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Abstract Several turn-on RNA aptamers that activate small-molecule fluorophores have been selected in vitro. 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However, their usefulness in the mammalian cell is limited by low expression and rapid degradation. Here we describe the Tornado (Twister-optimized RNA for durable overexpression) expression\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4481,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4481","url_meta":{"origin":3304,"position":2},"title":"RNA therapies explained","author":"biochemistry","date":"October 18, 2019","format":false,"excerpt":"\u00a0 Treatments that target RNA or deliver it to cells fall into three broad categories, with hybrid approaches also emerging. \u00a0 \u00a0 Illustration of messenger RNA (red) produced from a DNA strand (purple).\u00a0Credit: Juan Gaertner\/SPL \u00a0 \u00a0 The conventional view of RNA casts the molecule in a supporting role \u2014\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2732,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2732","url_meta":{"origin":3304,"position":3},"title":"\uc9c0\uad6c \uc0dd\ubb3c DNA\uc640 \ub2e4\ub978 \uc720\uc804 \uc815\ubcf4 \ubd84\uc790\uc2dc\uc2a4\ud15c \ud569\uc131 & Four new DNA letters double life\u2019s alphabet","author":"biochemistry","date":"February 23, 2019","format":false,"excerpt":"\u00a0 \u00a0 \"\ub73b\ubc16\uc758\" \uc678\uacc4\uc0dd\uba85\uccb4 \uac00\ub2a5 \uc785\uc99d\u2026\ud0d0\uc0c9 \ubc29\uc2dd \uc7ac\uac80\ud1a0 \ud544\uc694\uc131 \uc81c\uae30\ub3fc \u00a0 \uc0c8\ub85c \ud569\uc131\ub41c '\ud558\uce58\ubaa8\uc9c0\u00a0DNA'\uae30\uc874 4\uac1c \uc694\uc18c(\uc801\uc0c9\u00b7\ub179\uc0c9\u00b7\uccad\uc0c9\u00b7\ud669\uc0c9 )\uc5d0\ub2e4 \uc0c8\ub85c 4\uac1c(\ubd84\ud64d\uc0c9, \ubcf4\ub77c\uc0c9, \uc624\ub80c\uc9c0\uc0c9, \uccad\ub85d\uc0c9)\uac00 \ucd94\uac00\ub410\ub2e4. [\uc778\ub514\uc560\ub098 \uc758\uacfc\ub300\ud559\uc6d0 \uc81c\uacf5] \u00a0 \uacfc\ud559\uc790\ub4e4\uc774 \ub514\uc625\uc2dc\ub9ac\ubcf4\ud575\uc0b0(DNA)\ucc98\ub7fc \uc720\uc804 \uc815\ubcf4\ub97c \uc800\uc7a5\ud558\uace0 \uc804\ub2ec\ud560 \uc218 \uc788\ub294 \ubd84\uc790\uc2dc\uc2a4\ud15c\uc744 \ud569\uc131\ud574 \ub0c8\ub2e4. \uc774\ub294 \uc0c8\ub85c\uc6b4 \uc0dd\uba85\uccb4 \ud615\ud0dc\ub294 \uc544\ub2c8\uc9c0\ub9cc\u00a0DNA\uc5d0 \uae30\ubc18\ud55c \uc9c0\uad6c \uc0dd\uba85\uccb4\uc640\ub294 \uc804\ud600 \ub2e4\ub978 \uc678\uacc4 \uc0dd\uba85\uccb4\uac00\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1550,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1550","url_meta":{"origin":3304,"position":4},"title":"DNA tags used to image sugar-bearing proteins on cells","author":"biochemistry","date":"September 4, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 Methods for imaging sugars attached to proteins \u2014 the protein glycoforms \u2014 are of interest because glycoforms affect protein movement and localization in cells. A versatile approach is now reported that uses DNA as molecular identity tags. \u00a0 \u00a0 The attachment of sugar molecules to\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3018,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3018","url_meta":{"origin":3304,"position":5},"title":"\uadf9\uc800\uc628\uc804\uc790\ud604\ubbf8\uacbd\uc73c\ub85c \uad00\ucc30\ud55c RNA \uc911\ud569 \ud6a8\uc18c\uc758 \ubaa8\uc2b5","author":"biochemistry","date":"March 29, 2019","format":false,"excerpt":"\u00a0 \u00a0 2013\ub144 \uc0c8\ub85c\uc6b4 \uc804\uc790\ud0d0\uc9c0\uae30\uc758 \ub3c4\uc785\uc73c\ub85c \uadf9\uc800\uc628\uc804\uc790\ud604\ubbf8\uacbd(Cryo-EM)\uc774 \uc644\uc131\ub418\uba74\uc11c \uc0dd\ud654\ud559 \ubd84\uc57c\uc5d0\uc11c\ub294 \uadf8\uc57c\ub9d0\ub85c \u2018\uadf9\uc800\uc628\uc804\uc790\ud604\ubbf8\uacbd\u2019 \uc2dc\ub300\uac00 \uc5f4\ub838\ub2e4. \uc0dd\uccb4\ub9ac\ub4ec\uc744 \uc870\uc808\ud558\ub294 \ub2e8\ubc31\uc9c8\uc774\ub098, \uadc0\uc5d0\uc11c \uc555\ub825 \ubcc0\ud654\ub97c \ub290\uaef4 \uc77d\uace0 \ub4e3\uac8c \ub3c4\uc640\uc8fc\ub294 \uc13c\uc11c \ubd84\uc790, \uc9c0\uce74 \ubc14\uc774\ub7ec\uc2a4 \ub4f1\uc758 \uad6c\uc870\uac00 \uadf9\uc800\uc628\uc804\uc790\ud604\ubbf8\uacbd \uae30\uc220 \ub355\ubd84\uc5d0 \ubc1d\ud600\uc84c\ub2e4. \uc720\uba85\ud55c \uad6d\uc81c\ud559\uc220\uc9c0 \ud45c\uc9c0 \uc5ed\uc2dc \uc790\uc8fc \uadf9\uc800\uc628\uc804\uc790\ud604\ubbf8\uacbd\uc73c\ub85c \uad00\ucc30\ud55c \u25cb\u25cb\u25cb\uc758 \ubaa8\uc2b5\uc774 \uc790\uc8fc \uc7a5\uc2dd\ud558\uace0 \uc788\ub2e4. \uc774\ubc88 \uc8fc \ub124\uc774\ucc98\uc758 \ud45c\uc9c0\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_sharing_enabled":false,"jetpack_shortlink":"https:\/\/wp.me\/p9Xo1j-Ri","_links":{"self":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/3304","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3304"}],"version-history":[{"count":1,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/3304\/revisions"}],"predecessor-version":[{"id":3305,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/3304\/revisions\/3305"}],"wp:attachment":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3304"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3304"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3304"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}