{"id":1960,"date":"2018-10-02T08:21:22","date_gmt":"2018-10-01T23:21:22","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=1960"},"modified":"2019-10-16T11:33:44","modified_gmt":"2019-10-16T02:33:44","slug":"2018%eb%85%84-%eb%85%b8%eb%b2%a8%ec%83%9d%eb%a6%ac%ec%9d%98%ed%95%99%ec%83%81-%ec%a0%9c%ec%9e%84%ec%8a%a4-%ec%95%a8%eb%a6%ac%ec%8a%a8%c2%b7%ed%98%bc%ec%a1%b0-%eb%8b%a4%ec%8a%a4%ec%bf%a0-%ea%b3%b5","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1960","title":{"rendered":"2018\ub144 \ub178\ubca8\uc0dd\ub9ac\uc758\ud559\uc0c1, \uc81c\uc784\uc2a4 \uc568\ub9ac\uc2a8\u00b7\ud63c\uc870 \ub2e4\uc2a4\ucfe0 \uacf5\ub3d9\uc218\uc0c1 – \uba74\uc5ed\ud56d\uc554\uc81c \uc774\uc57c\uae30"},"content":{"rendered":"

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\uba74\uc5ed\ud56d\uc554\uc81c \uc5f0\uad6c\ubd84\uc57c \uc5f0\uad6c\uc790\uc778 \uc81c\uc784\uc2a4 \uc568\ub9ac\uc2a8\uacfc \ud63c\uc870 \ub2e4\uc2a4\ucfe0\uac00 2018\ub144 \ub178\ubca8\uc0dd\ub9ac\uc758\ud559\uc0c1\uc744 \uc218\uc0c1\ud588\uad70\uc694^^<\/p>\n

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James Allison and Tasuku Honjo pioneered treatments that unleash the body\u2019s own immune system to attack cancer cells.<\/h5>\n

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James Allison and Tasuku Honjo share the 2018 Nobel Prize in Physiology or Medicine.<\/span>Left: Richard Drew\/AP\/Shutterstock. Right: MEXT\/CC BY 4.0<\/a><\/p>\n<\/figcaption><\/figure>\n

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Two scientists who pioneered an entirely new way to treat cancer have won the 2018 Nobel Prize in Physiology or Medicine.<\/p>\n

James Allison at the University of Texas MD Anderson Cancer Center in Houston and Tasuku Honjo at Kyoto University in Japan will share the 9 million Swedish kronor (US$1 million) prize.<\/p>\n

The pair showed how proteins on immune cells can be used to manipulate the immune system so that it attacks cancer cells. The approach has since led to the development of therapies that have been hailed for extending survival in some people with cancer by years, and even wiped out all signs of disease in some people with advanced cancers. Researchers have flocked to the approach, and immunotherapy is\u00a0now one of the hottest areas in cancer research<\/a>.<\/p>\n

Early excitement<\/h6>\n

Allison is in New York for an immunology conference, and was awoken at 5.30 by a call from his son delivering the good news. By 6.30, colleagues were banging on the door of his hotel room bearing champagne for an impromptu party. The Nobel Committee only reached him some time after that.<\/p>\n

\u201cIt still hasn\u2019t completely dawned on me,\u201d said Allison, at a press conference. \u201cI was a basic scientist. To have my work really impact people is one of the best things I could think about. It\u2019s everybody\u2019s dream.\u201d<\/p>\n

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In the 1990s, Allison, then at the University of California, Berkeley, was one of several scientists who studied a \u2018checkpoint\u2019 protein, CTLA-4, that acts as a brake on immune cells called T cells. In 1997, Allison and his colleagues engineered an antibody that could bind to CTLA-4, removing the brakes on T-cell activity and unleashing them to attack cancer cells in mice. A clinical study in 2010 found that the antibody had a striking effect on people with advanced melanoma, a form of skin cancer1<\/a><\/sup>.<\/p>\n

Working independently of Allison, in 1992, Honjo discovered a different T-cell protein, PD-1, which also acts as a brake on the immune system but by a different mechanism. PD-1 went on to become a target in the treatment of cancer. In 2012, research in people revealed that the protein was\u00a0effective against several different cancers<\/a>, including lung cancer, a major killer2<\/a><\/sup>. The results were dramatic \u2014 some patients with metastatic cancer went into long-term remission, raising the possibility of a cure.<\/p>\n

Releasing the brakes<\/h6>\n

\u201cAllison\u2019s and Honjo\u2019s discoveries have added a new pillar in cancer therapy. It represents a completely new principle, because unlike previous strategies, it is not based on targeting the cancer cells, but rather the brakes \u2014 the checkpoints \u2014 of the host immune system\u201d, said Klas K\u00e4rre, a member of the Nobel Committee and an immunologist at the Karolinska Institute in Stockholm who described the work of the prizewinners during the Nobel announcement. \u201cThe seminal discoveries by the two laureates constitutes a paradigmatic shift and a landmark in the fight against cancer.\u201d<\/p>\n

In recent years, clinical work on drugs that inhibit the CTLA-4 and PD-1 mechanisms \u2014 known as \u2018immune checkpoint therapy\u2019 \u2014 has developed apace. Treatments that block PD-1 have been shown to be effective in lung and renal cancers, lymphomas and melanoma. Recent clinical work that\u00a0combined therapies targeting CTLA-4 and PD-1<\/a>\u00a0in patients with melanoma showed that this approach can be even more effective than CTLA-4 alone3<\/a><\/sup>. Trials are now underway to evaluate the efficacy of checkpoint therapy against most types of cancer, and scientists are testing numerous other checkpoint proteins to see if they could act as targets.<\/p>\n

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But Allison and Honjo were not alone: others also made important early discoveries about checkpoint inhibitors, notes Gordon Freeman, an immunologist at the Dana-Farber Cancer Institute in Boston, Massachusetts, who was disappointed not to be recognized for his contributions. Freeman, along with immunologists Arlene Sharpe at Harvard Medical School in Boston and Lieping Chen at Yale University in New Haven, Connecticut, studied PD-1 and a molecule that binds to it called PD-L1.<\/p>\n

The drug ipilimumab, an antibody that inhibits CTLA-4, won approval from the US Food and Drug Administration (FDA) in 2011 and was the\u00a0first checkpoint inhibitor to reach patients<\/a>. But Freeman points out that CTLA-4 inhibitors have so far been shown to work only in melanoma. And the FDA has approved drugs that target PD-1 and PD-L1 to treat 13 different cancers. \u201cPD-1 and PD-L1 are what works in a really wide variety of people,\u201d he says. \u201cAnd our discoveries were foundational there.\u201d<\/p>\n

However, Freeman says that CTLA-4 paved the way, and that Allison had a key role in pushing the field. \u201cJim Allison has been a real advocate and champion of the idea of immunotherapy,\u201d he says. \u201cAnd CTLA-4 was a first success.\u201d<\/p>\n

Obvious choices<\/h6>\n

Immunologist Jerome Galon of the French national biomedical research agency, INSERM, in Paris, was not surprised by the committee\u2019s decision to award the prize to Honjo and Allison. \u201cI think they really deserve it,\u201d he says. \u201cYou can always multiply and have many other people, but these are the obvious two first choices.\u201d<\/p>\n

He adds that the prize reflects how far the immune approach to fighting cancer has come. When PD-1 inhibitors were shown to work against lung cancer in 2012, the field ignited, with researchers in academia and industry racing to find ways to expand the number of patients who could benefit from the drugs. \u201cTen years back, nobody was interested \u2014 nobody except a few immunologists,\u201d Galon says. \u201cIt\u2019s such a big change.\u201d<\/p>\n

In a 2013 interview with\u00a0Nature<\/i>, Allison described the resistance he met when he first tried to get pharmaceutical companies interested. \u201cIt was very frustrating,\u201d he said. \u201cThey said, \u2018It may work in mice, but it\u2019ll never work in people\u2019. The concept was new and it was so unusual.\u201d<\/p>\n

Allison marched from company to company in search of one that would take on the project. Ultimately, Bristol-Myers Squibb of New York City was the one to push ipilimumab over the finishing line. Since then, other pharmaceutical companies have developed checkpoint inhibitors that have been approved for use in people.<\/p>\n

Combination therapy<\/h6>\n

A major draw, says Galon, is the potential of these drugs to lengthen patients\u2019 lives by years, rather than just weeks or months. But only a fraction of patients experiences such dramatic responses, and researchers are racing to boost those numbers by combining checkpoint inhibitors with each other and with other treatments. \u201cThe huge benefit in comparison to other treatments is that patients are experiencing long-term survival,\u201d he says. \u201cUnfortunately, only a subgroup of patients is responding.\u201d<\/p>\n

Through it all, it\u2019s been thrilling to watch the field develop, says Freeman. \u201cIt\u2019s really been just an incredible amount of human creativity and energy,\u201d he says. \u201cIt\u2019s wonderful because so many cancer patients are doing better.\u201d<\/p>\n

In 2015, Allison\u00a0won a prestigious Lasker prize<\/a>\u00a0for his work on cancer immunotherapy. In 2016, Honjo won the Kyoto Prize in basic sciences, a global prize awarded by the Inamori Foundation.<\/p>\n

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doi: 10.1038\/d41586-018-06751-0<\/div>\n

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http:\/\/biz.chosun.com\/site\/data\/html_dir\/2018\/10\/01\/2018100103159.html<\/p>\n

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3\uc138\ub300 \uc554(\u764c)\uce58\ub8cc \ubb38 \uc5f0 \u7f8e\u00b7\u65e5 \uacfc\ud559\uc790\ub4e4 \ub178\ubca8\uc758\ud559\uc0c1 \uc218\uc0c1\u2026’\uba74\uc5ed \uad00\ubb38 \uc218\uc6a9\uccb4’ \uae30\ub2a5 \uaddc\uba85<\/h5>\n

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\ub178\ubca8\uc704\uc6d0\ud68c\ub294 “\ub9e4\ub144 \uc218\ubc31\ub9cc\uba85\uc758 \uc0ac\ub78c\ub4e4\uc744 \uc8fd\uc774\ub294 \uc554\uc740 \uc778\ub958\uc758 \uac00\uc7a5 \ud070 \uac74\uac15 \ubb38\uc81c \uc911 \ud558\ub098”\ub77c\uba70 “(\ub450 \uc5f0\uad6c\uc790\ub294) \uc554 \uc138\ud3ec\ub97c \uacf5\uaca9\ud558\ub294 \uc6b0\ub9ac\uc758 \uba74\uc5ed\uccb4\uacc4\uc640 \uae30\ub2a5\uc744 \uaddc\uba85\ud574, \uc554\uce58\ub8cc\uc758 \uc0c8\ub85c\uc6b4 \ud328\ub7ec\ub2e4\uc784\uc744 \uc138\uc6e0\ub2e4”\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

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2018\ub144 \ub178\ubca8 \uc0dd\ub9ac\uc758\ud559\uc0c1 \uc218\uc0c1\uc790\ub85c \uc81c\uc784\uc2a4 \uc568\ub9ac\uc2a8(James<\/span>\u00a0P\u00a0Allison<\/span>) \ubbf8\uad6d \ud14d\uc0ac\uc2a4\u00a0MD<\/span>\u00a0\uc564\ub354\uc2a8 \uc554\uc13c\ud130 \uad50\uc218\uc640 \ud63c\uc870 \ub2e4\uc2a4\ucfe0(\u672c\u5eb6\u4f51\u00b776) \uc77c\ubcf8 \uad50\ud1a0\ub300 \uc758\uacfc\ub300\ud559 \uad50\uc218\uac00 \uc120\uc815\ub410\ub2e4.(\uc67c\ucabd\ubd80\ud130) \/ \ub178\ubca8\uc704\uc6d0\ud68c \uc81c\uacf5<\/em><\/span><\/p>\n

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\uc554(\u764c) \uce58\ub8cc \ud328\ub7ec\ub2e4\uc784\uc740 1\uc138\ub300 \ud654\ud559\ud56d\uc554\uc81c, 2\uc138\ub300 \ud45c\uc801\ud56d\uc554\uc81c\ub97c \uac70\uccd0 3\uc138\ub300 \uba74\uc5ed\ud56d\uc554\uc81c \uce58\ub8cc\uae4c\uc9c0 \ubc1c\uc804\ud588\ub2e4. \uae30\uc874\uc758 \ud56d\uc554\uc81c\uac00 \uc554\uc138\ud3ec\ub97c \uc9c1\uc811 \uaca8\ub0e5\ud588\ub2e4\uba74, \uc0c8\ub86d\uac8c \ub4f1\uc7a5\ud55c \uba74\uc5ed\ud56d\uc554\uc81c\ub294 \uba74\uc5ed\uc138\ud3ec\ub97c \ud65c\uc131\ud654\uc2dc\ucf1c \uc554\uc138\ud3ec\ub97c \uc0ac\uba78\uc2dc\ud0a8\ub2e4. \uc778\uccb4\uc758 \uba74\uc5ed\uccb4\uacc4 \uae30\uc804\uc744 \ubc14\ud0d5\uc73c\ub85c \uac1c\ubc1c\ub41c \uba74\uc5ed\ud56d\uc554\uc81c\ub294 \ubfb0\uc871\ud55c \ud574\ubc95\uc774 \uc5c6\uc5c8\ub358 \uc554 \ud658\uc790\ub4e4\uc5d0\uac8c \uce58\ub8cc \ud6a8\uacfc\ub97c \ubcf4\uc774\uba74\uc11c \uc554 \uc815\ubcf5\uc758 \uc5f4\uc1e0\ub85c \ucd5c\uadfc \uae09\ubd80\uc0c1\ud588\ub2e4.<\/p>\n

\ubc14\ub85c \uc62c\ud574 \ub178\ubca8\uc0dd\ub9ac\uc758\ud559\uc0c1\uc744 \uc218\uc0c1\ud55c \ub450\uba85\uc758 \uacfc\ud559\uc790\uac00 3\uc138\ub300 \uc554 \uce58\ub8cc\uc758 \ubb38\uc744 \uc5f0 \uac83\uc774\ub2e4. \ub450 \uacfc\ud559\uc790\ub294\uc778\uccb4 \uba74\uc5ed\uae30\uc804\uc5d0 \uc788\uc5b4\uc11c \u2018\uba74\uc5ed\uad00\ubb38\uc218\uc6a9\uccb4(immune<\/span>\u00a0checkpoint<\/span>receptor<\/span>)\u2019\ub97c \ubc1c\uacac\ud558\uace0 \uadf8 \uae30\ub2a5\uc744 \ubc1d\ud614\ub2e4.<\/p>\n

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\uc774\ub7ec\ud55c \ubc1c\uacac\uc740 \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c \ub4f1 \uba74\uc5ed\ud56d\uc554\uc81c \uac1c\ubc1c\ub85c \uc774\uc5b4\uc84c\ub2e4. \uc0c8\ub86d\uac8c \uac1c\ubc1c\ub41c \uba74\uc5ed\uce58\ub8cc\uc81c\ub294 \ub2e4\uc591\ud55c \uc885\uc591\uc5d0\uc11c \uce58\ub8cc \ud6a8\uacfc\ub97c \ubcf4\uc5ec \uc554 \uce58\ub8cc\uc758 \uc0c8\ub85c\uc6b4 \ud76c\ub9dd\uc744 \uc81c\uc2dc\ud558\uace0 \uc788\ub2e4. \uae30\uc874 \uce58\ub8cc\uc81c \ub300\ube44 \uc804\uccb4 \uc0dd\uc874\uae30\uac04\uc744 \ub450 \ubc30 \uac00\uae4c\uc774 \ub298\ub9ac\ub294 \ub4f1 2011\ub144 \ucd9c\uc2dc \uc774\ud6c4 \uc554 \uce58\ub8cc\uc758 \ud328\ub7ec\ub2e4\uc784\uc744 \ubc14\uafe8\ub2e4\ub294 \ud3c9\uac00\ub97c \ubc1b\uace0 \uc788\ub2e4.<\/p>\n

2010\ub144 \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c \u2018\uc774\ud544\ub9ac\ubb34\ubc25\u2019\uc758 \uc545\uc131\ud751\uc0c9\uc885 \ud658\uc790\uc5d0 \ub300\ud55c \uce58\ub8cc \ud6a8\uacfc\uac00 \ucc98\uc74c \uc785\uc99d\ub410\uace0 2012\ub144\ubd80\ud130 \uc545\uc131\ud751\uc0c9\uc885 \ubfd0\ub9cc \uc544\ub2c8\ub77c \ud3d0\uc554\uc5d0 \ub300\ud55c \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c \ub2c8\ubcfc\ub8e8\ub9d9\uacfc \ud3a8\ube0c\ub864\ub9ac\uc8fc\ub9d9 \ub4f1\uc774 \uac1c\ubc1c\uc5d0 \uc131\uacf5\ud588\ub2e4. \uc774 \ud56d\uc554\uc81c\ub294 \uc774\ubbf8 \uad6d\ub0b4\uc5d0\uc11c\ub3c4 \ud5c8\uac00\ub410\uace0, \uc77c\ubd80 \uc885\uc591\uc5d0 \ub300\ud574\uc11c\ub294 \uac74\uac15\ubcf4\ud5d8 \uae09\uc5ec \uc801\uc6a9\ub3c4 \uc774\ub904\uc84c\ub2e4.<\/p>\n

\uc774\ub300\ud638 \uad50\uc218\ub294 “\uc774\ub7ec\ud55c \uba74\uc5ed\uad00\ubb38 \uce58\ub8cc\uc81c\uc758 \uc7a5\uc810\uc740 \uc0c1\ub300\uc801\uc73c\ub85c \ub0ae\uc740 \ubd80\uc791\uc6a9\uacfc \uc7a5\uae30\uac04\uc758 \ud6a8\uacfc\uac00 \uc9c0\uc18d\ub3fc \uc644\uce58\uae4c\uc9c0\ub3c4 \ubc14\ub77c\ubcfc \uc218 \uc788\ub2e4\ub294 \uc810”\uc774\ub77c\uba70 “\ubb3c\ub860 \ubaa8\ub4e0 \ud658\uc790\uac00 \ud574\ub2f9\uc57d\uc81c\ub85c\ubd80\ud130 \ud6a8\uacfc\ub97c \ubcf4\uc9c0\ub294 \ubabb\ud569\ub2c8\ub2e4\ub9cc, \uc774\ub7ec\ud55c \ub0b4\uc131\uae30\uc804\uc5d0 \ub300\ud55c \uc5f0\uad6c\ub3c4 \ube60\ub974\uac8c \uc9c4\ud589\ub418\uace0 \uc788\ub2e4”\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

\uc774 \uad50\uc218\ub294 “\uc5f0\uad6c\uc790\ub4e4\uc774 \ubc1c\uacac\ud55c \uba74\uc5ed\uad00\ubb38\uc218\uc6a9\uccb4\uc640 \uc774\uc5d0 \ub300\ud55c \uce58\ub8cc\uc81c \uac1c\ubc1c\uc774 \uc554\uc758 \uc644\uce58 \ub0b4\uc9c0\ub294 \uc7a5\uae30\uc0dd\uc874\uc744 \ubc14\ub77c\ubcfc \uc218 \uc788\uac8c \ud588\ub2e4\ub294 \uc810\uc5d0\uc11c \uc778\ub958\uc758 \uac74\uac15\uc5d0 \ud06c\uac8c \uae30\uc5ec\ud588\ub2e4”\uace0 \ub367\ubd99\uc600\ub2e4.<\/p>\n

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\ud63c\uc870 \ub2e4\uc2a4\ucfe0 \uad50\uc218\uc758 \ub178\ubca8\uc0c1 \uc218\uc0c1 \uc18c\uc2dd\uc744 \ub4e3\uace0 \uc77c\ubcf8 \uad50\ud1a0\ub300 \uc5f0\uad6c\ud300\uc774 \ud63c\uc870 \uad50\uc218\uc640 \ud568\uaed8 \uae30\ubed0\ud558\uace0 \uc788\ub2e4. \/\ud2b8\uc704\ud130 \uc81c\uacf5<\/em><\/span><\/p>\n

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 <\/p>\n

http:\/\/dongascience.donga.com\/news\/view\/24183<\/p>\n

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“\uc0c8\ub85c\uc6b4 \ud56d\uc554\uce58\ub8cc \uc2dc\ub300 \uc5f4\ub838\ub2e4” \ub178\ubca8\uc0c1 \ubc1c\ud45c\ud604\uc7a5 \uc774\ubaa8\uc800\ubaa8<\/h5>\n

 <\/p>\n

 <\/p>\n

2018\ub144 \ub178\ubca8 \uc0dd\ub9ac\uc758\ud559\uc0c1\uc740 \uba74\uc5ed\uce58\ub8cc\ub77c\ub294 \uac1c\ub150\uc744 \ub3c4\uc785\ud574 \uc554 \uce58\ub8cc\uc758 \uc0c8\ub85c\uc6b4 \uc7a5\uc744 \uc5f0 \uc81c\uc784\uc2a4 \uc568\ub9ac\uc2a8(70) \ubbf8\uad6d \uc564\ub354\uc2a8 \uc554\uc13c\ud130 \uad50\uc218\uc640 \ud63c\uc870 \ub2e4\uc2a4\ucfe0(76) \uc77c\ubcf8 \uad50\ud1a0\ub300 \uc758\ub300 \uba85\uc608\uad50\uc218\uc5d0\uac8c \ub3cc\uc544\uac14\ub2e4. \uc2a4\uc6e8\ub374 \uce74\ub864\ub9b0\uc2a4\uce74 \uc758\ub300 \ub178\ubca8\uc704\uc6d0\ud68c\ub294 1\uc77c \uc218\uc0c1\uc790 \ubc1c\ud45c \uc9c1\ud6c4 \uc774\ub4e4\uc758 \uc5c5\uc801\uacfc \uc120\uc815\uc0ac\uc720\ub97c \uc124\uba85\ud588\ub2e4. \uc774\uc5b4 \ud604\uc9c0 \uc5b8\ub860\uacfc\uc758 \uc9c8\uc758\uc751\ub2f5\uc774 \uc5f0\uc774\uc5b4 \uc9c4\ud589\ud588\ub2e4.<\/p>\n

 <\/p>\n

<\/span><\/p>\n

2018 \ub178\ubca8 \uc0dd\ub9ac\uc758\ud559\uc0c1 \uc218\uc0c1 \ubc1c\ud45c \ud6c4 \ub178\ubca8\uc704\uc6d0\ud68c\uc5d0\uc11c \uc120\uc815 \uc774\uc720\uc5d0 \ub300\ud574 \ubc1d\ud788\uace0 \uc788\ub2e4.<\/em><\/span><\/p>\n

 <\/p>\n

\ub2e4\uc74c\uc740 \ub178\ubca8\uc704\uc6d0\ud68c \uad00\uacc4\uc790\uc758 \uc124\uba85.<\/p>\n

-“\uba74\uc5ed\uc2dc\uc2a4\ud15c\uc740 \uc6b0\ub9ac\ub97c \ubcf4\ud638\ud55c\ub2e4. \uba74\uc5ed\uc2dc\uc2a4\ud15c \uc548\uc5d0\ub294 \ub2e4\uc591\ud55c \uc138\ud3ec\uc640 \ubd84\uc790\uac00 \uc788\uace0, \uc800\ub9c8\ub2e4 \uc11c\ub85c \ub2e4\ub978 \uae30\ub2a5\uc744 \ud558\uace0 \uc788\ub2e4. \ubc14\uc774\ub7ec\uc2a4\ub098 \ubc15\ud14c\ub9ac\uc544\uc758 \uacf5\uaca9\uc744 \ubc1b\uc558\uc744 \ub54c \uba74\uc5ed\uc2dc\uc2a4\ud15c\uc740 \uc2a4\uc2a4\ub85c \ub610\ub294 \ub2e4\ub978 \ubb3c\uc9c8\uc744 \ud1b5\ud574 \uc790\uc2e0\ub4e4\uc758 \uc5ed\ud560\uc744 \ud55c\ub2e4. \uc9c0\ub09c 50\ub144 \uac04 \ud601\uc2e0\uc801\uc778 \uc5f0\uad6c\ub4e4\uc744 \ud1b5\ud574\uc11c \uba74\uc5ed\uc2dc\uc2a4\ud15c\uc758 \uc5ed\ud560\uc774 \ub4dc\ub7ec\ub0ac\uace0, \uc554\uc138\ud3ec\uc5d0 \ub300\ud56d\ud558\ub294 \uba74\uc5ed\uc2dc\uc2a4\ud15c \uc5f0\uad6c\ub3c4 \uc774\uc5b4\uc84c\ub2e4. \ud558\uc9c0\ub9cc \ud6a8\uc728\uc801\uc778 \uce58\ub8cc\ubc95\uc740 \uc624\ub7ab\ub3d9\uc548 \ub098\ud0c0\ub098\uc9c0 \uc54a\uc558\ub2e4. \ubd84\uba85 \uc911\uc694\ud55c \ubd80\ubd84\uc774 \ube60\uc838\uc788\uc5c8\ub2e4. \uc624\ub298 \uc218\uc0c1\ud55c \ub450 \uc5f0\uad6c\uc790\uac00 \uadf8 \ud37c\uc990\uc744 \ub07c\uc6cc \ub9de\ucd94\ub294 \uc5ed\ud560\uc744 \ud588\ub2e4.”<\/p>\n

-“1980\ub144\ub300 \uc774\ud6c4 \u2018T\uc138\ud3ec\u2019\uc5d0 \ucd08\uc810\uc774 \ub9de\ucdb0\uc9c0\uae30 \uc2dc\uc791\ud588\ub2e4. \uacfc\ud559\uc790\ub4e4\uc740 \ub2f9\uc2dc \ud2b9\uc774\ud55c \uad6c\uc870\ub97c \uc778\uc2dd\ud558\ub294 T\uc138\ud3ec \uc218\uc6a9\uccb4\ub97c \ubc1c\uacac\ud588\ub2e4. \uc774 \ubb3c\uc9c8\uc740 \uc554\uc138\ud3ec\uac00 T\uc138\ud3ec\ub97c \uc5f0\uacb0\ud558\ub294 \uc5ed\ud560\uc744 \ud55c\ub2e4. T\uc138\ud3ec\ub294 \uc218\uc6a9\uae30\uc640 \ub0af\uc120 \ubb3c\uc9c8\uc744 \uc778\uc2dd\ud558\uba74 \ud65c\ub3d9\uc744 \ud558\uae30 \uc2dc\uc791\ud55c\ub2e4. T\uc138\ud3ec \ud45c\uba74\uc5d0 \uc788\ub294 \ub2e8\ubc31\uc9c8\ub4e4\uc740 \uc774 \ud65c\ub3d9\uc744 \uac00\uc18d\ud558\ub294 \uc5ed\ud560\uc744 \ud55c\ub2e4. \uc774 \ub2e8\ubc31\uc9c8\ub4e4\uc740 \u2018\ucf54\uc5b4 \uc218\uc6a9\uae30\u2019\ub77c\uace0 \ud55c\ub2e4. \uc774\uc5d0 \uc5f0\uad6c\uc790\ub4e4\uc740 \uc774\uac83\uc744 \uc790\uadf9\ud558\ub294 \uc5f0\uad6c\ub97c \ud558\uae30\uc5d0 \uc774\ub978\ub2e4. \ub9ce\uc740 \uc5f0\uad6c\uc790\ub4e4\uc774 \uc774\uc678\uc5d0 \uad00\ub828\ub41c \ubd84\uc790\ub4e4\uc774 \ub354 \uc788\uc744 \uac83\uc774\ub77c\uace0 \uc0dd\uac01\ud588\uace0, \uc77c\ubd80 \ub2e4\ub978 \ubd84\uc790\ub4e4\uc740 \uadf8 \ubc18\ub300 \uae30\ub2a5\uc744 \ud560 \uac83\uc774\ub77c\uace0 \uc0dd\uac01\ud588\ub2e4. \uadf8\ub9ac\uace0 \uadf8\uc911 \ud558\ub098\uac00\u00a0CTLA<\/span>-4\uc600\ub2e4. \uc774 \ubd84\uc790\ub97c \uae68\uc790 T\uc138\ud3ec\uac00 \uba48\ucd94\ub294 \uac83\uc774 \ubc1c\uacac\ub410\ub2e4. \uc568\ub9ac\uc2a8 \uad50\uc218\ub294 \uc774\ub97c \ubc1c\uacac\ud55c \uc5f0\uad6c\uc790 \uc911 \ud55c \uba85\uc774\ub2e4. \uc774\uac83\uc740 \uba74\uc5ed\uc138\ud3ec\uc778 \u2018T\uc138\ud3ec\u2019\uc758 \ud65c\ub3d9\uc744 \ubc29\ud574\ud558\ub294 \uac83\uc774\uc5c8\ub2e4.”<\/p>\n

-“\uc568\ub9ac\uc2a8 \uad50\uc218\ud300\uc740 \uc774\ub97c \ubc14\ud0d5\uc73c\ub85c \uc790\uac00\uba74\uc5ed \uc5f0\uad6c\ub97c \uc2dc\uc791\ud588\ub2e4. \uc5f0\uad6c\ud300\uc740\u00a0CTLA<\/span>-4\uc5d0 \ub300\ud55c \ud56d\uccb4\ub97c \ub9cc\ub4e4\uc5c8\ub2e4. \uc774 \ud56d\uccb4\ub294\u00a0CTLA<\/span>-4\ub97c \ud30c\uad34\ud588\uc73c\uba70, \uc774\ub294 T\uc138\ud3ec\uc758 \ud65c\ub3d9\uc744 \ucd09\uc9c4\ud588\ub2e4. \uadf8\ub807\uac8c \uac00\uc124\uc774 \uc138\uc6cc\uc9c0\uc790 1994\ub144 \ud06c\ub9ac\uc2a4\ub9c8\uc2a4\uc5d0 \ubbf8\uad6d\u00a0UC<\/span>\ubc84\ud074\ub9ac\uc5d0\uc11c \uc2e4\uc81c \uc2e4\ud5d8\uc774 \uc9c4\ud589\ub410\uace0, \uacb0\uad6d \uc774 \uc2e4\ud5d8\uc73c\ub85c \uc778\ud574 \uba74\uc5ed\uce58\ub8cc\ub77c\ub294 \uc0c8\ub85c\uc6b4 \uac1c\ub150\uc774 \ud0c4\uc0dd\ud588\ub2e4. \uc624\ub298\ub0a0 \uc4f0\uc774\ub294 \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c(\uba74\uc5ed\uce58\ub8cc\uc81c)\ub77c\ub294 \ub9d0\uc740 \uc774\ub54c \uc0dd\uacbc\ub2e4.”<\/p>\n

-“\uc774 \uc5f0\uad6c \uacb0\uacfc\ub294 \ucc98\uc74c\uc5d0 \uadf8\ub807\uac8c\uae4c\uc9c0 \ub9ce\uc740 \uad00\uc2ec\uc744 \ubc1b\uc740 \uac83\uc740 \uc544\ub2c8\uc5c8\ub2e4. \uadf8\ub7ec\ub2e4 \uc791\uc740 \uc0dd\uba85\uacfc\ud559\uae30\uc5c5\uc774 \uc784\uc0c1\uc2dc\ud5d8\uc6a9 \ud56d\uccb4\ub97c \uac1c\ubc1c\ud558\ub294\ub370 \ub3c4\uc804\ud588\ub2e4. \uba87 \ub144 \ud6c4, \ud53c\ubd80\uc554\uc758 \uc77c\uc885\uc778 \uc804\uc774\uc131\ud751\uc0c9\uc885 \ud658\uc79014\uba85\uc744 \ub300\uc0c1\uc73c\ub85c \uc2e4\uc81c \uc784\uc0c1\uc2dc\ud5d8\uc774 \uc9c4\ud589\ub410\ub2e4. (\ud604\uc7a5\uc5d0\uc11c \uc0ac\uc9c4\uc744 \ubcf4\uc5ec\uc8fc\uba70)\uc774 \uc0ac\uc9c4\uc774 \ud658\uc790\ub4e4\uc758 \uc0c1\ud0dc \ubcf4\uc5ec\uc900\ub2e4. \uc0c8\ub85c\uc6b4 \uce58\ub8cc\uc81c\ub294 \uc554\uc744 \uc0ac\ub77c\uc9c0\uac8c \ud588\ub2e4. \uba87\uba87 \ud658\uc790\uc5d0\uac8c\ub294 \ubd80\uc791\uc6a9\uc774 \ub098\ud0c0\ub098\uae30\ub3c4 \ud588\uc9c0\ub9cc \uae0d\uc815\uc801\uc778 \ubd80\ubd84\uc774 \ub354 \ub9ce\uc558\ub2e4.”<\/p>\n

-“2011\ub144 \ub9c8\uce68\ub0b4 \ub300\uaddc\ubaa8 \uc784\uc0c1\uc2dc\ud5d8\uc774 \uc2b9\uc778\ub410\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \ub9ce\uc740 \uc218\uc758 \ud658\uc790, \uadf8\ub9ac\uace0 \ub2e4\uc591\ud55c \uc554\uc885\ub958\ub97c \uce58\ub8cc\ud558\uae30 \uc704\ud574\uc11c\ub294 \ucd94\uac00\uc801\uc778 \uc5f0\uad6c\uac00 \ud544\uc694\ud588 \ud544\uc694\ud588\uae30 \ub54c\ubb38\uc774\ub2e4. \uadf8\ub9ac\uace0, \uadf8\uc640 \uad00\ub828\ub41c \uc5f0\uad6c\uac00 \uc77c\ubcf8\uc5d0\uc11c\ub3c4 \uc9c4\ud589\ub418\uace0 \uc788\uc5c8\ub2e4.”<\/p>\n

-“\uc568\ub9ac\uc2a8 \uad50\uc218\uac00 \uc5f0\uad6c\ub97c \ucc98\uc74c \uc2dc\uc791\ud558\ub358 \ub54c, \uc77c\ubcf8\uc5d0\uc120 \ubb34\uc2a8 \uc77c\uc774 \uc788\uc5c8\uc744\uae4c. 1992\ub144 \uc77c\ubcf8 \uad50\ud1a0\ub300 \ud63c\uc870 \ud0c0\uc2a4\ucfe0 \uad50\uc218\uac00 T\uc138\ud3ec\uc758 \ud45c\uba74\uc5d0\uc11c\u00a0PD<\/span>-1\uc774\ub780 \ub2e8\ubc31\uc9c8\uc744 \ubc1c\uacac\ud588\ub2e4. \uadf8\ub294 \ucc98\uc74c\uc5d0 \uc774\uac8c \ubb34\uc5c7\uc744 \ud558\ub294 \ub2e8\ubc31\uc9c8\uc778\uc9c0 \uc798 \ubab0\ub790\ub2e4. \ud63c\uc870 \uad50\uc218\ub294 \uadf8 \uae30\ub2a5\uc744 \uc774\ud574\ud558\uae30 \uc704\ud574 \ud601\uc2e0\uc801\uc778 \uc5f0\uad6c\ub97c \uc2dc\uc791\ud588\ub2e4. \uadf8\ub9ac\uace0 7\ub144 \uac04\uc758 \uc5f0\uad6c \ub05d\uc5d0 \uadf8\ub294\u00a0PD<\/span>-1\uc774 T\uc138\ud3ec\uc758 \uae30\ub2a5\uc744 \uc5b5\uc81c\ud558\ub294 \uc5ed\ud560\uc744 \ud55c\ub2e4\ub294 \uac83\uc744 \uc54c\uac8c \ub410\ub2e4. \ub610\ud55c \ud63c\uc870 \uad50\uc218\ub294\u00a0PD<\/span>-1\uc758 \ud55c \ubd80\ubd84(\ub9ac\uac04\ub4dc)\uc774 \uc554\uc138\ud3ec\uc5d0 \uc758\ud574\uc11c \ubc1c\ud604\ub41c\ub2e4\ub294 \uc810\uc744 \ubc1c\uacac\ud558\uae30\ub3c4 \ud588\ub2e4. \uc774\uc5d0 \ub530\ub77c\u00a0PD<\/span>-1\uc774 \uc554\uc5d0 \ub300\uc751\ud558\ub294 \ubc18\uc751\uc744 \ucd09\uc9c4\ud558\ub294 \uac83\uc744 \uc54c \uc218 \uc788\uc5c8\ub2e4.”<\/p>\n

-“\ud63c\uc870 \uad50\uc218\ub294 \uc950\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc2e4\ud5d8\uc744 \uac70\uccd0 \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(FDA<\/span>)\uc5d0\uc11c \uc2b9\uc778\uc744 \ubc1b\uace0 2014\ub144\uc5d4 \ud751\uc0c9\uc885, 2015\ub144\uc5d4 \ud3d0\uc554\uacfc \uc2e0\uc7a5\uc554\uc744 \ub300\uc0c1\uc73c\ub85c \uc784\uc0c1\uc2dc\ud5d8\uc5d0 \ub3cc\uc785\ud55c\ub2e4. \ud3d0\uc554 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc2e4\ud5d8\uc5d0\uc11c \ud56d\uccb4 \uc801\uc6a9 4\uac1c\uc6d4 \ud6c4\ubd80\ud130 \uce58\ub8cc\ud6a8\uacfc\uac00 \ub098\ud0c0\ub098\uae30 \uc2dc\uc791\ud588\ub2e4. \uadf8\ub7ec\ub2e4\uac00 2\ub2ec \ud6c4 \uc885\uc591\uc774 \ub2e4\uc2dc \ucee4\uc838 \ucc98\uc74c \uac83\ubcf4\ub2e4\ub3c4 \ub354 \ucee4\uc9c0\ub294 \uc99d\uc0c1\uc774 \uad00\ucc30\ub410\ub294\ub370, \uc774\uac83\uc740 \uc2e4\uc81c \uc554 \uc885\uc591\uc774 \uc544\ub2c8\ub77c \uc554\uc774 \uce58\ub8cc\ub418\uba70 \uc5fc\uc99d\ubc18\uc751\uc5d0 \uc758\ud55c \ubd80\uc885\uc778 \uac83\uc73c\ub85c \ub4dc\ub7ec\ub0ac\ub2e4. \uc774\ub7f0 \ud604\uc0c1\uc740 \ub2e4\ub978 \uc885\ub958\uc758 \uc554\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c\ub3c4 \uc790\uc8fc \ub098\ud0c0\ub0ac\ub2e4. \uae30\uc874 \uc5f0\uad6c\ub294 \uc885\uc591\uc744 \uacc4\uc18d \uc904\uc774\ub294 \uac83\uc5d0\ub9cc \ucd08\uc810\uc744 \ub9de\ucdc4\uc5c8\uae30 \ub54c\ubb38\uc5d0 \uc2e4\ud5d8 \ub2f9\uc2dc (\uc774\uac8c \uc9c4\uc9dc \uce58\ub8cc\uac00 \ub418\ub294 \uac83\uc778\uc9c0\uc5d0 \ub300\ud55c) \ud63c\ub780\uc744 \uc57c\uae30\ud558\uae30\ub3c4 \ud588\ub2e4.”<\/p>\n

-“\ucd5c\uc885\uc801\uc73c\ub85c\u00a0CTLA<\/span>-4\uc640\u00a0PD<\/span>-1\uc744 \ubcf5\ud569\uc801\uc73c\ub85c \uc0ac\uc6a9\ud55c \uc554 \uce58\ub8cc \uc5f0\uad6c\uac00 \uc774\ub904\uc84c\ub2e4. \uadf8 \uacb0\uacfc, \uae30\uc874\uc758 \uce58\ub8cc\ubc95\uc740 \uc554 \ubc1c\ubcd1 \ud6c4 2\ub144 \uc774\uc0c1 \uc9c0\ub098\uba74 \uc0dd\uc874\uc728\uc774 10% \uc544\ub798\ub85c \ub5a8\uc5b4\uc84c\uc9c0\ub9cc,\u00a0CTLA<\/span>-4\uc640\u00a0PD<\/span>-1\uc744 \ud568\uaed8 \uc0ac\uc6a9\ud588\uc744 \ub54c \uce58\ub8cc 3\ub144 \ud6c4 60% \uc774\uc0c1\uc774 \uc0dd\uc874\ud55c \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4. \uc774 \uc5f0\uad6c\ub85c \uc778\ud574 \uc554 \uce58\ub8cc\ub294 \uc0c8\ub85c\uc6b4 \ub2e8\uacc4\uc5d0 \uc811\uc5b4\ub4e4\uc5c8\ub2e4.”<\/p>\n

 <\/p>\n

<\/span><\/p>\n

\uc218\uc0c1\uc790\ub97c \uc120\uc815\ud55c \ub178\ubca8\uc704\uc6d0\ud68c\uc5d0\uc11c \ud604\uc7a5 \ucde8\uc7ac\uc9c4\uc758 \uc9c8\ubb38\uc5d0 \ub300\ud574 \ub2f5\ubcc0\ud558\uace0 \uc788\ub2e4.<\/em><\/span><\/p>\n

 <\/p>\n

\uc544\ub798\ub294 \ub178\ubca8\uc704\uc6d0\ud68c \uc804\ubb38\uac00\ub4e4\uacfc \uc5b8\ub860\uc758 \uc77c\ubb38\uc77c\ub2f5.<\/p>\n

-\uc554\uc5d0 \ub300\ud55c \uc5f0\uad6c\uac00 \ub9ce\uc740\ub370 \uc65c \uc774 \uc5f0\uad6c\uac00 \ub178\ubca8\uc0c1\uc744 \ubc1b\uc558\ub098.<\/p>\n

\u201c\uae30\uc874\uc758 \uc554 \uc5f0\uad6c\uac00 \uc885\uc591 \uadf8 \uc790\uccb4\uc5d0\ub9cc \uc911\uc810\uc744 \ub450\uace0 \uc5f0\uad6c\ub97c \ud588\ub2e4\uba74, \uc774 \ub450 \uc5f0\uad6c\ub294 \uba74\uc5ed\uacc4 \uc804\ubc18\uc744 \ub300\uc0c1\uc73c\ub85c \ud558\uace0 \uc788\ub2e4. \ub610\ud55c \ud55c \uc885\ub958\uc758 \uc554 \uc885\uc591\uc774 \uc544\ub2cc \uc11c\ub85c \ub2e4\ub978 \uc885\ub958\uc758 \uc554 \uc885\uc591\uc744 \ud0c0\uac9f\uc73c\ub85c \ud558\uace0 \uc788\ub2e4.\u201d<\/p>\n

– \uc774\uc804 \uc554 \uc5f0\uad6c\uc640 \ub2e4\ub978 \uc810\uc740 \ubb34\uc5c7\uc778\uac00?<\/p>\n

\u201c\uc554\uc744 \uce58\ub8cc\ud558\uae30 \uc704\ud55c \uc5f0\uad6c\ub97c \ud06c\uac8c \ub450 \uadf8\ub8f9\uc73c\ub85c \ub098\ub20c \uc218 \uc788\ub2e4. \uae30\uc874\uc758 \uc5f0\uad6c\ub294 \uc790\uadf9\uc5d0 \uc758\ud55c \uce58\ub8cc\ubc95\uc774\ub2e4. \ubc18\uba74 \uc624\ub298 \ubc1c\ud45c\ub41c \uc5f0\uad6c\ub294 \uc554 \uc885\uc591\uc744 \ucabc\uac1c\uac70\ub098 \ub2e4\ub978 \ucda9\uaca9\uc744 \uac00\ud558\uc9c0 \uc54a\uace0, \uad6c\uc870\uc801\uc778 \uc6d0\ub9ac\ub97c \uaddc\uba85\ud588\ub2e4. \uce58\ub8cc\uc5d0 \ub300\ud55c \ud6a8\uacfc\ub3c4 \uc88b\uc558\uace0, \ud3d0\uc554, \uc2e0\uc7a5\uc554 \ub4f1 \uc5ec\ub7ec \uc885\ub958\uc758 \uc554\uc5d0 \uadf8 \ud6a8\uacfc\uac00 \uc788\ub2e4.<\/p>\n

-\uc774 \ud56d\uc554\uc81c\ub294 \ubd80\uc791\uc6a9\uc774 \uc5c6\ub294\uac00?<\/p>\n

\u201c\uba87 \uac00\uc9c0 \ubd80\uc791\uc6a9\uc774 \uc788\uc5c8\uc9c0\ub9cc, \uc774\ub294 \ub2e4\uc2dc \uc6d0\uc0c1\ud0dc\ub85c \ub418\ub3cc\ub9b4 \uc218 \uc788\ub294 \ubd80\uc791\uc6a9\uc774\uc5c8\ub2e4. \uadf8\ub9ac\uace0 \ubd80\uc791\uc6a9\ubcf4\ub2e4\ub3c4 \uc774\uc775\uc774 \ub354 \ub9ce\uc73c\uba70, \ud604\uc7ac \uc788\ub294 \ubd80\uc791\uc6a9\uc744 \uc5c6\uc560\uae30 \uc704\ud574 \uc9c0\uae08\ub3c4 \uc5f0\uad6c \uc911\uc5d0 \uc788\ub2e4.\u201d<\/p>\n

-\ubbf8\ub798 \ud56d\uc554\uce58\ub8cc \ubc29\ud5a5\uc740?<\/p>\n

\u201c\uc5ec\ud0dc\uae4c\uc9c0\uc758 \uc5f0\uad6c\ub4e4\uc744 \ubcf5\ud569\ud558\ub294 \uac83, \uadf8\ub9ac\uace0 \uc774\uac83\ub4e4\uc744 \uc774\uc6a9\ud574 \ud658\uc790 \uac1c\uac1c\uc778\uc5d0 \ub9de\uac8c \ub9de\ucda4\uce58\ub8cc\ub97c \ud558\ub294 \ubc29\ud5a5\uc73c\ub85c \ub098\uc544\uac08 \uac83\uc73c\ub85c \ubcf4\uc778\ub2e4.\u201d<\/p>\n

-\uc218\uc0c1\uc790\ub4e4\uc758 \uc18c\uac10\uc744 \ub4e3\uace0\uc2f6\uc740\ub370.<\/p>\n

\u201c\uc568\ub9ac\uc2a8 \uad50\uc218\ub294 \uc5f0\uacb0\uc774 \ub418\uc9c0 \uc54a\uc558\ub2e4. \ud63c\uc870 \uad50\uc218\ub294 \uc804\ud654\ub85c \u2018\ub9e4\uc6b0 \uae30\uc058\ub2e4\u2019\uace0 \uc804\ud574\uc654\ub2e4.\u201d<\/p>\n

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http:\/\/m.medigatenews.com\/news\/2451113259<\/p>\n

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\uc62c\ud574 \ub178\ubca8\uc0dd\ub9ac\uc758\ud559\uc0c1\uc740 \ub204\uac00 \ubc1b\uc744\uae4c?<\/h5>\n
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\uba74\uc5ed\ud56d\uc554\uc81c \uac1c\ucc99\uc790 \uc81c\uc784\uc2a4 \uc568\ub9ac\uc2a8 \ubc15\uc0ac \uae30\ub300<\/p>\n<\/div>\n

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\"\"
\uc0ac\uc9c4: \uc81c\uc784\uc2a4 \uc568\ub9ac\uc2a8(James Allison)\u00a0\ubc15\uc0ac (\ucd9c\ucc98: Wikipedia)<\/figcaption><\/figure>\n

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\ud574\ub9c8\ub2e4 10\uc6d4\uc774\uba74 \ub178\ubca8\uc0c1\uc744 \uc8fc\uad00\ud558\ub294 \uc2a4\uc6e8\ub374 \uc655\ub9bd\uacfc\ud559\uc544\uce74\ub370\ubbf8\uc640 \ub178\ub974\uc6e8\uc774 \ub178\ubca8\uc704\uc6d0\ud68c\uac00 \ub178\ubca8\uc0c1 \uc218\uc0c1\uc790\ub97c \ubc1c\ud45c\ud55c\ub2e4.<\/p>\n

2017\ub144 \uc62c\ud574 \ub178\ubca8 \uc0dd\ub9ac\uc758\ud559\uc0c1\uc740 \ub204\uac00 \ubc1b\uc744\uae4c? \uc774\uc81c 7\uc6d4\uc774\uc9c0\ub9cc \ube68\ub9ac \uc2dc\uc6d0\ud55c \uac00\uc744\uc774 \uc654\uc73c\uba74 \ud558\ub294 \ubc14\ub78c\uc5d0\uc11c \ubbf8\ub9ac \uc0dd\uac01\ud574 \ubcf4\uc558\ub294\ub370, \uc544\ubb34\ub798\ub3c4 \ud604\uc7ac \uc5e0\ub514 \uc564\ub354\uc2a8(MD Anderson) \uc554\uc13c\ud130\uc5d0\uc11c \uba74\uc5ed\ud559 \ubd80\ubd84\uc744 \uc774\ub044\ub294 \uc81c\uc784\uc2a4 \uc568\ub9ac\uc2a8 (James Allison) \ubc15\uc0ac\uac00 \ubc1b\uc9c0 \uc54a\uc744\uae4c \uc608\uc0c1\ud55c\ub2e4. \uc568\ub9ac\uc2a8 \ubc15\uc0ac\ub294 “\uba74\uc5ed\uacc4\uc758 \ud575\uc2ec\uc801\uc778 \ubd84\uc790 \ube0c\ub808\uc774\ud06c \uc2dc\uc2a4\ud15c\uc744 \uc5b5\uc81c\ud568\uc73c\ub85c\uc368, \uba74\uc5ed\uacc4\uc758 \uc554 \uc0b4\uc0c1\ub2a5\ub825\uc744 \uc99d\uac15\uc2dc\ud0ac \uc218 \uc788\ub2e4”\ub294 \uc0ac\uc2e4\uc744 25\ub144\uc5d0 \uac78\uccd0 \uc785\uc99d\ud574 \uc654\ub2e4.<\/p>\n

\ud574\ub2f9 \ubd84\uc57c\uc5d0 \uc788\uc5b4\uc11c\uc758 \ud68d\uae30\uc801\uc778 \uacfc\ud559\uc801 \ubc1c\uacac\uacfc \uadf8 \ubc1c\uacac\uc758 \uc0ac\ud68c\uc801 \uacf5\ud5cc\ub3c4\ub97c \uc0b4\ud3b4\ubcf4\ub294 \uac83 \uc678\uc5d0 \uc774\ub807\uac8c \ub178\ubca8\uc0c1 \uc218\uc0c1\uc744 \uc810\uce60 \uc218 \uc788\ub294 \uac83 \uc911\uc5d0 \ud558\ub098\ub294 \ub808\uc2a4\ucee4\uc0c1\uc758 \uc218\uc0c1 \uc720\ubb34\uc774\ub2e4.<\/p>\n

\uc131\uacf5\ud55c \uad11\uace0\uae30\uc5c5\uc778\uc774\uc790 \uc790\uc120\uc0ac\uc5c5\uac00\ub85c \uac74\uac15\u00b7\uc758\ub8cc \uc5f0\uad6c \uc99d\uc9c4\uc5d0 \uad00\uc2ec\uc774 \ub9ce\uc558\ub358 \uc568\ubc84\ud2b8 \ub798\uc2a4\ucee4\uc640 \uadf8\uc758 \uc544\ub0b4 \uba54\ub9ac \ub798\uc2a4\ucee4\uac00 \uc124\ub9bd\ud55c \uc774 \uc0c1\uc740 ‘\ubbf8\uad6d\uc758 \ub178\ubca8\uc0c1’\uc73c\ub85c \ubd88\ub9ac\uae30\ub3c4 \ud558\ub294\ub370, 1945\ub144\ubd80\ud130\u00a0\ud55c \ud574\uc5d0 \ud55c \ucc28\ub840 \uc758\ud559 \ubd84\uc57c\uc5d0 \ud070 \uae30\uc5ec\ub97c \ud55c \uc774\uc5d0\uac8c(\ud604\uc7ac \uc0dd\uc874\uc790\uc5d0 \ud55c\ud574) \uc218\uc5ec\ud558\ub294 \uc0c1\uc774\ub2e4. \uc9c0\uae08\uae4c\uc9c0 86\uba85\uc758 \ub798\uc2a4\ucee4 \uc218\uc0c1\uc790\ub4e4\uc774 \ub178\ubca8\uc0c1\uc744 \ubc1b\uc558\uc73c\uba70, \uc774 \uc911 32\uba85\uc740 \uc9c0\ub09c 20\ub144 \ub0b4\uc5d0 \uc218\uc0c1\ud558\uc600\ub2e4.<\/p>\n

\uc81c\uc784\uc2a4 \uc568\ub9ac\uc2a8 \ubc15\uc0ac\ub294 2015\ub144 \ub798\uc2a4\ucee4\uc0c1(\uc784\uc0c1\uc758\ud559 \uc5f0\uad6c\ubd80\ubb38)\uc744 \uc218\uc0c1\ud558\uc600\ub294\ub370, \uba74\uc5ed \ud56d\uc554\uc81c\ub77c\ub294 \uc0c8\ub85c\uc6b4 \uc601\uc5ed\uc744 \uac1c\ucc99\ud558\uc5ec \uc554\ud658\uc790\uc5d0 \ub300\ud55c \uce58\ub8cc \ud6a8\uacfc\ub97c \ud5a5\uc0c1\uc2dc\ud0a8 \uacf5\ub85c\ub97c \uc778\uc815\ubc1b\uc558\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n

\uc804\ud1b5\uc801\uc778 \uc554 \uce58\ub8cc\ubc95\uc740 \uc57d\ubb3c\uc744 \uc774\uc6a9\ud558\uc5ec \uc554\uc744 \ucd08\ub798\ud55c \ub3cc\uc5f0\ubcc0\uc774\ub97c \uacf5\uaca9\ud558\ub294 \uac83\uc774\ub2e4. \uc774\ub294 \uc88b\uc740 \ubc29\ubc95\uc774\uae30\ub294 \ud558\uc9c0\ub9cc, \uc885\uc591\uc774 \uc57d\ubb3c\uc5d0 \ub300\ud574 \uc800\ud56d\uc131\uc744 \uac16\uac8c \ub418\ub294 \ub4f1\uc758 \ubb38\uc81c\uc810\uc744 \uac00\uc9c0\uace0 \uc788\ub2e4. \uba74\uc5ed\uc694\ubc95, \ud2b9\ud788 \uba74\uc5ed\uad00\ubb38 \uc5b5\uc81c\uc694\ubc95(checkpoint blockade therapy)\uc740 \uba87 \uac00\uc9c0 \uc810\uc5d0\uc11c \uc804\ud1b5\uc801 \uc554\uce58\ub8cc\ubc95\uacfc \ub2e4\ub974\ub2e4.<\/p>\n

\uccab\uc9f8, \uba74\uc5ed\uc694\ubc95\uc740 \uba74\uc5ed\uacc4\ub85c \ud558\uc5ec\uae08 \uc554\uc744 \uacf5\uaca9\ud558\uac8c \ud558\uba70, \ud2b9\ud788 \uba74\uc5ed\uad00\ubb38 \uc5b5\uc81c\uc694\ubc95\uc740 T\uc138\ud3ec\ub85c \ud558\uc5ec\uae08 \uc885\uc591\uc744 \uacf5\uaca9\ud558\uac8c \ud55c\ub2e4. T\uc138\ud3ec\ub294 \uc138\ud3ec \ud45c\uba74\uc5d0\uc11c \ub3cc\uc5f0\ubcc0\uc774\ub098 \uc678\ubd80\uc5d0\uc11c \uc720\uc785\ub41c \ud3a9\ud0c0\uc774\ub4dc\ub97c \ud0d0\uc9c0\ud558\ub294\ub370, \uba74\uc5ed\uad00\ubb38 \uc5b5\uc81c\uc694\ubc95\uc73c\ub85c \uce58\ub8cc\ubc1b\uc740 T\uc138\ud3ec\ub294 \uc0c8\ub85c\uc6b4 \ub3cc\uc5f0\ubcc0\uc774\ub97c \uc778\uc2dd\ud558\uac8c \ub41c\ub2e4.<\/p>\n

\ub458\uc9f8, \uc801\uc751\uc131(adaptability)\uc774\ub2e4. \uc778\uac04\uc758 \uba74\uc5ed\uacc4\ub294 \ub3d9\uc801 \uc2dc\uc2a4\ud15c\uc774\ubbc0\ub85c, \uc885\uc591\uc774 \ubcc0\ud654\ud560 \uacbd\uc6b0 \uba74\uc5ed\uacc4\ub3c4 \ub530\ub77c\uc11c \ubcc0\ud654\ud55c\ub2e4. \uc885\uc591\uc774 \uacf5\uaca9\uc744 \ubc1b\uc544 \uc8fd\uc744 \ub54c \ub610 \ub2e4\ub978 \ud56d\uc6d0\uc744 \ub9cc\ub4e4\uc5b4\ub0b4\uc9c0\ub9cc T\uc138\ud3ec\uc640 B\uc138\ud3ec\ub294 \uc0c8\ub85c\uc6b4 \ud56d\uc6d0\uc744 \uacf5\uaca9\ud560 \uc218 \uc788\ub294 \uc138\ud3ec\uad70\ub4e4\uc744 \ub354 \ub9cc\ub4e4\uc5b4\ub0b4\ub294 \uc801\uc751\ub825\uc744 \ubc1c\ud718\ud55c\ub2e4.<\/p>\n

\ud654\ud559\uc694\ubc95\uc774\ub098 \ubc29\uc0ac\uc120\uc694\ubc95\uacfc \ube44\uad50\ud558\uc5ec \uc138 \ubc88\uc9f8 \ucc28\uc774\uc810\uc740 T\uc138\ud3ec\ub294 \uc790\uccb4\uc758 \u201c\uae30\uc5b5(memory)\u201d \uae30\ub2a5\uc774\ub2e4. \ud2b9\ubcc4\ud788 \uc554\uc138\ud3ec\uc5d0\uc11c \uc720\ub798\ub418\uac70\ub098 \ubcc0\ud615\ub41c \ub3cc\uc5f0\ubcc0\uc774\ub97c T\uc138\ud3ec\ub97c \ud1b5\ud574 \uae30\uc5b5\uc744 \uacc4\uc18d \ubcf4\uc720\ud558\ubbc0\ub85c, \ud5a5\ud6c4\uc5d0 \uc885\uc591\uc774 \ub2e4\uc2dc \ubc1c\uc0dd\ud560 \ub54c \uae30\uc5b5\uc744 \uc720\uc9c0\ud558\uace0 \uc788\ub294 T\uc138\ud3ec\ub97c \ub3d9\uc6d0\ud558\uc5ec \uc885\uc591\uc744 \uacf5\uaca9\ud558\uac8c \ub41c\ub2e4.<\/p>\n

\uc0ac\uc2e4, ‘\uba74\uc5ed\uacc4\ub97c \uc774\uc6a9\ud558\uc5ec \uc554\uc744 \uce58\ub8cc\ud560 \uc218 \uc788\ub2e4’\ub294 \uc774\ub860\uc744 \ucc98\uc74c \uc81c\uae30\ud55c \uc778\ubb3c\uc740 \ud3f4 \uc5d0\ub97c\ub9ac\ud788(Paul Ehrlich)\uc774\ub2e4. 1909\ub144 \uc5d0\ub97c\ub9ac\ud788\ub294 “\uba74\uc5ed\uacc4\uac00 \ud56d\uccb4\ub97c \ubcf4\uc720\ud558\uace0 \uc788\uc5b4\uc11c, \uc885\uc591\uc744 \uc81c\uac70\ud560 \uc218 \uc788\ub2e4”\uace0 \uc0dd\uac01\ud588\ub2e4. \uadf8\ub7ec\ub098 ‘\uc5b4\ub5a4 \ud56d\uccb4\ub97c \uc774\uc6a9\ud560 \uac83\uc778\uac00?’\uac00 \ubb38\uc81c\uc600\ub2e4.<\/p>\n

\uc568\ub9ac\uc2a8 \ubc15\uc0ac\ub294 1990\ub144\ub300 \uc911\ubc18\ubd80\ud130 25\ub144 \ub3d9\uc548 \uac70\uc758 ‘CTLA-4’\ub77c\ub294 \ub2e8\ubc31\uc9c8, \uc989 ‘T \uc138\ud3ec\uc5d0 \uc788\ub294 \ud56d\uc6d04’\uc744 \uc911\uc810\uc801\uc73c\ub85c \uc5f0\uad6c\ud558\uc600\ub2e4. \uc774 \ub2e8\ubc31\uc9c8\uc740 T\uc138\ud3ec\uc758 \ud65c\uc131\uc758 \uac15\uc57d\uc744 \uc870\uc808\ud558\ub294 \uc5ed\ud560\uc744 \ud55c\ub2e4. \uc568\ub9ac\uc2a8\uc740 ‘CTLA-4’\uc5d0 \ube0c\ub808\uc774\ud06c\ub97c \uac70\ub294 ‘Anti-CTLA-4’ \ub2e8\ud074\ub860\ud56d\uccb4\ub97c \ub9cc\ub4e4\uc5b4 \ud65c\uc131\uc744 \ucc28\ub2e8\ud568\uc73c\ub85c\uc368, T\uc138\ud3ec\uc758 \uc554 \uc0b4\uc0c1\ub825\uc744 \uc99d\uac15\uc2dc\ud0a4\ub294 \ubc29\ubc95\uc744 \ubc1c\uacac\ud558\uc600\ub2e4.<\/p>\n

\uadf8\ub294 \uc774 \uc0c8\ub85c\uc6b4 \uc554 \uce58\ub8cc\ubc95\uc744 \uac1c\ubc1c\ud558\ub294 \ub370 \ud601\ud601\ud55c \uacf5\uc744 \uc138\uc6e0\uace0, 2011\ub144 \uc5ec\ubcf4\uc774(Yervoy)\uac00 \uba74\uc5ed \ud56d\uc554\uc81c\ub85c FDA\uc758 \uc2b9\uc778 \ud5c8\uac00\ub97c \ubc1b\uc558\ub2e4. \ud2b9\ud788 \ud3c9\uade0 \uae30\ub300\uc218\uba85\uc774 1\ub144 \ubbf8\ub9cc\uc778 \uc804\uc774\uc131 \ud751\uc0c9\uc885\uc744 \uc5ec\ubcf4\uc774\ub85c \uce58\ub8cc\ud55c \uacbd\uc6b0 \ud658\uc790\uc758 \uc218\uba85\uc744 \ubb34\ub824 10\ub144\uc774\ub098 \uc5f0\uc7a5\uc2dc\ud0a4\ub294 \uac83\uc744 \uc785\uc99d\ud55c \ubc14 \uc788\ub2e4.<\/p>\n

\uc5ec\ubcf4\uc774\ub97c \uc2dc\uc791\uc73c\ub85c \ud558\uc5ec 2014\ub144 \ud6c4\ubc18 \uac70\uc758 \ub3d9\uc2dc\uc5d0 \ud5c8\uac00\ub97c \ubc1b\uc740 PD-1 \uc5b5\uc81c\uc81c, \ud0a4\ud2b8\ub8e8\ub2e4(Keytruda)\uc640 \uc635\ud2f0\ubcf4(Opdivo), 2016\ub144 \ud5c8\uac00\ub97c \ubc1b\uc740 PD-L1\uc744 \uc5b5\uc81c\ud558\ub294 \ud2f0\uc13c\ud2b8\ub9ad(Tecentriq) \ub4f1 \uba74\uc5ed\uad00\ubb38 \uc5b5\uc81c\uc81c\ub4e4\uc740, \uc554\ud658\uc790\uc758 \uc0b6\uc758 \uc9c8\uc744 \ub208\uc5d0 \ub744\uac8c \uac1c\uc120\uc2dc\ud0a8\ub2e4. \uadf8\ub7ec\ubbc0\ub85c \uba74\uc5ed \ud56d\uc554\uc81c\uc758 \uacbd\uc81c\uc801 \uac00\uce58\ub294 \ube44\uc2fc \ube44\uc6a9\uc744 \ud6e8\uc52c \uc0c1\ud68c\ud558\uba70 \ud654\ud559\uc694\ubc95\uc5d0 \ube44\ud560 \ubc14\uac00 \uc544\ub2c8\ub2e4.<\/p>\n

\uba74\uc5ed \ud56d\uc554\uc81c\uac00 \uc544\uc9c1 \ubaa8\ub4e0 \ud658\uc790\ub97c \uce58\ub8cc\ud560 \uc218\ub294 \uc5c6\uc9c0\ub9cc, \ub2e4\ub978 \uce58\ub8cc\ubc95\ubcf4\ub2e4 \ud6e8\uc52c \ub354 \ud6a8\uacfc\uc801\uc774\ub77c\ub294 \uac83\ub9cc\uc740 \ubd84\uba85\ud558\ub2e4. \ub9ce\uc740 \uc784\uc0c1\uc744 \ud1b5\ud558\uc5ec \uba74\uc5ed \ubc18\uc751\uc744 \uac15\ud654\uc2dc\ucf1c \uc554\uc744 \uce58\ub8cc\ud560 \uc218 \uc788\uc74c\uc744 \uc785\uc99d\ud558\uc600\uace0 \ub2e4\ub978 \ud56d\uc554\uc81c\uc640 \ubcd1\uc6a9 \ud22c\uc5ec\ub97c \ud1b5\ud558\uc5ec \uba74\uc5ed \ud56d\uc554\uc81c\uc758 \ud6a8\uc6a9\uc131\uc774 \uc99d\uba85\ub418\uace0 \uc788\ub294 \uac83\uc740 \ub9e4\uc6b0 \uace0\ubb34\uc801\uc774\ub2e4.<\/p>\n

\uba74\uc5ed \ud56d\uc554\uc81c\uc640 \uae30\uc874 \ud56d\uc554 \uce58\ub8cc\uc81c\uc758 \ubcd1\uc6a9 \ud22c\uc5ec \ubc29\ubc95\uc73c\ub85c \uc870\ub9cc\uac04 \ub300\ub2e4\uc218\uc758 \uc554\uc744 \uce58\ub8cc\ud560 \uc218 \uc788\uc73c\ub9ac\ub77c \uc0dd\uac01\ud55c\ub2e4. \uc774\ub7ec\ud55c \uc774\uc720\ub85c, \uba74\uc5ed \ud56d\uc554\uc81c\uc758 \uac1c\ucc99\uc790\uc778 \uc81c\uc784\uc2a4 \uc568\ub9ac\uc2a8 \ubc15\uc0ac\uac00 \uc774\ubc88 \uac00\uc744\uc5d0 \ub178\ubca8\uc0c1\uc744 \ubc1b\uc744 \uac83\uc774\ub77c\uace0 \uc608\uc0c1\ud558\ub294 \uac83\uc740 \uadf8\ub9ac \uc5b4\ub824\uc6b4 \uc77c\uc774 \uc544\ub2c8\ub2e4.<\/p>\n

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http:\/\/m.kpanews.co.kr\/article\/show.asp?table=column_youth&idx=458<\/p>\n

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\uc554\uce58\ub8cc\uc758 \ud328\ub7ec\ub2e4\uc784\uc744 \ubc14\uafbc 3\uc138\ub300 \uc554 \uce58\ub8cc\uc81c- \uba74\uc5ed\ud56d\uc554\uc81c<\/h5>\n

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\ucd5c\uadfc \uc554 \uce58\ub8cc\uc5d0 \uc788\uc5b4 \uac00\uc7a5 \ud56b\ud55c \uc774\uc288\uc778 ‘\uba74\uc5ed\ud56d\uc554\uc81c(immune checkpoint inhibitor)’\uc5d0 \ub300\ud574 \uc54c\uc544\ubcf4\uace0\uc790 \ud55c\ub2e4.<\/p>\n

\uba74\uc5ed\ud56d\uc554\uc81c\ub780 \uac04\ub2e8\ud788 \ub9d0\ud574 \uc6b0\ub9ac\uac00 \uac00\uc9c0\uace0 \uc788\ub294 \uace0\uc720\uc758 \uba74\uc5ed\uacc4\ub97c \uac15\ud654\uc2dc\ucf1c \uc554\uacfc \uc2f8\uc6b0\ub294 \ud798\uc744 \uae38\ub7ec\uc8fc\ub294 \uc57d\ubb3c\uc774\ub2e4. \uc6b0\ub9ac\uac00 \uac00\uc9c4 \ubcf8\uc5f0\uc758 \ud798\uc73c\ub85c \uc554\uc744 \uc800\uc9c0\ud55c\ub2e4\ub294 \uc810\uc5d0\uc11c \uc9c0\uae08\uae4c\uc9c0\uc758 \uc554\uce58\ub8cc\ub97c \ubc14\ub77c\ubcf4\ub294 \uac1c\ub150\uacfc \uadfc\ubcf8\uc801\uc778 \ucc28\uc774\uac00 \uc788\ub2e4.<\/p>\n

\ubcf8\ub798 \uc554\uc138\ud3ec\ub294 T\uc138\ud3ec\uc758 ‘PD-1’, ‘PD-L1’, ‘CTLA-4’ \ub4f1\uc758 \uba74\uc5ed \uccb4\ud06c\ud3ec\uc778\ud2b8 \ub2e8\ubc31\uc9c8(\uba74\uc5ed\uad00\ubb38)\uacfc \uacb0\ud569\ud568\uc73c\ub85c\uc368 \uba74\uc5ed \ud68c\ud53c \uc2e0\ud638\ub97c \ubcf4\ub0b4\uc5b4 T\uc138\ud3ec\uc758 \uc554\uc138\ud3ec \uacf5\uaca9\uc744 \ud68c\ud53c\ud55c\ub2e4.<\/p>\n

\uba74\uc5ed\ud56d\uc554\uc81c\ub294 \uc554\uc138\ud3ec\uc640 T\uc138\ud3ec\uc758 \uacb0\ud569 \ubd80\uc704\uc5d0 \uacb0\ud569\ud558\uc5ec \uba74\uc5ed\ud68c\ud53c \uc2e0\ud638\ub97c \ucc28\ub2e8\ud568\uc73c\ub85c\uc368 \uba74\uc5ed\ud559\uc801 \uc2dc\ub0c5\uc2a4\uac00 \ud615\uc131\ub418\uc9c0 \ubabb\ud558\uace0, \uc774\uc5d0 \ub530\ub77c \uba74\uc5ed\ud68c\ud53c \ubc29\ud574\ub97c \ubc1b\uc9c0 \uc54a\ub294 T\uc138\ud3ec\uac00 \uc554\uc138\ud3ec\ub97c \ud30c\uad34\ud558\ub294 \uba54\ucee4\ub2c8\uc998\uc744 \ud1b5\ud574 \uc554\uc744 \uce58\ub8cc\ud55c\ub2e4.<\/p>\n

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T\uc138\ud3ec\ub294 \uc554\uc138\ud3ec\uc5d0\uc11c \ubc1c\ud604\ud558\ub294 \ud56d\uc6d0\uc744 \ud655\uc778\ud574 \uc554\uc138\ud3ec\ub97c \uacf5\ub7b5\ud560 \uc218 \uc788\ub294\ub370 \uc774\uac83\uc774 \uc81c\ub300\ub85c \ud65c\ub3d9\ud560 \uc218 \uc788\ub3c4\ub85d \ud568\uc73c\ub85c\uc368 \uc9c0\uc18d\uc801\uc778 \ud56d\uc554\ud6a8\uacfc\ub97c \uaf80\ud55c \uac83\uc774\ub2e4.<\/p>\n

\ub355\ubd84\uc5d0 \uba74\uc5ed\ud56d\uc554\uc81c\ub294 \ub04a\uc784\uc5c6\ub294 \uc554\uc138\ud3ec\uc758 \ubcc0\ud654\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \uc9c0\uc18d\uc801\uc778 \ud56d\uc554\ud6a8\uacfc\ub97c \ub098\ud0c0\ub0b4\uc5b4 \uc554 \uce58\ub8cc \ud6a8\uacfc\ub97c \ub192\uc77c \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uae30\ub300\ub41c\ub2e4.<\/p>\n

\uba74\uc5ed\ud56d\uc554\uc81c\ub294 \uae30\uc874\uc758 \uc554 \uce58\ub8cc\ubc95\uc758 \ub2e8\uc810\uc744 \ubcf4\uc644\ud558\uc600\ub2e4. 1\uc138\ub300 \ud654\ud559\ud56d\uc554\uc81c\ub294 \uc554\uc138\ud3ec\ub97c \uc9c1\uc811 \uacf5\uaca9\ud558\uace0, 2\uc138\ub300 \ud45c\uc801 \ud56d\uc554\uc81c\ub294 \uc554 \uad00\ub828 \uc720\uc804\uc790\ub97c \uacf5\uaca9\ud558\ub294 \uae30\ub2a5\uc744 \ud55c\ub2e4\uba74 3\uc138\ub300 \ud56d\uc554\uc81c\ub77c \ubd88\ub9ac\ub294 \uba74\uc5ed\ud56d\uc554\uc81c\ub294 \uba74\uc5ed\ub825\uc744 \uac15\ud654\ud574 \uc554\uc744 \uce58\ub8cc\ud558\uac8c \ub41c\ub2e4.<\/p>\n

\ubc29\uc0ac\uc120 \uc694\ubc95\uc774\ub098 \ud56d\uc554\uc81c \ub4f1 \uc9c1\uc811\uc801\uc73c\ub85c \uc554\uc138\ud3ec\ub97c \uacf5\uaca9\ud558\ub294 \uae30\uc874 \uce58\ub8cc\ubc95\uc774\ub098 \uc57d\ubb3c\uacfc \ub2ec\ub9ac \ud658\uc790\uc758 \uba74\uc5ed\ub825 \uac15\ud654\ub97c \ud1b5\ud574 \uc554\uc744 \uce58\ub8cc\ud558\uae30 \ub54c\ubb38\uc5d0 \uba74\uc5ed\ud56d\uc554\uc81c\ub294 \ud56d\uc554\ubd80\uc791\uc6a9\uc744 \ucd5c\uc18c\ud654\ud558\uace0 \uba74\uc5ed\ub825\uc744 \ub192\uc77c \uc218 \uc788\ub294 \uce58\ub8cc\ubc95\uc73c\ub85c \uc8fc\ubaa9\ubc1b\uace0 \uc788\ub2e4.<\/p>\n

\uae30\uc874\uc758 \ud654\ud559 \ud56d\uc554\uce58\ub8cc\ubc95\uc740 \uc554 \uc138\ud3ec\ub97c \uc0ac\uba78\ud558\uae30 \uc704\ud574 \uc815\uc0c1\uc138\ud3ec\uae4c\uc9c0 \ubb34\ucc28\ubcc4\ud558\uac8c \uacf5\uaca9\ud558\uc5ec \ud658\uc790\uc758 \uba74\uc5ed\uccb4\uacc4\ub97c \ubb34\ub108\ud2b8\ub9ac\uace0 \ud56d\uc554 \uce58\ub8cc\uc81c\uc758 \uac15\ud55c \ub3c5\uc131\uc73c\ub85c \uc778\ud574 \ud0c8\ubaa8, \uad6c\ud1a0, \uc2dd\uc695\uc800\ud558, \ud53c\ub85c\uac10, \uadf9\uc2ec\ud55c \uccb4\ub825\uc800\ud558 \ub4f1 \uac01\uc885 \ubd80\uc791\uc6a9\uc774 \uc788\uc5c8\ub2e4.<\/p>\n

\uba74\uc5ed\ud56d\uc554\uc81c\ub294 \ud658\uc790 \uc2a4\uc2a4\ub85c\uc758 \uba74\uc5ed\uac15\ud654\ub97c \ud1b5\ud574 \uce58\ub8cc\ub97c \ud55c\ub2e4\ub294 \uc810\uc5d0\uc11c \uc774\ub7ec\ud55c \ubd80\uc791\uc6a9\uc774 \uc801\uace0 \uc554 \ud658\uc790\uc758 \uc0b6\uc758 \uc9c8\uc744 \ub192\uc774\uace0 \uc0dd\uc874\uae30\uac04\ub3c4 \ub300\ud3ed \uc5f0\uc7a5\ub418\ub294 \ud6a8\uacfc\uac00 \uc788\ub2e4.<\/p>\n

\ub610\ud55c \ud45c\uc801\ud56d\uc554\uc81c\ub294 \uc554 \uc138\ud3ec\ub9cc\uc744 \uc2dd\ubcc4\ud574 \uacf5\uaca9\ud558\ub294 \ub2a5\ub825\uc774 \uc788\uc5b4 \uc784\uc0c1 \ud604\uc7a5\uc5d0\uc11c \uac01\uad11 \ubc1b\uc558\uc9c0\ub9cc, \uc801\uc6a9\ud560 \uc218 \uc788\ub294 \uc554\uc758 \uc885\ub958\uac00 \ud55c\uc815\uc801\uc774\uace0 \ub0b4\uc131\uc774 \uc0dd\uae30\ub294 \uacbd\ud5a5\uc774 \uc788\uc5b4 \uc77c\ubc18\uc801\uc73c\ub85c \ud65c\uc6a9\ub418\uae30 \uc5b4\ub824\uc6e0\ub2e4.<\/p>\n

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\uba74\uc5ed\ud56d\uc554\uc81c\ub294 \uba74\uc5ed\uc138\ud3ec\uac00 \uac00\uc9c4 \uc554\uc138\ud3ec \uc2dd\ubcc4 \ub2a5\ub825\uc744 \ud65c\uc6a9\ud558\ubbc0\ub85c \uc554\uc758 \uc885\ub958\uc5d0 \ud06c\uac8c \uad6c\uc560\ubc1b\uc9c0 \uc54a\uace0 \ubcc0\ud654\ubb34\uc30d\ud568 \uc554\uc138\ud3ec\uc5d0 \ub9de\ucdb0 \uc2a4\uc2a4\ub85c \ubb34\uae30\ub97c \ubc14\uafc0 \uc218 \uc788\ub294 \uba74\uc5ed\uc138\ud3ec\ub4e4\uc744 \ud65c\uc6a9\ud568\uc73c\ub85c\uc368 \ubcf4\ub2e4 \ud6a8\uc728\uc801\uc73c\ub85c \uc554\uc138\ud3ec\uc5d0 \ub300\ud56d\ud560 \uc218 \uc788\ub2e4\ub294 \uc7a5\uc810\uc774 \uc788\ub2e4.<\/p>\n

\uadf8\ub7ec\ub098 \uba74\uc5ed\ud56d\uc554\uc81c\uc758 \ud2b9\uc815 \ud0c0\uac9f\uc744 \ubaa9\ud45c\ub85c\ud558\ub294 \uac83\uc774 \uc544\ub2c8\ub77c \uba74\uc5ed\uccb4\uacc4\uac00 \uc2a4\uc2a4\ub85c \uc554\uc138\ud3ec\ub97c \uacf5\uaca9\ud558\ub3c4\ub85d \uc870\ub825\ud558\ub294 \ud2b9\uc131\uc73c\ub85c \uc778\ud574 \ub1cc\uc554\ucc98\ub7fc \ud56d\uccb4\uc758 \uc811\uadfc\uc774 \uc5b4\ub824\uc6b4 \uc554\uc885\uc5d0\uc11c\uc758 \ud6a8\uacfc\ub294 \ubd88\ud655\uc2e4\ud558\ub2e4\ub294 \ud55c\uacc4\uac00 \uc788\ub2e4.<\/p>\n

\uc774\uc678\uc5d0\ub3c4 \uc0c8\ub85c\uc6b4 \uae30\uc804\uc758 \uce58\ub8cc\uc81c\ub2e4 \ubcf4\ub2c8 \uae30\uc874 \uce58\ub8cc\uc81c\uc758 \ud3c9\uac00\ubc29\ubc95\uc744 \uc801\uc6a9\ud558\uae30\uc5d0\ub3c4 \uace0\ubbfc\uc774 \ud06c\ub2e4. \uba74\uc5ed\uc138\ud3ec\uac00 \uc554\uc138\ud3ec\ub97c \uacf5\uaca9\ud558\uae30 \uc704\ud574 \uacb0\ud569\ud558\ub294 \uacfc\uc815\uc5d0\uc11c \uc885\uc591\uc758 \ud06c\uae30\uac00 \uc77c\uc2dc\uc801\uc73c\ub85c \ucee4\uc9c0\uae30\ub294\ub370 \uc885\uc591\uc758 \ud06c\uae30\ub97c \uae30\uc900\uc73c\ub85c \ud55c \ud604\uc7ac\uc758 \ud56d\uc554 \uce58\ub8cc \ud3c9\uac00\ubc29\ubc95\uc740 \uba74\uc5ed\ud56d\uc554\uc81c\uc758 \uce58\ub8cc \ud6a8\uacfc\ub97c \ud655\uc778\ud558\ub294\ub370 \uc0c1\ub2f9\ud788 \ubd88\ub9ac\ud558\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n

\uc774\ub294 \ub300\uc870\uad70\uacfc\uc758 \uc784\uc0c1\uc124\uacc4, \uc801\uc751\uc99d\uc758 \ud5c8\uac00, \uae09\uc5ec\uae30\uc900\uc744 \ud68d\ub4dd\ud558\ub294 \ub370\uc5d0\ub3c4 \ubd88\ub9ac\ud558\uac8c \uc791\uc6a9\ud560 \uac83\uc774\ub2e4.<\/p>\n

\ubfd0\ub9cc \uc544\ub2c8\ub77c \uba74\uc5ed\uae30\ub2a5\uc5d0 \uc791\uc6a9\ud558\ub294 \ub9cc\ud07c \ubc18\ub300\ub85c \uba74\uc5ed\uae30\ub2a5\uc744 \ub0ae\ucdb0\uc57c \ud558\ub294 \uba74\uc5ed\uc9c8\ud658\uc774 \ub3d9\ubc18\ub41c \uacbd\uc6b0, \ub610\ub294 \uac04\uc5fc\uacfc \uac19\uc740 \uac10\uc5fc\uc131 \uc9c8\ud658\uc744 \uac00\uc9c0\uace0 \uc788\ub294 \uacbd\uc6b0 \uba74\uc5ed\ud56d\uc554\uc81c\uc758 \uc0ac\uc6a9\uc740 \uc27d\uc9c0 \uc54a\ub2e4.<\/p>\n

\uc81c\uc57d\ud68c\uc0ac\ub294 \uc774\uc81c \ub9c9, \ud558\ub098 \ub458 \uadf8 \ubaa8\uc2b5\uc744 \ubcf4\uc774\uae30 \uc2dc\uc791\ud55c \uba74\uc5ed\ud56d\uc554\uc81c\ub4e4\uc774 \uadf8 \ud55c\uacc4\ub97c \uadf9\ubcf5\ud558\uace0 \ud56d\uc554 \uce58\ub8cc\uc758 \uc0c8\ub85c\uc6b4 \uc9c0\ud45c\ub97c \uc5f4 \uc218 \uc788\ub3c4\ub85d \ub728\uac70\uc6b4 \uad00\uc2ec\uacfc \uc5f0\uad6c\ub97c \uc3df\uace0 \uc788\ub2e4.<\/p>\n

\uad6d\ub0b4\uc5d0\uc11c\ub294 PD-1 \uacc4\uc5f4 \uba74\uc5ed\ud56d\uc554\uc81c\ub85c \ud0a4\ud2b8\ub8e8\ub2e4\uc640 \uc635\ub514\ubcf4\ub97c \ucd9c\uc2dc\ud558\uc600\ub2e4. \ud0a4\ud2b8\ub8e8\ub2e4\ub294 2016\ub144 5\uc6d4 \ud751\uc0c9\uc885, \ube44\uc18c\uc138\ud3ec\ud3d0\uc554 \uce58\ub8cc\uc81c\ub85c \uad6d\ub0b4 \uc2b9\uc778\uc744 \ubc1b\uc558\uace0 \uc635\ub514\ubcf4\ub294 \uc138\uacc4 \ucd5c\ucd08\ub85c PD-1 \uba74\uc5ed\ud56d\uc554\uc81c \uc2b9\uc778\uc744 \ubc1b\uc558\ub2e4.<\/p>\n

\uadf8\ubc16\uc5d0\ub3c4 \ub85c\uc288\uc758 \ud14c\uc13c\ud2b8\ub9ad\uc774 PD-1 \uacc4\uc5f4 \uba74\uc5ed\ud56d\uc554\uce58\ub8cc\uc81c\ub85c\uc11c \uc9c0\ub09c\ub2ec 5\uc6d4 \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d\uc5d0\uc11c \ucd5c\ucd08\ub85c \ubc29\uad11\uc554 \uce58\ub8cc\uc81c\ub85c \ubc1c\ub9e4 \ud5c8\uac00\ub97c \ubc1b\uc558\ub2e4.<\/p>\n

\uc778\uac04\uc758 \ud3c9\uade0 \uc218\uba85\uc774 \uacc4\uc18d \ub298\uc5b4\ub0a8\uc5d0 \ub530\ub77c \uc554 \ud658\uc790\uac00 \ub298\uace0 \uace0\ub839\ud654\ub418\uba74\uc11c \uc138\uacc4 \ud56d\uc554 \uce58\ub8cc\uc81c \uc2dc\uc7a5\uc774 \uc9c0\uc18d\uc801\uc73c\ub85c \uc131\uc7a5\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub41c\ub2e4.<\/p>\n

\uc138\uacc4 \uba74\uc5ed\ud56d\uc554\uc81c \uc2dc\uc7a5 \uaddc\ubaa8\ub294 2015\ub144 16\uc5b5 \ub2ec\ub7ec\uc5d0\uc11c \uc624\ub294 2020\ub144 350\uc5b5\ub2ec\ub7ec\ub85c \uc99d\uac00\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub418\uace0 2022\ub144\uc5d0\ub294 \ud56d\uc554\uc81c \ubd84\uc57c\uac00 1900\uc5b5 \ub2ec\ub7ec\uc758 \uc2dc\uc7a5 \uaddc\ubaa8\ub97c \uac00\uc9c0\uba70 \uc5f0\ud3c9\uade0 12.5%\uc758 \uc131\uc7a5\ub960\uc744 \ubcf4\uc77c \uac83\uc73c\ub85c \uc804\ub9dd\ub41c\ub2e4.<\/p>\n

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http:\/\/www.monews.co.kr\/news\/articleView.html?idxno=84804<\/p>\n

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\uba74\uc5ed\ud56d\uc554\uce58\ub8cc, \ubd84\uc790\uc0dd\ubb3c\ud559\uc73c\ub85c \ub0a0\uac1c<\/strong><\/h5>\n

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\uba74\uc5ed\uc2dc\uc2a4\ud15c\uc744 \uc870\uc808\ud574 \uc554\uc744 \uce58\ub8cc\ud558\ub294 \uc811\uadfc\ubc29\uc2dd\uc740 \uc0dd\uac01\ubcf4\ub2e4 \uc624\ub79c \uc804\ubd80\ud130 \uc2dc\ub3c4\ub3fc \uc654\ub2e4.<\/p>\n

1891\ub144 \ub274\uc695\uc758 \uc678\uacfc\uc758\uc0ac\uc600\ub358 \uc70c\ub9ac\uc5c4 \ucf5c\ub9ac(William B. Coley)\uac00 \uc218\uc220\uc774 \ubd88\uac00\ub2a5\ud55c \uc554\ud658\uc790\uc5d0\uac8c \uc6a9\ud608\uc131 \uc5f0\uc1c4\uc0c1\uad6c\uade0\uc744 \uc8fc\uc785\ud568\uc73c\ub85c\uc368 \uc545\uc131\uc885\uc591\uc758 \ucd95\uc18c\ubc18\uc751\uc744 \uc720\ub3c4\ud55c \uac83\uc774 \uc2dc\ucd08\ub77c\uace0 \uc5ec\uaca8\uc9c4\ub2e4. 1967\ub144\uc5d0\ub294 \uc624\uc2a4\ud2b8\ub808\uc77c\ub9ac\uc544\uc758 \uba74\uc5ed\ud559\uc790\uc778 \ud504\ub7ad\ud06c \ubc84\ub137(Frank M. Burnet) \ubc15\uc0ac\uac00 \uc815\uc0c1\uc801\uc778 \uba74\uc5ed\ubc18\uc751\uc73c\ub85c \uc554\uc138\ud3ec\uc5d0 \ub300\uc751\ud560 \uc218 \uc788\ub2e4\ub294 \uba74\uc5ed\uac10\uc2dc\uac00\uc124(immune surveillance theory)\uc744 \uc81c\uc2dc\ud558\uba70 \ud798\uc744 \uc2e4\uc5c8\ub2e4.<\/p>\n

1980\ub144\ub300\ubd80\ud130 \uc778\ud130\ud398\ub860\u00b7IL-2\uc5d0 \uad00\uc2ec<\/strong><\/p>\n\n\n\n\n
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\uba74\uc5ed\ud56d\uc554\uc694\ubc95\uc758 \uc784\uc0c1\uc5f0\uad6c\uac00 \ud65c\uae30\ub97c \ub760\uac8c \ub41c \uac83\uc740 1980\ub144\ub300 \uc911\ubc18 \uc774\ud6c4\ub2e4.<\/p>\n

\ubbf8\uad6d\ub9bd\uc554\uc5f0\uad6c\uc18c(NCI)\uc758 \uc2a4\ud2f0\ube10 \ub85c\uc820\ubc84\uadf8(Steven A. Rosenberg) \ubc15\uc0ac\ud300\uc740 \ud45c\uc900\uce58\ub8cc\uc5d0 \uc2e4\ud328\ud55c \uc804\uc774\uc554 \ud658\uc790 25\uba85\uc5d0\uac8c \uc7ac\uc870\ud569 \uc778\ud130\ub8e8\ud0a8-2(IL-2)\uc640 \ud658\uc790 \ubcf8\uc778\uc758 \uba74\uc5ed\uc138\ud3ec(Lymphokine-Activated Killer cell, LAK)\ub97c \ud22c\uc5ec\ud55c \uacb0\uacfc\ub97c NEJM 1985;313:1485-92\uc5d0 \uacf5\uac1c\ud588\ub2e4.<\/p>\n

\ub17c\ubb38\uc5d0 \ub530\ub974\uba74 \uba74\uc5ed\uce58\ub8cc\ub97c \ubc1b\uc558\ub358 25\uba85 \uc911 11\uba85\uc5d0\uc11c \uc885\uc591\uc758 \ud06c\uae30\uac00 50% \uc774\uc0c1 \uac10\uc18c\ud588\uace0, \uc804\uc774\uc131 \ud751\uc0c9\uc885\uc73c\ub85c \uc9c4\ub2e8\ubc1b\uc558\ub358 1\uba85\uc740 \uc554\uc138\ud3ec\uac00 \uc644\uc804\ud788 \uc0ac\ub77c\uc84c\uc73c\uba70(CR), \uadf8 \ud6a8\uacfc\uac00 10\uac1c\uc6d4\uc774 \ub118\ub294 \uae30\uac04 \ub3d9\uc548 \uc9c0\uc18d\ub410\ub2e4.<\/p>\n

\uc55e\uc120 \ub3d9\ubb3c\uc2e4\ud5d8\uc744 \ud1b5\ud574 \ub9c9\uc5f0\ud558\uac8c\ub098\ub9c8 \uc554\uc758 \uc9c4\ud589\uacfc\uc815\uc5d0 \uba74\uc5ed\uccb4\uacc4\uac00 \uad00\uc5ec\ud55c\ub2e4\ub294 \uac00\uc124\uc774 \uc54c\ub824\uc84c\uc9c0\ub9cc \ud658\uc790\uc758 \uba74\uc5ed\uc138\ud3ec\ub97c \ub2e4\uc2dc \uc8fc\uc785\ud568\uc73c\ub85c\uc368 \uba74\uc5ed\uae30\ub2a5\uc744 \uc870\uc808\ud558\uace0, \ud56d\uc554\ud6a8\uacfc\ub97c \uc720\ub3c4\ud560 \uc218 \uc788\ub2e4\ub294 \uac00\ub2a5\uc131\uc774 \uc784\uc0c1\ub2e8\uacc4\uc5d0\uc11c \uc81c\uc2dc\ub41c \uac83\uc740 \ucc98\uc74c \uc788\ub294 \uc77c.<\/p>\n

\uac00\ud1a8\ub9ad\uc758\ub300 \uac15\uc9c4\ud615 \uad50\uc218(\uc11c\uc6b8\uc131\ubaa8\ubcd1\uc6d0 \uc885\uc591\ub0b4\uacfc)\ub294 “\ub2f9\uc2dc\ub9cc \ud574\ub3c4 T\uc138\ud3ec, B\uc138\ud3ec\uc5d0 \ub300\ud55c \uac1c\ub150\uc774 \uc815\ub9bd\ub418\uc9c0 \uc54a\uc558\uc744 \ub54c\uc600\ub294\ub370, \uc2e0\uc7a5\uc554 \ud658\uc790\uc758 T\uc138\ud3ec\ub97c \ube7c\ub0b4 \ub9bc\ud3ec\uce74\uc778\uc774\ub77c\ub294 \ubb3c\uc9c8\ub85c \ud65c\uc131\ud654\uc2dc\ud0a8 \ub4a4 \ub2e4\uc2dc \uc8fc\uc785\ud588\ub354\ub2c8 \ud3d0\uc804\uc774 \ubcd1\uc18c\uac00 \uc904\uc5c8\ub2e4. \uc554\ud658\uc790\ub4e4\uc5d0\uac8c \uba74\uc5ed\uce58\ub8cc\uc758 \uac00\ub2a5\uc131\uc744 \ucc98\uc74c\uc73c\ub85c \uc81c\uc2dc\ud55c \uc758\ubbf8 \uc788\ub294 \uc5f0\uad6c”\ub77c\uace0 \ud3c9\uac00\ud588\ub2e4.<\/p>\n

\uad00\ub828 \uc5f0\uad6c\uac00 \uc9c0\uc18d\ub418\uba74\uc11c \uc2e0\uc7a5\uc554\ubcf4\ub2e4\ub3c4 \ud751\uc0c9\uc885\uc774 \uba74\uc5ed\uae30\uc804\uc774 \uc911\uc694\ud55c \uc554\uc73c\ub85c \uc8fc\ubaa9\uc744 \ubc1b\uae30 \uc2dc\uc791\ud55c\ub2e4.<\/p>\n

2000\ub144\ub300 \ub4e4\uc5b4 \uc601\uad6d \uae00\ub798\uc2a4\uace0\ub300\ud559 \ub85c\ub098 \ub9c8\ud0a4(Rona M. MacKie) \uad50\uc218\ub294 \uc2e0\uc7a5\uc774\uc2dd \ud6c4 \ud751\uc0c9\uc885\uc774 \ubc1c\uc0dd\ud55c \uc0ac\ub840\ub97c \ubcf4\uace0\ud588\ub2e4(NEJM 2003;348:567-568).<\/p>\n

\ud574\ub2f9 \ud658\uc790\uc5d0\uac8c \uc2e0\uc7a5\uc744 \uc774\uc2dd\ud574\uc900 \uae30\uc99d\uc790\ub294 16\ub144 \uc804 \ud751\uc0c9\uc885\uc744 \uc553\ub2e4 \uc81c\uac70\uc218\uc220\uc744 \ubc1b\uace0 \uc644\uce58\ub41c \ubcd1\ub825\uc774 \uc788\uc5c8\ub2e4. \ud765\ubbf8\ub86d\uac8c\ub3c4 \uae30\uc99d\uc790\uc5d0\uac8c\ub294 \ud751\uc0c9\uc885 \uc7ac\ubc1c \uc18c\uacac\uc774 \uc804\ud600 \uc5c6\uc5c8\uc9c0\ub9cc \uc218\ud61c\uc790\ub294 \uba74\uc5ed\uc5b5\uc81c\uc81c\ub97c \ubcf5\uc6a9\ud558\ub294 \uacfc\uc815\uc5d0\uc11c \ud751\uc0c9\uc885\uc774 \ubc1c\ud604\ub3fc \uacb0\uad6d \uc0ac\ub9dd\ud558\uace0 \ub9d0\uc558\ub2e4.<\/p>\n

\uba74\uc5ed\ubc18\uc751\uc73c\ub85c \uc554\uc744 \uc870\uc808\ud560 \uc218 \uc788\ub2e4\ub294 \ub370\uc11c \ud55c\uac78\uc74c \ub354 \ub098\uc544\uac00 \uba74\uc5ed\uccb4\uacc4\uac00 \uc81c\ub300\ub85c \uc791\ub3d9\ud558\uc9c0 \uc54a\uc744 \uacbd\uc6b0 \uc554\uc774 \uc7ac\ubc1c\ud560 \uc218 \uc788\ub2e4\ub294 \uc0ac\uc2e4\uae4c\uc9c0 \ud655\uc778\ud558\uac8c \ub41c \uc148\uc774\ub2e4.<\/p>\n

\uc774\ud6c4 \ud751\uc0c9\uc885 \ud658\uc790\ub4e4\uc744 \ub300\uc0c1\uc73c\ub85c \uc778\ud130\ud398\ub860, IL-2 \uac19\uc740 \ud65c\uc131\ubb3c\uc9c8\uc744 \uc8fc\uc785\ud558\uace0 \ub9bc\ud504\uad6c\ub97c \ud65c\uc131\ud654\uc2dc\ud0a4\ub294 \uc784\uc0c1\uc5f0\uad6c\uac00 10\uc5ec \ub144 \ub118\uac8c \uc2dc\ub3c4\ub3fc \uc654\ub2e4.<\/p>\n

\ubb38\uc81c\ub294 \uc77c\ub2e8 \uba74\uc5ed\uce58\ub8cc\uc758 \ud6a8\uacfc\uac00 \ub098\ud0c0\ub098\uba74 \ubc18\uc751\uc774 \uc624\ub798 \uc9c0\uc18d\ub418\uc9c0\ub9cc \uc5b4\ub5a4 \ud658\uc790\ub4e4\uc740 \ubc18\uc751\ud558\uc9c0 \uc54a\uace0, \uc5b4\ub5a4 \ud658\uc790\uc5d0\uc11c \uc798 \ubc18\uc751\ud558\ub294\uc9c0\uc870\ucc28 \uc54c \uc218 \uc5c6\ub2e4\ub294 \uac83.<\/p>\n

\uadfc\ub798\uc5d0\ub294 \ud751\uc0c9\uc885 \ud658\uc790\uc758 \ud608\uc561\uc73c\ub85c\ubd80\ud130 \uc218\uc9c0\uc0c1\uc138\ud3ec(dendritic cell)\ub97c \ubd84\ub9ac\ud574 \uccb4\uc678\uc5d0\uc11c \ud65c\uc131\ud654\uc2dc\ud0a8 \ub4a4 \ub2e4\uc2dc \ub123\uc5b4\uc8fc\ub294 \ubc29\uc2dd\uc758 \uc5f0\uad6c\ub3c4 \uc18c\uaddc\ubaa8\ub85c \uc9c4\ud589 \uc911\uc774\ub2e4.<\/p>\n

\uc774\ud544\ub9ac\ubb34\ub9d9\u00b7\ub2c8\ubcfc\ub8e8\ub9d9\u00a0‘\uc885\ud6a1\ubb34\uc9c4’…\ud751\uc0c9\uc885 \uc678 \ub2e4\ub978 \uc554\uc885\ub3c4 \uc5f0\uad6c \uc904\uc774\uc5b4<\/strong><\/p>\n

\uc784\uc0c1\uc5d0\uc11c \uba74\uc5ed\ud56d\uc554\uc81c \ub3c4\uc785\uc774 \ubcf8\uaca9\ud654 \ub41c \ub370\ub294 \uc774\ud544\ub9ac\ubb34\ub9d9(ipilimumab)\uc774\ub77c\ub294 \uc2e0\uc57d\uc758 \ub4f1\uc7a5\uc774 \uacb0\uc815\uc801 \uacc4\uae30\uac00 \ub410\ub2e4.<\/p>\n\n\n\n\n
<\/td>\n<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n\n\n\n\n
<\/td>\n\"\"<\/td>\n<\/td>\n<\/tr>\n
<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

BMS\uac00 \uac1c\ubc1c\ud55c \ud56dCTLA-4 \ub2e8\uc77c\ud074\ub860\ud56d\uccb4 \uc774\ud544\ub9ac\ubb34\ub9d9\uc740 \ubcc4\ub2e4\ub978 \uce58\ub8cc\uc218\ub2e8\uc774 \uc5c6\uc5c8\ub358 \uc804\uc774\uc131 \ud751\uc0c9\uc885 \ud658\uc790\uc758 \uc0dd\uc874\uc728\uc744 \uc720\uc758\ud558\uac8c \uc99d\uac00\uc2dc\ud0b4\uc73c\ub85c\uc368(NEJM 2010;363:711-23) \uc138\uacc4 \ucd5c\ucd08\ub85c \ubbf8\uad6d\uc2dd\ud488\uc758\uc57d\uad6d(FDA)\uc758 \uc2b9\uc778\uc744 \ubc1b\uc558\ub2e4.<\/p>\n

CTLA-4\ub294 T\uc138\ud3ec\uc640 \uc554\uc138\ud3ec \uc0ac\uc774\uc758 \ud6c4\uae30 \uba74\uc5ed\ubc18\uc751\uc5d0 \uad00\uc5ec, T\uc138\ud3ec \ud65c\uc131\uc744 \uc800\ud574\uc2dc\ud0a4\ub294 \ubb3c\uc9c8\uc774\ub2e4. \uc774\ub97c \ucc28\ub2e8\ud558\uba74 T\uc138\ud3ec\uc758 \ud65c\uc131 \ubc0f \uc99d\uc2dd\uc774 \uc99d\uac00\ub3fc \ud56d\uc554 \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0b8\ub2e4\ub294 \uac8c \uc774\ud544\ub9ac\ubb34\ub9d9\uc758 \uae30\ubcf8 \uc6d0\ub9ac\ub2e4.<\/p>\n

\uc218\uc220\uc774 \ubd88\uac00\ub2a5\ud558\uac70\ub098 \uc804\uc774\uc131\uc778 \ud751\uc0c9\uc885 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \uc9c4\ud589\ub410\ub358 3\uc0c1\uc784\uc0c1\uc5d0\uc11c \uc774\ud544\ub9ac\ubb34\ub9d9 3mg\/kg \ub2e8\ub3c5\uc694\ubc95\uc740 glycoprotein 100 \ub2e8\ub3c5\uc694\ubc95 \ub300\ube44 \uc0ac\ub9dd \uc704\ud5d8\uc744 34% \uac10\uc18c\uc2dc\ucf30\ub2e4(HR 0.66, 95% CI: 0.51-0.87; P=0.003). \uc77c\ubd80 \ud658\uc790\uc758 \uacbd\uc6b0 \uc885\uc591\ubc18\uc751\uae30\uac04(ORR)\uc774 44\uac1c\uc6d4\uc744 \ub118\uc5c8\ub2e4.<\/p>\n

\uc9c0\ub09c\ud574\uc5d0\ub294 \uc774\ud544\ub9ac\ubb34\ub9d9\uc774 \uc545\uc131 \ud751\uc0c9\uc885\uc758 \uc7ac\ubc1c\uc744 \ub9c9\ub294 \ub370\ub3c4 \ud6a8\uacfc\uc801\uc774\ub77c\ub294 \uc5f0\uad6c \uacb0\uacfc\uac00 \ubbf8\uad6d\uc784\uc0c1\uc885\uc591\ud559\ud68c \uc5f0\ub840\ud559\uc220\ub300\ud68c(ASCO 2014)\uc5d0\uc11c \ubc1c\ud45c\ub410\ub2e4.<\/p>\n

3\uae30 \ud751\uc0c9\uc885 \ud658\uc790 951\uba85\uc744 3\ub144\uac04 \ucd94\uc801\ud55c \uacb0\uacfc\uc5d0 \ub530\ub974\uba74 \uc774\ud544\ub9ac\ubb34\ub9d9\uad70\uc758 \ubb34\uc7ac\ubc1c\uc0dd\uc874\uc728(RFS)\uc774 46.5%\ub85c \uc704\uc57d\uad70(34.8%)\uc5d0 \ube44\ud574 11.7% \ub192\uc558\ub2e4.<\/p>\n

\ub610\ud55c \uc218\uc220\uc774 \ubd88\uac00\ub2a5\ud55c \uc804\uc774\uc131 \ud751\uc0c9\uc885 \ud658\uc790 1800\uc5ec \uba85\uc5d0 \ub300\ud55c \ud1b5\ud569\ubd84\uc11d(J Clin Oncol 2015;33:1889-94)\uc5d0\uc11c\ub294 \uc774\ud544\ub9ac\ubb34\ub9d9 \ud22c\uc5ec \ud6c4 \uc57d 3\ub144\uc9f8\ubd80\ud130 \uc548\uc815\uc801\uc778 \uc0dd\uc874\uace1\uc120\uc774 \uc720\uc9c0\ub428\uc744 \uc54c \uc218 \uc788\uc5c8\ub2e4. \uc774\ub54c \uc0dd\uc874\uc728\uc740 \uacfc\uac70 \uce58\ub8cc \uc5ec\ubd80\uc640 \uad00\uacc4 \uc5c6\uc774 20%\ub300\ub97c \uc720\uc9c0\ud588\uc73c\uba70, \uc77c\ubd80 \ud658\uc790\ub294 10\ub144\uae4c\uc9c0\ub3c4 \uc0dd\uc874\ud588\ub2e4.<\/p>\n

\ud604\uc7ac \uc774\ud544\ub9ac\ubb34\ub9d9\uc740 \ub2c8\ubcfc\ub8e8\ub9d9(nivolumab) \uac19\uc740 \ub2e4\ub978 \uba74\uc5ed\ud56d\uc554\uc81c\uc640\uc758 \ubcd1\uc6a9\uc694\ubc95(NEJM 2015;372:2006-2017)\uc744 \ube44\ub86f, \ud751\uc0c9\uc885\uc774 \uc544\ub2cc \ub2e4\ub978 \uc554\uc885\uc5d0 \ub300\ud574\uc11c\ub3c4 \uc784\uc0c1\uc5f0\uad6c\uac00 \ud65c\ubc1c\ud558\uac8c \uc9c4\ud589\ub418\uace0 \uc788\ub2e4.<\/p>\n

PD-1\u00b7PD-L1 \uc5b5\uc81c\uc81c \uacc4\uc5f4 \uba74\uc5ed\ud56d\uc554\uc81c \uc2b9\uc778 \uc787\ub530\ub77c<\/strong><\/p>\n

PD-1, PD-L1\uacfc \uac19\uc774 \uba74\uc5ed\uc791\uc6a9\uc5d0 \uad00\uc5ec\ud558\ub294 \ub610 \ub2e4\ub978 \ud0c0\uae43\ubd84\uc790\uc758 \ubc1c\uad74\uc740 \uc0c8\ub85c\uc6b4 \uba74\uc5ed\ud56d\uc554\uc81c\uc758 \uac1c\ubc1c\ub85c \uc774\uc5b4\uc84c\ub2e4.<\/p>\n

\uc138\uacc4 \ucd5c\ucd08\uc758 PD-1 \ud45c\uc801\uba74\uc5ed\ud56d\uc554\uc81c \ub2c8\ubcfc\ub8e8\ub9d9\uc740 PD-1\uacfc \uacb0\ud569\ud55c \ub4a4 PD-L1 \ubc0f PD-L2\uc640\uc758 \uc0c1\ud638\uc791\uc6a9\uc744 \ucc28\ub2e8\ud568\uc73c\ub85c\uc368 T\uc138\ud3ec\ub97c \uc7ac\ud65c\uc131\ud654\uc2dc\ud0a4\ub294 \uae30\uc804\uc73c\ub85c \uc6d0\ub9ac\ub294 CTLA-4 \uc5b5\uc81c\uc81c\uc640 \ub2e4\ub974\uc9c0 \uc54a\ub2e4.<\/p>\n

\uc9c0\ub09c\ud574 \ub9d0 \ubbf8\uad6d\uc5d0\uc11c \uc2b9\uc778\ub41c \ub2c8\ubcfc\ub8e8\ub9d9\uc740 \uc218\uc220\uc774 \ubd88\uac00\ub2a5\ud55c \uc804\uc774\uc131 \ud751\uc0c9\uc885 \uac00\uc6b4\ub370 \uc774\ud544\ub9ac\ubb34\ub9d9\uc5d0 \ubc18\uc751\ud558\uc9c0 \uc54a\ub294 \ud658\uc790\uc5d0\uac8c \ud22c\uc5ec\ud588\uc744 \ub54c \uae30\uc874 \ud56d\uc554\ud654\ud559\uc694\ubc95 \ub300\ube44 \ub6f0\uc5b4\ub09c \uc885\uc591\ubc18\uc751\ub960(Lancet Oncol 2015;16:375-84)\uc744 \uc120\ubcf4\uc600\ub2e4. BRAF \uc720\uc804\uc790\uc758 V600E \ub3cc\uc5f0\ubcc0\uc774\uac00 \ud655\uc778\ub41c \uacbd\uc6b0\ub77c\uba74 BRAF \uc5b5\uc81c\uc81c\uc640 \uc774\ud544\ub9ac\ubb34\ub9d9 \ubcd1\uc6a9 \ud6c4 \uc9c8\ubcd1\uc9c4\ud589\uc744 \ubcf4\uc778 \uc804\uc774\uc131 \ud751\uc0c9\uc885 \ud658\uc790\uc5d0\uac8c\ub3c4 \ud22c\uc5ec\ud560 \uc218 \uc788\ub2e4.<\/p>\n

\ucd5c\uadfc\uc5d0\ub294 \ud751\uc0c9\uc885\uc740 \ubb3c\ub860 \ud3d0\uc554\uc5d0\uc11c\ub3c4 \uc885\ud6a1\ubb34\uc9c4 \uc801\uc751\uc99d\uc744 \ub113\ud600\uac00\ub294 \ubaa8\uc2b5\uc774\ub2e4.<\/p>\n

\uc9c0\ub09c 3\uc6d4\uc5d0\ub294 \ubc31\uae08\uae30\ubc18 \ud56d\uc554\ud654\ud559\uc694\ubc95\uc744 \ubc1b\uc558\ub358 \uc9c4\ud589\uc131 \ud3b8\ud3c9\uc0c1\ud53c \ube44\uc18c\uc138\ud3ec\ud3d0\uc554(NSCLC) \ud658\uc790\uc5d0\uc11c \ub3c4\uc138\ud0c1\uc140 \ub300\ube44 \uc804\uccb4 \uc0dd\uc874\uae30\uac04(OS)\uc744 3.2\uac1c\uc6d4 \uc5f0\uc7a5\uc2dc\ucf30\ub2e4\ub294 \uc784\uc0c1 \uadfc\uac70\uc5d0 \ub530\ub77c FDA \uc6b0\uc120\uc2ec\uc0ac \ub300\uc0c1\uc73c\ub85c \uc120\uc815, \ubcf8\ub798 \uc608\uc815\uc77c\ubcf4\ub2e4 3\uac1c\uc6d4\uac00\ub7c9 \uc55e\ub2f9\uaca8 \ud655\ub300\uc2b9\uc778 \ub410\ub2e4.<\/p>\n

\ub610\ud55c \ubbf8\uad6d\uc784\uc0c1\uc885\uc591\ud559\ud68c(ASCO 2015) \uae30\uac04 \uc911\uc5d0\ub294 \ud0c0\uc774\ub85c\uc2e0\ud0a4\ub098\uc81c\uc5b5\uc81c\uc81c(TKI)\uc640 \ubc31\uae08\ud654\ud559\uc694\ubc95 \uc774\ud6c4 \uc7ac\ubc1c\ud55c \ube44\ud3b8\ud3c9\uc0c1\ud53c \ube44\uc18c\uc138\ud3ec\ud3d0\uc554 \ud658\uc790\uc758 \uc0ac\ub9dd\ub960\uc744 \ub3c4\uc138\ud0c1\uc140\uad70(OS, 12.2\uac1c\uc6d4 vs. 9.4\uac1c\uc6d4) \ub300\ube44 27% \uac10\uc18c\uc2dc\ucf30\ub2e4\ub294 Checkmate 057 \uc5f0\uad6c\ub85c \uc8fc\ubaa9\uc744 \ubc1b\uc558\ub2e4.<\/p>\n

\ucd08\uae30 \uc784\uc0c1\uc774\uc5c8\uc9c0\ub9cc \uc9c4\ud589\uc131 \uac04\uc138\ud3ec\uc554(HCC) \ud658\uc790\uc5d0\uac8c \ub2c8\ubcfc\ub8e8\ub9d9\uc744 \ud22c\uc5ec\ud588\uc744 \ub54c 6\uac1c\uc6d4 \uc9f8 \uc804\uccb4\uc0dd\uc874\uc728(OS)\uc774 72%, 12\uac1c\uc6d4 \uc9f8 62%\ub85c \uc18c\ub77c\ud398\ub2d9\uc758 \ud3c9\uade0 \uc0dd\uc874\uc728(\uc57d 30%)\uc744 \ud6cc\uca4d \ub6f0\uc5b4\ub118\uc5c8\ub2e4\ub294 \ud765\ubbf8\ub85c\uc6b4 \ub370\uc774\ud130\ub3c4 \uc788\ub2e4(ASCO 2015 #Abstract LBA101).<\/p>\n

\ub2f9\uc2dc \uc804\uccb4 41\uba85 \uc911 2\uba85(5%)\uc774 \uc644\uc804\ubc18\uc751(CR)\uc744, 7\uba85(18%)\uc774 \ubd80\ubd84\ubc18\uc751(PR)\uc744 \ubcf4\uc600\uace0 \uac01\uac01\uc5d0\uc11c \ubc18\uc751\uc9c0\uc18d\uae30\uac04\uc740 14~17\uac1c\uc6d4, 1~8\uac1c\uc6d4\uc774\uc5c8\ub2e4. \uc5f0\uad6c \ucc38\uc5ec\uad70 \uc911 \uc808\ubc18\uac00\ub7c9(20\uba85)\uc774 \uc548\uc815\ubcd1\ubcc0(SD)\uc744 \uc720\uc9c0\ud588\uc73c\uba70, \uc774\ub7ec\ud55c \uc0c1\ud0dc\uac00 \ucd5c\ub300 17\uac1c\uc6d4\uae4c\uc9c0 \uc9c0\uc18d\ub410\ub2e4\ub294 \ubcf4\uace0\ub2e4.<\/p>\n

‘\uba74\uc5ed\ud45c\uc801’ \uac1c\ub150 \ub3c4\uc785\u2026\ubd84\uc790 \uc218\uc900\uc5d0\uc11c \uba74\uc5ed\uc870\uc808<\/strong><\/p>\n

 <\/p>\n

\uac00\ud1a8\ub9ad\uc758\ub300 \uac15\uc9c4\ud615 \uad50\uc218\ub294 “\uba74\uc5ed\ud56d\uc554\uc81c\uac00 \ub450\uacbd\ubd80\uc554, \ud3d0\uc554, \ud751\uc0c9\uc885, \uc2e0\uc7a5\uc554 \ub4f1 \uae30\uc874 \ud56d\uc554\uc81c\uc5d0 \ubc18\uc751\ud558\uc9c0 \uc54a\uc558\ub358 \ub2e4\uc591\ud55c \uc554\uc885\uc5d0 \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0b8\ub2e4”\uba74\uc11c “\uc778\ud130\ud398\ub860, IL-2\ub97c \uc774\uc6a9\ud55c \uba74\uc5ed\uce58\ub8cc\uc640 \ub9c8\ucc2c\uac00\uc9c0\ub85c \uc77c\ub2e8 \ubc18\uc751\uc774 \uc788\ub294 \ud658\uc790\ub294 \uc9c0\uc18d\uae30\uac04\uc774 \uc0c1\ub2f9\ud788 \uae38\ub2e4”\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\ub2e4\ub9cc \uba74\uc5ed\uccb4\uacc4 \ub0b4\uc758 \ud45c\uc801\uc744 \uc54c\uace0 \uc788\ub2e4\ub294 \uac8c \ubd84\uba85\ud55c \ucc28\uc774.<\/p>\n

\uacfc\uac70\uc758 \uba74\uc5ed\uce58\ub8cc\uac00 \ubd88\ud2b9\uc815\ud55c \uba74\uc5ed\uc138\ud3ec\ub97c \uc790\uadf9\uc2dc\ud0a4\ub294 \ubc29\uc2dd\uc5d0 \uba38\ubb3c\ub800\ub2e4\uba74 \uc554\uacfc \uba74\uc5ed\uacc4 \uc0ac\uc774\uc758 \uc870\uc808\uae30\uc804\uc774 \ubc1d\ud600\uc9c4 \uc9c0\uae08\uc740 \uc138\ud3ec \ub0b4 \ubd84\uc790 \uc218\uc900\uc5d0\uc11c \ud2b9\uc815 \ubb3c\uc9c8\uc744 \ucc28\ub2e8\ud558\uace0 \uba74\uc5ed\uc138\ud3ec\uc758 \ud65c\uc131\uc744 \uc720\ub3c4\ud558\ub294 \uba74\uc5ed\ud45c\uc801\ud56d\uc554\uc81c\ub85c \uc9c4\uc77c\ubcf4 \ud55c \uc148\uc774\ub2e4.<\/p>\n

\ucc28\uc138\ub300\uc5fc\uae30\uc11c\uc5f4\ubd84\uc11d(NGS) \uae30\uc220\uc758 \ubc1c\ub2ec\ub85c \uc554\uc885\ubcc4 \uc720\uc804\uc790 \ubcc0\uc774\uc758 \ube48\ub3c4(frequency)\ub3c4 \ud655\uc778\ud560 \uc218 \uc788\uac8c \ub410\ub2e4. \uac15 \uad50\uc218\ub294 “\ud751\uc0c9\uc885\uc774\ub098 \ud3b8\ud3c9\uc0c1\ud53c \ube44\uc18c\uc138\ud3ec\ud3d0\uc554, \ub450\uacbd\ubd80\uc554 \uac19\uc774 \ubcc0\uc774 \ube48\ub3c4 \ub610\ub294 \uc720\uc804\uc790 \ubcc0\uc774 \ubd80\ub2f4(mutation burden)\uc774 \ub192\uc740 \uc554\uc885\uc77c\uc218\ub85d \uba74\uc5ed\ud56d\uc554\uc81c\uc5d0 \uc798 \ub4e3\ub294\ub2e4”\uace0 \uc18c\uac1c\ud588\ub2e4.<\/p>\n

\uc720\uc804\uc790 \ubcc0\uc774\uac00 \ub9ce\uc73c\uba74 \uc138\ud3ec\uac00 \uc81c \uae30\ub2a5\uc744 \ud558\uc9c0 \ubabb\ud574 \uc138\ud3ec\uc9c8\uc774\ub098 \uc138\ud3ec\ud45c\uba74 \ub0b4\uc5d0 \ube44\uc815\uc0c1\uc801(abberant) \ub2e8\ubc31\uc9c8\uc744 \ub9ce\uc774 \ub9cc\ub4e4\uc5b4\ub0b4\ub294\ub370, \uc774\ub4e4\uc774 \ud56d\uc6d0\uc131(antigenecity)\uc744 \uac00\uc9c0\ubbc0\ub85c T\uc138\ud3ec, \uc218\uc9c0\uc0c1\uc138\ud3ec \ub4f1 \uba74\uc5ed\ubc18\uc751\uc758 \uad00\uc5ec\uac00 \ud65c\ubc1c\ud574\uc9c4\ub2e4\ub294 \uac83.<\/p>\n

\uc774\ub54c \uc554\uc138\ud3ec\uac00 \uba74\uc5ed\ud68c\ud53c \uae30\uc804\uc73c\ub85c\uc11c T\uc138\ud3ec\ub97c \ucc28\ub2e8\ud558\uae30 \uc704\ud574 \uc138\ud3ec \ud45c\uba74\uc5d0 \ub9cc\ub4e4\uc5b4\ub0b4\ub294 CTLA-4, PD-1 \ub4f1\uc758 \ubb3c\uc9c8\ub4e4(inhibitory immune checkpoint molecule)\uc774 \uc624\ub298\ub0a0 \uba74\uc5ed\ud56d\uc554\uc81c\uc758 \ud0c0\uae43\uc774\ub2e4.<\/p>\n

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http:\/\/nov.ncc.re.kr\/%EA%B8%B0%EC%88%A0%EB%8F%99%ED%96%A5-%EB%A9%B4%EC%97%AD%EC%B2%B4%EB%A3%8C%EC%A0%9C-%EA%B0%9C%EB%B0%9C%EB%8F%99%ED%96%A5\/<\/p>\n

<\/h5>\n
\uba74\uc5ed\uce58\ub8cc\uc81c \uac1c\ubc1c\ub3d9\ud5a5 –<\/span><\/strong>\u00a02017\ub144 1\uc6d4 \ud604\uc7ac<\/strong><\/h5>\n
\n

 <\/p>\n

\u2022\u00a0 \ucd5c\uadfc\uc758 \uc554 \uce58\ub8cc\ub294 \uae30\uc874\uc5d0 \uac01\uad11\uc744 \ubc1b\ub358 \ud45c\uc801\ud56d\uc554\uce58\ub8cc\uc5d0\uc11c \uba74\uc5ed\uce58\ub8cc\uc81c\ub85c \u2018\ud328\ub7ec\ub2e4\uc784 \uc2dc\ud504\ud2b8\u2019\uac00 \uc774\ub8e8\uc5b4\uc9c0\uace0 \uc788\uc73c\uba70, \ucd5c\uadfc 3~4\ub144 \uc0ac\uc774 \uba74\uc5ed\uc694\ubc95\uc758 \uc554 \uce58\ub8cc\ub294 \ud55c \ub2e8\uacc4 \ub354 \uc9c4\ubcf4\ud558\uba70 \ud6a8\uacfc\ub97c \uc785\uc99d\ud558\ub294 \ubb3c\uc9c8\ub4e4\uc774 \uac1c\ubc1c\ub428<\/p>\n

 <\/p>\n

\u2013 2010\ub144\ub3c4\ubd80\ud130 FDA\uc758 \uc2b9\uc778\uc744 \ubc1b\uc740 \uba74\uc5ed\uce58\ub8cc\uc81c\uac00 \ud604\uc7ac\uae4c\uc9c0 7\uac74\uc774 \uc2b9\uc778\ub418\ub294 \ub4f1 \uba74\uc5ed\ud56d\uc554\uc694\ubc95\uc758 \uc801\uc6a9\uc774 \ubcf8\uaca9\ud654\ub418\uace0 \uc788\uc74c<\/p>\n

\"%ed%91%9c1\"<\/p>\n

\u2022 \uc554 \uba74\uc5ed\uce58\ub8cc\uc81c\ub294 \uba74\uc5ed\uc2dc\uc2a4\ud15c\uc744 \uc790\uadf9\ud558\uc5ec \uc554\uc744 \uce58\ub8cc\ud558\ub294 \ubd84\uc57c\uc774\uba70, \uc778\uccb4\uc758 \uba74\uc5ed\uc2dc\uc2a4\ud15c \uc774\uc6a9 \ubc29\ubc95\uc5d0 \ub530\ub77c \ub2a5\ub3d9\uc801\/\uc218\ub3d9\uc801 \uba74\uc5ed\uce58\ub8cc\ub85c \uad6c\ubd84 \ud560 \uc218 \uc788\uc74c<\/p>\n

 <\/p>\n

(<\/b>\uc218\ub3d9\uc801 \uba74\uc5ed\uce58\ub8cc<\/b>)<\/b>\u00a0\uccb4\uc678\uc5d0\uc11c \ub2e4\ub7c9\uc73c\ub85c \ub9cc\ub4e4\uc5b4\uc9c4 \uba74\uc5ed\ubc18\uc751 \uc131\ubd84(\uba74\uc5ed\uc138\ud3ec, \ud56d\uccb4, \uc0ac\uc774\ud1a0\uce74\uc778 \ub4f1)\uc744 \uc554\ud658\uc790\uc5d0\uac8c \uc8fc\uc785\ud558\uc5ec \uc554\uc138\ud3ec\ub97c \uacf5\uaca9\ud558\ub294 \uce58\ub8cc\ubc29\ubc95<\/p>\n

 <\/p>\n

(<\/b>\ub2a5\ub3d9\uc801 \uba74\uc5ed\uce58\ub8cc<\/b>)\u00a0<\/b>\uac1c\uc778\uc758 \ud56d\uccb4\uc640 \uba74\uc5ed\uc138\ud3ec\ub4e4\uc744 \ub2a5\ub3d9\uc801\uc73c\ub85c \ud65c\uc131\ud654 \ub610\ub294 \uc0dd\uc0b0\uc2dc\ud0a4\uac8c\ub054 \ud558\uc5ec \uc554\uc138\ud3ec\ub97c \uacf5\uaca9\ud558\ub294 \uce58\ub8cc\ubc29\ubc95<\/p>\n

\"%ed%91%9c2\"<\/p>\n

\u2022\u00a0 IMS Institute\uc5d0 \ub530\ub974\uba74 \uc804\uc138\uacc4\uc801\uc73c\ub85c \uc554 \uba74\uc5ed\uce58\ub8cc\uc81c\uc5d0 \ub300\ud574 \ud65c\ubc1c\ud788 \uc5f0\uad6c \uc911\uc774\uba70, PD-1 inhibitor, CDK inhibitor, Anti-CTLA-4 antibody, CAR T-cell therapy, ALK inhibitor \ub4f1 \ub2e4\uc591\ud55c \uc720\ud615\uc758 \uc554\uba74\uc5ed\uce58\ub8cc\uc81c \uac1c\ubc1c\uc744 \uc704\ud55c \uc5f0\uad6c\uac00 \uc8fc\ub85c \uc9c4\ud589 \uc911<\/p>\n

 <\/p>\n

\u2013 \uc554 \uba74\uc5ed\uce58\ub8cc\uc81c\ub85c\uc11c PD-1, PD-L1\uc774 \uac00\uc7a5 \ud65c\ubc1c\ud558\uac8c \uc5f0\uad6c\ub418\uace0 \uc788\uc73c\uba70, PD-1\uc740 \uae30 \ud5c8\uac00\ubc1b\uc740 \uc57d\ubb3c\ub85c \uc801\uc751\uc99d \ud655\ub300\ub97c \uc704\ud55c \ucd94\uac00 \uc784\uc0c1\uc5f0\uad6c \ubc0f \uc2e0\uaddc \uc57d\ubb3c \uac1c\ubc1c \uc5f0\uad6c\uac00 \uc774\ub8e8\uc5b4\uc9c0\uace0 \uc788\uc73c\uba70, PD-L1\uc740 \uc544\uc9c1\uae4c\uc9c0 FDA \uc2b9\uc778\uc744 \ubc1b\uc740 \uc57d\ubb3c\uc740 \uc5c6\uc73c\ub098 \ucd5c\uadfc PD-1\uacfc \ud568\uaed8 \uc9d1\uc911\uc801\uc778 \uc5f0\uad6c\uac00 \uc774\ub8e8\uc5b4\uc9c0\uace0 \uc788\uc74c<\/p>\n

\u2013 CAR-T \uc138\ud3ec\uce58\ub8cc\uc81c\ub294 \ucc28\uc138\ub300 \uac1c\uc778\ub9de\ucda4 \uc758\ub8cc \uc2e0\uc57d\uc73c\ub85c \ubd80\uc0c1\ud558\uace0 \uc788\uace0 \ud608\uc561\uc554 \uce58\ub8cc\uc5d0 \ucc98\uc74c \uc801\uc6a9\ub420 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uc804\ub9dd\ub418\uba70, 2020\ub144\ub300\uc5d0\ub294 \uc0c1\uc6a9\ud654 \ub420 \uac83\uc73c\ub85c \uc804\ub9dd<\/p>\n

\u2013 \uba74\uc5ed\uce58\ub8cc\uc81c \uac1c\ubc1c \uc2dc CTLA4\uc640 PD-1, PD-L1 \uc774\uc678\uc5d0\ub3c4 OX40, LAG-3, STING \ub4f1\uc758 \uc5f0\uad6c\uac00 \ud65c\ubc1c\ud788 \uc774\ub8e8\uc5b4\uc9c8 \uc608\uc815\uc774\uba70, \uadf8 \uc678\uc5d0\ub3c4 NK cell\uacfc \ub300\uc2dd\uc138\ud3ec(macrophage)\ub97c \ud0c0\uac9f\uc73c\ub85c \ub514\uc790\uc778\ub41c agents\uac00 \uac1c\ubc1c\ub420 \uac83\uc73c\ub85c \uc804\ub9dd\ub428<\/p>\n

 <\/p>\n

\"%ed%91%9c3%ea%b7%b8%eb%a6%bc1\"<\/p>\n

\u2022\u00a0 \ucd5c\uadfc \uba74\uc5ed\uce58\ub8cc\uc81c \uac1c\ubc1c\uc5d0\uc11c\uc758 \uac00\uc7a5 \uc911\uc2ec\uc801\uc778 \ud0a4\uc6cc\ub4dc\ub294 T\uc138\ud3ec\uc774\uba70, T\uc138\ud3ec \ud65c\uc131\ud654\ub97c \ud1b5\ud55c \ud56d\uc554\uc81c \uac1c\ubc1c\uc740 \ud06c\uac8c T\uc138\ud3ec\ub97c \uc9c1\uc811 \uc790\uadf9\ud558\ub294 \ubc29\uc2dd\uacfc \ub2e4\ub978 \uba74\uc5ed\uc138\ud3ec\ub4e4\uc744 \uc790\uadf9\ud558\ub294 \uac04\uc811\uc801\uc778 \ubc29\uc2dd\uc73c\ub85c \ubd84\ub958\ud560 \uc218 \uc788\uc74c<\/p>\n

 <\/p>\n

\u2013 T\uc138\ud3ec\ub97c \uc9c1\uc811 \uc790\uadf9\ud558\ub294 \ubc29\uc2dd\uc740 \ub2e4\uad6d\uc801\uc81c\uc57d\uc0ac\ub4e4\uc758 \uac1c\ubc1c\uc774 \uc9d1\uc911\ub418\uace0 \uc788\ub294 PD-1, CTLA-4, LAG-3, TIM-3 \ub4f1\uc758 \uba74\uc5ed\uccb4\ud06c\ud3ec\uc778\ud2b8\ub97c \uc5b5\uc81c(Immune checkpoint modulator)\ud558\ub294 \ubc29\uc2dd\uacfc \ub610\ub294 OX40, CD137, CD27, CD40 \ub4f1 \ubcf4\uc870\ud65c\uc131\uc778\uc790\ub97c \uc790\uadf9\ud558\ub294 \ubc29\uc2dd\uc784<\/p>\n

\u2013 T\uc138\ud3ec\ub97c \uac04\uc811 \uc790\uadf9\ud558\ub294 \ubc29\uc2dd\uc740 Treg, MDSC, TAM, IDO \ub4f1 \uccb4\ub0b4 \uba74\uc5ed\uae30\ub2a5 \uc5b5\uc81c\ub97c \uc720\ubc1c\ud558\ub294 \uc778\uc790\ub4e4\uc744 \uc5b5\uc81c\ud558\uac70\ub098 \ud654\ud559\uc694\ubc95 \ubc0f \ubc29\uc0ac\uc120\uc694\ubc95\uc744 \ud1b5\ud574 \uba74\uc5ed\ubc18\uc751\uc744 \uc790\uadf9\ud558\ub294 \ubc29\uc2dd\uc784<\/p>\n

 <\/p>\n

\"%ea%b7%b8%eb%a6%bc2\"<\/p>\n

\u2022 \uba74\uc5ed\uce58\ub8cc\uc81c \uc911 \uac00\uc7a5 \ud65c\ubc1c\ud55c \uc5f0\uad6c\uac00 \uc774\ub8e8\uc5b4\uc9c0\uace0 \uc788\ub294 \uba74\uc5ed\uccb4\ud06c\ud3ec\uc778\ud2b8\uc800\ud574\uc81c\uc778 Anti-PD-1\/PD-L1\uc758 \uacbd\uc6b0, 2014\ub144 \uae30\uc900 \ud6c4\uae30 \uac1c\ubc1c\ub2e8\uacc4\uc758 \ube14\ub85d\ubc84\uc2a4\ud130 \ud30c\uc774\ud504\ub77c\uc778 \ud604\ud669\uc5d0\uc11c \uc0c1\uc704 1~3\uc704\ub97c \ucc28\uc9c0\ud558\uc5ec \uba74\uc5ed\ud56d\uc554\uc81c \uc911\uc5d0\uc11c\ub3c4 \uac00\uc7a5 \ube60\ub974\uac8c \uc0c1\uc5c5\uc801 \uc131\uacfc\ub97c \uac00\uc838\uc62c \uac83\uc73c\ub85c \uc608\uc0c1\ub428<\/p>\n

 <\/p>\n

\uc774 \uc911 PD-1 \uc5b5\uc81c\uc81c\uc778 Nivolumab\uc740 2015\ub144 \ud3d0\uc554, \uc2e0\uc7a5\uc554\uc5d0 \ub300\ud574 FDA \uc2b9\uc778\uc744 \ud68d\ub4dd<\/p>\n

\"%ed%91%9c4\"<\/p>\n

\u2022 \uba74\uc5ed\ud56d\uc554\uc81c \ub2e8\ub3c5\uc694\ubc95 \uac1c\ubc1c \ubfd0 \uc544\ub2c8\ub77c \ubcd1\uc6a9\uc694\ubc95\ub3c4 \ud654\ub450\uac00 \ub418\uace0 \uc788\uc73c\uba70, \ub2e4\uc591\ud55c \uba74\uc5ed\uc870\uc808 \uacbd\ub85c \ub610\ub294 \uba74\uc5ed\uc870\uc808\uc790\ub4e4\uc744 \uc790\uadf9 \ubc0f \uc5b5\uc81c\ud558\ub294 \ubc29\ud5a5\uc73c\ub85c \uba74\uc5ed\ud56d\uc554\uc81c \uac1c\ubc1c\uc774 \uc774\ub8e8\uc5b4\uc9c0\uba74\uc11c \ubcd1\uc6a9\uce58\ub8cc\uac00 \uba74\uc5ed\ud56d\uc554\uc694\ubc95 \uac1c\ubc1c\uc758 \uae30\ubcf8 \uc804\ub7b5\uc774 \ub418\uace0 \uc788\uc74c\"%ea%b7%b8%eb%a6%bc3\"<\/p>\n

\u2013 \uba74\uc5ed\uce58\ub8cc\uc81c\uc640\uc758 \ubcd1\uc6a9\uce58\ub8cc\ub97c \uc2e4\uc2dc\ud560 \uacbd\uc6b0 \uc554 \ud658\uc790\uc758 \uc804\uccb4 \uc0dd\uc874\uae30\uad00\uc744 \uc99d\ub300\uc2dc\ud0a4\uace0 \uce58\ub8cc\uc801 \ubc18\uc751\uc758 \uc9c0\uc18d\uc131\uc744 \uc720\uc9c0\ud560 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uc804\ub9dd<\/p>\n

\u2013 \uba74\uc5ed\uce58\ub8cc\ubc95\uacfc \ud0c0 \uce58\ub8cc\ubc95\uc758 \ubcd1\uc6a9\ubfd0 \uc544\ub2c8\ub77c, \uba74\uc5ed\uce58\ub8cc \ub0b4\uc5d0\uc11c\ub3c4 \ub2e8\uc77c\ud074\ub860\ud56d\uccb4, \uc0ac\uc774\ud1a0\uce74\uc778, \ubc31\uc2e0 \ub4f1\uc5d0\uc11c \uae30\ub300\ud560 \uc218 \uc788\ub294 \uae30\ub300\ud6a8\uacfc\uac00 \uac01\uae30 \uc0c1\uc774\ud55c \ubc14 \ub2e4\uc591\ud55c \uc811\uadfc\uc744 \ub3d9\uc2dc\uc5d0 \ud65c\uc6a9\ud568\uc73c\ub85c\uc368 \ud56d\uc554 \ud6a8\uacfc\ub97c \uadf9\ub300\ud654\ud560 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uc804\ub9dd\ub428<\/p>\n

\u2013 \ud56d\uc554 \uba74\uc5ed\uce58\ub8cc\uc758 \ubcd1\uc6a9\uc694\ubc95\uc5d0\uc11c\ub3c4 \uac00\uc7a5 \uc911\uc2ec\uc801\uc778 \ud0a4\uc6cc\ub4dc\ub294 T\uc138\ud3ec\uc774\uba70, \ubcd1\uc6a9\uc694\ubc95\uc758 \ubaa9\ud45c\ub294 T\uc138\ud3ec\ub97c \uc554\uc138\ud3ec\uc5d0 \uadfc\uc811\ud558\uac8c \uc720\ub3c4\ud558\uae30 \uc704\ud55c \uc804\ub7b5(TILs)\uacfc \uc885\uc591\uc138\ud3ec\uc5d0 \uadfc\uc811\ud588\uc5b4\ub3c4 \ud0c8\uc9c4\ud55c T\uc138\ud3ec\ub97c \ud65c\uc131\ud654\uc2dc\ud0a4\ub294 \uc804\ub7b5 \ub4f1\uc744 \ud65c\uc6a9\ud558\uc5ec \ud604\uc7ac\uae4c\uc9c0 \ubc1d\ud600\uc9c4 \uce58\ub8cc\ud6a8\uacfc\ub97c \ub354\uc6b1 \ud5a5\uc0c1\uc2dc\ud0a4\uace0\uc790 \ud568<\/p>\n

-\ud2b9\ud788 T\uc138\ud3ec \ud65c\uc131\ud654 \uc804\ub7b5\uc758 \ud558\ub098\ub85c \uba74\uc5ed\uccb4\ud06c\ud3ec\uc778\ud2b8 \uc5b5\uc81c\uc81c\ub97c \uc911\uc2ec\uc73c\ub85c \ud55c \ubcd1\uc6a9\uce58\ub8cc\uc694\ubc95\uc758 \uc784\uc0c1\uc2dc\ud5d8\uc774 \uc804\uc138\uacc4\uc801\uc73c\ub85c \ub2e4\uc591\ud558\uac8c \uc9c4\ud589\ub418\uace0 \uc788\uc74c<\/p>\n

\"%ed%91%9c5\"<\/p>\n<\/div>\n

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 <\/p>\n<\/div>\n<\/div>\n<\/div>\n

PD-1\u00b7PD-L1 \uacc4\uc5f4, \uc801\uc751\uc99d \ucd94\uac00\u00b7\ubcd1\uc6a9\uc5f0\uad6c \ud65c\ubc1c
\n\ub04a\uc784\uc5c6\ub294 \uc9c4\ud654\u2026\uac70\uc758 \ubaa8\ub4e0 \uace0\ud615\uc554\uc5d0 \ub3c4\uc804\uc7a5<\/strong><\/p>\n

\uad6d\ub0b4\uc678\uc5d0\uc11c \ud5c8\uac00\ub41c \uba74\uc5ed\ud56d\uc554\uc81c\ub294 2~3\uac1c\uc5d0 \ubd88\uacfc\ud558\uc9c0\ub9cc \uac1c\ubc1c\ub418\ub294 \uc57d\ubb3c\uc774 \ub9ce\uc544 \ud5a5\ud6c4 2~3\ub144 \uc548\uc774\uba74 \uc0ac\uc6a9\ud560 \uc218 \uc788\ub294 \uc57d\ubb3c\uc774 \ub354 \ub298\uc5b4\ub0a0 \uc804\ub9dd\uc774\ub2e4. \uc885\ub958\ub294 \uaca8\ub0e5\ud558\ub294 \uc138\ud3ec\uc5d0 \ub530\ub77c \uba74\uc5ed\uc138\ud3ec\uc5d0 \uc791\uc6a9\ud558\ub294 PD-1\uacfc \uc885\uc591\uc138\ud3ec\uc5d0 \uc791\uc6a9\ud558\ub294 PD-L1 \uacc4\uc5f4\ub85c \uad6c\ubd84\ub41c\ub2e4.<\/p>\n

PD-1 \uacc4\uc5f4<\/p>\n

PD-1\uc744 \uaca8\ub0e5\ud558\ub294 \uc57d\ubb3c\ub85c\ub294 \ub2c8\ubcfc\ub8e8\ub9d9, \ud3a8\ube0c\ub864\ub9ac\uc8fc\ub9d9, AMP-224, AMP-554, \ud53c\ub51c\ub9ac\uc8fc\ub9d9(pidilizumab, CT-011) \ub4f1\uc774 \uc788\ub2e4. \ud2b9\ud788 \ub2c8\ubcfc\ub8e8\ub9d9, \ud3a8\ube0c\ub864\ub9ac\uc8fc\ub9d9\uc740 \uc774\ubbf8 \uad6d\ub0b4\uc5d0\uc11c\ub3c4 \ud5c8\uac00\ub97c \ubc1b\uc740 \uc57d\ubb3c\ub85c \uae30\ubcf8 \uc801\uc751\uc99d \uc678 \uc801\uc751\uc99d \ud655\ub300\ub97c \uc704\ud55c \ucd94\uac00 \uc784\uc0c1\uc774 \uc9c4\ud589 \uc911\uc774\ub2e4.<\/p>\n

\u25b6 \ub2c8\ubcfc\ub8e8\ub9d9<\/strong>
\n\ub2c8\ubcfc\ub8e8\ub9d9(nivolumab)\uc740 \uc77c\ubcf8 \uc624\ub178\uc81c\uc57d\uc774 \uac1c\ubc1c\ud55c \uc81c\ud488\uc73c\ub85c, \uc9c0\ub09c 3\uc6d4 \uc635\ub514\ubcf4\ub77c\ub294 \uc81c\ud488\uba85\uc73c\ub85c \uc2dd\ud488\uc758\uc57d\ud488\uc548\uc804\ucc98\uc758 \uc2b9\uc778\uc744 \ubc1b\uc558\ub2e4. \uad6d\ub0b4 \ud5c8\uac00\ub97c \ud68d\ub4dd\ud55c \ud751\uc0c9\uc885 \uc801\uc751\uc99d \uc678\uc5d0\ub3c4 \ube44\uc18c\uc138\ud3ec\ud3d0\uc554, \uc804\ub9bd\uc120\uc554, \uc2e0\uc138\ud3ec\uc554, \uac04\uc554 \ub4f1 \uac70\uc758 \ubaa8\ub4e0 \uace0\ud615\uc554\uc5d0 \ub300\ud574 \ub2e8\ub3c5\uc694\ubc95 \uc5f0\uad6c\uac00 \uc9c4\ud589 \uc911\uc774\ub2e4. \ub610\ud55c \ubc18\uc751\ub960\uc744 \uc870\uae08 \ub354 \ub04c\uc5b4\uc62c\ub9ac\uae30 \uc704\ud574 \ub2e4\uc591\ud55c \uc57d\ubb3c \ubcd1\uc6a9\ud6a8\uacfc\ub97c \uac80\uc99d\ud558\uace0 \uc788\ub2e4.<\/p>\n

\uc9c4\ud589\uc131 \uace0\ud615\uc554\uc5d0 \ub300\ud574\uc11c\ub294 \ud56dKIR \uc81c\uc81c\uc778 \uc77c\ub9ac\uc624\ub8f8\ubc14(iliolumbar)\uc640 \ubcd1\uc6a9\ud558\ub294 \uc5f0\uad6c\uac00 \uc9c4\ud589\ub418\uace0 \uc788\uc73c\uba70, \uc704\uc554, \ucdcc\uc7a5\uc554, \uc18c\uc138\ud3ec\uc554 \ubd84\uc57c\uc5d0\uc11c\ub294 CTLA-4 \uba74\uc5ed\uad00\ubb38\uc5b5\uc81c\uc81c\uc778 \uc774\ud544\ub9ac\ubb34\ub9d9(ipilimumab)\uacfc \ubcd1\uc6a9\ud55c \uc5f0\uad6c\uac00 \ud55c\ucc3d\uc774\ub2e4. \uc544\uc6b8\ub7ec \uad50\ubaa8\uc138\ud3ec\uc885\uc5d0 \ub300\ud574\uc11c\ub3c4 \ub2c8\ubcfc\ub8e8\ub9d9\uacfc \uc774\ud544\ub9ac\ubb34\ub9d9\uc758 \uc5f0\uad6c\uac00 \uc9c4\ud589 \uc911\uc778\ub370, \uc774\ub97c \ubca0\ubc14\uc2dc\uc8fc\ub9d9(bevacizumab)\uacfc \ube44\uad50\ud55c\ub2e4.<\/p>\n

\ube44\uc18c\uc138\ud3ec\ud3d0\uc554\uc740 \ub2c8\ubcfc\ub8e8\ub9d9\uc758 \ucc28\uae30 \uc801\uc751\uc99d\uc774 \uc788\ub294 \ub9cc\ud07c \uc5f0\uad6c\uac00 \ud65c\ubc1c\ud558\ub2e4. \uae30\uc874\uc758 \uc82c\uc2dc\ud0c0\ube48\/\uc2dc\uc2a4\ud50c\ub77c\ud2f4(gemcitabine\/cisplatin)\uacfc \uac19\uc740 \ud654\ud559\uc694\ubc95\uacfc \ubcd1\uc6a9\uc740 \uae30\ubcf8\uc774\uace0, \ud37c\uba54\ud2b8\ub809\uc2dc\ub4dc\/\uc2dc\uc2a4\ud50c\ub77c\ud2f4(pemetrexed\/cisplatin), \uce74\ubcf4\ub97c\ub77c\ud2f4\/\ud30c\ud074\ub9ac\ud0c1\uc140(carboplatin\/paclitaxel), \ubca0\ubc14\uc2dc\uc8fc\ub9d9(bevacizumab), \uc5d8\ub85c\ud2f0\ub2d9(erlotinib), \uc774\ud544\ub9ac\ubb34\ub9d9(ipilimumab) \ub4f1 \ub2e4\uc591\ud55c \uc870\ud569\uc758 \uc5f0\uad6c\uac00 \uc9c4\ud589 \uc911\uc774\uc5b4\uc11c \uacfc\uc5f0 \uc5b4\ub5a4 \uc870\ud569\uacfc \ubcd1\uc6a9\ud560 \ub54c \uac00\uc7a5 \ub192\uc740 \ubc18\uc751\ub960\uc744 \uc5bb\uc744 \uc218 \uc788\ub294\uc9c0\uac00 \ud5a5\ud6c4 \uc911\uc694\ud55c \uad00\uc2ec\uc0ac\ub85c \ub5a0\uc624\ub97c \uc804\ub9dd\uc774\ub2e4.<\/p>\n

\uc544\uc6b8\ub7ec \uc544\uc9c1 \uc774\ub807\ub2e4 \ud560 \uce58\ub8cc\uc81c\uac00 \uc5c6\ub294 \uc2e0\uc138\ud3ec\uc554 \ubd84\uc57c\uc5d0\uc11c\ub3c4 \ub2c8\ubcfc\ub8e8\ub9d9\uacfc \uc218\ub2c8\ud2f0\ub2d9(sunitinib), \ud30c\uc870\ud30c\ub2d9(pazopanib), \uc774\ud544\ub9ac\ubb34\ub9d9\uacfc \ubcd1\uc6a9\ud558\ub294 \uc5f0\uad6c\uac00 \ucd94\uc9c4\ub418\uace0 \uc788\ub2e4.<\/p>\n

\uc62c\ud574 \ubbf8\uad6d\uc784\uc0c1\uc885\uc591\ud559\ud68c(ASCO)\uc5d0\uc11c \uc8fc\ubaa9\uc744 \ubc1b\uc558\ub358 \uc5f0\uad6c\ub294 \uac04\uc554\uc5d0\uc11c\uc758 \ub2c8\ubcfc\ub8e8\ub9d9\uc758 \ud6a8\uacfc\uc774\ub2e4. 1\/2\uc0c1 \uc5f0\uad6c(Abstract LBA101)\uac00 \ub098\uc628 \uac83\uc778\ub370 \ud658\uc790\ub4e4\uc758 \uac1d\uad00\uc801 \ubc18\uc751\ub960\uc740 19%\uc600\uace0 \uc608\ube44 1\ub144 \uc804\uccb4 \uc0dd\uc874\uc728\uc774 62%\ub85c \ub098\ud0c0\ub098\uba74\uc11c \uac04\uc554\ubd84\uc57c\uc758 \uc2e0\uc57d\ud0c4\uc0dd\uc744 \uc608\uace0\ud588\ub2e4.<\/p>\n

\u25b6 \ud3a8\ube0c\ub864\ub9ac\uc8fc\ub9d9<\/strong>
\n\uc9c0\ub09c 2\uc6d4 \uad6d\ub0b4\uc5d0\uc11c \ud0a4\ud2b8\ub8e8\ub2e4\ub85c \ud5c8\uac00\ub41c \ud3a8\ube0c\ub864\ub9ac\uc8fc\ub9d9(pembrolizumab)\uc740 \ubbf8\uad6d \uba38\ud06c\uc0ac\uac00 \uac1c\ubc1c\ud55c \uc57d\ubb3c\uc774\ub2e4. \uba38\ud06c\uc0ac\ub294 \uc774 \uc57d\ubb3c\ub85c \uad6d\ub0b4 \ud56d\uc554\uc81c \uc2dc\uc7a5\uc5d0 \ucd9c\uc0ac\ud45c\ub97c \ub358\uc84c\ub2e4. \ud3a8\ube0c\ub864\ub9ac\uc8fc\ub9d9\uc740 \uba38\ud06c\uc0ac\uac00 \ubcf4\uc720\ud55c \uc720\uc77c\ud55c \ud56d\uc554\uc81c\uc778\ub370 \ud55c \uac00\uc9c0 \uc57d\ubb3c\ub85c \uad6d\ub0b4 \ud56d\uc554\uc81c \uc2dc\uc7a5\uc5d0 \ub3c4\uc804\uc7a5\uc744 \ub358\uc9c4 \uac83\uc740 \uc774 \uc57d\ubb3c\uc758 \ubb34\ud55c\ud55c \uac00\ub2a5\uc131 \ub54c\ubb38\uc774\ub2e4.<\/p>\n

\ud604\uc7ac\ub294 \ud751\uc0c9\uc885\uc5d0\ub9cc \ud6a8\uacfc\uac00 \uc785\uc99d\ub410\uc9c0\ub9cc \ub2c8\ubcfc\ub8e8\ub9d9\ucc98\ub7fc \uac70\uc758 \ubaa8\ub4e0 \uc554\uc885\uc5d0\uc11c\uc758 \uc801\uc751\uc99d\uc744 \ud68d\ub4dd\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \uc5f0\uad6c\uac00 \ud65c\ubc1c\ud558\ub2e4.<\/p>\n

\ud2b9\ud788 \ub2c8\ubcfc\ub8e8\ub9d9\uacfc \ub2ec\ub9ac \uc704\uc554, \ub450\uacbd\ubd80\uc554, \uc0bc\uc911\uc74c\uc131 \uc720\ubc29\uc554 \ub4f1 \uc544\uc9c1 \ub9c8\ub545\ud55c \uce58\ub8cc\uc81c\uac00 \uc5c6\ub294 \uc554\uc885\uc5d0 \ub300\ud574 \ud6a8\uacfc\ub97c \uac80\uc99d\ud574 \ud2c8\uc0c8\uc2dc\uc7a5\uc744 \ub178\ub9ac\uaca0\ub2e4\ub294 \uc804\ub7b5\uc774\ub2e4. \ub300\ubd80\ubd84 1\uc0c1\uc784\uc0c1\uc744 \ud1b5\ud574 \uac00\ub2a5\uc131\uc744 \ud655\uc778\ud588\ub2e4.<\/p>\n

\uc544\uc6b8\ub7ec \ube44\uc18c\uc138\ud3ec\ud3d0\uc554 \ud658\uc790\ub4e4\uc744 \ub300\uc0c1\uc73c\ub85c \ub3c4\uc138\ud0c1\uc140\uacfc \ube44\uad50\ud558\ub294 \uc5f0\uad6c\uac00, \uc2e0\uc138\ud3ec\uc554 \ud658\uc790\ub4e4\uc5d0\uac8c\ub294 \ud30c\uc870\ud30c\ub2d9\uacfc \ubcd1\uc6a9\ud558\ub294 \uc5f0\uad6c\uac00 \uc9c4\ud589 \uc911\uc774\ub2e4.<\/p>\n

\uc62c\ud574 ASCO\uc5d0\uc11c \uc8fc\ubaa9\uc744 \ubc1b\uc558\ub358 \uc5f0\uad6c\ub294 \uc9c1\uacb0\uc7a5\uc554 \ud658\uc790\ub4e4\uc744 \ub300\uc0c1\uc73c\ub85c \ud3a8\ube0c\ub864\ub9ac\uc8fc\ub9d9\uc758 2\uc0c1\uc784\uc0c1 \ud6a8\uacfc\uac00 \ub098\uc628 \uac83\uc778\ub370 mis-match repair \uacb0\uc190\uc774 \uc788\ub294 \uacbd\uc6b0 \ub354 \ud6a8\uacfc\uac00 \ub6f0\uc5b4\ub09c \uac83\uc73c\ub85c \ub098\uc640 \uba74\uc5ed\ud56d\uc554\uc81c\uc758 \ud6a8\uacfc\ub97c \uc54c \uc218 \uc788\ub294 \ubc14\uc774\uc624\ub9c8\ucee4\ub97c \ucc3e\uc558\ub2e4\ub294 \ud3c9\uac00\ub3c4 \ubc1b\uace0 \uc788\ub2e4.<\/p>\n\n\n\n\n
<\/td>\n\"\"<\/td>\n<\/td>\n<\/tr>\n
\u25b2 \uc5f0\uad6c\uac00 \uc9c4\ud589\uc911\uc778 PD-1 \uacc4\uc5f4 \uba74\uc5ed\ud56d\uc554\uc81c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u25b6 AMP-224, AMP-514
\n<\/strong>AMP\ub85c \uc2dc\uc791\ud558\ub294 \uc81c\ud488\uc740 \uc544\uc2a4\ud2b8\ub77c\uc81c\ub124\uce74 \uadf8\ub8f9\uc758 \uc790\ud68c\uc0ac\uc778 \uc5e0\ud50c\uc774\ubba8(Amplimmune)\uc774 \uac1c\ubc1c\ud558\uace0 \uc788\ub294 \uc57d\ubb3c\uc774\ub2e4. AMP-224\uc740 PD-1\uacfc B7-H1\uc744 \uc0c1\ud638 \uc791\uc6a9\uc744 \ucc28\ub2e8\ud558\ub294 \ud4e8\uc804 \ud504\ub85c\ud14c\uc778(fusion protein)\uc73c\ub85c \ud604\uc7ac \uae00\ub77d\uc18c \uc2a4\ubbf8\uc2a4\ud074\ub77c\uc778\uacfc \uacf5\ub3d9 \uac1c\ubc1c\ud558\uace0 \uc788\ub2e4. \uc5ec\ub7ec \uac00\uc9c0 \uc554\uacfc \ub9cc\uc131 \uac10\uc5fc\uc9c8\ud658\uc5d0 \ub300\ud574 \ud6a8\uacfc\ub97c \ud655\uc778\ud588\uace0, \ud604\uc7ac 1\uc0c1\uc784\uc0c1 \ub2e8\uacc4\ub2e4. \uc544\uc6b8\ub7ec PD-1 \uacc4\uc5f4\uc758 \uc57d\ubb3c\ub85c AMP-514\ub3c4 \uac1c\ubc1c \uc911\uc778\ub370, \ud604\uc7ac \ub3c5\uc131\uc5f0\uad6c\uac00 \uc9c4\ud589\ub418\uace0 \uc788\ub2e4.<\/p>\n

\u25b6 \ud53c\ub51c\ub9ac\uc8fc\ub9d9<\/strong>
\n\ud53c\ub51c\ub9ac\uc8fc\ub9d9\uc740 \ud050\uc5b4\ud14d\uc0ac\uac00 \uac1c\ubc1c\ud55c PD-1 \uacc4\uc5f4\uc758 \uba74\uc5ed\ud56d\uc554\uc81c\ub2e4.
\n\ubc31\ud608\ubcd1, \ud751\uc0c9\uc885, \ud3d0\uc554, \uc720\ubc29\uc554, \uc9c1\uc7a5\uc554, \ub4f1\uc5d0\uc11c \uac00\ub2a5\uc131\uc744 \ud655\uc778\ud558\uace0 \uc5f0\uad6c\uac00 \ud55c\ucc3d\uc774\ub2e4. 1\uc0c1\uc784\uc0c1\uc5d0\uc11c \ud608\uc561\uc554 \ud658\uc790\uc5d0 \ub300\ud55c \ud6a8\uacfc\ub97c \ud655\uc778\ud588\uace0, 2\uc0c1\uc784\uc0c1\ub3c4 \uc644\ub8cc\ud558\uba74\uc11c \ud608\uc561\uc554\uc5d0\uc11c\uc758 \uba74\uc5ed\uc5b5\uc81c\uc81c \uce58\ub8cc \uac00\ub2a5\uc131\uc744 \uc5f4\uc600\ub2e4.<\/p>\n

2\uc0c1\uc784\uc0c1\uc5d0\uc11c \uc790\uac00\uc720\ub798 \uc904\uae30\uc138\ud3ec\ub97c \uc774\uc2dd\ud55c \ud070 B-\uc138\ud3ec \ub9bc\ud504\uc885(diffuse large B-cell lymphoma) \ud658\uc790\uc758 \ubb34\uc9c4\ud589 \uc0dd\uc874\uc728\uc740 72%\uc600\uc73c\uba70, \uc804\uccb4 \uc0dd\uc874\uc728\uc740 82%\uc774\ub2e4. \uadf8 \uc678\uc5d0 \uc804\uc774\uc131 \uc9c1\uacb0\uc7a5\uc554 \ud658\uc790\uc640 \uc804\uc774\uc131 \ud751\uc0c9\uc885 \ud658\uc790\uc5d0 \ub300\ud55c 2\uc0c1\uc784\uc0c1 \ubaa8\uc9d1\uc774 \uc644\ub8cc\ub410\uc73c\uba70, \ucd94\uac00\ub85c \uc9c4\ud589\ub418\ub294 \ud608\uc561\uc554\uacfc \uace0\ud615\uc554\uc5d0 \ub300\ud55c \uc5f0\uad6c\uac00 \ucd94\uc9c4\ub418\uace0 \uc788\ub2e4.<\/p>\n

PD-L1 \uacc4\uc5f4<\/p>\n

PD-L1 \uacc4\uc5f4\uc5d0\uc11c\ub294 BMS-936559, MEDI4736, MPDL3280A, MSB0010718C \ub4f1\uc774 \uac1c\ubc1c\ub418\uace0 \uc788\ub2e4.<\/p>\n

\u25b6 BMS-936559<\/strong>
\nBMS-936559\ub294 \ube0c\ub9ac\uc2a4\ud1a8\ub9c8\uc774\uc5b4\uc2a4\ud034\ube0c\uc0ac(BMS)\uac00 \uac1c\ubc1c \uc911\uc778 \uc57d\ubb3c\ub85c, PD-L1\uc774 PD-1\uacfc CD80\uc5d0 \uacb0\ud569\ud558\ub294 \uae30\uc804\uc744 \uac16\uace0 \uc788\ub2e4.<\/p>\n

\ud604\uc7ac \uc9c4\ud589\uc131 \uc554 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uac00\ub2a5\uc131\uc744 \uc785\uc99d\ud55c \uc0c1\ud0dc\ub2e4. \uc9c0\ub09c 2012\ub144 ASCO \ubc1c\ud45c\uc640 \ub3d9\uc2dc\uc5d0 NEJM\uc5d0 BMS-936559\uc758 \uacb0\uacfc\uac00 \uc2e4\ub9b0 \ubc14 \uc788\ub294\ub370, \ud751\uc0c9\uc885 \ud658\uc790\uc758 \uac1d\uad00\uc801 \ubc18\uc751\ub960(ORR)\uc740 17%, \uc2e0\uc7a5\uc554\uc5d0\uc11c\ub294 12%\uc600\ub2e4. \ub610 \ube44\uc18c\uc138\ud3ec\ud3d0\uc554\uc5d0\uc11c\ub294 10%\uc600\uc73c\uba70, \ub09c\uc18c\uc554\uc5d0\uc11c\ub294 6%\ub97c \ubcf4\uc774\uace0 \uc788\ub2e4. \ud604\uc7ac 1\uc0c1\uc784\uc0c1\uc774 \uc644\ub8cc\ub410\ub2e4.<\/p>\n

\u25b6 MEDI4736
\n<\/strong>MEDI4736\uc740 \uc544\uc2a4\ud2b8\ub77c\uc81c\ub124\uce74\uac00 \uac1c\ubc1c \uc911\uc778 PD-L1 \uacc4\uc5f4\uc758 \uba74\uc5ed\ud56d\uc554\uc81c\ub85c \ub2e4\uc591\ud55c \uace0\ud615\uc554\uc885\uc5d0\uc11c \ud6a8\uacfc\ub97c \ud655\uc778\ud588\ub2e4. \uc774\ub97c \ud1b5\ud574 \uc9c0\ub09c\ud574 5\uc6d4\ubd80\ud130 \ube44\uc18c\uc138\ud3ec\ud3d0\uc554\ud658\uc790(NSCLC)\ub97c \ub300\uc0c1\uc73c\ub85c 3\uc0c1\uc744 \uc2dc\uc791\ud588\ub2e4. \uc5f0\uad6c\uba85\uc740 PACIFIC\uc73c\ub85c \ubc29\uc0ac\uc120 \uce58\ub8cc\ub97c \ud55c \uc808\uc81c\ubd88\uac00\ub2a5, \uc804\uc774\ub41c \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \uc704\uc57d\uacfc \ube44\uad50\ud558\uac8c \ub41c\ub2e4. \uc544\uc2a4\ud2b8\ub77c\uc81c\ub124\uce74\uac00 \uac1c\ubc1c\ud558\ub294 \uba74\uc5ed\ud56d\uc554\uc81c\uc758 \uccab 3\uc0c1\uc5f0\uad6c\uc774\uae30\ub3c4 \ud558\ub2e4.<\/p>\n

\u25b6 MPDL3280A
\nMPDL3280A\ub294 \ub85c\uc288\uadf8\ub8f9\uc758 \ubc14\uc774\uc624\uc81c\uc57d\uc0ac\uc778 \uc81c\ub128\ud14d\uc774 \uac1c\ubc1c\ud55c \uc791\ud488\uc774\ub2e4. \ud751\uc0c9\uc885, \ube44\uc18c\uc138\ud3ec\ud3d0\uc554, \uc2e0\uc7a5\uc554, \uace0\ud615\uc554 \ub4f1 \ub2e4\uc591\ud55c \uc5f0\uad6c\uac00 \uc9c4\ud589\ub418\uace0 \uc788\uc73c\uba70 \uacb0\uacfc\ub3c4 \uc88b\uc544 \ud5a5\ud6c4 \uba74\uc5ed\ud56d\uc554\uc81c\uc758 \uac15\uc790\ub85c \ud3c9\uac00\ubc1b\uace0 \uc788\ub2e4.<\/p>\n

\uc9c0\uae08\uae4c\uc9c0 \ub098\uc628 \uac1d\uad00\uc801\ubc18\uc751\ub960\uc740 \uc6d0\uaca9 \uc804\uc774 \ubc0f \uc9c4\ud589\uc131 \uace0\ud615\uc554\uc5d0\uc11c 21%\ub97c \ubcf4\uc774\uace0 \uc788\ub2e4. \uc138\ubd80\uc801\uc73c\ub85c \ube44\uc18c\uc138\ud3ec\ud3d0\uc554 \ucf54\ud638\ud2b8 \ud658\uc790\uc5d0\uc11c\ub294 23%, \uc804\uc774\uc131 \ud751\uc0c9\uc885 \ucf54\ud638\ud2b8 \ud658\uc790\uc5d0\uc11c\ub294 26%\ub85c \ub098\uc628 \ubc14 \uc788\ub2e4.<\/p>\n

\ub85c\uc288\ub294 \uc62c\ud574 ASCO\uc5d0\uc11c \ube44\uc18c\uc138\ud3ec\ud3d0\uc554\ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c 2\uc0c1 \uc5f0\uad6c\uc778 POPLAR \uc5f0\uad6c \uacb0\uacfc\ub97c \ubc1c\ud45c\ud588\ub294\ub370 \uc5ec\uae30\uc11c \ub3c4\uc138\ud0c1\uc140\uacfc \ube44\uad50\ud574 \uc804\uccb4 \uc0dd\uc874\uc728\uc744 53%\uac00\ub7c9 \uac1c\uc120\uc2dc\ud0a8 \uac83\uc73c\ub85c \ub098\uc624\uba74\uc11c \ud3d0\uc554\uce58\ub8cc\ub97c \uc774\ub04c \ucc28\uc138\ub300 \uba74\uc5ed\ud56d\uc554\uc81c\ub85c\uc11c\uc758 \uba74\ubaa8\ub97c \uacfc\uc2dc\ud588\ub2e4.<\/p>\n

\uc774 \uc678\uc5d0\ub3c4 \uc2e0\uc7a5\uc554\uc5d0\uc11c\ub3c4 \ubca0\ubc14\uc2dc\uc8fc\ub9d9\uacfc \ubcd1\uc6a9\ud588\uc744 \ub54c \uc218\ub2c8\ud2f0\ub2d9\uacfc \ube44\uad50\ud558\ub294 \uc5f0\uad6c\uac00 \uc9c4\ud589 \uc911\uc774\uba70, \uadf8 \ubc16\uc5d0 \ub2e4\uc591\ud55c \uace0\ud615\uc554\uc5d0\uc11c\ub3c4 \uae30\uc874 \uc57d\uc81c\ub4e4\uacfc \ubcd1\uc6a9\ud588\uc744 \ub54c \uc5bc\ub9c8\ub098 \ud6a8\uacfc\uac00 \ub192\uc740\uc9c0\ub97c \ud3c9\uac00\ud558\uace0 \uc788\ub2e4. \ud604\uc7ac 3\uac1c\uc758 2\uc0c1\uc784\uc0c1\uacfc 6\uac1c\uc758 3\uc0c1\uc784\uc0c1\uc774 \uc21c\ud56d \uc911\uc774\ub2e4.<\/p>\n

\ud55c\ud3b8 \uc62c\ud574 2\uc6d4 FDA\ub85c\ubd80\ud130 \ud601\uc2e0\uc801 \uce58\ub8cc\uc81c\ub85c \uc9c0\uc815\ubc1b\uc558\ub2e4.<\/p>\n\n\n\n\n
<\/td>\n\"\"<\/td>\n<\/td>\n<\/tr>\n
\u25b2 \uc5f0\uad6c\uac00 \uc9c4\ud589\uc911\uc778 PD-L1 \uacc4\uc5f4 \uba74\uc5ed\ud56d\uc554\uc81c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

\u25b6 MSB0010718C(\uc544\ubca8\ub8e8\ub9d9)
\n<\/strong>MSB0010718C\ub294 \uba38\ud06c\uc138\ub85c\ub178\uac00 \uc57c\uc2ec\ucc28\uac8c \uac1c\ubc1c \uc911\uc778 \uba74\uc5ed\ud56d\uc554\uc81c\ub2e4. \uc885\uc591\uc138\ud3ec \ud45c\uba74\uc758 PD-L1\ub97c \uc885\uc591 \ub0b4\ubd80\ub85c \uce68\ud22c\ud560 \uc218 \uc788\ub294 \uba74\uc5ed\uc138\ud3ec\uac00 \ud0d1\uc7ac\ub41c PD-1\uacfc \uacb0\ud569\uc2dc\ud0b4\uc73c\ub85c\uc368 \uba74\uc5ed\uc5b5\uc81c \uc2e0\ud638\uc804\ub2ec \uacfc\uc815\uc5d0\uc11c\uc758 \uad50\ub780\uc744 \uc720\ub3c4\ud560 \uc218 \uc788\uc744 \ubfd0\ub9cc \uc544\ub2c8\ub77c ADCC(Antibody-Dependent Cellular Cytotoxicity: \ud56d\uccb4 \uc758\uc874\uc131 \uc138\ud3ec\ub3c5\uc131 \uc791\uc6a9)\ub97c \uc720\ubc1c\ud558\ub3c4\ub85d \uc124\uacc4\ub3fc \uc788\ub2e4.<\/p>\n

\uc62c\ud574 ASCO\uc5d0\uc11c\ub294 MSB0010718C\uc758 \uc9c4\uba74\ubaa9\uc744 \ubcf4\uc5ec\uc92c\ub2e4\uace0 \ud574\ub3c4 \uacfc\uc5b8\uc774 \uc544\ub2d0 \uc815\ub3c4\ub85c \ub9ce\uc740 \uc5f0\uad6c\uac00 \uc3df\uc544\uc84c\ub2e4. \ubaa8\ub450 10\uac74\uc758 \uc5f0\uad6c\uac00 \uc18c\uac1c\ub410\ub2e4.<\/p>\n

\ub300\ubd80\ubd84 1\uc0c1\uc784\uc0c1\uc758 \ucd08\uae30\uc5f0\uad6c\uac00 \ubc1c\ud45c\ub410\ub294\ub370 \uc804\uc774\uc131 \uba54\ub974\ucf08 \uc138\ud3ec\uc554 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c 2\uc0c1\uc784\uc0c1\ub3c4 \ud3ec\ud568\ub3fc \uc788\ub2e4.<\/p>\n

\ucd08\uae30 \uc784\uc0c1\uc774\uc9c0\ub9cc \uc9c4\ud589\uc131 \ud639\uc740 \uc804\uc774\uc131 \uace0\ud615\uc554(\ube44\uc18c\uc138\ud3ec\ud3d0\uc554, \uc704\uc554, \ub09c\uc18c\uc554, \uc720\ubc29\uc554, \uc545\uc131 \ud751\uc0c9\uc885 \ub4f1) \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \uc548\uc804\uc131\uacfc \ubc0f \ub0b4\uc131\ud3c9\uac00\ub97c \uc785\uc99d\ud588\uace0, \ud2b9\ud788 \uc77c\ubcf8 \uc704\uc554 \ubc0f \uc9c4\ud589\uc131 \uace0\ud615\uc554 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc5f0\uad6c\ub97c \ud1b5\ud574 \uc544\uc2dc\uc544 \ud658\uc790\uc5d0\uc11c\uc758 \uac00\ub2a5\uc131\ub3c4 \ud655\uc778\ud55c \ubc14 \uc788\ub2e4.<\/p>\n

\ubc31\uae08\uae30\ubc18 \ud56d\uc554\ud654\ud559\uc694\ubc95 \uc774\ud6c4 \uc554\uc774 \uc9c4\ud589\ub41c \ube44\uc18c\uc138\ud3ec\ud3d0\uc554 \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c 1\uc0c1\uc784\uc0c1\ub3c4 \ub098\uc654\uace0, \ud56d\uc554 \uce58\ub8cc \uc774\ud6c4 \uc7ac\ubc1c\uc131 \ud639\uc740 \ub09c\uce58\uc131 \ub09c\uc18c\uc554 \ud658\uc790\uc5d0\uc11c \uc2e4\uc2dc\ud55c 1\uc0c1\uc784\uc0c1\ub3c4 \ub098\uc624\uba74\uc11c \ub2e4\uc591\ud55c \uc554\uc885\uc5d0\uc11c\uc758 \uc801\uc751\uc99d \ud655\ub300\ub97c \uc608\uc0c1\ud558\uace0 \uc788\ub2e4.<\/p>\n

\uba74\uc5ed\ud56d\uc554\uc81c \ubd80\uc2a4\ud130
\n<\/strong>\uba74\uc5ed\ud56d\uc554\uc81c\uc758 \ud6a8\uacfc\ub97c \uc99d\uac15\ud558\ub294 \ubd80\uc2a4\ud130 \uc57d\uc81c\ub3c4 \uc788\ub2e4. \ud654\uc774\uc790\uc81c\uc57d\uc774 \uac1c\ubc1c\ud558\ub294 PF-05082566\uc774 \uadf8 \uc8fc\uc778\uacf5\uc774\ub2e4. PF-05082566\uc740 \ub2e8\uc77c\ud074\ub860 \ud56d\uccb4(\uc644\uc804 \uc778\uac04\ud654 mAb)\ub85c \ub2e4\uc218\uc758 \uba74\uc5ed\uc138\ud3ec\uc5d0\uc11c \ubc1c\ud604\ub418\ub294 \ub2e8\ubc31\uc9c8\uc778 4-1BB\ub97c \ud1b5\ud574 \uc2e0\ud638\uc804\ub2ec\uc744 \ucd09\uc9c4\ud558\ub294 \uc815\ub9e5\uc8fc\uc0ac \uc81c\uc81c\uc774\ub2e4.<\/p>\n

4-1BB \ub2e8\ubc31\uc9c8 \uc218\uc6a9\uccb4\ub294 CD8+ T \uc138\ud3ec\uc640 \uac19\uc740 \uc0b4\uc0dd\uc138\ud3ec(killer cell)\uc640 CD4+ T \uc138\ud3ec \ub4f1\uacfc \uac19\uc740 T \uc138\ud3ec\uc5d0\uc11c \ubc1c\uacac\ub418\ub294\ub370 PF-2566\uc774 4-1BB\uc640 \uacb0\ud569\ud560 \ub54c \uba74\uc5ed\uc138\ud3ec\uc758 \uc0dd\uc131\uc744 \ucd09\uc9c4\ud558\uace0 \uba74\uc5ed\uc138\ud3ec\uc758 \uc218\ub97c \uc99d\uac00\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \uc784\uc0c1\uc5d0\uc11c \ud655\uc778\ub418\uba74\uc11c \uc885\uc591\uc5d0 \ub300\ud55c \uba74\uc5ed\uae30\ub2a5\uc744 \ud5a5\uc0c1\uc2dc\ud0ac \uc218 \uc788\ub294 \uac83\uc73c\ub85c \uae30\ub300\uac00 \ub192\uc740 \uc57d\ubb3c\uc774\ub2e4.<\/p>\n

\uc62c\ud574 ASCO\uc5d0\uc11c \uc7ac\ubc1c\uc131 \ud639\uc740 \ub09c\uce58\uc131 CD20+ NHL(\ube44\ud638\uc9c0\ud0a8 \ub9bc\ud504\uc885) \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c PF-2566\uacfc \ub9ac\ud22d\uc2dc\ub9d9(rituximab)\uc744 \ubcd1\uc6a9 \ud22c\uc5ec\ud55c 1\uc0c1\uc784\uc0c1 \uc5f0\uad6c \uacb0\uacfc\uac00 \ub098\uc654\ub294\ub370 \ucd94\uac00 \ub3c5\uc131 \uc5c6\uc774 \ud56d\uc554 \ud6a8\uacfc\ub97c \ucd09\uc9c4\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4.<\/p>\n

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http:\/\/www.hani.co.kr\/arti\/science\/science_general\/836699.html<\/p>\n

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\u2018\uc554\uc138\ud3ec \uc57d\ubb3c\ub0b4\uc131\uc744 \uae68\ub77c\u2019 \uba74\uc5ed\ud56d\uc554\uc81c\uc758 \uce58\uc5f4\ud55c \ub3c4\uc804<\/span><\/h5>\n

<\/p>\n

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\ucd5c\uadfc \u2018CAR-T\u2019 \ub4f1 \uc0c8\ub85c\uc6b4 \uce58\ub8cc\ubc95 \uc8fc\ubaa9<\/p>\n<\/div>\n

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\"\uc554\uc138\ud3ec\ub4e4.<\/div>\n
\uc554\uc138\ud3ec\ub4e4. \ucd9c\ucc98: \uc704\ud0a4\ubbf8\ub514\uc5b4 \ucf54\uba3c\uc2a4<\/div>\n<\/div>\n<\/div>\n

 <\/p>\n

1980~90\ub144\ub300\ub97c \ub3cc\uc544\ubcf4\uba74, \uc0ac\ub78c\ub4e4\uc5d0\uac8c \uc8fd\uc74c\uc758 \uacf5\ud3ec\uc2ec\uc744 \uc77c\uc73c\ud0a8 \ub300\ud45c\uc801\uc778 \uc9c8\ubcd1\uc740 \uc554\uacfc \uc5d0\uc774\uc988(AIDS, \ud6c4\ucc9c \uba74\uc5ed\uacb0\ud54d \uc99d\ud6c4\uad70)\uc600\ub358 \uac83 \uac19\ub2e4. \uce58\ub8cc\uc81c \uac1c\ubc1c\uc758 \uad00\uc810\uc5d0\uc11c \ubcf4\uba74, \uc5d0\uc774\uc988\ub294 \ud604\uc7ac \uad00\ub9ac\uac00 \uac00\ub2a5\ud55c \ubcd1\uc774\ub77c\uace0 \uc0dd\uac01\ud560 \uc815\ub3c4\ub85c \uce58\ub8cc\uc81c \uac1c\ubc1c\uc5d0\uc11c \ub208\ubd80\uc2e0 \uc131\uacf5\uc774 \uc788\uc5c8\ub2e4. \ud558\uc9c0\ub9cc (\uc885\ub958\uc640 \uc6d0\uc778\uc774 \uc6cc\ub099 \ub2e4\uc591\ud55c) \uc554\uc758 \uacbd\uc6b0\uc5d0\ub294 \ub9ce\uc740 \uce58\ub8cc\uc81c\uac00 \uac1c\ubc1c\ub418\uc5c8\uace0 \uce58\ub8cc \ud6a8\uacfc\ub97c \ubcf4\ub294 \uacbd\uc6b0\ub3c4 \ub9ce\uc9c0\ub9cc \uce58\ub8cc\uc5d0 \uc5b4\ub824\uc6c0\uc744 \uacaa\ub294 \uc554\ub3c4 \ub9ce\uae30 \ub54c\ubb38\uc5d0 \uc5ec\uc804\ud788 \uc554 \uc9c8\ud658\uc740 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc5d0\uac8c \uad00\uc2ec\uc758 \ub300\uc0c1\uc774 \ub420 \uc218 \ubc16\uc5d0 \uc5c6\ub2e4.<\/p>\n

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1971\ub144 \ubbf8\uad6d \ub2c9\uc2a8 \uc815\ubd80\uac00 \u201c\uad6d\uac00 \uc554 \ubc95(National Cancer Act)\u201d\uc744 \ud1b5\uacfc\uc2dc\ud0a4\uba70 \uadf8 \uc774\ud6c4 \uc554 \uc815\ubcf5\uc744 \uc704\ud55c \uc608\uc0b0\uc744 2000\uc5b5 \ub2ec\ub7ec \uc774\uc0c1 \uc3df\uc544\ubd80\uc5c8\ub2e4. \uadf8\ub7ec\ub098 2008\ub144 \uc2dc\uc0ac\uc7a1\uc9c0 <\ub274\uc2a4\uc704\ud06c>\uc5d0 \u201c\uc6b0\ub9ac\ub294 \uc554\uacfc\uc758 \uc804\uc7c1\uc5d0\uc11c \uc84c\ub2e4\u201d\ub77c\ub294 \uae00\uc774 \uae30\uace0\ub41c \uac83\ub9cc \ubcf4\ub354\ub77c\ub3c4, \uc554 \uc815\ubcf5\uc744 \uc704\ud55c \uacb0\uacfc\ubb3c\uc774 \ucc98\uc74c \uc608\uc0c1\uacfc \ud070 \ucc28\uc774\uac00 \uc788\uc5c8\uc74c\uc744 \uc27d\uac8c \uc54c \uc218 \uc788\ub2e4. 45\ub144\uc774 \uc9c0\ub09c 2016\ub144 \uc624\ubc14\ub9c8 \uc815\ubd80\uc5d0\uc11c \u201c\uc554\uc815\ubcf5 \uad6d\uac00\uc815\ucc45(National Cancer Moonshot Initiative)\u201d\uc744 \ubc1c\ud45c\ud558\uba70 \ub610 \ub2e4\uc2dc \uc554 \uc815\ubcf5 \uc758\uc9c0\ub97c \ud45c\uba85\ud558\uc600\ub294\ub370, \ub3c4\ub300\uccb4 \uc554 \uce58\ub8cc\uc81c\uc758 \uac1c\ubc1c\uc740 \uc65c \uc774\ub807\uac8c \uc5b4\ub824\uc6b4 \uac83\uc77c\uae4c?\uc0ac\uc2e4 \uc218\ub9ce\uc740 \uc774\uc720\ub4e4\uc774 \uc874\uc7ac\ud558\uc9c0\ub9cc, \uac00\uc7a5 \uc26c\uc6b4 \ub300\ub2f5\uc740 \uc544\ub9c8\ub3c4 \u201c\uc554\uc758 \uc0dd\uba85\ub825, \uadf8\ub9ac\uace0 \uce58\ub8cc\uc5d0 \ub300\ud55c \uc554\uc758 \uc800\ud56d\uc131(\ub0b4\uc131)\u201d\uc774 \uc544\ub2d0\uae4c \uc2f6\ub2e4. \ud604\uc874\ud558\ub294 \ud56d\uc0dd\uc81c\uc5d0 \ub300\ud55c \ub0b4\uc131(\uc800\ud56d\uc131)\uc774 \uac15\ud55c \uc288\ud37c\ubc15\ud14c\ub9ac\uc544\uc758 \ucd9c\ud604\ucc98\ub7fc, \uc554 \uc5ed\uc2dc \ub6f0\uc5b4\ub09c \uc0dd\uba85\ub825\uc744 \uac00\uc9c0\uace0 \uc788\ub2e4. \uc774\ub85c \uc778\ud574 \uc554\uc138\ud3ec\ub294 \uc790\uc2e0\uacfc \uc8fc\ubcc0 \ud658\uacbd\uc744 \ubcc0\ud654\uc2dc\ud0a4\uace0 \uadf8 \uacb0\uacfc\ub85c \uae30\uc874 \uc57d\ubb3c\uc5d0 \ub300\ud55c \ub0b4\uc131\uc744 \ub04a\uc784\uc5c6\uc774 \ub9cc\ub4e4\uc5b4\ub0b4\uace0 \uc788\ub2e4. \uc57d\ubb3c \uac1c\ubc1c\uc758 \uad00\uc810\uc5d0\uc11c \ubcf4\uc790\uba74 \ud56d\uc554\uce58\ub8cc\uc81c \uac1c\ubc1c \uacfc\uc815\uc740 \uc218\ub9ce\uc740 \ub0b4\uc131\uc744 \ub9cc\ub4e4\uc5b4 \ub0b4\ub294 \uc554\uc758 \uc0dd\uba85\ub825\uacfc \ubc8c\uc774\ub294 \uc804\ud22c\uc778 \uac83\uc774\ub2e4. \uadf8\ub807\ub2e4\uba74 \uc554 \uce58\ub8cc\uc81c \uac1c\ubc1c\uc758 \uacfc\uc815\uc5d0\uc11c \uc2e0\uc57d \uac1c\ubc1c\uc790\ub4e4\uc774 \uacaa\ub294 \u201c\uc554\uc758 \uc0dd\uba85\ub825, \ub0b4\uc131\u201d\uc5d0 \ub300\ud574 \uc774\uc57c\uae30\ud558\uae30 \uc804\uc5d0, \ubc15\ud14c\ub9ac\uc544\ub97c \ud1b5\ud558\uc5ec \u201c\uc0dd\uba85\ub825\uacfc \uba74\uc5ed, \uadf8\ub9ac\uace0 \ub0b4\uc131(\uc800\ud56d\uc131)\u201d\uc5d0 \ub300\ud558\uc5ec \uba3c\uc800 \uac04\ub2e8\ud788 \uc0b4\ud3b4\ubcf4\uc790.\uc57d\ubb3c \ub0b4\uc131\uc758 \uadfc\uc6d0\uc778 \ubc15\ud14c\ub9ac\uc544\uc758 \uc0dd\uba85\ub825<\/b>\ud56d\uc0dd\uc81c\ub294 \ubc15\ud14c\ub9ac\uc544, \uacf0\ud321\uc774 \ub610\ub294 \uc6d0\uc0dd\ub3d9\ubb3c\uacfc \uac19\uc740 \ubbf8\uc0dd\ubb3c(\ubcd1\uc6d0\uade0)\uc758 \uc131\uc7a5\uc744 \uc5b5\uc81c\ud558\ub3c4\ub85d \uac1c\ubc1c\ub41c \uc57d\ubb3c\uc774\ub2e4. \ubcd1\uc6d0\uade0\uc5d0 \uc758\ud55c \uac10\uc5fc\uc99d \uce58\ub8cc\uc640 \uc218\uc220 \ub4f1 \uacfc\uc815\uc5d0\uc11c \uc77c\uc5b4\ub0a0 \uc218 \uc788\ub294 \uac10\uc5fc\uc744 \ucc28\ub2e8\ud558\uae30 \uc704\ud574 \uc0ac\uc6a9\ub41c\ub2e4. \uadf8\ub798\uc11c \ud56d\uc0dd\uc81c\ub294 \ud2b9\uc815\ud55c \uc0dd\ubb3c\ud559\uc801 \uba54\ucee4\ub2c8\uc998\uc744 \uc791\ub3d9\ud574 \ubbf8\uc0dd\ubb3c\uc758 \uc131\uc7a5\uc744 \uc5b5\uc81c\ud55c\ub2e4. \ud558\uc9c0\ub9cc \ub2f9\ud558\ub294 \ucc98\uc9c0\uc778 \ubbf8\uc0dd\ubb3c\uc758 \uad00\uc810\uc5d0\uc11c \ubcf4\uba74 \uadf8\uac83\uc740 \uc790\uc2e0\uc758 \uc0dd\uc874\uc744 \uc704\ud611\ud558\ub294 \ucc99\ubc15\ud55c \ud658\uacbd\uc774\uba70 \uc0dd\uc874\uc744 \uc704\ud574 \uadf9\ubcf5\ud574\uc57c \ud558\ub294 \uc704\ud0dc\ub85c\uc6b4 \uc0c1\ud669\uc778 \uc148\uc774\ub2e4.\ub530\ub77c\uc11c \ubbf8\uc0dd\ubb3c \uc138\uacc4\uc5d0\uc11c\ub294 \uc57d\ubb3c\uc5d0 \ub300\ud55c \ub0b4\uc131\uc774 \uc0c1\ub300\uc801\uc73c\ub85c \uac15\ud55c \uc720\uc804\uc790\ub97c \uc774\ubbf8 \uac00\uc9c0\uace0 \uc788\ub358 \uac1c\uccb4\ub4e4\uc774 \uc0dd\uc874\ud558\uac70\ub098, \ub3cc\uc5f0\ubcc0\uc774\ub97c \ud1b5\ud574\uc11c \ub0b4\uc131\uc744 \ud68d\ub4dd\ud568\uc73c\ub85c\uc368 \uc5b4\ub824\uc6b4 \ud658\uacbd\uc744 \uadf9\ubcf5\ud558\uace0 \uc0dd\uc874\ud558\uac8c \ub41c\ub2e4. \uadf8\ub798\uc11c \ud2b9\uc815 \ud56d\uc0dd\uc81c\uc5d0 \ub300\ud55c \ub0b4\uc131\uc774 \uac15\ud574\uc9c4 \ubcd1\uc6d0\uade0\ub4e4\uc774 \uc0dd\uaca8\ub098\uace0 \uc774\ub97c \uce58\ub8cc\ud558\uae30 \uc704\ud574\uc11c\ub294 \ub610 \ub2e4\ub978 \ud2b9\uc815 \uba54\ucee4\ub2c8\uc998\uc73c\ub85c \uc791\ub3d9\ud558\ub294 \uc0c8\ub85c\uc6b4 \ud56d\uc0dd\uc81c\uac00 \ud544\uc694\ud574\uc9c4\ub2e4.\uacb0\uad6d \ud604\uc7ac \uc874\uc7ac\ud558\ub294 \ubaa8\ub4e0 \ud56d\uc0dd\uc81c\uc5d0 \ub0b4\uc131\uc774 \uc788\ub294 \ubc15\ud14c\ub9ac\uc544(\ubbf8\uc0dd\ubb3c)\uac00 \uc0dd\uaca8\ub098\uac8c \ub418\ub294\ub370, \uadf8\uac83\uc774 \ubc14\ub85c \ub274\uc2a4\ub97c \ud1b5\ud574 \uc885\uc885 \ub4e3\ub294 \u2018\uc288\ud37c\ubc15\ud14c\ub9ac\uc544\u2019\ub2e4. \ubbf8\uc0dd\ubb3c\uc758 \uc0dd\uc874\uc774\ub77c\ub294 \uad00\uc810\uc5d0\uc11c \ubcf8\ub2e4\uba74, \uc774\ub4e4\uc758 \uc0dd\uba85\ub825\uc774 \uc5bc\ub9c8\ub098 \uac15\ub825\ud55c\uac00\ub97c \uc0c8\uc0bc \ub290\ub084 \uc218 \uc788\ub294 \uc21c\uac04\uc774\ub2e4.\uba74\uc5ed\uacfc \ubc15\ud14c\ub9ac\uc544\uc758 \uce58\uc5f4\ud55c \u2018\ucca0 \uc904\ub2e4\ub9ac\uae30\u2019<\/b>\ud558\uc9c0\ub9cc \uac15\ub825\ud55c \uc0dd\uba85\ub825\uc740 \uc6b0\ub9ac\uc5d0\uac8c\ub3c4 \uc788\ub2e4. \uc774\ub97c \uc99d\uba85\ud558\ub4ef\uc774 \uc6b0\ub9ac\uac00 \uac00\uc9c0\uace0 \uc788\ub294 \uba74\uc5ed \uc2dc\uc2a4\ud15c\ub3c4 \uc6b0\ub9ac \uc0dd\uba85\uc744 \uc720\uc9c0\ud558\uae30 \uc704\ud574\uc11c \uce58\uc5f4\ud55c \ud65c\ub3d9\uc744 \ud55c\ub2e4. \ub530\ub77c\uc11c \ubc15\ud14c\ub9ac\uc544\uac00 \uc219\uc8fc(\uc778\uac04)\uc5d0 \uce68\uc785\ud55c \uc774\ud6c4\uc5d0 \ubc15\ud14c\ub9ac\uc544\uc640 \uc778\uac04 \uba74\uc5ed \uccb4\uacc4\ub294 \uc11c\ub85c \uac01\uc790\uc758 \uc0dd\uc874\uc744 \uc704\ud574\uc11c \uce58\uc5f4\ud55c \uc2f8\uc6c0\uc744 \ubc8c\uc774\ub294\ub370, \uc774\ub97c \uadf9\uba85\ud558\uac8c \ud655\uc778\ud560 \uc218 \uc788\ub294 \uc88b\uc740 \uc608\uac00 \ubc14\ub85c \u2018\ucca0 \uc904\ub2e4\ub9ac\uae30\u2019\uc774\ub2e4.\ub300\ubd80\ubd84\uc758 \uc0ac\ub78c\ub4e4\uc774 \uc54c\uace0 \uc788\ub4ef\uc774 \ucca0(iron)\uc740 \ud544\uc218 \uc601\uc591\uc18c\ub85c\uc11c \ud5e4\ubaa8\uae00\ub85c\ube48\uc5d0 \uacb0\ud569\ud558\uc5ec \uc0b0\uc18c\ub97c \uc6b4\ubc18\ud558\ub294 \uae30\ub2a5\uc744 \ud55c\ub2e4. \uadf8\ub7ec\ub098 \uc0dd\uba85 \uc720\uc9c0\ub97c \uc704\ud55c \ucca0\uc758 \uc5ed\ud560\uc740 \ud6e8\uc52c \ub2e4\uc591\ud558\uba70 \uc5d0\ub108\uc9c0 \ub300\uc0ac\uacfc\uc815\uc5d0\uc11c\ub3c4 \uc911\uc694\ud558\uac8c \uc0ac\uc6a9\ub418\uace0, \ucca0-\ud669 \ud074\ub7ec\uc2a4\ud130(iron-sulfur cluster)\uc758 \ud615\ud0dc\ub85c \uc5ec\ub7ec \uac00\uc9c0 \uc791\uc6a9\ub4e4\uc5d0 \uad00\uc5ec\ud558\ub294 \ub4f1 \ub2e4\uc591\ud55c \uc5ed\ud560\uc744 \ud558\ub294 \ud544\uc218 \uc601\uc591\uc18c\uc774\ub2e4.<\/p>\n

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\"\uadf8\ub9bc1.<\/div>\n
\uadf8\ub9bc1. \uba74\uc5ed\uacfc \ubc15\ud14c\ub9ac\uc544 \uc0ac\uc774\uc5d0 \ubc8c\uc5b4\uc9c0\ub294 \u201c\ucca0 \uc904\ub2e4\ub9ac\uae30\u201d. \ucd9c\ucc98: Trends Mol Med. 2016 Dec;22(12): 1077-1090.<\/div>\n<\/div>\n<\/div>\n

 <\/p>\n

\uadf8\ub7f0 \uae4c\ub2ed\uc5d0 \uac10\uc5fc \uc911\uc5d0 \uc219\uc8fc(\uc778\uac04)\uc640 \ubc15\ud14c\ub9ac\uc544 \ubcd1\uc6d0\uade0 \uc0ac\uc774\uc5d0\uc11c\ub294 \ucca0 \ud68d\ub4dd\uc744 \uc704\ud55c \uaca9\ub82c\ud55c, \uc0dd\uc874\uc744 \uc704\ud55c \uc2f8\uc6c0\uc774 \uc77c\uc5b4\ub09c\ub2e4(\uadf8\ub9bc1<\/b>). \uc219\uc8fc(\uc778\uac04)\ub294 \ucca0\uc744 \ube7c\uc557\uae30\uc9c0 \uc54a\uae30 \uc704\ud574\uc11c \ucca0\uacfc \uacb0\ud569\ud558\uc5ec \uc6b4\ubc18\ud560 \uc218 \uc788\ub294 \ub2e8\ubc31\uc9c8(Lactoferrin)\uc744 \uc774\uc6a9\ud558\uc5ec \ucca0\uc744 \uc6b4\ubc18\ud55c\ub2e4(\uadf8\ub9bc\uc5d0\uc11c Stage 1). \ud558\uc9c0\ub9cc \ubc15\ud14c\ub9ac\uc544\ub294 \uc0ac\uc774\ub4dc\ub85c\ud3ec\uc5b4(siderophores)\ub77c\uace0 \ubd88\ub9ac\ub294 \u2018\uc791\uc740 \ucca0 \uacb0\ud569 \ubd84\uc790\u2019\ub97c \ubd84\ube44\ud558\uc5ec \ucca0\uc744 \ube7c\uc557\uc544\uc628\ub2e4(Stage 2). \uc774\uc5d0 \ub300\uc751\ud558\uc5ec \uc219\uc8fc(\uc778\uac04) \uba74\uc5ed \uc138\ud3ec\ub294 \ucca0\ubd84\uacfc \uacb0\ud569\ud55c \uc0ac\uc774\ub4dc\ub85c\ud3ec\uc5b4\uac00 \ubc15\ud14c\ub9ac\uc544\uc5d0 \ub2e4\uc2dc \ud761\uc218\ub418\ub294 \uac83\uc744 \ub9c9\uae30 \uc704\ud574 \uc0ac\uc774\ub4dc\ub85c\ud3ec\uc5b4\uc640 \uacb0\ud569\ud558\ub294 \ub2e8\ubc31\uc9c8\uc778 \u2018\ub9ac\ud3ec\uce7c\ub9b0 2\u2019(Lcn2, lipocalin 2, \uc0ac\uc774\ub370\ub85c\uce7c\ub9b0(siderocalin))\ub97c \ubd84\ube44\ud558\ub294\ub370(Stage 3), \uc774 \ub2e8\ubc31\uc9c8\uc740 \ucca0\ubd84\uacfc \uacb0\ud569\ud55c \ubc15\ud14c\ub9ac\uc544\uc758 \uc0ac\uc774\ub4dc\ub85c\ud3ec\uc5b4\ub97c \ud1b5\uc9f8\ub85c \uacb0\ud569\ud558\ub294 \ubc29\ubc95\uc73c\ub85c \uc77c\uc885\uc758 \u2018\ub0a9\uce58\u2019\ub97c \ud55c\ub2e4. \uc774 \uc704\ud611\uc5d0 \ub2e4\uc2dc \ub300\uc751\ud558\uae30 \uc704\ud574 \uc77c\ubd80 \ubc15\ud14c\ub9ac\uc544\ub294 \ucca0 \uacb0\ud569 \ubd84\uc790\uc778 \uc0ac\uc774\ub4dc\ub85c\ud3ec\uc5b4 \ub05d\uc5d0 \ub2f9\ubd84\uc790(carbohydrate)\ub97c \ub2ec\uc544\uc11c \ub9ac\ud3ec\uce7c\ub9b0 2\uac00 \uacb0\ud569\/\ub0a9\uce58\ub97c \ubabb\ud558\uac8c \ud558\ub294 \ub0b4\uc131\uc774 \uc0dd\uae30\ub3c4\ub85d \uc774\uc6a9\ud55c\ub2e4(Stage 4).\ucc38\uc73c\ub85c \uce58\uc5f4\ud55c, \uc0dd\uc874\uc744 \uc704\ud55c \uc804\uc7c1 \uac19\uc740 \uc904\ub2e4\ub9ac\uae30\ub2e4. \uc774\ub807\uac8c \uce58\uc5f4\ud55c \uc804\uc7c1\uc774 \ubc8c\uc5b4\uc9c0\ub294 \uc774\uc720\ub294 \ubd84\uba85 \u201c\uc0dd\uc874\/\uc0dd\uba85\ub825\u201d\uc774\ub2e4. \ubc15\ud14c\ub9ac\uc544\ub3c4 \uc0dd\uc874\uc744 \uc704\ud574\uc11c\ub294 \ucca0\ubd84\uc744 \uc5bb\uc5b4\uc57c \ud558\uace0, \uc778\uac04\ub3c4 \ubcd1\uc6d0\uade0\uc758 \uac10\uc5fc\uc73c\ub85c \ubcd1\ub4e4\uc9c0 \uc54a\uae30 \uc704\ud574\uc11c\ub294 \ucca0\ubd84\uc744 \ube7c\uc557\uae30\uc9c0 \uc54a\uc544\uc57c \ud558\ub2c8\uae4c \ub9d0\uc774\ub2e4.\ud56d\uc554 \uce58\ub8cc\uc81c \uc57d\ubb3c\ub0b4\uc131\uc758 \uc5ec\ub7ec \uc6d0\uc778\ub4e4<\/b>\uc5bc\ub9c8 \uc804 \ud654\uc81c\uac00 \ub418\uc5c8\ub358 \u201c\uc554\uc138\ud3ec\ub3c4 \uc0dd\uba85\uc774\ub2e4\u201d\ub77c\ub294, \uc5b4\ub290 \ub4dc\ub77c\ub9c8 \uc18d \ub300\uc0ac\ub97c \uc0dd\uba85\ub825\uc758 \uad00\uc810\uc5d0\uc11c\ub9cc \ubcf8\ub2e4\uba74, \uc554\uc138\ud3ec\uac00 \uc704\uc5d0\uc11c \uc0b4\ud3b4\ubcf8 \ubc15\ud14c\ub9ac\uc544\uc5d0 \ubabb\uc796\ub2e4\ub294 \uc810\uc5d0\uc11c \ucda9\ubd84\ud788 \uacf5\uac10\ud560 \ub9cc\ud558\ub2e4. \uc57d\ubb3c\uc5d0 \ub300\ud55c \ub0b4\uc131 \ub54c\ubb38\uc5d0 \uc0c8\ub85c\uc6b4 \uce58\ub8cc\uc81c\uac00 \ud544\uc694\ud55c \ubd84\uc57c\uac00 \ubc14\uc774\ub7ec\uc2a4\ub098 \ubc15\ud14c\ub9ac\uc544 \uac10\uc5fc\ubfd0\ub9cc \uc544\ub2c8\ub77c \uc554\uc5d0\ub3c4 \ud574\ub2f9\ud558\ub294 \uac83\ub3c4 \uc774 \ub54c\ubb38\uc774\ub2e4.<\/p>\n

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\"\uadf8\ub9bc<\/div>\n
\uadf8\ub9bc 2. \uc57d\ubb3c\ub0b4\uc131\uc758 \uc5ec\ub7ec \uc6d0\uc778\ub4e4. \uc554\uc774 \uc57d\ubb3c\uc5d0 \ub0b4\uc131\uc744 \ub744\ub294 \ubc29\ubc95\uc740 \ub2e4\uc591\ud558\uc9c0\ub9cc, \ubcf8\ubb38\uc5d0\uc11c\ub294 \uc57d\ubb3c\uc758 \ubd88\ud65c\uc131\ud654\uc640 \uc57d\ubb3c\ud45c\uc801 \ubcc0\ud615\uc5d0 \ub300\ud574\uc11c\ub9cc \uc124\uba85\ud558\uc600\ub2e4. \ucd9c\ucc98: Cancers 2014, 6, 1769-1792.<\/div>\n<\/div>\n<\/div>\n

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\uc554\uc138\ud3ec\uc5d0 \uc57d\ubb3c \ub0b4\uc131\uc774 \uc0dd\uae30\ub294 \uc774\uc720\ub4e4\uc740 \ub2e4\uc591\ud558\ub2e4. \ub9ce\uc740 \ud56d\uc554\uc81c\uac00 \uc57d\ubb3c \ud6a8\uacfc\ub97c \ub0b4\uae30 \uc704\ud574 \uc2e0\uc9c4\ub300\uc0ac \ud65c\uc131\ud654 \uacfc\uc815\uc744 \uc77c\uc73c\ucf1c\uc57c \ud558\ub294\ub370, \uc554\uc740 \uc774 \uc2e0\uc9c4\ub300\uc0ac \ud65c\uc131\ud654\ub97c \uac10\uc18c\uc2dc\ud0b4\uc73c\ub85c\uc368 \uacb0\uad6d\uc5d0 \uc57d\ubb3c \ud6a8\uacfc\ub97c \uac10\uc18c\uc2dc\ud0a4\ub294 \ub0b4\uc131\uc744 \ub760\uac8c \ub41c\ub2e4.\uc608\ub97c \ub4e4\uc5b4\uc11c \uae09\uc131 \uace8\uc218\uc131 \ubc31\ud608\ubcd1\uc758 \uce58\ub8cc\uc5d0 \uc0ac\uc6a9\ub418\ub294 \uc57d\ubb3c\uc778 \uc0ac\uc774\ud0c0\ub77c\ube48(cytarabine; AraC)\uc740 \uc2e0\uc9c4\ub300\uc0ac\ub97c \ud1b5\ud574\uc11c \uc0bc\uc778\uc0b0 \uc0ac\uc774\ud0c0\ub77c\ube48(AraC-triphosphate)\uc73c\ub85c \ubcc0\ud658\ub418\uc5b4\uc57c \uc57d\ubb3c \ud6a8\uacfc\uac00 \ub098\ud0c0\ub09c\ub2e4. \uc774 \ub54c\ubb38\uc5d0 \uc554\uc5d0 \uc758\ud574\uc11c \uc778\uc0b0\ud654\uc5d0 \uad00\uc5ec\ub418\ub294 \uacbd\ub85c\uc5d0 \ub3cc\uc5f0\ubcc0\uc774\uac00 \uc0dd\uc131\ub418\uac70\ub098 \uc774 \ub300\uc0ac\uc758 \ud65c\uc131\ud654\uac00 \uac10\uc18c\ub418\uba74 \uc774 \uc57d\ubb3c\uc758 \ub0b4\uc131\uc774 \uc0dd\uae38 \uc218 \uc788\ub294 \uac83\uc774\ub2e4.\ub610 \ub2e4\ub978 \uc57d\ubb3c \ub0b4\uc131\uc758 \uc6d0\uc778\uc73c\ub85c \uc57d\ubb3c \ud45c\uc801 \uc790\uccb4\uc758 \ubcc0\ud615\uc744 \ub4e4 \uc218 \uc788\ub2e4. \uc57d\ubb3c\uc758 \uae30\ubcf8 \uc6d0\ub9ac\ub294 \ud45c\uc801\uc73c\ub85c \uc0bc\ub294 \ubd84\uc790\uc5d0 \uc815\ud655\ud788 \uacb0\ud569\ud574 \uc9c8\ud658\uacfc \uad00\ub828\ub41c \uadf8 \uc57d\ubb3c \ud45c\uc801\uc758 \ud1b5\uc0c1\uc801\uc778 \uc5ed\ud560\uc744 \ub9c9\ub294 \uac83\uc778\ub370, \ub9cc\uc77c \uc57d\ubb3c \ud45c\uc801 \uc790\uccb4\uac00 \ubcc0\ud615\ub3fc \uc57d\ubb3c\uacfc \ud45c\uc801\uc758 \uc120\ud0dd\uc801\uc778 \uacb0\ud569\uc774 \uc57d\ud654\ub418\uba74 \uc57d\ubb3c\uc758 \uc5ed\ud560\uc744 \uac00\ub85c\ub9c9\ub294 \uc57d\ubb3c \ub0b4\uc131\uc774 \uc0dd\uae34\ub2e4. \uac00\uc7a5 \uc26c\uc6b4 \uc608\ub294 \ud3d0\uc554\uce58\ub8cc\uc81c\ub85c \uc0ac\uc6a9\ub418\ub294 \ud45c\ud53c\uc131\uc7a5\uc778\uc790 \uc218\uc6a9\uccb4(EGFR)\ub97c \uc57d\ubb3c \ud45c\uc801\uc73c\ub85c \uc0bc\ub294 \ud0c0\uc774\ub85c\uc2e0 \uce74\uc774\ub098\uc81c \uc800\ud574\uc81c(tyrosine kinase inhibitor) \uc57d\ubb3c\ub4e4\uc774\ub2e4. \uc774 \uc57d\ubb3c\ub85c \uce58\ub8cc\ud558\ub294 \uacbd\uc6b0, 1\ub144\ucbe4 \uc548\uc5d0 \uc57d\ubb3c \ud45c\uc801\uc778 \ud45c\ud53c\uc131\uc7a5\uc778\uc790 \uc218\uc6a9\uccb4\uc5d0 \ubcc0\ud615\uc774 \ub098\ud0c0\ub098 \uc57d\ubb3c \ub0b4\uc131\uc744 \ubcf4\uc774\ub294 \uac83\uc73c\ub85c \uc54c\ub824\uc838 \uc788\ub2e4.\ubb3c\ub860 \uc5f0\uad6c\uc790\ub4e4\uc740 \ub2e4\uc2dc \uc774\ub7f0 \ubcc0\ud615\uc5d0 \ud6a8\uacfc\ub97c \ub0b4\ub294 \uc0c8\ub85c\uc6b4 \uc57d\ubb3c\uc744 \uac1c\ubc1c\ud558\uace4 \ud558\uc9c0\ub9cc \uc57d\ubb3c\uc5d0 \ub178\ucd9c\ub418\ub294 \uc2dc\uac04\uc774 \uae38\uc5b4\uc9c0\uba74, \uadf8 \uc57d\ubb3c\uc5d0 \ub300\ud574 \ub610 \ub2e4\ub978 \ubcc0\ud615\ub4e4\uc774 \uc0dd\uaca8 \uc57d\ubb3c\uc740 \uc81c\ub300\ub85c \uc791\ub3d9\ud558\uc9c0 \ubabb\ud55c\ub2e4. \uc55e\uc5d0\uc11c \uc598\uae30\ud55c \u2018\ucca0 \uc904\ub2e4\ub9ac\uae30\u2019 \uac19\uc740 \ubc18\ubcf5\ub418\ub294 \uc2f8\uc6c0\uc774 \uc554\uacfc \uc2e0\uc57d \uc5f0\uad6c\uc790\ub4e4 \uc0ac\uc774\uc5d0\uc11c\ub3c4 \uc77c\uc5b4\ub098\uba70, \uc774\ub7ec\ud55c \uae4c\ub2ed\uc73c\ub85c 3\uc138\ub300, 4\uc138\ub300 \uc57d\ubb3c\ub4e4\uc774 \uacc4\uc18d \uc5f0\uad6c\ub418\uace0 \uc788\ub2e4.\uba74\uc5ed\ud56d\uc554\uc81c\uc640 \uc57d\ubb3c \ub0b4\uc131\ub4e4<\/b>\ub9ce\uc740 \ubd84\ub4e4\uc774 \uc5ec\ub7ec \ub9e4\uccb4\ub4e4\uc5d0\uc11c \u2018\uba74\uc5ed\ud56d\uc554\uc81c\u2019\uc5d0 \uad00\ud55c \uc598\uae30\ub97c \ud55c \ubc88\ucbe4\uc740 \ub4e4\uc5b4\ubd24\uc744 \uac83\uc73c\ub85c \uc0dd\uac01\ub41c\ub2e4. \ucd5c\uadfc \uc5ec\ub7ec \uac00\uc9c0\uc758 \uce58\ub8cc\uc81c\ub4e4\uc774 \uc784\uc0c1\uc5d0\uc11c \uc88b\uc740 \uce58\ub8cc \uacb0\uacfc\ub97c \ubcf4\uc600\uace0, \ubbf8\uad6d\uc2dd\ud488\uc758\uc57d\uad6d(FDA) \ud5c8\uac00\ub97c \ubc1b\uc558\uc73c\uba70, \uc774\uc81c\ub294 \ud56d\uc554 \uce58\ub8cc\uc5d0\uc11c \ud070 \ud750\ub984\uc774 \uba74\uc5ed\ud56d\uc554\uc81c\ub85c \uc774\ubbf8 \ub118\uc5b4\uac00\uace0 \uc788\ub2e4\uace0 \ud574\ub3c4 \uacfc\uc7a5\uc740 \uc544\ub2d0 \uac83 \uac19\ub2e4.\uae30\uc874\uc758 \ud56d\uc554\uc81c\ub4e4\uacfc \ub2ec\ub9ac \uba74\uc5ed\ub825\uc744 \uc62c\ub824\uc11c \uc554\uc744 \uce58\ub8cc\ud558\uace0\uc790 \uac1c\ubc1c\ub418\ub294 \uba74\uc5ed\ud56d\uc554\uc81c\uc5d0\uc11c\ub294 \uc704\uc5d0\uc11c \uc5b8\uae09\ud55c \uc57d\ubb3c \ub0b4\uc131\uc774 \uc0dd\uae30\uc9c0 \uc54a\uc744\uc9c0\ub3c4 \ubaa8\ub978\ub2e4\ub294 \uae30\ub300\uac00 \uc788\uc5c8\ub2e4. \u2018\ucca0 \uc904\ub2e4\ub9ac\uae30\u2019\uc5d0\uc11c \ud655\uc778\ud588\ub4ef\uc774 \uba74\uc5ed\uc774 \ud65c\uc131\ud654\ub418\uba74 \uc800\uc808\ub85c 2\ucc28, 3\ucc28\uc758 \ub300\uc751\uc774 \uac00\ub2a5\ud558\ub3c4\ub85d \uc791\ub3d9\ud560 \uac83\uc774\ub77c \ubbff\uc5c8\uae30 \ub54c\ubb38\uc774\ub2e4. \ud558\uc9c0\ub9cc FDA\uc5d0\uc11c \uc2b9\uc778\ub41c \uba74\uc5ed\ud56d\uc554\uc81c\ub4e4\uc5d0\uc11c\ub3c4 \uc57d\ubb3c \ub0b4\uc131\uc774 \ubc1c\uacac\ub418\uae30 \uc2dc\uc791\ud558\uc600\uc73c\uba70, \uc774 \ub54c\ubb38\uc5d0 \uba74\uc5ed\ud56d\uc554\uc81c\uc758 \uac1c\ubc1c \uacfc\uc815\uc5d0\uc11c\ub3c4 \u2018\ucca0 \uc904\ub2e4\ub9ac\uae30\u2019 \uac19\uc774 \ubc18\ubcf5\ub418\ub294 \uc2f8\uc6c0\uc5d0\uc11c \ubc97\uc5b4\ub098\uae30 \uc704\ud55c \uc804\ub7b5\uc774 \ub2e4\uac01\uc801\uc73c\ub85c \uace0\ub824\ub418\uace0 \uc788\ub2e4.\uadf8\ub807\ub2e4\uba74 \uba74\uc5ed\ud56d\uc554\uc81c \uac1c\ubc1c\uacfc \uad00\ub828\ub418\ub294 \uc57d\ubb3c \ub0b4\uc131\uc5d0\ub294 \uc5b4\ub5a4 \uac83\ub4e4\uc774 \uc788\uc744\uae4c?<\/p>\n

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\"\uadf8\ub9bc<\/div>\n
\uadf8\ub9bc 3. \uc784\uc0c1\uc5d0\uc11c \ub098\ud0c0\ub098\ub294 \uc57d\ubb3c\ub0b4\uc131\uc5d0\ub294 \ub2e4\uc591\ud55c \uc6d0\uc778\uc774 \uc788\ub2e4. (A) \ucc98\uc74c\ubd80\ud130 \uba74\uc5ed\uce58\ub8cc\uc5d0 \ud6a8\uacfc\uac00 \uc5c6\ub294 \uacbd\uc6b0, (B) \uba74\uc5ed\uce58\ub8cc\uc5d0 \ubc18\uc751\uc740 \ud558\uc9c0\ub9cc, \uc5ec\ub7ec \uac00\uc9c0 \ub0b4\uc131\uc744 \uc77c\uc73c\ud0a4\ub294 \uba54\ucee4\ub2c8\uc998\ub4e4\uc5d0 \uc758\ud574\uc11c \ud6a8\uacfc\uac00 \ub098\ud0c0\ub098\uc9c0 \uc54a\ub294 \uacbd\uc6b0, (C) \ucc98\uc74c\uc5d0\ub294 \ud6a8\uacfc\ub97c \ubcf4\uc774\uc9c0\ub9cc \uba74\uc5ed\uce58\ub8cc\uc5d0 \ub0b4\uc131\uc774 \uc788\ub294 \uc138\ud3ec\ub4e4\uc774 \uce58\ub8cc \uc774\uc804\ubd80\ud130 \uc788\ub294 \uacbd\uc6b0, (D) \ucd08\uae30\uc5d0 \ud6a8\uacfc\ub97c \ubcf4\uc774\ub2e4\uac00 \uce58\ub8cc\uacfc\uc815 \uc911\uc5d0 \ub0b4\uc131\uc774 \uc0dd\uae30\ub294 \uacbd\uc6b0. \ucd9c\ucc98: Cell. 2017 Feb 9;168(4):707-723.<\/div>\n<\/div>\n<\/div>\n

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\uc0ac\uc2e4 \uc554\uc138\ud3ec\uac00 \uc790\ub77c\uace0 \uc788\ub2e4\ub294 \uac83 \uc790\uccb4\uac00 \uc778\uac04\uc758 \uc77c\uc0c1\uc801\uc778 \uba74\uc5ed \uc2dc\uc2a4\ud15c\uc758 \uac10\uc2dc\ub97c \uc554\uc138\ud3ec\ub4e4\uc774 \uc131\uacf5\uc801\uc73c\ub85c \ud68c\ud53c\ud588\ub2e4\ub294 \uac83\uc774\ub2c8 \uc774\ubbf8 \uc554\uc758 1\ucc28 \uacf5\uaca9(\uba74\uc5ed\uc5d0 \ub300\ud55c \ub0b4\uc131\/\uc800\ud56d\uc131)\uc774 \uc131\uacf5\ud55c \uc0c1\ud0dc\ub77c\uace0 \ubd10\uc57c \ud560 \uac83\uc774\ub2e4. \uba74\uc5ed\uc744 \ud68c\ud53c\ud558\ub294 \ubc29\ubc95\uc740 \ub2e4\uc591\ud558\uc9c0\ub9cc \ud55c \uac00\uc9c0 \uc608\ub97c \uc790\uc138\ud788 \uc0b4\ud3b4\ubcf4\uc790.\uc120\ucc9c\uc801\uc73c\ub85c \uba74\uc5ed\uc740 \uc678\ubd80 \uce68\uc785\uc5d0 \ub300\uc751\ud558\uc5ec \uba74\uc5ed\ubc18\uc751\uc744 \ubcf4\uc774\ub294\ub370, \uadf8 \uba74\uc5ed\ubc18\uc751\uc740 \uc678\ubd80 \uce68\uc785\uc790\uc5d0 \ub300\ud55c \uacb0\ud22c\uac00 \ub05d\ub098\uba74 \uc0ac\ub77c\uc9c0\ub3c4\ub85d \uc124\uacc4\ub418\uc5b4 \uc788\ub2e4. \u2018\ud53c\ub514-\uc5d81(PD-L1)\u2019\uc774\ub77c\ub294 \ub9ac\uac04\ub4dc \ubd84\uc790\ub3c4 \uadf8\ub7f0 \u2018\uba74\uc5ed\ubc18\uc751 \uc5fc\uc99d\uc758 \uc885\ub8cc\u2019 \uc2dc\uc810\uc744 \uc54c\ub824\uc8fc\ub294 \uc2dc\uadf8\ub110\ub85c \uc791\uc6a9\ud55c\ub2e4. \uba74\uc5ed\uc138\ud3ec \ud45c\uba74\uc5d0 \ub098\ud0c0\ub09c PD-L1 \ub9ac\uac04\ub4dc \uc2e0\ud638\uc640 \ub610 \ub2e4\ub978 \uba74\uc5ed\uc138\ud3ec\uc758 \ud45c\uba74\uc5d0 \ub098\ud0c0\ub09c \u2018\ud53c\ub514-1(PD-1)\u2019\uc774\ub77c\ub294 \uc218\uc6a9\uccb4 \ubd84\uc790\uac00 \uacb0\ud569\ud568\uc73c\ub85c\uc368 \u2018\uba74\uc5ed\ubc18\uc751 \uc885\ub8cc\u2019\uac00 \uc774\ub904\uc9c0\ub294 \uac83\uc774\ub2e4.\ud558\uc9c0\ub9cc \uba74\uc5ed\ubc18\uc751\uc744 \ud53c\ud574\uc57c \ud558\ub294 \uc554\uc774 \uc774 \uae30\ub2a5\uc744 \ucc28\uc6a9\ud558\uba74 \uc5b4\ub5bb\uac8c \ub420\uae4c? \uc554\uc138\ud3ec\uac00 PD-L1(\ub9ac\uac04\ub4dc)\ub97c \ubc1c\ud604\uc2dc\ud0a4\uba74, \uba74\uc5ed\uc138\ud3ec\ub4e4\uc740 \uba74\uc5ed\ubc18\uc751 \uc885\ub8cc \uc2e0\ud638\ub85c \uc624\uc778\ud574 \uacf5\uaca9\uc744 \uba48\ucd98\ub2e4. \uadf8\ub7fc\uc73c\ub85c\uc368 \uc554\uc138\ud3ec\ub294 \uba74\uc5ed\uc5d0 \uc758\ud55c \ud56d\uc554 \ud6a8\uacfc\ub97c \ud68c\ud53c\ud560 \uc218 \uc788\ub2e4.FDA\uac00 \ud5c8\uac00\ud55c \uba74\uc5ed\ud56d\uc554\uc81c\uc5d0\ub294 PD-1(\uc218\uc6a9\uccb4)\/PD-L1(\ub9ac\uac04\ub4dc)\uc758 \uacb0\ud569\uc744 \ucc28\ub2e8\ud558\ub294 \ud56d\uccb4\ub4e4\uc774 \uc788\ub294\ub370, \uc774 \ud56d\uccb4\ub4e4\uc740 \uc554\uc138\ud3ec\uac00 PD-L1 \ub9ac\uac04\ub4dc\ub97c \ubc1c\ud604\ud574 \uba74\uc5ed \uac10\uc2dc\ub97c \ud68c\ud53c\ud558\ub294 \uac83\uc744 \ub9c9\ub294 \uae30\ub2a5\uc744 \ud55c\ub2e4. PD-1(\uc218\uc6a9\uccb4)\/PD-L1(\ub9ac\uac04\ub4dc)\uc758 \uacb0\ud569\uc744 \ucc28\ub2e8\ud558\ub294 \ud56d\uccb4\ub4e4\uc774 \uc88b\uc740 \ud6a8\ub2a5\uacfc \ub0ae\uc740 \ubd80\uc791\uc6a9\uc758 \uce21\uba74\uc5d0\uc11c \uc88b\uc740 \uacb0\uacfc\ub97c \ubcf4\uc774\uace0 \uc788\uc9c0\ub9cc, \uc774 \uacbd\uc6b0\uc5d0\ub3c4 \uc804\uccb4\uc801\uc778 \ubc18\uc751\ub960\uc774 15-20%(\uc608\ub97c \ub4e4\uc5b4 \ud3d0\uc554\uc758 \uacbd\uc6b0)\uc5d0 \uba38\ubb34\ub974\uace0 \uc788\uc5b4\uc11c \uadf8 \ud55c\uacc4 \ub610\ud55c \uba85\ud655\ud55c \uc0c1\ud669\uc774\ub2e4.PD-1\/PD-L1 \ucc28\ub2e8 \ud56d\uccb4\uc758 \ud6a8\ub2a5\uacfc \ud55c\uacc4\ub97c \ubaa8\ub450 \uc124\uba85\ud560 \uc218 \uc788\ub294 \ub2e8\uc5b4\uac00 \ubc14\ub85c \ub0b4\uc131\uc774\ub2e4.<\/p>\n

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\"\uadf8\ub9bc<\/div>\n
\uadf8\ub9bc 4. \uba74\uc5ed\uc138\ud3ec\uc778 T\uc138\ud3ec\uc758 \uc8fc\uc0ac\uc804\uc790\ud604\ubbf8\uacbd \uc601\uc0c1. \ud658\uc790\uc758 \ud608\uc561\uc5d0\uc11c \ucd94\ucd9c\ud55c T\uc138\ud3ec\uc758 \uc720\uc804\uc790\ub97c \uccb4\uc678\uc5d0\uc11c \ubcc0\ud615\ud568\uc73c\ub85c\uc368, \uc554\uc138\ud3ec\uc5d0 \ub300\ud56d\ud558\ub294 T\uc138\ud3ec\uc758 \uba74\uc5ed \ub2a5\ub825\uc744 \ub192\uc774\ub294 \uc0c8\ub85c\uc6b4 \ud56d\uc554\uce58\ub8cc\uc220(CAR-T)\uc774 \ucd5c\uadfc \uc8fc\ubaa9\ubc1b\uace0 \uc788\ub2e4. \uc601\uc0c1\ucd9c\ucc98: \uc704\ud0a4\ubbf8\ub514\uc5b4 \ucf54\uba3c\uc2a4.<\/div>\n<\/div>\n<\/div>\n

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\uc5f0\uad6c\ub97c \ud1b5\ud574\uc11c \uc774\ub7ec\ud55c \uc120\ucc9c\uc801\uc778 \ub0b4\uc131\uc744 \uc9c0\ub2cc \uc554\uc758 \uba74\uc5ed \ud68c\ud53c \uc6d0\ub9ac(\uc704\uc5d0\uc11c \uc124\uba85\ud55c \uc554\uc758 1\ucc28 \uacf5\uaca9)\ub97c \ud655\uc778\ud55c \uacfc\ud559\uc790\ub4e4\uc774 \uc554\uc138\ud3ec\uc640 \uba74\uc5ed\uc138\ud3ec \uac04\uc758 \uacb0\ud569\uc744 \ucc28\ub2e8\ud558\ub294 \ud56d\uccb4\ub97c \uac1c\ubc1c\ud55c \uac83\uc740 \uc554\uc758 \uc120\ucc9c\uc801 \ub0b4\uc131(\uba74\uc5ed\uc5d0 \ub300\ud55c \uc800\ud56d\uc131)\uc5d0 \ub300\ud55c \uacfc\ud559\uc790\ub4e4\uc758 \ubc18\uaca9\uc778 \uac83\uc774\ub2e4. \ub610\ud55c \uc81c\ud55c\uc801\uc778 \ubc18\uc751\ub960 \uc5ed\uc2dc \ub610 \ub2e4\ub978 \uc885\ub958\uc758 \ub0b4\uc131 \uba54\uce74\ub2c8\uc998\uc774 \uc791\ub3d9\ud558\uae30 \ub54c\ubb38\uc774\ub2e4.\uadf8\ub807\ub2e4\uba74, PD-1\/PD-L1 \ucc28\ub2e8 \ud56d\uccb4\uc5d0 \uc758\ud55c \uacfc\ud559\uc790\ub4e4\uc758 \ubc18\uaca9 \uc774\ud6c4 \ubaa8\uc2b5\uc740 \uc5b4\ub5a8\uae4c? PD-1 \ud56d\uccb4\uc758 \uce58\ub8cc\uc5d0 \ucd08\uae30 \ud6a8\uacfc\ub97c \ubcf4\uc774\ub358 \ud658\uc790\ub4e4 \uc911 \uc77c\ubd80\uc5d0\uac8c\uc11c \uc810\ucc28 \uac19\uc740 \uc57d\ubb3c\ub85c \ud56d\uc554 \ud6a8\uacfc\ub97c \ubcfc \uc218 \uc5c6\ub294 \uacbd\uc6b0\uac00 \uad00\ucc30\ub418\uc5c8\uace0, \uadf8 \uc6d0\uc778\ub4e4\uc744 \ubd84\uc11d\ud558\uc600\ub294\ub370 \ub300\ub7b5 \ub2e4\uc74c\uacfc \uac19\ub2e4.\uc554\uc138\ud3ec\uac00 PD-1\/PD-L1\uc744 \ud1b5\ud558\uc5ec \uba74\uc5ed\uc138\ud3ec\ub97c \ud68c\ud53c\ud558\ub294 \uac83\uc740 \ud56d\uccb4\ub97c \ud1b5\ud574\uc11c \ub9c9\uc558\uc9c0\ub9cc, \uc554\uc138\ud3ec\ub294 \ub610 \ub2e4\ub978 \uba54\ucee4\ub2c8\uc998\uc744 \uc774\uc6a9\ud55c \ub0b4\uc131\uc73c\ub85c \uba74\uc5ed\uc138\ud3ec\uc758 \uacf5\uaca9\uc744 \ub610 \ub2e4\uc2dc \ud68c\ud53c\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4. \uc6b0\uc120 \uc554\uc138\ud3ec\ub97c \uc2dd\ubcc4\ud558\ub294 \ub370 \ud544\uc694\ud55c \ub2e8\ubc31\uc9c8(MHC I\uc758 \uc77c\ubd80\uc778 b2M)\uc774 \uc81c\uac70, \ubcc0\ud615\ub418\uac70\ub098(\uc774 \uacbd\uc6b0 \uc554\uc138\ud3ec\uc758 \uc2dd\ubcc4\uc774 \uc5b4\ub824\uc6cc\uc9d0), \ub610\ub294 \uadf8 \ud558\uc704\uc758 \uc2e0\ud638\uc804\ub2ec\uc5d0 \uc911\uc694\ud55c \ub2e8\ubc31\uc9c8(JAK)\uc5d0 \ubb38\uc81c\uac00 \uc0dd\uaca8(\uc554\uc138\ud3ec\ub97c \uc2dd\ubcc4\ud588\ub2e4\ub294 \uc2dc\uadf8\ub110\uc744 \ud1b5\ud574 \uba74\uc5ed\uc138\ud3ec \ud65c\uc131\ud654\uac00 \uc774\ub8e8\uc5b4\uc838\uc57c \ud558\ub294\ub370, \uadf8 \uc2e0\ud638\uc804\ub2ec \ud1b5\ub85c\uac00 \ub9c9\ud798) \uba74\uc5ed\uc138\ud3ec\uac00 \uacf5\uaca9 \ubd88\ub2a5 \uc0c1\ud0dc\uc5d0 \ube60\uc9c0\ub294 \uac83\uc774 \ud655\uc778\ub418\uc5c8\ub2e4. \uc0dd\uc874\uc744 \uc704\ud55c \uc554\uc138\ud3ec\uc758 \uc7ac\ubc18\uaca9(\ud1b5\uc0c1\uc801\uc778 \uc758\ubbf8\uc758 \uc57d\ubb3c \ub0b4\uc131)\uc740 \ub05d\ub098\uc9c0 \uc54a\uace0 \uba74\uc5ed\ud56d\uc554\uc81c \uce58\ub8cc\uc5d0\ub3c4 \uacc4\uc18d\ub418\ub294 \uac83\uc774\ub2e4.\uc774\ub7f0 \uae4c\ub2ed\uc5d0 \uc5f0\uad6c\uc790\ub4e4\uc740 \ud55c \uac00\uc9c0 \ubc29\ubc95\uc73c\ub85c \uc554\uc744 \uadf9\ubcf5\ud558\uc9c0 \ubabb\ud558\ub294 \uacbd\uc6b0 \uc5ec\ub7ec \uac00\uc9c0 \uc57d\ubb3c\ub4e4\uc758 \ud611\uacf5\uc73c\ub85c \uc554\uc744 \uc815\ubcf5\ud558\uace0\uc790 \uc218\ub9ce\uc740 \uc870\ud569\uc758 \ud611\uacf5 \ubc29\ubc95\uc5d0 \ub300\ud55c \uc784\uc0c1\uc2e4\ud5d8\uc744 \uc9c4\ud589 \uc911\uc774\ub2e4.<\/p>\n

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\"\uadf8\ub9bc<\/div>\n
\uadf8\ub9bc 5. \uce74\ud2f0(CAR-T) \uc138\ud3ec \uce58\ub8cc\uc758 \uac1c\uc694. \ud658\uc790\uc758 \ud53c\ub85c\ubd80\ud130 \ubd84\ub9ac\ud55c T\uc138\ud3ec\uc5d0 \uc554\uc138\ud3ec\ub97c \uc778\uc2dd\ud558\uace0, T\uc138\ud3ec\uc758 \uba74\uc5ed \ud65c\uc131 \uc2e0\ud638\ub97c \uc8fc\ub3c4\ub85d \uc124\uacc4\ub41c \uc720\uc804\uc790 (CAR, Chimeric antigen receptor)\ub97c \uc8fc\uc785\ud55c\ub2e4. \uc774\ub807\uac8c \uc644\uc131\ub41c \uce74\ud2f0(CAR-T)\uc138\ud3ec\ub4e4\uc744 \uc218\ubc31\ub9cc\uac1c\ub85c \uc99d\uc2dd\uc2dc\ud0a8\ub2e4. \uc774 \uacfc\uc815\uc5d0 2\uc8fc\uc774\uc0c1\uc758 \uc2dc\uac04\uc774 \uc18c\uc694\ub41c\ub2e4. \uc900\ube44\ub41c \uce74\ud2f0\uc138\ud3ec\ub97c \ud658\uc790\uc5d0 \uc8fc\uc785\ud558\uba74, \uce74\ud2f0\uc138\ud3ec\ub4e4\uc740 \uc554\uc138\ud3ec\uc640 \uacb0\ud569\ud558\uc5ec \uc554\uc138\ud3ec\ub97c \uc8fd\uc778\ub2e4. \uadf8\ub7ec\ub098, \ud658\uc790\uc758 \ud53c\ub85c\ubd80\ud130 \ubd84\ub9ac, \uc99d\uc2dd\uae4c\uc9c0\uc758 \uc2dc\uac04\uc744 \ub2e8\ucd95\ud558\uace0, \ube44\uc6a9\ub3c4 \ub2e8\ucd95\ud558\uae30 \uc704\ud55c \uae30\uc131\ud488 \uce74\ud2f0(OTS CAR-T)\ub3c4 \ud65c\ubc1c\ud788 \uc5f0\uad6c \uc911\uc774\ub2e4. \ucd9c\ucc98: National Cancer Institute.<\/div>\n<\/div>\n<\/div>\n

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CAR-T\uc640 \u2018\uc7ac\uc815\uc801 \ub0b4\uc131\u2019<\/b>2017\ub144\uc740 \ud56d\uc554\uce58\ub8cc\uc81c \uac1c\ubc1c\uc5d0\uc11c \uc0c8\ub85c\uc6b4 \uc774\uc815\ud45c\ub97c \uc138\uc6b4 \ud574\uc774\ub2e4. FDA\uc5d0\uc11c \ud5c8\uac00\ub97c \ubc1b\uc740 \uce74\ud2f0(CAR-T, chimeric antigen receptor T cell)\ub77c\ub294 \uc138\ud3ec\uce58\ub8cc\uc81c\uac00 \ud608\uc561\uc554\uc5d0\uc11c \ub192\uc740 \uce58\ub8cc \uc131\uacf5\ub960\uc744 \ubcf4\uc774\uace0 \uc788\uc5b4\uc11c \ud76c\ub9dd\uc744 \uc8fc\uace0 \uc788\uae30 \ub54c\ubb38\uc774\ub2e4.CAR-T\ub294 \ud658\uc790\uc758 \uba74\uc5ed\uc138\ud3ec(T\uc138\ud3ec)\uc5d0 \uc720\uc804\uc801\uc778 \ucc98\ub9ac\ub97c \ud558\uc5ec, \uc554\uc138\ud3ec \ud45c\uba74\uc758 \uc57d\ubb3c \ud45c\uc801\uc744 \uc778\uc2dd\ud568\uacfc \ub3d9\uc2dc\uc5d0 \uacf5\uaca9\ud560 \uc218 \uc788\ub3c4\ub85d T\uc138\ud3ec\ub4e4\uc758 \uacf5\uaca9 \ub2a5\ub825\uc744 \ub354\uc6b1 \ub192\uc778 \uce58\ub8cc\uc81c\uc774\ub2e4. \uc55e\uc5d0\uc11c \uc124\uba85\ud55c \uc554\uc138\ud3ec\uc758 \ub2e4\uc591\ud55c \uba74\uc5ed\ud68c\ud53c \ubc29\ubc95\ub4e4\uc744 \ud55c \ubc88\uc5d0 \uadf9\ubcf5\ud558\uae30 \uc704\ud55c \ubc29\ubc95\uc778 \uac83\uc774\ub2e4.\uc9c0\uae08 \ud5c8\uac00\ub41c CAR-T\uc758 \uacbd\uc6b0\ub97c \uc0b4\ud3b4\ubcf4\uba74, \uc5ec\uc804\ud788 \uc57d\ubb3c \uc791\uc6a9\uacfc \ubd80\uc791\uc6a9\uc758 \uad00\uc810\uc5d0\uc11c\ub3c4 \uac1c\uc120\ud574\uc57c \ud560 \ubb38\uc81c\ub4e4\uc774 \uc874\uc7ac\ud558\uae30\ub294 \ud558\uc9c0\ub9cc, \uac00\uc7a5 \uba3c\uc800 \uac1c\uc120\ud574\uc57c \ud558\ub294 \ubb38\uc81c\ub294 \ube44\uc2fc \uce58\ub8cc\ube44, \uc989, \u201c\uc7ac\uc815\uc801 \ub0b4\uc131(Financial Resistance)\u201d\uc774 \ud06c\ub2e4\ub294 \uc810\uc774\ub2e4. \ud55c\ubc88 \uce58\ub8cc\ub97c \ubc1b\ub294 \ub370 \ub4e4\uc5b4\uac00\ub294 \ube44\uc6a9\uc774 4\uc5b5~5\uc5b5 \uc6d0\uc774\uace0, CAR-T \ud22c\uc5ec \uac00\uaca9\uc5d0\ub2e4 \uce58\ub8cc\uc5d0 \ud544\uc694\ud55c \ube44\uc6a9\uc744 \ud569\ud558\uba74 10\uc5b5 \uc6d0 \ub118\uac8c \ube44\uc6a9\uc774 \ub4e4\uae30 \ub54c\ubb38\uc5d0 \uacbd\uc81c\uc801\uc778 \uc5ec\uc720\uac00 \ucda9\ubd84\ud558\uc9c0 \uc54a\ub2e4\uba74 \uc27d\uac8c \uc0ac\uc6a9\ud558\uae30 \ud798\ub4e0 \uce58\ub8cc\ubc95\uc774\ub2e4. \uc5f0\uad6c\uc790\ub4e4\uc740 \uc774\ub7ec\ud55c \uc0c8\ub85c\uc6b4 \uc7ac\uc815\uc801 \ub0b4\uc131\uc744 \uadf9\ubcf5\ud558\uae30 \uc704\ud55c \ubc29\ubc95\uc5d0 \ub300\ud574\uc11c\ub3c4 \uc5f0\uad6c \uc911\uc774\ub2e4. \ud658\uc790\ub85c\ubd80\ud130 T\uc138\ud3ec\ub97c \ubd84\ub9ac\ud558\uace0 \ucc98\ub9ac\ud558\ub294 \ubc29\uc2dd\uc774 \uc544\ub2c8\uace0, \uc774\ubbf8 \ub9cc\ub4e4\uc5b4 \ub193\uc740 \uae30\uc131\ud488\uc778 CAR-T\ub97c \uc0ac\uc6a9\ud560 \uc218 \uc788\ub294 \ubc29\uc2dd(OTS, Off the Shelf \ubc29\uc2dd)\uc5d0 \ub300\ud55c \uc5f0\uad6c\uac00 \ubc14\ub85c \uadf8\uac83\uc774\ub2e4.\uc704\uc5d0\uc11c \uc0b4\ud3b4\ubcf4\uc558\ub4ef\uc774 \ud56d\uc554 \uce58\ub8cc\uc81c \uac1c\ubc1c\uc744 \uc704\ud574\uc11c\ub294 \uadf9\ubcf5\ud574\uc57c \ud558\ub294 \uc218\ub9ce\uc740 \ub0b4\uc131\/\uc800\ud56d\uc131\ub4e4\uc774 \uc874\uc7ac\ud55c\ub2e4. \uc774\ub7f0 \ub9ce\uc740 \ub0b4\uc131\/\uc800\ud56d\uc131\ub4e4\uc758 \uadfc\uc6d0\uc5d0\ub294 \u201c\ucca0 \uc904\ub2e4\ub9ac\uae30\u201d\uc5d0\uc11c \ubcf4\uc558\ub358 \ubc15\ud14c\ub9ac\uc544\uc758 \u201c\uc0dd\uba85\ub825\u201d\uacfc \ube44\uad50\ud560 \uc218 \uc788\ub294 \uc554\ub4e4\uc758 \u201c\uc0dd\uba85\ub825\u201d\uc774 \uc874\uc7ac\ud55c\ub2e4. \u201c\uc554\uc138\ud3ec\ub3c4 \uc0dd\uba85\uc774\ub2e4\u201d\ub77c\ub294 \ub4dc\ub77c\ub9c8 \ub300\uc0ac\uc640 \ubb34\uad00\ud558\uac8c, \uc554\uc138\ud3ec\uc758 \uc0dd\uba85\u201c\ub825\u201d\ub9cc\uc740 \ubd80\uc815\ud560 \uc218 \uc5c6\ub294 \uc874\uc7ac\uc774\ub2e4. \uadf8\ub9ac\uace0 \uadf8 \uc0dd\uba85\ub825\uc5d0\uc11c\ubd80\ud130 \uae30\uc778\ud558\ub294 \uc5ec\ub7ec \uac00\uc9c0 \ub0b4\uc131\/\uc800\ud56d\uc131\uc758 \uadf9\ubcf5\uc774 \uc554 \uc815\ubcf5\uc744 \uc704\ud55c \uc5f0\uad6c\uc790\ub4e4\uc758 \uad81\uadf9\uc801\uc778 \ubaa9\ud45c\uac00 \ub420 \uac83\uc774\ub2e4.\uadf9\ubcf5\ud574\uc57c \ud560 \ub300\uc0c1\uc774 \ubd84\uba85\ud558\ub2c8 \uc554\uc758 \ub0b4\uc131\/\uc800\ud56d\ub825\uc744 \ubb34\ub825\ud654\uc2dc\ud0a4\uae30 \uc704\ud55c 2\ucc28, 3\ucc28 \uacf5\uaca9\uc744 \uc900\ube44\ud558\ub294 \uc2e0\uc57d\uac1c\ubc1c \uacfc\ud559\uc790\ub4e4\uc758 \uc5f0\uad6c\uc5d0\ub294 \uac00\uc18d\ub3c4\uac00 \ubd99\uace0, \uac00\uae4c\uc6b4 \ubbf8\ub798\uc5d0\ub294 \uc778\ub958\uac00 \uc554\uc5d0 \uc758\ud55c \uc8fd\uc74c\uc758 \uacf5\ud3ec\ub85c\ubd80\ud130 \ud574\ubc29\ub418\uae30\ub97c \uc9c4\uc2ec\uc73c\ub85c \uae30\uc6d0\ud55c\ub2e4.<\/p>\n<\/div>\n

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http:\/\/news.chosun.com\/site\/data\/html_dir\/2018\/10\/03\/2018100302714.html?utm_source=naver&utm_medium=original&utm_campaign=news<\/p>\n

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‘\uc2a4\uc2a4\ub85c \ub0a9\ub4dd\ub420 \ub54c\uae4c\uc9c0’<\/h5>\n

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\ubb3c\ub9ac \uc120\uc0dd\ub2d8 \ubcc4\uba85\uc774 ‘\ub300\ubfcc\ub9ac’\uc600\ub2e4. \uadf8\uac78 \ud6c8\uc721\ubd09 \uc0bc\uc544 \uac00\ub974\ucce4\ub2e4. \uadf8\ub7f0\ub370 \ubb3c\ub9ac \ubc95\uce59\uc744 \uce60\ud310\uc5d0 \uc368\ub193\uace0 \ud0c1\ud0c1 \uce58\uba74\uc11c \ubb34\uc870\uac74 \uc678\uc6b0\ub77c \ud588\ub2e4. \uc65c \uadf8\ub7f0\uc9c0, \uc5b4\ub5bb\uac8c \uac80\uc99d\ub41c \uac74\uc9c0 \ub2f5\ub2f5\ud588\uc9c0\ub9cc \ud604\uc2e4\uc774 \ub530\ub77c\uc8fc\uc9c0 \ubabb\ud588\ub2e4. \uc218\ud559 \ub17c\ub9ac\ub3c4 \uadf8\ub0e5 \uc678\uc6e0\ub2e4. 50\ubd84 \ub3d9\uc548 33\ubb38\uc81c \ud480\ub824\uba74 \uc6d0\ub9ac \ub530\uc708 \uc0dd\uac01\ud560 \uaca8\ub97c\uc774 \uc5c6\uc5c8\ub2e4. \uc77c\ub2e8 \uc815\ub2f5\ubd80\ud130 \uc0dd\uc0b0\ud574\uc57c \ud588\ub2e4. \uc2a4\uc2b9 \ud0d3\uc774 \uc544\ub2c8\ub2e4. \uadf8 \uc2dc\uc808 \uc6b0\ub9ac \uad50\uc721\uc774 \uadf8\ub7ac\ub2e4. \uc810\uc218\ub294 \uc190\uc5d0 \uc950\uc5c8\uc73c\ub098 \ub0a9\ub4dd\uc740 \ubabb \ud588\ub2e4.<\/p>\n

\u25b6 \uc77c\ubcf8 \uad50\uc218\uac00 \ubbf8\uad6d \ud559\uc790\uc640 \ud568\uaed8 \uc62c\ud574 \ub178\ubca8 \uc0dd\ub9ac\uc758\ud559\uc0c1\uc744 \ubc1b\uc558\ub2e4. \uc554\uc744 \uc774\uae30\ub294 \uba74\uc5ed \uba54\ucee4\ub2c8\uc998\uc744 \uaddc\uba85\ud55c \uacf5\ub85c\ub2e4. \uc5ca\uadf8\uc81c \uc218\uc0c1 \ubc1c\ud45c \ub0a0 \uadf8\ub294 “\ub2e4\ub978 \uc0ac\ub78c\uc774 \uc4f4 \uac83\uc744 \ubbff\uc9c0 \uc54a\uace0 \ub0b4 \uba38\ub9ac\ub85c \uc0dd\uac01\ud574\uc11c \ub0a9\ub4dd\ub420 \ub54c\uae4c\uc9c0 \uc5f0\uad6c\ud558\ub294 \uac83\uc774 \ub0b4 \ubc29\uc2dd”\uc774\ub77c\uace0 \ud588\ub2e4. \uc2e0\ubb38\uc740 ‘\uc2a4\uc2a4\ub85c \ub0a9\ub4dd\ub420 \ub54c\uae4c\uc9c0 \uc5b4\ub5a4 \uc5f0\uad6c\ub3c4 \uc548 \ubbff\ub294\ub2e4’\uace0 \uc81c\ubaa9\uc744 \ub2ec\uc558\ub2e4. \uc218\uc0c1\uc790 \uc77c\ud754\uc5ec\uc12f \ud63c\uc870 \ub2e4\uc2a4\ucfe0(\u672c\u5eb6\u4f51) \uad50\uc218\ub294 \uc2e4\uc81c ‘\ub0b4 \uc190\uc73c\ub85c \uac80\uc99d\ud558\uc9c0 \uc54a\uc740 \uc5f0\uad6c\ub294 \ub0b4 \uac83\uc774 \uc544\ub2c8\ub2e4’\ub294 \uc778\uc0dd\uc744 \uc0b4\uc544\uc654\ub2e4.<\/p>\n

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\u25b6 \ud559\uc220\uc9c0 \uc0ac\uc774\uc5b8\uc2a4\ub294 \uc678\ubd80 \uc6d0\uace0\ub97c \ubc1b\uc73c\uba74 \uc77c\ub2e8 \ud3b8\uc9d1\ud68c\uc758\uc5d0\uc11c ‘\uc2ec\uce35 \uc2ec\uc0ac’\ub85c \ub118\uae38\uc9c0\ub97c \uac70\ub978\ub2e4. 80~90%\ub294 \uc774 \ub2e8\uacc4\uc5d0\uc11c \ud0c8\ub77d\ud55c\ub2e4\uace0 \ud55c\ub2e4. \uc804\ubb38\uc704\uc6d0\ub4e4\uc774 \ubb38\ud131\uc744 \ub118\uc740 \uc6d0\uace0\ub97c \ub137\uc73c\ub85c \ub098\ub208\ub2e4. ‘\uadf8\ub300\ub85c \uc2e4\uc74c’ ‘\uc870\uae08 \uc190\ubd04’ ‘\uc911\uac04\ucbe4 \uace0\uce68’ ‘\ud06c\uac8c \uc218\uc815 \uc694\ud568’\uc774\ub2e4. \uc774\uac78 \uac70\uccd0\uc57c \uc2e4\ub9b0\ub2e4. \uadf8\ub7f0\ub370 \ud63c\uc870 \uad50\uc218\ub294 \uc774\ub807\uac8c \ub124\uc774\ucc98\u00b7\uc0ac\uc774\uc5b8\uc2a4\uc5d0 \uc2e4\ub9b0 \uc5f0\uad6c\ub3c4 “90%\ub294 \uac70\uc9d3\ub9d0”\uc774\ub77c\uace0 \ud588\ub2e4. ‘\ub0b4’\uac00 \ub0a9\ub4dd \ubabb \ud588\uace0, \uc2e4\uc81c 10\ub144 \ub4a4 10%\ub9cc \ub0a8\ub294\ub2e4\uace0 \ud588\ub2e4.<\/p>\n

\u25b6 20\uc138\uae30 \ucd08 \ubbf8\uad6d\uc5d0\uc120 \ud3a0\ub77c\uadf8\ub77c\ubcd1\uc73c\ub85c \ud574\ub9c8\ub2e4 10\ub9cc\uba85\uc774 \ubaa9\uc228\uc744 \uc783\uc5c8\ub2e4. \uce58\uc0ac\uc728\uc774 50%\ub97c \ub118\uc5c8\ub2e4. \ub2e4\ub4e4 \uc138\uade0 \uac10\uc5fc\uc774\ub77c \ubbff\uc5c8\uace0, \uade0\uc744 \ubd84\ub9ac\ud574\ub0c8\ub2e4\uace0 \uc8fc\uc7a5\ud558\ub294 \uacfc\ud559\uc790\ub3c4 \ub098\uc654\ub2e4. \uadf8\ub7ec\ub098 \uc804\uc5fc\ubcd1 \ud559\uc790 \uace8\ub4dc\ubc84\uadf8\ub294 \ubbff\uc9c0 \uc54a\uc558\ub2e4. \uadf8\ub294 \ud658\uc790\uc758 \ud53c\u00b7\ubd84\ube44\ubb3c\u00b7\ubc30\uc124\ubb3c\uc744 \uc9c1\uc811 \uc81c \ubab8\uc5d0 \ub123\uc5c8\ub2e4. \uad1c\ucc2e\uc558\ub2e4. \uace8\ub4dc\ubc84\uadf8\ub294 \uc74c\uc2dd\uc744 \ud30c\uace0\ub4e4\uc5c8\ub2e4. \uadf8 \ub355\ubd84\uc5d0 \uacfc\ud559\uc790\ub4e4\uc740 \ub9c8\uce68\ub0b4 \ud544\uc218 \uc601\uc591\uc18c ‘\ub2c8\uc544\uc2e0’\uc744 \ubc1c\uacac\ud588\ub2e4. \ub2c8\uc544\uc2e0\uc744 \ubcf4\uac15\ud55c \ub4a4 \ud3a0\ub77c\uadf8\ub77c\ubcd1\uc774 \uc0ac\ub77c\uc84c\ub2e4.<\/p>\n

\u25b6 \ub374\ub9c8\ud06c \ud559\uc790\uac00 \uae30\uc0dd\ucda9\uc774 \uc554\uc744 \uc77c\uc73c\ud0a8\ub2e4\uace0 \ud558\uace0 1926\ub144 \ub178\ubca8\uc0c1\uae4c\uc9c0 \ubc1b\uc558\ub2e4. \uadf8\ub7ec\ub098 \uc774\ub97c \uc758\uc2ec\ud55c \ub2e4\ub978 \ud559\uc790\ub4e4\uc774 \ub048\uc9c8\uae30\uac8c \uac80\uc99d\uacfc \uc5f0\uad6c\ub97c \uc774\uc5b4\uac04 \ub05d\uc5d0 \ud0c0\ub974\uc5d0\uc11c \ubc1c\uc554\ubb3c\uc9c8 \ubca4\uc870\ud53c\ub80c\uc744 \ucc3e\uc544\ub0c8\ub2e4. \uc81c \uc190\uc73c\ub85c \uac80\uc99d \ubabb \ud55c \uc5b4\ub5a4 \uc5f0\uad6c\ub3c4 \ubbff\uc9c0 \uc54a\uc740 \uacb0\uacfc\ub2e4. \uc57c\uad6c \uac10\ub3c5\ub3c4 \ud22c\uc218\uc5d0\uac8c \ub9d0\ud55c\ub2e4. “\ud648\ub7f0\uc744 \ub9de\ub354\ub77c\ub3c4 \uc2a4\uc2a4\ub85c \ub0a9\ub4dd\ud560 \uc218 \uc788\ub294 \uacf5\uc744 \ub358\uc838\ub77c.” \ub0b4 \uc544\uc774\uc5d0\uac8c \ub9d0\ud558\uace0 \uc2f6\ub2e4. “\uaf34\ucc0c \ud574\ub3c4 \uc88b\ub2e4. \ub124\uac00 \ub0a9\ub4dd\ud560 \uc218 \uc788\ub294 \uacf5\ubd80\ub97c \ud574\ub77c.”<\/p>\n

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\ub6f0\ub294 \uc9c8\ubcd1 \uc704\uc5d0 \ub098\ub294 ‘\uba74\uc5ed’<\/h5>\n

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2018 \ub178\ubca8 \uc0dd\ub9ac\uc758\ud559\uc0c1 \ub2e4\uc2dc\ubcf4\uae30
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\ub9e4\ub144 \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc758 \ubaa9\uc228\uc744 \uc557\uc544\uac00\ub294 \uc554.\u00a0<\/span>\uc758\ud559\uc774 \ubc1c\ub2ec\ud588\ub2e4\uc9c0\ub9cc \uc5ec\uc804\ud788 \uc554\uc740 \ub450\ub824\uc6b4 \uc9c8\ubcd1\uc774\ub2e4. 2018<\/span>\ub144\u00a010<\/span>\uc6d4\u00a01<\/span>\uc77c \uc2a4\uc6e8\ub374 \uc655\ub9bd\uacfc\ud559\uc6d0 \ub178\ubca8\uc0c1\uc704\uc6d0\ud68c\ub294 \uc0dd\ub9ac\uc758\ud559\uc0c1\uc218\uc0c1\uc790\ub85c \uc81c\uc784\uc2a4 \uc568\ub9ac\uc2a8 \ubbf8\uad6d\u00a0MD<\/span>\uc564\ub354\uc2a8\uc554\uc13c\ud130 \uad50\uc218\uc640 \ud63c\uc870 \ub2e4\uc2a4\ucfe0 \uc77c\ubcf8 \uad50\ud1a0\ub300 \uba85\uc608\uad50\uc218\ub97c \uc120\uc815\ud588\ub2e4.\u00a0<\/span>\ub450 \uad50\uc218\ub294 \uc778\uccb4\uc758 \uba74\uc5ed\uc2dc\uc2a4\ud15c\uc744 \uc774\uc6a9\ud574\u00a0\uc0c9\ub2e4\ub978 \uc554\uce58\ub8cc\ubc95<\/u>\uc744 \uac1c\ubc1c\ud55c \uacf5\ub85c\ub97c \uc778\uc815\ubc1b\uc558\ub2e4.\u00a0<\/span>\uc774\ub4e4\uc758 \uc5c5\uc801\uc744 \ud30c\ud5e4\uccd0\ubd24\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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2018 \ub178\ubca8 \uc0dd\ub9ac\uc758\ud559\uc0c1 \uc218\uc0c1\uc790 \uc81c\uc784\uc2a4 \uc568\ub9ac\uc2a8 \uad50\uc218\uc640 \ud63c\uc870 \ub2e4\uc2a4\ucfe0 \uba85\uc608\uad50\uc218(\uc0ac\uc9c4 : \ub178\ubca8\uc0c1\uc704\uc6d0\ud68c)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\uc554 \uce58\ub8cc\uc81c\uc758 3\ub2e8\uacc4 \uc9c4\ud654<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc554 \uce58\ub8cc\uc81c\ub294 \uc138\ub300\ub97c \uac70\ub4ed\ud558\uba70 \uc9c4\ud654\ub97c \uc774\uc5b4\uc654\ub2e4. 1<\/span>\uc138\ub300 \uc554 \uce58\ub8cc\uc81c\ub294 \ub04a\uc784\uc5c6\uc774 \ubd84\uc5f4\ud558\ub294 \uc554 \uc138\ud3ec\uc758 \ud2b9\uc9d5\uc5d0 \ucd08\uc810\uc744 \ub480\ub2e4.\u00a0<\/span>\uc774\uc5d0 \ucc29\uc548\ud574 \uc138\ud3ec \ubd84\uc5f4 \uc790\uccb4\ub97c \uc5b5\uc81c\ud558\uac70\ub098, DNA<\/span>\uc5d0 \uc190\uc0c1\uc744 \uc8fc\ub294 \ud654\ud559\uc801 \ud56d\uc554 \uce58\ub8cc\ubc95\uc774 \uac1c\ubc1c\ub410\ub2e4.\u00a0<\/span>\ud558\uc9c0\ub9cc \uc774\ub7ec\ud55c \uce58\ub8cc\uc81c\ub294\u00a0\uc815\uc0c1 \uc138\ud3ec\uae4c\uc9c0 \uc81c\uac70\ud574 \ubc31\ud608\uad6c \uac10\uc18c,\u00a0<\/span>\ud0c8\ubaa8 \ub4f1 \uc2ec\uac01\ud55c \ubd80\uc791\uc6a9\uc744 \uc218\ubc18\ud55c\ub2e4\ub294 \ubb38\uc81c\uac00 \uc788\uc5c8\ub2e4.<\/span><\/p>\n

\uc774\ud6c4 \uc554\uc138\ud3ec\ub9cc\uc744 \uc120\ud0dd\uc801\uc73c\ub85c \uacf5\uaca9\ud558\ub294 \ud45c\uc801 \ud56d\uc554\uc81c\uac00 \uac1c\ubc1c\ub410\ub2e4. 2<\/span>\uc138\ub300 \uc554 \uce58\ub8cc\uc81c\ub294 \ud56d\uc554 \uce58\ub8cc\ubc95\uc758 \ubd80\uc791\uc6a9\uc744 \ub300\ud3ed \uc904\uc600\uc9c0\ub9cc,\u00a0<\/span>\ub3cc\uc5f0\ubcc0\uc774\uac00 \ud754\ud788 \uc77c\uc5b4\ub098\ub294\u00a0\uc554\uc138\ud3ec\uc758 \ud2b9\uc131\uae4c\uc9c0 \ud3ec\uc6a9\ud558\uc9c0\ub294 \ubabb\ud588\ub2e4.\u00a0<\/span>\ub2e4\uc591\ud55c \ud2b9\uc131\uc744 \uac16\ub294 \uc554\uc138\ud3ec\ub294 \ud45c\uc801 \ud56d\uc554\uc81c\uc5d0 \ub300\ud55c \ub0b4\uc131\uc774 \uc0dd\uae34\ub2e4\ub294 \ud55c\uacc4\uac00 \uc788\uc5c8\ub2e4.<\/span><\/p>\n

\ubc14\ub85c \uc5bc\ub9c8 \uc804\uae4c\uc9c0\ub9cc \ud574\ub3c4 \ud45c\uc801 \ud56d\uc554\uc81c\ub294 \ucd5c\uc2e0 \ud56d\uc554\uce58\ub8cc\uc81c\ub85c \uaf3d\ud614\ub2e4.\u00a0<\/span>\ud558\uc9c0\ub9cc \ucd5c\uadfc\u00a03<\/span>\uc138\ub300 \uc554 \uce58\ub8cc\uc81c\uac00 \ub5a0\uc62c\ub790\ub2e4.\u00a0<\/span>\ubc14\ub85c \uba74\uc5ed\uc744 \ubc14\ub85c \uc7a1\uc544 \uc554\uc744 \uce58\ub8cc\ud558\ub294 \ubc29\uc2dd\uc758\u00a0\u2018<\/u><\/span>\uba74\uc5ed\ud56d\uc554\uc81c<\/u>\u2019<\/u><\/span>\ub2e4.\u00a0<\/span>\uc678\ubd80\uc758 \ubc14\uc774\ub7ec\uc2a4\uac00 \uc720\uc785\ub418\uba74 \uc6b0\ub9ac \ubab8\uc758 \uba74\uc5ed\uc138\ud3ec\uac00 \uc2a4\uc2a4\ub85c \ubc14\uc774\ub7ec\uc2a4\ub97c \uacf5\uaca9\ud558\ub4ef,\u00a0<\/span>\uba74\uc5ed\ud56d\uc554\uc81c\ub294 \uc554\uc138\ud3ec\ub97c \uc77c\uc885\uc758\u00a0\u2018<\/span>\uce68\uc785\uc790\u2019<\/span>\ub85c \uc778\uc2dd\ud558\uac8c \ud55c\ub2e4.\u00a0<\/span>\uc774\ub54c \uc554\uc138\ud3ec\ub97c \uc9c1\uc811 \ud30c\uad34\ud558\ub294 \uac83\uc774 \uc544\ub2c8\ub77c,\u00a0<\/span>\uba74\uc5ed\uc138\ud3ec\uc758 \ub2a5\ub825\uc744 \ub192\uc5ec \uc554\uc138\ud3ec\uac00 \uac00\uc9c4 \ub3c5\ud2b9\ud55c\u00a0<\/u>\u2018<\/u><\/span>\uba74\uc5ed\uc138\ud3ec \ud68c\ud53c \ub2a5\ub825<\/u>\u2019<\/u><\/span>\uc744 \uc5b5\uc81c<\/u>\ud558\ub294 \uac83\uc774\ub2e4.<\/span><\/p>\n

\ubd80\uc791\uc6a9\uacfc \ub0b4\uc131 \ubb38\uc81c\ub97c \ubaa8\ub450 \ud574\uacb0\ud55c \uac83\uc740 \ubb3c\ub860,\u00a0<\/span>\ud22c\uc5ec\ub97c \uc911\ub2e8\ud574\ub3c4\u00a0\uba74\uc5ed\uc138\ud3ec\ub4e4\uc774 \uc774\ub97c \uae30\uc5b5\ud558\uace0 \uacc4\uc18d \uc554\uc138\ud3ec\ub97c \uacf5\uaca9\ud558\uae30 \ub54c\ubb38\uc5d0\u00a0\uc9c0\uc18d\uc801\uc778\u00a0<\/span>\uc554 \uce58\ub8cc \ud6a8\uacfc\ub97c \ubcf4\uc778\ub2e4.<\/span>\u00a0<\/span>\uc778\ub958\uc758 \uc624\ub79c \uc219\uc6d0\uc778\u00a0\u2018<\/span>\uc554 \uc815\ubcf5\u2019<\/span>\uc744 \uac00\ub2a5\ud558\uac8c \ud55c \uc774 \uce58\ub8cc\uc81c \uac1c\ubc1c\uc744 \uc774\ub048 \uc0ac\ub78c\ub4e4\uc774 \ubc14\ub85c \uc62c\ud574 \ub178\ubca8 \uc0dd\ub9ac\uc758\ud559\uc0c1\uc744 \uc218\uc0c1\ud55c \ub450 \uba85\uc758 \uc5f0\uad6c\uc790\ub2e4.<\/span><\/p>\n

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\uc554 \uce58\ub8cc\uc81c\ub294 \uc9c4\ud654\ub97c \uac70\ub4ed\ud574\uc654\ub2e4. (\uc0ac\uc9c4 ; \uc2a4\uc6e8\ub374\uc655\ub9bd\uacfc\ud559\uc6d0 \ub178\ubca8\uc0c1\uc704\uc6d0\ud68c)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\uba74\uc5ed\uae30\ub2a5 \uaed0\ub2e4 \ucf30\ub2e4 \ud558\ub294 \uc2a4\uc704\uce58 ‘\uba74\uc5ed\uad00\ubb38 \uc218\uc6a9\uccb4’ \ubc1c\uacac<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc6b0\ub9ac \ubab8\uc5d0\ub294 \uae30\ubcf8\uc801\uc73c\ub85c \uc9c8\ubcd1\uc744 \uc774\uaca8\ub0bc \uc218 \uc788\ub294 \uba74\uc5ed\uc2dc\uc2a4\ud15c\uc774 \uc788\ub2e4.\u00a0<\/span>\uba74\uc5ed\uc2dc\uc2a4\ud15c\uc758 \ud575\uc2ec\uc740 \uc790\uc2e0(self)<\/span>\uacfc \ube44\uc790\uc2e0(non-self)<\/span>\uc744 \ubd84\uac04\ud560 \uc218 \uc788\ub2e4\ub294 \uac83.\u00a0<\/span>\uc774 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 \uac83\uc774 \ubc14\ub85c\u00a0T<\/u><\/span>\uc138\ud3ec<\/u>\ub2e4. T<\/span>\uc138\ud3ec\ub294 \ud3c9\uc18c\uc5d0 \uce68\uc785\uc790\ub97c \uacf5\uaca9\ud558\ub294\u00a0\u2018<\/span>\ucc29\ud55c \uc138\ud3ec\u2019<\/span>\uc9c0\ub9cc,\u00a0<\/span>\ub54c\ub85c\ub294\u00a0\uacfc\ub3c4\ud55c \uba74\uc5ed \ubc18\uc751\uc73c\ub85c \uc624\ud788\ub824 \uc9c8\ubcd1\uc744 \uc720\ub3c4\ud558\ub294\u00a0\u2018<\/span>\ub098\uc05c \uc138\ud3ec\u2019<\/span>\uac00 \ub418\uae30\ub3c4\u00a0\ud55c\ub2e4.<\/span><\/p>\n

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\ud608\uad6c\uc758 \uc804\uc790\ud604\ubbf8\uacbd \uc0ac\uc9c4 \uc18d T\uc138\ud3ec(\uc624\ub978\ucabd). \uac00\uc2b4\uc0d8(Thymus)\uc5d0\uc11c \uc131\uc219\ub418\uae30 \ub54c\ubb38\uc5d0 \uccab \uc790\ub97c \ub530\uc11c T\uc138\ud3ec\ub77c\ub294 \uc774\ub984\uc774 \ubd99\uc5c8\ub2e4. (\uc0ac\uc9c4 : \uc704\ud0a4\ubc31\uacfc)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\uc568\ub9ac\uc2a8 \uad50\uc218\uc758 \uacf5\ub85c\ub294 \ud55c \ub9c8\ub514\ub85c \uc774\u00a0T<\/span>\uc138\ud3ec\uac00 \ucc29\ud558\uac70\ub098 \ub098\uc058\uac8c \ubcc0\ud558\ub294 \uac83\uc744 \uc870\uc885\ud558\ub294\u00a0\u2018<\/span>\uc2a4\uc704\uce58\u2019<\/span>\ub97c \ubc1c\uacac\ud55c \ub370 \uc788\ub2e4.\u00a0<\/span>\uc758\ud559\uc801\uc73c\ub85c\ub294 \uc774 \uc2a4\uc704\uce58\ub97c\u00a0<\/u>\u2018<\/u><\/span>\uba74\uc5ed\uad00\ubb38 \uc218\uc6a9\uccb4<\/u>(immune checkpoint receptor)\u2019<\/u><\/span>\ub77c\uace0 \ud55c\ub2e4. T<\/span>\uc138\ud3ec\ub97c \uc774\uc6a9\ud55c \uc790\uac00\uba74\uc5ed\uc9c8\ud658 \uce58\ub8cc\ub294 \uc624\ub798\ub3c4\ub85d \uad00\uc2ec \uc5f0\uad6c\ub300\uc0c1\uc774\uc5c8\ub2e4.\u00a0<\/span>\ud558\uc9c0\ub9cc\u00a0T<\/span>\uc138\ud3ec\ub97c \uc554 \uce58\ub8cc\uc5d0 \ud65c\uc6a9\ud558\uc790\ub294 \uc544\uc774\ub514\uc5b4\ub97c \ucc98\uc74c \uc81c\uc2dc\ud55c \uac74 \uc568\ub9ac\uc2a8 \uad50\uc218\ub2e4.\u00a0<\/span>\uc568\ub9ac\uc2a8 \uad50\uc218\ub294\u00a0T<\/span>\uc138\ud3ec\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud558\ub294 \ub2e8\ubc31\uc9c8\uc778\u00a0\u2018CTLA-4\u2019<\/span>\uc758 \uae30\ub2a5\uc744 \uc5b5\uc81c\ud574, T<\/span>\uc138\ud3ec\ub97c \ud65c\uc131\ud654\uc2dc\ud0a4\ub294 \uc57d\ubb3c\uc744 \uac1c\ubc1c\ud588\ub2e4.\u00a0<\/span><\/p>\n

1994<\/span>\ub144\uc5d0\ub294 \uc554\uc744 \uc720\ubc1c\ud55c \uc2e4\ud5d8\uc6a9 \uc950\uc5d0\uac8c\u00a0CTLA-4\u00a0<\/span>\ud56d\uccb4\ub97c \uc8fc\uc785\ud574,\u00a0<\/span>\uc554\uc138\ud3ec\ub97c \uc81c\uac70\ud558\ub294 \uc2e4\ud5d8\uc5d0\ub3c4 \uc131\uacf5\ud588\ub2e4.\u00a0<\/span>\ud558\uc9c0\ub9cc \uc774 \ud56d\uccb4\uac00 \uc778\uac04\uc744 \uc704\ud55c \uc554 \uce58\ub8cc\uc81c\ub85c \uac01\uad11\ubc1b\uc740 \uac83\uc740\u00a02010<\/span>\ub144\uc774\ub098 \ub3fc\uc11c\ub2e4. 2010<\/span>\ub144 \uc568\ub9ac\uc2a8 \uad50\uc218\ub294 \ud53c\ubd80\uc554\uc758 \uc77c\uc885\uc778 \ud751\uc0dd\uc885 \ub9d0\uae30 \ud658\uc790\ub4e4\uc5d0\uac8c\u00a0CTLA-4\u00a0<\/span>\ud56d\uccb4\ub97c \uc8fc\uc785\ud55c \uacb0\uacfc, 20~25%\u00a0\uc644\uce58\uac00 \ub410\ub2e4\ub294 \uc784\uc0c1\uc2e4\ud5d8 \uacb0\uacfc\ub97c \uc5bb\uc5c8\ub2e4.\u00a0\uc774\ud6c4 \uc568\ub9ac\uc2a8 \uad50\uc218\uac00 \uac1c\ubc1c\ud55c \uce58\ub8cc\uc81c\ub294\u00a0<\/span>\uc778\ub958 \ucd5c\ucd08\uc758 \ud56d\uccb4 \uba74\uc5ed \ud56d\uc554\uc81c<\/u><\/span>\ub85c \uc790\ub9ac\ub9e4\uae40\ud588\ub2e4.<\/span><\/p>\n

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\uba74\uc5ed\uae30\ub2a5 \uc5b5\uc81c\ub97c \uc774\uc6a9\ud55c \uba74\uc5ed\ud56d\uc554\uc81c\uc758 \uc791\ub3d9 \uc6d0\ub9ac. (\uc0ac\uc9c4 : \uc704\ud0a4\ubc31\uacfc)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\uba74\uc5ed\ud56d\uc554\uc81c \uc2e4\uc6a9\ud654 \ub2e8\ucd08 \ub9c8\ub828<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\ube44\uc2b7\ud55c \uc2dc\uae30 \uc77c\ubcf8\uc758 \uc5f0\uad6c\uc2e4\uc5d0\uc11c\ub294\u00a0\u2018PD-1\u2019<\/span>\uc774\ub77c\ub294 \ub2e8\ubc31\uc9c8\uc774 \ubc1c\uacac\ub410\ub2e4.\u00a0<\/span>\ud63c\uc870 \uad50\uc218\uac00 \ubc1c\uacac\ud55c\u00a0PD-1\u00a0<\/span>\ub2e8\ubc31\uc9c8 \uc5ed\uc2dc\u00a0T<\/span>\uc138\ud3ec\uc758 \uae30\ub2a5\uc744 \uc5b5\uc81c\ud558\ub294\u00a0\u2018<\/span>\ube0c\ub808\uc774\ud06c\u2019\u00a0<\/span>\uc5ed\ud560\uc744 \ud55c\ub2e4.\u00a0<\/span>\uc774 \ub54c\ubb38\uc5d0\u00a0PD-1<\/span>\uc758 \ud56d\uccb4\ub97c \uc0ac\uc6a9\ud558\uba74\u00a0T<\/u><\/span>\uc138\ud3ec\ub97c \ud65c\uc131\ud654\uc2dc\ucf1c \uc554\uc138\ud3ec\ub97c \uacf5\uaca9<\/u>\ud560 \uc218 \uc788\ub2e4.\u00a0<\/span><\/p>\n

PD-1<\/span>\uacfc\u00a0CTLA-4<\/span>\uc758 \uae30\ub2a5\uc740 \uc720\uc0ac\ud558\uc9c0\ub9cc \uc791\ub3d9 \uc6d0\ub9ac\uc5d0 \uc788\uc5b4\uc11c\ub294 \ucc28\uc774\uac00 \uc788\ub2e4.\u00a0<\/span>\uc8fc\ubcc0 \uba74\uc5ed \uc138\ud3ec\uc5d0 \uc758\ud574 \ud65c\uc131\ud654\ub418\ub294\u00a0CTLA-4<\/span>\uc640 \ub2ec\ub9ac, PD-1<\/span>\uc740 \uc8fc\ub85c \uc554\uc138\ud3ec \ud45c\uba74\uc5d0 \uc874\uc7ac\ud558\ub294 \ud2b9\uc815 \ub2e8\ubc31\uc9c8\uc5d0 \uc758\ud574 \uc5b5\uc81c \uae30\ub2a5\uc774 \ud65c\uc131\ud654\ub3fc\u00a0T<\/span>\uc138\ud3ec\ub97c \ube44\ud65c\uc131\ud654\ud55c\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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CTLA-4\uc640 PD-1 \ub2e8\ubc31\uc9c8\uc758 \uc791\ub3d9 \uc6d0\ub9ac \ucc28\uc774. (\uc0ac\uc9c4: \ub178\ubca8\uc0c1\uc704\uc6d0\ud68c)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\ud63c\uc870 \uad50\uc218\ub294\u00a0PD-1\u00a0<\/span>\ud56d\uccb4\ub97c \ub2e4\uc591\ud55c \uc885\ub958\uc758 \uc554 \ud658\uc790\ub4e4\uc758 \uc784\uc0c1\uce58\ub8cc\uc5d0 \uc801\uc6a9\ud588\ub2e4.<\/span>\u00a0<\/span>\uc774 \uba74\uc5ed\ud56d\uc554\uc81c\ub294\u00a0\u2018<\/span>\uc635\ub514\ubcf4\u2019, \u2018<\/span>\ud0a4\ud2b8\ub8e8\ub2e4\u2019<\/span>\ub77c\ub294 \uc0c1\ud488\uba85\uc73c\ub85c \uc138\uc0c1\uc5d0 \ub098\uc628 \ucd5c\ucd08\uc758\u00a0PD-1<\/span>\uc5b5\uc81c\uc81c\ub294\u00a02014<\/span>\ub144\u00a0<\/span>\ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(FDA)<\/span>\uc758 \uc2b9\uc778\uc744 \ubc1b\uc558\ub2e4.\u00a0<\/span>\ud0a4\ud2b8\ub8e8\ub2e4\ub294 \uc9c0\ubbf8 \uce74\ud130 \ubbf8\uad6d \uc804(<\/span>\u524d)\u00a0<\/span>\ub300\ud1b5\ub839\uc758 \ub1cc\uc885\uc591\uc744 \uc644\uce58\uc2dc\ud0a8 \uc57d\ubb3c\ub85c\ub3c4 \uc720\uba85\ud558\ub2e4.\u00a0<\/span>\uc635\ub514\ubcf4\ub294\u00a02016<\/span>\ub144 \uc2dd\ud488\uc758\uc57d\ud488\uc548\uc804\ucc98\uc758 \ud5c8\uac00\ub97c \ubc1b\uc544 \uad6d\ub0b4\uc5d0 \uc0c1\uc6a9\ud654\ub410\ub2e4.<\/span><\/p>\n

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\uc9c0\ubbf8 \uce74\ud130 \ubbf8\uad6d \uc804 \ub300\ud1b5\ub839\uc758 \ud53c\ubd80\uc554 \ud22c\ubcd1 \uc2dc\uc808 \uae30\uc790\ud68c\uacac \ud604\uc7a5 \ubaa8\uc2b5. (\uc0ac\uc9c4 : CNN Youtube)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\uba74\uc5ed\ud56d\uc554\uc81c\ub97c \ud22c\uc5ec \ubc1b\ub294 \ud658\uc790\ub294 \ub9d0\uae30 \uc554 \ub2e8\uacc4\uc5d0 \uc774\ub978 \uacbd\uc6b0\uac00 \ub9ce\ub2e4.\u00a0<\/span>\uba74\uc5ed\ud56d\uc554\uc81c\ub294 \uc774\ub7f0 \ud658\uc790\ub4e4\uc758 \uc554 \ud06c\uae30\ub97c \uc904\uc774\uace0 \uc544\uc608 \uc5c6\uc560\uae30\uae4c\uc9c0 \ud588\ub2e4.\u00a0<\/span>\ucc98\uc74c\uc5d0\ub294 \uc545\uc131 \ud751\uc0c9\uc885\uc774\ub098 \ud3d0\uc554 \ub4f1\uc5d0 \ud6a8\uacfc\uac00 \ub098\ud0c0\ub0ac\uc9c0\ub9cc \uc810\uc810 \ub300\uc7a5\uc554,\u00a0<\/span>\uac04\uc554,\u00a0<\/span>\uc704\uc554,\u00a0<\/span>\uc2e0\uc7a5\uc554 \ud658\uc790\ub4e4\uc5d0\uac8c\uc11c \uae30\uc801 \uac19\uc740 \uc644\uce58 \uc0ac\uc2e4\uc774 \uc54c\ub824\uc84c\ub2e4.<\/span><\/p>\n

\uadf8\ub807\ub2e4\uace0 \uba74\uc5ed\ud56d\uc554\uc81c\uac00 \ub9cc\ub2a5\uc740 \uc544\ub2c8\ub2e4.\u00a0<\/span>\uc544\uc9c1 \ud55c\uacc4\uac00 \uc788\ub2e4.\u00a0<\/span>\uc554\ud658\uc790\uc758\u00a030%\u00a0<\/span>\uc815\ub3c4\uc5d0\uc11c\ub9cc \uce58\ub8cc \ud6a8\uacfc\ub97c \ubcf4\uc778\ub2e4.\u00a0<\/span>\uc758\ud559\uc790\ub4e4\uc740 \ub098\uba38\uc9c0\u00a070%<\/span>\ub97c \uc704\ud55c \uba74\uc5ed\uce58\ub8cc\ub97c \uc704\ud574 \uc9c0\uae08\ub3c4 \uc5f0\uad6c\uc5d0 \ubab0\uc785 \uc911\uc774\ub2e4.\u00a0<\/span>\uc554\uc740 \uc778\ub958\uac00 \uc815\ubcf5\ud574\uc57c \ud560 \uac00\uc7a5 \uc911\uc694\ud55c \uc758\ud559\uc801 \ub3c4\uc804\uc774\uae30 \ub54c\ubb38\uc774\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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IBS, \uba74\uc5ed\uc138\ud3ec \uac04 ‘\uc0dd\uc874\uacbd\uc7c1’\uc774 \uba74\uc5ed\uacc4 \uade0\ud615 \uc720\uc9c0 \ube44\uacb0\uc784\uc744 \ubc1d\ud600<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\ube44\ub2e8 \uc554 \uce58\ub8cc\ubfd0\ub9cc \uc544\ub2c8\ub77c \uba74\uc5ed\uc740 \uac74\uac15\uc758 \uae30\ubcf8\uc774\uc790 \ud544\uc218\uc801\uc778 \uc870\uac74\uc774 \ub41c\ub2e4.\u00a0<\/span>\uc9c0\uae08\ub3c4 \uc138\uacc4 \uacf3\uacf3\uc758 \uacfc\ud559\uc790\ub4e4\uc774 \uba74\uc5ed\uc744 \uc5f0\uad6c\ud558\ub294 \uc774\uc720\ub2e4.\u00a0<\/span>\uae30\ucd08\uacfc\ud559\uc5f0\uad6c\uc6d0(IBS)\u00a0<\/span>\uba74\uc5ed \ubbf8\uc0dd\ubb3c \uacf5\uc0dd \uc5f0\uad6c\ub2e8 \uc5f0\uad6c\uc9c4\uc740 \uc9c0\ub09c\ud574\u00a08<\/span>\uc6d4 \uba74\uc5ed\uc138\ud3ec\ub4e4\uc774 \uc99d\uc2dd\uc744 \uc704\ud574 \uc11c\ub85c \uacbd\uc7c1\ud558\uba74\uc11c \uc804\uccb4 \uba74\uc5ed\uccb4\uacc4\uc758 \uade0\ud615\uc744 \uc720\uc9c0\ud55c\ub2e4\ub294 \ud765\ubbf8\ub85c\uc6b4 \uc6d0\ub9ac\ub97c \uaddc\uba85\ud558\uae30\ub3c4 \ud588\ub2e4.\u00a0<\/span><\/p>\n

\uc5f0\uad6c\uc9c4\uc740\u00a0\u2018<\/span>\uc120\ucc9c\uc131 \ub9bc\ud504\uc138\ud3ec(ILCs)\u2019<\/span>\uac00 \uba74\uc5ed\uc138\ud3ec \uc870\uc808 \ub2e8\ubc31\uc9c8\uc778\u00a0\u2018<\/span>\uc778\ud130\ub8e8\ud0a8-7(IL-7)\u2019<\/span>\uc744 \ud6a8\uc728\uc801\uc73c\ub85c \uc18c\ube44\ud574 \uccb4\ub0b4 \ub2e4\uc218\ub97c \ucc28\uc9c0\ud558\ub294\u00a0\u2018T<\/span>\uc138\ud3ec\u2019<\/span>\uc758 \uc99d\uc2dd\uc744 \uc870\uc808\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1c\uacac\ud588\ub2e4.\u00a0<\/span>\uc120\ucc9c\uc131 \ub9bc\ud504\uc138\ud3ec\ub294 \uc120\ucc9c\uc801 \uba74\uc5ed\uc744 \ub2f4\ub2f9\ud558\ub294 \uc138\ud3ec\uc774\uba70, T<\/span>\uc138\ud3ec\ub294 \ud6c4\ucc9c\uc801 \uba74\uc5ed\uc5d0\uc11c \uc911\uc2ec \uc5ed\ud560\uc744 \ud55c\ub2e4.\u00a0<\/span>\ub450 \uc138\ud3ec \ubaa8\ub450 \ubc31\ud608\uad6c\uc758\u00a030%<\/span>\ub97c \ucc28\uc9c0\ud558\ub294 \ub9bc\ud504\uad6c\ub85c \ubd84\ub958\ub418\uc9c0\ub9cc,\u00a0<\/span>\uc8fc\ub85c \ud6c4\ucc9c\uc801 \uba74\uc5ed\uc138\ud3ec\uac00 \uc8fc\ub97c \uc774\ub8e8\uba70 \ud2b9\ud788\u00a0T<\/span>\uc138\ud3ec\uac00 \ub9bc\ud504\uad6c\uc758 \uc808\ub300 \ub2e4\uc218\ub97c \ucc28\uc9c0\ud55c\ub2e4.<\/p>\n

\uc5f0\uad6c\uc9c4\uc758 \ubc1c\uacac\uc5d0 \ub530\ub974\uba74 \uc120\ucc9c\uc131 \ub9bc\ud504\uc138\ud3ec\ub294\u00a0T<\/span>\uc138\ud3ec\uc5d0 \ube44\ud574 \ud6e8\uc52c \uc18c\uc218\uc9c0\ub9cc\u00a0T<\/span>\uc138\ud3ec\ubcf4\ub2e4\u00a0IL-7<\/span>\uc744 \ubcf4\ub2e4 \ud6a8\uacfc\uc801\uc73c\ub85c \uc18c\ubaa8\ud560 \uc218 \uc788\ub2e4.\u00a0<\/span>\uace0(<\/span>\u6545)\u00a0<\/span>\ucc30\uc2a4 \uc11c\u00a0IBS\u00a0<\/span>\uba74\uc5ed\ubbf8\uc0dd\ubb3c\uacf5\uc0dd\uc5f0\uad6c\ub2e8 \ub2e8\uc7a5\uc740\u00a0“\uc120\ucc9c\uc131 \ub9bc\ud504\uc138\ud3ec\uc758 \uc774\ub7ec\ud55c \uc0dd\uc874\ubc95 \ub355\ubd84\uc5d0 \uba74\uc5ed\uccb4\uacc4\ub294 \ub2e4\uc591\uc131\uc744 \uc720\uc9c0\ud55c\ub2e4”\uba70\u00a0“\uc774 \uc5f0\uad6c\ub294\u00a0IL-7<\/span>\uc744 \ud65c\uc6a9\ud55c \uba74\uc5ed \uce58\ub8cc\ubc95 \uc99d\uc9c4\uc5d0 \uae30\uc5ec\ud560 \uac83”\uc774\ub77c\uace0 \uc124\uba85\ud588\ub2e4.<\/span><\/p>\n

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\uccb4\ub0b4 \uc120\ucc9c\uc131 \ub9bc\ud504 \uc138\ud3ec(\ud68c\uc0c9)\uc640 T\uc138\ud3ec(\ubbf8\uc0c9)\uac00 \uac00\uc9c4 IL-7 \uc218\uc6a9\uccb4(\uc7a0\uc790\ub9ac\uccb4)\ub294 \uadf8\ub4e4\uc758 \uc0dd\uc874\uacfc \uccb4\ub0b4 \uc720\uc9c0\uc5d0 \ud544\uc694\ud55c \uc870\uc808\uc778\uc790\ub2e4. \uc120\ucc9c\uc120 \ub9bc\ud504 \uc138\ud3ec\ub294 IL-7\uacfc\uc758 \uacb0\ud569\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 IL-7 \uc218\uc6a9\uccb4\uc758 \ubc1c\ud604(\uc7a0\uc790\ub9ac\ucc44\uac00 \ub9ce\uc74c)\uc774 \ub192\uac8c \uc720\uc9c0\ub418\uc5b4 IL-7\uc5d0 \ub300\ud574 \uacbd\uc7c1 \uc6b0\uc704\ub97c \uac16\uac8c \ud55c\ub2e4. (\uc0ac\uc9c4 \ubc0f \ub0b4\uc6a9 : IBS)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\uc720\uc0b0\uade0\uc81c \ud504\ub85c\ubc14\uc774\uc624\ud2f1\uc2a4, \ubaa9\uc18d ‘\uba74\uc5ed \uc120\uc0dd\ub2d8’ \uc5ed\ud560<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc9c0\ub09c\u00a010<\/span>\uc6d4\u00a020<\/span>\uc77c,\u00a0<\/span>\uc784\uc2e0\ud601\u00a0IBS\u00a0<\/span>\uba74\uc5ed \ubbf8\uc0dd\ubb3c \uacf5\uc0dd \uc5f0\uad6c\ub2e8 \uad50\uc218\ud300\uc740 \uad6d\uc81c\ud559\uc220\uc9c0\u00a0\u2018<\/span>\uc0ac\uc774\uc5b8\uc2a4 \uc774\ubba4\ub180\ub85c\uc9c0\u2019<\/span>\uc5d0 \ud504\ub85c\ubc14\uc774\uc624\ud2f1\uc2a4\uac00 \uc6b0\ub9ac \ubab8\uc18d \uba74\uc5ed\uccb4\uacc4\ub97c \uad50\uc721\uc2dc\ud0a4\ub294 ‘\uba74\uc5ed \uc120\uc0dd\ub2d8’\uc758 \uc5ed\ud560\uc744 \ud560 \ubfd0\ub9cc \uc544\ub2c8\ub77c,\u00a0<\/span>\uba74\uc5ed\uacfc \uad00\ub828\ub41c \uc9c8\ud658\uc744 \uce58\ub8cc\ud558\ub294 \uc2e0\uc57d \ud6c4\ubcf4\ubb3c\uc9c8\ub85c\ub3c4 \uc791\uc6a9\ud560 \uc218 \uc788\ub2e4\ub294 \uc5f0\uad6c\uacb0\uacfc\ub97c \ubc1c\ud45c\ud588\ub2e4.\u00a0<\/span>\ub2e8\uc21c\ud788 \uac74\uac15\uc2dd\ud488\uc758 \ubc94\uc8fc\uc5d0 \ud3ec\ud568\ub418\ub358 \uc720\uc0b0\uade0\uc81c \ud504\ub85c\ubc14\uc774\uc624\ud2f1\uc2a4\ub97c \uc774\uc6a9\ud574\u00a0\uc5fc\uc99d\uc131 \uc9c8\ud658\uc774\ub098 \uc544\ud1a0\ud53c \uac19\uc740 \uc54c\ub808\ub974\uae30 \uc9c8\ud658\uc744 \uce58\ub8cc\ud560 \uc218 \uc788\ub294\u00a0\uba74\uc5ed\uce58\ub8cc\uc81c \uac1c\ubc1c \uac00\ub2a5\uc131<\/u>\uc744 \uc5f0 \uac83\uc774\ub2e4.\u00a0<\/span><\/p>\n

\uc5f0\uad6c\uc9c4\uc740\u00a0\u2018<\/span>\ubaa8\uc720 \uc218\uc720\ub97c \ud1b5\ud574 \uc720\uc775\ud55c \uc7a5\ub0b4 \ubbf8\uc0dd\ubb3c\uc774 \ub9ce\uc740 \uc5b4\ub9b0\uc774\uac00 \uc544\ud1a0\ud53c \ud53c\ubd80\uc5fc \uac19\uc740 \uba74\uc5ed \uacfc\ubbfc \uc9c8\ud658\uc5d0 \ub35c \uac78\ub9b0\ub2e4‘<\/span>\ub294 \uc0ac\uc2e4\uc5d0 \ucc29\uc548,\u00a0<\/span>\ud504\ub85c\ubc14\uc774\uc624\ud2f1\uc2a4\uc640 \uba74\uc5ed\uc9c8\ud658 \uce58\ub8cc\uc81c \uac04 \uc5f0\uacb0\uace0\ub9ac\ub97c \ucc3e\uc558\ub2e4.\u00a0<\/span>\uc790\uccb4 \uac1c\ubc1c\ud55c \ubd84\uc11d \uc2dc\uc2a4\ud15c\uc744 \ubc14\ud0d5\uc73c\ub85c \ud504\ub85c\ubc14\uc774\uc624\ud2f1\uc2a4 \uc911 \uba74\uc5ed\uc138\ud3ec\uc778\u00a0T<\/span>\uc138\ud3ec\ub97c \ud65c\uc131\ud654\uc2dc\ud0ac \uc218 \uc788\ub294 \uade0\u00a0200<\/span>\uc5ec \uc885\uc744 \uace8\ub77c\ub0c8\ub2e4.\u00a0<\/span>\uc774\uc911 \uac74\uac15\ud55c \uc5b4\ub9b0\uc774\uc758 \ubd84\ubcc0\uc5d0\uc11c \uac00\uc7a5 \ub9ce\uc774 \ubc1c\uacac\ub418\ub294 \ube44\ud53c\ub354\uc2a4\u00a0PRI1\u00a0<\/span>\uade0\uc744 \ucd5c\uc885 \ud6c4\ubcf4\ubb3c\uc9c8\ub85c \uc120\uc815\ud574 \ubd84\ub9ac\ud588\ub2e4.<\/span><\/p>\n

\uc774\ud6c4 \uc7a5\uc5d0 \uc5fc\uc99d\uc744 \uc553\ub294 \uc950\uc5d0 \ube44\ud53c\ub354\uc2a4\u00a0PRI1\u00a0<\/span>\uade0\uc744 \ud22c\uc5ec\ud588\ub354\ub2c8\u00a03<\/span>\uc8fc \ub9cc\uc5d0 \uc18c\uc7a5\uacfc \ub300\uc7a5\uc5d0 \uba74\uc5ed\uc870\uc808\u00a0T<\/span>\uc138\ud3ec\uac00 \ud06c\uac8c \uc99d\uc2dd\ud55c \uac83\uc744 \ud655\uc778\ud588\ub2e4.\u00a0<\/span>\uc7a5 \ud45c\uba74\uc758 \uc5fc\uc99d\uc740 \uade0\uc744 \ud22c\uc5ec\ud558\uc9c0 \uc54a\uc740 \uc950\uc5d0 \ube44\ud574 \ub208\uc5d0 \ub744\uac8c \uc904\uc5c8\ub2e4.<\/span><\/p>\n

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\"\"<\/a><\/p>\n

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PRI1\uade0\uc744 \uc7a5 \uc9c8\ud658 \uc5fc\uc99d\uc744 \uac00\uc9c4 \uc2e4\ud5d8\uc950\uc5d0 \ud22c\uc5ec\ud558\uc790 3\uc8fc \ud6c4 \uc5fc\uc99d\uc774 \uc904\uc5b4\ub4e4\uc5c8\ub2e4.(\uc704) \ub610\ud55c, \ube44\ud53c\ub354\uc2a4 PRI1\uade0\uc5d0\uc11c \uc21c\uc218 \ubd84\ub9ac\ud55c \uc138\ud3ec \ud45c\uba74 \ub2e4\ub2f9\uccb4(CSGG)\ub9cc \uc2e4\ud5d8\uc950\uc5d0 \ud22c\uc5ec\ud574\ub3c4 \uc5fc\uc99d\uc131 \uc7a5 \uc9c8\ud658\uc758 \uc5b5\uc81c \ud6a8\ub2a5\uc744 \ud655\uc778\ud560 \uc218 \uc788\uc5c8\ub2e4. (\uc544\ub798)(\uc0ac\uc9c4 \ubc0f \ub0b4\uc6a9 : IBS)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\ub098\uc544\uac00 \uc5f0\uad6c\uc9c4\uc740 \ube44\ud53c\ub354\uc2a4\u00a0PRI1\u00a0<\/span>\uade0\uc758 \uc138\ud3ec\ud45c\uba74\ub2e4\ub2f9\uccb4(CSGG)<\/span>\uac00 \uba74\uc5ed\uc744 \ud65c\uc131\ud654\ud558\ub294 \ubb3c\uc9c8\uc774\ub77c\ub294 \uc0ac\uc2e4\ub3c4 \uc0c8\ub86d\uac8c \uaddc\uba85\ud588\ub2e4.\u00a0<\/span>\uc774\ub294\u00a0\u2018<\/span>\ud504\ub85c\ubc14\uc774\uc624\ud2f1\uc2a4\uac00 \uc0b4\uc544 \uc788\uc5b4\uc57c\ub9cc \ud6a8\ub2a5\uc744 \ubc1c\ud718\ud560 \uac83\u2019<\/span>\uc774\ub77c\ub358 \uae30\uc874 \uc0c1\uc2dd\uc744 \ub4a4\uc9d1\uc740 \uacb0\uacfc\ub2e4.\u00a0<\/span>\ud2b9\uc815 \ud504\ub85c\ubc14\uc774\uc624\ud2f1\uc2a4\ub9cc \uc720\uc775\ud55c \ud65c\uc131\uc744 \uc9c0\ub2c8\ub294 \uc774\uc720\uc5d0 \ub300\ud574 \uacfc\ud559\uc801 \uadfc\uac70\ub97c \uc81c\uc2dc\ud588\ub2e4\ub294 \uce21\uba74\uc5d0\uc11c\ub3c4 \uc8fc\ubaa9\ud560 \ub9cc\ud558\ub2e4.\u00a0<\/span><\/p>\n

\uc5f0\uad6c\uc9c4\uc740 \uc624\ub298\ub3c4 \uc9c8\ubcd1\uc758 \uc608\ubc29 \ucc28\uc6d0\ubfd0 \uc544\ub2c8\ub77c \uc774\ubbf8 \uac78\ub9b0 \uba74\uc5ed\uc9c8\ud658\uc758 \uc9c4\ud589\uc744 \ub2a6\ucd9c \uc218 \uc788\ub294 \uce58\ub8cc\uc81c\ub97c \uace0\ubbfc\ud558\uace0 \uc788\ub2e4.\u00a0<\/span>\uc624\ub85c\uc9c0 \uba74\uc5ed\uc9c8\ud658 \uce58\ub8cc \uc2e0\ub150 \ud558\ub098\ub85c \uadf8 \uae38\uc744 \uac77\uace0 \uc788\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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 <\/p>\n

\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~<\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

    \uba74\uc5ed\ud56d\uc554\uc81c \uc5f0\uad6c\ubd84\uc57c \uc5f0\uad6c\uc790\uc778 \uc81c\uc784\uc2a4 \uc568\ub9ac\uc2a8\uacfc \ud63c\uc870 \ub2e4\uc2a4\ucfe0\uac00 2018\ub144 \ub178\ubca8\uc0dd\ub9ac\uc758\ud559\uc0c1\uc744 \uc218\uc0c1\ud588\uad70\uc694^^ (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~)     James Allison and Tasuku Honjo pioneered treatments that(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[32,33,29,30,47],"tags":[],"class_list":["post-1960","post","type-post","status-publish","format-standard","hentry","category-essays-on-science","category-do-biology","category-lets-do-science","category-recent-science-news","category-47"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":2805,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2805","url_meta":{"origin":1960,"position":0},"title":"From poor prognosis to promising treatment","author":"biochemistry","date":"March 9, 2019","format":false,"excerpt":"\u00a0 \u00a0 Over the past several decades, evidence has accumulated that stromal cells\u2014the nonmutated cells that surround malignant cancer cells\u2014are not mere bystanders in tumorigenesis. 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We now know that metastatic cancer cells must reprogram the tumor stroma, or tumor microenvironment (TME),\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2538,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2538","url_meta":{"origin":1960,"position":1},"title":"\uc6b0\uc5f0\ud55c \ubc1c\uacac \uc774\uc57c\uae30 – \uc548\ud14c\ub098 \uace0\uce58\ub824\ub2e4 ‘\ud0dc\ucd08\uc758 \ube5b’ \ucc3e\uc544.. \uc74c\uadf9\uc120 \uc2e4\ud5d8\uc911 ‘X\ub808\uc774’ \ubc1c\uacac\ub3c4","author":"biochemistry","date":"January 18, 2019","format":false,"excerpt":"\u00a0 \u00a0 \uc6b0\uc5f0\u00b7\uc0ac\uace0\uac00 \ub0b3\uc740 \uc704\ub300\ud55c \uacfc\ud559 \uc774\uc57c\uae30 \u00a0 \u00a0 \u00a0 \u00a0 '\uc6b0\uc5f0'\uc774\ub098 '\uc0ac\uace0'\ub294 \uacfc\ud559\uacfc \uc5b4\uc6b8\ub9ac\uc9c0 \uc54a\ub294 \ub2e8\uc5b4\ub2e4. \uacfc\ud559\uc790\ub4e4\uc740 \ub300\ubd80\ubd84 \ud558\uace0 \uc2f6\uc740 \uc5f0\uad6c\uc8fc\uc81c\ub97c \uba85\ud655\ud558\uac8c \uc815\ud55c \ub4a4 \ubaa9\ud45c\ub97c \ud5a5\ud574 \uac04\ub2e4. \uc624\ub79c \uc138\uc6d4 \uc9c0\uc2dd\uc774 \ucd95\uc801\ub418\uace0, \uc5b4\ub5a4 \ubc29\ud5a5\uc774 \uc633\uace0 \uc5b4\ub5a4 \ubc29\ud5a5\uc740 \ud2c0\ub838\ub294\uc9c0 \uc2dd\ubcc4\ud558\ub294 \ub178\ud558\uc6b0\ub97c \uc313\uc544\uac04\ub2e4. \uadf8\ub798\uc11c \uacfc\ud559\uc744 '\uacbd\ud5d8\uc758 \uc0b0\ubb3c'\uc774\ub77c\uace0 \ud55c\ub2e4. \ud558\uc9c0\ub9cc \uc544\uc774\ub7ec\ub2c8\ud558\uac8c\ub3c4 \uc704\ub300\ud55c \uacfc\ud559\uc801\u2026","rel":"","context":"In "'01. \uc6b0\uc8fc: \ubbf8\uc2dc\uc5d0\uc11c \uac70\uc2dc\uae4c\uc9c0'\uc640 '02. \uc2dc\uac04\uacfc \uacf5\uac04' \uad00\ub828"","block_context":{"text":"'01. \uc6b0\uc8fc: \ubbf8\uc2dc\uc5d0\uc11c \uac70\uc2dc\uae4c\uc9c0'\uc640 '02. \uc2dc\uac04\uacfc \uacf5\uac04' \uad00\ub828","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=39"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/t1.daumcdn.net\/news\/201209\/04\/seoul\/20120904023137427.jpg?resize=350%2C200&ssl=1","width":350,"height":200},"classes":[]},{"id":2559,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2559","url_meta":{"origin":1960,"position":2},"title":"\ucd08\ub2a5\ub825\uc790\uc5d0 \uc18d\uc740 \uacfc\ud559\uc790, \uacfc\ud559\uc790\ub97c \uc18d\uc778 \ub9c8\uc220\uc0ac","author":"biochemistry","date":"January 24, 2019","format":false,"excerpt":"\u00a0 \u00a0 \uc0ac\ub78c\uc744 \uc18d\uc774\ub294 \ub2a5\ub825\uc740 \ubb34\uad81\ubb34\uc9c4\ud558\ub2e4 \ub9c8\uc220\uc0ac\uc774\uc790 \ucd08\ub2a5\ub825\uc790 \uc0ac\ub0e5\uafbc, \uc81c\uc784\uc2a4 \ub79c\ub514 \u00a0 \u00a0 \ub9c8\uc220\uc0ac\uc774\uc790\u00a0\uacfc\ud559\uc801\u00a0\ud68c\uc758\uc8fc\uc758\uc790\uc778\u00a0\uc81c\uc784\uc2a4\u00a0\ub79c\ub514\ub294\u00a0\uc8fc\ub85c\u00a0\ud604\ub300\uc758\u00a0\ucd08\uc790\uc5f0\uc801\uc778\u00a0\ub2a5\ub825\uc744\u00a0\ube44\ud310\ud558\ub294\u00a0\u2018\ucd08\ub2a5\ub825\uc790\u00a0\uc0ac\ub0e5\uafbc\u2019\uc774\uc5d0\uc694.\u00a01972\ub144\uc5d0\u00a0\ub2f9\uc2dc\u00a0\uc21f\uac00\ub77d\u00a0\uad6c\ubd80\ub9ac\uae30\ub85c\u00a0\uad49\uc7a5\ud55c\u00a0\uc778\uae30\ub97c\u00a0\ub04c\uc5c8\ub358\u00a0\ucd08\ub2a5\ub825\uc790\u00a0\uc720\ub9ac\u00a0\uac94\ub7ec\uac00\u00a0\uc0ac\uae30\uafbc\uc774\ub77c\ub294\u00a0\uac78\u00a0\ud3ed\ub85c\ud558\uba74\uc11c\u00a0\uc720\uba85\ud574\uc84c\uc9c0\uc694.\u00a0\uc720\ub9ac\u00a0\uac94\ub7ec\ub294\u00a0\ubcf8\uc778\uc758\u00a0\ub9d0\uc744\u00a0\ub530\ub974\uba74\u00a0\u2018\uc5fc\ub825\u2019\uc744\u00a0\uc774\uc6a9\ud574\u00a0\uae08\uc18d\uc744\u00a0\uad6c\ubd80\ub9b4\u00a0\uc218\u00a0\uc788\uc5c8\uc5b4\uc694.\u00a0\ud558\uc9c0\ub9cc\u00a0\ub79c\ub514\ub294\u00a0\uc720\ub9ac\u00a0\uac94\ub7ec\uc758\u00a0\ucd08\ub2a5\ub825\uc774\u00a0\uadf8\uc800\u00a0\uc18d\uc784\uc218\uc774\uba70\u00a0\uadf8\ub807\uac8c\u00a0\uad50\ubb18\ud558\uc9c0\ub3c4\u00a0\uc54a\ub2e4\uace0\u00a0\uc8fc\uc7a5\ud588\uc5b4\uc694.\u00a0\uadf8\ub9ac\uace0\u00a0\ub9c8\uc220\uc744\u00a0\uc774\uc6a9\ud574\u00a0\uc9c1\uc811\u00a0\uc21f\uac00\ub77d\u00a0\uad6c\ubd80\ub9ac\uae30\uc758\u00a0\ube44\ubc00\uc744\u00a0\uc5ec\ub7ec\u00a0\ubc88\u00a0\ubc1d\ud600\ub0c8\uc9c0\uc694. \u00a0 \u00a0 \ud55c \uc2dc\ub300\ub97c \ud48d\ubbf8\ud588\ub358 '\ucd08\ub2a5\ub825\uc790' \uc720\ub9ac \uac94\ub7ec. \uc9c0\uae08\ub3c4 \uadf8\uc758 \uc774\ub984\uc740 '\ucd08\ub2a5\ub825'\uc758 \ub300\uba85\uc0ac\ub85c \uc4f0\uc774\uace0 \uc788\ub2e4. \u00a0 \u00a0 \ub9c8\uc220\ub85c \uacfc\ud559\uc790\ub97c \uc18d\uc774\ub2e4? 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