{"id":1865,"date":"2018-09-25T14:39:50","date_gmt":"2018-09-25T05:39:50","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=1865"},"modified":"2023-07-05T15:12:39","modified_gmt":"2023-07-05T06:12:39","slug":"receptor-dynamics-predict-drug-effects","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1865","title":{"rendered":"Receptor dynamics predict drug effects"},"content":{"rendered":"

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Science\u00a0<\/cite>\u00a021 Sep 2018:
\nVol. 361, Issue 6408, pp. 1211-1213
\nDOI: 10.1126\/science.361.6408.1211-r<\/p>\n

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(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n

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The effect of a drug on a G protein\u2013coupled receptor (GPCR) can be determined by monitoring the downstream effects of that receptor, but not for GPCRs whose signaling pathways are unclear. Yanagawa\u00a0et al.<\/em>\u00a0performed single-molecule imaging of different GPCRs in the plasma membrane. They found that the diffusion dynamics correlated with whether the interacting drug activated or inhibited the receptor, resulted in the coupling of GPCRs to G proteins, or induced receptor endocytosis. Thus, analyzing the diffusion of a GPCR provides an estimate for the effect of a candidate drug.<\/p>\n

Sci. Signal.<\/em>\u00a011<\/strong>, eaao1917 (2018).<\/p>\n

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    Science\u00a0\u00a021 Sep 2018: Vol. 361, Issue 6408, pp. 1211-1213 DOI: 10.1126\/science.361.6408.1211-r   (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~)   The effect of a drug on a(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[33,29,30],"tags":[],"class_list":["post-1865","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","category-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":4122,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4122","url_meta":{"origin":1865,"position":0},"title":"Countering opioid side effects","author":"biochemistry","date":"September 23, 2019","format":false,"excerpt":"\u00a0 \u00a0 The toll from opioid overdose in the United States now exceeds 45,000 deaths per year. 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