{"id":2904,"date":"2019-03-22T13:05:28","date_gmt":"2019-03-22T04:05:28","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=2904"},"modified":"2019-03-22T13:05:28","modified_gmt":"2019-03-22T04:05:28","slug":"%ec%9d%b8%ea%b0%84-%ec%84%b8%ed%8f%ac%ec%9d%98-dna-%eb%b3%b5%ea%b5%ac-%eb%af%b8%ec%8a%a4%ed%84%b0%eb%a6%ac-%ed%92%80%eb%a0%b8%eb%8b%a4","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2904","title":{"rendered":"\uc778\uac04 \uc138\ud3ec\uc758 ‘DNA \ubcf5\uad6c’ \ubbf8\uc2a4\ud130\ub9ac \ud480\ub838\ub2e4"},"content":{"rendered":"

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\ub3c5\uc77c \uc5f0\uad6c\uc9c4, ‘\ud788\uc2a4\ud1a4 \ucf54\ub4dc’ \uc791\ub3d9 \uc6d0\ub9ac \uaddc\uba85<\/p>\n

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\"\"<\/span><\/p>\n

BARD<\/span>\u00a01\ubd84\uc790\uc758\u00a0DNA<\/span>\u00a0\ubcf5\uad6c \uba54\ucee4\ub2c8\uc998 \uacb0\uc815 \uacfc\uc815[\ud5ec\ub984\ud640\uce20 \uccb8\ud2b8\ub8f8 \ubb8c\ud5e8 \uc81c\uacf5]<\/em><\/span><\/p>\n

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\uc138\ud3ec\uc758 \ub2e4\uc591\ud55c DNA<\/span>\u00a0\ubcf5\uad6c \uba54\ucee4\ub2c8\uc998 \uac00\uc6b4\ub370 \ud2b9\uc815 \uba54\ucee4\ub2c8\uc998\uc774 \uc120\ud0dd\ub418\ub294 \uae30\uc900\uacfc \uacfc\uc815\uc744 \ub3c5\uc77c\uc758 \ud658\uacbd\ubcf4\uac74 \uc5f0\uad6c\uae30\uad00\uc778 ‘\ud5ec\ub984\ud640\uce20 \uccb8\ud2b8\ub8f8 \ubb8c\ud5e8(Helmholtz<\/span>\u00a0Zentrum<\/span>Muenchen<\/span>)’ \uacfc\ud559\uc790\ub4e4\uc774 \ubc1d\ud600\ub0c8\ub2e4. \ubcf4\uace0\uc11c\ub294 \uacfc\ud559 \uc800\ub110 ‘\ub124\uc774\ucc98 \uc138\ud3ec \uc0dd\ubb3c\ud559(Nature<\/span>\u00a0Cell<\/span>Biology<\/span>)’\uc5d0 \uc2e4\ub838\ub2e4.<\/p>\n

27\uc77c(\ud604\uc9c0\uc2dc\uac04) \uc628\ub77c\uc778(www<\/span>.eurekalert<\/span>.org<\/span>)\uc5d0 \ubc30\ud3ec\ub41c \ubcf4\ub3c4\uc790\ub8cc\uc5d0 \ub530\ub974\uba74 \uc5f0\uad6c\ud300\uc740 \uc138\ud3ec\ud575\uc5d0\uc11c \uad00\ub828 \ub2e8\ubc31\uc9c8\uc744 \ucc3e\uc544\ub0b4\uae30 \uc704\ud574 \uc77c\uc885\uc758 ‘\ubd84\uc790 \ubbf8\ub07c’\ub97c \uac1c\ubc1c\ud588\ub2e4.<\/p>\n

\uc0dd\uba85\uccb4\uc758 \uc720\uc804 \uc815\ubcf4\ub294 \ubaa8\ub450\u00a0DNA<\/span>\uc758 \uae30\ucd08\uc801\uc778 \uc5fc\uae30\uc11c\uc5f4 \uc870\ud569\uc5d0 \ub4e4\uc5b4 \uc788\ub2e4. \ud558\uc9c0\ub9cc \ubaa8\ub4e0 \uc720\uc804\uc790\uac00 \uc77c\uc2dc\uc5d0 \ud65c\uc131\ud654\ub418\uc9c0 \uc54a\uc544\u00a0DNA<\/span>\u00a0\uc8fc\ubcc0\uc758 \ub2e4\ub978 \uc694\uc778\ub4e4\ub85c\ubd80\ud130 \uc601\ud5a5\uc744 \ubc1b\uae30\ub3c4 \ud55c\ub2e4. \uc5f0\uad6c\ud300\uc774 \ubbf8\ub07c\ub85c \uc4f4 \ud788\uc2a4\ud1a4(histone<\/span>) \ub2e8\ubc31\uc9c8\uc740 \uc774 \ubd80\ubd84\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4.<\/p>\n

\ud5ec\ub984\ud640\uce20 \uccb8\ud2b8\ub8f8 \ubb8c\ud5e8 \uc0b0\ud558\uc758 ‘\uae30\ub2a5\uc131 \ud6c4\uc0dd\uc720\uc804\ud559 \uc5f0\uad6c\uc18c(IFE<\/span>)’ \ubd80\uc18c\uc7a5\uc774\uc790 \ubcf4\uace0\uc11c\uc758 \uad50\uc2e0\uc800\uc790\uc778 \ud2f8 \ubc14\ub974\ud2b8\ucf00 \ubc15\uc0ac\ub294 “DNA<\/span>\ub97c \ub458\ub7ec\uc2f8\uace0 \uc788\ub294 \ud788\uc2a4\ud1a4\uc740 \uc720\uc804\uc790 \ubb3c\uc9c8\uc744 \ubb36\uc5b4\ub450\ub294 \uc5ed\ud560\ub3c4 \ud55c\ub2e4”\uba74\uc11c “\ud788\uc2a4\ud1a4\uc758 \ud654\ud559\uc801 \ubcc0\ud654\uc5d0 \ub530\ub77c\u00a0DNA<\/span>\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc774 \ub2ec\ub77c\uc9c0\uace0 \uc774\ub7f0 \uacfc\uc815\uc744 \ud1b5\ud574 \uc720\uc804\uc790 \ud65c\ub3d9\ub3c4 \uc81c\uc5b4\ub41c\ub2e4”\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n

\ubc14\ub974\ud2b8\ucf00 \ubc15\uc0ac\ud300\uc758 \uac00\uc7a5 \uc911\uc694\ud55c \uc5f0\uad6c\ubaa9\ud45c\ub294 \uc77c\uba85 ‘\ud788\uc2a4\ud1a4 \ucf54\ub4dc’\uc758 \uc791\ub3d9 \uc6d0\ub9ac\ub97c \ubc1d\ud600\ub0b4\ub294 \uac83\uc774\uc5c8\ub2e4.<\/p>\n

\uc5f0\uad6c\ud300\uc740 \uc9c0\uae08\uae4c\uc9c0 \uc54c\ub824\uc9c4 \ud788\uc2a4\ud1a4\uc758 \ud654\ud559\uc801 \ubcc0\ud615\ub4e4\uc744 \uc2dc\ud5d8\uad00\uc5d0 \uc7ac\uad6c\uc131\ud574, \uc138\ud3ec\ud575 \ucd94\ucd9c\ubb3c\uc5d0\uc11c \uc5b4\ub5a4 \ub2e8\ubc31\uc9c8\uc774 \uc5b4\ub5a4 \ubcc0\ud615\uc744 \uc120\ud0dd\ud574 \uacb0\ud569\ud558\ub294\uc9c0 \uad00\ucc30\ud588\ub2e4. \uc775\ud788 \uc54c\uace0 \uc788\ub294 \ud788\uc2a4\ud1a4 \ub2e8\ubc31\uc9c8\ub85c ‘\ubd84\uc790 \ubbf8\ub07c(molecular<\/span>\u00a0bait<\/span>)’\ub97c \ub9cc\ub4e4\uc5b4 \ud575\uc5d0 \ub358\uc838 \ub193\uace0 \ub09a\uc2dc\ub97c \ud55c \uac83\uacfc \ube44\uc2b7\ud558\ub2e4.<\/p>\n

\uc5f0\uad6c\ud300\uc740 \ucd5c\uadfc \uc0c8\ub85c \ud615\uc131\ub41c \uc138\ud3ec\uc9c8\ub9cc \uc120\ubcc4\uc801\uc73c\ub85c \uacb0\ud569\ud558\ub294 \ub2e8\ubc31\uc9c8\uc744 \ucc3e\ub294 \ub370\ub3c4 \uc774 \ubc29\ubc95\uc744 \uc37c\ub2e4. \uc2e0\uc0dd \uc138\ud3ec\uc9c8\uacfc \uae30\uc874 \uc138\ud3ec\uc9c8\uc744 \uad6c\ubd84\ud574 \ubd84\ud654\ud558\uace0,\u00a0DNA<\/span>\u00a0\ubcf5\uc81c\uc640 \ubcf5\uad6c\uc5d0\ub3c4 \uae30\ub2a5\uc801\uc73c\ub85c \uad00\uc5ec\ud558\ub294 \ub2e8\ubc31\uc9c8\uc744 \ud0d0\uc0c9\ud55c \uac83\uc774\uc5c8\ub2e4.<\/p>\n

\uadf8\ub7f0\ub370 \uc774\ubc88 \uc2e4\ud5d8\uc5d0\uc11c \uac78\ub824\ub4e0 \ubb3c\uace0\uae30\uac00 \uc5f0\uad6c\ud300\uc744 \ud765\ubd84\uc2dc\ucf30\ub2e4.<\/p>\n

\uad6c\uc870\uc801\uc73c\ub85c \uac19\uc740 ‘\uad70(\u7fa4)’\uc5d0 \uc18d\ud558\ub294 \ud6a8\uc18c \ubcf5\ud569\uccb4\ub4e4\uc774 \uc138\ud3ec\uc758\u00a0DNA<\/span>\u00a0\ubcf5\uad6c \uba54\ucee4\ub2c8\uc998 \uacb0\uc815\uc5d0 \uad00\uc5ec\ud558\uace0 \uc788\uc74c\uc744 \uc54c\uc544\ub0b8 \uac83\uc774\ub2e4. \uadf8 \uc720\uba85\ud55c\u00a0BRCA<\/span>1 \uc720\uc804\uc790\uc640 \uc5f0\uad00\ub41c \ud6a8\uc18c \ubcf5\ud569\uccb4\ub4e4\uc774\uc5c8\ub2e4.\u00a0BRCA<\/span>1\uc740 ‘Breast<\/span>\u00a0Cancer<\/span>\u00a01(\uc720\ubc29\uc554 1)’\uc758 \uc904\uc784\ub9d0\uc778\ub370 \uc720\ubc29\uc554 \uc704\ud5d8 \uc9c0\ud45c\ub85c \uc8fc\ubaa9\ubc1b\uace0 \uc788\ub2e4.<\/p>\n

\ubc14\ub974\ud2b8\ucf00 \ubc15\uc0ac\ub294 “BRCA<\/span>1 \uc720\uc804\uc790\uc5d0 \ub3cc\uc5f0\ubcc0\uc774 \ub9e4\uac1c\uccb4\uac00 \uc788\uc73c\uba74 \uc720\ubc29\uc554\uc774\ub098 \ub09c\uc18c\uc554 \ubc1c\ubcd1 \uc704\ud5d8\uc774 \ucee4\uc9c4\ub2e4.\u00a0DNA<\/span>\u00a0\uc190\uc0c1\uc744 \uc218\ub9ac\ud558\ub294 \uc2dc\uc2a4\ud15c\uc774 \uace0\uc7a5 \ub098, \uacb0\uacfc\uc801\uc73c\ub85c \ub354 \ud574\ub85c\uc6b4 \ub3cc\uc5f0\ubcc0\uc774\uac00 \ucd95\uc801\ub420 \uc218 \uc788\uae30 \ub54c\ubb38”\uc774\ub77c\uba74\uc11c “BRCA<\/span>1 \uc720\uc804\uc790\uc5d0 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac00\uc9c4 \uc554 \ud658\uc790\ub294 (\uc774\ub7f0 \uc554\uc5d0 \ud2b9\ud654\ub41c)\u00a0PARP<\/span>\uc5b5\uc81c\uc81c\ub85c \uce58\ub8cc\ubc1b\uc744 \uc218 \uc788\ub2e4”\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n

\ud55c\ud3b8 \uc774\ubc88 \ubcf4\uace0\uc11c\uc5d4 \uc601\uad6d \uc625\uc2a4\ud37c\ub4dc\ub300\uc758 \ub85c\uc2a4 \ucc44\ud504\uba3c \uad50\uc218\ud300\uacfc \ub374\ub9c8\ud06c \ucf54\ud39c\ud558\uac90\ub300\uc758 \uc544\ub2c8\uc544 \uadf8\ub85c\ud2b8 \uad50\uc218\ud300\uc758 \uc5f0\uad6c\uacb0\uacfc\ub3c4 \ubd80\ubd84\uc801\uc73c\ub85c \ubc18\uc601\ub410\ub2e4.<\/p>\n

\ubc14\ub974\ud2b8\ucf00 \ubc15\uc0ac\ub294 “\uc138 \uc5f0\uad6c\uc9c4\uc758 \ud611\ub825\uc5d0 \ud798\uc785\uc5b4\u00a0DNA<\/span>\u00a0\uc218\ub9ac \ub2e8\ubc31\uc9c8\uc758 \uc815\ud655\ud55c \uae30\ub2a5\uc744 \uc54c\uac8c \ub410\uace0,\u00a0BRCA<\/span>1 \ubcf5\ud569\uccb4\uc758 \uc138\ud3ec\uc9c8 \uc5f0\uacb0 \ubd80\uc704\ub97c \ucc38\uace0\ud574 \uc554 \ud658\uc790 \uce58\ub8cc\uc758 \ud45c\uc801 \uad6c\uc870\ub3c4 \ud655\uc778\ud588\ub2e4”\uba74\uc11c “\uc791\uc740 \ubd84\uc790\ub4e4(\ud788\uc2a4\ud1a4 \ub2e8\ubc31\uc9c8)\uc744 \ud65c\uc6a9\ud574\u00a0BRCA<\/span>1 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uac00\uc7a5\ud558\uba74, \uc774 \ub3cc\uc5f0\ubcc0\uc774\uac00 \uc5c6\ub294 \ud658\uc790\ub4e4\uc5d0\uac8c\ub3c4\u00a0PARP<\/span>\u00a0\uc5b5\uc81c\uc81c\ub97c \uc4f8 \uc218 \uc788\uc744 \uac83”\uc774\ub77c\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

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(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

    \ub3c5\uc77c \uc5f0\uad6c\uc9c4, ‘\ud788\uc2a4\ud1a4 \ucf54\ub4dc’ \uc791\ub3d9 \uc6d0\ub9ac \uaddc\uba85   BARD\u00a01\ubd84\uc790\uc758\u00a0DNA\u00a0\ubcf5\uad6c \uba54\ucee4\ub2c8\uc998 \uacb0\uc815 \uacfc\uc815[\ud5ec\ub984\ud640\uce20 \uccb8\ud2b8\ub8f8 \ubb8c\ud5e8 \uc81c\uacf5]   \uc138\ud3ec\uc758 \ub2e4\uc591\ud55c DNA\u00a0\ubcf5\uad6c \uba54\ucee4\ub2c8\uc998 \uac00\uc6b4\ub370 \ud2b9\uc815 \uba54\ucee4\ub2c8\uc998\uc774(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[33,29,30],"tags":[],"class_list":["post-2904","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","category-recent-science-news"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t