{"id":1876,"date":"2018-09-26T11:48:12","date_gmt":"2018-09-26T02:48:12","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=1876"},"modified":"2019-10-14T14:51:29","modified_gmt":"2019-10-14T05:51:29","slug":"%ea%bc%ac%eb%a6%ac%ea%b0%80-%ea%b8%b8%eb%a9%b4-%eb%b0%9f%ed%9e%88%eb%8a%94-%eb%b2%95-mrna%ec%9d%98-%ea%bc%ac%eb%a6%ac%eb%a5%bc-%ec%b0%be%ec%95%84%ec%84%9c","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1876","title":{"rendered":"\uaf2c\ub9ac\uac00 \uae38\uba74 \ubc1f\ud788\ub294 \ubc95, mRNA\uc758 \uaf2c\ub9ac\ub97c \ucc3e\uc544\uc11c"},"content":{"rendered":"

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mRNA \uaf2c\ub9ac\uc5d0 \uad00\ud55c \uc11c\uc6b8\ub300 \uae40\ube5b\ub0b4\ub9ac \uad50\uc218\ub2d8\uc758 \ucd5c\uadfc \ub17c\ubb38 \uc124\uba85\uc785\ub2c8\ub2e4~<\/p>\n

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\ub2e8\ubc31\uc9c8\uacfc \uc138\ud3ec\uc758 \uc6b4\uba85 \uacb0\uc815\uc790, \uc804\ub839RNA(mRNA)<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uace0\ud608\uc555 \ud658\uc790\uc640 \ub9c8\ub77c\ud1a4 \uc120\uc218\uc758 \uacf5\ud1b5\uc810\uc774 \uc788\ub2e4<\/i>.\u00a0<\/i><\/span>\uc2ec\uc7a5\uc774 \uc77c\ubc18 \uc0ac\ub78c\ubcf4\ub2e4 \ud06c\ub2e4\ub294 \uac83<\/i>.\u00a0<\/i><\/span>\ub450 \uc0ac\ub78c \ubaa8\ub450 \ucee4\ub2e4\ub780 \uc2ec\uc7a5\uc744 \uac00\uc84c\ub2e4\ub294 \uc870\uac74\uc740 \uac19\ub2e4<\/i>.\u00a0<\/i><\/span>\ud558\uc9c0\ub9cc \uac74\uac15 \uce21\uba74\uc5d0\uc11c \uacb0\uacfc\ub294 \ub2e4\ub974\ub2e4<\/i>.\u00a0<\/i><\/span>\uace0\ud608\uc555 \ud658\uc790\ub294 \uc2ec\uc7a5\ub9c8\ube44\ub97c \uc553\uc744 \uac00\ub2a5\uc131\uc774 \ud06c\uc9c0\ub9cc \ub9c8\ub77c\ud1a4 \uc120\uc218\ub294 \ub300\uccb4\uc801\uc73c\ub85c \uac74\uac15\ud55c \uc0b6\uc744 \uc0b0\ub2e4<\/i>.\u00a0<\/i><\/span>\uc774\uc720\uac00 \ubb34\uc5c7\uc77c\uae4c<\/i>.\u00a0<\/i><\/span>\uc2ec\uc7a5\ub9cc \ub4e4\uc5ec\ub2e4\ubd10\uc11c\ub294 \uc815\ud655\ud558\uac8c \ub2f5\ud558\uae30 \uc5b4\ub835\ub2e4<\/i>.\u00a0<\/i><\/span>\uc720\uc804\uc815\ubcf4\uac00 \ub2f5\uc744 \uc950\uace0 \uc788\uae30 \ub54c\ubb38\uc774\ub2e4<\/i>.\u00a0<\/i><\/span>\uc0dd\uba85\ud604\uc0c1\uc5d0\uc11c\u00a0<\/i>DNA<\/i><\/span>\ub294 \uc720\uc804\uc815\ubcf4\ub97c \uac16\uace0 \uc788\ub294 \ucc3d\uace0\uc640 \uac19\ub2e4<\/i>. DNA<\/i><\/span>\ub294 \uc720\uc804\uc815\ubcf4\ub97c \ubc14\ud0d5\uc73c\ub85c \uac01 \uc138\ud3ec\uac00 \uae30\ub2a5\ud558\uace0 \ud65c\uc131\ud654\ub420 \uc218 \uc788\ub3c4\ub85d \ub2e8\ubc31\uc9c8\uc744 \ud569\uc131\ud55c\ub2e4<\/i>.\u00a0<\/i><\/span>\uc774 \uacfc\uc815\uc5d0\uc11c \ub4f1\uc7a5\ud558\ub294 \uac83\uc774 \uba54\uc2e0\uc800<\/i>, \u2018<\/i><\/span>\uc804\ub839<\/i>RNA(messengerRNA,\u00a0<\/i><\/span>\uc774\ud558\u00a0<\/i>mRNA)\u2019<\/i><\/span>\ub2e4<\/i>. mRNA<\/i><\/span>\ub294\u00a0<\/i>DNA<\/i><\/span>\uc5d0 \ub2f4\uae34 \uc720\uc804\uc815\ubcf4\ub97c \ubcf5\uc0ac\ud574 \ub2e8\ubc31\uc9c8\ub85c \uc804\ub2ec\ud558\ub294 \ud575\uc2ec \ub9e4\uac1c\uccb4\ub2e4<\/i>.<\/i><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\ub2e8\ubc31\uc9c8 \uc0dd\uc131 \uacfc\uc815\uc744 \uc790\uc138\ud788 \uc0b4\ud3b4\ubcf4\uc790.\u00a0<\/span>\uba3c\uc800 \uc138\ud3ec \ud575 \uc548\uc5d0 \ud2b9\uc815 \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4dc\ub294\u00a0DNA<\/span>\uc758 \uc124\uacc4\ub3c4(<\/span>\uc720\uc804\uc815\ubcf4)<\/span>\uac00\u00a0mRNA<\/span>\ub85c \uc62e\uaca8\uc9c4\ub2e4.\u00a0<\/span>\uc774\ub97c \uc804\uc0ac(Transcription)\u00a0<\/span>\uacfc\uc815\uc774\ub77c \ud55c\ub2e4.\u00a0<\/span>\uc804\uc0ac\ub97c \uac70\uce5c\u00a0mRNA<\/span>\ub294 \uc720\uc804\uc815\ubcf4\ub97c \uadf8\ub300\ub85c \ubcf5\uc0ac\ud574 \ud575 \ubc14\uae65 \uc138\ud3ec\uc9c8\uc5d0 \uc788\ub294 \ub9ac\ubcf4\uc19c\uc73c\ub85c \uc3d9 \ub4e4\uc5b4\uac04\ub2e4.\u00a0<\/span>\ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4e4\uc5b4\ub0b4\ub294 \ud569\uc131\uacf5\uc7a5 \ub9ac\ubcf4\uc19c\uc5d0\u00a0mRNA<\/span>\uac00 \uc548\ucc29\ud574 \uc788\uc73c\uba74 \uc6b4\ubc18\ucc45\uc774 \ub3c4\ucc29\ud55c\ub2e4.\u00a0<\/span>\uc6b4\ubc18RNA(transferRNA, tRAN)<\/span>\uac00\u00a0mRNA<\/span>\uc758 \uc5fc\uae30\uc11c\uc5f4\uc5d0 \ub9de\ub294 \uc544\ubbf8\ub178\uc0b0\uc744 \uac00\uc838\uc640 \uc774\uc5b4 \ubd99\uc774\uba74 \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4dc\ub294 \uc804 \uacfc\uc815\uc774 \ub05d\ub09c\ub2e4.\u00a0<\/span>\uad6c\uc2ac\uc744 \uc5ee\uc5b4 \ubaa9\uac78\uc774\ub97c \ub9cc\ub4e4 \ub4ef \ub9ac\ubcf4\uc19c\uc5d0\uc11c\u00a0mRNA<\/span>\uc758 \uc5fc\uae30\uc11c\uc5f4\ub300\ub85c \uc544\ubbf8\ub178\uc0b0\uc744 \uaff0\uc5b4 \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4dc\ub294 \uc148\uc774\ub2e4.\u00a0<\/span>\uc815\ub9ac\ud558\uba74 \uc804\uc0ac\uc640 \ubc88\uc5ed \uacfc\uc815\uc744 \uac70\uccd0 \uc0dd\uba85\ud65c\ub3d9\uc5d0 \ud544\uc694\ud55c \ubcf5\uc7a1\ud55c \ub2e8\ubc31\uc9c8\uc774 \uc0dd\uc131\ub418\ub294 \uac83\uc774\ub2e4.\u00a0<\/span>
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\ub2e8\ubc31\uc9c8 \uc0dd\uc0b0\uacfc\uc815\uc744 \ubcf4\uc5ec\uc8fc\ub294 \ubaa8\uc2dd\ub3c4. \uc720\uc804\uc815\ubcf4\ub97c \ub2f4\uc740 DNA\uc5d0 \ub530\ub77c \uc804\uc0ac \uacfc\uc815\uc744 \uac70\uce58\uba74 \ub9ac\ubcf4\uc19c, mRNA, \uc6b4\ubc18RNA, \uc544\ubbf8\ub178\uc0b0\uc774 \ucd1d\ub3d9\uc6d0\ub418\uc5b4\uc57c \ub2e8\ubc31\uc9c8\uc774 \ub9cc\ub4e4\uc5b4\uc9c4\ub2e4. (\ucd9c\ucc98: \ub124\uc774\ubc84)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\n<\/span>\uc0dd\uba85\uccb4\ub77c\ub294 \uac70\ub300\ud558\uace0 \ubcf5\uc7a1\ud55c \uae30\uacc4\ub97c \uc6c0\uc9c1\uc774\ub294 \uac00\uc7a5 \uc791\uc740 \ub2e8\uc704\ub294 \ubb34\uc5c7\uc77c\uae4c?\u00a0<\/span>\uc5f0\uad6c\uc790\ub4e4\uc740 \uc870\uc9c1,\u00a0<\/span>\uc138\ud3ec,\u00a0<\/span>\ub2e8\ubc31\uc9c8, DNA, RNA<\/span>\ub97c \uac70\uccd0\u00a0mRNA<\/span>\uae4c\uc9c0 \uc0dd\uba85\ud604\uc0c1\uc758 \ubbf8\uc138\uc138\uacc4\ub97c \uc18d\uc18d\ub4e4\uc774 \ub4e4\uc5ec\ub2e4\ubcf4\uace0 \uc788\ub2e4.\u00a0<\/span>\ucd5c\uadfc \ubc1d\ud600\uc9c4 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74\u00a0mRNA<\/span>\uc758 \uc6b4\uba85\uc744 \uacb0\uc815\ud558\ub294 \ub370\u00a0\u2018<\/span>\uaf2c\ub9ac\u2019<\/span>\uac00 \uc544\uc8fc \uc911\uc694\ud55c \ub2e8\uc11c\ub85c \uae09\ubd80\uc0c1\ud558\uace0 \uc788\ub2e4\uace0 \ud55c\ub2e4.\u00a0<\/span>\uaf2c\ub9ac\uac00 \uae38\uba74 \uc7a1\ud788\ub294 \ubc95! mRNA<\/span>\uc5d0 \ub2ec\ub9b0 \uaf2c\ub9ac\uac00 \ub3c4\ub300\uccb4 \ubb34\uc5c7\uc778\uc9c0 \uad81\uae08\ud558\ub2e4\uba74 \uc9c0\uae08\ubd80\ud130 \uaf2c\ub9ac\ub97c \uc7a1\uc73c\ub7ec \ub5a0\ub098\ubcf4\uc790.
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\ub2e8\ubc31\uc9c8\uacfc \uc138\ud3ec\uc758 \uc6b4\uba85\uc744 \uacb0\uc815\ud558\ub294 \uc874\uc7ac, mRNA<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc774\uc57c\uae30\ub97c \uc804\ub2ec\ud558\ub294 \uc804\ub2ec\uc790\uc5d0 \ub530\ub77c \uccad\uc911\uc758 \uc774\ud574\ub3c4\uc640 \ubc18\uc751\uc774 \ub2ec\ub77c\uc9c0\ub294 \uac83\ucc98\ub7fc \uc720\uc804\uc815\ubcf4\ub97c \ub2f4\uace0\u00a0mRNA<\/span>\uc5d0 \ub530\ub77c \ub2e8\ubc31\uc9c8\uacfc \uc138\ud3ec\uc758 \uc6b4\uba85\uc774 \ubc14\ub010\ub2e4. mRNA<\/span>\uac00 \uc804\ub2ec\ud558\ub294 \uba54\uc2dc\uc9c0\uc778 \uc720\uc804\uc815\ubcf4\ub294 \uc5fc\uae30 \uc885\ub958\uc640 \uae38\uc774\ub85c \ud45c\ud604\ub41c\ub2e4. DNA<\/span>\ub294 \uc544\ub370\ub2cc(A),\u00a0<\/span>\uad6c\uc544\ub2cc(G),\u00a0<\/span>\uc2dc\ud1a0\uc2e0(C),\u00a0<\/span>\ud2f0\ubbfc(T)\u00a0<\/span>\ub124 \uac00\uc9c0\uc758 \uc5fc\uae30\ub85c \uc774\ub904\uc838 \uc788\ub294 \ubc18\uba74\u00a0RNA<\/span>\ub294 \ud2f0\ubbfc \ub300\uc2e0 \uc6b0\ub77c\uc2e4(U)<\/span>\uc774\ub77c\ub294 \uc5fc\uae30\ub97c \uac00\uc9c0\uace0 \uc788\ub2e4.\u00a0<\/span>\uc720\uc804\uc815\ubcf4\ub294 \uc774 \uc5fc\uae30\ub4e4\uc758 \uc870\ud569\uc73c\ub85c \uad6c\uc131\ub418\uc5b4 \uc5c4\uccad\ub098\uac8c \uae34 \uc871\uc790\ucc98\ub7fc \ub298\uc5b4\uc838 \uc788\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc778\uac04 \uac8c\ub188 \uc9c0\ub3c4\uac00 \ub9cc\ub4e4\uc5b4\uc9c0\uae30 \uc804\uae4c\uc9c0\ub9cc \ud574\ub3c4 \uc778\uac04\uc758 \ubab8\uc744 \uad6c\uc131\ud558\ub294 \ubaa8\ub4e0 \ub2e8\ubc31\uc9c8\uc740\u00a0DNA<\/span>\uc758 \uc720\uc804\uc815\ubcf4\ub85c\ub9cc \uacb0\uc815\ub418\uace0, RNA<\/span>\ub294\u00a0DNA<\/span>\uc758 \uc720\uc804\uc815\ubcf4\ub97c \ub2e8\uc21c\ud788 \ubcf5\uc0ac\ud558\ub294 \uac83\uc73c\ub85c\ub9cc \uc5ec\uaca8\uc84c\ub2e4.\u00a0<\/span>\uc2dc\uac04\uc774 \ud758\ub7ec \uacfc\ud559\uc790\ub4e4\uc5d0 \uc758\ud574\u00a0RNA<\/span>\ub3c4 \ub3c5\uc790\uc801\uc73c\ub85c \uc720\uc804\uc790 \ubcc0\ud615\uc744 \uc77c\uc73c\ud0a8\ub2e4\ub294 \uac8c \ubc1d\ud600\uc84c\ub2e4.\u00a0<\/span>\ud604\uc7ac\uae4c\uc9c0 \ubcf4\uace0\ub41c\u00a0RNA\u00a0<\/span>\ubcc0\uc774 \ud604\uc0c1\ub9cc\u00a01,800<\/span>\uac00\uc9c0\uac00 \ub118\ub294\ub2e4. RNA<\/span>\uc758 \ubcc0\ud615\uc740 \uc804\uc0ac \uacfc\uc815\uc5d0\uc11c\u00a0DNA<\/span>\uc5d0 \uc5c6\ub358 \ubcc0\uc774\uac00 \uc0c8\ub86d\uac8c \uc0dd\uae30\uac70\ub098 \uc5fc\uae30\uc758 \uc21c\uc11c\uac00 \ubc14\ub00c\ub294 \ubc29\uc2dd\uc73c\ub85c \ubc1c\uc0dd\ud55c\ub2e4.\u00a0<\/span>\ubb38\uc81c\ub294\u00a0RNA<\/span>\ub9cc\uc758 \uc798\ubabb\ub41c \ubcc0\uc774\uac00 \uc774\uc0c1 \ub2e8\ubc31\uc9c8\uc744 \ud569\uc131\ud574 \uc9c8\ubcd1\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\ub2e4\ub294 \ub370 \uc788\ub2e4.\u00a0<\/span>\ub354 \ud070 \ubb38\uc81c\ub294\u00a0RNA\u00a0<\/span>\uc790\uccb4\uac00 \ubcc0\uc774\ub97c \uc77c\uc73c\ud0a8\ub2e4\uba74\u00a0DNA<\/span>\ub9cc\uc73c\ub85c \uc778\uccb4\uc758 \uc720\uc804\uc815\ubcf4\ub97c \uc81c\ub300\ub85c \ud30c\uc545\ud560 \uc218 \uc5c6\ub2e4\ub294 \uc810\uc774\ub2e4.
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mRNA\uac00 \uc9c0\ub2cc \uc544\ub370\ub2cc \uaf2c\ub9ac\uc758 \uae38\uc774\ub294?<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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RNA\ub294 \uc138\ud3ec\ud575 \uc548\uc5d0\uc11c \uc804\uc0ac \uacfc\uc815\uc774 \uc9c4\ud589\ub418\uba70, RNA\uac00 \uc138\ud3ec\uc9c8\ub85c \uc6b4\ubc18\ub418\uc5b4 \ub9ac\ubcf4\uc19c\uc5d0 \uc758\ud574 \ubc88\uc5ed\ub41c\ub2e4. \uc804\ub839RNA\uac00 \uc0dd\uc744 \ub9c8\uce58\uba74(\uc804\uc0ac\uc640 \ubc88\uc5ed\uc774 \uc885\ub8cc\ub41c \ud6c4) \ud1f4\ud654 \ud6c4 \uc18c\uba78\ud55c\ub2e4. (\uc0ac\uc9c4 : \uc704\ud0a4\ubc31\uacfc)<\/span><\/span><\/div>\n<\/div>\n

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\uc138\ud3ec\uc758 \uc2e0\ud638\uc804\ub2ec\ubd80\ud130 \uc720\uc804\uc790 \ubc1c\ud604\uae4c\uc9c0,\u00a0<\/span>\uc0dd\uba85 \ud65c\ub3d9\uc758 \ud575\uc2ec\uc774 \ub418\ub294 \ubb3c\uc9c8\u00a0mRNA<\/span>\ub294 \uc138\ud3ec\uc758 \uc6b4\uba85\uc744 \uacb0\uc815\uc9d3\ub294\ub2e4.\u00a0<\/span>DNA<\/i><\/span>\uc5d0 \ubcf4\uad00\ub41c \uc720\uc804\uc815\ubcf4\ub97c \ub2e8\ubc31\uc9c8\ub85c \uc804\ub2ec\ud558\ub294 \ub9e4\uac1c\uccb4\uc774\uae30 \ub54c\ubb38\uc774\ub2e4<\/i>. RNA<\/i><\/span>\uc640\u00a0<\/i>DNA<\/i><\/span>\uc758 \uc0ac\uc774<\/i>,\u00a0<\/i><\/span>\uc720\uc804\uc815\ubcf4\uc640 \uc0dd\uba85\ud65c\ub3d9\uc758 \uc0ac\uc774\ub97c \uc5f0\uacb0\ud558\ub294 \uac8c \ubc14\ub85c\u00a0<\/i>mRNA<\/i><\/span>\uc778 \uc148\uc774\ub2e4<\/i>.<\/i><\/span>\u00a0mRNA<\/span>\uac00 \ubcf8\uc5f0\uc758 \uc77c\uc744 \uc218\ud589\ud558\uae30 \uc704\ud574\uc120 \uc131\uc219 \uacfc\uc815\uc774 \ud544\uc694\ud558\ub2e4.\u00a0<\/span>\uadf8 \uc911 \ud558\ub098\uac00\u00a0mRNA\u00a0<\/span>\ub4a4\ucabd \ub9d0\ub2e8\uc5d0\u00a0\u2018<\/span>\uc544\ub370\ub2cc(A)\u2019<\/span>\uc73c\ub85c \uad6c\uc131\ub41c\u00a0AAAA….<\/span>\ub85c \uae38\uac8c \ub298\uc5b4\uc120 \uaf2c\ub9ac\ub97c \uac16\ub294 \uac83\uc774\ub2e4.
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\uc544\ub370\ub2cc \uaf2c\ub9ac\uac00\u00a0mRNA\uc758 \uc6b4\uba85\uc744 \uacb0\uc815\ud558\ub294 \uc911\uc694 \uc694\uc18c\uc778 \ub9cc\ud07c \uc138\uacc4 \uc5ec\ub7ec \uc5f0\uad6c \uadf8\ub8f9\uc740 \uaf2c\ub9ac \uae38\uc774\ub97c \uc815\ud655\ud788 \uce21\uc815\ud558\uae30 \uc704\ud55c \uc5f0\uad6c\ub97c \uacc4\uc18d\ud574 \uc654\ub2e4.\u00a0\ud558\uc9c0\ub9cc \uae30\uc874\uc758 \uc5fc\uae30\uc11c\uc5f4\ubd84\uc11d\uae30\ub85c\ub294 \uc544\ub370\ub2cc \uaf2c\ub9ac \uae38\uc774\ub97c \uc815\ud655\ud788 \uce21\uc815\ud558\ub294 \ub370 \ud55c\uacc4\uac00 \uc788\uc5c8\ub2e4.\u00a0\uae34 \uc544\ub370\ub2cc \uaf2c\ub9ac\ub294 \uc544\ub370\ub2cc\ub9cc \uc5f0\uc18d\uc801\uc73c\ub85c \uae38\uac8c \uad6c\uc131\ub418\uc5b4 \uc788\uc5b4 \uc2e0\ud638\uac00 \ubc18\ubcf5\uc801\uc73c\ub85c \ub098\uc640 \uae68\ub057\ud558\uac8c \ubd84\uc11d\ud558\uae30 \uc5b4\ub835\uace0,\u00a0\uc138\ud3ec \ud558\ub098\uc5d0\uc11c \uc5bb\uc744 \uc218 \uc788\ub294\u00a0mRNA\uc758 \uc591\ub3c4 \ub9e4\uc6b0 \uc801\uae30 \ub54c\ubb38\uc774\ub2e4.
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\uaf2c\ub9ac\uac00 \uae38\uba74 \uce21\uc815\ub418\ub294 \ubc95, TAIL-seq \uac1c\ubc1c<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uadf8\ub7f0\ub370 \uc9c0\ub09c\u00a02014<\/span>\ub144\u00a03<\/span>\uc6d4,\u00a0<\/span>\uae30\ucd08\uacfc\ud559\uc5f0\uad6c\uc6d0(IBS) RNA\u00a0<\/span>\uc5f0\uad6c\ub2e8 \uae40\ube5b\ub0b4\ub9ac \ub2e8\uc7a5(<\/span>\uc11c\uc6b8\ub300 \uc0dd\uba85\uacfc\ud559\ubd80 \uc11d\uc88c\uad50\uc218)\u00a0<\/span>\uc5f0\uad6c\ud300\uc774 \uae34 \uc544\ub370\ub2cc \uaf2c\ub9ac \uce21\uc815\uc758 \ud55c\uacc4\ub97c \uadf9\ubcf5\ud560 \uc0c8\ub85c\uc6b4 \uae30\uc220\uc744 \uac1c\ubc1c\ud574 \ud559\uacc4\uc758 \ud070 \uc8fc\ubaa9\uc744 \ubc1b\uc558\ub2e4.\u00a0<\/span>\uc5f0\uad6c \uacb0\uacfc\ub294\u00a0\u2018<\/span>\ubab0\ub808\ud058\ub7ec \uc140(Molecular Cell)\u2019<\/span>\uc5d0 \uac8c\uc7ac\ub418\uc5c8\ub2e4.\u00a0<\/span>\uc5f0\uad6c\ud300\uc774 \uac1c\ubc1c\ud55c \ubc29\ubc95\uc740 \uae34 \uc544\ub370\ub2cc \uaf2c\ub9ac \uae38\uc774\uc640 \uaf2c\ub9ac\ub97c \uad6c\uc131\ud558\ub294 \uc5fc\uae30\uc11c\uc5f4\uc744 \ub9c8\uce58 \ubb38\uc790 \ud558\ub098\ud558\ub098 \ud574\ub3c5\ud558\ub4ef \ubd84\uc11d\ud560 \uc218 \uc788\ub2e4.\u00a0<\/span>\uc720\uc804\uccb4 \uc804\uccb4 \uc218\uc900\uc5d0\uc11c \uae34 \uc544\ub370\ub2cc \uaf2c\ub9ac\ub97c \uc815\ud655\ud788 \uc7b4 \uc218 \uc788\uace0, mRNA<\/span>\uc758 \ud2b9\uc131\uc744 \ub300\uaddc\ubaa8\ub85c \uc0ac\uc9c4 \ucc0d\ub4ef \ubd84\uc11d\ud560 \uc218 \uc788\ub2e4.\u00a0<\/span>\uc5f0\uad6c\uc9c4\uc740 \uc774 \uae30\uc220\uc758 \uc774\ub984\uc744\u00a0\u2018<\/span>\uaf2c\ub9ac\uc11c\uc5f4\ubd84\uc11d\ubc95(TAIL-seq)\u2019<\/span>\ub85c \uc9c0\uc5c8\ub2e4.\u00a0<\/span>\uaf2c\ub9ac\uc11c\uc5f4\ubd84\uc11d\ubc95\uc744 \ub2e4\uc591\ud55c \uc138\ud3ec\ub098 \uc870\uc9c1\uc5d0 \uc801\uc6a9\ud560 \uacbd\uc6b0,\u00a0<\/span>\uae30\uc874 \uc5f0\uad6c\ubc29\ubc95\uc73c\ub85c\ub294 \uc54c \uc218 \uc5c6\uc5c8\ub358 \uc0dd\uba85 \ud604\uc0c1\uc744 \ud574\uc11d\ud560 \uc218 \uc788\ub2e4.<\/span><\/p>\n

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IBS RNA \uc5f0\uad6c\ub2e8\uc774 \uac1c\ubc1c\ud55c \ubd84\uc11d\ubc95\uc758 \ud575\uc2ec\uc740 \uae38\uc7a1\uc774\uc778 \uc5b4\ub311\ud130\uc640 \uaf2c\ub9ac 2\ubc29\ud5a5 \uc77d\uae30\uc5d0 \uc788\ub2e4. mRNA\uc5d0 \uaf2c\ub9ac \uc5b4\ub311\ud130\ub97c \ub4a4 \ucabd\uc5d0 \ubd99\uc774\uace0 mRNA\uc758 \uc5fc\uae30 \uc11c\uc5f4 \uc911 \uad6c\uc544\ub2cc \ub4a4\ub97c \uc784\uc758 \uc808\ub2e8\ud55c \ud6c4, \uc55e\ubd80\ubd84\uc5d0 \uc5b4\ub311\ud130\ub97c \ucd94\uac00\ub85c \ubd99\uc778\ub2e4. \uc5b4\ub311\ud130\uac00 \ubd99\uc740 RNA\ub294 DNA\ub85c \uc804\ud658\ub41c \ud6c4, \ucc28\uc138\ub300 \uc5fc\uae30\uc11c\uc5f4\ubd84\uc11d\uae30\uc5d0\uc11c \ud615\uad11\uc2e0\ud638 \ubd84\uc11d\uc744 \ud1b5\ud574 \uac01\uac01\uc758 \uae34 \uc544\ub370\ub2cc \uaf2c\ub9ac\uac00 \uce21\uc815\ub41c\ub2e4. (\uc0ac\uc9c4 : IBS)<\/span><\/span><\/p>\n<\/div>\n<\/div>\n

\uc5f0\uad6c\ud300\uc740 \uc544\ub370\ub2cc \uaf2c\ub9ac\uc5d0\uc11c \ubc18\ubcf5\ub418\ub294 \uc544\ub370\ub2cc\uc73c\ub85c \uc778\ud574 \uc11c\uc5f4 \ubd84\uc11d\uc774 \uba85\ud655\uce58 \uc54a\uc740 \uc810\uc744 \ubcf4\uc644\ud558\uace0\uc790 \ubd84\uc11d \ub3c4\uc911 \ub098\uc624\ub294 \ud615\uad11 \uc2e0\ud638\ub97c \uae30\uacc4\uc801 \ud559\uc2b5\ubc95\uc73c\ub85c \ubd84\uc11d\ud574 \uaf2c\ub9ac \uae38\uc774\ub97c \uce21\uc815\ud560 \uc218 \uc788\uac8c \ub9cc\ub4e4\uc5c8\ub2e4.\u00a0<\/span>\uc5f0\uad6c\ud300\uc740 \uc790\uad81\uacbd\ubd80\uc554\uc138\ud3ec\uc8fc\uc640 \uc0dd\uc950\uc758 \uc12c\uc720\uc544\uc138\ud3ec \ub0b4\u00a0mRNA\u00a0<\/span>\uaf2c\ub9ac\uc758 \uc2dc\uc791\uacfc \ub05d\uc5d0 \uc5b4\ub311\ud130\ub97c \ubd99\uc600\ub2e4.\u00a0<\/span>\uc5b4\ub311\ud130\ub294 \ud654\ud559\uc801\uc73c\ub85c \ud569\uc131\ub41c \ud575\uc0b0 \uc870\uac01\uc73c\ub85c \uc774\ubbf8 \uc54c\uace0 \uc788\ub294 \uc11c\uc5f4\uc758 \uc5fc\uae30\ub85c \uad6c\uc131\ub418\uc5b4 \uc788\ub2e4.\u00a0<\/span>\uc5b4\ub311\ud130\ub97c \ubd99\uc778 \ub2e4\uc74c \ucc28\uc138\ub300 \uc5fc\uae30\uc11c\uc5f4\ubd84\uc11d\uae30\uc5d0 \uaf2c\ub9ac\ub97c \uba38\ub9ac\ubd80\ud130 \uc21c\uc11c\ub300\ub85c \uc77d\ub294 \uc815\ubc29\ud5a5\uacfc \uaf2c\ub9ac\ubd80\ud130 \uc21c\uc11c\ub300\ub85c \uc77d\ub294 \uc5ed\ubc29\ud5a5,\u00a0<\/span>\ucd1d\u00a02<\/span>\ubc88\uc744 \uc77d\uac8c \ud588\ub354\ub2c8 \uaf2c\ub9ac \uae38\uc774\ub294 \ubb3c\ub860 \uaf2c\ub9ac\uc758 \ub9d0\ub2e8 \uc5fc\uae30\uc11c\uc5f4\ub3c4 \ud655\uc778\ud558\ub294 \ub370 \uc131\uacf5\ud588\ub2e4.
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\uc5f0\uad6c\ud300\uc774 \uac1c\ubc1c\ud55c \uaf2c\ub9ac\uc11c\uc5f4\ubd84\uc11d\ubc95\uc740 \uae30\uc874 \uc5f0\uad6c \ubc29\ubc95\uc73c\ub85c\ub294 \uc54c \uc218 \uc5c6\uc5c8\ub358 \uc0dd\uba85 \ud604\uc0c1\uc744 \ud574\uc11d\ud558\ub294\ub370 \ud070 \ub3c4\uc6c0\uc774 \ub420 \uac83\uc73c\ub85c \ubcf4\uc778\ub2e4.\u00a0\uc2e4\uc81c \uc2e4\ud5d8\uacb0\uacfc, mRNA\u00a0\uaf2c\ub9ac\ub294 \uc131\uc219 \uacfc\uc815 \uc911 \uc544\ub370\ub2cc\u00a0200\uac1c \uc815\ub3c4\uac00 \uc774\uc5b4\uc838 \uae30\ub2a5\ud55c\ub2e4\uace0 \uc54c\ub824\uc838 \uc788\uc5c8\uc73c\ub098 \uce21\uc815\ud574\ubcf4\ub2c8\u00a060~70\uac1c\ub85c \ud6e8\uc52c \uc9e7\uac8c \ub098\ud0c0\ub0ac\ub2e4.\u00a0\uae30\uc874\uc5d0 \uc54c\ub824\uc84c\ub358 \uae38\uc774\uc5d0 \ube44\ud574\u00a01\/3\ubc16\uc5d0 \ub418\uc9c0 \uc54a\ub294 \uac83.\u00a0<\/span>\ub610 \uc544\ub370\ub2cc \uaf2c\ub9ac \uae38\uc774\ub294\u00a0mRNA\uc758 \ubd84\ud574 \uc18d\ub3c4\uc640\ub294 \uc5f0\uad00\uc131\uc774 \uc788\uc5c8\uc9c0\ub9cc \ub2e8\ubc31\uc9c8 \ubc88\uc5ed \ud6a8\uc728\uacfc\ub294 \uad00\uacc4\uac00 \uc5c6\ub2e4\ub294 \uc0ac\uc2e4\ub3c4 \ubc1d\ud600\uc84c\ub2e4.<\/span><\/span><\/p>\n

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mRNA \ube60\ub974\uac8c \ubd84\ud574\ub418\ub294 \ud604\uc0c1\uacfc \uc138\ud3ec \uc8fc\uae30\uc5d0\ub3c4 \uc544\ub370\ub2cc \uaf2c\ub9ac\uac00?<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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BS\u00a0<\/span>\uc5f0\uad6c\uc9c4\uc774 \uac1c\ubc1c\ud55c \uaf2c\ub9ac\uc11c\uc5f4\ubd84\uc11d\ubc95\uc774 \ud559\uacc4\uc758 \uc8fc\ubaa9\uc744 \ub048 \ub610 \ub2e4\ub978 \uc774\uc720\uac00 \uc788\ub2e4.\u00a0<\/span>\uc9c0\uae08\uae4c\uc9c0 \uc54c\uc838\uc9c0\uc9c0 \uc54a\uc740\u00a0mRNA<\/span>\uc758 \ubd84\ud574 \uacfc\uc815\uc5d0 \uc228\uaca8\uc9c4\u00a0\uc720\ub9ac\ub518\ud654 \uacfc\uc815\uc744 \ucc98\uc74c\uc73c\ub85c \ubc1c\uacac\ud55c \uac83\uc774\ub2e4.\u00a0<\/span>\uc131\uc219 \uacfc\uc815\uc744 \uac70\uccd0 \uae34 \uc544\ub370\ub2cc \uaf2c\ub9ac\ub97c \uac16\uac8c \ub41c\u00a0mRNA<\/span>\ub294 \ub9e1\uc740 \uc77c\uc744 \ub2e4 \ub9c8\uce58\uba74 \uc544\ub370\ub2cc \uaf2c\ub9ac\uac00 \uc9e7\uc544\uc9c0\uba74\uc11c \uc798\uac8c \ubd84\ud574\ub3fc \uacb0\uad6d \uc0b0\ud654\ud55c\ub2e4.\u00a0<\/span>\uc5f0\uad6c \uacb0\uacfc,\u00a0<\/span>\uc5f0\uad6c\uc9c4\uc740 \uc544\ub370\ub2cc \uaf2c\ub9ac\uac00 \uc9e7\uc544\uc9c4\u00a0mRNA\u00a0<\/span>\ub05d\ubd80\ubd84\uc5d0 \uc720\ub9ac\ub518(<\/span>\uc6b0\ub77c\uc2e4(U)<\/span>\uc5d0 \ub2f9(<\/span>\ub9ac\ubcf4\uc624\uc2a4)<\/span>\uac00 \uacb0\ud569\ub41c \uac83)\u00a0<\/span>\uaf2c\ub9ac\uac00 \uc0dd\uae30\uba74\uc11c\u00a0mRNA<\/span>\uac00 \ub354\uc6b1 \ube60\ub974\uac8c \ubd84\ud574\ub41c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uad00\ucc30\ud588\ub2e4. AAA<\/span>\ub85c \ub05d\ub098\ub294\u00a0mRNA\u00a0<\/span>\uc5fc\uae30\uc11c\uc5f4 \ub05d\uc5d0\ub294\u00a0UUU<\/span>\uac00 \ub2ec\ub77c\ubd99\ub294\ub2e4\ub294 \uc598\uae30\ub2e4.<\/span><\/p>\n

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\uc131\uc219\ud55c mRNA\ub294 \uae34 \uc544\ub370\ub2cc \uaf2c\ub9ac(poly[A]tail)\ub97c \uac00\uc9c0\uace0 \uc788\ub294\ub370, \uae30\ub2a5\uc744 \ub9c8\uce5c \uc804\ub839RNA\ub294 \uc544\ub370\ub2cc \uaf2c\ub9ac\uac00 \uc9e7\uc544\uc9c0\uba74\uc11c \ubd84\ud574\uac00 \uc2dc\uc791\ub41c\ub2e4. \uc544\ub370\ub2cc \uaf2c\ub9ac\uac00 \uc9e7\uc544\uc9c4 \uc804\ub839RNA\ub294 TUT4, TUT7 \ud6a8\uc18c\uc5d0 \uc758\ud574 \ucd94\uac00\ub85c \uc720\ub9ac\ub518 \uaf2c\ub9ac\ub97c \uac00\uc9c0\uac8c \ub418\uba74\uc11c \ub354\uc6b1 \ube68\ub9ac \ubd84\ud574\ub41c\ub2e4. (\uc0ac\uc9c4 : IBS)<\/span><\/span><\/div>\n<\/div>\n

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\uc5f0\uad6c\ud300\uc740 \ubd84\ud574\ub97c \uac00\uc18d\ud654\uc2dc\ud0a4\ub294 \uc6d0\uc778\uc774 \ubb34\uc5c7\uc778\uc9c0 \uc0b4\ud3b4\ubcf4\ub358 \uc911\u00a0\u2018TUT4\u2019<\/span>\uc640\u00a0\u2018TUT7\u2019\u00a0<\/span>\ub450 \ud6a8\uc18c\uc5d0 \uc9d1\uc911\ud588\ub2e4.\u00a0<\/span>\uc2e4\ud5d8\uc73c\ub85c \ub450 \ud6a8\uc18c\ub97c \uc778\uc704\uc801\uc73c\ub85c \uc81c\uac70\ud588\ub354\ub2c8\u00a0mRNA<\/span>\uc5d0\uc11c \uc720\ub9ac\ub518 \uaf2c\ub9ac\uac00 \uc0ac\ub77c\uc9c0\uba70 \ubd84\ud574\uac00 \ub290\ub824\uc9c4 \uac83\uc744 \uad00\ucc30\ud588\ub2e4.
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\n\ub098\uc544\uac00 \uc5f0\uad6c\uc9c4\uc740 \uc9e7\uc740 \uc544\ub370\ub2cc \uaf2c\ub9ac\uc640 \uae34 \uc544\ub370\ub2cc \uaf2c\ub9ac \ub4a4\uc5d0 \ubd99\ub294 \uc5fc\uae30\uac00 \ub2e4\ub974\ub2e4\ub294 \uac83\ub3c4 \uad00\ucc30\ud588\ub2e4<\/i>.\u00a0<\/i><\/span>\uc9e7\uc740 \uc544\ub370\ub2cc \uaf2c\ub9ac \ub4a4\uc5d0\ub294 \ud2b9\ud788 \uc720\ub9ac\ub518\uc774<\/i>,\u00a0<\/i><\/span>\uae34 \uc544\ub370\ub2cc \uaf2c\ub9ac \ub4a4\uc5d0\ub294 \uad6c\uc544\ub2cc\uc774 \uc790\uc8fc \ubd99\uc5c8\ub2e4<\/i>.\u00a0<\/i><\/span>\uc5f0\uad6c\ud300\uc740 \uc720\ub9ac\ub518 \uaf2c\ub9ac\ub294\u00a0<\/i>mRNA<\/i><\/span>\uc758 \ubd84\ud574\ub97c<\/i>,\u00a0<\/i><\/span>\uad6c\uc544\ub2cc \uaf2c\ub9ac\ub294\u00a0<\/i>mRNA<\/i><\/span>\uc758 \uc548\uc815\ud654\ub97c \uc720\ub3c4\ud558\ub294 \uac83\uc73c\ub85c \ucd94\uc815\ud588\ub2e4<\/i>.\u00a0<\/i><\/span>\uc5f0\uad6c\uc9c4\uc740\u00a0<\/i>mRNA<\/i><\/span>\uc758 \ubd84\ud654\uc640 \uc548\uc815\ud654\ub97c \ub450 \uc5fc\uae30\uac00 \uc870\uc808\ud558\ub294 \uac83\uc73c\ub85c \ubcf4\uc558\uc744 \ub54c<\/i>,\u00a0<\/i><\/span>\uc720\ub9ac\ub518\ud654 \uc5f0\uad6c\uac00 \uc720\uc804\uc790 \uc870\uc808\uc744 \uc774\ud574\ud558\ub294 \ub370 \ud070 \ub3c4\uc6c0\uc774 \ub420 \uac83\uc774\ub77c\uace0 \uae30\ub300\ud558\uace0 \uc788\ub2e4<\/i>.<\/i><\/span>
\n<\/span>
\n<\/span>\ub610\ud55c\u00a0IBS\u00a0\uc5f0\uad6c\ud300\uc740 \uc138\ud3ec \uc8fc\uae30\ub97c \uc870\uc808\ud558\ub294 \uacb0\uc815\uc801 \uc694\uc778\uc774 \ub2e8\ubc31\uc9c8\uc774 \uc544\ub2cc\u00a0mRNA\uc758 \uc544\ub370\ub2cc \uaf2c\ub9ac\ub77c\ub294 \uc0ac\uc2e4\uc744 \uc54c\uc544\ub0c8\ub2e4.\u00a0\uc138\ud3ec \uc8fc\uae30\uc5d0 \ub530\ub77c\u00a0mRNA\u00a0\uc544\ub370\ub2cc \uaf2c\ub9ac\uac00 \ub2ec\ub77c\uc9c0\ub294 \ud604\uc0c1\uc744 \ud655\uc778\ud55c \uac83.\u00a0\uc138\ud3ec \uc8fc\uae30\ub294 \ud06c\uac8c \uac04\uae30\uc640 \ubd84\uc5f4\uae30\ub85c \ub098\ub258\ub294\ub370 \uc138\ud3ec \uc8fc\uae30 \uc870\uc808\uc5d0 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 \uc720\uc804\uc790\ub4e4\uc758\u00a0mRNA\u00a0\uc544\ub370\ub2cc \uaf2c\ub9ac\uac00 \uc138\ud3ec\uc758 \ubd84\uc5f4\uae30\uc5d0\u00a020\uac1c \uc774\ud558\ub85c \uc9e7\uc544\uc9c0\uba74\uc11c \ubc88\uc5ed\uc774 \uac10\uc18c\ud568\uc744 \uad00\ucc30\ud588\ub2e4.\u00a0\uc5f0\uad6c\ud300\uc740 \uc720\uc804\uc790\ub4e4\uc758 \ub2e8\ubc31\uc9c8 \ubc88\uc5ed\uc774 \uac10\uc18c\ud574\uc57c \ub2e4\uc74c \uc8fc\uae30\ub85c \ub118\uc5b4\uac08 \uc218 \uc788\uae30 \ub54c\ubb38\uc774\ub77c\uace0 \uc124\uba85\ud588\ub2e4.\u00a0\uae40\ube5b\ub0b4\ub9ac \ub2e8\uc7a5\uc740\u00a0\u201c2016\ub144\u00a05\uc6d4 \ubab0\ub808\ud058\ub7ec\uc5d0 \uc2e4\ub838\ub358 \uc774 \uacb0\uacfc\ub294 \uc138\ud3ec \uc8fc\uae30\uc640 \uad00\ub828\ub41c \uc5ec\ub7ec \uc9c8\ubcd1\uc744 \uc774\ud574\ud558\ub294 \uc911\uc694\ud55c \uc2e4\ub9c8\ub9ac\uac00 \ub420 \uac83\u201d\uc774\ub77c\uba70\u00a0\u201c\ud5a5\ud6c4\u00a0mRNA\uc5d0 \uacb0\ud569\ud558\ub294 \ub2e8\ubc31\uc9c8\uc774 \uc138\ud3ec \uc8fc\uae30 \uc870\uc808\uc5d0 \uc5b4\ub5a4 \uc5ed\ud560\uc744 \ud558\ub294\uc9c0 \uc5f0\uad6c\ud560 \uacc4\ud68d\u201d\uc774\ub77c\uace0 \ubc1d\ud614\ub2e4.<\/span><\/span><\/p>\n

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mRNA \uc544\ub370\ub2cc \uaf2c\ub9ac\uc5d0 \uc0ac\uc2e4\uc740 \ub2e4\ub978 \uc5fc\uae30\ub4e4\ub3c4 \uc788\uc5c8\ub2e4<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\ucd5c\uadfc\uc5d0\ub3c4\u00a0IBS\u00a0<\/span>\uc5f0\uad6c\ud300\uc740 \uc138\uacc4 \ucd5c\ucd08\ub85c\u00a0mRNA<\/span>\uc758 \ubd84\ud574\ub97c \ub9c9\ub294\u00a0\u2018<\/span>\ud63c\ud569 \uaf2c\ub9ac\u2019<\/span>\uc758 \uae30\ub2a5\uc744 \ubc1c\uacac\ud588\ub2e4.\u00a0<\/span>\uc9c0\uae08\uae4c\uc9c0 \uc21c\uc218\ud558\uac8c \uc544\ub370\ub2cc \uaf2c\ub9ac\ub9cc\uc73c\ub85c \uad6c\uc131\ub418\uc5c8\ub2e4\uace0 \uc5ec\uaca8\uc84c\ub358 \uc544\ub370\ub2cc \uaf2c\ub9ac\uc5d0 \uc6b0\ub77c\uc2e4\uc774\ub098 \uad6c\uc544\ub2cc\uc774 \ud63c\ud569\ub418\uc5b4 \uc874\uc7ac\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ud655\uc778\ud55c \uac83\uc774\ub2e4. mRNA<\/span>\uc758 \uc0dd\uc560\uc640 \uc720\uc804\uc790 \uc870\uc808\uc5d0 \uad00\ud55c \uc0c8 \uc774\ub860\uc744 \uc81c\uc2dc\ud55c \uc774 \uc5f0\uad6c\ub294 \uc62c\ud574\u00a07<\/span>\uc6d4 \uc0ac\uc774\uc5b8\uc2a4(Science)<\/span>\uc5d0 \uc2e4\ub838\ub2e4.\u00a0<\/span><\/p>\n

\uc5f0\uad6c\ud300\uc740 \uc790\uccb4 \uac1c\ubc1c\ud55c \uaf2c\ub9ac\uc11c\uc5f4\ubd84\uc11d\ubc95\uc744 \uc801\uc6a9\ud574 \ud63c\ud569\uaf2c\ub9ac\uc758 \uc874\uc7ac\ub97c \ud655\uc778\ud588\ub2e4.\u00a0<\/span>\uc5f0\uad6c\uc9c4\uc740 \uc0ac\ub78c\uc758 \uc138\ud3ec\ubfd0\ub9cc \uc544\ub2c8\ub77c \uac1c\uad6c\ub9ac\uc640 \ubb3c\uace0\uae30\uc758 \ud0dc\uc544\uc138\ud3ec\uc5d0\uc11c\ub3c4 \ud63c\ud569 \uaf2c\ub9ac\ub97c \ubc1c\uacac\ud574,\u00a0<\/span>\ud63c\ud569 \uaf2c\ub9ac\uac00 \ub2e4\uc591\ud55c \uc885\uc5d0\uc11c \uc9c4\ud654\uc801\uc73c\ub85c \ubcf4\uc874\ub418\uc5b4 \uc654\ub2e4\uace0 \uc124\uba85\ud588\ub2e4.\u00a0<\/span>\uc544\ub370\ub2cc \uaf2c\ub9ac \ub9d0\ub2e8\uc5d0 \ud63c\ud569 \uaf2c\ub9ac\ub97c \ucd94\uac00\ud558\ub294 \uc5ed\ud560\uc740\u00a0TENT4A<\/span>\uc640\u00a0TENT4B\u00a0<\/span>\ub450 \uac00\uc9c0\u00a0\u2018<\/span>\ub9ac\ubcf4\ud575\uc0b0 \ub9d0\ub2e8 \ubcc0\ud615 \ud6a8\uc18c(TENT4)\u2019<\/span>\uac00 \uc218\ud589\ud55c\ub2e4. TENT4A<\/span>\uc640\u00a0TENT4B\u00a0<\/span>\ud6a8\uc18c\ub97c \uc81c\uac70\ud558\uc790\u00a0mRNA\u00a0<\/span>\ubd84\ud574\uac00 \ucd09\uc9c4\ub418\uc5c8\ub2e4.\u00a0<\/span>\ud63c\ud569 \uaf2c\ub9ac\ub294 \uc544\ub370\ub2cc\ub9cc\uc73c\ub85c \uc774\ub8e8\uc5b4\uc9c4 \uae34 \uc544\ub370\ub2cc \uaf2c\ub9ac\uc5d0 \ube44\ud574 \uc798 \ubd84\ud574\ub418\uc9c0 \uc54a\uae30 \ub54c\ubb38\uc5d0\u00a0mRNA<\/span>\uc758 \ubd84\ud574\ub97c \ub9c9\uc544 \ubcf4\ud638\ud558\uace0, RNA<\/span>\uc758 \uc218\uba85\uc744 \ub298\ub9b0\ub2e4\ub294 \uac8c \uc5f0\uad6c\ud300\uc758 \uc124\uba85\uc774\ub2e4.\u00a0<\/span><\/p>\n

\uc774\ubc88 \uc5f0\uad6c\ub85c \uc544\ub370\ub2cc \uaf2c\ub9ac \uae38\uc774\ub9cc \uc911\uc694\ud55c \uc694\uc18c\ub77c\uace0 \uc5ec\uacbc\ub358 \ud559\uacc4\uc758 \uc0dd\uac01\uc774 \ub610 \ud55c \ubc88 \ubc14\ub00c\uc5c8\ub2e4<\/i>.\u00a0<\/i><\/span>\uc544\ub370\ub2cc \uaf2c\ub9ac \uae38\uc774\uac00 \uac19\ub354\ub77c\ub3c4 \uad6c\uc131<\/i>(<\/i><\/span>\uc9c8\uc801\uc778 \uc815\ubcf4<\/i>)<\/i><\/span>\uc774 \ub2e4\ub97c \uc218 \uc788\uace0<\/i>,\u00a0<\/i><\/span>\ud63c\ud569 \uaf2c\ub9ac\uac00 \uc21c\uc218\ud55c \uaf2c\ub9ac\ubcf4\ub2e4 \ub354 \ub290\ub9ac\uac8c \ubd84\ud574\ub41c\ub2e4\ub294 \uc0ac\uc2e4\uc740 \ud63c\ud569 \uaf2c\ub9ac\ub97c\u00a0<\/i>mRNA<\/i><\/span>\uc5d0 \ucd94\uac00\ud558\uba74 \ubd84\ud574\ub97c \ub2a6\ucd9c \uc218 \uc788\ub2e4\ub294 \uc758\ubbf8\ub2e4<\/i>.\u00a0<\/i><\/span>\ub530\ub77c\uc11c \ud63c\ud569 \uaf2c\ub9ac\uac00<\/i>mRNA<\/i><\/span>\ub97c \ubcf4\ud638\ud558\ub294 \uba54\ucee4\ub2c8\uc998\uc740 \uaf2c\ub9ac \ubcc0\ud615\uc744 \ud1b5\ud574 \uc720\uc804\uc790\uc758 \ubc1c\ud604\uc744 \uc81c\uc5b4\ud558\uace0<\/i>, RNA<\/i><\/span>\ub97c \uc774\uc6a9\ud558\ub294 \uc720\uc804\uc790 \uce58\ub8cc\uc758 \ud6a8\uc728\uc744 \ub192\uc774\ub294 \ub370 \ud65c\uc6a9\ub420 \uc218 \uc788\uc744 \uc804\ub9dd\uc774\ub2e4<\/i>.<\/i><\/span><\/p>\n

\uaf2c\ub9ac\uac00 \uae38\uba74 \uacb0\uad6d \uc7a1\ud788\ub294 \ubc95. mRNA<\/span>\uac00 \uc9c0\ub2cc \uae34 \uc544\ub370\ub2cc \uaf2c\ub9ac\ub294 \uacb0\uad6d\u00a0IBS\u00a0<\/span>\uc5f0\uad6c\uc9c4\uc774 \uac1c\ubc1c\ud55c \uaf2c\ub9ac\uc11c\uc5f4\ubd84\uc11d\ubc95(TAIL-seq)<\/span>\uc5d0 \ubd99\ub4e4\ub824 \ud558\ub098,\u00a0<\/span>\ub458 \uc0dd\uba85\ud604\uc0c1\uc758 \uc0c8\ub85c\uc6b4 \ube44\ubc00\ub4e4\uc744 \ubcf4\uc5ec\uc8fc\uace0 \uc788\ub2e4.\u00a0<\/span>\uc544\ub370\ub2cc \uaf2c\ub9ac\uc640 \ud63c\ud569 \uaf2c\ub9ac, mRNA<\/span>\uc758 \uc6b4\uba85\uc744 \uacb0\uc815\uc9d3\ub294 \uc774 \uaf2c\ub9ac\ub4e4\uc774 \uac00\uc9c4 \ub610 \ub2e4\ub978 \ube44\ubc00\ub4e4\uc740 \ubb34\uc5c7\uc77c\uae4c?
\n<\/span>\uaf2c\ub9ac\ub97c \uc7a1\uc73c\ub824 \uace0\uad70\ubd84\ud22c\ud558\ub294\u00a0IBS\u00a0<\/span>\uc5f0\uad6c\uc9c4\ub4e4\uc5d0\uac8c \uc751\uc6d0\uc744 \ubcf4\ub0b4\ubcf4\uc790.\u00a0<\/span>\uaf2c\ub9ac\ub9cc\uc73c\ub85c \ud559\uacc4\ub97c \ub180\ub77c\uac8c \ud588\ub4ef \uc6b0\ub9ac\ub97c \ub180\ub77c\uac8c \ub9cc\ub4e4 \uac83\ub9cc \uac19\ub2e4.<\/span><\/p>\n

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\uc131\uc219\ud55c mRNA\ub294 \uae34 \uc544\ub370\ub2cc \uaf2c\ub9ac\ub97c \uac00\uc9c0\uace0 \uc788\ub294\ub370, \uc774 \uaf2c\ub9ac\ub294 mRNA\uc758 \ubd84\ud574\ub97c \ub9c9\uace0 \uc815\uc0c1\uc801\uc73c\ub85c \uae30\ub2a5\ud558\ub294\ub370 \ub3c4\uc6c0\uc744 \uc900\ub2e4. \uae34 \uc544\ub370\ub2cc \uaf2c\ub9ac\uac00 \ud0c8\uc544\ub370\ub2d0\ud654 \ud6a8\uc18c\uc5d0 \uc758\ud574 \uc9e7\uc544\uc9c0\uba74\uc11c mRNA\uc758 \ubd84\ud574\uac00 \uc77c\uc5b4\ub098\uac8c \ub418\ub294\ub370, mRNA\uc5d0 \ubd99\uc740 \ud63c\ud569 \uaf2c\ub9ac\ub294 \uc544\ub370\ub2cc \uaf2c\ub9ac \uc81c\uac70 \uacfc\uc815\uc744 \ubc29\ud574\ud55c\ub2e4. \uadf8 \uacb0\uacfc, mRNA\uc758 \ubd84\ud574\uac00 \uc5b5\uc81c\ub418\uc5b4 \uc548\uc815\uc131\uc774 \ub192\uc544\uc9c0\uace0 \uacb0\ub860\uc801\uc73c\ub85c \ud63c\ud569 \uaf2c\ub9ac\ub294 mRNA\uc758 \uc0dd\uc874\uc5d0 \uae30\uc5ec\ud558\uac8c \ub41c\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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 <\/p>\n","protected":false},"excerpt":{"rendered":"

    mRNA \uaf2c\ub9ac\uc5d0 \uad00\ud55c \uc11c\uc6b8\ub300 \uae40\ube5b\ub0b4\ub9ac \uad50\uc218\ub2d8\uc758 \ucd5c\uadfc \ub17c\ubb38 \uc124\uba85\uc785\ub2c8\ub2e4~ (\uc6d0\ubb38)   \ub2e8\ubc31\uc9c8\uacfc \uc138\ud3ec\uc758 \uc6b4\uba85 \uacb0\uc815\uc790, \uc804\ub839RNA(mRNA) \uace0\ud608\uc555 \ud658\uc790\uc640 \ub9c8\ub77c\ud1a4 \uc120\uc218\uc758 \uacf5\ud1b5\uc810\uc774 \uc788\ub2e4.\u00a0\uc2ec\uc7a5\uc774 \uc77c\ubc18(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[33,34,29,30],"tags":[],"class_list":["post-1876","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-chemistry","category-lets-do-science","category-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":3893,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3893","url_meta":{"origin":1876,"position":0},"title":"Epigenetics comes to RNA","author":"biochemistry","date":"July 16, 2019","format":false,"excerpt":"\u00a0 \u00a0 An enzyme (pink) places a chemical mark (gold) on messenger RNA (blue), in an artist's concept. IMAGE: STORM THERAPEUTICS \u00a0 \u00a0 The idea that chemical tags on genes can affect their expression without altering the DNA sequence, once surprising, is the stuff of textbooks. The phenomenon, epigenetics, has\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2985,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2985","url_meta":{"origin":1876,"position":1},"title":"How to make an organelle in eukaryotes","author":"biochemistry","date":"March 29, 2019","format":false,"excerpt":"\u00a0 \u00a0 A key step in the evolution of complex organisms like eukaryotes was the organization of specific tasks into organelles. Reinkemeier\u00a0et al.\u00a0designed an artificial, membraneless organelle into mammalian cells to perform orthogonal translation. In response to a specific codon in a selected messenger RNA, ribosomes confined to this organelle\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1495,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1495","url_meta":{"origin":1876,"position":2},"title":"Protein complexes assemble as they are being made","author":"biochemistry","date":"August 30, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 An investigation finds that most protein complexes in yeast cells assemble before the subunits have fully formed. This mechanism might prevent the formation of toxic protein aggregates. \u00a0 \u00a0 Most cellular processes are carried out by proteins, which generally assemble into heteromeric complexes \u2014 those\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4919,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4919","url_meta":{"origin":1876,"position":3},"title":"Gene expression regulated by RNA stability","author":"biochemistry","date":"January 7, 2020","format":false,"excerpt":"\u00a0 \u00a0 One of the first discoveries of gene expression mediated by controlling messenger RNA (mRNA) stability is autoregulation of tubulin synthesis. In this regulatory process, the concentration of tubulin subunits modulates the stability of the mRNAs from which they are translated (1,\u00a02). In the 1980s it was found that\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4959,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4959","url_meta":{"origin":1876,"position":4},"title":"Four ways researchers are responding to the COVID-19 outbreak & \ucf54\ub85c\ub098 \ubc31\uc2e0\uc740 \uc65c \ubd80\uc791\uc6a9\uc774 \uac15\ud55c\uac00 & mRNA, \uc774\uc81c \ucf54\ub85c\ub098 \ub118\uc5b4 \uc554\uc815\ubcf5 \uafc8\uafbc\ub2e4\u2026\uad6d\ub0b4 \ubc14\uc774\uc624\ud14d ‘\uc774\uacf3’ \uc8fc\ubaa9 &&","author":"biochemistry","date":"February 24, 2020","format":false,"excerpt":"\u00a0 \u00a0 How did researchers react so quickly to the SARS-CoV-2 epidemic? Nature Medicine has asked some key experts. \u00a0 \u201cThe reason we were able to go so fast this time is we've been working on solutions for coronaviruses for several years now,\u201d says Barney Graham, Deputy Director of the\u2026","rel":"","context":"In "Essays on Science"","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4784,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4784","url_meta":{"origin":1876,"position":5},"title":"Beyond the genome: RNA control of stem cells","author":"biochemistry","date":"November 8, 2019","format":false,"excerpt":"\u00a0 \u00a0 Tissue-resident stem cells are important for maintaining proper organ and tissue function throughout the lifetime of mammals. Although some types of stem cells constantly proliferate and give rise to committed progeny, such as intestine and skin, others reside mainly in a quiescent (noncycling) state, such as skeletal muscle.\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_sharing_enabled":false,"jetpack_shortlink":"https:\/\/wp.me\/p9Xo1j-ug","_links":{"self":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/1876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1876"}],"version-history":[{"count":5,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/1876\/revisions"}],"predecessor-version":[{"id":4258,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/1876\/revisions\/4258"}],"wp:attachment":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1876"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1876"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}