{"id":3341,"date":"2019-04-18T21:32:05","date_gmt":"2019-04-18T12:32:05","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=3341"},"modified":"2019-04-18T21:32:06","modified_gmt":"2019-04-18T12:32:06","slug":"indigenous-groups-look-to-ancient-dna-to-bring-their-ancestors-home","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3341","title":{"rendered":"Indigenous groups look to ancient DNA to bring their ancestors home"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h5>Local communities and geneticists are working together to sequence DNA from remains that were taken from their homelands decades ago.<\/h5>\n<p>&nbsp;<\/p>\n<div class=\"clear pull--both\">\n<figure class=\"figure\"><picture><img decoding=\"async\" src=\"https:\/\/media.nature.com\/w700\/magazine-assets\/d41586-019-01167-w\/d41586-019-01167-w_16649222.jpg\" alt=\"David Edwards, a Mutthi Mutthi Elde,r prepares to welcome Mungo Man back in a ceremony.\" \/><\/picture>\n<div>\n<div><span style=\"color: #82868b; font-size: 1rem;\">David Edwards, a Mutthi Mutthi elder, welcomes the return of remains that had been taken long ago. Credit: Lisa Maree Williams\/Getty<\/span><\/div>\n<\/div>\n<\/figure>\n<\/div>\n<div class=\"article__aside align-right hide-print\">\n<div class=\"pdf__download shrink--aside\">\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n<div class=\"align-left\">\n<div class=\"article__body serif cleared\">\n<p>Several years ago, Gudju Gudju Fourmile welcomed back several members of his Yidinji community who had been taken from their homes in northern Australia almost a century ago. Like many other Indigenous communities in Australia, the Yidinji have worked for decades to bring the bodies of their ancestors home \u2014 which Aboriginal communities describe as returning to Country.<\/p>\n<p>Many of the ancestors are off Country as a result of the dehumanizing practices of the nineteenth and early twentieth centuries, when it was common for white collectors to loot graves and sell the remains of Aboriginal people to museums in Australia, the United Kingdom and other countries. \u201cWhen our remains are off Country, we try to make sure they come back,\u201d says Fourmile, an elder in the community who lives in Cairns. \u201cThey need to be comfortable. That\u2019s a big thing for many tribal groups.\u201d And when his community finally reburied its ancestors in 2014, \u201ceverybody was so happy. And the Country felt good again,\u201d Fourmile says.<\/p>\n<p>Before the Yidinji elders laid their ancestors to rest, they received a request from scientists who had been analysing the DNA of living community members: could they sequence the ancestors\u2019 genomes, too? With permission granted, a team led by evolutionary geneticist David Lambert at Griffith University in Brisbane extracted DNA from the remains of one individual, and confirmed that the ancient person was closely related to Yidinji people alive today<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-01167-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR1\">1<\/a><\/sup><sup>,<\/sup><sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-01167-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR2\">2<\/a><\/sup>. \u201cWhen you find something out like that, you jump for joy,\u201d says Fourmile. The event also marked a turning point in the mindset of the community, he says, when members started to realize the potential of DNA analysis to help bring their people back home.<\/p>\n<p>In the past 30 years or so, museums have responded to complaints by repatriating thousands of human remains and sacred objects to Indigenous Australian groups such as the Yidinji. But many more \u2014 possibly thousands \u2014 lack the information necessary to return them to one of the dozens of distinct Indigenous groups in Australia. That is a source of great distress for communities. Lambert\u2019s team published a study in 2018 showing that ten remains, including those of one ancient Yidinji individual, could be linked to specific Indigenous communities through genetics<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-01167-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR1\">1<\/a><\/sup>.<\/p>\n<p>Now, two teams in Australia, including Lambert\u2019s, are partnering with Indigenous communities to create genomic maps that connect ancient and historical remains with present-day groups. Such catalogues could eventually be used to help return remains to the right communities.<\/p>\n<p>&nbsp;<\/p>\n<aside class=\"recommended pull pull--left sans-serif\" data-label=\"Related\"><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-01166-x\" data-track=\"click\" data-track-label=\"recommended article\"><img decoding=\"async\" class=\"recommended__image\" src=\"https:\/\/media.nature.com\/w400\/magazine-assets\/d41586-019-01167-w\/d41586-019-01167-w_16658956.jpg\" \/><\/a><\/p>\n<p class=\"recommended__title serif\">Facing up to injustice in genome science<\/p>\n<\/aside>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>Australia is one country where this approach is being trialled. DNA research is confirming that many Indigenous groups have lived on the continent for tens of thousands of years<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-01167-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR2\">2<\/a><\/sup><sup>,<\/sup><sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-01167-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR3\">3<\/a><\/sup>. In some places, it has established that ancient individuals are closely related to present-day groups living in the same region<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-01167-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR1\">1<\/a><\/sup>. Drawing such links in other regions, such as North America, has proved more difficult, because ancient populations there seem to have moved around more.<\/p>\n<p>One of these projects could eventually be used by Indigenous people who are still suffering from past government actions, particularly a racist Australian policy lasting until 1970 that removed thousands of Aboriginal children from their families. These children became known as the \u2018Stolen Generations\u2019, and many of them are alive today. A DNA database of Indigenous groups could help some individuals to understand their genetic heritage and identify their homeland.<\/p>\n<p>But such efforts raise concerns. As a result of the history of mistreatment, some Indigenous people fear that unscrupulous governments or scientists might misuse their genetic information. And there are tensions over who should control the data and whether scientists can freely share genomic sequences.<\/p>\n<p>Fourmile says that Yidinji people agreed to the study because they had control of the data. \u201cWe\u2019ve done a flip, and now we\u2019re wanting them to study us for our own benefit to bring our people home,\u201d he says.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Going back to Country<\/strong><\/p>\n<p>The arrival of European colonizers in Australia in the late 1780s marked the beginning of a scientific grave-robbing era there, when white people collected Indigenous human remains for research \u2014 including now-discredited \u2018racial science\u2019 theories linking intellect with anatomical differences. By the end of the nineteenth century, most major museums around the world housed Indigenous Australian remains.<\/p>\n<p>The collection of such remains was part of the broader subjugation of Indigenous Australians by Europeans, which has led to generational trauma. Authorities determined where people could live and work, whom they could marry and whether they could keep their children. Tribal groups were also systematically moved off their land and placed on reserves and missions, where their movements were restricted. \u201cThey were trying to get us away from our traditional lands,\u201d says Michael Young, a member of the adjoining Paakantyi and Parrintyi tribal groups, which stretch across a large swathe of southwestern New South Wales.<\/p>\n<p>Aboriginal groups began fighting for the return of their ancestors in the 1970s, as part of a wider movement against the ongoing discrimination against them. By the 1980s, the growing pressure prompted some museums to introduce policies to return human remains and sacred objects to their communities.<\/p>\n<p>Tracking down the traditional owners of ancestral remains is important for Aboriginal people because it is part of reclaiming their identities after being forced to assimilate into white Australia, says Young. \u201cRepatriation is healing some of that wrong that has been done to us over the last 230 years,\u201d he says.<\/p>\n<p>So far, Indigenous communities have regained custodianship of more than 2,500 sets of ancestral remains from Australian museums, according to the government\u2019s repatriation programme (see \u2018Mapping ancestors\u2019). And in the past 30 years, more than 1,500 sets of ancestral remains have been returned to Australia, mostly from the United Kingdom, but also from the United States, Canada and half a dozen European nations, although some museums still refuse to repatriate remains and cultural objects.<\/p>\n<p>&nbsp;<\/p>\n<figure class=\"figure\">\n<div class=\"embed intensity--high\">\n<div class=\"embed intensity--high\"><img decoding=\"async\" class=\"figure__image\" src=\"https:\/\/media.nature.com\/w800\/magazine-assets\/d41586-019-01167-w\/d41586-019-01167-w_16652386.png\" alt=\"\" data-src=\"\/\/media.nature.com\/w800\/magazine-assets\/d41586-019-01167-w\/d41586-019-01167-w_16652386.png\" \/><\/div>\n<\/div><figcaption>\n<p class=\"figure__caption sans-serif\">Source: Refs 1 and 3; Australian Govt. Dept. Communication and the Arts<\/p>\n<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>But there are probably several thousand sets of remains in Australian museums whose origin remains unknown, says Deanne Hanchant-Nichols, an anthropologist in Adelaide with experience in trying to identify unprovenanced remains and a member of the Tanganekald and Barkindji (or Paakantyi) communities. Many of the bodies are simply labelled \u2018Aboriginal\u2019, with no other identifying details, she says.<\/p>\n<p>In 2016, Lambert laid the groundwork for ways to solve this problem, as part of a team that was charting the continent\u2019s genetic history<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-01167-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR2\">2<\/a><\/sup>. Lambert worked with elders to collect DNA samples and shared the team\u2019s findings about the ancestry of some contemporary Indigenous Australians. During these conversations, the elders and Lambert discussed whether DNA could also reveal where ancient remains in museums had come from. Lambert said it was possible, but he was cautious not to predict the result before they did the analysis. \u201cWe\u2019ve got to be careful about this kind of research,\u201d he says.<\/p>\n<p>Lambert got permission from the elders of 11 Aboriginal groups, including the Yidinji and the Paakantyi, to test the idea; several members of Indigenous communities, including Fourmile and Young, joined the study as co-authors.\u201d His team sequenced DNA from 27 sets of human remains \u2014 mostly bones, but also teeth and hair \u2014 from individuals who died before British settlers arrived and whose burial location was known<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-01167-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR1\">1<\/a><\/sup>. Most of these remains have been repatriated.<\/p>\n<p>Despite Australia\u2019s sweltering heat, which degrades DNA in remains, the team, co-led by Lambert and evolutionary geneticist Eske Willerslev at the Natural History Museum of Denmark in Copenhagen, obtained mitochondrial genomes from all 27 remains and full or partial nuclear genomes from 10 of them<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-01167-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR1\">1<\/a><\/sup>\u00a0(see \u2018Mapping ancestors\u2019).<\/p>\n<p>The DNA in mitochondria \u2014 cells\u2019 power plants \u2014 is generally inherited maternally and is present in many more copies in cells than nuclear DNA. But Lambert\u2019s team \u2014 which included Joanne Wright, then a PhD student at Griffith University \u2014 found it was of limited use in linking remains to contemporary groups: 11 of the remains had no conclusive match in a database of more than 100 mitochondrial genomes from Indigenous Australians, and two were linked to the wrong geographic area.<\/p>\n<p>Nuclear DNA proved a much richer source of ancestry information for matching remains to present-day communities. Lambert\u2019s team compared the 10 ancient nuclear genomes to those of 100 Indigenous Australians living across the country. In all ten cases, the ancestral remains were most closely related to the Indigenous people in their study who came from the same geographical area.<\/p>\n<p>For instance, one of the ancient individuals is estimated to have lived at least 2,000 years ago, and their remains were excavated from a well-known Aboriginal burial ground in the Willandra Lakes region in far western New South Wales in 1974. The closest relatives of that person are members of the Willandra groups who live in the area today.<\/p>\n<p>Lambert is now negotiating with the Queensland Museum and its board of Indigenous advisers to sequence about 300 unprovenanced remains housed at the museum, to test whether their place of origin can be identified. Young agrees that genetic matching could be a powerful tool for repatriating ancestors to the right community. But he would like to see more proof of its accuracy before the approach is applied to unprovenanced remains. The risk of repatriating remains to the wrong community could be reduced, he adds, by combining genomic analysis with anthropological evidence. Incorporating cultural knowledge from communities and information from museum archives could also help.<\/p>\n<p>Moreover, Young says that such efforts should include more Indigenous scientists, who are aware of the culture and can discuss with communities how the research can help to reinforce their connection to Country. He is working with Lambert and others to set up scholarships for Aboriginal people to study genetics. \u201cI\u2019d love more Aboriginal people to get into that area,\u201d he says.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>A map of the past<\/strong><\/p>\n<p>Isabel O\u2019Loughlin has spent the past six years building trust with several Indigenous communities. She is one of two community consultants working on the Aboriginal Heritage Project, another effort to look at DNA from remains of Indigenous Australians.<\/p>\n<p>The group is sequencing hair samples that were collected mostly by ethnologists Norman Tindale and Joseph Birdsell from 1928 to the 1970s in what are today seen as racially motivated studies.<\/p>\n<p>The Tindale and Birdsell teams drew family trees that name more than 50,000 people, including some who lived before British settlers arrived in 1860. The collection, which is held at the South Australian Museum in Adelaide, also contains photographs, sound recordings, films and drawings. More than 5,000 hair samples are stored in a restricted area in the museum.<\/p>\n<p>&nbsp;<\/p>\n<figure class=\"figure\">\n<div class=\"embed intensity--high\">\n<div class=\"embed intensity--high\"><img decoding=\"async\" class=\"figure__image\" src=\"https:\/\/media.nature.com\/w800\/magazine-assets\/d41586-019-01167-w\/d41586-019-01167-w_16652120.jpg\" alt=\"Willandra Elders visiting the ancient DNA laboratory in 2008.\" data-src=\"\/\/media.nature.com\/w800\/magazine-assets\/d41586-019-01167-w\/d41586-019-01167-w_16652120.jpg\" \/><\/div>\n<\/div><figcaption>\n<p class=\"figure__caption sans-serif\"><span class=\"mr10\">Elders from Indigenous communities from the Willandra Lakes region visiting the ancient DNA laboratory at Griffith University in 2008.<\/span>Credit: Renee Chapman<\/p>\n<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>When ancient-DNA researcher Alan Cooper at the University of Adelaide first heard about the collection a decade ago, he wondered whether it could be used to determine where Aboriginal Australian communities lived before British settlers arrived and spread throughout the country. Although the hair samples were collected from the 1920s \u2014 when Aboriginal people were already being forced from traditional lands \u2014 the detailed family trees meant that the team would be able to trace some people\u2019s families back to these locations. So, in 2014, Cooper\u2019s team started reaching out to Indigenous communities to get permission to analyse the remains.<\/p>\n<p>Lewis O\u2019Brien, an adviser to the Aboriginal Heritage Project, remembers Tindale visiting Point Pearce, the mission where his aunt lived in 1938. Tindale interviewed O\u2019Brien, aged 8, and his brother, and measured their heights and the length of their arms, among other things. Tindale also snipped a lock of O\u2019Brien\u2019s hair. \u201cI felt like a guinea pig,\u201d says O\u2019Brien, an elder with the Kaurna people, who is now 89 and lives in nearby Adelaide. O\u2019Brien didn\u2019t like how Tindale studied Aboriginal people, but he can see that the collection is a valuable resource for unravelling history for some communities.<\/p>\n<p>The project\u2019s data could also be the starting point for creating a service for present-day Indigenous people to compare their DNA against the reference map built from the hair samples. The service could allow some people \u2014 including members of the Stolen Generations \u2014 to explore whether genetics can reveal anything about where they might have come from, when conventional methods of finding such information fail, says Ray Tobler, a population geneticist at the University of Adelaide. But more work to reduce uncertainties is needed before such a service would be possible, he says. Hanchant-Nichols thinks a broad discussion among Indigenous people is needed, too. O\u2019Brien supports a genetic-comparison service. He is often approached by Aboriginal people who were removed from their families and are desperate for information about their ancestry. \u201cI want to be able to say, \u2018we\u2019ll get you tested and help you find out where you come from\u2019,\u201d he says.<\/p>\n<p>Cooper and Tobler also visit communities to explain their efforts. Families whose records form part of the Tindale collection then have private meetings with the team to ask questions and raise any concerns. Some worry that their family\u2019s genetic results could be misused, for instance, by government agencies to test their status as an Aboriginal person, says Cooper. But he says that status is based on community recognition and cannot be defined genetically. There is currently no DNA test of Aboriginality (despite claims to the contrary by some conservative politicians in Australia). The geographical information accompanying the genetic data is not specific enough to resolve land-title claims \u2014 another concern. \u201cTo boil someone\u2019s identity down to their DNA is unethical and scientifically flawed,\u201d adds Tobler.<\/p>\n<p>O\u2019Loughlin says the project has been embraced by the communities largely because Aboriginal people retain control. Of almost 180 families that the team has approached, only two decided not to participate in the project, she says.<\/p>\n<p>After performing the analysis, the team returns with results. The community learns about the history of Australia and the relationships of different Indigenous groups. And individuals get information about their ancestor who provided the hair sample. O\u2019Loughlin and her colleague Amy O\u2019Donoghue also alert families in advance if the results show that biological relationships differ from families\u2019 known relationships.<\/p>\n<p>In 2017, Cooper and Tobler\u2019s team published its first map of Aboriginal groups, based on mitochondrial DNA from 111 hair samples from three Indigenous communities<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-01167-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR3\">3<\/a><\/sup>. The genetic analysis suggests that the first Australians arrived from Asia by about 50,000 years ago. This is broadly in line with most archaeological evidence and previous genome studies<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-01167-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR2\">2<\/a><\/sup>(see \u2018Mapping ancestors\u2019). Australia\u2019s Indigenous groups also say their connection to the continent is ancient. Within a couple of thousand years, this founding group split into populations that expanded west and east \u2014 and then largely stayed put. On the basis of mitochondrial lineages, at least, there hasn\u2019t been a lot of movement around Australia over broad geographical and time scales, says Tobler. \u201cThat\u2019s remarkable because you don\u2019t really see that anywhere else.\u201d<\/p>\n<p>Cooper and his team have now sequenced the nuclear genomes of about 150 hair samples. They plan to seek permission to sequence DNA from up to 1,000 hair samples.<\/p>\n<p>However, the project has been on hold for almost a year while the team has worked to comply with state laws on conducting research with Aboriginal participants. The project is set to resume this month.<\/p>\n<p>Although the hair samples are not being repatriated to the families, the map that is based on their DNA could help to match unprovenanced remains in museums to present-day groups, enabling their return.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Tales of the Ancient One<\/strong><\/p>\n<p>In the United States, the 1990 Native American Graves Protection and Repatriation Act (NAGPRA) and similar state legislation oblige museums to audit their collections and return what they can in the way of ancestral remains and sacred objects to Native American communities.<\/p>\n<p>So far, NAGPRA has led to the return of hundreds of thousands of culturally affiliated ancestral remains and artefacts. And in the past few years, the US government has cited ancestry information gleaned from ancient DNA in returning some unaffiliated remains to tribes.<\/p>\n<p>One of the most contentious is the 8,500-year-old skeleton of \u2018Kennewick Man\u2019, which was uncovered by teenagers in 1996 in a riverbank near Kennewick, Washington. Several Native American groups claimed the remains of the individual, whom they call the Ancient One, as ancestral and demanded their return under NAGPRA. But a coalition of archaeologists argued that the person lived too long ago to be culturally linked to present-day Native Americans under the law, and won a 2002 federal lawsuit to block their repatriation.<\/p>\n<p>The remains were stored out of view in a Seattle museum, available to scientists and Native American groups, for over a decade. But several years ago, the US government asked Willerslev whether his lab could test the remains for DNA. After consulting with all of the Native American groups seeking Kennewick Man\u2019s return, Willerslev\u2019s team obtained enough DNA to generate a low-quality genome sequence.<\/p>\n<p>Comparisons with DNA from present-day individuals confirmed that Kennewick Man was more closely related to Indigenous groups in North and South America than to other global populations<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-01167-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR4\">4<\/a><\/sup>. They also determined that Kennewick Man was closely related to members of the Confederated Tribes of the Colville, who had participated in the study \u2014 one of the five communities seeking repatriation \u2014 but also to other groups in the Pacific Northwest and even to some in Central and South America. On the basis of the DNA tests, the US government determined that Kennewick Man was Native American, and therefore eligible for repatriation under NAGPRA. The remains were reburied in 2017 by members of the Yakama Nation, the Wanapum Band and the Nez Perce, Colville and Umatilla tribes.<\/p>\n<p>The US government again cited ancient DNA evidence generated by Willerslev\u2019s team when repatriating remains from Nevada in 2016, including a 10,600-year-old male human skeleton known as the Spirit Cave Mummy. As with Kennewick Man, the DNA analysis determined that the remains were Native American, but the study did not link them to any specific groups<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-019-01167-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR5\">5<\/a><\/sup>.<\/p>\n<p>Linking ancient remains to present-day groups is challenging because of huge gaps in scientists\u2019 understanding of the population history of the Americas. Few genetic data are available for ancient remains in the Americas, says population geneticist Rasmus Nielsen at the University of California, Berkeley. The preliminary analysis of DNA from remains such as Kennewick Man and Spirit Cave Mummy suggests that ancient populations in the area moved around, so the ancient inhabitants of a region are likely to be the ancestors of many different Native American groups.<\/p>\n<p>Drawing connections between ancient remains and modern groups is even more difficult, because there are relatively few genomes from present-day Native Americans against which to compare ancient remains, Nielsen adds. \u201cGenetic results are only going to be as good as your comparative database,\u201d says Ripan Malhi, a molecular anthropologist at the University of Illinois at Urbana\u2013Champaign, who works with Indigenous groups in North America. The paucity of contemporary Native American genomes is a legacy of the poor treatment of Indigenous groups by non-Indigenous scientists, he adds.<\/p>\n<p>In one case, researchers collected DNA from members of the Havasupai Tribe in Arizona, for health research. But they failed to seek permission when the samples were later used for other kinds of studies, so many Native Americans are now reluctant to share their details.<\/p>\n<p>Some scientists in Australia have also failed to give Indigenous groups proper control over their own data. Such incidents have led to agreements where Indigenous groups decide how their information can be used. For instance, Indigenous communities involved with Lambert\u2019s study permit their data to be shared with other groups wishing to verify the results, but only if the scientists get ethics approval. If researchers want to use the data for other purposes, they must get consent from the participants.<\/p>\n<p>Some researchers have criticized such restrictions, saying that they could prevent Indigenous groups from seeing the benefits of future studies using their data. But Lambert and Indigenous groups say it is about time that non-Indigenous scientists ceded control.<\/p>\n<p>And Aboriginal people are starting to embrace the chance to be involved, says Hanchant-Nichols. \u201cFor many, many years, science kept us out. We had no role in museums other than for them to steal our stories, steal our artefacts and steal our bones.\u201d<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<p><span class=\"emphasis\">Nature<\/span>\u00a0<strong>568<\/strong>, 294-297 (2019)<\/p>\n<p>&nbsp;<\/p>\n<div class=\"emphasis\">doi: 10.1038\/d41586-019-01167-w<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>(\uc6d0\ubb38: <a href=\"https:\/\/www.nature.com\/articles\/d41586-019-01167-w?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29\">\uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; Local communities and geneticists are working together to sequence DNA from remains that were taken from their homelands decades ago. &nbsp; David Edwards,<a href=\"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3341\" class=\"more-link\">(more&#8230;)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[33,29,30],"tags":[],"class_list":["post-3341","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","category-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":957,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=957","url_meta":{"origin":3341,"position":0},"title":"Oaks last 800 years with help of DNA double take","author":"biochemistry","date":"June 25, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 The long lifespan of the pedunculate oak, also known as the English oak, may stem from an extra helping of genes for disease resistance. Credit: Gustaf Emanuelsson\/Folio\/Getty Oaks last 800 years with help of DNA double take Iconic tree may owe its long life to\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2795,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2795","url_meta":{"origin":3341,"position":1},"title":"DNA-based communication in populations of synthetic protocells","author":"biochemistry","date":"March 7, 2019","format":false,"excerpt":"\u00a0 \u00a0 Abstract \u00a0 Developing molecular communication platforms based on orthogonal communication channels is a crucial step towards engineering artificial multicellular systems. Here, we present a general and scalable platform entitled \u2018biomolecular implementation of protocellular communication\u2019 (BIO-PC) to engineer distributed multichannel molecular communication between populations of non-lipid semipermeable microcapsules. Our\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3852,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3852","url_meta":{"origin":3341,"position":2},"title":"Move over, DNA: ancient proteins are starting to reveal humanity\u2019s history","author":"biochemistry","date":"June 27, 2019","format":false,"excerpt":"\u00a0 \u00a0 Proteins dating back more than one million years have been extracted from some fossils, and could help to answer some difficult questions about archaic humans. \u00a0 \u00a0 Homo floresiensis\u00a0is one of the species researchers hope to study by sequencing ancient proteins. Credit: Adapted from World History Archive\/Alamy \u00a0\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2670,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2670","url_meta":{"origin":3341,"position":3},"title":"Revealing a microbial carcinogen","author":"biochemistry","date":"February 15, 2019","format":false,"excerpt":"\u00a0 \u00a0 The microbiota in the human gastrointestinal system is predicted to produce hundreds of unique small molecules and secondary metabolites that may influence host health and disease (1). Many such molecules are produced by sophisticated multienzymatic assembly lines that are encoded by bacterial biosynthetic gene clusters. One class of\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":889,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=889","url_meta":{"origin":3341,"position":4},"title":"DNA\uac00 \ub3cc\uc1e0\ucc98\ub7fc \ud589\ub3d9\ud558\ub294 \ud604\uc0c1 \ubc1c\uacac","author":"biochemistry","date":"June 14, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) \u00a0 \u00a0 [\uc694\uc57d]\ubbf8\uad6d \uacfc\ud559\uc790\ub4e4\uc774 \uc804\ub958\uac00 \ud750\ub974\ub294 \uc824 \uc548\uc5d0\uc11c\u00a0DNA\uac19\uc740 \uac70\ub300 \ubd84\uc790\ub4e4\uc774 \ud655\uc0b0\ub418\uc9c0 \uc54a\uace0 \uace0\uc815\ub3fc \uc788\ub294 \ud604\uc0c1\uc744 \ubc1c\uacac\ud588\ub2e4.\u00a0\uc720\uc804\uc790 \uce58\ub8cc\ub098 \uc57d\ubb3c \uce58\ub8cc \ub4f1\uc5d0\uc11c \uc720\uc6a9\ud558\uac8c \uc751\uc6a9\ub420 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uae30\ub300\ub418\uace0 \uc788\ub2e4.(2018.06) \u00a0 \/NSF \ubbf8\uad6d \uc560\uba38\uc2a4\ud2b8 \ub9e4\uc0ac\ucd94\uc138\uce20\uc8fc\ub9bd\ub300 \uc5f0\uad6c\ud300\uc774 DNA\ucc98\ub7fc \uac70\ub300 \ubd84\uc790\uac00 \ud2b9\ubcc4\ud788 \uc870\uc791\ub41c \uc824 \uc548\uc5d0\uc11c \uace0\uc815\ub3fc \ud655\uc0b0\ud558\uc9c0 \uc54a\ub294 \ud604\uc0c1\uc744 \ubc1c\uacac\ud588\ub2e4.\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxODA2MDlfOTIg\/MDAxNTI4NTEyNTM3MDU4.hsrmk6IlfAIdYUzwMqCRvtA1e6M4RGI7zO1GaIbw6D0g.HPFqPN_zg-QtTc0tFY_dy5v8GFOecviKDxtH741vDf4g.JPEG\/1013genomenew.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxODA2MDlfOTIg\/MDAxNTI4NTEyNTM3MDU4.hsrmk6IlfAIdYUzwMqCRvtA1e6M4RGI7zO1GaIbw6D0g.HPFqPN_zg-QtTc0tFY_dy5v8GFOecviKDxtH741vDf4g.JPEG\/1013genomenew.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxODA2MDlfOTIg\/MDAxNTI4NTEyNTM3MDU4.hsrmk6IlfAIdYUzwMqCRvtA1e6M4RGI7zO1GaIbw6D0g.HPFqPN_zg-QtTc0tFY_dy5v8GFOecviKDxtH741vDf4g.JPEG\/1013genomenew.jpg?resize=525%2C300&ssl=1 1.5x, https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxODA2MDlfOTIg\/MDAxNTI4NTEyNTM3MDU4.hsrmk6IlfAIdYUzwMqCRvtA1e6M4RGI7zO1GaIbw6D0g.HPFqPN_zg-QtTc0tFY_dy5v8GFOecviKDxtH741vDf4g.JPEG\/1013genomenew.jpg?resize=700%2C400&ssl=1 2x"},"classes":[]},{"id":599,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=599","url_meta":{"origin":3341,"position":5},"title":"Fifty years since DNA repair was linked to cancer","author":"biochemistry","date":"May 31, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 In 1968, a defect in DNA repair was found to underlie a disorder that makes people extremely sensitive to sunlight. This finding continues to influence research into the origins, diagnosis and treatment of cancer. \u00a0 \u00a0 Some people are born with exceptional sensitivity to sunlight.\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_sharing_enabled":false,"jetpack_shortlink":"https:\/\/wp.me\/p9Xo1j-RT","_links":{"self":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/3341","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3341"}],"version-history":[{"count":1,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/3341\/revisions"}],"predecessor-version":[{"id":3342,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/3341\/revisions\/3342"}],"wp:attachment":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3341"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3341"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3341"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}