{"id":1811,"date":"2018-09-23T16:05:36","date_gmt":"2018-09-23T07:05:36","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=1811"},"modified":"2019-10-15T19:07:28","modified_gmt":"2019-10-15T10:07:28","slug":"the-multitasking-cell-that-can-build-the-parts-of-a-human-skeleton","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1811","title":{"rendered":"The multitasking cell that can build the parts of a human skeleton"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>(<a href=\"https:\/\/www.nature.com\/articles\/d41586-018-06743-0?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29\">\uc6d0\ubb38<\/a>)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h5>Cells sprout into bits of human bone when implanted in mice.<\/h5>\n<p>&nbsp;<\/p>\n<div class=\"article-item__body serif\">\n<p>Human stem cells that give rise to bone, cartilage and other skeletal tissues have been isolated for the first time, opening the door to new treatments for debilitating conditions such as osteoarthritis.<\/p>\n<p>Stem cells mature into many types of tissue. Previous research has identified mouse stem cells that develop into a range of skeletal tissues, but the human equivalent has proved elusive.<\/p>\n<p>Charles Chan and Michael Longaker at Stanford Medicine in California and their colleagues discovered human cells that showed the same pattern of gene activity as mouse skeletal stem cells. A subset of these human cells successfully generated human bone, cartilage and bone-marrow cells after being transplanted into mice.<\/p>\n<p>To test whether the stem cells would replenish bone after an injury, the researchers fractured human bone that they had grafted into mice. In response, the human skeletal stem cells proliferated more at fracture sites than at stretches of unbroken bone.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div class=\"article__sidebar\">\n<p class=\"article-item__original-research strong\"><a class=\"serif\" href=\"https:\/\/doi.org\/10.1016\/j.cell.2018.07.029\" data-track=\"click\" data-track-label=\"original research\"><i>Cell<\/i>\u00a0(2018)<\/a><\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; (\uc6d0\ubb38) &nbsp; &nbsp; Cells sprout into bits of human bone when implanted in mice. &nbsp; Human stem cells that give rise to bone,<a href=\"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1811\" class=\"more-link\">(more&#8230;)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[33,29,30],"tags":[],"class_list":["post-1811","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","category-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":4784,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4784","url_meta":{"origin":1811,"position":0},"title":"Beyond the genome: RNA control of stem cells","author":"biochemistry","date":"November 8, 2019","format":false,"excerpt":"\u00a0 \u00a0 Tissue-resident stem cells are important for maintaining proper organ and tissue function throughout the lifetime of mammals. Although some types of stem cells constantly proliferate and give rise to committed progeny, such as intestine and skin, others reside mainly in a quiescent (noncycling) state, such as skeletal muscle.\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2952,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2952","url_meta":{"origin":1811,"position":1},"title":"The CRISPR \ufefffix that could combat inherited blood disorders","author":"biochemistry","date":"March 27, 2019","format":false,"excerpt":"\u00a0 Researchers have finally identified a reliable way to edit the genes of blood stem cells. \u00a0 The elongated red blood cells of people with sickle-cell disease can block small blood vessels, reducing the flow of oxygen to nearby tissues. Credit: Eye of Science\/SPL \u00a0 \u00a0 \u00a0 An enhanced version\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4084,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4084","url_meta":{"origin":1811,"position":2},"title":"Scientists use gene-edited stem cells to treat HIV \u2014 with mixed success","author":"biochemistry","date":"September 17, 2019","format":false,"excerpt":"\u00a0 \u00a0 Modified cells survived 19 months after transplant into an HIV-positive man in China, but the dose was not enough to reduce his viral load. \u00a0 \u00a0 HIV destroys the body's defences by attacking immune cells.\u00a0Credit: Steve Gschmeissner\/Science Photo Library \u00a0 \u00a0 For the first time, researchers have used\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3524,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3524","url_meta":{"origin":1811,"position":3},"title":"Stem-cell and genetic therapies make a healthy marriage","author":"biochemistry","date":"May 16, 2019","format":false,"excerpt":"\u00a0 \u00a0 This scientific partnership could fight everything from blood diseases to HIV. \u00a0 A culture from human tissue showing neurons derived from stem cells.Credit: Daniel Schroen\/Cell Applications Inc\/SPL \u00a0 \u00a0 Aside from a 20-second exposure to the outside world at birth, David Vetter spent his entire life cocooned in\u2026","rel":"","context":"In &quot;Essays on Science&quot;","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4849,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4849","url_meta":{"origin":1811,"position":4},"title":"Modeling the early development of a primate embryo","author":"biochemistry","date":"November 15, 2019","format":false,"excerpt":"\u00a0 \u00a0 Because mammalian embryos develop inside the uterus after implantation, they are practically inaccessible for direct observation and experimental analysis of the developmental process. To visualize and study the development of post-implantation embryos, it is necessary to develop a technology that maintains the viability and growth of embryos ex\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3933,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3933","url_meta":{"origin":1811,"position":5},"title":"Flower power as human cancer cells compete with normal cells","author":"biochemistry","date":"July 27, 2019","format":false,"excerpt":"\u00a0 \u00a0 Cells compete for survival during development. It emerges that mammalian cells on a path to form a tumour express specific versions of the protein Flower when they vie for survival with surrounding normal cells. \u00a0 \u00a0 In multicellular organisms, cells usually communicate with each other in a peaceful\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_sharing_enabled":false,"jetpack_shortlink":"https:\/\/wp.me\/p9Xo1j-td","_links":{"self":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/1811","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1811"}],"version-history":[{"count":2,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/1811\/revisions"}],"predecessor-version":[{"id":4402,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/1811\/revisions\/4402"}],"wp:attachment":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1811"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1811"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1811"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}