{"id":2588,"date":"2019-01-29T16:27:58","date_gmt":"2019-01-29T07:27:58","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=2588"},"modified":"2019-01-29T16:27:58","modified_gmt":"2019-01-29T07:27:58","slug":"review-paper-current-and-future-influenza-vaccines","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2588","title":{"rendered":"Review Paper &#8211; Current and future influenza vaccines"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2 id=\"Abs1\" class=\"js-section-title section-title strong position-relative tighten-line-height background-gray-light pt20 pb6 pl0 pr20 standard-space-below small-space-above mq640-pt10 mq640-pb10 mq640-pl20 mq640-mt0 mq640-ml-20 mq640-mr-20 extend-left\">Abstract<\/h2>\n<div id=\"Abs1-content\" class=\"pl20 mq875-pl0 js-collapsible-section\">\n<p>Although antiviral drugs and vaccines have reduced the economic and healthcare burdens of influenza, influenza epidemics continue to take a toll. Over the past decade, research on influenza viruses has revealed a potential path to improvement. The clues have come from accumulated discoveries from basic and clinical studies. Now, virus surveillance allows researchers to monitor influenza virus epidemic trends and to accumulate virus sequences in public databases, which leads to better selection of candidate viruses for vaccines and early detection of drug-resistant viruses. Here we provide an overview of current vaccine options and describe efforts directed toward the development of next-generation vaccines. Finally, we propose a plan for the development of an optimal influenza vaccine.<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>(\uc6d0\ubb38: <a href=\"https:\/\/www.nature.com\/articles\/s41591-018-0340-z?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nm%2Frss%2Fcurrent+%28Nature+Medicine+-+Issue%29\">\uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; Abstract Although antiviral drugs and vaccines have reduced the economic and healthcare burdens of influenza, influenza epidemics continue to take a toll. Over<a href=\"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2588\" class=\"more-link\">(more&#8230;)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[33,29],"tags":[],"class_list":["post-2588","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":4969,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4969","url_meta":{"origin":2588,"position":0},"title":"Toward a universal flu vaccine","author":"biochemistry","date":"February 24, 2020","format":false,"excerpt":"\u00a0 \u00a0 Influenza virus infections pose a major public health threat, accounting for 3.5 million severe infections and more than 400,000 deaths globally each year (1). Most seasonal vaccines consist of inactivated influenza virus components, which induce antibody responses against immunodominant epitopes in the viral hemagglutinin (HA) and neuraminidase (NA)\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2977,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2977","url_meta":{"origin":2588,"position":1},"title":"Virus tricks the immune system into ignoring bacterial infections","author":"biochemistry","date":"March 29, 2019","format":false,"excerpt":"\u00a0 \u00a0 \u00a0 The finding could explain why the body tolerates some microbes \u2015 and lead to better treatments for chronic infections. \u00a0 \u00a0 Pseudomonas aeruginosa\u00a0bacteria can be responsible for persistent infections in wounds such as bedsores.\u00a0Credit: James Cavallini\/Science Photo Library \u00a0 \u00a0 A bacterium which is responsible for about\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4720,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4720","url_meta":{"origin":2588,"position":2},"title":"Measles erases immune \u2018memory\u2019 for other diseases &#038; How measles causes the body to \u2018forget\u2019 past infections","author":"biochemistry","date":"November 2, 2019","format":false,"excerpt":"\u00a0 Results from tests of unvaccinated children and monkeys come as measles cases spike around the world. \u00a0 \u00a0 Children with measles receive care in a hospital in the Philippines.Credit: Ezra Acayan\/Getty \u00a0 \u00a0 Measles infections in children can wipe out the immune system\u2019s memory of other illnesses such as\u00a0influenza,\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3809,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3809","url_meta":{"origin":2588,"position":3},"title":"The secret social lives of viruses","author":"biochemistry","date":"June 19, 2019","format":false,"excerpt":"\u00a0 \u00a0 Scientists are listening in on the ways viruses communicate and cooperate. Decoding what the microbes are saying could be a boon to human health. \u00a0 \u00a0 Illustration by Karol Banach \u00a0PDF version \u00a0 \u00a0 Geneticist Rotem Sorek could see that his bacteria were sick \u2014 so far, so\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4481,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4481","url_meta":{"origin":2588,"position":4},"title":"RNA therapies explained","author":"biochemistry","date":"October 18, 2019","format":false,"excerpt":"\u00a0 Treatments that target RNA or deliver it to cells fall into three broad categories, with hybrid approaches also emerging. \u00a0 \u00a0 Illustration of messenger RNA (red) produced from a DNA strand (purple).\u00a0Credit: Juan Gaertner\/SPL \u00a0 \u00a0 The conventional view of RNA casts the molecule in a supporting role \u2014\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":955,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=955","url_meta":{"origin":2588,"position":5},"title":"How cells imprison viruses in molecular cages","author":"biochemistry","date":"June 25, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 \u00a0 Vaccinia virus particles (pictured) can be immobilized \u2014 at least temporarily \u2014 by host cells. Credit: Dr Klaus Boller\/SPL How cells imprison viruses in molecular cages Corralled viruses escape by co-opting cellular proteins. \u00a0 A protein cage that cells deploy to slow the spread\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_sharing_enabled":false,"jetpack_shortlink":"https:\/\/wp.me\/p9Xo1j-FK","_links":{"self":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/2588","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2588"}],"version-history":[{"count":1,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/2588\/revisions"}],"predecessor-version":[{"id":2589,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/2588\/revisions\/2589"}],"wp:attachment":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}