Gold \u2014 long presumed to be an inert metal \u2014 has been increasingly shaking this image over the past couple of decades, mostly through electrophilic behaviour. Now, a two-coordinate gold complex has been shown to exhibit nucleophilic reactivity, with the insertion of CO2<\/sub>into its polarized Au\u03b4\u2212<\/sup>\u2013Al\u03b4+<\/sup>\u00a0bond.<\/h5>\n <\/p>\n
<\/p>\n<\/div>\n<\/div>\n
\nFirst introduced in the 1970s by Dieter Seebach and Elias James Corey, the concept of umpolung is a cornerstone in organic chemistry. It describes the polarity inversion of an atom or a functional group, resulting in reactivity with an electronic flow inverse to that normally encountered. Now, using such an umpolung strategy, Jose Goicoechea, Simon Aldridge and co-workers have coaxed a gold complex into displaying nucleophilic reactivity in solution1<\/a><\/sup>.<\/p>\n <\/p>\n<\/div>\n
\nGold complexes are typically known to be extremely powerful electrophiles, in particular towards C\u2013C \u03c0-bonds, thereby promoting a number of useful catalytic transformations (such as the hydroamination of alkynes, alkenes, dienes and allenes). Comparatively, transition metal reactivity of gold (such as oxidative addition, migratory insertion, \u03b2-H elimination) has only started to be developed2<\/a><\/sup>, and nucleophilic behaviour was virtually unknown before this work. Ground-breaking studies by Martin Jansen and co-workers demonstrated in the 2000s the existence of anionic gold species (aurides) in liquid ammonia3<\/a><\/sup>, but no nucleophilic reactivity was reported. Conversely, gold was also found to behave as a Lewis basic metal in a few recently isolated complexes, via the formation of Au\u00b7\u00b7\u00b7H\u2012X hydrogen bonds4<\/a>,5<\/a><\/sup>\u00a0and Au\u2192Lewis acid interactions6<\/a><\/sup>. In addition, Daniela Bezuidenhout and co-workers reported in 2016 a tricoordinate T-shaped gold complex featuring two 1,2,3-triazol-5-ylidenes flanking a carbazolide moiety. Its gold centre was shown to be unusually electron-rich, as illustrated by protonation and alkylation reactions7<\/a><\/sup>.<\/p>\n <\/p>\n<\/div>\n
\nIn 2018, Goicoechea, Aldridge and colleagues showed8<\/a><\/sup>\u00a0that aluminium \u2014 a common Lewis acid used in many catalytic transformations \u2014 could be converted into a nucleophilic species through smart control of its coordination sphere with a tridentate (N,O,N) ligand (Fig.\u00a01<\/a>). Compound\u00a01<\/b>, which exists as a dimer, was made to react with a variety of organic and organometallic electrophiles, enabling the formation of unsupported aluminium\u2013carbon and aluminium\u2013heteroelement bonds.<\/p>\n <\/p>\n
\nFig. 1: Synthesis and reactivity of the gold complex 2.<\/b><\/figcaption>\n![\"Fig.](\"https:\/\/media.springernature.com\/m685\/springer-static\/image\/art%3A10.1038%2Fs41557-019-0223-z\/MediaObjects\/41557_2019_223_Fig1_HTML.png\")
<\/a><\/div>\n\n(i) Umpolung transfer from aluminium to gold. (ii) Insertion of CO2<\/sub>\u00a0into the polarized Au\u03b4\u2212<\/sup>\u2013Al\u03b4+<\/sup>\u00a0bond. Dipp, 2,6-i<\/i><\/sup>Pr2<\/sub>C6<\/sub>H3<\/sub>.<\/p>\n<\/div>\n<\/div>\nFull size image<\/a><\/div>\n<\/figure>\n<\/div>\n<\/div>\n\n <\/p>\n
<\/p>\n
What this group now shows is a spectacular next step: the aluminyl anion\u00a01<\/b>\u00a0readily binds to gold to form the linear two-coordinate complex\u00a02<\/b>\u00a0(Fig.\u00a01<\/a>)1<\/a><\/sup>. The presence of a bulky phosphine ligand at the gold centre (Pt<\/i><\/sup>Bu3<\/sub>) is required to prevent the formation of a dinuclear species. Complex\u00a02<\/b>, isolated as colourless crystals, is stable for weeks at room temperature. The Au\u2013Al bond length determined by X-ray diffraction analysis is, at 2.402(3) \u00c5, the shortest yet to be reported. As expected from the very large difference in electronegativity between Au (2.54) and Al (1.61), the Au\u2013Al bond is highly polarized Au\u03b4\u2212<\/sup>\u2013Al\u03b4+<\/sup>. The description of metal\u2013metal bonds involving gold is always a matter of debate, as the very high electronegativity tends to challenge the usual covalent and ionic bonding schemes. Yet calculations leave no doubt that the formation of\u00a02<\/b>\u00a0results from a significant transfer of electrons from Al to Au (by 1.56 electrons according to quantum theory of atoms in molecules (QTAIM) calculations) resulting in partial negative charge at Au (\u20130.82) and positive charge at Al (+0.56). Thus, the conversion of\u00a01<\/b>into\u00a02<\/b>\u00a0is accompanied by a transfer of umpolung. In other words, the electron-rich character of aluminium is transferred to gold.<\/p>\n <\/p>\n<\/div>\n
\nMost remarkable and illustrative of the Au\u03b4\u2212<\/sup>\u2013Al\u03b4+<\/sup>\u00a0bond polarity is the reaction of complex\u00a02<\/b>\u00a0with CO2<\/sub>\u00a0leading to complex\u00a03<\/b>. The gold atom binds to the central carbon atom, thus behaving as a nucleophile. In the meantime, the Lewis acidity of the aluminium centre is quenched by coordination of the oxygen atoms, resulting in a formal insertion of CO2<\/sub>into the Au\u2013Al bond of\u00a02<\/b>. The study also discloses similar reactivity of the Au\u2013Al complex with a carbodiimide,\u00a0i<\/i><\/sup>PrNCNi<\/i><\/sup>Pr, forming a similar Au\u2013Al insertion product to\u00a02<\/b>, featuring a Au\u2013C(Ni<\/i><\/sup>Pr)2<\/sub>\u2013Al moiety instead of the Au\u2013C(O)2<\/sub>\u2013Al one. Here, density functional theory calculations would be very welcome to shed light on the mechanism of this unorthodox reaction. Is the addition of the Au\u2013Al bond to CO2<\/sub>concerted? Which pole, the nucleophilic gold centre or the Lewis acidic aluminium centre drives the reaction, if any?<\/p>\n <\/p>\n<\/div>\n
\nThe bonding situation in\u00a02<\/b>\u00a0is reminiscent of that of existing gold\u2013boryl complexes, prepared from boryl anions9<\/a><\/sup>. In those, too, the gold centre is electron-rich and the gold\u2013boron bond is polarized as Au\u03b4\u2212<\/sup>\u2013B\u03b4+<\/sup>, although to a lesser extent. So far, no nucleophilic reactivity has been reported for those gold\u2013boryl complexes, but in light of the behaviour of the related gold\u2013aluminyl complex\u00a02<\/b>\u00a0their reactions with CO2<\/sub>, and heteroallenes in general, are definitely worth exploring.<\/p>\n <\/p>\n<\/div>\n
\nIn any case, the gold\u2013aluminyl complex\u00a02<\/b>\u00a0that has been prepared through an umpolung transfer strategy, and features a polarized Au\u03b4\u2013<\/sup>\u2013Al\u03b4+<\/sup>\u00a0bond, unambiguously displays nucleophilic reactivity at its gold centre. These findings emphasize the critical role of ancillary ligands in tuning the properties of both transition metals and main-group elements. Gold complexes have found tremendous interest as Lewis acids. Nucleophilic behaviour, as substantiated in this work, opens a new facet in gold chemistry. More generally, these findings underscore the importance of investigating new bonding situations and reactivity paths to advance our knowledge in molecular chemistry.<\/p>\n<\/div>\n\n<\/div>\n<\/section>\n <\/p>\n
<\/p>\n
(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n <\/p>\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
First introduced in the 1970s by Dieter Seebach and Elias James Corey, the concept of umpolung is a cornerstone in organic chemistry. It describes the polarity inversion of an atom or a functional group, resulting in reactivity with an electronic flow inverse to that normally encountered. Now, using such an umpolung strategy, Jose Goicoechea, Simon Aldridge and co-workers have coaxed a gold complex into displaying nucleophilic reactivity in solution1<\/a><\/sup>.<\/p>\n <\/p>\n<\/div>\n Gold complexes are typically known to be extremely powerful electrophiles, in particular towards C\u2013C \u03c0-bonds, thereby promoting a number of useful catalytic transformations (such as the hydroamination of alkynes, alkenes, dienes and allenes). Comparatively, transition metal reactivity of gold (such as oxidative addition, migratory insertion, \u03b2-H elimination) has only started to be developed2<\/a><\/sup>, and nucleophilic behaviour was virtually unknown before this work. Ground-breaking studies by Martin Jansen and co-workers demonstrated in the 2000s the existence of anionic gold species (aurides) in liquid ammonia3<\/a><\/sup>, but no nucleophilic reactivity was reported. Conversely, gold was also found to behave as a Lewis basic metal in a few recently isolated complexes, via the formation of Au\u00b7\u00b7\u00b7H\u2012X hydrogen bonds4<\/a>,5<\/a><\/sup>\u00a0and Au\u2192Lewis acid interactions6<\/a><\/sup>. In addition, Daniela Bezuidenhout and co-workers reported in 2016 a tricoordinate T-shaped gold complex featuring two 1,2,3-triazol-5-ylidenes flanking a carbazolide moiety. Its gold centre was shown to be unusually electron-rich, as illustrated by protonation and alkylation reactions7<\/a><\/sup>.<\/p>\n <\/p>\n<\/div>\n In 2018, Goicoechea, Aldridge and colleagues showed8<\/a><\/sup>\u00a0that aluminium \u2014 a common Lewis acid used in many catalytic transformations \u2014 could be converted into a nucleophilic species through smart control of its coordination sphere with a tridentate (N,O,N) ligand (Fig.\u00a01<\/a>). Compound\u00a01<\/b>, which exists as a dimer, was made to react with a variety of organic and organometallic electrophiles, enabling the formation of unsupported aluminium\u2013carbon and aluminium\u2013heteroelement bonds.<\/p>\n <\/p>\n (i) Umpolung transfer from aluminium to gold. (ii) Insertion of CO2<\/sub>\u00a0into the polarized Au\u03b4\u2212<\/sup>\u2013Al\u03b4+<\/sup>\u00a0bond. Dipp, 2,6-i<\/i><\/sup>Pr2<\/sub>C6<\/sub>H3<\/sub>.<\/p>\n<\/div>\n<\/div>\n <\/p>\n <\/p>\n What this group now shows is a spectacular next step: the aluminyl anion\u00a01<\/b>\u00a0readily binds to gold to form the linear two-coordinate complex\u00a02<\/b>\u00a0(Fig.\u00a01<\/a>)1<\/a><\/sup>. The presence of a bulky phosphine ligand at the gold centre (Pt<\/i><\/sup>Bu3<\/sub>) is required to prevent the formation of a dinuclear species. Complex\u00a02<\/b>, isolated as colourless crystals, is stable for weeks at room temperature. The Au\u2013Al bond length determined by X-ray diffraction analysis is, at 2.402(3) \u00c5, the shortest yet to be reported. As expected from the very large difference in electronegativity between Au (2.54) and Al (1.61), the Au\u2013Al bond is highly polarized Au\u03b4\u2212<\/sup>\u2013Al\u03b4+<\/sup>. The description of metal\u2013metal bonds involving gold is always a matter of debate, as the very high electronegativity tends to challenge the usual covalent and ionic bonding schemes. Yet calculations leave no doubt that the formation of\u00a02<\/b>\u00a0results from a significant transfer of electrons from Al to Au (by 1.56 electrons according to quantum theory of atoms in molecules (QTAIM) calculations) resulting in partial negative charge at Au (\u20130.82) and positive charge at Al (+0.56). Thus, the conversion of\u00a01<\/b>into\u00a02<\/b>\u00a0is accompanied by a transfer of umpolung. In other words, the electron-rich character of aluminium is transferred to gold.<\/p>\n <\/p>\n<\/div>\n Most remarkable and illustrative of the Au\u03b4\u2212<\/sup>\u2013Al\u03b4+<\/sup>\u00a0bond polarity is the reaction of complex\u00a02<\/b>\u00a0with CO2<\/sub>\u00a0leading to complex\u00a03<\/b>. The gold atom binds to the central carbon atom, thus behaving as a nucleophile. In the meantime, the Lewis acidity of the aluminium centre is quenched by coordination of the oxygen atoms, resulting in a formal insertion of CO2<\/sub>into the Au\u2013Al bond of\u00a02<\/b>. The study also discloses similar reactivity of the Au\u2013Al complex with a carbodiimide,\u00a0i<\/i><\/sup>PrNCNi<\/i><\/sup>Pr, forming a similar Au\u2013Al insertion product to\u00a02<\/b>, featuring a Au\u2013C(Ni<\/i><\/sup>Pr)2<\/sub>\u2013Al moiety instead of the Au\u2013C(O)2<\/sub>\u2013Al one. Here, density functional theory calculations would be very welcome to shed light on the mechanism of this unorthodox reaction. Is the addition of the Au\u2013Al bond to CO2<\/sub>concerted? Which pole, the nucleophilic gold centre or the Lewis acidic aluminium centre drives the reaction, if any?<\/p>\n <\/p>\n<\/div>\n The bonding situation in\u00a02<\/b>\u00a0is reminiscent of that of existing gold\u2013boryl complexes, prepared from boryl anions9<\/a><\/sup>. In those, too, the gold centre is electron-rich and the gold\u2013boron bond is polarized as Au\u03b4\u2212<\/sup>\u2013B\u03b4+<\/sup>, although to a lesser extent. So far, no nucleophilic reactivity has been reported for those gold\u2013boryl complexes, but in light of the behaviour of the related gold\u2013aluminyl complex\u00a02<\/b>\u00a0their reactions with CO2<\/sub>, and heteroallenes in general, are definitely worth exploring.<\/p>\n <\/p>\n<\/div>\n In any case, the gold\u2013aluminyl complex\u00a02<\/b>\u00a0that has been prepared through an umpolung transfer strategy, and features a polarized Au\u03b4\u2013<\/sup>\u2013Al\u03b4+<\/sup>\u00a0bond, unambiguously displays nucleophilic reactivity at its gold centre. These findings emphasize the critical role of ancillary ligands in tuning the properties of both transition metals and main-group elements. Gold complexes have found tremendous interest as Lewis acids. Nucleophilic behaviour, as substantiated in this work, opens a new facet in gold chemistry. More generally, these findings underscore the importance of investigating new bonding situations and reactivity paths to advance our knowledge in molecular chemistry.<\/p>\n<\/div>\n <\/p>\n <\/p>\n (\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n <\/p>\n <\/p>\n","protected":false},"excerpt":{"rendered":"<\/a><\/div>\n