{"id":2190,"date":"2018-11-30T12:12:05","date_gmt":"2018-11-30T03:12:05","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=2190"},"modified":"2018-11-30T12:12:05","modified_gmt":"2018-11-30T03:12:05","slug":"%eb%82%98%ec%9d%b4%eb%93%a4%eb%a9%b4-%ed%83%88%eb%aa%a8-%ec%83%9d%ea%b8%b0%eb%8a%94-%ec%9d%b4%ec%9c%a0-%ec%b0%be%ec%95%98%eb%8b%a4-%ec%84%b8%ed%8f%ac-%ec%86%8d-%ec%8b%a0%ed%98%b8%ec%a0%84%eb%8b%ac","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2190","title":{"rendered":"\ub098\uc774\ub4e4\uba74 \ud0c8\ubaa8 \uc0dd\uae30\ub294 \uc774\uc720 \ucc3e\uc558\ub2e4..”\uc138\ud3ec \uc18d \uc2e0\ud638\uc804\ub2ec \ubb38\uc81c \ud0d3”"},"content":{"rendered":"

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\"\ub098\uc774\ub4e4\uba74<\/p>\n

\uc774\ubbf8\uc9c0 \ud06c\uac8c \ubcf4\uae30<\/a><\/p>

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\ub098\uc774\ub4e4\uba74 \ud0c8\ubaa8 \uc0dd\uae30\ub294 \uc774\uc720 \ucc3e\uc558\ub2e4\u2026\u201c\uc138\ud3ec \uc18d \uc2e0\ud638\uc804\ub2ec \ubb38\uc81c \ud0d3\u201d<\/figcaption><\/figure>\n

\uacfc\ud559\uc790\ub4e4\uc774 \ub098\uc774\uac00 \ub4e4\uba74\uc11c \uc0dd\uae30\ub294 \ub178\ud654 \uad00\ub828 \ud0c8\ubaa8\ub97c \uce58\ub8cc\ud558\ub294 \uc57d\ubb3c\uc744 \ucc3e\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc0c8\ub85c\uc6b4 \uc758\ud559\uc801 \ubc1c\uacac\uc744 \ud574\ub0c8\ub2e4.<\/p>\n

\ubbf8\uad6d \ub274\uc695\uc758\ub300 \ub4f1 \uad6d\uc81c \uc5f0\uad6c\ud300\uc740 \uc2e4\ud5d8 \uc950\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc774 \uc5f0\uad6c\uc5d0\uc11c \uc190\uc0c1\ub41c \ud53c\ubd80\uc5d0\uc11c \ud138\uc774 \ub2e4\uc2dc \uc790\ub77c\uac8c \ud558\ub294 \ub370 \uc131\uacf5\ud588\uc73c\uba70 \uc774\ub294 \ubaa8\ubc1c \ub4f1 \ud138\uc774 \uc11c\uc11c\ud788 \ube60\uc9c0\ub294 \uacfc\uc815\uc744 \ub418\ub3cc\ub9ac\ub294 \ubc29\ubc95\uc744 \ubc1c\uacac\ud55c \uac83\uc774\ub77c\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

\uad6d\uc81c\ud559\uc220\uc9c0 \ub124\uc774\ucc98 \ucee4\ubba4\ub2c8\ucf00\uc774\uc158\uc2a4(Nature Communications) \ucd5c\uc2e0\ud638\uc5d0 \uc2e4\ub9b0 \uc5f0\uad6c\ub17c\ubb38\uc5d0 \ub530\ub974\uba74, \uc774\ub294 \ub1cc\uc758 \uc2e0\ud638\uc804\ub2ec \uacbd\ub85c\uc778 \u2018\uc18c\ub2c9\ud5e4\uc9c0\ud638\uadf8\u2019(SHH\u00b7Sonic hedgehog)\ub97c \ud65c\uc131\ud654\ud568\uc73c\ub85c\uc368 \uac00\ub2a5\ud588\ub2e4.<\/p>\n

SHH \uacbd\ub85c\ub294 \ud0dc\uc544\uc758 \ubaa8\ub0ad\uc774 \ud615\uc131\ud558\ub294 \ub3d9\uc548 \ub9e4\uc6b0 \ud65c\ubc1c\ud558\uac8c \uc2e0\ud638 \uad50\ud658\uc774 \uc774\ub904\uc9c0\uc9c0\ub9cc, \ub2e4\uce5c \ud53c\ubd80\ub098 \ub178\ud654\ud55c \ud53c\ubd80\uc5d0\uc11c\ub294 \uc2e0\ud638 \uad50\ud658\uc774 \uc81c\ub300\ub85c \uc774\ub904\uc9c0\uc9c0 \uc54a\ub294\ub2e4.<\/p>\n

\ud2b9\ud788 \uc774 \uc5f0\uad6c\ub294 \ud53c\ubd80\uc640 \ubaa8\ubc1c\uc758 \ud615\ud0dc\uc640 \uac15\ub3c4\ub97c \uc720\uc9c0\ud558\ub294 \ub370 \uac00\uc7a5 \ud070 \uc5ed\ud560\uc744 \ud558\ub294 \ub2e8\ubc31\uc9c8\uc778 \ucf5c\ub77c\uac90\uc744 \uc0dd\uc131\ud558\ub294 \uc12c\uc720\uc544\uc138\ud3ec\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd98 \uac83\uc774\ub2e4. \uc12c\uc720\uc544\uc138\ud3ec\ub294 \uce58\uc720\uc640 \uad00\ub828\ud55c \uc0dd\ubb3c\ud559\uc801 \uacfc\uc815 \uc911 \uc77c\ubd80\uc5d0 \uc9c1\uc811 \ub3c4\uc6c0\uc774 \ub41c\ub2e4\uace0 \uc54c\ub824\uc838 \uc5f0\uad6c\ud300\uc740 \uc774 \uc138\ud3ec\uc5d0 \uc8fc\ubaa9\ud588\ub2e4.<\/p>\n

\uc774\ubc88 \uc5f0\uad6c\uc5d0\uc11c \uc5f0\uad6c\ud300\uc740 SHH \uacbd\ub85c\ub97c \ud65c\uc131\ud654\ud568\uc73c\ub85c\uc368 \uc12c\uc720\uc544\uc138\ud3ec\ub4e4 \uc0ac\uc774\uc5d0 \u2018\uc2e0\ud638 \uad50\ud658\u2019\uc774 \uc6d0\ud65c\ud558\uac8c \uc774\ub904\uc9c0\uac8c \ud588\ub2e4. \uadf8\ub7ec\uc790 \uc950\ub4e4\uc758 \uc190\uc0c1\ub41c \ud53c\ubd80\uc5d0\uc11c 4\uc8fc \uc548\uc5d0 \ud138\uc774 \ub2e4\uc2dc \uc790\ub77c\uae30 \uc2dc\uc791\ud55c \uac83\uc774\ub2e4. \ubaa8\uadfc(\ud138 \ubfcc\ub9ac)\uacfc \ubaa8\uac04(\ud138 \uc904\uae30)\uc758 \uad6c\uc870\ub294 9\uc8fc \ub4a4\ubd80\ud130 \ub098\ud0c0\ub098\uae30 \uc2dc\uc791\ud588\ub2e4.<\/p>\n

\uc9c0\uae08\uae4c\uc9c0 \uacfc\ud559\uc790\ub4e4\uc740 \ud53c\ubd80\uc5d0 \ud749\ud130\uac00 \uc0dd\uae30\uace0 \ucf5c\ub77c\uac90\uc774 \ucd95\uc801\ub418\ub294 \uac83\uc774 \ubaa8\ubc1c\uc758 \uc7ac\uc131\uc7a5\uc744 \ub9c9\ub294 \uc774\uc720\ub77c\uace0 \uc0dd\uac01\ud588\ub2e4. \ud558\uc9c0\ub9cc \uc774\ubc88 \uc99d\uac70\ub294 \ubaa8\ubc1c \uc7ac\uc131\uc7a5\uc744 \ub2e4\uc2dc \uc870\uba85\ud558\uac8c \ub418\ub294 \uac83\uc774\ub2e4.<\/p>\n

\uc774\uc5d0 \ub300\ud574 \uc5f0\uad6c\ub97c \uc8fc\ub3c4\ud55c \uc774\ud1a0 \ub9c8\uc720\ubbf8 \ub274\uc695\uc758\ub300 \ud53c\ubd80\uacfc \ubd80\uad50\uc218\ub294 \u201c\uc774\uc81c \uc6b0\ub9ac\ub294 \ub178\ud654\uc640 \uad00\ub828\ud55c \ud0c8\ubaa8\uac00 \uc2e0\ud638\uc804\ub2ec \ubb38\uc81c\uc784\uc744 \uc54c\uac8c \ub410\ub2e4\u201d\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\uc774\ubc88 \uacb0\uacfc\ub294 \uc190\uc0c1\ub41c \ud53c\ubd80\uc758 \ud68c\ubcf5\uc744 \ub3c4\uc6b8 \ubfd0\ub9cc \uc544\ub2c8\ub77c \ub178\ud654\ub41c \ub450\ud53c\uc5d0\uc11c \ub2e4\uc2dc \ubaa8\ubc1c\uc774 \uc790\ub77c\uac8c \ud560 \uc218 \uc788\ub294 \uc99d\uac70\uac00 \ub418\uae30\ub3c4 \ud55c\ub2e4. \uc774\ub7f0 \uc99d\uac70\ub294 \uc55e\uc73c\ub85c \ubaa8\ubc1c \uc131\uc7a5\uc744 \ucd09\uc9c4\ud558\ub294 \ub354 \uc88b\uc740 \uc57d\ubb3c\uc744 \ucc3e\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uc218 \uc788\ub2e4\uace0 \uc5f0\uad6c\ud300\uc740 \ub9d0\ud588\ub2e4.<\/p>\n

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\n

<\/p>\n

\uc774\ubbf8\uc9c0 \ud06c\uac8c \ubcf4\uae30<\/a><\/p>\n<\/figure>\n

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\uae30\uc874 \uc5ec\ub7ec \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74, SHH \uacbd\ub85c\uc758 \ud65c\uc131\ud654\ub294 \uc885\uc885 \uc885\uc591 \ubc1c\uc0dd \uc704\ud5d8\uc744 \ub192\uc774\ub294 \ubd80\uc791\uc6a9\uc774 \uc788\ub2e4. \uc774\uc5d0 \ub530\ub77c \uc5f0\uad6c\ud300\uc740 \uc774\ub7f0 \uc704\ud5d8\uc744 \ud53c\ud558\uace0\uc790 \ubaa8\ub0ad \ubfcc\ub9ac \ubd80\ubd84\uc5d0 \uc788\ub294 \ubaa8\uc720\ub450(DP\u00b7dermal papillae)\uc758 \uc12c\uc720\uc544\uc138\ud3ec\ub9cc\uc744 \ud65c\uc131\ud654\ud558\ub294 \ub370 \uc131\uacf5\ud588\ub2e4.<\/p>\n

\uc5f0\uad6c\ud300\uc758 \ubaa9\ud45c\ub294 \ubaa8\ubc1c \uc7ac\uc131\uc7a5\uc744 \ucd09\uc9c4\ud558\ub294 \uc57d\ubb3c\uc744 \ucc3e\ub294 \uac83\uc774\ub2e4. \ud604\uc7ac \ud5c8\uac00\ub41c \uc57d\ubb3c\ub4e4\uc740 \ubd80\uc791\uc6a9\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n

\ucc98\ubc29\uc804 \uc5c6\uc774 \uad6c\ub9e4\ud560 \uc218 \uc788\ub294 \ubbf8\ub179\uc2dc\ub51c\uc740 \ub450\ud53c\ub85c \uac00\ub294 \ud608\ub958\ub7c9\uc744 \ub192\uc5ec \ubaa8\ub0ad\uc5d0 \uc601\uc591\uc744 \uacf5\uae09\ud55c\ub2e4. \uc774\ub294 \uc57d 3\ubd84\uc758 2\uc758 \ub0a8\ub140 \ud658\uc790\uc5d0\uac8c \ub3c4\uc6c0\uc774 \ub418\uace0 \uc788\uc9c0\ub9cc, \uc2ec\uc7a5\ubc15\ub3d9\uc744 \ube60\ub974\uac8c \ud558\uace0 \ubc1c\uc744 \ubd93\uac8c \ud558\uba70 \ubcf5\ud1b5\uc744 \uc77c\uc73c\ud0a4\ub294 \ub4f1 \ubd80\uc791\uc6a9\uc744 \uc720\ubc1c\ud55c\ub2e4.<\/p>\n

\ucc98\ubc29\uc804\uc774 \uc788\uc5b4\uc57c \uc0b4 \uc218 \uc788\ub294 \ud53c\ub098\uc2a4\ud14c\ub77c\uc774\ub4dc\ub294 \ub0a8\uc131\uc6a9\uc73c\ub85c, \ub0a8\uc131 \ud638\ub974\ubaac\uc778 \ud14c\uc2a4\ud1a0\uc2a4\ud14c\ub860\uc774 \ud0c8\ubaa8\ub97c \uc720\ubc1c\ud558\ub294 \ub2e4\uc774\ud558\uc774\ub4dc\ub85c\ud14c\uc2a4\ud1a0\uc2a4\ud14c\ub860(DHT)\uc73c\ub85c \ubc14\ub00c\ub294 \uac83\uc744 \uc5b5\uc81c\ud55c\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74, \uc774 \uc57d\ubb3c\uc740 \ucd5c\ub300 80%\uc758 \ub0a8\uc131\uc5d0\uac8c\uc11c \ubaa8\ubc1c \uc131\uc7a5\uc744 \ucd09\uc9c4\ud558\uc9c0\ub9cc, 60\uba85 \uc911 1\uba85\uc740 \ubc1c\uae30\ubd80\uc804\uc744 \uacbd\ud5d8\ud558\uba70 \uc774\ub7f0 \uc704\ud5d8\uc740 \uc57d\ubb3c\uc744 \ub354 \uc624\ub798 \ubcf5\uc6a9\ud560\uc218\ub85d \uc99d\uac00\ud55c\ub2e4.<\/p>\n

\ud55c\ud3b8 \ubbf8\uad6d \ud53c\ubd80\uacfc\ud559\ud68c(AAD\u00b7American Academy of Dermatology)\uc5d0 \ub530\ub974\uba74, \ub0a8\uc131\uc758 \uc57d 25%\ub294 25\uc138 \uc774\uc804\uc5d0 \ud0c8\ubaa8\uac00 \uc2dc\uc791\ub418\uba70, \uc5ec\uc131\uc740 40\uc138\uae4c\uc9c0 40% \uc815\ub3c4\uac00 \ud0c8\ubaa8\ub97c \uacbd\ud5d8\ud55c\ub2e4.<\/p>\n

 <\/p>\n

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\uc0ac\uc9c4=123rf(\uc704), \ub124\uc774\ucc98 \ucee4\ubba4\ub2c8\ucf00\uc774\uc158\uc2a4<\/p>\n

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\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~<\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

    \uc774\ubbf8\uc9c0 \ud06c\uac8c \ubcf4\uae30    \ub098\uc774\ub4e4\uba74 \ud0c8\ubaa8 \uc0dd\uae30\ub294 \uc774\uc720 \ucc3e\uc558\ub2e4\u2026\u201c\uc138\ud3ec \uc18d \uc2e0\ud638\uc804\ub2ec \ubb38\uc81c \ud0d3\u201d \uacfc\ud559\uc790\ub4e4\uc774 \ub098\uc774\uac00 \ub4e4\uba74\uc11c \uc0dd\uae30\ub294 \ub178\ud654 \uad00\ub828 \ud0c8\ubaa8\ub97c \uce58\ub8cc\ud558\ub294 \uc57d\ubb3c\uc744 \ucc3e\ub294(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[33,29,30],"tags":[],"class_list":["post-2190","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","category-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":2418,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2418","url_meta":{"origin":2190,"position":0},"title":"\uc2dd\ubb3c\uc774 \uc911\ub825\uc5d0 \uc608\ubbfc\ud55c \uc774\uc720","author":"biochemistry","date":"January 4, 2019","format":false,"excerpt":"\u00a0 \u00a0 \u00a0 [\uc694\uc57d] \uc2dd\ubb3c\uc740 \uc5b4\ub5a4 \uc0c1\ud669\uc5d0\uc11c\ub3c4 \ud558\ub298\uc744 \ud5a5\ud574 \ub611\ubc14\ub85c \uc790\ub780\ub2e4. \uc911\ub825\uc744 \uac10\uc9c0\ud558\uae30 \ub54c\ubb38\uc73c\ub85c \uc54c\ub824\uc838 \uc788\ub294\ub370 \ud504\ub791\uc2a4 \uad6d\ub9bd\uacfc\ud559\uc5f0\uad6c\uc6d0 \uc5f0\uad6c\uc9c4\uc740 \uc2dd\ubb3c\uc774 \uc774\ud1a0\ub85d \uc911\ub825\uc5d0 \uc608\ubbfc\ud55c \uc774\uc720\ub97c \ubc1d\ud614\ub2e4. \uc2dd\ubb3c \uc138\ud3ec \ub0b4 \uc804\ubd84 \uc785\uc790\uac00 \ub3c5\ub9bd\uc801\uc73c\ub85c \uc694\ub3d9\uce58\uba70 \ub9c8\uce58 \uc561\uccb4\ucc98\ub7fc \ud750\ub974\uba70 \uc131\uc7a5\uc758 \uae30\uc900\uc810\uc744 \uc81c\uacf5\ud558\ub294 \uac83\uc73c\ub85c \ubd84\uc11d\ub410\ub2e4. (2018. 05) \u00a0 \uad6c\ubd80\ub824\uc9c4 \ubc00 \uc78e \ub0b4\ubd80\ub97c \ub4e4\uc5ec\ub2e4\ubcf4\uba74 \uc804\ubd84 \uc138\ud3ec\uc758\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxODA1MDdfMjIg\/MDAxNTI1Njg0MTM0ODUw.MAgXN0ZECczuzKnS52bfAqoeqIzMF8YCNxNWM8-yWg4g.O6OnRtBDFR_BU9tJVgoM1WPO2ncXvrFD6atVRjEpvWsg.JPEG\/%EC%8B%9D%EB%AC%BC.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":1797,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1797","url_meta":{"origin":2190,"position":1},"title":"\uacfc\ud559\uc218\uc0ac\uc758 \uc0c8 \uc9c0\ud3c9\uc744 \uc5f4\uc5b4\uc900 \uc8fc\uc778\uacf5, \u2018\uc9c0\ubb38\u2019 & \uc15c\ub85d \ud648\uc2a4\ub294 \uc65c \ud608\uc561 \ubc18\uc751 \uc2dc\uc57d\uc5d0 \uc9d1\ucc29\ud588\uc744\uae4c? &&","author":"biochemistry","date":"September 22, 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\ubc94\ud589 \ucd94\uc815 \uc2dc\uac04\uc5d0 \ub2e4\ub978 \uc7a5\uc18c\uc5d0\uc11c \ubaa9\uaca9\ub418\uc5c8\ub2e4\ub294 \uc54c\ub9ac\ubc14\uc774\uac00 \uc788\uc5c8\ub2e4.\u2026","rel":"","context":"In "Essays on Science"","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxODA3MDNfMTk5\/MDAxNTMwNTkxMDI0MjYz.xNqeUNJY0V16jZeD0sIVQxHGYqQWJPOaRqVYG5JAGqMg.bAaDgWB2A2YXNWfvmeas5SiMyM3OXEYn9zLnm6-yRdsg.JPEG\/shutterstock_1027891015.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxODA3MDNfMTk5\/MDAxNTMwNTkxMDI0MjYz.xNqeUNJY0V16jZeD0sIVQxHGYqQWJPOaRqVYG5JAGqMg.bAaDgWB2A2YXNWfvmeas5SiMyM3OXEYn9zLnm6-yRdsg.JPEG\/shutterstock_1027891015.jpg?resize=350%2C200&ssl=1 1x, 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\u2018\uc140\u2019 \uc628\ub77c\uc778\ud310 7\uc77c\uc790\uc5d0 \uc2e4\ub838\ub2e4. \uc0ac\ub78c \ubab8\uc740 \uc57d 60\uc870 \uac1c\ub098 \ub418\ub294 \uc138\ud3ec\ub85c \uc774\ub904\uc838 \uc788\ub2e4. \uc774 \uc911\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1625,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1625","url_meta":{"origin":2190,"position":3},"title":"\uc80a\uc740 \ud53c \uc218\ud608\ub85c \ub178\uc778\ubcd1 \ub9c9\ub294\ub2e4..\ud604\ub300\uc758\ud559 \uc720\ub9dd\uc0ac\uc5c5 \ub5a0\uc62c\ub77c","author":"biochemistry","date":"September 10, 2018","format":false,"excerpt":"\u00a0 \ubd88\ub85c\uc7a5\uc0dd\uc744 \ud5a5\ud55c \uc778\uac04\uc758 \uc695\ub9dd... \uadf8 \ub05d\uc740 \uc5b4\ub514\uc77c\uae4c\uc694? \u00a0 (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) \u00a0 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