{"id":3468,"date":"2019-05-07T12:19:42","date_gmt":"2019-05-07T03:19:42","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=3468"},"modified":"2019-05-07T12:19:42","modified_gmt":"2019-05-07T03:19:42","slug":"human-3d-cellular-model-of-hypoxic-brain-injury-of-prematurity","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3468","title":{"rendered":"Human 3D cellular model of hypoxic brain injury of prematurity"},"content":{"rendered":"

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Abstract<\/strong><\/p>\n

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Owing to recent medical and technological advances in neonatal care, infants born extremely premature have increased survival rates1<\/a>,2<\/a><\/sup>. After birth, these infants are at high risk of hypoxic episodes because of lung immaturity, hypotension and lack of cerebral-flow regulation, and can develop a severe condition called encephalopathy of prematurity3<\/a><\/sup>. Over 80% of infants born before post-conception week 25 have moderate-to-severe long-term neurodevelopmental impairments4<\/a><\/sup>. The susceptible cell types in the cerebral cortex and the molecular mechanisms underlying associated gray-matter defects in premature infants remain unknown. Here we used human three-dimensional brain-region-specific organoids to study the effect of oxygen deprivation on corticogenesis. We identified specific defects in intermediate progenitors, a cortical cell type associated with the expansion of the human cerebral cortex, and showed that these are related to the unfolded protein response and changes. Moreover, we verified these findings in human primary cortical tissue and demonstrated that a small-molecule modulator of the unfolded protein response pathway can prevent the reduction in intermediate progenitors following hypoxia. We anticipate that this human cellular platform will be valuable for studying the environmental and genetic factors underlying injury in the developing human brain.<\/p>\n<\/div>\n

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(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

    Abstract Owing to recent medical and technological advances in neonatal care, infants born extremely premature have increased survival rates1,2. After birth, these infants(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[33,35,29,30],"tags":[],"class_list":["post-3468","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-computer-science","category-lets-do-science","category-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":953,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=953","url_meta":{"origin":3468,"position":0},"title":"Gene important in pregnancy shows evolution in action","author":"biochemistry","date":"June 25, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 \u00a0 Childbirth and pregnancy might be influenced by variations in the progesterone-receptor gene, which shows wide diversity in humans. Credit: BSIP\/UIG\/Getty Gene important in pregnancy shows evolution in action Human populations have different forms of a gene encoding a hormone receptor. \u00a0 \u00a0 A pregnancy-related\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1158,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1158","url_meta":{"origin":3468,"position":1},"title":"Histidine metabolism boosts cancer therapy","author":"biochemistry","date":"July 18, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 Clinical use of the anticancer drug methotrexate can be limited by its high toxicity. It emerges that a diet rich in the amino acid histidine increases the effectiveness of methotrexate treatment and lowers toxicity in mice. \u00a0 \u00a0 \u00a0 Methotrexate was one of the first\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":894,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=894","url_meta":{"origin":3468,"position":2},"title":"The battle behind the periodic table\u2019s latest additions","author":"biochemistry","date":"June 15, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 Four new elements were added in 2015 with great fanfare \u2014 but some researchers complain the announcement was premature. \u00a0 \u00a0 \u00a0 Illustration by Karol Banach The mood at B\u00e4ckaskog Castle in southern Sweden should have been upbeat when chemists and physicists gathered there for\u2026","rel":"","context":"In "Let's Do Chemistry!"","block_context":{"text":"Let's Do Chemistry!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=34"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1082,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1082","url_meta":{"origin":3468,"position":3},"title":"Max Planck astrophysicist at centre of bullying allegations speaks up","author":"biochemistry","date":"July 10, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 Top German institute plans to release results of a survey that will shed light on bullying issues. \u00a0 \u00a0 \u00a0 The Max Planck Institute for Astrophysics in Garching, Germany.\u00a0Credit: Ghost writ0r via Wikimedia Commons\/CC BY 4.0 \u00a0 \u00a0 A long-standing saga centring on allegations of\u2026","rel":"","context":"In "Essays on Science"","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2059,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2059","url_meta":{"origin":3468,"position":4},"title":"Towards therapeutic base editing","author":"biochemistry","date":"October 12, 2018","format":false,"excerpt":"\u00a0 \u00a0 \uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~ \u00a0 Base editors function in mouse fetuses and in the livers of adult mice to treat a genetic disorder. \u00a0 \u00a0 The vast majority of genetic diseases are caused by single-nucleotide mutations rather than chromosomal rearrangements or small insertions or deletions (indels) and hence could\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1432,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1432","url_meta":{"origin":3468,"position":5},"title":"An ethical way forward for AI","author":"biochemistry","date":"August 24, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) \u00a0 Science\u00a0\u00a024 Aug 2018: Vol. 361, Issue 6404, pp. 763-765 DOI: 10.1126\/science.361.6404.763-q \u00a0 \u00a0 \u00a0 Artificial intelligence (AI) is becoming prevalent in everyday life. Within the next 5 years, an estimated 55% of households worldwide are expected to own a voice assistant. Furthermore, medical diagnostics,\u2026","rel":"","context":"In "Let's Do Computer Science!"","block_context":{"text":"Let's Do Computer Science!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=35"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_sharing_enabled":false,"jetpack_shortlink":"https:\/\/wp.me\/p9Xo1j-TW","_links":{"self":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/3468","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3468"}],"version-history":[{"count":1,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/3468\/revisions"}],"predecessor-version":[{"id":3469,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/3468\/revisions\/3469"}],"wp:attachment":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3468"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3468"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3468"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}