{"id":2016,"date":"2018-10-05T12:07:31","date_gmt":"2018-10-05T03:07:31","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=2016"},"modified":"2018-10-05T12:07:31","modified_gmt":"2018-10-05T03:07:31","slug":"how-to-lose-your-inheritance","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2016","title":{"rendered":"How to lose your inheritance"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\ubc30\uc544\uc904\uae30\uc138\ud3ec\uc758 \ubd84\ud654 \uacfc\uc815\uc5d0\uc11c\uc758 \uc804\uc0ac\uc778\uc790\uc758 \uc911\uc694\uc131\uc5d0 \uad00\ud55c \ub0b4\uc6a9\uc785\ub2c8\ub2e4.<\/p>\n<p>(\uc6d0\ubb38: <a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29\"><u>\uc5ec\uae30<\/u><\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n<p>&nbsp;<\/p>\n<h5>In developing embryos, molecular and physical differences divide the cells that will form eggs or sperm and those that will form the body. The mouse protein OTX2 directs this decision by blocking reproductive-cell fate.<\/h5>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div class=\"article__body serif cleared\">\n<p>In an ultimate act of family planning, the cells destined to contribute to the next generation of an organism are set aside early in embryonic development. It is unclear why primordial germ cells (PGCs), the precursors of eggs and sperm, are established so early in the development of many multicellular organisms. This process of establishing the germ line involves both preventing a non-reproductive-cell (somatic-cell) fate and activating a cellular state known as pluripotency \u2014 the ability to give rise to the many different cell types in the body. Understanding how the germ line forms is a key requirement for the goal of generating healthy eggs and sperm\u00a0<i>in vitro<\/i>\u00a0for fertility treatment in the clinic. Work in this area has focused mainly on identifying proteins that specify germline fate, but comparatively little is known about why somatic cells do not acquire such a fate.\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41586-018-0581-5\" data-track=\"click\" data-label=\"https:\/\/www.nature.com\/articles\/s41586-018-0581-5\" data-track-category=\"body text link\">Writing in\u00a0<i>Nature<\/i><\/a>, Zhang\u00a0<i>et al<\/i>.<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR1\">1<\/a><\/sup>\u00a0reveal that the formation of PGCs in mice can be blocked by a protein called OTX2.<\/p>\n<p>&nbsp;<\/p>\n<aside class=\"recommended pull pull--left sans-serif\" data-label=\"Related\"><a href=\"https:\/\/www.nature.com\/articles\/s41586-018-0581-5\" data-track=\"click\" data-track-label=\"recommended article\"><img decoding=\"async\" class=\"recommended__image\" src=\"https:\/\/media.nature.com\/w400\/magazine-assets\/d41586-018-06849-5\/d41586-018-06849-5_16156098.jpg\" \/><\/a><\/p>\n<p class=\"recommended__title serif\">Read the paper: OTX2 restricts entry to the mouse germline<\/p>\n<\/aside>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>In many animals, specification of the germ line operates like a hereditary monarchy in which, like the direct transmission of the crown jewels from one generation to the next, the passage of molecular components in the cytoplasm down the generations determines the cells that will form PGCs. However, some animals, including salamanders, crickets, mice and possibly humans, take a different approach. In the early mouse embryo, designation of the germ line occurs as a result of cells being in the right place at the right time, rather than inheriting the species\u2019 crown jewels. In this inductive fate-determination scenario, cells of a cylindrically shaped region of pluripotent cells known as the epiblast are coaxed into adopting a PGC fate by signals from supporting extraembryonic tissues adjacent to the embryo.<\/p>\n<p>In this mode of germline formation, the instructive cues that travel between cells include proteins of the Wnt and BMP families<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR2\">2<\/a><\/sup>. PGCs normally form at a predictable location in the epiblast (Fig. 1). However,\u00a0<i>in vivo<\/i>\u00a0grafting experiments in mouse embryos revealed that cells from elsewhere in the epiblast have the capacity to become PGCs if they are transplanted to that location<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR3\">3<\/a><\/sup>. The search for the components that drive germline fate in epiblast cells in response to the \u2018kingmaker\u2019 BMP proteins identified the transcription-factor proteins BLIMP1, PRDM14 and AP2\u03b3<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR4\">4<\/a><\/sup><sup>,<\/sup><sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR5\">5<\/a><\/sup>. This trio of proteins not only drives the expression of genes required to make the germ line, but also blocks the expression of genes associated with a somatic-cell fate<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR4\">4<\/a><\/sup><sup>,<\/sup><sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR5\">5<\/a><\/sup>.<\/p>\n<p>&nbsp;<\/p>\n<figure class=\"figure\">\n<div class=\"embed intensity--high\">\n<div class=\"embed intensity--high\"><img decoding=\"async\" class=\"figure__image\" src=\"https:\/\/media.nature.com\/w800\/magazine-assets\/d41586-018-06849-5\/d41586-018-06849-5_16164004.jpg\" alt=\"\" data-src=\"\/\/media.nature.com\/w800\/magazine-assets\/d41586-018-06849-5\/d41586-018-06849-5_16164004.jpg\" \/><\/div>\n<\/div><figcaption>\n<p class=\"figure__caption sans-serif\"><span class=\"mr10\"><b>Figure 1 | Expression of the transcription factor OTX2 declines in cells that will form primordial germ cells.<\/b>\u00a0Zhang\u00a0<i>et al<\/i>.<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR1\">1<\/a><\/sup>\u00a0report how primordial germ cells (PGCs), the precursors of egg and sperm cells, form\u00a0<i>in vivo<\/i>\u00a0in mice from cells in an embryonic region called the epiblast. The formation of PGCs requires a signal from BMP proteins in the adjacent extraembryonic region<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR2\">2<\/a><\/sup>. The authors report that there is a fall in OTX2 expression in the epiblast region where PGCs will subsequently arise. The drop in OTX2 expression in these cells is followed by a rise in the expression of other transcription factors \u2014 BLIMP1, PRDM14 and AP2\u03b3 \u2014 that are involved the formation of PGCs<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR4\">4<\/a><\/sup><sup>,<\/sup><sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR5\">5<\/a><\/sup>, which form in an area adjacent to a layer of embryonic cells called the mesoderm. The authors\u2019 results indicate that OTX2 blocks the establishment of PGCs.<\/span><\/p>\n<\/figcaption><\/figure>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>The process of PGC development can be recapitulated\u00a0<i>in vitro,<\/i>\u00a0starting from mouse embryonic stem (ES) cells that can be induced to form epiblast-like cells. If these epiblast-like cells are exposed to BMPs and certain other factors, then as many as 13.5% of the cells form PGCs<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR6\">6<\/a><\/sup>. However, if such epiblast-like cells are engineered to express BLIMP1, PRDM14 and AP2\u03b3, more than 30% form PGCs without the requirement<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR4\">4<\/a><\/sup>for BMPs. Yet knowing that a particular pathway can drive the formation of PGCs doesn\u2019t answer the questions of whether the default pathway of cellular differentiation in embryonic development is to form germline or somatic cells, or whether all of the cells in the epiblast are equally capable of becoming germline cells. Both matters have implications for our understanding of the evolution of multicellularity, as well as for our ability to generate healthy eggs or sperm from stem cells for clinical applications.<\/p>\n<p>Zhang and colleagues studied OTX2, a transcription factor known to be involved in the development of the nervous system.\u00a0<i>In vitro<\/i>\u00a0studies had revealed<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR7\">7<\/a><\/sup>\u00a0that OTX2 promotes the transition of mouse ES cells into epiblast-like cells. Zhang\u00a0<i>et al<\/i>. scrutinized the expression of OTX2 in mouse stem cells that were differentiating into germline cells\u00a0<i>in vitro<\/i>. They found that, in epiblast-like cells progressing towards PGC formation, OTX2 levels decline 12\u201324 hours before BLIMP1, PRDM14 and AP2\u03b3 are upregulated. The authors\u2019\u00a0<i>in vivo<\/i>\u00a0analysis in mice produced similar results (Fig. 1). Considered together, these patterns of expression make sense: the level of OTX2 is low in PGCs and ES cells, both of which exist in a state of pluripotency termed naive pluripotency, which is defined as the ability to give rise to all types of cell in the body. By contrast, the level of OTX2 is high in the epiblast and in ES-cell-derived epiblast-like cells, which are considered to be more restricted in the number of cell lineages they can form.<\/p>\n<p>The timing of the OTX2 decline before the transition from epiblast-cell to PGC fate raises the question of whether OTX2 might prevent cells from transitioning into PGCs. To investigate this, Zhang\u00a0<i>et al.<\/i>\u00a0studied the formation of PGCs in the absence of OTX2. Compared with the situation for wild-type cells, elevated numbers of PGCs were found if embryos lacked the\u00a0<i>Otx2<\/i>\u00a0gene, or if epiblast-like cells grown\u00a0<i>in vitro<\/i>\u00a0were\u00a0<i>Otx2<\/i>-deficient. Conversely, if epiblast-like cells were engineered to express higher than usual levels of OTX2, the formation of PGCs was prevented.<\/p>\n<p>Moreover, the authors found that the acquisition of PGC fate in the absence of\u00a0<i>Otx2<\/i>\u00a0could be accomplished\u00a0<i>in vitro\u00a0<\/i>without the usual requirements of BLIMP1 and signalling molecules called cytokines. This was unexpected because\u00a0<i>in vivo<\/i>\u00a0and\u00a0<i>in vitro<\/i>\u00a0experiments<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR8\">8<\/a><\/sup><sup>,<\/sup><sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR9\">9<\/a><\/sup>\u00a0have indicated that PGC production requires BLIMP1. How is the requirement for BLIMP1 in germline-cell formation bypassed? Given that OTX2 promotes a form of pluripotency in the epiblast that is more restricted than that of naive pluripotency<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR7\">7<\/a><\/sup>, perhaps the primary function of BLIMP1 is to create a naive state of pluripotency for newly forming PGCs.<\/p>\n<p>The authors\u2019 results are consistent with a model in which BMPs, possibly acting through Wnts, cause the level of OTX2 to decline. This reduction in OTX2 is one of the earliest known steps that determine whether an epiblast cell will acquire a germ-cell or somatic-cell fate. In an intriguing parallel to the system in fruit flies and worms, in which transcription is repressed altogether and cytoplasmic \u2018crown jewels\u2019 are inherited<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR10\">10<\/a><\/sup>, the first commitment to a PGC fate in mice is now revealed to be a process in which cells are defined by what they are not. Extinguishing the transcription factor OTX2 prevents it from driving gene expression associated with the more-restricted state of pluripotency of the epiblast<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR7\">7<\/a><\/sup>, instead making way for the naive pluripotency needed for PGCs.<\/p>\n<p>The authors show that the absence of OTX2 drives PGC formation, but it remains to be determined whether these PGCs differentiate normally and form fully functional eggs and sperm. Might the levels of OTX2 affect the fitness of germline cells? For example, would germline cells that have low levels of OTX2 be less likely to successfully contribute to reproduction than cells in which OTX2 has been completely extinguished? Conversely, does the level of OTX2 affect the fitness of somatic cells?<\/p>\n<p>Many other questions remain to be answered. How do BMPs and Wnts cause a decline in OTX2 levels? What is the regulatory relationship between OTX2 and other transcription factors that act in developing PGCs? In the development of the mouse eye<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR11\">11<\/a><\/sup>, OTX2 drives the expression of BLIMP1 in a process linked to a switch between two types of cell fate, yet in the PGCs, BLIMP1 seems to function after OTX2 levels have declined.<\/p>\n<p>In the developing ear of the fruit fly\u00a0<i>Drosophila melanogaster<\/i><sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR12\">12<\/a><\/sup>, the transcription of OTX2 is directly regulated by the transcription factor N-myc. The known roles of Myc-family genes in metabolism and in a process known as cell competition<sup><a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06849-5?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29#ref-CR13\">13<\/a><\/sup>\u00a0suggest that even minor variations in OTX2 levels in the epiblast might reflect a biologically meaningful variation in the fitness of cells that will go on to form the somatic-cell lineages or the germ line. In other words, if it turns out that the levels of Myc correlate with the health of an epiblast cell and its ability to outcompete its neighbouring cells, and if Myc controls the level of OTX2 in mice, then OTX2 might have a role in the fitness of epiblasts, and perhaps in that of PGCs.<\/p>\n<p>OTX2 could provide an avenue for investigating the cell-fate decision between forming germline and somatic cells, and might offer ways of improving PGC differentiation in\u00a0<i>in vitro<\/i>\u00a0approaches. If this mechanism of OTX2-mediated regulation of PGC fate in mice is evolutionarily conserved, then perhaps similar progress might be made in such studies of human cells.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div class=\"emphasis\">doi: 10.1038\/d41586-018-06849-5<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; \ubc30\uc544\uc904\uae30\uc138\ud3ec\uc758 \ubd84\ud654 \uacfc\uc815\uc5d0\uc11c\uc758 \uc804\uc0ac\uc778\uc790\uc758 \uc911\uc694\uc131\uc5d0 \uad00\ud55c \ub0b4\uc6a9\uc785\ub2c8\ub2e4. (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) &nbsp; In developing embryos, molecular and physical differences divide the cells that will<a href=\"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2016\" class=\"more-link\">(more&#8230;)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[33,29,30],"tags":[],"class_list":["post-2016","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","category-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":4849,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4849","url_meta":{"origin":2016,"position":0},"title":"Modeling the early development of a primate embryo","author":"biochemistry","date":"November 15, 2019","format":false,"excerpt":"\u00a0 \u00a0 Because mammalian embryos develop inside the uterus after implantation, they are practically inaccessible for direct observation and experimental analysis of the developmental process. To visualize and study the development of post-implantation embryos, it is necessary to develop a technology that maintains the viability and growth of embryos ex\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1313,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1313","url_meta":{"origin":2016,"position":1},"title":"Did CRISPR really fix a genetic mutation in these human embryos?","author":"biochemistry","date":"August 9, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 Researchers provide more evidence for their landmark claim that gene editing rid embryos of a disease mutation \u2014 but scientists are still arguing over the results. \u00a0 \u00a0 Eight-cell embryos injected with the gene editor CRISPR\u2013Cas9.Credit: H. Ma et al.\/Nature \u00a0 \u00a0 \u00a0 Biologists who\u2026","rel":"","context":"In &quot;Essays on Science&quot;","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1121,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1121","url_meta":{"origin":2016,"position":2},"title":"Double trouble at the beginning of life","author":"biochemistry","date":"July 17, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) \u00a0 Science\u00a0\u00a013 Jul 2018: Vol. 361, Issue 6398, pp. 128-129 DOI: 10.1126\/science.aau3216 \u00a0 \u00a0 Every human life begins with the fertilization of an egg (1). Once the egg and the sperm have fused, the parental chromosomes need to be united. To this end, the egg\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4088,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4088","url_meta":{"origin":2016,"position":3},"title":"Embryo-like structures created from human stem cells","author":"biochemistry","date":"September 17, 2019","format":false,"excerpt":"\u00a0 \u00a0 New method makes it easier to create structures to model early human development, but raises ethical issues. \u00a0 \u00a0 An early human embryo. Structures with similar features could be used to study human development.Credit: Dr Yorgos Nikas\/SPL \u00a0 \u00a0 Biologists have developed a way to use human stem\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4726,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4726","url_meta":{"origin":2016,"position":4},"title":"What does it mean to be alive?","author":"biochemistry","date":"November 2, 2019","format":false,"excerpt":"\u00a0 \u00a0 \u00a0 \u00a0 A small bundle of human nerve cells are being cultured in a petri dish. The cells divide. They differentiate into cell types found in the brain. The cell network grows dense and develops brain-like structures\u2014layers and folds. The cells begin to signal. The brain cell cluster\u2026","rel":"","context":"In &quot;'08. \uc0dd\uba85\uccb4\uc758 \uae30\uc6d0\uacfc \uc18d\uc131'\uacfc '09. \uc0dd\uba85\uccb4\uc758 \uc5f0\uc18d\uc131\uacfc \uc720\uc804' \uad00\ub828&quot;","block_context":{"text":"'08. \uc0dd\uba85\uccb4\uc758 \uae30\uc6d0\uacfc \uc18d\uc131'\uacfc '09. \uc0dd\uba85\uccb4\uc758 \uc5f0\uc18d\uc131\uacfc \uc720\uc804' \uad00\ub828","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=43"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4472,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4472","url_meta":{"origin":2016,"position":5},"title":"Cell identity reprogrammed","author":"biochemistry","date":"October 16, 2019","format":false,"excerpt":"\u00a0 \u00a0 The discovery that cell differentiation can be reversed challenged theories of how cell identity is determined, laying the foundations for modern methods of reprogramming cell identity and promising new regenerative therapies. \u00a0 \u00a0 All cells of an organism derive from a single cell. 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