![\"\"](\"https:\/\/imgnews.pstatic.net\/image\/584\/2018\/11\/26\/0000002389_001_20181126193047214.jpg?type=w647\")
<\/span><\/p>\n\uc720\uc804\uc790 \uad50\uc815\ud55c \uc544\uae30\ub97c \ud0dc\uc5b4\ub098\uac8c \ud558\ub294 \ub370 \uc131\uacf5\ud588\ub2e4\uace0 \uc8fc\uc7a5\ud55c \ud5c8\uc820\ucfe0\uc774 \uc911\uad6d\ub0a8\ubc29\uacfc\uae30\ub300 \uad50\uc218. – \uc0ac\uc9c4\uc81c\uacf5 \uc911\uad6d\ub0a8\ubc29\uacfc\uae30\ub300<\/em><\/span><\/p>\n <\/p>\n <\/p>\n \uc911\uad6d \uacfc\ud559\uc790\uac00 \uc138\uacc4 \ucd5c\ucd08\ub85c \uc720\uc804\uc790 \uac00\uc704\ub97c \uc774\uc6a9\ud574 \uc720\uc804\uc790\ub97c \uad50\uc815\ud55c \uc778\uac04 \uc544\uae30 \ucd9c\uc0b0\uc5d0 \uc131\uacf5\ud588\ub2e4\uace0 \uc8fc\uc7a5\ud588\ub2e4. \uc544\uc9c1\uc740 \ub3d9\ub8cc\ud3c9\uac00(peer<\/span>\u00a0review<\/span>) \ub4f1\uc744 \uac70\uce58\uc9c0 \uc54a\uc740 \uc77c\ubc29\uc801 \uc8fc\uc7a5\uc774\uc9c0\ub9cc, \ub9cc\uc57d \uc0ac\uc2e4\uc77c \uacbd\uc6b0 \uacfc\ud559\uacc4\uac00 \uc554\ubb35\uc801 \u2018\uae08\uae30\u2019\ub85c \uc5ec\uae30\ub358 \u2018\ub514\uc790\uc774\ub108 \ubca0\uc774\ube44(\uc6d0\ud558\ub294 \ub300\ub85c \uc720\uc804\uc790\ub97c \uc218\uc815\ud574 \ud0c4\uc0dd\uc2dc\ud0a8 \uc544\uae30)\u2019\ub97c \ub9cc\ub4e0 \uac83\uc73c\ub85c, \ud070 \uc724\ub9ac\uc801 \ub17c\ub780\uc744 \ubd88\ub7ec \uc77c\uc73c\ud0ac \uac83\uc73c\ub85c \ubcf4\uc778\ub2e4.<\/p>\n 25\uc77c(\ud604\uc9c0\uc2dc\uac01) \ubbf8\uad6d\uc758 \uacfc\ud559\u00b7\uae30\uc220 \ub9e4\uccb4 \u2018MIT<\/span>\u00a0\ud14c\ud06c\ub180\ub85c\uc9c0\ub9ac\ubdf0\u2019\uc640 26\uc77c\u00a0AP<\/span>\u00a0\ud1b5\uc2e0 \ub4f1\uc744 \uc885\ud569\ud558\uba74, \ud5c8\uc820\ucfe0\uc774(\ufffd:\u5efa\u594e) \uc911\uad6d\ub0a8\ubc29\uacfc\uae30\ub300 \uad50\uc218(\uc0ac\uc9c4)\ub294 \ubd88\uc784 \uce58\ub8cc \uc911\uc778 \ubd80\ubaa8 \uc77c\uacf1 \uba85\uc73c\ub85c\ubd80\ud130 \ubc30\uc544\ub97c \uc5bb\uc5b4 \uc720\uc804\uc790 \uad50\uc815\uc744 \ud588\ub2e4. \uc5f0\uad6c\ud300\uc740 \uadf8 \uc911 \ud55c \uc30d\uc758 \ubd80\ubaa8\ub85c\ubd80\ud130 \uc30d\ub465\uc774\ub97c \uc5bb\ub294 \ub370 \uc131\uacf5\ud588\ub2e4. \uc5b4\ub5a4 \uad50\uc815\uc774 \uc788\uc5c8\ub294\uc9c0\uc5d0 \ub300\ud574 \ud5c8 \uad50\uc218\ub294 \u201c\uc720\uc804\ubcd1\uc744 \uce58\ub8cc\ud558\uac70\ub098 \uc608\ubc29\ud560 \ubaa9\uc801\uc774 \uc544\ub2c8\uba70, \uc5d0\uc774\uc988\ub97c \uc77c\uc73c\ud0a4\ub294\u00a0HIV<\/span>\u00a0\ubc14\uc774\ub7ec\uc2a4 \uac10\uc5fc\uc5d0 \uc800\ud56d\uc131\uc744 \uac16\ub3c4\ub85d \ud558\ub294 \ud76c\uadc0\ud55c \ud615\uc9c8\uc744 \uac16\uac8c \ud588\ub2e4\u201d\uace0 \ubc1d\ud614\ub2e4.<\/p>\n \ud5c8 \uad50\uc218\uac00 26\uc77c \uc911\uad6d\uc784\uc0c1\uc13c\ud130(HhCTR<\/span>)\uc5d0 \uc62c\ub9b0 \ubb38\uc11c \u2018\uc778\uac04 \ubc30\uc544\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c\u00a0HIV<\/span>\u00a0\uba74\uc5ed \uc720\uc804\uc790\u00a0CCR<\/span>5 \uc720\uc804\uc790 \uad50\uc815\uc758 \uc548\uc804\uc131 \ubc0f \ud6a8\uc6a9\uc131 \ud3c9\uac00\u2019\uc5d0 \ub530\ub974\uba74 22~38\uc138\uc758 \ubd80\ubd80\ub97c \ub300\uc0c1\uc73c\ub85c\u00a0HIV<\/span>\uc640 \ucc9c\uc5f0\ub450, \ucf5c\ub808\ub77c \ub4f1\uacfc \uad00\ub828\uc774 \uc788\ub294\u00a0CCR<\/span>5 \uc720\uc804\uc790\ub97c \uc720\uc804\uc790 \uad50\uc815\uc744 \ud1b5\ud574 \uc81c\uac70\ud588\uace0, \uc774\ub807\uac8c \uad50\uc815\ud55c \ubc30\uc544\ub97c \uc790\uad81\uc5d0 \ucc29\uc0c1\uc2dc\ucf30\ub2e4. \uc774 \uc0ac\uc2e4\uc744 \ucd5c\ucd08 \ubcf4\ub3c4\ud55c \u2018MIT<\/span>\u00a0\ud14c\ud06c\ub180\ub85c\uc9c0\ub9ac\ubdf0\u2019\uc758 \uae30\uc0ac\uc5d0 \ub530\ub974\uba74, \ud5c8 \uad50\uc218\ub294 \uc2e4\ud5d8\uc774 \uc131\uacf5\ud588\ub290\ub0d0\ub294 \uae30\uc790\uc758 \uba54\uc77c\uacfc \uc804\ud654 \uc9c8\ubb38\uc5d0 \ub2f5\ubcc0\uc744 \uac70\ubd80\ud588\ub2e4. \ud558\uc9c0\ub9cc \uc774\uc5b4\uc9c4\u00a0AP<\/span>\u00a0\ud1b5\uc2e0\uacfc\uc758 \ub300\ud654\uc5d0\uc11c \uc774\ubc88 \ub2ec\uc5d0 \ud55c \uc30d\uc758 \uc5ec\uc131 \uc30d\ub465\uc774\ub97c \ub0b3\uc558\ub2e4\uace0 \ub2f5\ud588\ub2e4.<\/p>\n \ud604\uc7ac \ud5c8 \uad50\uc218\uc758 \uc8fc\uc7a5\uc5d0 \ub300\ud574\uc11c\ub294 \ub3d9\ub8cc\ud3c9\uac00 \ub4f1 \uad50\ucc28 \uac80\uc99d\uc774 \uc774\ub904\uc9c0\uc9c0 \uc54a\uc740 \uc0c1\ud0dc\ub2e4. \ud559\uc220\uc9c0\uc5d0 \ubc1c\ud45c\ud558\uc9c0 \uc54a\uc558\uace0, \ud654\uc694\uc77c\ubd80\ud130 \ud64d\ucf69\uc5d0\uc11c \uc5f4\ub9b4 \uc720\uc804\uc790 \uad50\uc815 \ud559\uc220\ub300\ud68c\uc5d0 \uc55e\uc11c \ub300\ud68c \uc870\uc9c1\uc704\uc6d0\ud68c\uc5d0 \uacb0\uacfc\ub97c \uba3c\uc800 \uacf5\uac1c\ud588\ub2e4. \uc774\uc5b4\u00a0AP<\/span>\u00a0\ud1b5\uc2e0\uacfc\uc758 \ub2e8\ub3c5 \uc778\ud130\ubdf0\uc5d0\uc11c \ub2e4\uc2dc \ud55c\ubc88 \uc5f0\uad6c \uacb0\uacfc\ub97c \ud655\uc778\ud588\ub2e4.<\/p>\n \uc774\uc5d0 \uc55e\uc11c \uc911\uad6d\uc740 2015\ub144 4\uc6d4\uc5d0 \uc774\ubbf8 \ud06c\ub9ac\uc2a4\ud37c\ub97c \uc774\uc6a9\ud574 \uc778\uac04 \ubc30\uc544\ub97c \uc2e4\ud5d8\uc2e4\uc5d0\uc11c \uad50\uc815\ud558\ub294 \ub370 \ucc98\uc74c \uc131\uacf5\ud574 \ud559\uc220\uc9c0 \u2018\ub2e8\ubc31\uc9c8\uacfc \uc138\ud3ec\u2019\uc5d0 \uc815\uc2dd\uc73c\ub85c \ubc1c\ud45c\ud558\uba74\uc11c \uaca9\ub82c\ud55c \uc0dd\uba85\uc724\ub9ac \ub17c\uc7c1\uc744 \uc77c\uc73c\ucf30\ub2e4. \ub9ce\uc740 \uacfc\ud559\uc790\ub4e4\uc740 \ub2f9\uc2dc \uc5f0\uad6c \uacb0\uacfc\uac00 \uacf5\uac1c\ub418\uae30 \ud55c \ub2ec \uc804\uc5d0 \ud559\uc220\uc9c0 \u2018\ub124\uc774\ucc98\u2019\ub97c \ud1b5\ud574 \uc778\uac04 \ubc30\uc544 \uc5f0\uad6c\uc5d0 \uc720\uc804\uc790 \uad50\uc815 \uae30\uc220\uc744 \uc4f0\uba74 \uc548 \ub41c\ub2e4\uace0 \ubc1d\ud78c \ucc38\uc774\ub77c \ud30c\ubb38\uc740 \ub354 \ucef8\ub2e4. \uacb0\uad6d \uadf8 \ud574 12\uc6d4 \ucd08, \ubbf8\uad6d\uad6d\ub9bd\uacfc\ud559\uc6d0\uacfc \uc601\uad6d \ub7f0\ub358\uc655\ub9bd\ud559\ud68c, \uc911\uad6d\uacfc\ud559\uc6d0 \ub4f1\uc774 \ud568\uaed8 \u2018\uc778\uac04 \uc720\uc804\uc790 \uad50\uc815\uc5d0 \uad00\ud55c \uad6d\uc81c \ud68c\ub2f4\u2019\uc774 \uc5f4\ub9ac\uac8c \ub41c \uacc4\uae30\uac00 \ub410\ub2e4.<\/p>\n \uc774\ubc88 \uc5f0\uad6c\ub294 \uc544\uc9c1 \uc815\uc2dd\uc73c\ub85c \ub3d9\ub8cc \ud3c9\uac00\ub97c \uae30\ub2e4\ub9ac\uace0 \uc788\uc5b4 \uc131\uacf5 \uc5ec\ubd80\ub97c \ub17c\ud558\uae30 \uc5b4\ub835\ub2e4. \ud558\uc9c0\ub9cc, \uc5f0\uad6c \uacb0\uacfc\uc5d0 \uc55e\uc11c \ubc30\uc544\ub97c \uc9c1\uc811 \uad50\uc815\ud574 \uc2e4\uc81c \uc544\uae30\ub97c \ud0dc\uc5b4\ub098\uac8c \ud558\ub294 \uc2e4\ud5d8\uc774 \uc9c4\ud589\ub418\uace0 \uc788\ub2e4\ub294 \uc0ac\uc2e4\ub9cc\uc73c\ub85c\ub3c4 \ud070 \ucda9\uaca9\uc744 \ubd88\ub7ec \uc77c\uc73c\ud0ac \uac83\uc73c\ub85c \ubcf4\uc778\ub2e4. \uc774\ubc88 \uc5f0\uad6c\uc758 \uad6c\uccb4\uc801\uc778 \uc804\ubaa8\ub294 \ud654\uc694\uc77c\ubd80\ud130 \uc9c4\ud589\ub420 \ud559\uc220\ub300\ud68c\uc5d0\uc11c \ub4dc\ub7ec\ub0a0 \uc804\ub9dd\uc774\ub2e4.<\/p>\n <\/p>\n <\/p>\n \uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~<\/p>\n <\/p>\n <\/p>\n <\/p>\n \u4e2d \uacfc\ud559\uc790 “\uc218\uc815\ub780 \uad50\uc815” \uc8fc\uc7a5\u2026 \uc911\uad6d \uacfc\ud559\uc790\ub4e4, \ube44\ub09c \uc131\uba85 \ubc1c\ud45c <\/p>\n \uc911\uad6d\uc5d0\uc11c \uc720\uc804\uc790 \uac00\uc704\ub85c\u00a0DNA<\/span>\ub97c \uad50\uc815\ud55c \uc544\uae30\uac00 \ucd9c\uc0dd\ud588\ub2e4\ub294 \uc8fc\uc7a5\uc774 \ub098\uc624\uba74\uc11c \uc138\uacc4 \uacfc\ud559\uacc4\uac00 \uac70\uc13c \ud6c4\ud3ed\ud48d\uc5d0 \ud729\uc2f8\uc600\ub2e4. \uc720\uc804\uc790 \uac00\uc704\ub294 \ud2b9\uc815 \uc720\uc804\uc790\ub97c \ub9c8\uc74c\ub300\ub85c \uc798\ub77c\ub0b4\uace0 \uad50\uc815\ud560 \uc218 \uc788\ub294 \ud6a8\uc18c \ub2e8\ubc31\uc9c8\ub85c \ucc28\uc138\ub300 \uc720\uc804\uc9c8\ud658 \uce58\ub8cc \uae30\uc220\ub85c \uac01\uad11\ubc1b\uace0 \uc788\ub2e4. \ud558\uc9c0\ub9cc \uc544\uc9c1 \ub300\ubd80\ubd84 \uad6d\uac00\uc5d0\uc11c\ub294 \uc720\uc804\uc790 \uad50\uc815 \uc544\uae30\uc758 \ucd9c\uc0b0\uc744 \ud5c8\uc6a9\ud558\uc9c0 \uc54a\uace0 \uc788\uc5b4 \ud5a5\ud6c4 \uc724\ub9ac \ub17c\ub780\uc774 \uac70\uc138\uc9c8 \uc804\ub9dd\uc774\ub2e4.<\/p>\n \uc9c0\ub09c 26\uc77c(\ud604\uc9c0 \uc2dc\uac01) \uc911\uad6d \uc120\uc804 \ub0a8\ubc29\uacfc\uae30\ub300\uc758 \ud5c8\uc820\ucfe0\uc774(\u8cc0\u5efa\u594e) \ubc15\uc0ac\ub294 \uc720\ud29c\ube0c \uc601\uc0c1\uc744 \ud1b5\ud574 “\uc720\uc804\uc790 \uac00\uc704\ub97c \uc774\uc6a9\ud574 \uc5d0\uc774\uc988(AIDS<\/span>\u00b7\ud6c4\ucc9c\uc131\uba74\uc5ed\uacb0\ud54d\uc99d)\uc5d0 \uba74\uc5ed\ub825\uc744 \uac16\ub3c4\ub85d \uc720\uc804\uc790\ub97c \uad50\uc815\ud55c \uc30d\ub465\uc774 \uc544\uae30\uac00 \ud0c4\uc0dd\ud588\ub2e4”\uace0 \ubc1c\ud45c\ud588\ub2e4.<\/p>\n \ud5c8\uc820\ucfe0\uc774 \ubc15\uc0ac\ub294 \uc720\uc804\uc790 \uac00\uc704\ub85c \uc0ac\ub78c \uc218\uc815\ub780\uc5d0\uc11c\u00a0CCR<\/span>5 \uc720\uc804\uc790\ub97c \uc791\ub3d9\ud558\uc9c0 \ubabb\ud558\ub3c4\ub85d \ud588\ub2e4\uace0 \ubc1d\ud614\ub2e4.\u00a0CCR<\/span>5\ub294 \uc5d0\uc774\uc988\ub97c \uc77c\uc73c\ud0a4\ub294\u00a0HIV<\/span>\u00a0\ubc14\uc774\ub7ec\uc2a4\ub97c \uc0ac\ub78c \uc138\ud3ec \uc548\uc73c\ub85c \ub4e4\uc5ec\ubcf4\ub0b4\ub294 \ub2e8\ubc31\uc9c8 \uc0dd\uc0b0\uc5d0 \uad00\uc5ec\ud55c\ub2e4. \uacfc\ud559\uacc4\uc5d0\uc11c\ub294 \uc5f0\uad6c\uac00 \uc5b4\ub290 \uc815\ub3c4 \uc131\uacf5\ud55c \uac83\uc73c\ub85c \ubc1b\uc544\ub4e4\uc774\uace0 \uc788\ub2e4.<\/p>\n \ud5c8\uc820\ucfe0\uc774 \ubc15\uc0ac\uc758 \ubc1c\ud45c\uc640 \ub3d9\uc2dc\uc5d0 \ube44\ud310\uc774 \uc3df\uc544\uc84c\ub2e4. \uc911\uad6d \uc120\uc804\uc2dc \uc758\ub8cc\uc724\ub9ac\uc804\ubb38\uac00\uc704\uc6d0\ud68c\ub294 \uac19\uc740 \ub0a0 \ud5c8\uc820\ucfe0\uc774 \ubc15\uc0ac\uc5d0 \ub300\ud55c \uc9c4\uc0c1 \uc870\uc0ac\uc5d0 \ucc29\uc218\ud558\uaca0\ub2e4\uace0 \ubc1c\ud45c\ud588\ub2e4. \ub2f9\ucd08 \uc54c\ub824\uc9c4 \uac83\uacfc \ub2ec\ub9ac \ud574\ub2f9 \uc5f0\uad6c\ub294 \ud559\uad50 \uce21\uc758 \ud5c8\uac00\ub97c \ubc1b\uc9c0 \uc54a\uc558\ub358 \uac83\uc73c\ub85c \ud655\uc778\ub410\ub2e4. \ub0a8\ubc29\uacfc\uae30\ub300 \uce21\uc740 “\uc774\ubc88 \uc5f0\uad6c\ub294 \ud559\uad50\uc640 \uc544\ubb34\ub7f0 \uad00\ub828\uc774 \uc5c6\uc73c\uba70 \ud559\uad50 \uc5f0\uad6c\uc2dc\uc124\uc5d0\uc11c \uc774\ub904\uc9c0\uc9c0 \uc54a\uc558\ub2e4”\uba70 “\uc2ec\uac01\ud55c \uc724\ub9ac \uc704\ubc18\uc774\uc790 \ud559\uacc4 \uae30\uc900\uc744 \uc5b4\uae34 \ud589\uc704”\ub77c\uace0 \ubc1c\ud45c\ud588\ub2e4. \ud5c8\uc820\ucfe0\uc774 \ubc15\uc0ac\ub294 \uc5f0\uad6c \uacb0\uacfc\ub97c \uad6d\uc81c \ud559\uc220\uc9c0\uc5d0 \ubc1c\ud45c\ud558\uc9c0\ub3c4 \uc54a\uc558\ub2e4.<\/p>\n \ud559\uacc4\uc758 \ube44\ub09c\ub3c4 \uac70\uc138\ub2e4. \uc911\uad6d \ub0b4 \uacfc\ud559\uc790 122\uba85\uc740 \uacf5\ub3d9 \uc131\uba85\uc744 \ud1b5\ud574 “\uc774\ubc88 \uc5f0\uad6c\ub85c \uc911\uad6d \uc0dd\uba85\uacfc\ud559 \ubc1c\uc804\uc5d0 \ud070 \ud0c0\uaca9\uc744 \uc785\uc5c8\ub2e4”\uace0 \ube44\ud310\ud588\ub2e4. 3\uc138\ub300 \uc720\uc804\uc790 \uac00\uc704 \uae30\uc220\uc778 \ud06c\ub9ac\uc2a4\ud37c\uc758 \ucc3d\uc2dc\uc790\uc778 \ud3ad\uc7a5 \ubbf8\uad6d \ub9e4\uc0ac\ucd94\uc138\uce20\uacf5\ub300(MIT<\/span>) \uad50\uc218\ub3c4 “\uc774\ubc88 \uc5f0\uad6c\uac00 \ube44\ubc00\uc5d0 \ubd80\uccd0\uc9c4 \ucc44 \uc9c4\ud589\ub41c \ub370 \ub300\ud574 \uc2ec\ud788 \uc720\uac10”\uc774\ub77c\uba70 “\uc720\uc804\uc790 \uad50\uc815 \uc544\uae30 \uc5f0\uad6c\uc758 \ubaa8\ub77c\ud1a0\ub9ac\uc5c4(\uc911\ub2e8)\uc744 \uc694\uad6c\ud55c\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/p>\n <\/p>\n <\/p>\n \uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~<\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n \uc724\ub9ac \ub17c\ub780 \uc774\uc5b4 “\ub2e4\uc2dc \ubcf4\uc790”\uc2e0\uc911\ub860\uae4c\uc9c0 \ub4f1\uc7a5<\/strong><\/p>\n <\/p>\n \ud5c8\uc820\ucfe0\uc774 \uc911\uad6d \ub09c\ud321\uacfc\ud559\uae30\uc220\ub300 \uad50\uc218\uac00 28\uc77c \ud64d\ucf69\uc5d0\uc11c \uc5f4\ub9b0 \ucf58\ud37c\ub7f0\uc2a4\uc5d0\uc11c \uc720\uc804\uc790\ub97c \uc218\uc815\ud55c \uc30d\ub465\uc774 \uc544\uae30\ub97c \ud0dc\uc5b4\ub098\uac8c \ud558\ub294\ub370 \uc131\uacf5\ud588\ub2e4\uace0 \ubc1d\ud614\ub2e4.\u00a0AP<\/span>\/\uc5f0\ud569\ub274\uc2a4<\/em><\/span><\/p>\n <\/p>\n \ucd9c\uc0b0 \uc0ac\uc2e4\uc774 \uacf5\uac1c\ub418\uba74\uc11c \uacfc\ud559\uacc4\ub294 \ubb3c\ub860 \uc804 \uc138\uacc4\uc801\uc73c\ub85c \ud070 \ud30c\ubb38\uc774 \uc77c\uace0 \uc788\ub294 \uc720\uc804\uc790 \uad50\uc815 \uc544\uae30 \uc5f0\uad6c \ubb38\uc81c\uac00 \uc0c8\ub85c\uc6b4 \uad6d\uba74\uc5d0 \uc811\uc5b4\ub4e4\uace0 \uc788\ub2e4. \uc5f0\uad6c\uc790\uc778 \ud5c8\uc820\ucfe0\uc774 \uc911\uad6d \ub09c\ud321\uacfc\uae30\ub300 \uad50\uc218 \uc790\uc2e0\uc774 28\uc77c \ud64d\ucf69\uc5d0\uc11c \uc5f4\ub9b0 \uc778\uac04\uc720\uc804\uccb4\uad50\uc815 \uad6d\uc81c\ud68c\uc758\uc5d0\uc11c \uc5b8\ub860 \ubcf4\ub3c4\ub97c \ud1b5\ud574 \uc54c\ub824\uc838 \uc788\ub358 \uc720\uc804\uc790 \uad50\uc815 \uc544\uae30 \ucd9c\uc0b0 \uc0ac\uc2e4\uc744 \uacf5\uc2dd \uc778\uc815\ud55c \uac00\uc6b4\ub370, \uc911\uad6d \uc815\ubd80\ub294 \ubb3c\ub860 \uc138\uacc4 \ub300\ub2e4\uc218 \ud559\uc790\ub4e4\uc774 \uc774\uc5d0 \ub300\ud55c \ubd80\uc815\uc801\uc778 \uc785\uc7a5\uc744 \uacf5\uac1c\uc801\uc73c\ub85c \ubc1d\ud788\uace0 \uc788\ub2e4. \ud558\uc9c0\ub9cc \uc870\uc9c0 \ucc98\uce58 \ubbf8\uad6d \ud558\ubc84\ub4dc\ub300 \uad50\uc218 \ub4f1 \uc77c\ubd80 \uc5f0\uad6c\uc790\ub4e4\uc774 \ud5c8 \uad50\uc218\ub97c \uc639\ud638\ud558\ub294 \ub73b\uc744 \ubc1d\ud788\uba74\uc11c \ub17c\ub780\uc774 \uae38\uc5b4\uc9c8 \uac83\uc774\ub780 \ubd84\uc11d\uc774 \ub098\uc628\ub2e4.<\/p>\n \ud5c8 \uad50\uc218\ub294 \uc778\uac04 \ubc30\uc544\ub97c \ub300\uc0c1\uc73c\ub85c \uc5d0\uc774\uc988 \uac10\uc5fc\uc5d0 \uad00\uc5ec\ud558\ub294 \ub2e8\ubc31\uc9c8\u00a0CCR<\/span>5\ub97c \uc81c\uac70\ud558\ub294 \uc2e4\ud5d8\uc744 \ud588\ub2e4.\u00a0HIV<\/span>\u00a0\uac10\uc5fc \uacbd\ub85c\ub97c \ucc28\ub2e8\uc2dc\ucf1c \uc9c8\ubcd1\uc744 \uc608\ubc29\ud558\uac8c \ud55c \uc544\uae30\ub97c \ud0dc\uc5b4\ub098\uac8c \ud558\ub824 \ud588\ub2e4\ub294 \uac8c \ud5c8 \uad50\uc218\uc758 \uc8fc\uc7a5\uc774\ub2e4. \uc5b8\ub73b \uc911\uc694\ud558\uace0 \uc22d\uace0\ud55c \uc758\ud559\uc801 \ubaa9\uc801\uc744 \uc9c0\ub2cc \uc2dc\uae09\ud55c \uc5f0\uad6c\ub97c \uc131\uacf5\uc2dc\ud0a8 \uac83 \uac19\ub2e4. \ud558\uc9c0\ub9cc \ud06c\uac8c \ub450 \uac00\uc9c0 \uba74\uc5d0\uc11c \ud070 \ube44\ud310\uacfc \ub17c\ub780\uc744 \ub0b3\uace0 \uc788\ub2e4.<\/p>\n \uba3c\uc800 \uc778\uac04 \ubc30\uc544\uc5d0 \ub300\ud55c \uc720\uc804\uc790 \uad50\uc815 \ub610\ub294 \uc218\uc815 \uc2e4\ud5d8\uc740 \ubc30\uc544\uac00 \ucc29\uc0c1\ub420 \uacbd\uc6b0 \uc2e4\uc81c\ub85c \uc720\uc804\uc790\uac00 \uad50\uc815\ub41c \uc778\uac04\uc774 \ud0c4\uc0dd\ud560 \uc218 \uc788\ub2e4\ub294 \uc810 \ub54c\ubb38\uc5d0 \uac15\ub825\ud55c \uc724\ub9ac\uc801 \ub17c\uc7c1\uc744 \ubd88\ub7ec\uc77c\uc73c\ud0a4\ub294 \uc8fc\uc81c\ub2e4. \ubc30\uc544\ub294 \uc5ec\ub7ec \uad6d\uac00\uc5d0\uc11c \uc624\uc9c1 \ud76c\uadc0\ubcd1\uc774\ub098 \ub09c\uce58\ubcd1\uc744 \uce58\ub8cc\ud558\uae30 \uc704\ud55c \uae30\ucd08\uc5f0\uad6c\uc5d0\ub9cc \uc608\uc678\uc801\uc778 \uc5f0\uad6c\ub97c \ud5c8\uc6a9\ud558\uace0 \uc788\ub2e4. \ud55c\uad6d\uc740 \uc774\uc870\ucc28 \ubc95\uc73c\ub85c \uc815\ud574\uc9c4 \ud2b9\uc815 \uc9c8\ud658\uc5d0\ub9cc \ud5c8\uc6a9\ub420 \ub9cc\ud07c \uc5c4\uaca9\ud788 \uaddc\uc81c\ub418\uace0 \uc788\uace0(\ud3ec\uc9c0\ud2f0\ube0c \uaddc\uc81c), \ud2b9\ud788 \ubc30\uc544\ub098 \uc0dd\uc2dd\uc138\ud3ec\ub97c \uc720\uc804\uc801\uc73c\ub85c \ubcc0\ud615\uc2dc\ud0a4\ub294 \uc720\uc804\uc790 \uce58\ub8cc\ub294 \uc544\uc608 \uae08\uc9c0\ub3fc \uc788\ub2e4.<\/p>\n \ucd5c\uc2e0 \uc720\uc804\uc790 \uad50\uc815 \uae30\uc220\uc778 ‘\ud06c\ub9ac\uc2a4\ud37c’\ub294 \uc6cc\ub099 \uac15\ub825\ud55c \uc720\uc804\uc790 \uad50\uc815 \ub2a5\ub825\uc744 \uc9c0\ub2c8\uace0 \uc788\uae30 \ub54c\ubb38\uc5d0, \uc774 \uae30\uc220\uc774 \uc778\uac04 \ubc30\uc544\ub97c \uc218\uc815\ud558\uace0 \uc774\ub97c \ubc14\ud0d5\uc73c\ub85c \ub514\uc790\uc774\ub108 \ubca0\uc774\ube44\ub97c \ud0c4\uc0dd\uc2dc\ud0ac \uac00\ub2a5\uc131\uc744 \uc5f0\uad6c\uc790\ub4e4\ub3c4 \uc798 \uc54c\uace0 \uc788\uc5c8\ub2e4. \uc774\uc5d0 2015\ub144 12\uc6d4 \ucd08, \ubbf8\uad6d\uad6d\ub9bd\uacfc\ud559\uc6d0\uacfc \uc758\ud559\uc6d0, \uc601\uad6d\uc655\ub9bd\ud559\ud68c, \uc911\uad6d\uacfc\ud559\uc6d0 \ub4f1 \uc720\uc804\uc790 \uad50\uc815 \uc5f0\uad6c\ub97c \uc120\ub3c4\ud558\ub294 \uc5ec\ub7ec \uad6d\uac00\uc758 \uc5f0\uad6c\uc790\ub4e4\uc774 \uc790\uccb4\uc801\uc73c\ub85c \ubbf8\uad6d \uc6cc\uc2f1\ud134\uc5d0 \ubaa8\uc5ec \uc720\uc804\uc790\uac00\uc704\ub97c \uc0ac\uc6a9\ud588\uc744 \ub54c \ubc8c\uc5b4\uc9c8 \uc218 \uc788\ub294 \uc724\ub9ac\uc801 \ubb38\uc81c\ub97c \uc790\uccb4\uc801\uc73c\ub85c \ub17c\uc758\ud558\uace0, \uc790\uccb4\uc801\uc73c\ub85c \u201c\uc0ac\ud68c\uc801 \ud569\uc758\uac00 \uc788\uae30 \uc804\uc5d0\ub294 \uc720\uc804\uc790 \uac00\uc704\ub97c \uc774\uc6a9\ud574 \uad50\uc815\ud55c \uc778\uac04 \ubc30\uc544\ub97c \uc751\uc6a9\ud558\uc9c0 \uc54a\uac8c \ud558\uc790\u201d\ub294 \uc131\uba85\uc744 \ubc1c\ud45c\ud588\ub2e4. \uc774 \ub54c \uc751\uc6a9\uc774\ub780 \ub2e4\ub984 \uc544\ub2c8\ub77c \uc2e4\uc81c\ub85c \uc720\uc804\uc790\ub97c \ubc14\uafbc \uc544\uae30, \u2018\ub514\uc790\uc774\ub108 \ubca0\uc774\ube44(\uc720\uc804\uc790 \ub9de\ucda4\ud615 \uc544\uae30)\u2019\uc758 \ud0c4\uc0dd\uc744 \uc758\ubbf8\ud55c\ub2e4.<\/p>\n <\/p>\n <\/p>\n \ud558\uc9c0\ub9cc \uc774\ubc88 \ud5c8 \uad50\uc218\uc758 \uc5f0\uad6c\ub294 \uc774\ub7f0 \ud569\uc758\ub97c \uc0ac\uc2e4\uc0c1 \ubb34\ub2e8\uc73c\ub85c \uae7c\ub2e4. \ubc30\uc544\ub97c \uc544\ubb34\ub7f0 \uc0ac\ud68c\uc801 \ud569\uc758 \uc5c6\uc774 \ucc29\uc0c1\uc2dc\ucf1c \uc2e4\uc81c \uc544\uae30\ub97c \ud0dc\uc5b4\ub098\uac8c \ud588\ub2e4. \uc911\uad6d\uc740 \uc778\uac04 \ubc30\uc544\ub97c \uc720\uc804\uc790 \uad50\uc815\ud55c \uccab \ubc88\uc9f8 \ub17c\ubb38\uc744 2015\ub144 \ucd08\uc5d0 \ubc1c\ud45c\ud574 \uc138\uc0c1\uc744 \ub180\ub77c\uac8c \ud588\uc744 \ub9cc\ud07c \uc778\uac04 \ubc30\uc544 \uad50\uc815 \uc5f0\uad6c\uac00 \ud65c\ubc1c\ud588\ub358 \ub098\ub77c\ub2e4. \ud558\uc9c0\ub9cc \uadf8\ub7f0 \uc911\uad6d\uc5d0\uc11c\ub3c4 \uadf8 \ubc30\uc544\ub97c \ucc29\uc0c1\uc2dc\ucf1c \ucd9c\uc0b0\uc5d0 \uc774\ub974\uac8c \ud558\ub294 \uc77c\uc740 \ucda9\uaca9\uc73c\ub85c \ubc1b\uc544\ub4e4\uc5ec\uc9c0\uace0 \uc788\ub2e4. \ud06c\ub9ac\uc2a4\ud37c\ub97c \uc9c4\ud575\uc0dd\ubb3c\uc744 \ub300\uc0c1\uc73c\ub85c \ud655\ub9bd\ud55c \uc774 \ubd84\uc57c \uc11d\ud559 \uc7a5\ud391 \ubbf8\uad6d \ube0c\ub85c\ub4dc\uc5f0\uad6c\uc18c \uad50\uc218\ub294 \uc18c\uc2dd\uc774 \uc54c\ub824\uc9c4 \uc9c1\ud6c4 \u2018MIT<\/span>\u00a0\ud14c\ud06c\ub180\ub85c\uc9c0 \ub9ac\ubdf0\u2019\ub97c \ud1b5\ud574 \uac15\ud55c \ube44\ud310\uc744 \uac00\ud588\ub2e4. \uadf8\ub294 \uc911\uad6d\uc5d0\uc11c \ud589\ud574\uc9c0\ub294 \ube44\ubc00 \ud504\ub85c\uc81d\ud2b8\uc5d0 \u201c\uae4a\uc740 \uc6b0\ub824\u201d\ub97c \ud45c\ud558\uba70 \u201c\uad50\uc815\ub41c \ubc30\uc544\uc758 \uc774\uc2dd\uc5d0 \ub300\ud574 \ubaa8\ub77c\ud1a0\ub9ac\uc5c4\uc744 \uc120\uc5b8\ud558\uaca0\ub2e4\u201d\uace0 \ub9d0\ud588\ub2e4.<\/p>\n \uae09\uae30\uc57c \uc26c\ub09c\ud551 \uc911\uad6d \uacfc\ud559\uae30\uc220\ubd80 \ubd80\ubd80\uc7a5(\ucc28\uad00)\uc740 29\uc77c\u00a0CCTV<\/span>\uc640\uc758 \uc778\ud130\ubdf0\uc5d0\uc11c \u201c\uc0dd\uc2dd \ubaa9\uc801\uc758 \uc778\uac04 \ubc30\uc544 \uc720\uc804\uc790 \uad50\uc815\uc740 \uc911\uad6d\uc5d0\uc11c \uae08\uc9c0\ub3fc \uc788\ub2e4\u201d\uba70 \u201c\ubc95\uaddc\ub3c4 \uc704\ubc18\ud588\uace0, \uacfc\ud559\uacc4\uc758 \uc724\ub9ac \ub9c8\uc9c0\ub178\uc120\uc744 \uae68\ubc84\ub9b0 \ub180\ub77c\uc6b4 \uc77c\u201d\uc774\ub77c\uba70 \u201c\uac1d\uad00\uc801 \uc870\uc0ac\ub97c \uae30\ucd08\ub85c \ubc95\uc5d0 \ub530\ub77c \uc870\uc0ac, \ucc98\ub9ac\ud558\uaca0\ub2e4\u201d\uace0 \ubc1d\ud614\ub2e4. \uc26c \ubcf8\ubd80\uc7a5\uc740 \ud5c8 \uad50\uc218\uc758 \uc5f0\uad6c \ud65c\ub3d9\ub3c4 \uc911\ub2e8\uc2dc\ud0ac \uac83\uc744 \uc694\uad6c\ud588\ub2e4.<\/p>\n 29\uc77c, \uae40\uc9c4\uc218 \uae30\ucd08\uacfc\ud559\uc5f0\uad6c\uc6d0(IBS<\/span>) \uc720\uc804\uccb4\uad50\uc815\uc5f0\uad6c\ub2e8\uc7a5\uc744 \ud3ec\ud568\ud574, \uc774\ubc88\uc5d0 \ud5c8 \uad50\uc218\uac00 \ucc38\uc11d\ud588\ub358 \ud559\ud68c\uc758 \uc870\uc9c1\uc704\uc6d0\ud68c\ub3c4 \uacf5\ub3d9\uc131\uba85\uc744 \ubc1c\ud45c\ud588\ub2e4. \uc704\uc6d0\ud68c\uc5d0\ub294 \u201c\ub9e4\uc6b0 \ubd88\uc628\ud55c \uc8fc\uc7a5\uc744 \uc774\ubc88 \ud559\ud68c\uc5d0\uc11c \ub4e4\uc5c8\ub2e4\u201d\uba70 \u201c\uc8fc\uc7a5\uc744 \ub3c5\ub9bd\uc801\uc73c\ub85c \uac80\uc99d\ud560 \uac83\uc744 \ucd94\ucc9c\ud558\uba70, \uc124\uc0ac \uac80\uc99d\uc774 \ub418\ub354\ub77c\ub3c4 \uc808\ucc28\uac00 \ubb34\ucc45\uc784\ud55c\ub370\ub2e4 \uad6d\uc81c\uc801 \uaddc\ubc94\uc744 \uc9c0\ud0a4\uc9c0 \ubabb\ud574 \ud760\uacb0\uc744 \uc9c0\ub2c8\uace0 \uc788\ub2e4\u201d\uace0 \ubc1d\ud614\ub2e4. \uc704\uc6d0\ud68c\ub294 \u201c\uadf8 \ud760\uacb0\uc740 \uc758\ud559\uc801 \uc808\ucc28, \uc798\ubabb \uc124\uacc4\ub41c \uc5f0\uad6c \uc808\ucc28, \uc5f0\uad6c \ud53c\uc2e4\ud5d8\uc790\uc758 \ud6c4\uc0dd\uc744 \ubcf4\ud638\ud558\uae30 \uc704\ud55c \uc724\ub9ac \uae30\uc900 \ubbf8\ucda9\uc871, \uc784\uc0c1 \uc804 \uacfc\uc815\uc758 \ubd88\ud22c\uba85\uc131 \ub4f1\uc744 \ud3ec\ud568\ud558\uace0 \uc788\ub2e4\u201d\uace0 \ube44\ud310\ud588\ub2e4.<\/p>\n <\/p>\n \ud06c\ub9ac\uc2a4\ud37c\ub97c \ud655\ub9bd\uc2dc\ud0a8 \ub450 \uc11d\ud559, \uc7a5\ud391 \ubbf8\uad6d \ube0c\ub85c\ub4dc\uc5f0\uad6c\uc18c \uad50\uc218(\uc67c\ucabd)\uacfc \uc81c\ub2c8\ud37c \ub2e4\uc6b0\ub4dc\ub098 \ubbf8\uad6d \uce98\ub9ac\ud3ec\ub2c8\uc544\ub300 \uad50\uc218. \ub450 \uc0ac\ub78c \ubaa8\ub450 \uac01\uac01 \uc774\ubc88 \uc0ac\ud0dc\uc5d0 \ube44\ud310\uc801\uc778 \uc785\uc7a5\uc744 \uc804\ud588\ub2e4.<\/em><\/span><\/p>\n <\/p>\n \ubc95\uacfc \uc724\ub9ac\ub97c \ub5a0\ub098\uc11c, \uc774\ubc88 \uc5f0\uad6c \uc790\uccb4\uc5d0\ub3c4 \uc758\ubb38\uc774 \ub9ce\ub2e4\ub294 \uc9c0\uc801\ub3c4 \ub9ce\ub2e4.\uc774\ubc88 \ud64d\ucf69 \ud559\ud68c\uc5d0\uc11c \ud5c8 \uad50\uc218\uc758 \ubc1c\ud45c\ub97c \ub4e4\uc740 \uae40\uc9c4\uc218 \ub2e8\uc7a5\uc740 30\uc77c \uc790\uc2e0\uc758 \ud398\uc774\uc2a4\ubd81\uc5d0 \u201c\uc65c \uc774\ub807\uac8c \ubb34\ubaa8\ud558\uace0 \ubb34\ucc45\uc784\ud55c \uc120\ud0dd\uc744 \ud588\ub294\uc9c0 \uc758\ubb38\u201d\uc774\ub77c\uba70 \u201c\uc774\ubc88 \uc2e4\ud5d8\uc73c\ub85c \ud0dc\uc5b4\ub09c \uc30d\ub465\uc774 \uc911 \ud55c \uba85\uc778 \u2018\ub8e8\ub8e8\u2019\ub294\u00a0CCR<\/span>5 \uc720\uc804\uc790\uac00 \uc5c6\uc774 \ud0dc\uc5b4\ub0ac\uace0, \ub610\ub2e4\ub978 \uc544\uae30 \u2018\ub098\ub098\u2019\ub294 \ud55c \uc30d\uc758\u00a0CCR<\/span>5 \uc720\uc804\uc790 \uc911 \ud558\ub098\ub294 \uadf8\ub300\ub85c, \ub098\uba38\uc9c0 \ud558\ub098\ub294 \uc77c\ubd80(15\uac1c \uc5fc\uae30\uc11c\uc5f4)\uac00 \uacb0\uc5ec\ub41c \ubcc0\uc774 \uc720\uc804\uc790\ub97c \uac16\uace0 \ud0dc\uc5b4\ub0ac\ub2e4\u201d\uace0 \ubc1d\ud614\ub2e4.<\/p>\n \ud2b9\ud788 \ub098\ub098\uc758 \ubcc0\uc774 \uc720\uc804\uc790\ub294 (15\uac1c \uc5fc\uae30\uc11c\uc5f4 \uacb0\uc5ec\uc5d0 \ub530\ub978) 5\uac1c \uc544\ubbf8\ub178\uc0b0\uc774 \uc0ac\ub77c\uc9c4 \ubcc0\uc774\u00a0CCR<\/span>5\ub97c \uc9c0\ub2c8\uace0 \ud0dc\uc5b4\ub0ac\ub294\ub370, \uc774 \ubcc0\uc774\u00a0CCR<\/span>5 \ub2e8\ubc31\uc9c8\uc774 \ud2b9\ud788 \ud070 \uc6b0\ub824\ub97c \uc790\uc544\ub0b4\uace0 \uc788\ub2e4. \uc790\uc5f0\uc5d0 \uc874\uc7ac\ud558\uc9c0 \uc54a\uc740 \ubcc0\uc774\uae30 \ub54c\ubb38\uc774\ub2e4. \uc5d0\uc774\uc988\ub97c \uc77c\uc73c\ud0a4\ub294\u00a0HIV<\/span>\ub97c \ud53c\ud560 \uc218 \uc788\uc744\uc9c0 \ubbf8\uc9c0\uc218\uc778 \uac83\uc740 \ubb3c\ub860\uc774\uace0, \uc608\uce21 \ubabb\ud55c \ub2e4\ub978 \ud615\uc9c8\uc744 \ubcf4\uc77c \uc218\ub3c4 \uc788\ub2e4. \uc608\ub97c \ub4e4\uc5b4 \uc0c8\ub85c\uc6b4 \ubc14\uc774\ub7ec\uc2a4 \uac10\uc5fc\uc744 \ub3d5\ub294 \uc5ed\ud560\uc744 \ud560\uc9c0, \ub2e4\ub978 \ubcd1\uc744 \uc720\ubc1c\ud560\uc9c0 \uc544\ubb34\ub3c4 \ubaa8\ub978\ub2e4. \uc7a0\uc7ac\uc801\uc778 \uc704\ud5d8\uc5d0 \ub300\ud55c \ubd88\ud655\uc2e4\uc131\uc774 \ub108\ubb34\ub098 \ud06c\ub2e4.<\/p>\n \uc774\uc644 \ubc84\ub2c8 \uc720\ub7fd\uc0dd\uba85\uc815\ubcf4\ud559\uc5f0\uad6c\uc18c(EMBL<\/span>–EBI<\/span>) \uc18c\uc7a5\ub3c4 \uad00\ub828 \ubcf4\ub3c4\uac00 \ucc98\uc74c \ub098\uc628 \ubbf8\uad6d \uacfc\ud559\uae30\uc220 \uc7a1\uc9c0 \u2018MIT<\/span>\u00a0\ud14c\ud06c\ub180\ub85c\uc9c0 \ub9ac\ubdf0\u2019\uc640\u00a0AP<\/span>\ud1b5\uc2e0\uc758 \ub274\uc2a4\uac00 \ubcf4\ub3c4\ub41c \uc9c1\ud6c4, \uc790\uc2e0\uc758 \ud648\ud398\uc774\uc9c0\uc5d0\uc11c \u201c\uc774\ubbf8 \uc218\uc2ed \ub144 \uc804\ubd80\ud130 \uc2dc\ud5d8\uad00 \uc544\uae30\ub97c \ud0dc\uc5b4\ub098\uac8c \ud560 \ub54c \ucc29\uc0c1 \uc804\uc5d0 \ud558\ub294 \uc720\uc804\uc9c4\ub2e8(PGD<\/span>)\uc73c\ub85c \ucda9\ubd84\ud788 \uc774\uc0c1\uc774 \uc5c6\ub294 \uc218\uc815\ub780\uc744 \uace0\ub97c \uc218 \uc788\ub2e4\u201d\uba70 \uc5f0\uad6c \ubaa9\uc801\uc5d0 \uc758\ubb38\uc744 \ud45c\ud588\ub2e4. \ubc84\ub2c8 \uc18c\uc7a5\uc740 \u201c\uc218\ub9ce\uc740 \ub3d9\ubb3c \ubc30\uc544 \uc5f0\uad6c\ub97c \ud1b5\ud574 \ud06c\ub9ac\uc2a4\ud37c\uc758 \uc548\uc804\uc131\uc744 \ub354 \ud560\uac8c \ub41c \ub4a4\uc5d0\uc57c \uc774 \uae30\uc220\uc744 \uc5b4\ub5bb\uac8c \ucc45\uc784\uac10\uc788\uac8c \uc0ac\uc6a9\ud560 \uc218 \uc788\uc744\uc9c0 \uc54c\uac8c \ub420 \uac83\u201d\uc774\ub77c\uba70 \u201c\uc774\ub294 \ub9ce\uc740 \uc5f0\uad6c\uc640 \uaddc\uc81c\uac00 \ud544\uc694\ud55c \uc77c\uc774\uba70, \ud544\uc694\ud558\ub2e4\uba74 \uc778\uac04 \ubc30\uc544\uc5d0 \ub300\ud55c \ud06c\ub9ac\uc2a4\ud37c \uc774\uc6a9\uc744 \uacb0\uc815\ud558\uae30 \uc804\uae4c\uc9c0 \ubc1b\uc544\ub4e4\uc77c \ub9cc\ud55c \uaddc\uc81c\ub97c \uace0\ub824\ud574 \ubcf4\ub294 \uac83\ub3c4 \ud544\uc694\ud558\ub2e4\u201d\uace0 \ub9d0\ud588\ub2e4.<\/p>\n <\/p>\n \uc870\uc9c0 \ucc98\uce58 \ubbf8\uad6d \ud558\ubc84\ub4dc\ub300 \uad50\uc218. -\uc0ac\uc9c4 \uc81c\uacf5\u00a0MaynardClark<\/span>(W)<\/em><\/span><\/p>\n <\/p>\n \uc774\ub7f0 \uac00\uc6b4\ub370, \uac8c\ub188 \ubd84\uc57c\uc758 \uc138\uacc4\uc801 \uc11d\ud559 \uc911 \ud558\ub098\uc778 \uc870\uc9c0 \ucc98\uce58 \ubbf8\uad6d \ud558\ubc84\ub4dc\ub300 \uad50\uc218\uac00 \ubd80\ubd84\uc801\uc73c\ub85c \ud5c8 \uad50\uc218\ub97c \uc639\ud638\ud558\uace0 \ub098\uc130\ub2e4. \ucc98\uce58 \uad50\uc218\ub294 28\uc77c \uacfc\ud559\uc7a1\uc9c0 \uacb8 \ud559\uc220\uc9c0 \u2018\uc0ac\uc774\uc5b8\uc2a4\u2019\uc640\uc758 \uc778\ud130\ubdf0\uc5d0\uc11c “(\uc77c\ubc29\uc801 \uc8fc\uc7a5 \ub9d0\uace0) \uade0\ud615\uc744 \uac16\uace0 \uc811\uadfc\ud574\uc57c \ud55c\ub2e4”\uba70 “\uc5f0\uad6c\uc5d0 \ub300\ud55c \uc11c\ub958 \uc791\uc5c5\uc774 \uc81c\ub300\ub85c \uc774\ub904\uc9c0\uc9c0 \uc54a\uc740 \uc810\uc740 \ubb38\uc81c\uc9c0\ub9cc \uc11c\ub958 \ucc98\ub9ac\ub97c \ubabb\ud55c \uc0ac\ub78c\uc774 \ud5c8 \uad50\uc218\uac00 \ucc98\uc74c\uc740 \uc544\ub2c8\ub2e4.”\uace0 \ub9d0\ud588\ub2e4. \ud5c8 \uad50\uc218\uc758 \uc5f0\uad6c\uc5d0 \uc758\ud559\uc801 \uc131\uacfc\uac00 \uc544\uc8fc \uc5c6\uc9c0\ub294 \uc54a\ub2e4\uace0 \ucde8\uc9c0\ub2e4.<\/p>\n \uadf8\ub294 \u201c\ubd84\uba85 \uc758\ud559\uc801\uc73c\ub85c \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ubaa8\uc790\uc774\uc2dc\uc998(\ud55c \uac1c\uccb4\uc5d0 \ub458 \uc774\uc0c1\uc758 \uc720\uc804\uc790\ud615\uc774 \uc11e\uc774\ub294 \ud604\uc0c1)\uacfc, \uc758\ub3c4\ud558\uc9c0 \uc54a\uc740 \ubd80\ubd84\uc744 \uc218\uc815\ud558\ub294 \uc624\ub958\uc778 \u2018\uc624\ud504\ud0c0\uae43(off<\/span>\u00a0target<\/span>)\u2019 \ud604\uc0c1\uc774 \ubd84\uba85 \ub098\ud0c0\ub0a0 \uac83\uc774\ub2e4”\ub77c\uba70 “(\ud558\uc9c0\ub9cc) \uc6b0\ub9ac\uac00 \ubc29\uc0ac\uc120\uc758 \uc601\ud5a5\uc774 0\uc774 \ub418\uae38 \uae30\ub2e4\ub838\ub2e4\uac00\u00a0PET<\/span>\ub098 X\uc120 \ucd2c\uc601\uc744 \ud558\ub294 \uac83\uc740 \uc544\ub2c8\uc9c0 \uc54a\ub294\uac00?\u201d\ub77c\uace0 \ubc18\ubb38\ud588\ub2e4. \uadf8\ub294 \u201c\uc218\uc2ed \ub9c8\ub9ac \ub3fc\uc9c0\uc640 \uc950\ub97c \ub300\uc0c1\uc73c\ub85c \uc2e4\ud5d8\ud588\uace0 \uc624\ud504\ud0c0\uae43 \ud604\uc0c1\uc774 \ub3d9\ubb3c\uc774\ub098 \uc138\ud3ec\uc5d0 \ubb38\uc81c\ub97c \uc77c\uc73c\ucf30\ub2e4\ub294 \uc99d\uac70\ub294 \uc5c6\uc5c8\ub2e4\u201d\uace0 \ub367\ubd99\uc600\ub2e4. \ud5c8 \uad50\uc218\uac00 \uc5f0\uad6c \uacfc\uc815\uc774 \ubd88\ud22c\uba85\ud588\uace0 \uacfc\ud559\uacc4\uc5d0 \uc5f0\uad6c \uc758\ub3c4\ub97c \uc880\ub354 \ubd84\uba85\ud788 \ubc1d\ud614\uc5b4\uc57c \ud588\ub2e4\ub294 \ube44\ud310\uc5d0 \ub300\ud574\uc11c\ub294 \u201c\uc815\ub2f9\ud55c \ube44\ud310\u201d\uc774\ub77c\uba74\uc11c\ub3c4 \u201c\uc544\uae30\uc758 \uac74\uac15\uc5d0 \ub300\ud574 \uc880\ub354 \ucd08\uc810\uc744 \ub9de\ucdb0\uc57c \ud55c\ub2e4\u201d\uba70 \uc5ed\uc2dc \uc720\ubcf4\uc801\uc778 \uc785\uc7a5\uc744 \ud45c\ud588\ub2e4.<\/p>\n <\/p>\n <\/p>\n \uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~<\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n The CRISPR-Cas9 gene-editing tool is loaded into a pipette.\u00a0<\/span>Credit: Mark Schiefelbein\/AP\/Shutterstock<\/p>\n<\/figcaption><\/figure>\n <\/p>\n The meeting at which He Jiankui\u00a0explained his extraordinary claim<\/a>\u00a0to have helped produce the first babies \u2014 twin girls \u2014 born with edited genomes came to a close with a statement that came down hard on the scientist.<\/p>\n \u201cWe heard an unexpected and deeply disturbing claim that human embryos had been edited and implanted, resulting in a pregnancy and the birth of twins,\u201d reads the statement released by the organizing committee of the Second International Summit on Human Genome Editing in Hong Kong on 29 November. \u201cEven if the modifications are verified, the procedure was irresponsible and failed to conform with international norms.”<\/p>\n Similar criticism has rained down since the\u00a0revelation earlier this week<\/a>that He had used the CRISPR\u2013Cas9 genome-editing technique to modify the\u00a0CCR5<\/i>\u00a0gene in two embryos, which he then implanted in a woman. The gene encodes a protein that some common strains of HIV use to infect immune cells.<\/p>\n As researchers take stock of the week\u2019s events,\u00a0Nature<\/i>\u00a0summarizes six big questions that are still unanswered.<\/p>\n <\/p>\n On 27 November, a day before He gave his talk at the summit, China\u2019s national health ministry called on the government of Guangdong \u2014 where He\u2019s university, the Southern University of Science and Technology is \u2014 to investigate He. Two days later, the science ministry ordered him to stop doing any science; He had already said the experiments were on hold. How the Guangdong investigation will proceed is not clear. He is accused of transgressing a 2003 health-ministry guideline, which is not a law and has no clear penalties attached to it.<\/p>\n Whether He\u2019s university will take any action against him is also unclear. A university spokesperson told\u00a0Nature<\/i>\u00a0that he \u201ccannot disclose such information at this moment\u201d and to wait for official statements \u201cat an appropriate time.\u201d He has been on leave since February 2018 and this is scheduled to last until January 2021; this week, the university criticized his claims and distanced itself from his work.<\/p>\n On 27 November, the laboratory web page hosted by the university \u2014 to which He has been referring people for information about the gene-edited babies \u2014 went down, although\u00a0another site for He\u2019s lab<\/a>\u00a0remains. Several statements praising He Jiankui\u2019s accomplishments have also disappeared from government sites. A post on the science ministry\u2019s site describing a genomic-sequencing technology that He developed, and a post praising He\u2019s genomic sequencing technology on the website of the Thousand Talents Plan \u2014 a\u00a0prestigious scheme<\/a>\u00a0to\u00a0bring leading academics back to China<\/a>\u00a0\u2014 are both now inaccessible. It’s not clear if these actions are related to the week’s events, but both posts were still accessible until recently.<\/p>\n He went back to Shenzhen, where he lives, after his talk at the summit, according to a statement provided by He’s spokesperson, Ryan Ferrell, and missed a planned appearance at the summit on 29 November. \u201cI have returned to Shenzhen and will not attend the conference on Thursday. I will remain in China, my home country, and cooperate fully with all inquiries about my work,\u201d the statement said.<\/p>\n <\/p>\n Many scientists have said that an independent body should confirm He’s scientific claims by performing an in-depth comparison of the parents\u2019 and children\u2019s genes. The problem is, almost everyone agrees that the babies and their parents should remain anonymous.<\/p>\n \u201cHe has kept them secret, and for good reasons,\u201d says Nobel-prizewinning biologist David Baltimore, chair of the summit’s organizing committee and former president of the California Institute of Technology in Pasadena. \u201cWe haven\u2019t even laid out how that independent investigation will happen.\u201d<\/p>\n He’s team could supply anonymized samples. Outside scientists could also visit He’s laboratory to analyse the data. In a statement released by his spokesperson, He said that he will invite other researchers to do an independent investigation. \u201cMy raw data will be made available for third-party review.”<\/p>\n He also says that he has submitted studies on his human gene-editing research to journals for publication. He has told some scientists that a paper will be published by the end of the year, but has not specified in which journal. But even if this happens, strict Chinese genetic-resources laws would prevent He from publishing the gene sequences of the parents or the children, and without those, scientists would have a difficult time verifying his claims.<\/p>\n <\/p>\n In the absence of a peer-reviewed publication or preprint describing He\u2019s gene-editing work, some scientists are parsing his presentation to try and understand how the twins’ genomes were edited \u2014 and any potential consequences of these changes.<\/p>\n Gaetan Burgio, a geneticist at Australia National University in Canberra who works on CRISPR gene editing, says that the raw sequencing data that He presented in his talk suggests that the babies\u2019 cells harbour multiple edited versions of the\u00a0CCR5<\/i>\u00a0gene, with different-sized DNA deletions. Such \u2018mosaicism\u2019 can be caused when CRISPR edits some early embryo cells differently to others, or fails to edit some. Other researchers have reported mosaicism in efforts to edit human embryos for research purposes.<\/p>\n RNA researcher Sean Ryder, at the University of Massachusetts Medical School in Worcester, pointed out additional concerns in a\u00a0Twitter post.<\/a><\/p>\n He Jiankui told the gene-editing conference that he targeted the\u00a0CCR5<\/i>gene because some people naturally carry a mutation in\u00a0CCR5<\/i>\u00a0\u2014 a 32-DNA-letter deletion known as delta-32 \u2014 that inactivates the gene. But Ryder says that that the\u00a0CCR5<\/i>\u00a0deletions that He claimed to introduce into the babies\u2019 cells by CRISPR gene editing are not identical to the delta-32 mutation. \u201cThe point is that none of the three match the well-studied delta 32 mutation, and as far as I can tell, none have been studied in animal models. Unconscionable,\u201d Ryder wrote in the post.<\/p>\n <\/p>\n He Jiankui claims to have helped produce the first babies born with edited genomes.<\/span>Credit: TPG via Zuma<\/p>\n <\/p>\n<\/figcaption><\/figure>\n As Jennifer Doudna, a pioneer of the CRISPR-Cas9 genome-editing tool, listened to He present his work at the summit, one idea kept coming back to her. \u201cThe thought I kept having was the potential for rogue scientists to use this in unethical ways. It\u2019s a real risk,\u201d says Doudna, a biochemist at the University of California, Berkeley,<\/p>\n Before He\u2019s revelations, many scientists were already worried about the prospect that someone was on the brink of creating a gene-edited person. Biologist George Daley, dean of Harvard Medical School in Boston, Massachusetts, and a member of the summit’s organizing committee, pointed to a procedure that replaces diseased mitochondrial DNA in an embryo with healthy mitochondrial DNA from another person, eliminating the embryo’s original disease-causing mutation. Although mitochondrial-replacement therapy lacks the approval of the biomedical community or the US Food and Drug Administration (FDA), doctors based in New York City used it to\u00a0produce a baby in Mexico in 2016<\/a>. \u201cSimilar premature practice of embryo editing by CRISPR-Cas9 is likely despite our calls for caution,\u201d Daley said.<\/p>\n At the Hong Kong summit, scientists discussed whether another announcement of human-germline editing \u2014 the modification of genes passed on to future generations \u2014 is nigh. \u201cWe do have reason to be concerned,\u201d said Baltimore. \u201cIf anyone working in the field gets indications that it is happening, it is important they let authorities know.\u201d<\/p>\n <\/p>\n Many researchers fear that He’s revelations could hamper the future of germline editing. \u201cIn the US some are suggesting draconian bans, which is antithetical to goals of science,\u201d says Baltimore.<\/p>\n In the wake of the revelations, FDA Commissioner Scott Gottlieb made comments that raised concerns among scientists. \u201cGovernments will now have to react,\u201d he\u00a0told the news site BioCentury<\/a>. And on 28 November, the US National Institutes of Health (NIH) director Francis Collins said in a statement that \u201cthe need for development of binding international consensus on setting limits for this kind of research, now being debated in Hong Kong, has never been more apparent.\u201d<\/p>\n The statement released at the summit\u2019s close makes a plea to keep open a path for safely translating gene-editing technology into treatments: \u201cGermline genome editing could become acceptable in the future if these risks are addressed.\u201d<\/p>\n But the debacle has focused worldwide interest on germline genome editing and fears of a chilling effect may be overstated. \u201cThere might be some women excited by the possibility of taking part in this research,\u201d said Judith Daar, at the University of California Irvine School of Medicine and School of Law, at a summit satellite session when asked whether the controversy might dissuade women from donating eggs for research in the future. \u201cThe instinct is to say this is a debacle and could suppress participation. But I\u2019m always amazed by the diverse reactions,” she added.<\/p>\n <\/p>\n \u201cWe don\u2019t have a blueprint, but we have been asking academies,\u201d said Baltimore. \u201cIt is a challenge to the world.\u201d<\/p>\n The statement released by the summit’s organizing committee suggests that science academies around the world make recommendations to their own governments, while coordinating with each other.<\/p>\n It also suggests the creation of an international forum that would funnel research and clinical trials through an international registry, and discuss issues such as equitable access to the benefits of gene editing. But genome editing in human embryos potentially has an unwieldy range of users, and that could make maintaining such an organization difficult. \u201cVirtually every lab doing molecular biology is using this technique,\u201d said Daley.<\/p>\n The committee also suggested the need for a \u201ctranslational pathway\u201d that would provide a rigorous and responsible way for researchers to take germline gene editing to the clinic. Organizing-committee member Alta Charo, a bioethicist at the University of Wisconsin Law School in Madison, said expectations have to be realistic. \u201cYou can\u2019t expect perfection. What you can do is try to minimize these incidents with enforcements that punish rogue behaviour.\u201d<\/p>\n The next human genome-editing summit will take place in London in 2021.<\/p>\n <\/p>\n <\/p>\n \uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~<\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n [\uc694\uc57d]\uc911\uad6d\uc758 \ud55c \uacfc\ud559\uc790\uac00 \ubc30\uc544\uc758 \uc720\uc804\uc790\ub97c \uad50\uc815\ud55c \ub4a4 \uc774\ub97c \uc790\uad81\uc5d0 \ucc29\uc0c1\uc2dc\ucf1c \uc30d\ub465\uc774\ub97c \ud0dc\uc5b4\ub098\uac8c \ud558\ub294\ub370 \uc131\uacf5\ud574 \ub17c\ub780\uc774 \ub418\uace0 \uc788\ub2e4. \uc2a4\ud0e0\ud37c\ub4dc\ub300 \ubc95\ud559\uacfc \uad50\uc218\uc774\uc790 \uc0dd\uba85\uc724\ub9ac \uc804\ubb38\uac00\uc778 \ud589\ud06c \uadf8\ub9b4\ub9ac \uad50\uc218\ub294 “\uc774\ubc88 \uc2dc\uc220\uc740 \ubd88\ubc95\uc774\uba70 \ub610\ud55c \ub450 \uc544\uc774\uac00 \uc548\uc804\ud558\ub2e4\uace0 \ub2f4\ubcf4\ud560 \uc218 \uc5c6\ub294 \uc0c1\ud669”\uc774\ub77c\uace0 \uc9c0\uc801\ud588\ub2e4.\u00a0(2018.12)<\/p>\n <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n <\/p>\n \uc9c0\ub09c\ub2ec \uc911\uad6d\ub0a8\ubc29\ub300 \uacfc\ud559\uc790 \ud5c8\uc820\ucfe0\uc774\ub294 \uc138\uacc4 \ucd5c\ucd08\ub85c \uc720\uc804\uc790\ub97c \uad50\uc815\ud55c \uc544\uae30\uac00 \ud0dc\uc5b4\ub0ac\ub2e4\uace0 \ubc1d\ud614\ub2e4. \uc774 \uc544\uae30\ub294 \uc5d0\uc774\uc988\ub97c \uc720\ubc1c\ud558\ub294 ‘\uc778\uac04\uba74\uc5ed\uacb0\ud54d\ubc14\uc774\ub7ec\uc2a4(HIV)’ \uac10\uc5fc \uc704\ud5d8\uc744 \uc904\uc774\ub3c4\ub85d DNA\uac00 \uad50\uc815\ub410\ub2e4. \ud5c8\uc820\ucfe0\uc774\uc758 \uc8fc\uc7a5\uc740 \uc544\uc9c1 \ud655\uc778\ub418\uc9c0 \uc54a\uc558\ub2e4. \uc911\uad6d \ub2f9\uad6d\uc740 \uc870\uc0ac\uc5d0 \ucc29\uc218\ud588\uace0 \uad00\ub828 \uc5f0\uad6c\ub97c \uc911\uc9c0\ud558\ub77c\uace0 \ubc1d\ud614\ub2e4. \uc774\uc5b4\uc9c0\ub294 \ud1a0\ub860\uc5d0\uc11c \ubbf8\uad6d \uc2a4\ud0e0\ud37c\ub4dc\ub300 \ubc95\ud559\uacfc\uc5d0\uc11c \uc0c8\ub85c\uc6b4 \uc0dd\uba85\uc758\ub8cc \uae30\uc220\uc758 \uc724\ub9ac\ud559, \ubc95\ud559 \ubc0f\u00a0 \ud68c\uc801 \uc758\ubbf8\uc5d0 \ub300\ud574 \uc5f0\uad6c\ud558\ub294 \ud589\ud06c \uadf8\ub9b4\ub9ac \uad50\uc218\ub294 \uc720\uc804\uc790 \uad50\uc815\uc744 \ub458\ub7ec\uc2fc \uc724\ub9ac\uc801\uc778 \ubb38\uc81c\uc5d0 \ub300\ud574\uc11c \uc774\uc57c\uae30\ud55c\ub2e4.<\/p>\n <\/p>\n \u25c6\u00a0 \uba3c\uc800 \uc911\uad6d \ud5c8\uc820\ucfe0\uc774 \ubc15\uc0ac\uac00 \ud55c \uc77c\uc744 \uc124\uba85\ud574\uc8fc\uc138\uc694<\/p>\n \ub098\ub294 \uadf8\uac00 \ud588\ub2e4\uace0 \ud55c \uc77c\uc5d0 \ub300\ud574\uc11c \uc124\uba85\ud560 \uc218 \uc788\ub2e4. \ud558\uc9c0\ub9cc \ud5c8\uc820\ucfe0\uc774 \ubc15\uc0ac\uac00 \uc720\ud22c\ube0c\ub97c \ud1b5\ud574\uc11c \uc774\uc57c\uae30\ud55c \uac83 \ub9d0\uace0\ub294 \uc5b4\ub5a4 \uc77c\uc744 \ud588\ub294\uc9c0 \ubaa8\ub974\uaca0\ub2e4. \uadf8\uac00 \uc720\uc804\uc790\ub97c \uad50\uc815\ud588\ub2e4\ub294 \uac83\uacfc \ud568\uaed8 \uc720\uc804\uc790\uac00 \uad50\uc815\ub41c \uc544\uae30\uac00 \uc874\uc7ac\ud55c\ub2e4\ub294 \ub3c5\ub9bd\uc801\uc778 \uc99d\uac70\ub294 \uc544\uc9c1 \uc5c6\ub2e4. \uc774\uac83\uc740 \ub300\ub2e8\ud55c \uc0ac\uae30\uc77c \uc218 \uc788\ub2e4. \uc774\uac19\uc740 \ub300\ub2f4\ud55c \uc0ac\uae30\ub294 \uacfc\uac70 2004~2005\ub144 \ud669\uc6b0\uc11d \ubc15\uc0ac\uac00 \uc778\uac04 \ubc30\uc544\uc904\uae30\uc138\ud3ec \ubcf5\uc81c\uc5d0 \uc131\uacf5\ud588\ub2e4\uace0 \ubc1c\ud45c\ud55c \uac70\uc9d3 \uc8fc\uc7a5 \ub4f1 \uc0dd\uba85\uacfc\ud559\ubd84\uc57c\uc5d0\uc11c \uc788\uc5b4\uc654\ub2e4. <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n \uc720\uc804\uc790 \uac00\uc704\ub294 DNA \uc5fc\uae30 \uc77c\ubd80\ub97c \uc815\uad50\ud558\uac8c \uc790\ub97c \uc218 \uc788\ub294 \uae30\uc220\uc744 \ub73b\ud55c\ub2e4. 2012\ub144 3\uc138\ub300 \uc720\uc804\uc790 \uac00\uc704\uc778 \ud06c\ub9ac\uc2a4\ud37c \uce74\uc2a49\uc758 \ub4f1\uc7a5\uc774\ud6c4 \ub9ce\uc740 \uacfc\ud559\uc790\ub4e4\uc774 \ub3d9\uc2dd\ubb3c\uc5d0\uc11c \uc720\uc804\uc790 \uc5fc\uae30 \uc11c\uc5f4\uc744 \ubc14\uafb8\ub294 \uc2e4\ud5d8\uc5d0 \uc131\uacf5\ud588\ub2e4. <\uc0ac\uc9c4\uc81c\uacf5=\ub124\uc774\ucc98><\/span><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n \u25c6\u00a0 \uc774\uac83\uc740 \ubbf8\uad6d\uc5d0\uc11c \ud569\ubc95\uc778\uac00? \uadf8\ub807\uc9c0 \uc54a\ub2e4\uba74 \uc774\uc720\ub294 \ubb54\uac00.<\/p>\n \uc774\uac83\uc740 \ubbf8\uad6d\uc5d0\uc11c \ud569\ubc95\uc774 \uc544\ub2c8\ub2e4. \ub0b4 \uc0dd\uac01\uc5d0 \ubbf8\uad6d\uc2dd\ud488\uc758\uc57d\uad6d(FDA)\uc740 \ubc95\uc6d0\uc774 \uc720\uc9c0\ud560 \uac83\uc73c\ub85c \ubcf4\uc774\ub294 \uc785\uc7a5\uc744 \ucde8\ud560 \uac83\uc774\ub2e4. \uc720\uc804\uc801\uc73c\ub85c \ubcc0\ud615\ub41c \uc778\uac04 \ubc30\uc544\ub294 \uc57d\ubb3c\uc774\ub098 \uc0dd\ubb3c\ud559\uc801 \uc81c\ud488\uc774\uba70 \ubc95\uc6d0\uc758 \uad00\ud560 \uc544\ub798 \uc874\uc7ac\ud55c\ub2e4. \uc0c8\ub85c\uc6b4 \uc57d\uc744 FDA\uc2b9\uc778 \uc5c6\uc774 \ubc30\ud3ec\ud558\ub294 \uac83\uc740 \ubd88\ubc95(\uc5f0\ubc29\ubc94\uc8c4)\uc5d0 \ud574\ub2f9\ud55c\ub2e4. \uc5f0\uad6c\ubaa9\uc801\uc73c\ub85c FDA \uc2b9\uc778\uc740 \uc27d\uac8c \ubc1b\uc744 \uc218 \uc788\ub2e4. \ub2f9\uc2e0\uc740 FDA\uc5d0 ‘\uc5f0\uad6c\uc6a9 \uc2e0\uc57d’ \uba74\uc81c\ub97c \uc704\ud55c \uc2e0\uccad\uc11c\ub97c \uc81c\ucd9c\ud574\uc57c \ud55c\ub2e4. \ub610\ud55c \ub2f9\uc2e0\uc740 FDA\uc5d0 \uc774 \uc2e4\ud5d8\uc740 \uc88b\uc740 \ubaa9\uc801\uc774\uba70 \uc2e4\ud5d8 \ucc38\uac00\uc790\ub4e4\uc5d0\uac8c \uc704\ud5d8\ud558\uc9c0 \uc54a\uc73c\uba70 \uc2e4\ud5d8\uc774 \ud6a8\uacfc\uc801\uc77c \uac83\uc774\ub77c\ub294 \ud569\ub9ac\uc801\uc778 \uc99d\uac70\ub97c \uc81c\ucd9c\ud574\uc57c\ub9cc \ud55c\ub2e4. \ud5c8\uc820\ucfe0\uc774 \ubc15\uc0ac\uc758 \uc774\ubc88 \uc77c\uc740 \uc5b4\ub290\ucabd\ub3c4 \ub9cc\uc871\uc2dc\ud0a4\uc9c0 \ubabb\ud588\ub2e4. \ub530\ub77c\uc11c \uc5f0\uad6c\uc6a9 \uc2e0\uc57d \ud5c8\uac00\ub3c4 \ubc1b\uc9c0 \ubabb\ud560 \uac83\uc774\ub2e4. \uadf8\ub7ec\ub098 2015\ub144 12\uc6d4 \uc774\ud6c4 \uc758\ud68c\ub294 \uc815\uae30\uc801\uc73c\ub85c FDA\uc758 \uc790\uae08\uc870\ub2ec \ubc95\uc548\uc5d0 \uac1c\uc815\uc548\uc744 \ucd94\uac00\ud574 \uc5b4\ub5a4 \uacc4\uc5f4\uc758 \uc778\uac04 \uc0dd\uc2dd\uc138\ud3ec\uc5d0 \ub300\ud55c \uc720\uc804\uc790 \uad50\uc815\uc744 \uae08\uc9c0\ud558\uace0 \uc788\ub2e4. \ub530\ub77c\uc11c \ub9cc\uc57d \ub2f9\uc2e0\uc774 \ud5c8\uc820\ucfe0\uc774 \ubc15\uc0ac\uac00 \ud55c \uc2e4\ud5d8\uc744 \ubbf8\uad6d\uc5d0\uc11c \ud588\ub2e4\uba74 FDA\uc758 \uc2b9\uc778 \uc5c6\uc774 \ud588\uc744 \uac83\uc774\uace0 \uc2e0\uc57d\uc744 \ubd88\ubc95\uc801\uc73c\ub85c \uc720\ud1b5\uc2dc\ud0a4\ub294 \uac83\uacfc \uac19\uc740 \uc0c1\ud669\uc774 \ub41c\ub2e4. \ub2e4\ub978 \uc5ec\ub7ec \ub098\ub77c\uc5d0\uc11c\ub3c4, \ud2b9\ud788 \uc720\ub7fd\uc5d0\uc11c\ub294 \ud2b9\uc815 \ubc95\ub839\uc5d0 \uc758\ud574 \uc778\uac04 \uc0dd\uc2dd\uacc4\uc5f4 \uc138\ud3ec\uc758 \uc720\uc804\uc790\ub97c \uad50\uc815\ud558\ub294 \uac83\uc740 \ubd88\ubc95\uc774\ub2e4. \uc774\uac19\uc740 \ubc95\uc774 \uc5c6\ub294 \ub098\ub77c\uc5d0\uc11c\ub294 \ud569\ubc95\uc77c \uc218 \uc788\ub2e4(\uc801\uc5b4\ub3c4 \ubd88\ubc95\uc774 \uc544\ub2d0 \uc218 \uc788\ub2e4).<\/p>\n <\/p>\n \u25c6 \uc704\ud5d8\uc740 \ubb34\uc5c7\uc778\uac00? \uc7a0\uc7ac\uc801\uc778 \uc774\ub4dd\uc740 \ubb34\uc5c7\uc778\uac00<\/p>\n \uc544\uc774\ub4e4\uc5d0\uac8c \uc788\uc5b4\uc11c \ud06c\ub9ac\uc2a4\ud37c \uc720\uc804\uc790 \uac00\uc704\uac00 \uac16\uace0 \uc788\ub294 \uc704\ud5d8\uc131\uc740 \ub2e4\ub978 \ubd80\ubd84\uc758 DNA\ub97c \uc190\uc0c1\uc2dc\ud0ac \uc218 \uc788\ub2e4\ub294 \uc810\uc774\ub2e4. \uc774\ub97c ‘\uc624\ud504 \ud0c0\uac9f \ud6a8\uacfc’\ub77c\uace0 \ubd80\ub978\ub2e4. \uc774\ub294 \uc720\uc804\uc790 \uac00\uc704\ub97c \uc0ac\uc6a9\ud560 \ub54c \uc0c1\ub2f9\ud788 \uc77c\ubc18\uc801\uc73c\ub85c \ub098\ud0c0\ub09c\ub2e4. \uc720\uc804\uccb4\uc758 \ub2e4\ub978 \ubd80\ubd84\uc774 \ubcc0\ud558\ub294 \uac83\uacfc \ud568\uaed8 \ud5c8\uc820\ucfe0\uc774 \ubc15\uc0ac\ub294 \uadf8\uac00 \ubaa9\ud45c\ub85c \ud588\ub358 CCR \uc720\uc804\uc790\ub97c \uc815\ud655\ud558\uac8c \ubc14\uafb8\uc9c0 \ubabb\ud588\ub2e4. \ub610\ud55c \ud5c8\uc820\ucfe0\uc774\uac00 \uc218\uc815\ud55c \uc720\uc804\uc790\ub294 HIV\ub97c \ub9c9\ub294\ub370 \ud6a8\uacfc\uc801\uc774\uc9c0 \uc54a\uc744\uc218\ub3c4 \uc788\uace0 \ud574\ub85c\uc6b8 \uc218\ub3c4 \uc788\ub2e4. <\/p>\n \u25c6 \uc774\uac83\uc774 \uc5b8\uc81c \ud569\ubc95\ud654 \ub420\uae4c<\/p>\n FDA\uac00 \uc774\uac83\uc744 \uc9c4\ud589\ud560 \uc218 \uc788\uc744 \ub9cc\ud07c \uc548\uc804\uc131\uc774 \ud655\ubcf4\ub410\ub2e4\uace0 \uc0dd\uac01\ud558\uba74 \uc9c4\ud589\ub420 \uc218 \uc788\ub2e4. \ud558\uc9c0\ub9cc \ub09c \uc774\uac83\uc774 \uace7 \uc77c\uc5b4\ub0a0 \uac83\uc774\ub77c\uace0 \ubcf4\uc9c0 \uc54a\ub294\ub2e4.<\/p>\n <\/p>\n \u25c6\u00a0 \uc774\uac83\uc740 \uad6d\uc81c\uae30\uad6c\uc5d0 \uc758\ud574\uc11c \ud1b5\uc81c \uac00\ub2a5\ud55c\uac00. \uc5b4\ub5bb\uac8c \uaddc\uc81c\ub418\uc5b4\uc57c \ud558\ub294\uac00<\/p>\n \ubbf8\uad6d\uc5d0\uc11c\ub294 FDA\uc640 IRB\uc5d0 \uc758\ud574 \uac10\ub3c5\ub41c\ub2e4. \uc644\ubcbd\ud558\uc9c0\ub294 \uc54a\uc9c0\ub9cc \uadf8\ub807\ub2e4\uace0 \ub054\ucc0d\ud55c \uac83\uc740 \uc544\ub2c8\ub2e4.<\/p>\n <\/p>\n \u25c6\u00a0 \ud569\ubc95\ud654 \ub418\uba74 \uc6b0\ub9ac\uac00 \ub9c8\uc8fc\ud558\uac8c \ub420 \uc724\ub9ac\uc801 \ubb38\uc81c\ub294 \ubb34\uc5c7\uc778\uac00<\/p>\n \uc544\uc774\ub4e4\uc758 \uc548\uc804 \ubb38\uc81c\uac00 \ud575\uc2ec\uc774\ub2e4. \uadf8\uac83 \ub9d0\uace0\ub3c4 \uc778\uac04 \uc720\uc804\ud559\uc5d0 \ub300\ud55c \uc778\ub958\uc758 \uc9c0\uc2dd\uc5d0 \ube44\ucd94\uc5b4\ubcfc \ub54c \ubc30\uc544\uc758 \uc720\uc804\uc790 \uad50\uc815\uc774 \ubc30\uc544 \uc120\ud0dd\ubcf4\ub2e4 \ub0ab\ub2e4\uace0 \ubcfc \uc218 \uc788\ub294 \uc810\uc740 \uac70\uc758 \uc5c6\ub2e4. \uc6b0\ub9ac\ub294 ‘\uc288\ud37c \uc544\uae30’\ub97c \ub9cc\ub4e4\ub9cc\ud07c \ub9ce\uc740 \uac83\uc744 \uc54c\uc9c0 \ubabb\ud558\uace0 \uc870\ub9cc\uac04 \uc774\ub7f0 \uc77c\uc774 \ubc1c\uc0dd\ud560 \uac83 \uac19\uc9c0\ub3c4 \uc54a\ub2e4. \ubbf8\ub798 \uc138\ub300\ub85c \uc804\ud574\uc9c8 \uc218 \uc788\ub294 \uc720\uc804\uc790 \uad50\uc815, \ud3b8\uc9d1\uc774 \uc5b4\ub5a4 \uc0ac\ub78c\ub4e4\uc5d0\uac8c\ub294 \uc815\ub9d0 \ud070 \uc724\ub9ac\uc801\uc778 \ubb38\uc81c\uac00 \ub420 \uac83\uc774\ub2e4. \uc774\uac83\uc740 ‘\uae30\uc900\uc120’\uc774\ub2e4. \uc6b0\ub9ac\ub294 \uc774\ub97c \ub118\uc5b4\uac00\uba74 \uc548\ub41c\ub2e4.<\/p>\n <\/p>\n \u25c6\u00a0 \uc5b4\ub5a4 \ubc95\uc801 \ubb38\uc81c\ub97c \uc608\uc0c1\ud558\ub098<\/p>\n \ub9cc\uc57d \uc774\uac83\uc744 \ud569\ubc95\ud654\ub418\uae30 \uc804\uc5d0 \uc2dc\ub3c4\ud55c\ub2e4\uba74 \uc784\uc0c1\uc758\ud559, \uacfc\ud559\uc790\ub4e4\uc5d0\uac8c \uc5f0\ubc29\ubc94\uc8c4 \ud610\uc758\uac00 \uc608\uc0c1\ub41c\ub2e4. \uc720\uc804\uc790\uac00 \ubcc0\ud615\ub41c \uc778\uac04 \ubc30\uc544\uac00 FDA\ubc95\uc0c1 \uc2e0\uc57d\uc778\uc9c0, \uc758\ub8cc\uae30\uae30\uc778\uc9c0\uc5d0 \ub300\ud55c \uc758\ubb38\uc774 \uc0dd\uae38 \uc218 \uc788\ub2e4. \ub9cc\uc57d \uc774\uac83\uc774 \ud569\ubc95\uc774 \ub418\uace0 \ub09c \ub4a4 \uc2dc\ud589\ud588\ub294\ub370 \uc798\ubabb\ub410\ub2e4\uba74 \ud070 \uc758\ub8cc\uacfc\uc2e4 \uc18c\uc1a1\uc73c\ub85c \uc774\uc5b4\uc9c8 \uc218 \uc788\ub2e4.<\/p>\n <\/p>\n **\ud5c8\uc820\ucfe0\uc774 \ubc15\uc0ac\ub294 \uc2a4\ud0e0\ud37c\ub4dc\ub300 \uc2a4\ud14c\ud310 \ud018\uc774\ud06c \uad50\uc218 \uc5f0\uad6c\uc2e4\uc5d0\uc11c 2011~2012\ub144 \ubc15\uc0ac\ud6c4\uc5f0\uad6c\uc6d0\uc73c\ub85c \uc788\uc5c8\ub2e4. \ud018\uc774\ud06c \uad50\uc218 \uc5f0\uad6c\uc2e4\uc5d0\uc11c \ud5c8\uc820\ucfe0\uc774 \ubc15\uc0ac\ub294 \ucef4\ud4e8\ud130 \ubd84\uc11d\uacfc \uad00\ub828\ub41c \uc5f0\uad6c\ub97c \ud588\uc73c\uba70 \uc774\ub294 \uc720\uc804\uc790 \uad50\uc815\uacfc \uad00\ub828\ub41c \uc77c\uc740 \uc544\ub2c8\uc5c8\ub2e4.<\/p>\n <\/p>\n <\/p>\n (\uc6d0\ubb38<\/a>)<\/p>\n <\/p>\n <\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n \uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~<\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n <\/p>\n Errors in techniques for tracking down genetic mutations led to erroneous results in a now-retracted study.<\/span>Credit: Getty<\/p>\n <\/p>\n <\/p>\n<\/figcaption><\/figure>\n A study that\u00a0raised questions over the future health<\/a>\u00a0of the\u00a0world\u2019s first gene-edited babies<\/a>\u00a0has been retracted because of key errors that undermined its conclusion.<\/p>\n The research, published in June 2019 in\u00a0Nature Medicine<\/i>1<\/a><\/sup>, had suggested that people with two copies of a natural genetic mutation that confers HIV resistance are at an\u00a0increased risk of dying earlier than other people<\/a>. It was conducted in the wake of\u00a0controversial experiments by the Chinese scientist He Jiankui<\/a>, who had attempted to recreate the effects of this mutation in the gene\u00a0CCR5<\/i>\u00a0by using the CRISPR gene-editing tool in human embryos. The twin girls born last year as a result of the work did not end up carrying this exact mutation, but the research attracted attention because of its potential relevance to such experiments.<\/p>\n But a flurry of studies2<\/a><\/sup>,<\/sup>3<\/a><\/sup>,<\/sup>4<\/a><\/sup>\u00a0that looked anew the\u00a0Nature Medicine<\/i>\u00a0research \u2014 some of which analysed new data from genome databases comprising sequences from hundreds of thousands of people \u2014 have rejected the results and find no evidence that people with the mutation die early. The erroneous conclusion about\u00a0CCR5<\/i>\u00a0was caused by technical errors in how the mutation was identified in a population-health database.<\/p>\n \u201cI feel I have a responsibility to put the record straight for the public,\u201d says\u00a0<\/b>Rasmus Nielsen, a population geneticist at the University of California, Berkeley, who led study, which the authors retracted on 8 October. Nielsen also co-authored one of the papers rebutting its findings.<\/p>\n Some researchers stress that\u00a0because the twins did not receive exactly the same mutation that occurs naturally<\/a>, the original research and its retraction would not necessarily offer insights into their health anyway. But the episode raises questions about how best to assess the safety of future attempts to edit genes in human embryos.<\/p>\n <\/p>\n CRISPR concern<\/strong><\/p>\n He Jiankui shocked the scientific world when he announced, in November 2018,\u00a0that his team had used CRISPR to disable the\u00a0CCR5<\/i>\u00a0gene in two babies born that month<\/a>. He, who was at the time a biophysicist at the Southern University of China in Shenzhen, said he chose to target\u00a0CCR5<\/i>\u00a0because people with a 32-DNA letter deletion known as delta-32 in the gene are resistant to HIV but seem not to experience significant related health problems.<\/p>\n He has not published data supporting his work, but his announcement \u2014 presented at a scientific meeting \u2014 indicated that, for one of the twins, both copies of\u00a0CCR5<\/i>\u00a0were altered, whereas the other twin\u00a0carried edits in just one of her two copies<\/a>. None of the changes exactly matched the delta-32 variation.<\/p>\n Research has hinted that the delta-32 mutation, which is relatively common in people of European ancestry, might carry downsides \u2014 one small study5<\/a><\/sup>\u00a0found that carriers were more likely than other people to die from influenza. To tackle the question in larger data sets, Nielsen and his Berkeley colleague Xinzhu Wei looked at the UK Biobank, a database containing genome and health data from 500,000 British people.<\/p>\n Their\u00a0Nature Medicine<\/i>\u00a0paper1<\/a><\/sup>\u00a0reported that people with two copies of delta-32 \u2014 whom they estimated to make up about 1% of biobank participants \u2014 were slightly more likely to die by the age of 76 than were those with one or no copies. They also found that the database harboured fewer people with two copies of delta-32 than evolutionary theory predicted it should \u2014 a sign that individuals with two copies were dying earlier, on average, than the population at large, Wei and Nielsen argued.<\/p>\n <\/p>\n Results not replicated<\/strong><\/p>\n Questions over the conclusion emerged as soon as the paper was published. Sean Harrison, an epidemiologist at the University of Bristol, UK, attempted to replicate the findings that night. He did not have UK Biobank data on the gene variant that Wei and Nielsen used to identify carriers of delta-32, so he analysed genetic variants near it on the genome that should have given the same result (adjacent parts of the genome tend to be inherited together, allowing scientists to infer the presence or absence of a DNA sequence by analysing neighbouring variants). When they didn\u2019t, he described his findings in a series of tweets and later a\u00a0blogpost<\/a>.<\/p>\n The discrepancy Harrison identified piqued the interest of David Reich, a population geneticist at Harvard Medical School in Boston, Massachusetts, whose lab is studying\u00a0CCR5<\/i>. Working with Nielsen, his team discovered2<\/a><\/sup>\u00a0that Neilsen and Wei\u2019s method had caused them to undercount the number of people in the UK Biobank with two copies of the delta-32 mutation, because the probe that measured the variant they were tracking did not always identify its target sequence. This \u2014 and not the supposed harmful effects of the mutation \u2014 explained the apparent absence of carriers from the UK Biobank database, says Nielsen.<\/p>\n He stresses that the undercounting problem is unique to the gene variant his team looked at, and not a general issue with UK Biobank data. \u201cThere were checks we could have done and should have done that we didn\u2019t do. We missed the fact that there was a genotyping error,\u201d Nielsen says.<\/p>\n Another follow-up study3<\/a><\/sup>, posted on a preprint server last week and based on genome databases that together include nearly 300,000 people from Iceland and Finland, also found no evidence that people with two copies of delta-32 die earlier than others.<\/p>\n <\/p>\n No green light<\/strong><\/p>\n Researchers stress that the unravelling of Wei and Nielsen\u2019s results does not mean that it is a sound idea to target\u00a0CCR5<\/i>\u00a0for gene editing. \u201cIt\u2019s very reasonable to expect that it might have a valuable function that we just don\u2019t know how to measure. It seems very unwise to edit it out,\u201d says Reich.<\/p>\n Ga\u00e9tan Burgio, a geneticist at the Australian National University in Canberra, says the original\u00a0Nature Medicine<\/i>\u00a0paper offered no insights into the health of the gene-edited twins. \u201cTherefore, the retraction and these additional studies on European populations will still have no relevance to CRISPR babies, in my view,\u201d he says. Population-based studies are very unlikely to give insights on these two babies, who don\u2019t carry the\u00a0CCR5<\/i>-delta-32 mutation, he says.<\/p>\n Nielsen hopes that his team\u2019s error does not dissuade others from using databases such as the UK Biobank to understand the effects of editing the human germ line, the DNA that can be passed on to future generations.<\/p>\n K\u00e1ri Stef\u00e1nson, head of the company deCODE genetics in Reykjavik and a co-author of one of the papers that found no evidence that delta-32 is harmful, says that Nielsen\u2019s original study was not a valuable contribution to debates over germline gene editing. But he agrees that resources such as the UK Biobank and his company\u2019s data on Iceland\u2019s population can inform future efforts. \u201cI think databases like this provide a fairly good way of assessing the probable effect of altering bases, no question about it,\u201d he says.<\/p>\n <\/p>\n <\/p>\n <\/p>\n
\n\ud559\uacc4\uc120 “\uc5f0\uad6c \uc911\ub2e8\ud558\ub77c” \uc694\uad6c\ub3c4<\/b><\/p>\n[\uc720\uc804\uc790 \ud3b8\uc9d1 \uc544\uae30 \ub17c\ub780]\uc810\uc785\uac00\uacbd ‘\uc720\uc804\uc790 \ud3b8\uc9d1 \uc544\uae30’<\/h5>\n
![\"\"](\"https:\/\/imgnews.pstatic.net\/image\/584\/2018\/12\/01\/0000002457_001_20181201090057169.jpg?type=w647\")
<\/span><\/p>\n![\"\"](\"https:\/\/imgnews.pstatic.net\/image\/584\/2018\/12\/01\/0000002457_002_20181201090057187.jpg?type=w647\")
<\/span><\/p>\n![\"\"](\"https:\/\/imgnews.pstatic.net\/image\/584\/2018\/12\/01\/0000002457_003_20181201090057237.jpg?type=w647\")
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<\/span><\/p>\nFirst CRISPR babies: six questions that remain<\/h5>\n
Startling human-genome editing claim leaves many open questions, from He Jiankui’s next move to the future of the field.<\/h6>\n
![\"Zhou](\"\/\/media.nature.com\/w800\/magazine-assets\/d41586-018-07607-3\/d41586-018-07607-3_16307016.jpg\")
<\/div>\n<\/div>1. Is He Jiankui in trouble?<\/h6>\n
2. Are He’s claims accurate?<\/h6>\n
3. How exactly did CRISPR edit the twins’ genomes?<\/h6>\n
![\"He](\"\/\/media.nature.com\/w800\/magazine-assets\/d41586-018-07607-3\/d41586-018-07607-3_16307018.jpg\")
<\/div>\n<\/div>4. When will there be another gene-edited human?<\/h6>\n
5. Will He’s revelations hamper ethical efforts to do germline editing?<\/h6>\n
6. How will scientists ensure better oversight of germline editing in future?<\/h6>\n
\uccab\ubc88\uc9f8 \uc720\uc804\uc790 \uad50\uc815 \uc544\uae30 \ucd9c\uc0b0 : \ubc95\uc801\u00b7\uc724\ub9ac\uc801 \ubb38\uc81c\uc5d0 \ub300\ud55c \uace0\ucc30<\/h5>\n
![\"\"](\"https:\/\/post-phinf.pstatic.net\/MjAxODEyMDhfMTk3\/MDAxNTQ0MjQ4OTU3NTc1.wJ_9_fms2pro54mIHUtSWL_xG48Jvl9SnoGuD8o0pVYg.LcHWeo2_kpQfMxbffz-A2EDGcxx9ze7tZ4yaGHqZ8q4g.JPEG\/%ED%97%88%EC%A0%A0%EC%BF%A0%EC%9D%B4.jpg?type=w1200\")
<\/a><\/p>\n
\n\uadf8\uac00 \ub9d0\ud55c \uac83\uc774 \uc2e4\uc81c\ub85c \uc774\ub904\uc84c\ub2e4\uace0 \uac00\uc815\ud558\uba74, \ud5c8\uc820\ucfe0\uc774 \ubc15\uc0ac\ub294 ‘\ud06c\ub9ac\uc2a4\ud37c \uce74\uc2a49’\uc774\ub77c \ubd88\ub9ac\ub294 \ud658\uc0c1\uc801\uc778 \uc720\uc804\uc790 \uad50\uc815 \ub3c4\uad6c\ub97c \uc778\uac04 \ub09c\uc790\uac00 \uc218\uc815\ub41c \uc9c1\ud6c4, \ubc30\uc544\uc5d0 \uc0ac\uc6a9\ud588\ub2e4. \uadf8\uc758 \ubaa9\ud45c\ub294 CCR5\ub77c\uace0 \ubd88\ub9ac\ub294 \uc720\uc804\uc790\ub97c \ubc14\uafb8\ub294 \uac83\uc774\ub2e4. \uc774 \uc720\uc804\uc790\ub294 \ubc31\ud608\uad6c \ubc14\uae65\ucabd\uc5d0 \uc788\ub294 \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4e0\ub2e4. \uc774 \ub2e8\ubc31\uc9c8\uc740 \uba74\uc5ed\uc2dc\uc2a4\ud15c\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ucc28\uc9c0\ud558\ub294\ub370 \uc774\ub97c T\uc138\ud3ec\ub77c\uace0 \ubd80\ub978\ub2e4. CCR5\uac00 \uacb0\ud54d\ub41c T\uc138\ud3ec\ub294 HIV\uc5d0 \uac10\uc5fc\ub418\uc9c0 \uc54a\ub294\ub2e4\ub294(\ud639\uc740 \uac70\uc758 \uac10\uc5fc\ub418\uc9c0 \uc54a\ub294\ub2e4\ub294) \uc5ec\ub7ec \uc99d\uac70\uac00 \uc788\ub2e4. \ubd81\uc720\ub7fd \uc0ac\ub78c\ub4e4\uc758 \uc57d 1%\ub294(\uadf8\ubc16\uc5d0 \uc18c\uc218\uc758 \uc0ac\ub78c\ub4e4\uc774) CCR5\uc5d0 \uc791\uc740 \ubcc0\ud654\uac00 \uc788\uc5b4 HIV\uc5d0 \uac10\uc5fc\ub418\uc9c0 \uc54a\ub294 \uac83\uc73c\ub85c \uc54c\ub824\uc838 \uc788\ub2e4. \ub530\ub77c\uc11c \uadf8\uc758 \ubaa9\ud45c\ub294 HIV\uc5d0 \uac10\uc5fc\uc5d0 \uba74\uc5ed\ub825\uc774 \uc788\ub294 \ubc30\uc544\ub97c(\uadf8\ub9ac\uace0 \uc544\uae30\ub4e4, 10\ub300\ub4e4, \uc131\uc778\ub4e4) \uc81c\uacf5\ud558\ub294 \uac83\uc774\uc5c8\ub2e4. \ud558\uc9c0\ub9cc \uadf8\uac00 \ubc1c\ud45c\ud55c \uc790\ub8cc\ub294 \uc30d\ub465\uc774 \uc911 \ud55c \uba85\uc740 \uc138\ud3ec\uc758 \uc808\ubc18\ub9cc \uc218\uc815\ub410\ub2e4. \ub9cc\uc57d \uadf8\ub140\uc758 \uc138\ud3ec \uc911 \uc808\ubc18\uc774 CCR5\ub97c \uac00\uc9c0\uace0 \uc788\ub2e4\uba74 \uadf8\ub140\ub294 \uc5ec\uc804\ud788 HIV \uac10\uc5fc\uc5d0 \ucde8\uc57d\ud558\ub2e4. \uc30d\ub465\uc774 \uc911 \ub2e4\ub978 \ud55c\uba85\uc740 \ubaa8\ub4e0 \uc138\ud3ec\uc758 DNA\uac00 \ubcc0\ud55c \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc9c0\ub9cc \ud5c8\uc820\ucfe0\uc774 \ubc15\uc0ac\uac00 \uc758\ub3c4\ud55c \uac83\uc740 \uc544\ub2c8\uc5c8\ub2e4. \uc6b0\ub9ac\ub294 \uc5ec\uc804\ud788 \uadf8\ub140\uac00 HIV\uac10\uc5fc\uc73c\ub85c\ubd80\ud130 \uc644\ubcbd\ud558\uac8c, \ub610\ub294 \uc77c\ubd80 \uc800\ud56d\ud560 \uc218 \uc788\ub294 \uba74\uc5ed\uc2dc\uc2a4\ud15c\uc744 \uac16\ucdc4\ub294\uc9c0 \uc54c \uc218 \uc5c6\ub2e4.<\/p>\n![\"\"](\"https:\/\/post-phinf.pstatic.net\/MjAxODEyMDhfMjU3\/MDAxNTQ0MjQ4OTgzMzA4.9xvPSzMi7SQZY9nuY5hoFhvncPf-IbO5Ns8nfEoX4P8g.flQRdUEXXbWFiRIBuDZ1ERB1q9crTN2L9k61Ifii5kwg.JPEG\/%EC%9C%A0%EC%A0%84%EC%9E%90%EA%B0%80%EC%9C%84.jpg?type=w1200\")
<\/a><\/p>\n
\n\ub450\ubc88\uc9f8 \uc704\ud5d8\uc740 CCR5\uac00 \uc5c6\ub294 \uc720\uc804\uc790\ub294 \uc790\uc2e0\ub9cc\uc758 \ubb38\uc81c\ub97c \uac16\uace0 \uc788\uc744 \uc218 \uc788\ub2e4\ub294 \uc810\uc774\ub2e4. CCR5\uac00 \uc5c6\ub294 \ubd81\uc720\ub7fd \uc131\uc778\ub4e4\uc740 \uac89\uc73c\ub85c \ubcf4\uae30\uc5d0\ub294 \uac74\uac15\ud574 \ubcf4\uc774\uc9c0\ub9cc \ub2e4\ub978 \ubb38\uc81c\uac00 \uc788\ub294\uc9c0 \uba74\ubc00\ud788 \uad00\ucc30\ub41c \uc801\uc774 \uc5c6\ub2e4. \uc608\ub97c \ub4e4\uc5b4 CCR5\uac00 \uc5c6\uc744 \uacbd\uc6b0 \uc6e8\uc2a4\ud2b8\ub098\uc77c \ubc14\uc774\ub7ec\uc2a4\ub098 \uc778\ud50c\ub8e8\uc5d4\uc790\uc5d0 \ucde8\uc57d\ud560 \uc218 \uc788\ub2e4\ub294 \uc99d\uac70\ub3c4 \ub098\uc624\uace0 \uc788\ub2e4.
\n\uc544\uae30\uc5d0\uac8c \uc788\uc5b4\uc11c \uc7a0\uc7ac\uc801\uc778 \uc774\uc775\uc740 HIV\uc5d0 \ub300\ud55c \uba74\uc5ed\uc774\uc9c0\ub9cc \uc774\uac83\uc774 \ucc28\uc9c0\ud558\uace0 \uc788\ub294 \ube44\uc911\uc740 \uc0c1\ub2f9\ud788 \uc801\ub2e4. \uc30d\ub465\uc774 \uc911 \ud55c\uba85\uc740 CCR5\uac00 \uc644\uc804\ud788 \uc81c\uac70\ub418\uc9c0 \uc54a\uc544 HIV\uc5d0 \ub300\ud55c \uba74\uc5ed\ub2a5\ub825\uc774 \uc5c6\uc744 \uac83\uc774\ub2e4. \ub610\ud55c \ub450 \uc544\uc774\ub294 \ubaa8\ub450 HIV\uc5d0 \ub178\ucd9c\ub410\uc744 \ub54c \uac10\uc5fc\ub420 \uac00\ub2a5\uc131\uc744 \uc870\uae08\uc774\ub77c\ub3c4 \uac16\uace0 \uc788\ub2e4. HIV\ub294 \uc774\ubbf8 \uad00\ub9ac \uac00\ub2a5\ud55c \uc9c8\ubcd1\uc774\ub2e4. 20\ub144 \ub0b4\uc5d0 \uadf8 \uc9c8\ubcd1\uc744 \uc5bc\ub9c8\ub098 \uc27d\uac8c \uc608\ubc29\ud560 \uc218 \uc788\uac8c \ub420\uc9c0 \uc54c \uc218 \uc5c6\ub2e4.
\n\uacfc\ud559\u00b7\uc758\ud559\uc5d0\uc11c \uc5bb\uc744 \uc218 \uc788\ub294 \uc7a0\uc7ac\uc801\uc778 \uc774\ub4dd\uc740 \ud06c\ub9ac\uc2a4\ud37c \uc720\uc804\uc790 \uac00\uc704\ub85c \uc720\uc804\uc790\uac00 \uad50\uc815\ub41c \uc544\uae30\uac00 \ud0dc\uc5b4\ub0a0 \uc218 \uc788\ub2e4\ub294 \uc810\uc774\ub2e4. \ud558\uc9c0\ub9cc \uc774 \uae30\uc220\uc774 \uc131\uacf5\ud560 \uac00\uce58\uac00 \uc788\ub2e4\uba74, \uc774\uac83\uc740 \ub2e4\ub978 \ub300\uc548\uc774 \uc5c6\ub294 \uc2ec\uac01\ud55c \uc9c8\ubcd1\uc744 \ub300\uc0c1\uc73c\ub85c \uc9c4\ud589\ub418\uc5b4\uc57c \ud558\uba70 \uc774\ubc88 \uc77c\uacfc\ub294 \uc804\ud600 \ub2e4\ub978 \ubc29\ud5a5\uc73c\ub85c \uc9c4\ud589\ub410\uc5b4\uc57c \ud588\ub2e4.<\/p>\nGeneticists retract study suggesting first CRISPR babies might die early<\/h4>\n
Researchers rapidly corrected finding through discussions on social media and preprints.<\/h5>\n
![\"A](\"\/\/media.nature.com\/w800\/magazine-assets\/d41586-019-03032-2\/d41586-019-03032-2_17257846.jpg\")
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