{"id":1816,"date":"2018-09-23T16:12:46","date_gmt":"2018-09-23T07:12:46","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=1816"},"modified":"2019-10-14T14:06:37","modified_gmt":"2019-10-14T05:06:37","slug":"a-core-problem-in-nuclear-assembly","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1816","title":{"rendered":"A core problem in nuclear assembly"},"content":{"rendered":"

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Chromosomes can exist outside the nucleus in rupture-prone structures called micronuclei. It emerges that micronuclei are fragile because their outer layer lacks some nuclear-envelope components.<\/h5>\n

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The genome sequencing of some cancer cells revealed the occurrence of large-scale DNA rearrangements that are characteristic of a single catastrophic event1<\/a><\/sup>. This type of genetic abnormality is termed chromothripsis. It occurs in many types of human cancer, and is thought to drive tumour formation2<\/a><\/sup>. Chromothripsis can arise as a result of cell division if individual chromosomes do not join the other chromosomes within the newly formed nuclei but instead form rupture-prone structures called micronuclei3<\/a><\/sup>,<\/sup>4<\/a><\/sup>.\u00a0Writing in\u00a0Nature<\/i><\/a>, Liu\u00a0et al<\/i>.5<\/a><\/sup>\u00a0report that the nuclear-envelope structure that encloses a micronucleus lacks some of the components of the nuclear envelope that surrounds a nucleus. They propose a mechanism for how this might occur, and how it might account for micronuclear fragility.<\/p>\n

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