{"id":3235,"date":"2019-04-08T11:48:05","date_gmt":"2019-04-08T02:48:05","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=3235"},"modified":"2019-04-08T11:48:05","modified_gmt":"2019-04-08T02:48:05","slug":"%ed%82%a4-%ed%81%b4-%eb%95%8c-%ec%84%b1%ec%9e%a5%ed%8c%90%ec%97%90%ec%84%9c-%ec%9d%bc%ec%96%b4%eb%82%98%eb%8a%94-%ec%9d%bc","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3235","title":{"rendered":"\ud0a4 \ud074 \ub54c \uc131\uc7a5\ud310\uc5d0\uc11c \uc77c\uc5b4\ub098\ub294 \uc77c"},"content":{"rendered":"

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\uccad\uc18c\ub144 \uc2dc\uc808\uc744 \ub5a0\uc62c\ub9ac\uba74 \ud0a4\uac00 \uc791\uc544 \uc8fc\ub205 \ub4e0 \uc801\uc774 \ub9ce\uc544 \uc501\uc4f8\ud558\ub2e4. \ub2f9\uc2dc \uc911\uace0\uad50\ub294 \ud0a4 \uc21c\uc11c\ub85c \ubc88\ud638\ub97c \ub9e4\uacbc\ub294\ub370, \ud544\uc790\ub294 6\ub144\uc744 \ub2e4 \ud569\uccd0\ub3c4 \u201811\u2019\uc5d0 \ubd88\uacfc\ud588\ub2e4. \ud3c9\uade0 2\ubc88\uc774 \ucc44 \uc548 \ub410\ub2e4\ub294 \ub9d0\uc774\ub2e4. \ub2f9\uc2dc \ud55c \ubc18\uc5d0 60\uba85\uc778 \uac78 \uc0dd\uac01\ud558\uba74 \uc815\ub9d0 \uc791\uc558\ub2e4.<\/p>\n

\ud0a4\ub294 \ubf08 \uc131\uc7a5\ud310\uc758 \ud65c\ub3d9\uc5d0 \uc88c\uc6b0\ub418\uace0 \uc131\uc7a5\ud310\uc774 \ub2eb\ud788\uba74 \ub354 \uc774\uc0c1 \ud0a4\uac00 \ud06c\uc9c0 \uc54a\ub294\ub2e4. \uccad\uc18c\ub144 \uc2dc\uc808 \ud544\uc790\ub294 \uce5c\uad6c\ub4e4\uc5d0 \ube44\ud574 \uc131\uc7a5\ud310\uc774 \ub35c \ud65c\ubc1c\ud588\ub2e4\ub294 \ub9d0\uc774\ub2e4. \ub2e4\ud589\ud788 \uc131\uc7a5\ud310\uc774 \uc880 \ub2a6\uac8c \ub2eb\ud600 \ub300\ud559 \ub54c \uba87\u339d \ub354 \ud070 \ub355\ubd84\uc5d0 \ud0a4\ub294 \u2018\uc791\uc740 \ud3b8\u2019\uc5d0 \uc18d\ud55c\ub2e4.<\/p>\n

\uc131\uc7a5\ud310\uc740 \ubf08\ubab8\ud1b5\uacfc \ubf08\ub05d \uc0ac\uc774\uc5d0 \uc788\ub294 \uc587\uc740 \ud310 \ud615\ud0dc\uc758 \uc5f0\uace8\uc774\ub2e4. \uc131\uc7a5\ud638\ub974\ubaac\uc744 \ube44\ub86f\ud55c \uc5ec\ub7ec \uc0dd\uccb4\uc2e0\ud638\ub97c \uc9c1\uac04\uc811\uc73c\ub85c \ubc1b\uc544 \uc5f0\uace8\uc138\ud3ec\uac00 \ubd84\uc5f4\ud574 \ub450\uaebc\uc6cc\uc9c0\uace0 \ubf08\ubab8\ud1b5 \ucabd \uc5f0\uace8\uc774 \ubf08\uc870\uc9c1\uc73c\ub85c \uce58\ud658\ub418\uba74\uc11c \ubf08\ubab8\ud1b5\uc774 \uae38\uc5b4\uc838 \ud0a4\uac00 \ud070\ub2e4. \uadf8\ub7ec\ub098 \uc774 \uacfc\uc815\uc774 \uad6c\uccb4\uc801\uc73c\ub85c \uc5b4\ub5bb\uac8c \uc77c\uc5b4\ub098\ub294\uac00\uc5d0 \ub300\ud574\uc11c\ub294 \uc544\uc9c1 \uc544\ub294 \uac8c \ub9ce\uc9c0 \uc54a\ub2e4.<\/p>\n

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\uc67c\ucabd\uc740 \uc131\uc7a5\uae30 \ubf08\uc758 \uc77c\ubd80\ub85c \ubf08\ub05d\uacfc \ubf08\ubab8\ud1b5 \uc0ac\uc774\uc758 \ud30c\ub780 \ubd80\ubd84\uc774 \uc131\uc7a5\ud310(growth plate)\uc774\ub2e4. \uc624\ub978\ucabd\uc740 \uc131\uc7a5\ud310\uc744 \ud655\ub300\ud574 \ub3c4\uc2dd\ud654\ud55c \uadf8\ub9bc\uc73c\ub85c \uc138 \uac00\uc9c0 \uc5f0\uace8\uc138\ud3ec\uac00 \uce35\uc744 \uc774\ub8e8\uace0 \uc788\ub2e4. \ub9e8 \uc704 \ub465\uadfc \uc5f0\uace8\uc138\ud3ec\uce35(resting-zone chondrocytes)\uc5d0 \uc904\uae30\uc138\ud3ec(\ube68\uac04\uc0c9)\uac00 \uc874\uc7ac\ud55c\ub2e4. \uadf8\ub9ac\uace0 \ub465\uadfc \uc5f0\uace8\uc138\ud3ec\uc640 \ube44\ub300 \uc5f0\uace8\uc138\ud3ec \uc0ac\uc774\uc5d0 \uc2e0\ud638(Ihh\uc640 PTHrP)\ub97c \uc8fc\uace0\ubc1b\uc73c\uba70 \uc5f0\uace8\uc138\ud3ec\uc758 \uc99d\uc2dd\uc744 \ucd09\uc9c4\ud55c\ub2e4. \u24d2 \ub124\uc774\ucc98<\/span><\/span> <\/p>\n

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\ud559\uc220\uc9c0\u00a0\u2018\ub124\uc774\ucc98\u2019 3\uc6d4 14\uc77c\uc790\uc5d0\ub294 \uc131\uc7a5\ud310 \ud65c\ub3d9\uc758 \uc8fc\uc778\uacf5\uc778 \uc904\uae30\uc138\ud3ec\uc758 \uae30\uc6d0\uacfc \ubd84\ud654 \uba54\ucee4\ub2c8\uc998\uc744 \uaddc\uba85\ud55c \ub17c\ubb38\uc774 \uc2e4\ub838\ub2e4. \uc2a4\uc6e8\ub374 \uce74\ub864\ub9b0\uc2a4\uce74\uc5f0\uad6c\uc18c\ub97c \ube44\ub86f\ud55c \uc720\ub7fd\uc758 \uacf5\ub3d9\uc5f0\uad6c\ud300\uc740 \uc0dd\uc950\ub97c \ub300\uc0c1\uc73c\ub85c \uc138\ud3ec \ud558\ub098\ud558\ub098\ub97c \uad6c\ubd84\ud560 \uc218 \uc788\ub294 \ud615\uad11\uc5fc\uc0c9\ubc95\uc744 \uc368\uc11c \uc774 \ubbf8\uc2a4\ud130\ub9ac\ub97c \ud480\uc5c8\ub2e4.<\/p>\n

\uc131\uc7a5\ud310 \uc5f0\uace8\uc138\ud3ec\uc5d0 \ub300\ud574 \uc880 \ub354 \uc790\uc138\ud788 \uc0b4\ud3b4\ubcf4\uc790. \uc131\uc7a5\ud310 \uc5f0\uace8\uc138\ud3ec\ub294 3\uac1c \uce35\uc73c\ub85c \ub098\ub25c\ub2e4.<\/p>\n

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\uba3c\uc800\u00a0\u2018\ub465\uadfc \uc5f0\uace8\uc138\ud3ec\u2019\ub85c \ubf08\ub05d\uc5d0 \uba74\ud574\uc788\ub2e4. \ubcf4\ud1b5 \ubf08\uc758 \uc131\uc7a5\uc744 \ubb18\uc0ac\ud560 \ub54c \ubf08\ub05d\uc744 \uc704\uc5d0 \ubf08\ubab8\ud1b5\uc744 \uc544\ub798\uc5d0 \ubc30\uce58\ub418\uac8c \uadf8\ub9ac\ubbc0\ub85c \uc138 \uce35 \uac00\uc6b4\ub370 \uac00\uc7a5 \uc704\ub2e4.<\/p>\n

\uadf8 \uc544\ub798\u00a0\u2018\uc99d\uc2dd \uc5f0\uace8\uc138\ud3ec\u2019\uac00 \uc788\ub294\ub370 \ub0a9\uc791\ud55c \ubaa8\uc591\uc0c8\ub2e4. \uc774\ub984 \uadf8\ub300\ub85c \uc138\ud3ec\uac00 \ubd84\uc5f4\ud574 \uae38\uc774 \ubc29\ud5a5\uc73c\ub85c \uc99d\uc2dd\ud55c\ub2e4. \ubcbd\ub3cc\uc744 \uc313\uc544 \ub9cc\ub4e0 \uae30\ub465\ucc98\ub7fc \ubcf4\uc778\ub2e4.<\/p>\n

\ub9e8 \ubc11\uc740\u00a0\u2018\ube44\ub300 \uc5f0\uace8\uc138\ud3ec\u2019\uac00 \uc790\ub9ac\ud558\ub294\ub370 \ub9d0 \uadf8\ub300\ub85c \uc138\ud3ec\uac00 \ud06c\ub2e4. \uc138\ud3ec\ubd84\uc5f4\uc744 \ud558\uc9c0 \uc54a\uace0 \ub098\uc911\uc5d4 \uc624\ud788\ub824 \uc8fd\uace0 \uadf8 \ube48\uc790\ub9ac\ub97c \uace8\uc138\ud3ec\uac00 \ucc44\uc6cc \ubf08\ubab8\ud1b5\uc774 \uae38\uc5b4\uc9c0\ub294 \uac83\uc774\ub2e4.<\/p>\n

\uc138 \uac00\uc9c0 \uc5f0\uace8\uc138\ud3ec\ub294 \ud0dc\uc0dd\ubd80\ud130 \ub2e4\ub978 \uac8c \uc544\ub2c8\ub77c \ub465\uadfc \uc5f0\uace8\uc138\ud3ec\uac00 \uc99d\uc2dd \uc5f0\uace8\uc138\ud3ec\uac00 \ub418\uace0 \uc544\ub798\ucabd \uc99d\uc2dd \uc5f0\uace8\uc138\ud3ec\uac00 \ube44\ub300 \uc5f0\uace8\uc138\ud3ec\ub85c \ubc14\ub00c\ub294 \uac83\uc774\ub2e4.<\/p>\n

\uc5f0\uad6c\uc790\ub4e4\uc740 \uc138\ud3ec\uc758 \uc131\uaca9\uc744 \uc54c \uc218 \uc788\ub294 \ud45c\uc9c0\ubc95\uc744 \uc368\uc11c \ub465\uadfc \uc5f0\uace8\uc138\ud3ec\uc5d0\uc11c \uc904\uae30\uc138\ud3ec\ub97c \ucc3e\uc544\ub0b4\ub294 \ub370 \uc131\uacf5\ud588\ub2e4. \uc904\uae30\uc138\ud3ec\ub294 \ubbf8\ubd84\ud654\ub41c \uc138\ud3ec\ub85c \ud06c\uac8c \ub450 \uac00\uc9c0 \ubc29\uc2dd\uc73c\ub85c \ubd84\uc5f4\ud55c\ub2e4. \uba3c\uc800 \u2018\ube44\ub300\uce6d \uc138\ud3ec\ubd84\uc5f4\u2019\ub85c \uc904\uae30\uc138\ud3ec \ud558\ub098\uc640 \ubd84\ud654\ub420 \uc138\ud3ec\ub85c \ub098\ub25c\ub2e4. \ub530\ub77c\uc11c \uc904\uae30\uc138\ud3ec \uc218\ub294 \uadf8\ub300\ub85c\ub2e4(S \u2192 S + D). \ub2e4\uc74c\uc73c\ub85c \u2018\ub300\uce6d \uc138\ud3ec\ubd84\uc5f4\u2019\ub85c \uc904\uae30\uc138\ud3ec \ub450 \uac1c\ub85c \ub098\ub25c\ub2e4. \ub530\ub77c\uc11c \uc904\uae30\uc138\ud3ec \uc218\uac00 \ub298\uc5b4\ub09c\ub2e4(S \u2192 S + S).<\/p>\n

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\uc778\uac04\uc904\uae30\uc138\ud3ec \ud604\ubbf8\uacbd \uc0ac\uc9c4(Humanstemcell) \u24d2 \uc704\ud0a4\ud53c\ub514\uc544<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\uac13 \ud0dc\uc5b4\ub09c \uc0dd\uc950\uc758 \uc131\uc7a5\ud310 \ub465\uadfc \uc5f0\uace8\uc138\ud3ec\uc5d0\ub294 \uc904\uae30\uc138\ud3ec\uac00 \uba87 \uac1c \ub418\uc9c0 \uc54a\ub294\ub2e4. \ud0dc\uc544\uc77c \ub54c\ub294 \uc8fc\ub85c \ube44\ub300\uce6d \uc138\ud3ec\ubd84\uc5f4\uc744 \ud558\uae30 \ub54c\ubb38\uc774\ub2e4. \uadf8\ub7f0\ub370 \uc131\uc7a5\uae30\uc5d0 \ub4e4\uc5b4\uc11c\uc790 \ub300\uce6d \uc138\ud3ec\ubd84\uc5f4\uc774 \uc77c\uc5b4\ub098 \uc904\uae30\uc138\ud3ec \uc218\uac00 \ub298\uc5b4\ub0ac\ub2e4. \uadf8\ub9ac\uace0 \uc5ec\uae30\uc11c \ubd84\ud654\ub41c \uc99d\uc2dd \uc5f0\uace8\uc138\ud3ec\uac00 \uae38\uc774 \ubc29\ud5a5\uc73c\ub85c \ubd84\uc5f4\ud558\uba74\uc11c \uc544\ub7ab\ubd80\ubd84\uc740 \ube44\ub300 \uc5f0\uace8\uc138\ud3ec\uac00 \ub418\uace0 \uacb0\uad6d\uc740 \ubf08\ubab8\ud1b5\uc73c\ub85c \ubc14\ub00c\ub294 \uacfc\uc815\uc774 \ud65c\ubc1c\ud574\uc84c\ub2e4.<\/p>\n

\uc5f0\uad6c\uc790\ub4e4\uc740 \uc131\uc7a5\uae30\uc5d0 \ubf08\ub05d\uc5d0\uc11c \uc624\ub294 \uc2e0\ud638\uac00 \uc904\uae30\uc138\ud3ec\uc758\u00a0mTORC1 \uacbd\ub85c\ub97c \ud65c\uc131\ud654\ud574 \uc904\uae30\uc138\ud3ec\uac00 \ub300\uce6d \uc138\ud3ec\ubd84\uc5f4\uc744 \ud558\uac8c \uc131\uaca9\uc744 \ubc14\uafbc\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc54c\uc544\ub0c8\ub2e4. \ub610 \ube44\ub300 \uc5f0\uace8\uc138\ud3ec\uc640 \ub465\uadfc \uc5f0\uace8\uc138\ud3ec\uac00 \uc2e0\ud638\ub97c \uc8fc\uace0\ubc1b\uc544 \uc5f0\uace8\uc138\ud3ec\uc758 \uae38\uc774 \ubc29\ud5a5 \uc99d\uc2dd\uc744 \ucd09\uc9c4\ud558\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4. \uc774 \uc2e0\ud638\ub97c \ubc29\ud574\ud558\uba74 \uc5f0\uace8\uc138\ud3ec \uae30\ub465\uc774 \uc9e7\uc544\uc9c4\ub2e4.
\n\uacb0\uad6d \uc131\uc7a5\ud310\uc5d0 \uc788\ub294 \uc904\uae30\uc138\ud3ec\uac00 \ub300\uce6d \uc138\ud3ec\ubd84\uc5f4\uc744 \uc5bc\ub9c8\ub098 \ub9ce\uc774 \ud558\ub290\ub0d0\uc640 \uc138 \uac00\uc9c0 \uc720\ud615\uc758 \uc5f0\uace8\uc138\ud3ec \uc0ac\uc774\uc758 \uc2e0\ud638 \uad50\ud658\uc774 \uc5bc\ub9c8\ub098 \uc6d0\ud65c\ud788 \uc774\ub904\uc9c0\ub0d0\uc5d0 \ub530\ub77c \ubf08\ubab8\ud1b5\uc758 \uae38\uc774 \uc131\uc7a5\uc774 \uacb0\uc815\ub41c\ub2e4\ub294 \ub9d0\uc774\ub2e4. \uc774 \uacfc\uc815\uc5d0 \uad00\uc5ec\ud558\ub294 \ub2e4\uc591\ud55c \uc2e0\ud638 \ubd84\uc790\uc640 \uc880 \ub354 \uad6c\uccb4\uc801\uc778 \uba54\ucee4\ub2c8\uc998\uc774 \ubc1d\ud600\uc9c4\ub2e4\uba74 \uc131\uc7a5\ud310\uc744 \ud65c\uc131\ud654\uc2dc\ud0ac \uc218 \uc788\ub294 \ud6a8\uacfc\uc801\uc778 \ubc29\ubc95\uc774 \ub098\uc62c\uc9c0\ub3c4 \ubaa8\ub978\ub2e4.<\/p>\n

\ubb3c\ub860 \uc9c0\uae08\ub3c4 \uc131\uc7a5\ud638\ub974\ubaac\uc774 \uc788\uae30\ub294 \ud558\uc9c0\ub9cc \ud6a8\uacfc\uac00 \uadf8\ub9ac \ud06c\uc9c0 \uc54a\uace0 \uc7a5\uae30\uac04 \uc0ac\uc6a9\ud588\uc744 \ub54c \ubd80\uc791\uc6a9\uc5d0 \ub300\ud55c \uc6b0\ub824\ub3c4 \uc788\ub2e4. \ud6c4\uc18d \uc5f0\uad6c\uac00 \uc774\uc5b4\uc9c0\uba74 \uba38\uc9c0\uc54a\uc544 \ud6a8\uacfc\ub294 \ub354 \ud06c\uace0 \ubd80\uc791\uc6a9\uc740 \uc904\uc778 \u2018\ud0a4 \ud06c\ub294 \uce75\ud14c\uc77c(\uc131\uc7a5\ud638\ub974\ubaac \ud50c\ub7ec\uc2a4 \uc54c\ud30c)\u2019\uc774 \ub098\uc624\uc9c0 \uc54a\uc744\uae4c.<\/p>\n

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    \uccad\uc18c\ub144 \uc2dc\uc808\uc744 \ub5a0\uc62c\ub9ac\uba74 \ud0a4\uac00 \uc791\uc544 \uc8fc\ub205 \ub4e0 \uc801\uc774 \ub9ce\uc544 \uc501\uc4f8\ud558\ub2e4. \ub2f9\uc2dc \uc911\uace0\uad50\ub294 \ud0a4 \uc21c\uc11c\ub85c \ubc88\ud638\ub97c \ub9e4\uacbc\ub294\ub370, \ud544\uc790\ub294 6\ub144\uc744 \ub2e4 \ud569\uccd0\ub3c4 \u201811\u2019\uc5d0 \ubd88\uacfc\ud588\ub2e4. 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\ub0ae\uc9c0\ub9cc \uc7a0\uc7ac\ub825 \ubb34\uad81\ubb34\uc9c4 \u00a0 \u00a0 \u00a0 \ud398\uc774\uc2a4\ubd81\uc774 \uc0dd\uac01\ub9cc \ud558\uba74 \uace7\uc7a5 \ucef4\ud4e8\ud130\uc5d0 \uae00\uc790\uac00 \uc785\ub825\ub418\ub294 \ube44(\u975e)\uc0bd\uc785\ud615 \uc6e8\uc5b4\ub7ec\ube14(\ucc29\uc6a9\ud615) \uae30\uae30 \uac1c\ubc1c\uc5d0\uc11c \uc9c4\uc804\uc744 \uc774\ub918\ub2e4. \ube44\uc0bd\uc785\ud615\uc774\ub780 \uc678\uacfc\uc218\uc220\uc744 \ud1b5\ud574 \uc774\ub7f0 \uae30\uae30\ub97c \uccb4\ub0b4\uc5d0 \uc774\uc2dd\ud560 \ud544\uc694\uac00 \uc5c6\ub2e4\ub294 \ub73b\uc774\ub2e4. \ud398\uc774\uc2a4\ubd81\uc740 \uc9c0\ub09c 2017\ub144 \uac1c\ubc1c\uc790 \ucf58\ud37c\ub7f0\uc2a4 \u2018F8\u2019\uc5d0\uc11c \uc774 \uae30\uc220\uc5d0\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do 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