4\ud65c\ub3d9, \uc801\ub2f9\ud55c \uc74c\uc8fc, \uc591\uc9c8\uc758 \uc2dd\ub2e8\uc774\ub2e4.<\/p>\n

\"\"<\/span><\/p>\n

5\uac00\uc9c0 \uc0dd\ud65c\uc2b5\uad00 \uac00\uc6b4\ub370 \uc88b\uc740 \ucabd\uc744 \uc9c0\ub2cc \uac8c \ub9ce\uc744\uc218\ub85d 50\uc138\uc758 \uae30\ub300\uc5ec\uba85\uc774 \ub298\uc5b4\ub09c\ub2e4. (\uc704 \uadf8\ub9bc)\uc740 \uc5ec\uc131\uc73c\ub85c 5\uac00\uc9c0 \ub2e4 \ub098\uc05c \ucabd\uc5d0 \ube44\ud574 \ub2e4 \uc88b\uc740 \ucabd\uc774 14\ub144\uc774\ub098 \ub354 \uae38\ub2e4. (\uc544\ub798\uadf8\ub9bc)\uc740 \ub0a8\uc131\uc73c\ub85c 5\uac00\uc9c0 \ub2e4 \ub098\uc05c \ucabd\uc5d0 \ube44\ud574 \ub2e4 \uc88b\uc740 \ucabd\uc774 12.2\ub144\uc774 \ub354 \uae38\ub2e4. \u2018\ud608\uc561\uc21c\ud658\u2019 \uc81c\uacf5<\/em><\/span><\/p>\n

 <\/p>\n

\uc5f0\uad6c\uc790\ub4e4\uc740 1980~2014\ub144, 1986~2014\ub144\uae4c\uc9c0 \uc2e4\uc2dc\ub41c \uc7a5\uae30\uac04 \ucd94\uc801 \uc5f0\uad6c\uc758 \ub370\uc774\ud130\ub97c \ubd84\uc11d\ud588\ub2e4. \uc2dc\uc791\ud560 \ub54c 12\ub9cc3219\uba85\uc5d0\uc11c \ucd5c\ub300 34\ub144\uc774 \uc9c0\ub098\ub294 \uc0ac\uc774 4\ub9cc2167\uba85\uc774 \uc0ac\ub9dd\ud588\ub2e4. \uc774\ub4e4\uc740 \uc124\ubb38\uc870\uc0ac\ub97c \ud1b5\ud574 5\uac00\uc9c0 \uc0dd\ud65c\uc2b5\uad00\uc5d0 \ub300\ud574 \ub2f5\ud588\ub2e4. \ub530\ub77c\uc11c \uc218\uba85\uacfc \uc0dd\ud65c\uc2b5\uad00\uc758 \uad00\uacc4\ub97c \ucd94\uce21\ud560 \uc218 \uc788\uc5c8\ub2e4.<\/p>\n

\uadf8 \uacb0\uacfc 5\uac00\uc9c0 \ubaa8\ub450 \uc88b\uc740 \uc0dd\ud65c\uc2b5\uad00\uc744 \uc2e4\ucc9c\ud558\ub294 50\uc138 \uc5ec\uc131\uc758 \uae30\ub300\uc5ec\uba85\uc740 43.1\ub144\uc73c\ub85c 5\uac00\uc9c0 \ubaa8\ub450 \ub098\uc05c \uc0dd\ud65c\uc2b5\uad00\uc73c\ub85c \uc0ac\ub294 50\uc138 \uc5ec\uc131\uc758 \uae30\ub300\uc5ec\uba85 29\uc138\ubcf4\ub2e4 \ubb34\ub824 14\ub144\uc774\ub098 \ub354 \uae38\uc5c8\ub2e4. \ub0a8\uc131 \uc5ed\uc2dc 5\uac00\uc9c0 \ubaa8\ub450 \uc88b\uc740 \uc2b5\uad00\uc774 37.6\ub144\uc73c\ub85c 5\uac00\uc9c0 \ubaa8\ub450 \ub098\uc05c \uc2b5\uad00\uc758 25.5\ub144\ubcf4\ub2e4 12.2\ub144\ub354 \uae38\uc5c8\ub2e4.<\/p>\n

\ub17c\ubb38\uc5d0\uc11c \uc5f0\uad6c\uc790\ub4e4\uc740 \u201c5\uac00\uc9c0 \ubaa8\ub450 \uc88b\uc740 \uc0dd\ud65c\uc2b5\uad00\uc744 \uc9c0\ub2cc \uc0ac\ub78c\uc758 \ube44\uc728\uc774 30\ub144 \ub9cc\uc5d0 15%\uc5d0\uc11c 8%\ub85c \uc904\uc5c8\ub2e4\u201d\uba70 \u201c2014\ub144 \ubbf8\uad6d\uc758 1\uc778\ub2f9 \uc758\ub8cc\uc9c0\ucd9c\ube44\uac00 9402\ub2ec\ub7ec(\uc57d 1000\ub9cc \uc6d0)\ub85c \uc138\uacc4 1\uc704\uc784\uc5d0\ub3c4 \uae30\ub300\uc218\uba85\uc774 \uc18c\ub4dd\uc774 \ube44\uc2b7\ud55c \ub098\ub77c\ub4e4\ubcf4\ub2e4 \ud720\uc52c \uc9e7\uc740 \uc774\uc720\u201d\ub77c\uace0 \ud574\uc11d\ud588\ub2e4.<\/p>\n

TV<\/span>\uc5d0\uc11c \uae40\ud615\uc11d \uad50\uc218\uc758 \uc77c\uc0c1\uc744 \uc9c0\ucf1c\ubcf4\ub2c8 \uc704\uc758 5\uac00\uc9c0 \uc0dd\ud65c\uc2b5\uad00\uc774 \ubaa8\ub450 \uc88b\uc740 \ucabd\uc778 \uac83 \uac19\ub2e4(\uc220\uc740 \uc798 \ubaa8\ub974\uaca0\uc9c0\ub9cc \ucd5c\uc18c\ud55c \uacfc\uc74c\uc740 \uc544\ub2d0 \uac83\uc774\ub2e4). \uae40 \uad50\uc218\uc758 \uac8c\ub188\uc744 \ubd84\uc11d\ud574 \ub2e4\uc911\uc720\uc804\uc790\uc704\ud5d8\uc810\uc218\ub97c \ub0b4\ubcf4\uba74 \uc0c1\uc704 10%\uc5d0 \ub4e4\uc9c0 \uc54a\uc744\uae4c(\uc5b4\uba38\ub2c8\ub3c4 101\uc138\uae4c\uc9c0 \uc0ac\uc168\ub2e4). \uadf8\ub9ac\uace0 \uc6b4\ub3c4 \uae40 \uad50\uc218\uc758 \ud3b8\uc778 \uac83 \uac19\ub2e4(\uc2ec\uac01\ud55c \uc0ac\uace0\ub098 \uc784\uc758\uc758 \ub3cc\uc5f0\ubcc0\uc774\ub85c \uc778\ud55c \uc554 \ubc1c\uc0dd \ub4f1\uc744 \ud53c\ud588\ub2e4). \ubc31\ub144\uc744 \uc0b0\ub2e4\ub294 \uac8c \uc5b4\ub514 \uc26c\uc6b4 \uc77c\uc778\uac00.<\/p>\n

\uadf8\ub7ec\ub098 \uc815\uc791 \uae40 \uad50\uc218\ub294 \ucc45\uc5d0\uc11c \u201c\uc77c\uc740 \ubaa9\uc801\uc774\uace0 \uac74\uac15\uc740 \uc218\ub2e8\u201d\uc774\ub77c\uba74\uc11c\ub3c4 \u201c\uac74\uac15\uc774 \uc77c\uc744 \ub3c4\uc654\ub294\uc9c0 \uc77c\uc774 \uac74\uac15\uc744 \ub3c4\uc654\ub294\uc9c0 \ubb3b\uace0 \uc2f6\ub2e4\u201d\uace0 \uc4f0\uace0 \uc788\ub2e4. \uadf8\ub9ac\uace0 \uc774\uc5b4\uc11c \u201c\uc77c\uc774 \ub0b4 \uac74\uac15\uc744 \uc720\uc9c0\ud574\uc8fc\uc5c8\ub2e4\uace0 \ubbff\uace0 \uc788\ub2e4\u201d\uace0 \ub367\ubd99\uc600\ub2e4. \uacc4\uc18d \uc77c\uc744 \ud55c \uac8c \uc7a5\uc218\uc758 \ube44\uacb0\uc774\ub77c\ub294 \ub9d0\uc774\ub2e4.<\/p>\n

\uadf8\ub7ec\uace0 \ubcf4\uba74 \uc7a5\uc218\ud55c \ucca0\ud559\uc790\ub4e4\uc740 \ub2e4\ub4e4 \uc77c\uc744 \uc88b\uc544\ud588\ub358 \uac83 \uac19\ub2e4. 20\uc138\uae30 \uc804\ubc18\uc744 \ud48d\ubbf8\ud55c \ud504\ub791\uc2a4\uc758 \ucca0\ud559\uc790 \uc559\ub9ac \ubca0\ub974\uadf8\uc190(1859~1941)\uc740 \uc5b4\ub290 \ub0a0 \u201c\ub2f9\uc2e0\uc758 \uc0b6\uc744 \uc694\uc57d\ud574 \ub2ec\ub77c\u201d\ub294 \uae30\uc790\ub4e4\uc758 \uc694\uccad\uc5d0 \ub2e8 \uc138 \ub2e8\uc5b4\ub85c \ub2f5\ud588\ub2e4\uace0 \ud55c\ub2e4.<\/p>\n

\u201c\ud0dc\uc5b4\ub098\uc11c \uc77c\ud558\ub2e4 \uc8fd\uc5c8\ub2e4.\u201d<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

    \uae40\ud615\uc11d \uc5f0\uc138\ub300\ud559\uad50 \ucca0\ud559\uacfc \uba85\uc608\uad50\uc218. \uc5f0\ud569\ub274\uc2a4 \uc81c\uacf5   2019\ub144 \uc0c8\ud574 \ubcbd\ub450\ubd80\ud130 \ucca0\ud559\uc790 \uae40\ud615\uc11d \uad50\uc218\uac00 \ud654\uc81c\ub2e4. \uc8fc\uc911 5\uc77c\uac04 \ubc29\uc601\ub418\ub294 \ud55c \uc544\uce68\u00a0TV\ud504\ub85c\uadf8\ub7a8\uc5d0 \uc8fc\uc778\uacf5\uc73c\ub85c \ub4f1\uc7a5\ud588\ub294\uac00 \ud558\uba74 2016\ub144(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[32,33,29],"tags":[],"class_list":["post-3694","post","type-post","status-publish","format-standard","hentry","category-essays-on-science","category-do-biology","category-lets-do-science"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":3651,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3651","url_meta":{"origin":3694,"position":0},"title":"\uace0\uccb4\uc774\uba74\uc11c \ub3d9\uc2dc\uc5d0 \ucd08\uc720\uccb4\uc778 \ubb3c\uc9c8\uc740 \uc815\ub9d0 \uc874\uc7ac\ud560\uae4c","author":"biochemistry","date":"June 6, 2019","format":false,"excerpt":"\u00a0 \u00a0 \ucd08\uace0\uccb4 \uc2e4\ud5d8\uc758 \ud575\uc2ec \ubd80\ud488\uc778 \u2018\ube44\ud2c0\ub9bc \uc9c4\ub3d9\uc790\u2019.\u00a0\uadf8 \ub4a4\ub85c\u00a0KAIST\u00a0\ubb3c\ub9ac\ud559\uacfc \uae40\uc740\uc131 \uad50\uc218\uc758 \ubaa8\uc2b5\uc774 \ubcf4\uc778\ub2e4. \uacfc\ud559\ub3d9\uc544 \uc81c\uacf5 \u00a0 \u00a0 2000\ub144\ub300 \ub4e4\uc5b4 \uaca9\ub144\uc73c\ub85c \ub178\ubca8 \uacfc\ud559\uc0c1\uc744 \ubc1b\ub2e4\uc2dc\ud53c \ud558\ub2e4 \ubcf4\ub2c8 \uc77c\ubcf8\uc778 \uc218\uc0c1\uc790\uac00 25\uba85\uc5d0 \uc774\ub978\ub2e4. \uc774 \uac00\uc6b4\ub370 \ud544\uc790\uac00 \uac00\uc7a5 \uae4a\uc740 \uc778\uc0c1\uc744 \ubc1b\uc740 \uc0ac\ub78c\uc740 2008\ub144 \ubb3c\ub9ac\ud559\uc0c1 \uc218\uc0c1\uc790\uc778 \ub9c8\uc2a4\uce74\uc640 \ub3c4\uc2dc\ud788\ub370 \ub098\uace0\uc57c\ub300 \uad50\uc218\ub2e4. 1940\ub144\uc0dd\uc778 \ub9c8\uc2a4\uce74\uc640 \uad50\uc218\ub294 \uc218\uc0c1\uc790\ub85c \uc120\uc815\ub420 \ub54c\uae4c\uc9c0\u2026","rel":"","context":"In "Let's Do Chemistry!"","block_context":{"text":"Let's Do Chemistry!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=34"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1559,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1559","url_meta":{"origin":3694,"position":1},"title":"University clears NgAgo gene-editing study authors of deception & ‘\uc911\uad6d\ud310 \ud669\uc6b0\uc11d \uc0ac\ud0dc’ \ub17c\ub780 “\uc870\uc791 \uc758\ub3c4 \uc5c6\ub2e4” \uacb0\ub860","author":"biochemistry","date":"September 5, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 But an investigation confirmed that the study was flawed. \u00a0 \u00a0 A Chinese university has concluded that the authors of a controversial gene-editing paper that was later retracted did not intend to deceive the scientific community. 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