<\/p>\n
![\"\uae38](\"https:\/\/img2.daumcdn.net\/thumb\/R430x0.q70\/?fname=https:\/\/t1.daumcdn.net\/news\/201904\/08\/yonhap\/20190408160429792oges.jpg\")
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\uc774\ubbf8\uc9c0 \ud06c\uac8c \ubcf4\uae30<\/a><\/p> <\/p>\n <\/p>\n \ucd5c\uadfc ‘\uad00\ubb38 \uc5b5\uc81c’ \uba74\uc5ed\uce58\ub8cc\ubc95\uc774 \uc8fc\ubaa9\ubc1b\ub294 \uc774\uc720\ub294, \uc885\uc804\uc5d0 \uce58\ub8cc\uac00 \ubd88\uac00\ub2a5\ud558\ub2e4\uace0 \uc5ec\uaca8\uc84c\ub358 \uc77c\ubd80 \uc554\uc5d0 \ud6a8\uacfc\ub97c \ubcf4\uae30 \ub54c\ubb38\uc774\ub2e4. \ud558\uc9c0\ub9cc \uc544\uc9c1 \uc774 \uce58\ub8cc\ubc95\uc5d0 \ubc18\uc751\uc744 \ubcf4\uc774\uc9c0 \uc54a\ub294 \uc554\uc774 \ud6e8\uc52c \ub354 \ub9ce\uace0, \ud6a8\uacfc\ub97c \ubcf4\ub354\ub77c\ub3c4 \uadf8 \uc774\uc720\ub97c \uc54c\uc9c0 \ubabb\ud558\ub294 \uacbd\uc6b0\uac00 \uc801\uc9c0 \uc54a\ub2e4.<\/p>\n \ubbf8\uad6d \uc0cc\ud504\ub780\uc2dc\uc2a4\ucf54 \uce98\ub9ac\ud3ec\ub2c8\uc544\ub300(UCSF) \uacfc\ud559\uc790\ub4e4\uc774 \ud604\uc7ac\uc758 \uba74\uc5ed\uce58\ub8cc\ubc95\uc774 \uc5ec\ub7ec \uc720\ud615\uc758 \uc554\uc5d0 \uc798 \ub4e3\uc9c0 \uc54a\ub294 \uc774\uc720\ub97c \uc124\uba85\ud560 \uc218 \uc788\ub294 \uc2e4\ub9c8\ub9ac\ub97c \ubc1c\uacac\ud588\ub2e4. \uc554\uc138\ud3ec\uac00 \uba74\uc5ed\uccb4\uacc4\uc758 \uacf5\uaca9\uc744 \ud68c\ud53c\ud558\ub294 \ub370 \uc774\uc6a9\ud558\ub294 \uc0c8\ub85c\uc6b4 \uba54\ucee4\ub2c8\uc998\uc744 \ucc3e\uc544\ub0b8 \uac83\uc774\ub2e4.<\/p>\n 5\uc77c(\ud604\uc9c0\uc2dc\uac04) \uc628\ub77c\uc778(www.eurekalert.org)\uc5d0 \ubc30\ud3ec\ub41c \ubcf4\ub3c4\uc790\ub8cc\uc5d0 \ub530\ub974\uba74 \uc774 \ub300\ud559\uc758 \ub85c\ubc84\ud2b8 \ube14\ub810\ub85c\ud06c \ube44\ub1e8\uae30\ud559 \uad50\uc218\ud300\uc774 \uc774\ub7f0 \ub0b4\uc6a9\uc758 \uc5f0\uad6c\ubcf4\uace0\uc11c\ub97c \uacfc\ud559 \uc800\ub110 ‘\uc140(Cell)’\uc5d0 \ubc1c\ud45c\ud588\ub2e4.<\/p>\n \ube14\ub810\ub85c\ud06c \uad50\uc218\ub294 “\ud751\uc0c9\uc885 \uac19\uc740 \uacbd\uc6b0 20% \ub0b4\uc9c0 30%\uc758 \ud658\uc790\ub9cc \uba74\uc5ed\uc5b5\uc81c \uce58\ub8cc\ub85c \ud6a8\uacfc\ub97c \ubcf4\ub294\ub370 \uc804\ub9bd\uc120\uc554 \ub4f1 \ub2e4\ub978 \uc720\ud615\uc758 \uc554\uc5d0\uc120 \ubc18\uc751\ub960\uc774 \ud55c \uc790\ub9bf\uc218\ub85c \ub5a8\uc5b4\uc9c4\ub2e4”\ub77c\uace0 \uba74\uc5ed\uce58\ub8cc\ubc95\uc758 \ud55c\uacc4\ub97c \uac15\uc870\ud588\ub2e4.<\/p>\n \uc545\uc131 \uc885\uc591 \uc138\ud3ec\uac00 \uc0dd\uc131\ud558\ub294 PD-L1 \ub2e8\ubc31\uc9c8\uc740 \uba74\uc5ed\uccb4\uacc4\ub85c\ubd80\ud130 \uc554\uc138\ud3ec\ub97c \uc228\uae30\ub294 ‘\ud22c\uba85 \ub9dd\ud1a0’ \uac19\uc740 \uae30\ub2a5\uc744 \ud55c\ub2e4.<\/p>\n \uac00\uc7a5 \uc131\uacf5\uc801\uc778 \uac83\uc73c\ub85c \ud3c9\uac00\ubc1b\ub294 \uba74\uc5ed\uce58\ub8cc\ubc95 \uc911 \uc77c\ubd80\ub294 \uc554\uc138\ud3ec \ud45c\uba74\uc758 PD-L1\uc774\ub098, T\uc138\ud3ec(\uba74\uc5ed\uc138\ud3ec) \ud45c\uba74\uc758 PD-1(Programmed cell death protein 1) \uc218\uc6a9\uccb4\ub97c \ubc29\ud574\ud558\ub294 \uac83\uc774\ub2e4. PD-L1\uacfc PD-1\uc774 \uacb0\ud569\ud574 \uc77c\uc73c\ud0a4\ub294 \uc0c1\ud638\uc791\uc6a9\uc744 \ucc28\ub2e8\ud558\uba74 \uc554\uc138\ud3ec\ub294 \uba74\uc5ed \ud68c\ud53c \ub2a5\ub825\uc744 \uc0c1\uc2e4\ud55c\ub2e4.<\/p>\n \uc77c\ubd80 \uc545\uc131 \uc885\uc591\uc740 PD-L1\uc744 \uc0dd\uc131\ud558\uc9c0 \uc54a\ub294 \ubc29\ubc95\uc73c\ub85c \uba74\uc5ed\uce58\ub8cc\uc5d0 \uc800\ud56d\ud558\ub294 \uac83\uc73c\ub85c \uc5ec\uaca8\uc84c\ub2e4. PD-L1\uc774 \uc0dd\uc131\ub418\uc9c0 \uc54a\uc73c\uba74 \uad00\ubb38 \uc5b5\uc81c \uce58\ub8cc\uc81c(checkpoint inhibitors)\uac00 \uc791\uc6a9\ud560 \ud45c\uc801\uc774 \uc0ac\ub77c\uc9c0\ub294 \uac83\uc774\ub2e4.<\/p>\n \uc774\ub807\uac8c PD-L1\uc744 \ubd84\ube44\ud558\uc9c0 \uc54a\ub294 \uc554\uc138\ud3ec\ub294 \ubbf8\uc9c0\uc758 \ub2e4\ub978 \uad00\ubb38 \ub2e8\ubc31\uc9c8(checkpoint proteins)\uc744 \uba74\uc5ed \ud68c\ud53c\uc5d0 \uc774\uc6a9\ud560 \uac83\uc73c\ub85c \ucd94\uc815\ub410\ub2e4. \uad00\ubb38 \uc5b5\uc81c \uce58\ub8cc\uc758 \ubc18\uc751\ub3c4\uac00 \ub0ae\uc740 \uc804\ub9bd\uc120\uc554 \ud658\uc790\uc758 \uc885\uc591\uc5d0\ub294 PD-L1\uc774 \uc544\uc8fc \ub0ae\uc740 \uc218\uc704\ub85c \uc788\uac70\ub098 \uc804\ud600 \uc5c6\ub2e4\ub294 \uac8c \ud655\uc778\ub418\uae30\ub3c4 \ud588\ub2e4.<\/p>\n \uc774\ubc88\uc5d0 \ube14\ub810\ub85c\ud06c \uad50\uc218\ud300\uc774 \ubc1c\uacac\ud55c \uac74 \uae30\uc874\uc758 \ud1b5\ub150\uc744 \uae68\ub294 \uac83\uc774\ub2e4.<\/p>\n \uc554 \uc885\uc591\uc774 PD-L1\uc744 \ub300\ub7c9 \uc0dd\uc131\ud558\uae34 \ud558\uc9c0\ub9cc, \uc554\uc138\ud3ec \ud45c\uba74\uc5d0 \ubd84\ube44\ud558\uc9c0 \uc54a\uc544 \ub9c8\uce58 PD-L1\uc744 \uc0dd\uc131\ud558\uc9c0 \uc54a\ub294 \uac83\ucc98\ub7fc \uc624\uc778\ud558\uac8c \ud55c\ub2e4\ub294 \uac83\uc774\ub2e4. \uc554\uc138\ud3ec\uac00 \uc0dd\uc131\ud55c PD-L1\uc740 \ub300\uc2e0, \ubd84\uc790 \uc6b4\ubc18\uccb4\uc778 \uc5e0\uc18c\uc880\uc5d0 \uc2e4\ub824 \ub9bc\ud504\uacc4\ub098 \ud608\ub958\ub97c \uac70\uccd0 \ub9bc\ud504\uc808\ub85c \ubcf4\ub0b4\uc9c0\ub294 \uac83\uc73c\ub85c \uad00\ucc30\ub410\ub2e4.<\/p>\n PD-L1\uc774 \uba40\ub9ac \ub5a8\uc5b4\uc9c4 \uba74\uc5ed\uccb4\uacc4\ub85c \uc6d0\uc815\uc744 \ub2e4\ub2c8\ub294 ‘\ud30c\uad34 \ubd84\uc790(molecular saboteurs)’ \uc5ed\ud560\uc744 \ud558\ub294 \uc148\uc774\ub2e4. \ub9bc\ud504\uc808\uc740 \ub9bc\ud504\uad6c\uc640 \ubc31\ud608\uad6c\uac00 \ubaa8\uc5ec \uc788\ub294 \uc8fc\uc694 \uba74\uc5ed\uae30\uad00\uc774\ub2e4. \ub610\ud55c \uc5d1\uc18c\uc880\uc5d0 \uc2e4\ub824 \uc62e\uaca8\uc9c0\ub294 PD-L1\uc740 \ud604\uc7ac \uc4f0\uc774\ub294 \uad00\ubb38 \uc5b5\uc81c\uc81c\uc5d0 \uc800\ud56d\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4.<\/p>\n \ube14\ub810\ub85c\ud06c \uad50\uc218\ub294 “PD-L1\uc744 \ub9bc\ud504\uc808\uc5d0 \ubcf4\ub0b4 \uba74\uc5ed\uccb4\uacc4\ub97c \uc6d0\uaca9 \uc5b5\uc81c\ud558\ub294 \uc774\ub7f0 \ubc29\uc2dd\uc740 \uc885\uc804\uc5d0 \uc54c\ub824\uc84c\ub358 \uac83\uacfc \uc644\uc804\ud788 \ub2e4\ub974\ub2e4”\ub77c\uace0 \uc9c0\uc801\ud588\ub2e4.<\/p>\n \uc5f0\uad6c\ud300\uc740 \ub2e8\ubc31\uc9c8\uc758 \uc804\uad6c\uccb4\uc778 ‘\uc804\ub839 RNA(mRNA)’\ub97c \uad00\ucc30\ud558\uba74\uc11c ‘PD-L1 \uc9d1\ub2e8 \uc774\ub3d9’\uc758 \uaf2c\ub9ac\ub97c \uc7a1\uc558\ub2e4. \uc554\uc138\ud3ec\uc5d0\uc11c \ub098\uc628 PD-L1\uc740 \ub9ce\uc9c0 \uc54a\uc740\ub370, \uc774 \ub2e8\ubc31\uc9c8 \ud615\uc131 \uc2e0\ud638\ub97c \uac00\uc9c4 mRNA\ub294 \ub9e4\uc6b0 \ub9ce\ub2e4\ub294 \uac8c \uc774\uc0c1\ud588\ub2e4.<\/p>\n \uc5f0\uad6c\ud300\uc740 \ub9bc\ud504\uc808\ub85c \uc62e\uaca8\uc9c0\ub294 PD-L1\uc774 \uba74\uc5ed \ud68c\ud53c \ub2a5\ub825\uae4c\uc9c0 \uc804\ub2ec\ud558\ub294\uc9c0\ub3c4 \uc2e4\ud5d8\ud588\ub2e4.<\/p>\n \uba3c\uc800 \uba74\uc5ed\uc5b5\uc81c\uc81c\uac00 \uc798 \ub4e3\uc9c0 \uc54a\ub294 \uc0dd\uc950\uc758 \uc804\ub9bd\uc120\uc554 \uc138\ud3ec\ub97c \uac74\uac15\ud55c \uc0dd\uc950\uc5d0 \uc774\uc2dd\ud588\ub354\ub2c8 \uc554\uc138\ud3ec\ub294 \ube60\ub974\uac8c \uc99d\uc2dd\ud588\ub2e4. \ud558\uc9c0\ub9cc \uc5d1\uc18c\uc880 \uc0dd\uc131 \uc720\uc804\uc790\ub97c \ub450 \uac1c \uc81c\uac70\ud55c \uc0dd\uc950\ub294, \uc720\uc804\uc801\uc73c\ub85c \ub3d9\uc77c\ud55c \uc0dd\uc950\uc5d0\uc11c \uc554\uc138\ud3ec\ub97c \uc774\uc2dd\ud574\ub3c4 \uc885\uc591\uc73c\ub85c \ucee4\uc9c0\uc9c0 \uc54a\uc558\ub2e4.<\/p>\n \uc544\uc6b8\ub7ec \uc5d1\uc18c\uc880 \uc0dd\uc131 \uc720\uc804\uc790\uac00 \uc788\uac74 \uc5c6\uac74 PD-L1\uc740 \ub9cc\ub4e4\uc5b4\uc9c0\uc9c0\ub9cc, \uc5d1\uc18c\uc880 \uc720\uc804\uc790\uac00 \uc5c6\ub294 \uc554\uc138\ud3ec\uc5d0\uc11c PD-L1\ub9c8\uc800 \ucc28\ub2e8\ud558\uba74 \uba74\uc5ed \uacf5\uaca9\uc744 \ud53c\ud558\uc9c0 \ubabb\ud55c\ub2e4\ub294 \uac83\ub3c4 \ubc1d\ud600\uc84c\ub2e4.<\/p>\n \uc5f0\uad6c\ud300\uc740 \uc774\ub7f0 \uc2e4\ud5d8\uacb0\uacfc\ub97c \uc885\ud569\ud574, \uc720\uc804\uc790 \ud3b8\uc9d1\uc73c\ub85c \uc554\uc138\ud3ec\uc758 \uc5d1\uc18c\uc880 \uc0dd\uc131\uc744 \ub9c9\uc73c\uba74, \uba74\uc5ed \uacf5\uaca9\uc744 \ud53c\ud558\ub294 \uc554 \uc885\uc591\uc5d0\ub9cc \uc9d1\uc911\ud574\uc11c \ud56d\uc554 \uba74\uc5ed \ubc18\uc751\uc744 \uc720\ub3c4\ud560 \uc218 \uc788\uc744 \uac70\ub77c\ub294 \uacb0\ub860\uc5d0 \ub3c4\ub2ec\ud588\ub2e4.<\/p>\n \uc5f0\uad6c\ud300\uc740 \uc5d1\uc18c\uc880 \uc720\uc804\uc790\ub97c \uc81c\uac70\ud55c \uc554\uc138\ud3ec\ub97c \uc815\uc0c1 \uc0dd\uc950\uc5d0 \uc774\uc2dd\ud558\uace0 90\uc77c\uc774 \uc9c0\ub09c \ub4a4 \uc5d1\uc18c\uc880 \uc720\uc804\uc790\uac00 \ub0a8\uc544 \uc788\ub294 \uc554\uc138\ud3ec\ub97c \uac19\uc740 \uc0dd\uc950\uc5d0 \uc774\uc2dd\ud588\ub2e4. \uadf8\ub7ac\ub354\ub2c8 \uc5e0\uc18c\uc880 \uc0dd\uc131 \ub2a5\ub825\uc774 \uc788\ub294 \uc554\uc138\ud3ec\ub3c4 \uc77c\ub2e8 \uc5d1\uc18c\uc880 \uc720\uc804\uc790\ub97c \uc81c\uac70\ud55c \uc554\uc138\ud3ec\uc5d0 \ub178\ucd9c\ub418\uba74 \uba74\uc5ed \ud68c\ud53c \ub2a5\ub825\uc744 \uc0c1\uc2e4\ud558\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4.<\/p>\n \ub610 \ud558\ub098\uc758 \ub180\ub77c\uc6b4 \uc0ac\uc2e4\uc740, \uc5d1\uc18c\uc880 \uc720\uc804\uc790\ub97c \uc81c\uac70\ud55c \uc554\uc138\ud3ec\uc640 \uc81c\uac70\ud558\uc9c0 \uc54a\uc740 \uc554\uc138\ud3ec\ub97c \uc0dd\uc950\uc758 \ud2b9\uc815 \uae30\uad00\uc5d0\uc11c \uc11c\ub85c \ubc18\ub300\ub418\ub294 \uc704\uce58\uc5d0 \uc774\uc2dd\ud55c \uc2e4\ud5d8\uc5d0\uc11c \ub4dc\ub7ec\ub0ac\ub2e4. \uc5d1\uc18c\uc880 \uc720\uc804\uc790\ub97c \uc81c\uac70\ud55c, \ub2e4\uc2dc \ub9d0\ud574 \uc5d1\uc18c\uc880\uc744 \uc0dd\uc131\ud558\uc9c0 \ubabb\ud558\ub294 \uc554\uc138\ud3ec\uac00 \uba74\uc5ed\uccb4\uacc4\ub97c \uc790\uadf9\ud574, \uba74\uc5ed \ud68c\ud53c \ub2a5\ub825\uc744 \uac16\ucdc4\uc744 \uc218 \uc788\ub294 \ubc18\ub300\ud3b8 \uc554\uc138\ud3ec\ub97c \uacf5\uaca9\ud558\uac8c \ud588\ub2e4.<\/p>\n \uc774\ub294 \uc5d1\uc18c\uc880\uc5d0\uc11c PD-L1\uc758 \ubd84\ube44\ub97c \uc77c\uc2dc\uc801\uc73c\ub85c \ucc28\ub2e8\ud574\ub3c4, \uccb4\ub0b4\uc5d0\uc11c \uc7a5\uae30\uac04\uc5d0 \uac78\uccd0 \uc554\uc138\ud3ec \uc131\uc7a5\uc744 \uc5b5\uc81c\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud558\ub294 \uac83\uc774\ub77c\uace0 \uc5f0\uad6c\ud300\uc740 \uc124\uba85\ud55c\ub2e4.<\/p>\n \ud658\uc790 \ubcf8\uc778\uc758 \uc554\uc138\ud3ec \uc720\uc804\uc790\ub97c \ud3b8\uc9d1\ud574 \uc7ac\uc774\uc2dd\ud558\uba74, \uc77c\uc885\uc758 ‘\uc885\uc591 \uc138\ud3ec \ubc31\uc2e0(tumor cell vaccine)’\ucc98\ub7fc \uba74\uc5ed \ud68c\ud53c \uc554\uc138\ud3ec\ub97c \uba74\uc5ed\uccb4\uacc4\ub85c \uacf5\uaca9\ud560 \uc218 \uc788\uc74c\uc744 \uc554\uc2dc\ud558\ub294 \uac83\uc774\uae30\ub3c4 \ud558\ub2e4.<\/p>\n \ud558\uc9c0\ub9cc \uc774\ubc88 \uc5f0\uad6c\uacb0\uacfc\ub294 \uba74\uc5ed\uce58\ub8cc\uc5d0 \ubc18\uc751\ud558\uc9c0 \uc54a\ub294 \ub9ce\uc740 \uc545\uc131 \uc885\uc591\uc744 \uc5b5\uc81c\ud560 \uac00\ub2a5\uc131\uc774 \uc788\ub294, \uc0c8\ub85c\uc6b4 \uba54\ucee4\ub2c8\uc998\uc744 \uaca8\uc6b0 \ud45c\uba74\ub9cc \uc0b4\uc9dd \ud565\uc544\ubcf8 \uc815\ub3c4\ub77c\ub294 \uac8c \uc5f0\uad6c\ud300\uc758 \ud310\ub2e8\uc774\ub2e4. \uc544\uc9c1 PD-L1\uc758 \uc791\uc6a9\uc5d0 \ub300\ud574 \uc54c\uc544\ub0bc \uac83\uc774 \ub9ce\ub2e4\ub294 \ub73b\uc774\ub2e4.<\/p>\n<\/section>\n<\/div>\n <\/p>\n <\/p>\n (\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n <\/p>\n <\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":"
![\uc774\ubbf8\uc9c0 \ud06c\uac8c \ubcf4\uae30<\/a><\/p>\uae38 \uc548\ub0b4 \ubc1b\ub4ef \ub530\ub77c\uac00\ub294 \uba74\uc5ed\uc138\ud3ec\ub4e4 [\uc0ac\uc774\uc5b8\uc2a4 \uc81c\uacf5]<\/figcaption><\/figure>\n <\/p>\n <\/p>\n\ucd5c\uadfc ‘\uad00\ubb38 \uc5b5\uc81c’ \uba74\uc5ed\uce58\ub8cc\ubc95\uc774 \uc8fc\ubaa9\ubc1b\ub294 \uc774\uc720\ub294, \uc885\uc804\uc5d0 \uce58\ub8cc\uac00 \ubd88\uac00\ub2a5\ud558\ub2e4\uace0 \uc5ec\uaca8\uc84c\ub358 \uc77c\ubd80 \uc554\uc5d0 \ud6a8\uacfc\ub97c \ubcf4\uae30 \ub54c\ubb38\uc774\ub2e4. \ud558\uc9c0\ub9cc \uc544\uc9c1 \uc774 \uce58\ub8cc\ubc95\uc5d0 \ubc18\uc751\uc744 \ubcf4\uc774\uc9c0 \uc54a\ub294 \uc554\uc774 \ud6e8\uc52c \ub354 \ub9ce\uace0, \ud6a8\uacfc\ub97c \ubcf4\ub354\ub77c\ub3c4 \uadf8 \uc774\uc720\ub97c \uc54c\uc9c0 \ubabb\ud558\ub294 \uacbd\uc6b0\uac00 \uc801\uc9c0 \uc54a\ub2e4.<\/p>\n\ubbf8\uad6d \uc0cc\ud504\ub780\uc2dc\uc2a4\ucf54 \uce98\ub9ac\ud3ec\ub2c8\uc544\ub300(UCSF) \uacfc\ud559\uc790\ub4e4\uc774 \ud604\uc7ac\uc758 \uba74\uc5ed\uce58\ub8cc\ubc95\uc774 \uc5ec\ub7ec \uc720\ud615\uc758 \uc554\uc5d0 \uc798 \ub4e3\uc9c0 \uc54a\ub294 \uc774\uc720\ub97c \uc124\uba85\ud560 \uc218 \uc788\ub294 \uc2e4\ub9c8\ub9ac\ub97c \ubc1c\uacac\ud588\ub2e4. \uc554\uc138\ud3ec\uac00 \uba74\uc5ed\uccb4\uacc4\uc758 \uacf5\uaca9\uc744 \ud68c\ud53c\ud558\ub294 \ub370 \uc774\uc6a9\ud558\ub294 \uc0c8\ub85c\uc6b4 \uba54\ucee4\ub2c8\uc998\uc744 \ucc3e\uc544\ub0b8 \uac83\uc774\ub2e4.<\/p>\n5\uc77c(\ud604\uc9c0\uc2dc\uac04) \uc628\ub77c\uc778(www.eurekalert.org)\uc5d0 \ubc30\ud3ec\ub41c \ubcf4\ub3c4\uc790\ub8cc\uc5d0 \ub530\ub974\uba74 \uc774 \ub300\ud559\uc758 \ub85c\ubc84\ud2b8 \ube14\ub810\ub85c\ud06c \ube44\ub1e8\uae30\ud559 \uad50\uc218\ud300\uc774 \uc774\ub7f0 \ub0b4\uc6a9\uc758 \uc5f0\uad6c\ubcf4\uace0\uc11c\ub97c \uacfc\ud559 \uc800\ub110 ‘\uc140(Cell)’\uc5d0 \ubc1c\ud45c\ud588\ub2e4.<\/p>\n\ube14\ub810\ub85c\ud06c \uad50\uc218\ub294 “\ud751\uc0c9\uc885 \uac19\uc740 \uacbd\uc6b0 20% \ub0b4\uc9c0 30%\uc758 \ud658\uc790\ub9cc \uba74\uc5ed\uc5b5\uc81c \uce58\ub8cc\ub85c \ud6a8\uacfc\ub97c \ubcf4\ub294\ub370 \uc804\ub9bd\uc120\uc554 \ub4f1 \ub2e4\ub978 \uc720\ud615\uc758 \uc554\uc5d0\uc120 \ubc18\uc751\ub960\uc774 \ud55c \uc790\ub9bf\uc218\ub85c \ub5a8\uc5b4\uc9c4\ub2e4”\ub77c\uace0 \uba74\uc5ed\uce58\ub8cc\ubc95\uc758 \ud55c\uacc4\ub97c \uac15\uc870\ud588\ub2e4.<\/p>\n\uc545\uc131 \uc885\uc591 \uc138\ud3ec\uac00 \uc0dd\uc131\ud558\ub294 PD-L1 \ub2e8\ubc31\uc9c8\uc740 \uba74\uc5ed\uccb4\uacc4\ub85c\ubd80\ud130 \uc554\uc138\ud3ec\ub97c \uc228\uae30\ub294 ‘\ud22c\uba85 \ub9dd\ud1a0’ \uac19\uc740 \uae30\ub2a5\uc744 \ud55c\ub2e4.<\/p>\n\uac00\uc7a5 \uc131\uacf5\uc801\uc778 \uac83\uc73c\ub85c \ud3c9\uac00\ubc1b\ub294 \uba74\uc5ed\uce58\ub8cc\ubc95 \uc911 \uc77c\ubd80\ub294 \uc554\uc138\ud3ec \ud45c\uba74\uc758 PD-L1\uc774\ub098, T\uc138\ud3ec(\uba74\uc5ed\uc138\ud3ec) \ud45c\uba74\uc758 PD-1(Programmed cell death protein 1) \uc218\uc6a9\uccb4\ub97c \ubc29\ud574\ud558\ub294 \uac83\uc774\ub2e4. PD-L1\uacfc PD-1\uc774 \uacb0\ud569\ud574 \uc77c\uc73c\ud0a4\ub294 \uc0c1\ud638\uc791\uc6a9\uc744 \ucc28\ub2e8\ud558\uba74 \uc554\uc138\ud3ec\ub294 \uba74\uc5ed \ud68c\ud53c \ub2a5\ub825\uc744 \uc0c1\uc2e4\ud55c\ub2e4.<\/p>\n\uc77c\ubd80 \uc545\uc131 \uc885\uc591\uc740 PD-L1\uc744 \uc0dd\uc131\ud558\uc9c0 \uc54a\ub294 \ubc29\ubc95\uc73c\ub85c \uba74\uc5ed\uce58\ub8cc\uc5d0 \uc800\ud56d\ud558\ub294 \uac83\uc73c\ub85c \uc5ec\uaca8\uc84c\ub2e4. PD-L1\uc774 \uc0dd\uc131\ub418\uc9c0 \uc54a\uc73c\uba74 \uad00\ubb38 \uc5b5\uc81c \uce58\ub8cc\uc81c(checkpoint inhibitors)\uac00 \uc791\uc6a9\ud560 \ud45c\uc801\uc774 \uc0ac\ub77c\uc9c0\ub294 \uac83\uc774\ub2e4.<\/p>\n\uc774\ub807\uac8c PD-L1\uc744 \ubd84\ube44\ud558\uc9c0 \uc54a\ub294 \uc554\uc138\ud3ec\ub294 \ubbf8\uc9c0\uc758 \ub2e4\ub978 \uad00\ubb38 \ub2e8\ubc31\uc9c8(checkpoint proteins)\uc744 \uba74\uc5ed \ud68c\ud53c\uc5d0 \uc774\uc6a9\ud560 \uac83\uc73c\ub85c \ucd94\uc815\ub410\ub2e4. \uad00\ubb38 \uc5b5\uc81c \uce58\ub8cc\uc758 \ubc18\uc751\ub3c4\uac00 \ub0ae\uc740 \uc804\ub9bd\uc120\uc554 \ud658\uc790\uc758 \uc885\uc591\uc5d0\ub294 PD-L1\uc774 \uc544\uc8fc \ub0ae\uc740 \uc218\uc704\ub85c \uc788\uac70\ub098 \uc804\ud600 \uc5c6\ub2e4\ub294 \uac8c \ud655\uc778\ub418\uae30\ub3c4 \ud588\ub2e4.<\/p>\n\uc774\ubc88\uc5d0 \ube14\ub810\ub85c\ud06c \uad50\uc218\ud300\uc774 \ubc1c\uacac\ud55c \uac74 \uae30\uc874\uc758 \ud1b5\ub150\uc744 \uae68\ub294 \uac83\uc774\ub2e4.<\/p>\n\uc554 \uc885\uc591\uc774 PD-L1\uc744 \ub300\ub7c9 \uc0dd\uc131\ud558\uae34 \ud558\uc9c0\ub9cc, \uc554\uc138\ud3ec \ud45c\uba74\uc5d0 \ubd84\ube44\ud558\uc9c0 \uc54a\uc544 \ub9c8\uce58 PD-L1\uc744 \uc0dd\uc131\ud558\uc9c0 \uc54a\ub294 \uac83\ucc98\ub7fc \uc624\uc778\ud558\uac8c \ud55c\ub2e4\ub294 \uac83\uc774\ub2e4. \uc554\uc138\ud3ec\uac00 \uc0dd\uc131\ud55c PD-L1\uc740 \ub300\uc2e0, \ubd84\uc790 \uc6b4\ubc18\uccb4\uc778 \uc5e0\uc18c\uc880\uc5d0 \uc2e4\ub824 \ub9bc\ud504\uacc4\ub098 \ud608\ub958\ub97c \uac70\uccd0 \ub9bc\ud504\uc808\ub85c \ubcf4\ub0b4\uc9c0\ub294 \uac83\uc73c\ub85c \uad00\ucc30\ub410\ub2e4.<\/p>\nPD-L1\uc774 \uba40\ub9ac \ub5a8\uc5b4\uc9c4 \uba74\uc5ed\uccb4\uacc4\ub85c \uc6d0\uc815\uc744 \ub2e4\ub2c8\ub294 ‘\ud30c\uad34 \ubd84\uc790(molecular saboteurs)’ \uc5ed\ud560\uc744 \ud558\ub294 \uc148\uc774\ub2e4. \ub9bc\ud504\uc808\uc740 \ub9bc\ud504\uad6c\uc640 \ubc31\ud608\uad6c\uac00 \ubaa8\uc5ec \uc788\ub294 \uc8fc\uc694 \uba74\uc5ed\uae30\uad00\uc774\ub2e4. \ub610\ud55c \uc5d1\uc18c\uc880\uc5d0 \uc2e4\ub824 \uc62e\uaca8\uc9c0\ub294 PD-L1\uc740 \ud604\uc7ac \uc4f0\uc774\ub294 \uad00\ubb38 \uc5b5\uc81c\uc81c\uc5d0 \uc800\ud56d\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4.<\/p>\n\ube14\ub810\ub85c\ud06c \uad50\uc218\ub294 “PD-L1\uc744 \ub9bc\ud504\uc808\uc5d0 \ubcf4\ub0b4 \uba74\uc5ed\uccb4\uacc4\ub97c \uc6d0\uaca9 \uc5b5\uc81c\ud558\ub294 \uc774\ub7f0 \ubc29\uc2dd\uc740 \uc885\uc804\uc5d0 \uc54c\ub824\uc84c\ub358 \uac83\uacfc \uc644\uc804\ud788 \ub2e4\ub974\ub2e4”\ub77c\uace0 \uc9c0\uc801\ud588\ub2e4.<\/p>\n\uc5f0\uad6c\ud300\uc740 \ub2e8\ubc31\uc9c8\uc758 \uc804\uad6c\uccb4\uc778 ‘\uc804\ub839 RNA(mRNA)’\ub97c \uad00\ucc30\ud558\uba74\uc11c ‘PD-L1 \uc9d1\ub2e8 \uc774\ub3d9’\uc758 \uaf2c\ub9ac\ub97c \uc7a1\uc558\ub2e4. \uc554\uc138\ud3ec\uc5d0\uc11c \ub098\uc628 PD-L1\uc740 \ub9ce\uc9c0 \uc54a\uc740\ub370, \uc774 \ub2e8\ubc31\uc9c8 \ud615\uc131 \uc2e0\ud638\ub97c \uac00\uc9c4 mRNA\ub294 \ub9e4\uc6b0 \ub9ce\ub2e4\ub294 \uac8c \uc774\uc0c1\ud588\ub2e4.<\/p>\n\uc5f0\uad6c\ud300\uc740 \ub9bc\ud504\uc808\ub85c \uc62e\uaca8\uc9c0\ub294 PD-L1\uc774 \uba74\uc5ed \ud68c\ud53c \ub2a5\ub825\uae4c\uc9c0 \uc804\ub2ec\ud558\ub294\uc9c0\ub3c4 \uc2e4\ud5d8\ud588\ub2e4.<\/p>\n\uba3c\uc800 \uba74\uc5ed\uc5b5\uc81c\uc81c\uac00 \uc798 \ub4e3\uc9c0 \uc54a\ub294 \uc0dd\uc950\uc758 \uc804\ub9bd\uc120\uc554 \uc138\ud3ec\ub97c \uac74\uac15\ud55c \uc0dd\uc950\uc5d0 \uc774\uc2dd\ud588\ub354\ub2c8 \uc554\uc138\ud3ec\ub294 \ube60\ub974\uac8c \uc99d\uc2dd\ud588\ub2e4. \ud558\uc9c0\ub9cc \uc5d1\uc18c\uc880 \uc0dd\uc131 \uc720\uc804\uc790\ub97c \ub450 \uac1c \uc81c\uac70\ud55c \uc0dd\uc950\ub294, \uc720\uc804\uc801\uc73c\ub85c \ub3d9\uc77c\ud55c \uc0dd\uc950\uc5d0\uc11c \uc554\uc138\ud3ec\ub97c \uc774\uc2dd\ud574\ub3c4 \uc885\uc591\uc73c\ub85c \ucee4\uc9c0\uc9c0 \uc54a\uc558\ub2e4.<\/p>\n\uc544\uc6b8\ub7ec \uc5d1\uc18c\uc880 \uc0dd\uc131 \uc720\uc804\uc790\uac00 \uc788\uac74 \uc5c6\uac74 PD-L1\uc740 \ub9cc\ub4e4\uc5b4\uc9c0\uc9c0\ub9cc, \uc5d1\uc18c\uc880 \uc720\uc804\uc790\uac00 \uc5c6\ub294 \uc554\uc138\ud3ec\uc5d0\uc11c PD-L1\ub9c8\uc800 \ucc28\ub2e8\ud558\uba74 \uba74\uc5ed \uacf5\uaca9\uc744 \ud53c\ud558\uc9c0 \ubabb\ud55c\ub2e4\ub294 \uac83\ub3c4 \ubc1d\ud600\uc84c\ub2e4.<\/p>\n\uc5f0\uad6c\ud300\uc740 \uc774\ub7f0 \uc2e4\ud5d8\uacb0\uacfc\ub97c \uc885\ud569\ud574, \uc720\uc804\uc790 \ud3b8\uc9d1\uc73c\ub85c \uc554\uc138\ud3ec\uc758 \uc5d1\uc18c\uc880 \uc0dd\uc131\uc744 \ub9c9\uc73c\uba74, \uba74\uc5ed \uacf5\uaca9\uc744 \ud53c\ud558\ub294 \uc554 \uc885\uc591\uc5d0\ub9cc \uc9d1\uc911\ud574\uc11c \ud56d\uc554 \uba74\uc5ed \ubc18\uc751\uc744 \uc720\ub3c4\ud560 \uc218 \uc788\uc744 \uac70\ub77c\ub294 \uacb0\ub860\uc5d0 \ub3c4\ub2ec\ud588\ub2e4.<\/p>\n\uc5f0\uad6c\ud300\uc740 \uc5d1\uc18c\uc880 \uc720\uc804\uc790\ub97c \uc81c\uac70\ud55c \uc554\uc138\ud3ec\ub97c \uc815\uc0c1 \uc0dd\uc950\uc5d0 \uc774\uc2dd\ud558\uace0 90\uc77c\uc774 \uc9c0\ub09c \ub4a4 \uc5d1\uc18c\uc880 \uc720\uc804\uc790\uac00 \ub0a8\uc544 \uc788\ub294 \uc554\uc138\ud3ec\ub97c \uac19\uc740 \uc0dd\uc950\uc5d0 \uc774\uc2dd\ud588\ub2e4. \uadf8\ub7ac\ub354\ub2c8 \uc5e0\uc18c\uc880 \uc0dd\uc131 \ub2a5\ub825\uc774 \uc788\ub294 \uc554\uc138\ud3ec\ub3c4 \uc77c\ub2e8 \uc5d1\uc18c\uc880 \uc720\uc804\uc790\ub97c \uc81c\uac70\ud55c \uc554\uc138\ud3ec\uc5d0 \ub178\ucd9c\ub418\uba74 \uba74\uc5ed \ud68c\ud53c \ub2a5\ub825\uc744 \uc0c1\uc2e4\ud558\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4.<\/p>\n\ub610 \ud558\ub098\uc758 \ub180\ub77c\uc6b4 \uc0ac\uc2e4\uc740, \uc5d1\uc18c\uc880 \uc720\uc804\uc790\ub97c \uc81c\uac70\ud55c \uc554\uc138\ud3ec\uc640 \uc81c\uac70\ud558\uc9c0 \uc54a\uc740 \uc554\uc138\ud3ec\ub97c \uc0dd\uc950\uc758 \ud2b9\uc815 \uae30\uad00\uc5d0\uc11c \uc11c\ub85c \ubc18\ub300\ub418\ub294 \uc704\uce58\uc5d0 \uc774\uc2dd\ud55c \uc2e4\ud5d8\uc5d0\uc11c \ub4dc\ub7ec\ub0ac\ub2e4. \uc5d1\uc18c\uc880 \uc720\uc804\uc790\ub97c \uc81c\uac70\ud55c, \ub2e4\uc2dc \ub9d0\ud574 \uc5d1\uc18c\uc880\uc744 \uc0dd\uc131\ud558\uc9c0 \ubabb\ud558\ub294 \uc554\uc138\ud3ec\uac00 \uba74\uc5ed\uccb4\uacc4\ub97c \uc790\uadf9\ud574, \uba74\uc5ed \ud68c\ud53c \ub2a5\ub825\uc744 \uac16\ucdc4\uc744 \uc218 \uc788\ub294 \ubc18\ub300\ud3b8 \uc554\uc138\ud3ec\ub97c \uacf5\uaca9\ud558\uac8c \ud588\ub2e4.<\/p>\n\uc774\ub294 \uc5d1\uc18c\uc880\uc5d0\uc11c PD-L1\uc758 \ubd84\ube44\ub97c \uc77c\uc2dc\uc801\uc73c\ub85c \ucc28\ub2e8\ud574\ub3c4, \uccb4\ub0b4\uc5d0\uc11c \uc7a5\uae30\uac04\uc5d0 \uac78\uccd0 \uc554\uc138\ud3ec \uc131\uc7a5\uc744 \uc5b5\uc81c\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud558\ub294 \uac83\uc774\ub77c\uace0 \uc5f0\uad6c\ud300\uc740 \uc124\uba85\ud55c\ub2e4.<\/p>\n\ud658\uc790 \ubcf8\uc778\uc758 \uc554\uc138\ud3ec \uc720\uc804\uc790\ub97c \ud3b8\uc9d1\ud574 \uc7ac\uc774\uc2dd\ud558\uba74, \uc77c\uc885\uc758 ‘\uc885\uc591 \uc138\ud3ec \ubc31\uc2e0(tumor cell vaccine)’\ucc98\ub7fc \uba74\uc5ed \ud68c\ud53c \uc554\uc138\ud3ec\ub97c \uba74\uc5ed\uccb4\uacc4\ub85c \uacf5\uaca9\ud560 \uc218 \uc788\uc74c\uc744 \uc554\uc2dc\ud558\ub294 \uac83\uc774\uae30\ub3c4 \ud558\ub2e4.<\/p>\n\ud558\uc9c0\ub9cc \uc774\ubc88 \uc5f0\uad6c\uacb0\uacfc\ub294 \uba74\uc5ed\uce58\ub8cc\uc5d0 \ubc18\uc751\ud558\uc9c0 \uc54a\ub294 \ub9ce\uc740 \uc545\uc131 \uc885\uc591\uc744 \uc5b5\uc81c\ud560 \uac00\ub2a5\uc131\uc774 \uc788\ub294, \uc0c8\ub85c\uc6b4 \uba54\ucee4\ub2c8\uc998\uc744 \uaca8\uc6b0 \ud45c\uba74\ub9cc \uc0b4\uc9dd \ud565\uc544\ubcf8 \uc815\ub3c4\ub77c\ub294 \uac8c \uc5f0\uad6c\ud300\uc758 \ud310\ub2e8\uc774\ub2e4. \uc544\uc9c1 PD-L1\uc758 \uc791\uc6a9\uc5d0 \ub300\ud574 \uc54c\uc544\ub0bc \uac83\uc774 \ub9ce\ub2e4\ub294 \ub73b\uc774\ub2e4.<\/p>\n<\/section>\n<\/div>\n <\/p>\n <\/p>\n(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n <\/p>\n <\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":" \ubbf8 UCSF \uc5f0\uad6c\uc9c4 \ubcf4\uace0\uc11c..\uad00\ubb38\uc5b5\uc81c \uba74\uc5ed\uce58\ub8cc ‘\ub3cc\ud30c\uad6c’ \uc774\ubbf8\uc9c0 \ud06c\uac8c \ubcf4\uae30\uae38 \uc548\ub0b4 \ubc1b\ub4ef \ub530\ub77c\uac00\ub294 \uba74\uc5ed\uc138\ud3ec\ub4e4 [\uc0ac\uc774\uc5b8\uc2a4 \uc81c\uacf5] \ucd5c\uadfc ‘\uad00\ubb38 \uc5b5\uc81c’ \uba74\uc5ed\uce58\ub8cc\ubc95\uc774 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