{"id":1754,"date":"2018-09-19T11:21:45","date_gmt":"2018-09-19T02:21:45","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=1754"},"modified":"2019-10-21T10:33:10","modified_gmt":"2019-10-21T01:33:10","slug":"%ea%b1%b4%ea%b0%95%ed%95%98%eb%8b%a4%eb%a9%b4-%ec%95%84%ec%8a%a4%ed%94%bc%eb%a6%b0-%eb%a8%b9%ec%a7%80%eb%a7%88%eb%9d%bc","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1754","title":{"rendered":"&#8220;\uac74\uac15\ud558\ub2e4\uba74 \uc544\uc2a4\ud53c\ub9b0 \uba39\uc9c0\ub9c8\ub77c&#8221; &#038; \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\uc131 \ud56d\uc5fc\uc81c(NSAIDs) \uc774\uc57c\uae30"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>(<a href=\"http:\/\/dongascience.donga.com\/news\/view\/23990\">\uc6d0\ubb38<\/a>)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"end_photo_org\"><img decoding=\"async\" src=\"https:\/\/imgnews.pstatic.net\/image\/584\/2018\/09\/18\/0000001745_001_20180918143110405.jpg?type=w647\" \/><\/span><\/p>\n<p><span class=\"end_photo_org\"><em class=\"img_desc\"><span class=\"word_dic en\">GIB<\/span>\u00a0\uc81c\uacf5<\/em><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\uc544\uc2a4\ud53c\ub9b0\uc740 \ud608\uad00\uc5d0 \ubb3c\uc9c8\uc774 \uc313\uc774\ub294 \uac83\uc744 \ub9c9\ub294\ub2e4\uace0 \uc54c\ub824\uc838\uc654\ub2e4. \uc774\ub7f0 \uc774\uc720\ub85c \uac74\uac15\ud55c \uc0ac\ub78c \uc911\uc5d0\uc11c\ub3c4 \uc2ec\uc7a5 \ubd80\ub2f4\uc744 \uc904\uc77c \ubaa9\uc801\uc73c\ub85c \uc18c\ub7c9\uc758 \uc544\uc2a4\ud53c\ub9b0\uc744 \ub9e4\uc77c \uba39\ub294 \uc774\ub4e4\uc774 \uc788\ub2e4. \ud558\uc9c0\ub9cc \ub9e4\uc77c \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud574\ub3c4 \uc2ec\uc7a5\uc9c8\ud658 \ub4f1\uc758 \uc9c8\ubcd1 \uc608\ubc29 \ud6a8\uacfc\ub294 \uae30\ub300\ud558\uae30 \uc5b4\ub835\ub2e4\ub294 \uc5f0\uad6c\uac00 \ub098\uc654\ub2e4.<\/p>\n<p>\uc601\uad6d \uc77c\uac04 \uac00\ub514\uc5b8\uc740 17\uc77c(\ud604\uc9c0 \uc2dc\uac04) \uc874 \ub9e5\ub124\uc77c \ud638\uc8fc \ubaa8\ub098\uc26c\ub300 \uc5ed\ud559\ubc0f\uc608\ubc29\uc758\ud559\uacfc \uad50\uc218 \uc5f0\uad6c\uc9c4\uc774 \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\ub294 \uc0ac\ub78c\uc774 \uadf8\ub807\uc9c0 \uc54a\uc740 \uc0ac\ub78c\ubcf4\ub2e4 \uc624\ud788\ub824 \uc2ec\uc7a5 \uc9c8\ud658\uc744 \uc553\uc744 \ud655\ub960\uc774 \ub192\uc744 \ubfd0\uc544\ub2c8\ub77c \uc218\uba85\ub3c4 \ub354 \uc9e7\ub2e4\ub294 \uc5f0\uad6c\uacb0\uacfc\ub97c \ud559\uc220\uc9c0 \u2018\ub274 \uc789\uae00\ub79c\ub4dc \uc758\ud559 \uc800\ub110\u2019\uc5d0 \ubc1c\ud45c\ud588\ub2e4\uace0 \uc804\ud588\ub2e4.<\/p>\n<p>\uc5f0\uad6c\uc9c4\uc740 \ud638\uc8fc\uc640 \ubbf8\uad6d\uc5d0\uc11c \uac74\uac15\uc0c1\uc758 \ubb38\uc81c\uac00 \uc5c6\ub294 \uc57d 70\uc138 \uc774\uc0c1\uc758 \uc778\uad6c 1\ub9cc 9000\uba85\uc744 \ubaa8\uc740 \ub2e4\uc74c, \uc808\ubc18\uc529 \ub450 \uadf8\ub8f9\uc73c\ub85c \ub098\ub234\ub2e4. \ud55c \uadf8\ub8f9\uc740 \ub9e4\uc77c 100\ubc00\ub9ac\uadf8\ub7a8(<span class=\"word_dic en\">mg<\/span>)\uc758 \uc544\uc2a4\ud53c\ub9b0\uc744, \ub098\uba38\uc9c0 \uadf8\ub8f9\uc740 \uac00\uc9dc \uc57d\uc744 \uba39\ub294 \uc2e4\ud5d8\uc744 \uc124\uacc4\ud574 5\ub144\uac04 \uc9c4\ud589\ud558\uba74\uc11c \uc9c8\ubcd1 \ubc1c\uc0dd \ud604\ud669\uacfc \uc0dd\uc874 \uc5ec\ubd80\ub97c \ucd94\uc801\ud588\ub2e4.<\/p>\n<p>\uadf8 \uacb0\uacfc \ub450 \uadf8\ub8f9 \uc0ac\uc774 \uc9c8\ubcd1 \ubc1c\ubcd1\uc728\uc740 \ud070 \ucc28\uc774\uac00 \uc5c6\ub294 \uac83\uc744 \ud655\uc778\ud588\ub2e4. \uc544\uc2a4\ud53c\ub9b0 \ubcf5\uc6a9\uadf8\ub8f9\uc5d0\uc11c \uc2ec\ud55c \uc2ec\uc7a5\ub9c8\ube44\ub098 \ub0b4\uc7a5\uc9c8\ud658\uc744 \uc553\uc740 \ube44\uc728\uc740 3.8%\ub85c \ubcf5\uc6a9\ud558\uc9c0 \uc54a\uc740 \uadf8\ub8f9\uc758 \ubc1c\ubcd1\uc728(2.7%)\ubcf4\ub2e4 \ub418\ub808 \ub354 \ub192\uac8c \ub098\ud0c0\ub0ac\ub2e4. \uac74\uac15\ud55c \uc0ac\ub78c\uc774 \uc544\uc2a4\ud53c\ub9b0\ub97c \ubcf5\uc6a9\ud55c\ub2e4\uace0\ud574\ub3c4 \uc2ec\ud608\uad00 \uc9c8\ubcd1\uc744 \uc608\ubc29\ud560 \uc218 \uc5c6\ub2e4\ub294 \ub73b\uc774\ub2e4. \ub610 \uc5f0\uad6c\uc9c4\uc740 \uce58\ub9e4\ub098 \ub2e4\ub978 \uc6b4\ub3d9 \uc7a5\uc560 \ubc1c\ubcd1\ub960\ub3c4 \ud568\uaed8 \uc870\uc0ac\ud588\uc9c0\ub9cc \uc544\uc2a4\ud53c\ub9b0 \ubcf5\uc6a9 \uc2b5\uad00\uacfc\uc758 \uc5f0\uad00\uc131\uc740 \uc804\ud600 \ucc3e\uc9c0 \ubabb\ud588\ub2e4.<\/p>\n<p>\uc874 \ub9e5\ub124\uc77c \ubaa8\ub098\uc26c\ub300 \uc5ed\ud559\ubc0f\uc608\ubc29\uc758\ud559\uacfc \uad50\uc218\ub294 &#8220;70\uc138 \uc548\ud30d\uc758 \ub098\uc774\uae4c\uc9c0 \uac74\uac15\uc744 \uc720\uc9c0\ud558\ub294 \uc778\uad6c \uc911 \ubcc4 \uc774\uc720\uc5c6\uc774 \ub9e4\uc77c \uc18c\ub7c9\uc758 \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\ub294 \uc0ac\ub78c\uc774 \ub9ce\ub2e4&#8221;\uba70 &#8220;(\uc774\ubc88 \uc5f0\uad6c\uc5d0\uc11c) \uadf8\ub7f4 \uc774\uc720\uac00 \uc5c6\ub2e4\ub294 \uac8c \ud655\uc778\ub41c \uac83&#8221;\uc774\ub77c\uace0 \uc124\uba85\ud588\ub2e4. \ud2b9\ud788 \uc5f0\uad6c\uc9c4\uc740 \uc2e4\ud5d8\ub3c4 \uc911 \uc228\uc9c4 \uc0ac\ub78c \ube44\uc728\uae4c\uc9c0 \uc544\uc2a4\ud53c\ub9b0 \ubcf5\uc6a9\uadf8\ub8f9(5.9%)\uc774 \uba39\uc9c0\uc54a\uc740 \uadf8\ub8f9(5.2%)\ubcf4\ub2e4 \ub192\uac8c \ub098\uc624\uba74\uc11c \uc9c0\ubcd1\uc73c\ub85c \uc778\ud574 \ubcc4\ub3c4\ub85c \ubcd1\uc6d0\uc5d0 \ucc98\ubc29\uc744 \ubc1b\uc740 \uac83\uc774 \uc544\ub2c8\ub77c\uba74 \uc544\uc2a4\ud53c\ub9b0\uc744 \uba39\uc744 \ud544\uc694\uac00 \uc5c6\ub2e4\uace0 \uc8fc\uc7a5\ud588\ub2e4.<\/p>\n<p>\uc774\uc5d0 \ud53c\ud130 \ub85c\uc2a4\uc6f0 \uc601\uad6d \uc625\uc2a4\ud37c\ub4dc\ub300 \uc2e0\uacbd\ud559\uacfc \uad50\uc218\ub3c4 \u201c\ub098\uc774\uac00 \ub4e4\uc5b4\ub3c4 \uc815\uc0c1\uc801\uc778 \uac74\uac15\uc0c1\ud0dc\ub97c \uc720\uc9c0\ud55c\ub2e4\uba74 \uc544\uc2a4\ud53c\ub9b0\uc744 \ucc59\uaca8 \uba39\uc744 \ud544\uc694\uac00 \uc804\ud600 \uc5c6\ub2e4\u201d\uba70 \u201c\uc758\ud559\uc801\uc73c\ub85c \uc5f0\uad00\uc131\uc774 \ub9e4\uc6b0 \uc801\uc740 \uc598\uae30\ub85c, \uc774 \uc5f0\uad6c\uac00 \ubc14\ub85c \uadf8 \uc99d\uac70\ub2e4\u201d\ub77c\uace0 \ub9d0\ud588\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h4 class=\"tit_view\">\uba39\ub290\ub0d0 \ub9c8\ub290\ub0d0, \uc758\uc0ac\ub4e4\ub3c4 \uc544\uc2a4\ud53c\ub9b0 \ub51c\ub808\ub9c8<\/h4>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong class=\"summary_view\" data-translation=\"\">&#8220;\uc2ec\uc7a5\ubcd1 \uc608\ubc29 \ud6a8\uacfc&#8221; vs &#8220;\ub1cc\ucd9c\ud608 \ubd80\uc791\uc6a9&#8221;.. \uc800\uc6a9\ub7c9 \uc7a5\uae30\ubcf5\uc6a9 \ub193\uace0 \ud33d\ud33d\ud55c \ub17c\uc7c1<\/strong><\/p>\n<p>&nbsp;<\/p>\n<div id=\"harmonyContainer\" class=\"article_view\" data-translation-body=\"\">\n<section>A\uc528\ub294 72\uc138 \ub0a8\uc790\ub85c 5\ub144 \uc804\ubd80\ud130 \uc800\uc6a9\ub7c9(\ud558\ub8e8 100\u338e \uc774\ud558) \uc544\uc2a4\ud53c\ub9b0\uc744 \ub9e4\uc77c \ubcf5\uc6a9\ud558\uace0 \uc788\ub2e4. \uadf8\uc5d0\uac8c\ub294 \uace0\ud608\uc555\uacfc \uace0\uc9c0\ud608\uc99d\uc774 \uc788\ub2e4. \ud608\uc555\uc57d \ud55c \uac1c\ub97c \uba39\uace0 \uc788\uc73c\uba70, \uc2a4\ud0c0\ud2f4 \uc81c\uc81c(\ucf5c\ub808\uc2a4\ud14c\ub864 \uac15\ud558\uc81c)\ub3c4 \ubcf5\uc6a9 \uc911\uc774\ub2e4. \uccb4\uc9c8\ub7c9\uc9c0\uc218(BMI)\uac00 30\uc73c\ub85c \ube44\ub9cc \uc0c1\ud0dc\ub2e4. \uadf8\ub807\uc9c0\ub9cc \ub2f4\ubc30\ub97c \ud53c\uc6cc \ubcf8 \uc801\uc774 \uc5c6\uace0, \uc220\ub3c4 \uc8fc\ub9d0\uc5d0 \ub9e5\uc8fc \ud55c\ub450 \uc794\ub9cc \ub9c8\uc2e0\ub2e4. \uc77c\uc8fc\uc77c\uc5d0 \uc138 \ubc88 \uc815\ub3c4 \uc544\ub0b4\uc640 30\ubd84\uc529 \uac77\ub294\ub2e4. \uac00\uc871 \uc911\uc5d0 \uc2ec\uadfc\uacbd\uc0c9\uc99d \ud658\uc790\ub294 \uc5c6\uc9c0\ub9cc, \uc544\ubc84\uc9c0\uac00 \ub1cc\uacbd\uc0c9\uc73c\ub85c \uace0\uc0dd\ud588\ub2e4. \ud608\uc555\uc740 \uc815\uc0c1\uc73c\ub85c \uc870\uc808\ub418\uace0 \uc788\ub2e4.A\uc528\uac00 \ud3c9\uc18c \ub2e4\ub2c8\ub358 \ub3d9\ub124 \ubcd1\uc6d0\uc744 \ucc3e\uc544\uac00 &#8220;\uc758\uc0ac \uc591\ubc18, \uc694\uc998 \uc800\uc6a9\ub7c9 \uc544\uc2a4\ud53c\ub9b0\uc774 \uc2ec\uc7a5\ubcd1 \uc608\ubc29 \ud6a8\uacfc\ub294 \uc5c6\uace0 \ub418\ub808 \ud574\ub97c \uc904 \uc218 \uc788\ub2e4\ub294 \ub274\uc2a4\uac00 \ub098\uc624\ub358\ub370 \uc544\uc2a4\ud53c\ub9b0 \uacc4\uc18d \ubcf5\uc6a9\ud574\ub3c4 \ub418\ub098?&#8221;\ub77c\uace0 \ubb3b\ub294\ub2e4\uba74 \uc758\uc0ac\uc758 \ub2f5\ubcc0\uc740 \uc5b4\ub5a8\uae4c.<\/p>\n<p>16\uc77c \uc138\uacc4 \ucd5c\uace0 \uc758\ud559\ud559\uc220\uc9c0 &#8216;\ub274\uc789\uae00\ub79c\ub4dc \uc800\ub110 \uc624\ube0c \uba54\ub514\uc2e0(NEJM)&#8217;\uc774 \uc758\uc0ac\ub4e4\uc5d0\uac8c &#8220;\ub2f9\uc2e0\uc774 \uc774\ub7f0 \ud658\uc790\ub97c \ub9cc\ub098\uba74 \uc5b4\ub5bb\uac8c \ud558\uaca0\ub290\ub0d0&#8221;\ub294 \uc9c8\ubb38\uc744 \ub358\uc84c\ub2e4. \uc5ec\ub860\uc870\uc0ac \uacb0\uacfc\ub294 &#8216;\ubcf5\uc6a9\uc744 \uc911\ub2e8\ud574\uc57c \ud55c\ub2e4&#8217;\uc640 &#8216;\uacc4\uc18d \uba39\uc5b4\uc57c \ud55c\ub2e4&#8217;\ub85c \ud33d\ud33d\ud558\uac8c \ub098\ub258\uc5c8\ub2e4. \uc911\ub2e8\ud30c\uac00 51%, \uc9c0\uc18d\ud30c\ub294 48%\ub85c, \uc624\ucc28 \ubc94\uc704 \ub0b4 \uc811\uc804\uc774\ub2e4. \ubb34\uc870\uac74 \ubcf5\uc6a9\uc744 \uc911\ub2e8\ud558\ub294 \uac8c \uc544\ub2c8\ub77c \ucc98\ud55c \uc0c1\ud669\uc5d0 \ub530\ub77c \ub2e4\ub974\ub2e4\ub294 \uc758\ubbf8\ub2e4. \ucd5c\uadfc \uc2ec\uc7a5\ubcd1 \uc608\ubc29\uc6a9 \uc544\uc2a4\ud53c\ub9b0 \ubb34\uc6a9\ub860\uc774 \ub098\uc624\uba74\uc11c \ubbf8\uad6d\uc740 \ubb3c\ub860 \uad6d\ub0b4 \ubcd1\u00b7\uc758\uc6d0 \uc9c4\ub8cc\uc2e4\uc5d0\uc11c\ub3c4 \uc800\uc6a9\ub7c9 \uc544\uc2a4\ud53c\ub9b0\uc744 \uba39\ub358 \ud658\uc790\ub4e4\uc758 \ubb38\uc758\uac00 \uc3df\uc544\uc9c0\uace0 \uc788\ub2e4.<\/p>\n<p>\u25c7<strong>\uac74\uac15\ud55c \uc0ac\ub78c\uc740 \ubcf5\uc6a9\ud560 \ud544\uc694 \uc5c6\uc5b4<\/strong><\/p>\n<p>\uc800\uc6a9\ub7c9 \uc544\uc2a4\ud53c\ub9b0 \uc694\ubc95\uc740 \uc2ec\uc7a5\ubcd1 \uc608\ubc29 \ud6a8\uacfc\uac00 \uc788\ub2e4\uace0 \uc54c\ub824\uc9c0\uba74\uc11c 1990\ub144\ub300\ubd80\ud130 \uc720\ud589\ucc98\ub7fc \ubc88\uc84c\ub2e4. \uc544\uc2a4\ud53c\ub9b0 \uc131\ubd84\uc774 \ud608\uc561 \ub0b4 \ud608\uc18c\ud310\uc758 \uc751\uc9d1\uc744 \ub9c9\uc544\uc11c \ud53c\ub5a1(\ud608\uc804) \uc0dd\uc131\uc744 \uc904\uc774\uae30 \ub54c\ubb38\uc774\ub2e4. \uc2ec\uadfc\uacbd\uc0c9\uc99d\uc774\ub098 \ub1cc\uacbd\uc0c9\uc740 \uc8fc\ub85c \ud608\uc804\uc774 \ub3d9\ub9e5\uc744 \ub9c9\uc544 \uc0dd\uae34\ub2e4.<\/p>\n<figure class=\"figure_frm origin_fig\">\n<p class=\"link_figure\"><img decoding=\"async\" class=\"thumb_g_article\" src=\"https:\/\/img3.daumcdn.net\/thumb\/R430x0.q70\/?fname=https:\/\/t1.daumcdn.net\/news\/201905\/17\/chosun\/20190517094703380zkxf.jpg\" width=\"430\" height=\"auto\" \/><\/p>\n<p class=\"link_figure\"><a class=\"ico_view link_photo #body #photo #exted\" href=\"https:\/\/news.v.daum.net\/v\/photo\/20190517030901995?url=https:\/\/t1.daumcdn.net\/news\/201905\/17\/chosun\/20190517094703380zkxf.jpg\" data-no-translation=\"\">\uc774\ubbf8\uc9c0 \ud06c\uac8c \ubcf4\uae30<\/a><\/p>\n<\/figure>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\uc804 \uc138\uacc4 100\uc5ec \uad6d\uc5d0 \uc800\uc6a9\ub7c9 \uc804\uc6a9 \uc544\uc2a4\ud53c\ub9b0\uc774 \ubcf4\uae09\ub410\ub2e4. \ud2b8\ub7fc\ud504 \ubbf8\uad6d \ub300\ud1b5\ub839\ub3c4 \ub9e4\uc77c \uba39\ub294\ub2e4. \uadf8\ub7f0\ub370 2010\ub144\ubd80\ud130 \uc2ec\uc7a5\ubcd1 \ubc1c\uc0dd \uc6b0\ub824\uac00 \uc5c6\ub294 \uc0ac\ub78c\uc740 \uc544\uc2a4\ud53c\ub9b0\uc744 \uba39\uc5b4\ub3c4 \uc2ec\ud608\uad00\uc9c8\ud658 \uc608\ubc29\uc5d0 \ud6a8\uacfc\uac00 \uc5c6\uace0, \ub418\ub808 \ub1cc\ucd9c\ud608 \uc704\ud5d8\uc744 \ub192\uc778\ub2e4\ub294 \uc5f0\uad6c\ub4e4\uc774 \uc787\ub530\ub77c \ub098\uc654\ub2e4. \uae09\uae30\uc57c \uc9c0\ub09c 3\uc6d4 \ubbf8\uad6d\uc2ec\uc7a5\ud559\ud68c\ub294 \uac74\uac15\ud55c \uc0ac\ub78c\uc740 \uc608\ubc29\uc6a9 \uc544\uc2a4\ud53c\ub9b0\uc744 \uba39\uc744 \ud544\uc694\uac00 \uc5c6\ub2e4\uace0 \uacb0\ub860 \ub0b4\ub838\ub2e4.<\/p>\n<p>\u25c7<strong>\uc2ec\uadfc\uacbd\uc0c9\uc99d \uc704\ud5d8 \ub192\uc73c\uba74 \ubcf5\uc6a9\ud574\uc57c<\/strong><\/p>\n<p>\ubb38\uc81c\ub294 A\uc528\ucc98\ub7fc \uc2ec\uc7a5\ubcd1 \ubc1c\uc0dd \uc6b0\ub824\uac00 \uc788\ub294 \uacbd\uc6b0\ub2e4. \ub300\ud55c\uc2ec\uc7a5\ud559\ud68c\uc9c0 \uc7a5\uc591\uc218(\uc5f0\uc138\ub300\uc758\ub300 \uc2ec\uc7a5\ub0b4\uacfc) \ud3b8\uc9d1\uc7a5\uc740 &#8220;\ud604\uc7ac \uc2ec\uc7a5\ubcd1\uc774 \uc5c6\ub354\ub77c\ub3c4 10\ub144 \ub0b4 \uc2ec\uadfc\uacbd\uc0c9\uc99d \ubc1c\uc0dd \uc704\ud5d8\uc774 10~20% \uc774\uc0c1\uc73c\ub85c \ub098\uc624\ub294 \uc0ac\ub78c\uc740 \uc608\ubc29 \ubaa9\uc801\uc73c\ub85c \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\ub294 \uac8c \uc88b\ub2e4&#8221;\uace0 \ub9d0\ud588\ub2e4. \uc2ec\uadfc\uacbd\uc0c9\uc99d \uc704\ud5d8 \uc608\uce21\uc740 \uc778\ud130\ub137\uc0c1\uc5d0\uc11c \uc77c\ubc18\uc778\ub3c4 \ud560 \uc218 \uc788\ub2e4. \uac80\uc0c9\ucc3d\uc5d0 \uc601\uc5b4\ub85c &#8216;\ud504\ub798\ubc0d\ud584 \ub9ac\uc2a4\ud06c \uc2a4\ucf54\uc5b4 \uacc4\uc0b0\uae30(Framingham risk score calculator)&#8217;\ub97c \uce58\uace0, \uc785\ub825 \uce78\uc5d0 \ub098\uc774\u00b7\uc131\ubcc4\u00b7\ucd1d \ucf5c\ub808\uc2a4\ud14c\ub864 \uc218\uce58(mg\/dL)\u00b7HDL \ucf5c\ub808\uc2a4\ud14c\ub864\u00b7\uc218\ucd95\uae30 \ud608\uc555(mmHg)\u00b7\ud608\uc555\uc57d \ubcf5\uc6a9 \uc5ec\ubd80\u00b7\ud761\uc5f0 \uc5ec\ubd80\ub97c \ub123\uc73c\uba74 \ub41c\ub2e4. 50\ub300 \uc911\ubc18 \ub0a8\uc790\uace0, \ucf5c\ub808\uc2a4\ud14c\ub864\uc774 \uc815\uc0c1\ubcf4\ub2e4 \uc57d\uac04 \ub192\uace0, \ud608\uc555\uc57d\uc744 \uba39\uace0 \uc788\ub2e4\uba74, \uc704\ud5d8\ub960\uc740 10% \uc548\ud30e\uc73c\ub85c \ub098\uc628\ub2e4. \uac74\uac15 \uc9c0\ud45c\uac00 \ub098\uc060\uc218\ub85d \uc218\uce58\uac00 \uc62c\ub77c\uac00 \uc544\uc2a4\ud53c\ub9b0 \ubcf5\uc6a9 \ub300\uc0c1\uc790\uac00 \ub41c\ub2e4.<\/p>\n<p>\uc800\uc6a9\ub7c9 \uc544\uc2a4\ud53c\ub9b0\uc774 \ud53c\ub97c \ubb3d\uac8c \ud574 \uc2ec\uadfc\uacbd\uc0c9\uc744 \uc904\uc774\ub294 \ucabd\uc778\uc9c0, \uc544\ub2c8\uba74 \ucd9c\ud608 \uc704\ud5d8\uc774 \ucee4\uc9c0\ub294 \ucabd\uc778\uc9c0\uc5d0 \ub530\ub77c \uc120\ud0dd\uc774 \ub2ec\ub77c\uc9c4\ub2e4. \uace0\ub839\uc790\ub294 \ud608\uad00\uc774 \uc57d\ud574\uc838 \uc788\uae30 \ub54c\ubb38\uc5d0 \ucd9c\ud608 \uc704\ud5d8\uc774 \ub192\uc544 \uc77c\ubc18\uc801\uc73c\ub85c \ubcf5\uc6a9\uc744 \uad8c\uc7a5\ud558\uc9c0 \uc54a\ub294\ub2e4. \ub300\ud55c\uc2ec\ub1cc\ud608\uad00\uc9c8\ud658\uc608\ubc29\ud559\ud68c \ubc15\ucc3d\uaddc(\uace0\ub824\ub300\uc758\ub300 \uc2ec\uc7a5\ub0b4\uacfc) \uc774\uc0ac\ub294 &#8220;\uc544\uc2a4\ud53c\ub9b0\uc744 \uba39\uace0 \uc788\ub294\ub370 \uba4d\uc774 \uc790\uc8fc \ub4e4\uac70\ub098, \uc591\uce58\uc9c8\ud560 \ub54c \uc787\ubab8\uc5d0\uc11c \ud53c\uac00 \ub098\ub294 \ub4f1 \ucd9c\ud608 \uc9d5\uc870\uac00 \uc788\uc73c\uba74 \ubcf5\uc6a9\ud558\uc9c0 \uc54a\ub294 \uac8c \uc88b\ub2e4&#8221;\uace0 \ub9d0\ud588\ub2e4. &#8220;\uc2ec\uc7a5\ubcd1 \ubc1c\ubcd1 \uc704\ud5d8 \uc778\uc790\uac00 \ub9ce\uc740 \uc0c1\ud0dc\uc5d0\uc11c \uba87 \ub144\uc9f8 \ubcf5\uc6a9\ud588\uace0, \ucd9c\ud608 \uc9d5\uc870 \uc5c6\uc774 \uc798 \uba39\uc5b4 \uc654\ub2e4\uba74 \uad73\uc774 \uc544\uc2a4\ud53c\ub9b0\uc740 \uc911\ub2e8\ud560 \ud544\uc694\ub294 \uc5c6\ub2e4&#8221;\uace0 \ubc15 \uad50\uc218\ub294 \ub367\ubd99\uc600\ub2e4.<\/p>\n<p>\ub3d9\ub9e5\uacbd\ud654\uac00 \uc2ec\ud574 \uc99d\uc0c1\uc774 \ub098\ud0c0\ub09c \uacbd\uc6b0\ub294 \ubcf5\uc6a9\uc774 \uad8c\uc7a5\ub41c\ub2e4. \uc11c\uc6b8\ub300\ubcd1\uc6d0 \uc21c\ud658\uae30\ub0b4\uacfc \ubc15\uacbd\uc6b0 \uad50\uc218\ub294 &#8220;\uc774\ubbf8 \uc2ec\uadfc\uacbd\uc0c9\uc99d\uc774\ub098 \ub1cc\uacbd\uc0c9, \ub3d9\ub9e5\uacbd\ud654\ub85c \uc778\ud55c \ud608\uad00\ud3d0\uc1c4 \ub4f1\uc774 \uc0dd\uae34 \uacbd\uc6b0\ub294 \uc7ac\ubc1c \ubc29\uc9c0\ub97c \uc704\ud574 \ubc18\ub4dc\uc2dc \ubcf5\uc6a9\ud574\uc57c \ud55c\ub2e4&#8221;\uba70 &#8220;\uba39\ub358 \uc544\uc2a4\ud53c\ub9b0\uc744 \uc911\ub2e8\ud560 \ub54c\ub294 \uc758\uc0ac\uc758 \ubd84\uc11d\uc744 \ub4e4\uc5b4\ubcf4\uace0 \uacb0\uc815\ud558\ub294 \uac8c \uc88b\ub2e4&#8221;\uace0 \ub9d0\ud588\ub2e4.<\/p>\n<\/section>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>(\uc6d0\ubb38: <a href=\"https:\/\/news.v.daum.net\/v\/20190517030901995?f=m\">\uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>https:\/\/www.nature.com\/articles\/d41586-018-06728-z?utm_source=feedburner&#038;utm_medium=feed&#038;utm_campaign=Feed%3A+nature%2Frss%2Fcurrent+%28Nature+-+Issue%29<\/p>\n<p>&nbsp;<\/p>\n<h5 class=\"article-item__title serif\">A daily aspirin might not be what the doctor ordered<\/h5>\n<h6 class=\"article-item__teaser-text serif\">A drug taken regularly by half of US adults might raise the risk of serious bleeding.<\/h6>\n<p>&nbsp;<\/p>\n<div class=\"article-item__body serif\">\n<p>Taking aspirin daily does not significantly prevent first-time cardiovascular disease in healthy elderly people \u2014 and might even be harmful.<\/p>\n<p>Medical advice has long held that low doses of aspirin can reduce the risk of heart attacks and strokes. Starting in 2010, John McNeil of Monash University in Melbourne, Australia, and his colleagues enrolled 19,114 healthy people aged 65 or older in the United States and Australia in a comprehensive trial to investigate aspirin\u2019s benefits. The researchers randomly assigned half of this group to take low-dose aspirin every day and the other half to take a placebo.<\/p>\n<p>Almost five years later, the researchers found that, compared with people in the control arm, people who had taken aspirin were significantly more likely to have had a major haemorrhage, and that more had died of cancer. Aspirin-takers also had a similar rate of new cardiovascular disease as people who had taken a placebo.<\/p>\n<p>The researchers say that the result was unexpected, given that previous studies had found aspirin to be protective against cardiovascular disease in high-risk patients, and they say that further research is needed.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<div class=\"article__sidebar\">\n<p class=\"article-item__original-research strong\"><a class=\"serif\" href=\"https:\/\/doi.org\/10.1056\/NEJMoa1805819\" data-track=\"click\" data-track-label=\"original research\"><i>N. Engl. J. Med.<\/i>\u00a0(2018)<\/a>\u00a0<a class=\"serif\" href=\"https:\/\/doi.org\/10.1056\/NEJMoa1800722\" data-track=\"click\" data-track-label=\"original research\"><i>N. Engl. J. Med.<\/i>\u00a0(2018)<\/a>\u00a0<a class=\"serif\" href=\"https:\/\/doi.org\/10.1056\/NEJMoa1803955\" data-track=\"click\" data-track-label=\"original research\"><i>N. Engl. J. Med.<\/i>\u00a0(2018)<\/a><\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>http:\/\/www.sedaily.com\/NewsView\/1S4SSYAHUT<\/p>\n<p>&nbsp;<\/p>\n<h5>&#8220;\uc544\uc2a4\ud53c\ub9b0, \uc554 \ud658\uc790 \uc0dd\uc874\uc728 \ub192\uc774\uace0 \uc554 \uc804\uc774\uc704\ud5d8 \ub0ae\ucd94\ub294\ub370 \ud6a8\uacfc&#8221;<\/h5>\n<p>&nbsp;<\/p>\n<p><strong class=\"media_end_summary\">\uc601\uad6d \uce74\ub514\ud504\ub300\ud559 \uc5f0\uad6c\ud300, 52\ub9cc\uba85 \uc5f0\uad6c\ub17c\ubb38 \ubd84\uc11d<br \/>\n&#8220;\uc544\uc2a4\ud53c\ub9b0-\uc554 \uc5f0\uad00\uc131 \ubd84\uc11d\ud55c \uacb0\uacfc \uc544\ub0d0\u00b7\u00b7\u00b7\ud6a8\uacfc \ud655\uc99d\uc5d4 \ud55c\uacc4&#8221;<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><span class=\"end_photo_org\"><img decoding=\"async\" src=\"https:\/\/imgnews.pstatic.net\/image\/011\/2018\/09\/27\/0003403285_001_20180927190225841.jpg?type=w647\" \/><\/span><\/p>\n<p><span class=\"end_photo_org\"><em class=\"img_desc\">\uc544\uc2a4\ud53c\ub9b0 \/\uc0ac\uc9c4\uc81c\uacf5=\ubc14\uc774\uc5d8\ucf54\ub9ac\uc544<\/em><\/span><\/p>\n<p>&nbsp;<\/p>\n<p>\uc544\uc2a4\ud53c\ub9b0\uc774 \uc554 \ud658\uc790\uc758 \uc0dd\uc874\uc728\uc744 \ub192\uc774\uace0 \uc554 \uc804\uc774 \uc704\ud5d8\uc744 \ub0ae\ucd94\ub294 \ud6a8\uacfc\uac00 \uc788\ub2e4\ub294 \uc5f0\uad6c\uacb0\uacfc\uac00 \ub098\uc654\ub2e4.<\/p>\n<p>\uc601\uad6d \uce74\ub514\ud504\ub300\ud559 \uc5f0\uad6c\ud300\uc758 \ud53c\ud130 \uc5d8\uc6b0\ub4dc \uc5ed\ud559 \uad50\uc218\uac00 \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\ub294 \uc554 \ud658\uc790 12\ub9cc\uba85\uacfc \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\uc9c0 \uc54a\uc740 \uc554 \ud658\uc790 40\ub9cc\uba85\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc5f0\uad6c\ub17c\ubb38 71\ud3b8\uc758 \uc790\ub8cc\ub97c \ubd84\uc11d\ud55c \uacb0\uacfc \uc774 \uac19\uc740 \uc0ac\uc2e4\uc744 \ubc1c\uacac\ud588\ub2e4\uace0\u00a0<span class=\"word_dic en\">UPI<\/span>\u00a0\ud1b5\uc2e0\uacfc \uba54\ub514\uceec \uc775\uc2a4\ud504\ub808\uc2a4\uac00 26\uc77c(\ud604\uc9c0\uc2dc\uac04) \ubcf4\ub3c4\ud588\ub2e4.<\/p>\n<p>\uc5d8\uc6b0\ub4dc \uad50\uc218\ub294 \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud55c \uc554 \ud658\uc790\uac00 \uc5b4\ub290 \uc2dc\uc810\uc5d0\uc11c\ub3c4 \uc0b4\uc544\uc788\uc744 \uac00\ub2a5\uc131\uc774 \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\uc9c0 \uc54a\ub294 \ud658\uc790\ubcf4\ub2e4 20~30% \ub192\uc558\uace0 \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\ub294 \uc554 \ud658\uc790\uc758 \uacbd\uc6b0 \uc554\uc138\ud3ec\uac00 \ub2e4\ub978 \ubd80\uc704\ub85c \uc804\uc774\ub420 \uac00\ub2a5\uc131\uc774 \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\uc9c0 \uc54a\ub294 \ud658\uc790\uc5d0 \ube44\ud574 \ub208\uc5d0 \ub744\uac8c \ub0ae\uc740 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4\uace0 \ubc1d\ud614\ub2e4.<\/p>\n<p>\uc5d8\uc6b0\ub4dc \uad50\uc218\ub294 \u201c\uc774 \uc5f0\uad6c \ub17c\ubb38 \uc911 \uac70\uc758 \uc808\ubc18\uc740 \ub300\uc7a5\uc554 \ud658\uc790\uac00 \ub300\uc0c1\uc774\uc5c8\uace0 \ub098\uba38\uc9c0 \ub17c\ubb38\uc740 \ub300\ubd80\ubd84 \uc720\ubc29\uc554, \uc804\ub9bd\uc120\uc554 \ud658\uc790\uac00 \ub300\uc0c1\uc774\uc5c8\ub2e4\u201d\uba70 \u201c\uc774 \ubc16\uc5d0 \uc554 \ud658\uc790\uac00 \ub300\uc0c1\uc778 \uc5f0\uad6c\ub17c\ubb38\uc740 \uba87 \ud3b8 \uc5c6\uc9c0\ub9cc \uc804\uccb4\ub97c \uc885\ud569\ud574 \ubcf4\uba74 \ubaa8\ub4e0 \uc554\uc5d0 \uc544\uc2a4\ud53c\ub9b0\uc774 \uc774 \uac19\uc740 \ud6a8\uacfc\uac00 \uc788\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4\u201d\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n<p>\ub2e4\ub9cc \uadf8\ub294 \uc774 \uc5f0\uad6c \ub17c\ubb38\ub4e4\uc740 \uc554 \uce58\ub8cc \ubaa9\uc801\uc774 \uc544\ub2cc \ub2e4\ub978 \uc774\uc720\ub85c \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\ub294 \ud658\uc790\ub4e4\uc774 \ub300\uc0c1\uc774 \ub41c \ub2e8\uc21c \uad00\ucc30\uc5f0\uad6c\uc774\uba70, \uc544\uc2a4\ud53c\ub9b0\uacfc \uc554 \uc0ac\uc774\uc758 \uc5f0\uad00\uc131\uc744 \uc9d1\uc911 \ubd84\uc11d\ud55c \ubb34\uc791\uc704-\ub300\uc870\uad70 \uc124\uc815 \uc784\uc0c1\uc2dc\ud5d8\uc774 \uc544\ub2c8\uc5b4\uc11c \ud6a8\uacfc \ud655\uc99d\uc5d0 \ud55c\uacc4\uac00 \uc788\ub2e4\uace0 \ubc1d\ud614\ub2e4. \ub530\ub77c\uc11c \uc774\ub7ec\ud55c \uc99d\uac70\ub4e4\uc774 100% \uc77c\uad00\ub41c \uac83\uc740 \uc544\ub2c8\uace0 \uc544\uc2a4\ud53c\ub9b0\uc758 \ud6a8\uacfc\uac00 \uc5c6\uc74c\uc744 \ubcf4\uc5ec\uc8fc\ub294 \uc5f0\uad6c \ub17c\ubb38\ub3c4 \uba87 \ud3b8 \uc788\uc5c8\uc5c8\ub2e4\uace0\ub3c4 \ub367\ubd99\uc600\ub2e4. \ub610 \ud604\uc7ac \uc544\uc2a4\ud53c\ub9b0\uacfc \uc554 \uc0ac\uc774\uc758 \uc5f0\uad00\uc131\uc744 \uc99d\uba85\ud558\uae30 \uc704\ud574 \ubb34\uc791\uc704-\ub300\uc870\uad70 \uc124\uc815 \uc784\uc0c1\uc2dc\ud5d8\uc774 \uc9c4\ud589 \uc911\uc774\uba70 \uacb0\uacfc\ub97c \ub3c4\ucd9c\ud558\uae30\uae4c\uc9c0\ub294 \uba87 \ub144 \uac78\ub9b4 \uac83\uc774\ub77c\uace0 \ub9d0\ud588\ub2e4.<\/p>\n<p>\uc5f0\uad6c\ud300\uc740 \uc544\uc2a4\ud53c\ub9b0\uc758 \ub300\ud45c\uc801 \ubd80\uc791\uc6a9\uc778 \ub0b4\ucd9c\ud608 \uc704\ud5d8\uc5d0 \ub300\ud574\uc11c\ub3c4 \uc870\uc0ac\ud588\ub2e4. \uc870\uc0ac\uacb0\uacfc \uc804\uccb4\uc801\uc73c\ub85c \u2018\uc2ec\uac01\ud55c\u2019 \ub0b4\ucd9c\ud608\uc774 \ubc1c\uc0dd\ud55c \ud658\uc790\ub294 \uadf9\uc18c\uc218\uc600\uace0 \ubc1c\uc0dd\ub960\uc740 \uc544\uc2a4\ud53c\ub9b0 \uadf8\ub8f9\uc774\ub098 \uc544\uc2a4\ud53c\ub9b0 \uc774\uc678\uc758 \uc774\uc720\ub85c \uc790\uc5f0\uc801\uc73c\ub85c \uc704 \ucd9c\ud608\uc744 \uacaa\uc740 \ub300\uc870\uad70\uc774\ub098 \ud604\uc800\ud55c \ucc28\uc774\uac00 \uc5c6\uc5c8\ub2e4\uba74\uc11c\ub3c4, \uc544\uc2a4\ud53c\ub9b0 \ubcf5\uc6a9\uc740 \ud655\uc2e4\ud55c \uc784\uc0c1\uc2dc\ud5d8 \uacb0\uacfc\uac00 \ub098\uc62c \ub54c\uae4c\uc9c0 \uac01\uc790\uc758 \ud310\ub2e8\uc5d0 \ub9e1\uae30\ub294 \uac83\uc774 \uc88b\uc744 \uac83\uc774\ub77c\uace0 \uc5d8\uc6b0\ub4dc \ubc15\uc0ac\ub294 \uc5b8\uae09\ud588\ub2e4.<\/p>\n<p>\uc774 \uc5f0\uad6c\uacb0\uacfc\ub294 \uc628\ub77c\uc778 \uacfc\ud559\uc804\ubb38\uc9c0 \u2018\uacf5\uacf5\uacfc\ud559\ub3c4\uc11c\uad00-\uc758\ud559(<span class=\"word_dic en\">PLoS<\/span>\u00a0<span class=\"word_dic en\">One<\/span>\u00a0&#8211;\u00a0<span class=\"word_dic en\">Medicine<\/span>)\u2019 26\uc77c\uc790\uc5d0 \uac8c\uc7ac\ub410\ub2e4.<\/p>\n<p>\uc544\uc2a4\ud53c\ub9b0\uc740 \u2018\uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\ub9ad\uc0b0\u2019\uc774\ub780 \ud654\ud559\uba85\uc744 \uac00\uc9c0\uace0 \uc788\uc73c\uba70 \uac1c\ubc1c\uc0ac\uc778 \ub3c5\uc77c\uc758 \ubc14\uc774\uc5d8 \uc81c\uc57d\ud68c\uc0ac\uc758 \uc0c1\ud488\uba85 \u2018\uc544\uc2a4\ud53c\ub9b0\u2019\uc73c\ub85c\ubd80\ud130 \uc774\ub984\uc744 \ub530\uc654\ub2e4. \uace0\ub4f1\ud559\uad50 \ud654\ud559 \uad50\uacfc\uc11c\uc5d0 \ub098\uc62c \uc815\ub3c4\ub85c \uc81c\ubc95\uc774 \uac04\ub2e8\ud558\uae30\ub3c4 \ud558\uace0 \uad6d\ub0b4 \uc81c\uc57d\ud68c\uc0ac\uc5d0\uc11c\ub3c4 \ub9ce\uc774 \uc0dd\uc0b0\ud574 \uad6c\ud558\uae30 \uc26c\uc6b4 \uc57d\ud488\uc774\ub2e4. \uc5f4\uc744 \ub0ae\ucd94\ub294 \ud6a8\uacfc\ub97c \ube44\ub86f\ud55c \ub2e4\uc591\ud55c \ud6a8\ub2a5\uc744 \uac00\uc838 \uc2ec\ud608\uad00 \uc9c8\ud658 \uc608\ubc29\uc81c\ub098 \uc9c4\ud1b5\uc81c\ub85c \ub9ce\uc774 \uc4f0\uc774\uc9c0\ub9cc, \ubd80\uc791\uc6a9\uc778 \ud56d\uc751\uace0 \uc131\uc9c8\ub85c \uc778\ud574 \uc704\uada4\uc591, \ud1b5\ud48d, \ub0b4\ucd9c\ud608 \ub4f1\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\uc5b4 \uc12d\ucde8\uc5d0 \uc8fc\uc758\ub97c \uc694\uad6c\ud558\ub294 \uc57d\ud488\uc774\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>WIKIPEDIA \ub0b4\uc6a9 &#8211; 2018\ub144 9\uc6d4 20\uc77c \ud604\uc7ac<\/p>\n<p>&nbsp;<\/p>\n<p><b>\uc544\uc2a4\ud53c\ub9b0<\/b>(Aspirin) \ub610\ub294\u00a0<b>\uc544\uc138\ud2f8 \uc0b4\ub9ac\uc2e4\uc0b0<\/b>(<span lang=\"en\">acetylsalicylic acid, ASA<\/span>)\uc740\u00a0<a title=\"\uc0b4\ub9ac\uc2e4\uc0b0\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0\">\uc0b4\ub9ac\uc2e4\uc0b0\uc5fc<\/a>\u00a0\uc758\uc57d\ud488\uc774\ub2e4.\u00a0<a title=\"\uc9c4\ud1b5\uc81c\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%A7%84%ED%86%B5%EC%A0%9C\">\uc9c4\ud1b5\uc81c<\/a>,\u00a0<a class=\"new\" title=\"\ud574\uc5f4\uc81c (\uc5c6\ub294 \ubb38\uc11c)\" href=\"https:\/\/ko.wikipedia.org\/w\/index.php?title=%ED%95%B4%EC%97%B4%EC%A0%9C&amp;action=edit&amp;redlink=1\">\ud574\uc5f4\uc81c<\/a>\ub85c \uc4f0\uace0, \ud608\uc911 \ub18d\ub3c4\ub97c \ub0ae\ucd94\uc5b4\u00a0<a class=\"mw-redirect\" title=\"\uc2ec\ud608\uad00\uc9c8\ud658\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%8B%AC%ED%98%88%EA%B4%80%EC%A7%88%ED%99%98\">\uc2ec\ud608\uad00\uc9c8\ud658<\/a>\uc774\ub098\u00a0<a class=\"mw-disambig\" title=\"\uc2ec\uc7a5\ub9c8\ube44\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%8B%AC%EC%9E%A5%EB%A7%88%EB%B9%84\">\uc2ec\uc7a5\ub9c8\ube44<\/a>\u00a0\uc608\ubc29\uc57d\uc73c\ub85c \uc7a5\uae30\uac04 \uc4f4\ub2e4. \ubc18\uac10\uae30\ub294 300~650\u00a0mg \uc77c \uacbd\uc6b0 3.1 &#8211; 3.2\uc2dc\uac04, 1g\uc77c \uacbd\uc6b0 6\uc2dc\uac04, 2g\uc77c \uacbd\uc6b0 9\uc2dc\uac04\uc774\ub2e4.<\/p>\n<p>\u2018\uc544\uc2a4\ud53c\ub9b0\u2019\uc740\u00a0<a title=\"\ubc14\uc774\uc5d8 (\uae30\uc5c5)\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EB%B0%94%EC%9D%B4%EC%97%98_(%EA%B8%B0%EC%97%85)\">\ubc14\uc774\uc5d8\uc0ac<\/a>\uc758 \uc0c1\ud45c\uba85\uc774\uc9c0\ub9cc, \uba87\uba87 \ub098\ub77c\uc5d0\uc11c\ub294 \uc544\uc2a4\ud53c\ub9b0\uc744 \uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0\uc774\ub77c\ub294 \ubb3c\uc9c8\uba85\uc73c\ub85c \ubd80\ub974\uae30\ub3c4 \ud55c\ub2e4. \uc544\uc2a4\ud53c\ub9b0\uc740\u00a0<a class=\"new\" title=\"\ud504\ub85c\ud2b8\ub86c\ube48 (\uc5c6\ub294 \ubb38\uc11c)\" href=\"https:\/\/ko.wikipedia.org\/w\/index.php?title=%ED%94%84%EB%A1%9C%ED%8A%B8%EB%A1%AC%EB%B9%88&amp;action=edit&amp;redlink=1\">\ud504\ub85c\ud2b8\ub86c\ube48<\/a>\u00a0\uc0dd\uc131 \uc5b5\uc81c\ub97c \ud1b5\ud55c \ud608\uc18c\ud310 \uc81c\uac70 \ubc18\uc751\uc744 \ud558\uae30 \ub54c\ubb38\uc5d0 \ud56d\uc751\uace0 \uc791\uc6a9\uc744 \ud558\uc5ec \ud608\uc804\uc744 \uc608\ubc29 \ud560 \uc218 \uc788\ub2e4. \uc774 \ub54c\ubb38\uc5d0 \uae09\uc131 \uc2ec\uc7a5\ub9c8\ube44\uc5d0 \uc0ac\uc6a9\ud55c\ub2e4. \uadf8\ub7ec\ub098 \ud1b5\uc99d \uc5b5\uc81c\ub97c \uc704\ud55c \ubcf5\uc6a9 \uc2dc \uc774\ub294 \uacfc\ub2e4 \ucd9c\ud608\uacfc \uac19\uc740 \ubd80\uc791\uc6a9\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\ub2e4.<\/p>\n<p><a title=\"\ubc84\ub4dc\ub098\ubb34\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EB%B2%84%EB%93%9C%EB%82%98%EB%AC%B4\">\ubc84\ub4dc\ub098\ubb34<\/a>\u00a0\uaecd\uc9c8\uc5d0 \ud568\uc720\ub41c\u00a0<a title=\"\uc0b4\ub9ac\uc2e4\uc0b0\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0\">\uc0b4\ub9ac\uc2e4\uc0b0<\/a>\uc774\ub77c\ub294 \ubb3c\uc9c8\uc5d0\uc11c \ube44\ub86f\ub41c \uc544\uc2a4\ud53c\ub9b0\uc740 \uae30\uc6d0\uc804(BC) 1\ucc9c500\ub144\ucbe4 \uace0\ub300\u00a0<a title=\"\uc774\uc9d1\ud2b8\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%9D%B4%EC%A7%91%ED%8A%B8\">\uc774\uc9d1\ud2b8<\/a>\uc5d0\uc11c \uc791\uc131\ub41c\u00a0<a title=\"\ud30c\ud53c\ub8e8\uc2a4\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%ED%8C%8C%ED%94%BC%EB%A3%A8%EC%8A%A4\">\ud30c\ud53c\ub8e8\uc2a4<\/a>\uc5d0\uc11c \uc5b8\uae09\ub41c\ub2e4. \uc544\uc2a4\ud53c\ub9b0\ud558\uba74 \ubc14\uc774\uc5d8\uc744 \uc5f0\uc0c1\ud558\uc9c0\ub9cc \ucd5c\ucd08\uc758 \ud0c4\uc0dd\uc5ed\uc0ac\ub294 \uae30\uc6d0\uc804\uc73c\ub85c \uc62c\ub77c\uac00\uace0 \ud604\ub300\uc758\uc57d\uc73c\ub85c \ud2b9\ud5c8\ub97c \ucd5c\ucd08\ub85c \ub4f1\ub85d\ud55c \ub3c5\uc77c\uc758 \ubc14\uc774\uc5d8AG\uc0ac\uac00 \ubca0\ub97c\ub9b0\uc758 \uc81c\uad6d \ud2b9\ud5c8\uad6d\uc5d0 \uc790\uc0ac\uc758 \uc0c1\ud45c\ub97c \ub4f1\ub85d\ud55c \ub0a0\ub85c\ubd80\ud130 \uc57d 110\ub144\uc774 \ub418\uc5c8\ub2e4. \uadf8\ub3d9\uc548 \uc544\uc2a4\ud53c\ub9b0\uc740 \uc138\uacc4\uc5d0\uc11c \uac00\uc7a5 \uc0dd\uba85\uc774 \uae38\uace0 \uac00\uc7a5 \ub180\ub77c\uc6b4 \uc57d\uc784\uc774 \uc785\uc99d\ub418\uc5c8\ub2e4. BC 400\ub144\ucbe4\uc5d0\ub294 &#8216;\uc758\ud559\uc758 \uc544\ubc84\uc9c0&#8217;\ub85c \ubd88\ub9ac\ub294 \uadf8\ub9ac\uc2a4\uc758\u00a0<a title=\"\ud788\ud3ec\ud06c\ub77c\ud14c\uc2a4\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%ED%9E%88%ED%8F%AC%ED%81%AC%EB%9D%BC%ED%85%8C%EC%8A%A4\">\ud788\ud3ec\ud06c\ub77c\ud14c\uc2a4<\/a>\uac00 \uc0ac\uc6a9\ud588\ub2e4\ub294 \uae30\ub85d\uc774 \uc788\ub2e4. \uadf8 \ud6c4 2\ucc9c\uc5ec \ub144\uc774 \uc9c0\ub098 \uc601\uad6d\uc5d0\uc11c\u00a0<a class=\"mw-disambig\" title=\"\uc5d0\ub4dc\uc6cc\ub4dc \uc2a4\ud1a4\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%97%90%EB%93%9C%EC%9B%8C%EB%93%9C_%EC%8A%A4%ED%86%A4\">\uc5d0\ub4dc\uc6cc\ub4dc \uc2a4\ud1a4<\/a>\uc774\ub77c\ub294 \uc131\uc9c1\uc790\uac00 \ubc31\ubc84\ub4dc\ub098\ubb34 \uaecd\uc9c8 \uc999\uc744 \uc5f4\uc774 \uc788\ub294 \uc0ac\ub78c 50\uba85\uc5d0\uac8c \uba39\uc5ec \ud574\uc5f4\uc791\uc6a9\uc744 \ud655\uc778\ud588\ub2e4. \uadf8\ub294 \uc774 \uc0ac\uc2e4\uc744 1763\ub144\u00a0<a class=\"new\" title=\"\ub7f0\ub358 \uc655\ub9bd\ud559\ud68c (\uc5c6\ub294 \ubb38\uc11c)\" href=\"https:\/\/ko.wikipedia.org\/w\/index.php?title=%EB%9F%B0%EB%8D%98_%EC%99%95%EB%A6%BD%ED%95%99%ED%9A%8C&amp;action=edit&amp;redlink=1\">\ub7f0\ub358 \uc655\ub9bd\ud559\ud68c<\/a>\uc5d0\uc11c \ubc1c\ud45c\ud588\ub2e4. \uc57d 60\ub144 \ud6c4\uc5d0 \uc774\ud0c8\ub9ac\uc544 \ud654\ud559\uc790 \ud53c\ub9ac\uc544\ub294 \ubc84\ub4dc\ub098\ubb34 \uaecd\uc9c8\uc5d0\uc11c \uc57d\ud6a8\uc758 \uc8fc\uc131\ubd84\uc778\u00a0<a title=\"\uc0b4\ub9ac\uc2e0\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%82%B4%EB%A6%AC%EC%8B%A0\">\uc0b4\ub9ac\uc2e0<\/a>\uc744 \ubd84\ub9ac\ud588\ub2e4. \uadf8 \ub4a4 \uba87 \ub2e8\uacc4 \ud654\ud559 \ubc18\uc751\uc744 \uac70\uccd0 \uc544\uc2a4\ud53c\ub9b0\uc758 \ubaa8\uccb4\uc778\u00a0<a title=\"\uc0b4\ub9ac\uc2e4\uc0b0\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0\">\uc2e4\ub9ac<\/a>\uc744 \uc5bb\uc5c8\ub2e4.<sup id=\"cite_ref-1\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%8A%A4%ED%94%BC%EB%A6%B0#cite_note-1\">[1]<\/a><\/sup>\u00a0\uc0b4\ub9ac\uc2e4\uc0b0\uc740 \uc758\ud559\uc801\uc778 \ud6a8\uacfc\uac00 \uc788\uc5c8\uc9c0\ub9cc\u00a0<a class=\"new\" title=\"\uc704\ubcbd (\uc5c6\ub294 \ubb38\uc11c)\" href=\"https:\/\/ko.wikipedia.org\/w\/index.php?title=%EC%9C%84%EB%B2%BD&amp;action=edit&amp;redlink=1\">\uc704\ubcbd<\/a>\uc744 \uc790\uadf9\ud558\uba70\u00a0<a title=\"\uc124\uc0ac\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%84%A4%EC%82%AC\">\uc124\uc0ac<\/a>\ub97c \uc77c\uc73c\ud0a4\uace0, \ub9ce\uc774 \uba39\uc744 \uacbd\uc6b0 \uc8fd\ub294 \uacbd\uc6b0\ub3c4 \uc788\uc5c8\ub2e4. 1897\ub144 \ub3c5\uc77c\u00a0<a title=\"\ubc14\uc774\uc5d8 (\uae30\uc5c5)\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EB%B0%94%EC%9D%B4%EC%97%98_(%EA%B8%B0%EC%97%85)\">\ubc14\uc774\uc5d8<\/a>\u00a0\uc0ac\uc758 \uc5f0\uad6c\uc6d0\u00a0<a title=\"\ud3a0\ub9ad\uc2a4 \ud638\ud504\ub9cc\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%ED%8E%A0%EB%A6%AD%EC%8A%A4_%ED%98%B8%ED%94%84%EB%A7%8C\">\ud3a0\ub9ad\uc2a4 \ud638\ud504\ub9cc<\/a><sup id=\"cite_ref-2\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%8A%A4%ED%94%BC%EB%A6%B0#cite_note-2\">[2]<\/a><\/sup>\uc740\u00a0<a title=\"\uc0b4\ub9ac\uc2e4\uc0b0\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0\">\uc0b4\ub9ac\uc2e4\uc0b0<\/a>\uc758\u00a0<a class=\"mw-redirect\" title=\"\ud788\ub4dc\ub85d\uc2dc\uae30\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%ED%9E%88%EB%93%9C%EB%A1%9D%EC%8B%9C%EA%B8%B0\">\ud788\ub4dc\ub85d\uc2dc\uae30<\/a>\ub97c\u00a0<a class=\"new\" title=\"\uc544\uc138\ud2f8\uae30 (\uc5c6\ub294 \ubb38\uc11c)\" href=\"https:\/\/ko.wikipedia.org\/w\/index.php?title=%EC%95%84%EC%84%B8%ED%8B%B8%EA%B8%B0&amp;action=edit&amp;redlink=1\">\uc544\uc138\ud2f8\uae30<\/a>\uc640\u00a0<a class=\"mw-redirect\" title=\"\uc5d0\uc2a4\ud14c\ub974\ud654\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%97%90%EC%8A%A4%ED%85%8C%EB%A5%B4%ED%99%94\">\uc5d0\uc2a4\ud14c\ub974\ud654<\/a>\u00a0\ubc18\uc751\uc744 \uc2dc\ucf1c \uc544\uc2a4\ud53c\ub9b0\uc744 \ub9cc\ub4e4\uc5c8\ub294\ub370\u00a0<a title=\"\uc0b4\ub9ac\uc2e4\uc0b0\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0\">\uc0b4\ub9ac\uc2e4\uc0b0<\/a>\uc758 \ubd80\uc791\uc6a9\uc774 \ud06c\uac8c \uc904\uc5b4\ub4e4\uc5c8\ub2e4. \uc774\ub294 \ucd5c\ucd08\uc758\u00a0<a class=\"new\" title=\"\ud569\uc131 \uc758\uc57d\ud488 (\uc5c6\ub294 \ubb38\uc11c)\" href=\"https:\/\/ko.wikipedia.org\/w\/index.php?title=%ED%95%A9%EC%84%B1_%EC%9D%98%EC%95%BD%ED%92%88&amp;action=edit&amp;redlink=1\">\ud569\uc131 \uc758\uc57d\ud488<\/a>\uc774\ub2e4. \ubc14\uc774\uc5d8 \uc0ac\ub294 1899\ub144 3\uc6d4 6\uc77c &#8220;\ud574\uc5f4 \uc9c4\ud1b5\uc81c&#8221; \uc544\uc2a4\ud53c\ub9b0\uc758 \ud2b9\ud5c8\ub97c \ub4f1\ub85d\ud588\ub2e4. 1914\ub144, \ucd08\uae30\uc758 \uac00\ub8e8 \uc57d\uc744 \uc54c\uc57d \ud615\ud0dc\ub85c \uad50\uccb4, \ubcf5\uc6a9\uc744 \uac04\ud3b8\ud558\uac8c \ud558\uace0 \ubcf5\uc6a9\ub7c9\uc744 \ud45c\uc900\ud654\ud568\uc73c\ub85c\uc368 \ub354\uc6b1 \ub300\uc911\ud654\ud588\ub2e4.<sup id=\"cite_ref-3\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%8A%A4%ED%94%BC%EB%A6%B0#cite_note-3\">[3]<\/a><\/sup><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><b>\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c<\/b>(acetaminophen) \ub610\ub294\u00a0<b>\ud30c\ub77c\uc138\ud0c0\ubab0<\/b>(paracetamol)\uc740\u00a0<a class=\"mw-selflink selflink\">\ud0c0\uc774\ub808\ub180<\/a>,\u00a0<a title=\"\ud39c\uc798\ud050\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%ED%8E%9C%EC%9E%98%ED%81%90\">\ud39c\uc798\ud050<\/a>,\u00a0<a class=\"new\" title=\"\uac8c\ubcf4\ub9b0 (\uc5c6\ub294 \ubb38\uc11c)\" href=\"https:\/\/ko.wikipedia.org\/w\/index.php?title=%EA%B2%8C%EB%B3%B4%EB%A6%B0&amp;action=edit&amp;redlink=1\">\uac8c\ubcf4\ub9b0<\/a>,\u00a0<a class=\"new\" title=\"\ud310\ud53c\ub9b0 (\uc5c6\ub294 \ubb38\uc11c)\" href=\"https:\/\/ko.wikipedia.org\/w\/index.php?title=%ED%8C%90%ED%94%BC%EB%A6%B0&amp;action=edit&amp;redlink=1\">\ud310\ud53c\ub9b0<\/a>,\u00a0<a class=\"new\" title=\"\uc554\uc528\ub871 (\uc5c6\ub294 \ubb38\uc11c)\" href=\"https:\/\/ko.wikipedia.org\/w\/index.php?title=%EC%95%94%EC%94%A8%EB%A1%B1&amp;action=edit&amp;redlink=1\">\uc554\uc528\ub871<\/a>\uc758 \uc8fc\uc131\ubd84\uc73c\ub85c \ud574\uc5f4 \uc9c4\ud1b5 \uc791\uc6a9\uc744 \ud55c\ub2e4. \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uacfc \ud30c\ub77c\uc138\ud0c0\ubab0 \ubaa8\ub450 \uadf8 \ud654\ud559\uba85\uc778 para-acetylaminophenol\uc758 \uc904\uc784\ub9d0\uc774\ub2e4. (para-<b>acet<\/b>yl<b>aminophen<\/b>ol,\u00a0<b>par<\/b>a-<b>acet<\/b>yl<b>am<\/b>inophen<b>ol<\/b>)<\/p>\n<p><span id=\".ED.9A.A8.EB.8A.A5\"><\/span><span id=\"\ud6a8\ub2a5\" class=\"mw-headline\">\ud6a8\ub2a5<\/span><\/p>\n<p>\ub450\ud1b5\uacfc \ud574\uc5f4 \ubc0f \uae30\ud0c0 \ud1b5\uc99d \uc644\ud654\uc5d0 \ud6a8\uacfc\uc801\uc774\uba70, \uc704\uc7a5\uc7a5\uc560\uc5d0 \ub300\ud55c \ubd80\ub2f4\uc774 \uc801\ub2e4. \ub2e4\ub9cc, \uc74c\uc2dd\ubb3c\uacfc \ud568\uaed8 \uc12d\ucde8\ud558\uba74 \uc57d\ud6a8\uac00 \ub5a8\uc5b4\uc9c8 \uc218 \uc788\uc73c\ubbc0\ub85c \uac00\uae09\uc801 \uacf5\ubcf5\uc5d0 \uc12d\ucde8\ud558\ub294 \uac83\uc774 \uc88b\ub2e4.\u00a0<sup id=\"cite_ref-1\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-1\">[1]<\/a><\/sup>\u00a0\uc0dd\ub9ac\ud1b5, \uce58\ud1b5,\u00a0<a title=\"\uad00\uc808\ud1b5\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EA%B4%80%EC%A0%88%ED%86%B5\">\uad00\uc808\ud1b5<\/a>\uc758 \ud1b5\uc99d \uc644\ud654\uc5d0\ub3c4 \ud6a8\uacfc\uc801\uc774\uba70, \ub2e4\ub978 \uc57d\ud488\uacfc \ubc18\uc751\ud558\uc9c0 \uc54a\uc73c\ub098 \uac04\ub3c5\uc131\uc758 \uc704\ud5d8\uc774 \uc788\uc5b4 \uc74c\uc8fc \ud6c4\uc5d0\ub294 \ubcf5\uc6a9\uc744 \uad8c\uc7a5\ud558\uc9c0 \uc54a\ub294\ub2e4<sup id=\"cite_ref-2\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-2\">[2]<\/a><\/sup><\/p>\n<p><span id=\".EB.B0.9C.EA.B2.AC\"><\/span><span id=\"\ubc1c\uacac\" class=\"mw-headline\">\ubc1c\uacac<\/span><\/p>\n<p>1940\ub144\ub300\uae4c\uc9c0\ub294 \ube44<a title=\"\uc544\uc2a4\ud53c\ub9b0\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%8A%A4%ED%94%BC%EB%A6%B0\">\uc544\uc2a4\ud53c\ub9b0<\/a>\uacc4\uc758\u00a0<a title=\"\uc9c4\ud1b5\uc81c\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%A7%84%ED%86%B5%EC%A0%9C\">\uc9c4\ud1b5\uc81c<\/a>\ub85c \uc544\uc138\ud2b8\uc544\ub2d0\ub9ac\ub4dc(acetanilide)\ub97c \uc0ac\uc6a9\ud558\uc600\uc73c\ub098\u00a0<a title=\"\ud328\ud608\uc99d\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%ED%8C%A8%ED%98%88%EC%A6%9D\">\ud328\ud608\uc99d<\/a>\u00a0\uc9c8\ud658 \ubc0f\u00a0<a class=\"new\" title=\"\uba54\ud2b8\ud5e4\ubaa8\uae00\ub85c\ube48\ud608\uc99d (\uc5c6\ub294 \ubb38\uc11c)\" href=\"https:\/\/ko.wikipedia.org\/w\/index.php?title=%EB%A9%94%ED%8A%B8%ED%97%A4%EB%AA%A8%EA%B8%80%EB%A1%9C%EB%B9%88%ED%98%88%EC%A6%9D&amp;action=edit&amp;redlink=1\">\uba54\ud2b8\ud5e4\ubaa8\uae00\ub85c\ube48\ud608\uc99d<\/a>\u00a0\ub4f1\uc758 \ubd80\uc791\uc6a9\uc774 \uc788\uc5c8\ub2e4. \ubbf8\uad6d\uc758\u00a0<a title=\"\uc0dd\ud654\ud559\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%83%9D%ED%99%94%ED%95%99\">\uc0dd\ud654\ud559<\/a>\uc790\uc778 \uc904\ub9ac\uc5b4\uc2a4 \uc561\uc140\ub85c\ub4dc(Julius Axelrod)\uc640 \ubc84\ub098\ub4dc \ube0c\ub85c\ub514(Bernard B. Brodie)\ub294 \uc544\uc138\ud2b8\uc544\ub2d0\ub9ac\ub4dc\uc758 \uc778\uccb4\ub0b4 \ub300\uc0ac\uc0b0\ubb3c\uc778 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774 \uc544\uc138\ud2b8\uc544\ub2d0\ub9ac\ub4dc\uc640 \ub3d9\ub4f1\ud55c \uc9c4\ud1b5\ud6a8\uacfc\ub97c \ub098\ud0c0\ub0b8\ub2e4\ub294 \uac83\uc744 \ubc1c\uacac\ud588\ub2e4.\u00a0<sup id=\"cite_ref-3\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-3\">[3]<\/a><\/sup><sup id=\"cite_ref-4\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-4\">[4]<\/a><\/sup><sup id=\"cite_ref-5\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-5\">[5]<\/a><\/sup><\/p>\n<p><span id=\".EC.A0.9C.EB.B2.95\"><\/span><span id=\"\uc81c\ubc95\" class=\"mw-headline\">\uc81c\ubc95<\/span><\/p>\n<p>\uc2e4\ud5d8\uc2e4\uc5d0\uc11c \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc744 \ub9cc\ub4e4\uae30 \uc704\ud574\uc11c\ub294 \ud398\ub180\uc5d0 \ubb3d\uc740\u00a0<a title=\"\ud669\uc0b0\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%ED%99%A9%EC%82%B0\">\ud669\uc0b0<\/a>\uacfc \ud568\uaed8 \uc9c8\uc0b0\ub098\ud2b8\ub968\uc744 \ucca8\uac00\ud558\uba74\u00a0<a title=\"\ud398\ub180\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%ED%8E%98%EB%86%80\">\ud398\ub180<\/a>\uc758\u00a0<a title=\"\ubca4\uc820\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EB%B2%A4%EC%A0%A0\">\ubca4\uc820<\/a>\u00a0\uace0\ub9ac\uac00 \ub2c8\ud2b8\ub85c\ud654 \ubc18\uc751\uc744 \ud558\uc5ec p-\ub2c8\ud2b8\ub85c\ud398\ub180(p-nitrophenol)\uacfc \ubd80\uc0b0\ubb3c\ub85c o-\ub2c8\ud2b8\ub85c\ud398\ub180(o-nitrophenol)\uc774 \uc0dd\uc131\ub41c\ub2e4. p-\ub2c8\ud2b8\ub85c\ud398\ub180\uc744 \uc815\uc81c\ud558\uc5ec \uc218\uc18c\ud654\ubd95\uc18c\ub098\ud2b8\ub968(sodium borohydride)\uc744 \ucca8\uac00\ud558\uba74 4-\uc544\ubbf8\ub178\ud398\ub180(4-aminophenol)\ub85c \ud658\uc6d0\ub41c\ub2e4. \uc5ec\uae30\uc5d0 \ubb34\uc218<a title=\"\uc544\uc138\ud2b8\uc0b0\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%82%B0\">\uc544\uc138\ud2b8\uc0b0<\/a>(acetic anhydride)\uc744 \ub123\uc73c\uba74\u00a0<a title=\"\uc544\ubbf8\ub178\uae30\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EB%AF%B8%EB%85%B8%EA%B8%B0\">\uc544\ubbf8\ub178\uae30<\/a>\uc640 \ubc18\uc751\ud558\uc5ec \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774 \ub41c\ub2e4.<sup id=\"cite_ref-6\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-6\">[6]<\/a><\/sup><\/p>\n<p><span id=\".EC.9E.91.EC.9A.A9_.EB.A9.94.EC.BB.A4.EB.8B.88.EC.A6.98\"><\/span><span id=\"\uc791\uc6a9_\uba54\ucee4\ub2c8\uc998\" class=\"mw-headline\">\uc791\uc6a9 \uba54\ucee4\ub2c8\uc998<\/span><\/p>\n<p>\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc758 \uc791\uc6a9 \uba54\ucee4\ub2c8\uc998\uc740 \uc544\uc9c1 \uba85\ud655\ud558\uac8c \uaddc\uba85\ub418\uc9c0 \uc54a\uc558\ub2e4. \uc544\uc2a4\ud53c\ub9b0\uac19\uc740 \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\ud56d\uc5fc\uc99d\uc81c\uc640\ub294 \ub2e4\ub974\uac8c, \uc544\uc138\ud2b8 \uc544\ubbf8\ub178\ud39c\uc740 \uc911\ucd94 \uc2e0\uacbd\uacc4 \ubc16\uc758 COX\uc758 \uc5b5\uc81c\uc5d0 \uad00\ud55c \uae30\ub2a5\uc740 \ub098\ud0c0\ub0b4\uc9c0 \uc54a\uc73c\uba70, \uc774\ub294 \uc65c \uc544\uc138\ud2b8 \uc544\ubbf8\ub178\ud39c\uc774 \ud56d\uc5fc\uc99d\uc5d0 \uad00\ud55c \ud6a8\uacfc\uac00 \ubbf8\ubbf8\ud55c\uc9c0\ub97c \uc54c\ub824\uc900\ub2e4.<sup id=\"cite_ref-7\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-7\">[7]<\/a><\/sup>\u00a0\ucd5c\uadfc \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \uc2dc\ud074\ub85c\uc625\uc2dc\uac8c\ub098\uc544\uc81c(cyclooxygenase, COX)\ub97c \uc5b5\uc81c\ud558\ub294 \uc0c8\ub85c\uc6b4 \uba54\ucee4\ub2c8\uc998\uc774 \uc81c\uc548\ub418\uc5c8\uace0, \ud2b9\ud788 COX-2\uc5d0 \uc120\ud0dd\uc801\uc73c\ub85c \uc791\uc6a9\ud558\ub294 \uac83\uc73c\ub85c \ucd94\uc815\ub41c\ub2e4. COX-2\uc5d0 \ub300\ud55c \uc120\ud0dd\uc131 \ub355\ubd84\uc5d0\u00a0<a title=\"\uc544\uc2a4\ud53c\ub9b0\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%8A%A4%ED%94%BC%EB%A6%B0\">\uc544\uc2a4\ud53c\ub9b0<\/a>\uacfc\ub294 \ub2ec\ub9ac \ud608\uc561 \uc751\uace0\uc5d0 \uad00\uc5ec\ud558\ub294 \ud2b8\ub86c\ubcf5\uc0b0\uc758 \uc0dd\uc131\uc744 \uc5b5\uc81c\ud558\uc9c0 \uc54a\ub294\ub2e4.<sup id=\"cite_ref-COX-2_8-0\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-COX-2-8\">[8]<\/a><\/sup>\u00a0\uc774\ub7ec\ud55c \ud65c\uc131\uc740 \ud65c\uc131\ubd80\uc704\ub97c \uc9c1\uc811\uc801\uc73c\ub85c \ucc28\ub2e8\ud568\uc73c\ub85c\uc368 \ub098\ud0c0\ub098\ub294 \uac83\uc774 \uc544\ub2c8\ub77c, \uae30\ub2a5\ud558\uae30 \uc704\ud574\uc120 \uc0b0\ud654\ub418\uc5b4\uc57c\ud558\ub294 COX \uc790\uccb4\ub97c \uc904\uc784\uc73c\ub85c\uc368 \ub098\ud0c0\ub09c\ub2e4.<\/p>\n<p>\ub610\ud55c \uc544\uc138\ud2b8 \uc544\ubbf8\ub178\ud39c\uc740 \ub300\uc0ac\uc0b0\ubb3c AM404\ub97c \ud1b5\ud574 \ub1cc\uc5d0\uc11c \ub0b4\uc778\uc131 \uce78\ub098\ube44\ub178\uc774\ub4dc \uc2dc\uc2a4\ud15c\uc744 \uc870\uc808\ud560 \uc218 \uc788\ub294 \uac83\uc73c\ub85c \ubcf4\uc778\ub2e4. AM404\ub294 \ud1b5\uc99d\uc744 \ub354 \ud6a8\uacfc\uc801\uc73c\ub85c \uac10\uc18c\uc2dc\ud0a4\uae30 \uc704\ud574 \ub274\ub7f0\ub4e4\ub85c\ubd80\ud130\uc758 \ub0b4\uc778\uc131 \uce78\ub098\ube44\ub178\uc774\ub4dc \/ \ubc14\ub2d0\ub85c\uc774\ub4dc \uc544\ub09c\ub2e4\ubbf8\ub4dc\uc758 \uc7ac\ud761\uc218\ub97c \uc5b5\uc81c\ud558\ub294 \uac83\uc73c\ub85c \uc0dd\uac01\ub41c\ub2e4. AM404\ub294 \ub610\ud55c \ub1cc\uc758 \ud1b5\uc99d \uc2e0\ud638\ub97c \uc5b5\uc81c\uc2dc\ud0a4\ub294 TPRv1(\uc61b\ub0a0\uc774\ub984: \ubc14\ub2d0\ub85c\uc774\ub4dc \uc218\uc6a9\uccb4)\ub97c \uc9c1\uc811 \ud65c\uc131\ud654\uc2dc\ud0ac \uc218 \uc788\ub2e4.<sup id=\"cite_ref-9\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-9\">[9]<\/a><\/sup><\/p>\n<p><span id=\".EB.B6.80.EC.9E.91.EC.9A.A9\"><\/span><span id=\"\ubd80\uc791\uc6a9\" class=\"mw-headline\">\ubd80\uc791\uc6a9<\/span><\/p>\n<p><span id=\".EB.A9.94.EC.BB.A4.EB.8B.88.EC.A6.98\"><\/span><span id=\"\uba54\ucee4\ub2c8\uc998\" class=\"mw-headline\">\uba54\ucee4\ub2c8\uc998<\/span><\/p>\n<p>\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc740 \ub0a8\uc6a9\ud560 \uc2dc\uc5d0 \ubd80\uc791\uc6a9\uc744 \ucd08\ub798\ud55c\ub2e4. \uacfc\ub3c4\ud55c \uc591\uc758 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774 \uccb4\ub0b4\uc5d0 \ud22c\uc5ec\ub418\uba74, \uc2dc\ud1a0\ud06c\ub86c P450(Cytochrome P450)\uc774\ub77c\ub294 \uccb4\ub0b4 \ud6a8\uc18c\uac00 N-\uc544\uc138\ud2f8-p-\ubca4\uc870\ud034\ub17c\uc774\ubbfc(N-acetyl-p-benzoquinone imine)\uc73c\ub85c \ubcc0\ud658\ud55c\ub2e4. \uc774 \ubb3c\uc9c8\uc740 \uccb4\ub0b4 \uae00\ub8e8\ud0c0\ud2f0\uc628\uacfc \uacb0\ud569\ud558\uc5ec \uac04\uc758 \uae30\ub2a5\uc744 \uc800\ud558\uc2dc\ud0a8\ub2e4.<sup id=\"cite_ref-biochem_10-0\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-biochem-10\">[10]<\/a><\/sup><\/p>\n<p><span id=\".EC.A6.9D.EC.83.81\"><\/span><span id=\"\uc99d\uc0c1\" class=\"mw-headline\">\uc99d\uc0c1<\/span><\/p>\n<p>\uacfc\ub7c9 \ubcf5\uc6a9\uc73c\ub85c \uc778\ud574\u00a0<a title=\"\uac04\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EA%B0%84\">\uac04<\/a>\u00a0\uae30\ub2a5\uc774 \uc800\ud558\ub418\uc5b4\u00a0<a class=\"mw-redirect\" title=\"\ud604\uae30\uc99d\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%ED%98%84%EA%B8%B0%EC%A6%9D\">\ud604\uae30\uc99d<\/a>\uacfc\u00a0<a title=\"\uad6c\ud1a0\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EA%B5%AC%ED%86%A0\">\uad6c\ud1a0<\/a>, \uc54c\ub808\ub974\uae30 \ub4f1\uc744 \uc720\ubc1c\ud558\uba70 24~48\uc2dc\uac04 \uc774\ub0b4\uc5d0\u00a0<a title=\"\uac04\ubd80\uc804\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EA%B0%84%EB%B6%80%EC%A0%84\">\uac04\ubd80\uc804<\/a>\uc774 \ub098\ud0c0\ub0a0 \uc218\ub3c4 \uc788\ub2e4.<sup id=\"cite_ref-biochem_10-1\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-biochem-10\">[10]<\/a><\/sup>\u00a0<a title=\"\uac04\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EA%B0%84\">\uac04<\/a>\uc5d0 \ubb34\ub9ac\ub97c \uc8fc\uae30 \ub54c\ubb38\uc5d0\u00a0<a title=\"\uc220\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%88%A0\">\uc220<\/a>\uc744 \ub9c8\uc168\uc744 \ub54c\uc5d0\ub294 \ubcf5\uc6a9\uc744 \uc0bc\uac00\uc57c \ud55c\ub2e4.<sup id=\"cite_ref-11\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-11\">[11]<\/a><\/sup>\u00a0\ub610\ud55c\u00a0<a class=\"mw-redirect\" title=\"\uc720\uc544\uae30\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%9C%A0%EC%95%84%EA%B8%B0\">\uc720\uc544\uae30<\/a>\uc758 \uc5b4\ub9b0 \uc544\uc774\uc5d0\uac8c \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc744 \ud22c\uc5ec\ud558\uba74\u00a0<a class=\"mw-redirect\" title=\"\uc544\ub3d9\uae30\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EB%8F%99%EA%B8%B0\">\uc544\ub3d9\uae30<\/a>\uc5d0\u00a0<a title=\"\ucc9c\uc2dd\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%B2%9C%EC%8B%9D\">\ucc9c\uc2dd<\/a>\u00a0\ubc1c\ubcd1\ub960\uc774 \ub192\uc544\uc9c4\ub2e4\ub294 \uc5f0\uad6c \uacb0\uacfc\uac00 \ubcf4\ub3c4\ub418\uc5c8\ub2e4.<sup id=\"cite_ref-12\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-12\">[12]<\/a><\/sup>\u00a0<a title=\"\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%9E%84%EC%8B%A0\">\uc784\uc2e0<\/a>\u00a0\uae30\uac04 \uc911, \ud2b9\ud788 4~6\uac1c\uc6d4 \uc911\uc5d0 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c \ubcf5\uc6a9\uc774 \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ud558\uac8c \ub0a8\uc790 \ud0dc\uc544\uc758 \uc131\uc801 \ubc1c\ub2ec\uc744 \uc800\ud558\uc2dc\ud0a4\ub294 \uac83\uc774 \uad00\ucc30\ub418\uc5c8\ub2e4.<sup id=\"cite_ref-13\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-13\">[13]<\/a><\/sup>\ub9cc\uc131\uc801\uc73c\ub85c \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc744 \ubcf5\uc6a9\ud558\ub294 \uc0ac\ub78c\uc740\u00a0<a title=\"\ud608\uc561\uc554\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%ED%98%88%EC%95%A1%EC%95%94\">\ud608\uc561\uc554<\/a>\uc774 \ubc1c\ubcd1\ud560 \ud655\ub960\uc774 \ub192\uc544\uc9c4\ub2e4.<sup id=\"cite_ref-14\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-14\">[14]<\/a><\/sup>\uc544\uc8fc \ub4dc\ubb3c\uac8c \ud53c\ubd80 \ubc1c\uc9c4\uc744 \uc77c\uc73c\ud0a4\uae30\ub3c4 \ud55c\ub2e4.<sup id=\"cite_ref-15\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#cite_note-15\">[15]<\/a><\/sup><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><b>\uc774\ubd80\ud504\ub85c\ud39c<\/b>(Ibuprofen, \uc774\uc804 \uc774\ub984: \uc774\uc18c \ubd80\ud2f8 \ud504\ub85c\ud310 \ud398\ub180\uc0b0)\uc740\u00a0<a title=\"\ube44\uc2a4\ud14c\ub85c\uc774\ub4dc \ud56d\uc5fc\uc99d\uc81c\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EB%B9%84%EC%8A%A4%ED%85%8C%EB%A1%9C%EC%9D%B4%EB%93%9C_%ED%95%AD%EC%97%BC%EC%A6%9D%EC%A0%9C\">\ube44\uc2a4\ud14c\ub85c\uc774\ub4dc \ud56d\uc5fc\uc99d\uc81c<\/a>\ub85c, \uc6d0\ub798 \uc0c1\ud45c\uba85\uc740 \ubd80\ub8e8\ud39c(Brufen)\uc774\ub2e4. \ub098\ub77c\ub9c8\ub2e4 \ub2e4\ub978 \uc0c1\ud45c\uba85\uc774 \uc788\ub2e4.\u00a0<a class=\"mw-redirect\" title=\"\uc9c4\ud1b5\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%A7%84%ED%86%B5\">\uc9c4\ud1b5<\/a>,\u00a0<a title=\"\uad00\uc808\uc5fc\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EA%B4%80%EC%A0%88%EC%97%BC\">\uad00\uc808\uc5fc<\/a>\u00a0\uc81c\uac70,\u00a0<a class=\"new\" title=\"\ud574\uc5f4 (\uc5c6\ub294 \ubb38\uc11c)\" href=\"https:\/\/ko.wikipedia.org\/w\/index.php?title=%ED%95%B4%EC%97%B4&amp;action=edit&amp;redlink=1\">\ud574\uc5f4<\/a>\uc5d0, \ud2b9\ud788 \uc774\ub4e4\u00a0<a title=\"\uc99d\uc0c1\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%A6%9D%EC%83%81\">\uc99d\uc0c1<\/a>\uc774\u00a0<a title=\"\uc5fc\uc99d\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%97%BC%EC%A6%9D\">\uc5fc\uc99d<\/a>\uc744 \ub3d9\ubc18\ud558\ub294 \uacbd\uc6b0\uc5d0 \uc4f4\ub2e4.\u00a0<a title=\"\uc544\uc2a4\ud53c\ub9b0\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%8A%A4%ED%94%BC%EB%A6%B0\">\uc544\uc2a4\ud53c\ub9b0<\/a>\uc5d0 \ube44\ud574\uc11c\ub294 \uc57d\ud558\uba74\uc11c\ub3c4 \ubc18\uac10\uae30\uac00 \uc9e7\uae30\ub294 \ud558\uc9c0\ub9cc,\u00a0<a class=\"mw-redirect\" title=\"\uc6a9\ud608\uc791\uc6a9\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%9A%A9%ED%98%88%EC%9E%91%EC%9A%A9\">\uc6a9\ud608\uc791\uc6a9<\/a>\uc774 \uc788\ub2e4.\u00a0<a title=\"\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C\">\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c<\/a>\uacfc\ub294 \ub2ec\ub9ac,\u00a0<a title=\"\uc704 (\ud574\ubd80\ud559)\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%9C%84_(%ED%95%B4%EB%B6%80%ED%95%99)\">\uc704\uc7a5<\/a>\uc5d0 \uc601\ud5a5\uc744 \uc904 \uc218 \uc788\uc73c\ubbc0\ub85c \uacf5\ubcf5\uc744 \ud53c\ud558\uc5ec \ubcf5\uc6a9\ud574\uc57c \ud558\uba70, \ud2b9\ud788\u00a0<a title=\"\uc220\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%88%A0\">\uc220<\/a>\uc744 \ub9c8\uc2e0 \uc0c1\ud0dc\uc5d0\uc11c \ubcf5\uc6a9 \uc2dc \uc704\uc7a5\u00a0<a title=\"\ucd9c\ud608\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%B6%9C%ED%98%88\">\ucd9c\ud608<\/a>\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\uc73c\ubbc0\ub85c \ud53c\ud574\uc57c \ud55c\ub2e4.<\/p>\n<p>\uc774\ubd80\ud504\ub85c\ud39c\uc740 1960\ub144\ub300 \ub3d9\uc548\u00a0<a class=\"mw-redirect\" title=\"\ubd80\uce20 \uadf8\ub8f9\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EB%B6%80%EC%B8%A0_%EA%B7%B8%EB%A3%B9\">\ubd80\uce20 \uadf8\ub8f9<\/a>\uc758\u00a0<a title=\"\uc5f0\uad6c\" href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%97%B0%EA%B5%AC\">\uc5f0\uad6c<\/a>\u00a0\ubd80\ubb38\uc5d0 \uc758\ud574\u00a0<a class=\"new\" title=\"\ud504\ub85c\ud53c\uc628\uc0b0 (\uc5c6\ub294 \ubb38\uc11c)\" href=\"https:\/\/ko.wikipedia.org\/w\/index.php?title=%ED%94%84%EB%A1%9C%ED%94%BC%EC%98%A8%EC%82%B0&amp;action=edit&amp;redlink=1\">\ud504\ub85c\ud53c\uc628\uc0b0<\/a>\uc5d0\uc11c \ucd94\ucd9c\ub41c \uac83\uc774\ub2e4.<sup id=\"cite_ref-pmid1569234_1-0\" class=\"reference\"><a href=\"https:\/\/ko.wikipedia.org\/wiki\/%EC%9D%B4%EB%B6%80%ED%94%84%EB%A1%9C%ED%8E%9C#cite_note-pmid1569234-1\">[1]<\/a><\/sup><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>\ub098\ubb34\uc704\ud0a4 \ub0b4\uc6a9 &#8211; 2018\ub144 9\uc6d4 20\uc77c \ud604\uc7ac<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h5>\uc544\uc2a4\ud53c\ub9b0<\/h5>\n<p>&nbsp;<\/p>\n<div class=\"wiki-heading-content\">\n<p><a class=\"wiki-link-internal\" title=\"\ubd84\uc790\uc2dd\" href=\"https:\/\/namu.wiki\/w\/%EB%B6%84%EC%9E%90%EC%8B%9D\">\ubd84\uc790\uc2dd<\/a>\uc740 C<sub>9<\/sub>H<sub>8<\/sub>O<sub>4<\/sub>\uc774\uba70\u00a0<a class=\"wiki-link-internal\" title=\"NSAID\" href=\"https:\/\/namu.wiki\/w\/NSAID\">NSAID<\/a>s, \uc989 \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\u00a0<a class=\"wiki-link-internal\" title=\"\uc9c4\ud1b5\uc81c\" href=\"https:\/\/namu.wiki\/w\/%EC%A7%84%ED%86%B5%EC%A0%9C\">\uc9c4\ud1b5\uc81c<\/a>\uc758 \uc77c\uc885.<\/p>\n<p>\ubc84\ub4dc\ub098\ubb34 \uaecd\uc9c8\uc740 \uc9c4\ud1b5\ud6a8\uacfc\ub97c \uac00\uc9c0\uace0 \uc788\ub294 \uac83\uc73c\ub85c \uc720\uba85\ud558\ub2e4. \uae30\uc6d0\uc804 400\ub144\uacbd\uc758\u00a0<a class=\"wiki-link-internal\" title=\"\ud788\ud3ec\ud06c\ub77c\ud14c\uc2a4\" href=\"https:\/\/namu.wiki\/w\/%ED%9E%88%ED%8F%AC%ED%81%AC%EB%9D%BC%ED%85%8C%EC%8A%A4\">\ud788\ud3ec\ud06c\ub77c\ud14c\uc2a4<\/a>\uc758 \uc800\uc11c\uc5d0\uc11c \uc5b8\uae09\ub418\uae30\ub3c4 \ud588\uace0, \ub2f9\uc7a5 \uc6b0\ub9ac\ub098\ub77c\uc5d0\uc11c\ub294\u00a0<a class=\"wiki-link-internal\" title=\"\uc774\uc21c\uc2e0\" href=\"https:\/\/namu.wiki\/w\/%EC%9D%B4%EC%88%9C%EC%8B%A0\">\uc774\uc21c\uc2e0<\/a>\u00a0\uc7a5\uad70\uc774 \ubb34\uacfc \uc2dc\ud5d8\uc5d0\uc11c \ub9d0\uc744 \ud0c0\ub2e4 \ub5a8\uc5b4\uc9c0\uc790\u00a0<a class=\"wiki-link-internal\" title=\"\ubc84\ub4dc\ub098\ubb34\" href=\"https:\/\/namu.wiki\/w\/%EB%B2%84%EB%93%9C%EB%82%98%EB%AC%B4\">\ubc84\ub4dc\ub098\ubb34<\/a>\ub85c \uc0c1\ucc98\ub97c \uc2f8\uace0 \ub2e4\uc2dc \uc2dc\ud5d8\uc744 \ubd24\ub2e4\ub294 \uc77c\ud654\uac00 \uc788\uc744 \uc815\ub3c4\ub2c8. \uc774 \uc911\uc5d0\uc11c \uc9c4\ud1b5\ud6a8\uacfc\ub97c \ub0b4\ub294 \ubb3c\uc9c8\uc778 \uc0b4\ub9ac\uc2e0\uc758 \u03b2-\uae00\ub8e8\ucf54\uc2dc\ub4dc \ubd80\ubd84\uc744 \uce74\ubcf5\uc2e4\uc0b0\uc73c\ub85c \uce58\ud658\ud558\uc5ec \uc0b4\ub9ac\uc2e4\uc0b0\uc744 \uc5bb\uace0, \uc0b4\ub9ac\uc2e4\uc0b0\uc758 \uc54c\ucf54\uc62c\uae30\ub97c \uc544\uc138\ud2f8\uae30\ub85c \uce58\ud658\ud55c \uac83\uc774 \uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0, \ud639\uc740 \uc544\uc2a4\ud53c\ub9b0\uc774\ub2e4.<\/p>\n<p>\uadf8 \uacb0\uacfc\ub85c \uc0b0-\uc5fc\uae30 \uad00\uacc4\uac00 \uc0dd\uc131\ub418\uc5b4 \uc0b4\ub9ac\uc2e4\uc0b0\ubcf4\ub2e4 \uc5ec\ub7ec \ubc29\uba74\uc5d0\uc11c \uac1c\uc120\ub41c\ub2e4. \uc544\uc138\ud2b8\uc0b4\ub9ac\uc2e4\uc0b0\uc740 \uc0b0\uc131 \ud658\uacbd\uc778 \uc704\uc5d0\uc11c\ub294 \uc77c\ubc18\uc801\uc778 \uc0c1\ud0dc\ub85c \uc874\uc7ac\ud558\uc9c0\ub9cc, \uc0c1\ub300\uc801\uc73c\ub85c \uc5fc\uae30\uc131\uc778 \uc18c\uc7a5\uc5d0\uc11c\ub294 \ub8e8\uc774\uc2a4 \uc5fc\uae30\uc640 \uce74\ubcf5\uc2e4\uae30\uac00 \ubc18\uc751\ud558\uc5ec \uc218\uc18c\uac00 \ub5a8\uc5b4\uc800\ub098\uac04 \uc774\uc628\ud654 \uc0c1\ud0dc(\uc9dd\uc5fc\uae30)\ub85c \ubcc0\ud615\ub418\uc5b4 \uc6a9\ud574\ub418\uae30 \uc26c\uc6cc\uc9c4\ub2e4. \uadf8 \uacb0\uacfc \uc704\uc5d0\uc11c\ub294 \uc798 \uc6a9\ud574\ub418\uc9c0 \uc54a\uace0 \uc788\ub2e4\uac00, \uc18c\uc7a5\uc5d0\uc11c \uc6a9\ud574\ub418\uba74\uc11c \ube60\ub974\uace0 \ud6a8\uc728\uc801\uc73c\ub85c \ud761\uc218\ub420 \uc218 \uc788\uac8c \uc720\ub3c4\ud55c \uac83\uc774\ub2e4. \ub364\uc73c\ub85c \ud608\uc561\uc740 \uc0c1\ub300\uc801\uc73c\ub85c \uc5fc\uae30\uc131\uc774\uae30 \ub54c\ubb38\uc5d0 \uc544\uc138\ud2b8\uc0b4\ub9ac\uc2e4\uc0b0\uc740 \ud608\uc911\uc5d0\uc11c\ub3c4 \uc8fc\ub85c \uc774\uc628\ud654 \uc0c1\ud0dc\ub85c \ub5a0\ub3cc\uac8c \ub418\uc5b4 \uc138\ud3ec\ub9c9\uc758 \uadf9\uc131 \ubd80\ubd84\uc744 \uc6a9\uc774\ud558\uac8c \ud1b5\uacfc\ud560 \uc218 \uc788\uac8c \ub41c\ub2e4.\u00a0<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#fn-1\" data-original-title=\"\"><span id=\"rfn-1\" class=\"target\"><\/span>[1]<\/a><\/p>\n<p>\uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0\uc740\u00a0<a class=\"wiki-link-internal\" title=\"\uc0b4\ub9ac\uc2e4\uc0b0\" href=\"https:\/\/namu.wiki\/w\/%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0\">\uc0b4\ub9ac\uc2e4\uc0b0<\/a>\uacfc \ub2e4\ub974\uac8c \ud398\ub180\ub958\uc5d0\uc11c \uc77c\uc5b4\ub098\ub294 \uc0b0\ud654\ucca0\uacfc\uc758 \ucc29\uc0c9\ubc18\uc751\uc774 \uc77c\uc5b4\ub098\uc9c0 \uc54a\ub294\ub370 \uc774\ub294 \ud569\uc131 \uacfc\uc815\uc5d0\uc11c \uc0b4\ub9ac\uc2e4\uc0b0\uacfc \uc544\uc138\ud2b8\uc0b0\uc758 \uc5d0\uc2a4\ud130\ud654 \ubc18\uc751\uc73c\ub85c \uc0b4\ub9ac\uc2e4\uc0b0\uc758 \ud558\uc774\ub4dc\ub85d\uc2dc\uae30\uac00 \ubc18\uc751\ud558\uc5ec\uc11c \uc5d0\uc2a4\ud130\uae30\ub85c \ubcc0\ud654\ud588\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n<p>\ub3c5\uc77c\uc758\u00a0<a class=\"wiki-link-internal\" title=\"\ubc14\uc774\uc5d8\" href=\"https:\/\/namu.wiki\/w\/%EB%B0%94%EC%9D%B4%EC%97%98#s-3\">\ubc14\uc774\uc5d8<\/a>\uc0ac\uc5d0\uc11c \uac1c\ubc1c\ud588\uc73c\uba70, \ubc14\uc774\uc5d8\uc758 \uc0c1\ud488\uba85\uc774 \ubc14\ub85c\u00a0<a class=\"wiki-link-internal\" title=\"\uc544\uc2a4\ud53c\ub9b0\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%8A%A4%ED%94%BC%EB%A6%B0\">\uc544\uc2a4\ud53c\ub9b0<\/a>. \uc9c0\uae08\uc740\u00a0<a class=\"wiki-link-internal\" title=\"\ubcf4\ud1b5\uba85\uc0ac\uac00 \ub41c \uace0\uc720\uba85\uc0ac\ub4e4\" href=\"https:\/\/namu.wiki\/w\/%EB%B3%B4%ED%86%B5%EB%AA%85%EC%82%AC%EA%B0%80%20%EB%90%9C%20%EA%B3%A0%EC%9C%A0%EB%AA%85%EC%82%AC%EB%93%A4\">\ubcf4\ud1b5\uba85\uc0ac\uac00 \ub41c \uace0\uc720\uba85\uc0ac\ub4e4<\/a>\uc5d0 \uac00\uae4c\uc6b4 \ub300\uc811\uc744 \ubc1b\ub294\uc9c0\ub77c \ub2e4\ub978 \uc81c\uc57d\uc0ac\uc5d0\uc11c \ub9cc\ub4e0 \uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0 \uc57d\ud488\ub3c4 \uc544\uc2a4\ud53c\ub9b0\uc73c\ub85c \ubd80\ub978\ub2e4. \ucc38\uace0\ub85c \ubc14\uc774\uc5d8\uc758 \uc5f0\uad6c\uc9c4\ub4e4\uc774 \uc0ac\uc6a9\ud55c \uc0b4\ub9ac\uc2e4\uc0b0\uc740 \ubc84\ub4dc\ub098\ubb34\uac00 \uc544\ub2c8\ub77c\u00a0<a class=\"wiki-link-internal\" title=\"\uba54\ub3c4\uc6b0\uc2a4\uc704\ud2b8\" href=\"https:\/\/namu.wiki\/w\/%EB%A9%94%EB%8F%84%EC%9A%B0%EC%8A%A4%EC%9C%84%ED%8A%B8\">\uba54\ub3c4\uc6b0\uc2a4\uc704\ud2b8<\/a><a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#fn-2\" data-original-title=\"\"><span id=\"rfn-2\" class=\"target\"><\/span>[2]<\/a>\ub77c\ub294 \ud5c8\ube0c\uc5d0\uc11c \ucd94\ucd9c\ud55c \uac83\uc744 \uc0ac\uc6a9\ud588\uc5c8\ub2e4.<a class=\"wiki-link-external\" title=\"https:\/\/en.wikipedia.org\/wiki\/Filipendula_ulmaria\" href=\"https:\/\/en.wikipedia.org\/wiki\/Filipendula_ulmaria#Herbal_and_pharmacological\" target=\"_blank\" rel=\"noopener noreferrer\">\ucc38\uc870<\/a>\u00a0\uc7a5\ubbf8\uacfc\uc758 \uc5ec\ub7ec\ud574\uc0b4\uc774\ud480\uc778 \uba54\ub3c4\uc6b0\uc2a4\uc704\ud2b8 \uc5ed\uc2dc \ub2e4\ub7c9\uc758 \uc0b4\ub9ac\uc2e4\uc0b0\uc744 \uc0dd\uc131\ud558\uc5ec \uc720\ub7fd\uc5d0\uc11c \uc9c4\ud1b5\uc81c\ub85c \uc4f0\uc774\ub358 \ud5c8\ube0c\uc600\ub2e4. \uc774 \uba54\ub3c4\uc6b0\uc2a4\uc704\ud2b8\uc758 \uc61b \ud559\uba85\uc778 Spiraea ulmaria\uc5d0\uc11c Aspirin\uc774\ub77c\ub294 \uc774\ub984\uc774 \ud0c4\uc0dd\ud558\uac8c \ub418\uc5c8\ub2e4. \uadf8 \uc678\uc5d0\ub3c4 \ub450\ud1b5 \ud658\uc790\ub4e4\uc758 \uc218\ud638\uc131\uc778\uc774\uba70 \ub098\ud3f4\ub9ac\uc758 \uc8fc\uad50\ub77c\ub294 \uc544\uc2a4\ud53c\ub9ac\ub204\uc2a4\uc758 \uc774\ub984\uc744 \ubd99\uc600\ub2e4\uace0 \ud558\ub294 \uce74\ub354\ub77c\uac00 \uc788\uc73c\ub098, \uadf8\ub7f0 \uc8fc\uad50\ub294 \uc5c6\uc73c\ubbc0\ub85c \uc544\uc2a4\ud53c\ub9b0\uc758 \ub300\uc911\ud654 \uc774\ud6c4\uc5d0 \ub9cc\ub4e4\uc5b4\uc9c4 \uc124\uc778 \ub4ef\ud558\ub2e4. \uc758\ubb38\uc774 \uac04\ub2e4\uba74 \uc9c1\uc811 \u2018\uc544\uc2a4\ud53c\ub9ac\ub178\u2019\ub77c\ub294 \uc131\uc778\uc774 \uc788\ub294\uc9c0\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/maria.catholic.or.kr\/sa_ho\/list\/list.asp?menugubun=saint&amp;today=&amp;today_tmp=&amp;ctxtCommand=&amp;ctxtLogOn=&amp;ctxtSexcode=&amp;ctxtChukday=&amp;ctxtGaladay=&amp;Orggubun=101&amp;ctxtHigh=&amp;ctxtLow=&amp;ctxtChecked=Checked&amp;oldrow=&amp;curpage=1&amp;ctxtOrder=++name1%2Cgaladaym%2Cgaladayd+&amp;ctxtOrderType=&amp;ctxtSaintId=&amp;ctxtSCode=&amp;ctxtSearchNm=\uc544\uc2a4\ud53c\ub9ac\ub178&amp;ctxtChukmm=&amp;ctxtChukdd=&amp;ctxtPosition=&amp;ctxtCity=&amp;PSIZE=20\" href=\"http:\/\/maria.catholic.or.kr\/sa_ho\/list\/list.asp?menugubun=saint&amp;today=&amp;today_tmp=&amp;ctxtCommand=&amp;ctxtLogOn=&amp;ctxtSexcode=&amp;ctxtChukday=&amp;ctxtGaladay=&amp;Orggubun=101&amp;ctxtHigh=&amp;ctxtLow=&amp;ctxtChecked=Checked&amp;oldrow=&amp;curpage=1&amp;ctxtOrder=++name1%2Cgaladaym%2Cgaladayd+&amp;ctxtOrderType=&amp;ctxtSaintId=&amp;ctxtSCode=&amp;ctxtSearchNm=%EC%95%84%EC%8A%A4%ED%94%BC%EB%A6%AC%EB%85%B8&amp;ctxtChukmm=&amp;ctxtChukdd=&amp;ctxtPosition=&amp;ctxtCity=&amp;PSIZE=20\" target=\"_blank\" rel=\"noopener noreferrer\">\uac80\uc0c9\ud574\ubcf4\uc790.<\/a><\/p>\n<p><a class=\"wiki-link-internal\" title=\"19\uc138\uae30\" href=\"https:\/\/namu.wiki\/w\/19%EC%84%B8%EA%B8%B0\">19\uc138\uae30<\/a>\uc778 1899\ub144\uc5d0 \uc774\ubbf8 \uc138\uacc4 \ucd9c\uc2dc\ub97c \ud55c \ubb3c\uac74\uc774\ub2e4. \ud575\uc2ec\u00a0<a class=\"wiki-link-internal\" title=\"\ud2b9\ud5c8\" href=\"https:\/\/namu.wiki\/w\/%ED%8A%B9%ED%97%88\">\ud2b9\ud5c8<\/a>\u00a0\ub530\uc708 \uc774\ubbf8 \ud638\ub791\uc774 \ub2f4\ubc30 \uba39\ub358 \uc2dc\uc808\uc5d0 \ub9cc\ub8cc\ub41c \uc57d\uc774\ub77c\uc11c \uad6d\ub0b4 \uc81c\uc57d\ud68c\uc0ac\uc5d0\uc11c\ub3c4 \uc0dd\uc0b0\ud55c\ub2e4. \ub531\ud788 \uc870\uc81c\ubc95\uc774 \ubcf5\uc7a1\ud55c \uc57d\ubb3c\ub3c4 \uc544\ub2c8\ub77c \uc6ec\ub9cc\ud55c \uc81c\uc57d\uc0ac\ub77c\uba74 \uc544\uc2a4\ud53c\ub9b0\uc740 \uac70\uc758 \ud328\uc2dc\ube0c\ub85c \uc0dd\uc0b0\ud55c\ub2e4\uace0 \ubd10\ub3c4 \uc88b\ub2e4.<\/p>\n<\/div>\n<p class=\"wiki-heading\"><a id=\"s-2\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#toc\">2.<\/a>\u00a0\uc81c\ubc95<\/p>\n<div class=\"wiki-heading-content\">\n<p><a class=\"wiki-link-internal\" title=\"\uace0\ub4f1\ud559\uad50\" href=\"https:\/\/namu.wiki\/w\/%EA%B3%A0%EB%93%B1%ED%95%99%EA%B5%90\">\uace0\ub4f1\ud559\uad50<\/a>\u00a0<a class=\"wiki-link-internal\" title=\"\ud654\ud559\u2161\" href=\"https:\/\/namu.wiki\/w\/%ED%99%94%ED%95%99%E2%85%A1\">\ud654\ud559\u2161<\/a>\uc5d0 \ub098\uc62c \uc815\ub3c4\ub85c \uc81c\ubc95\uc774 \uac04\ub2e8\ud55c\ub370, \uc0b4\ub9ac\uc2e4\uc0b0\uacfc \ubb34\uc218\uc544\uc138\ud2b8\uc0b0 \ub610\ub294 Acetyl chloride\ub97c 70-80\ub3c4, \uc0b0 \uc870\uac74\uc5d0\uc11c \ubc18\uc751\uc2dc\ucf1c \uc5bb\ub294 \uac83\uc774 \uac00\uc7a5 \ucd08\ubcf4\uc801\uc778 \uc81c\ubc95\uc774\ub2e4.\u00a0<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#fn-3\" data-original-title=\"\"><span id=\"rfn-3\" class=\"target\"><\/span>[3]<\/a><\/p>\n<p>\ub610\ud55c\u00a0<a class=\"wiki-link-internal\" title=\"\ubca4\uc820\" href=\"https:\/\/namu.wiki\/w\/%EB%B2%A4%EC%A0%A0\">\ubca4\uc820<\/a>\uc744 \uc774\uc6a9\ud574 \ub9cc\ub4e4\uae30\ub3c4 \ud55c\ub2e4. \ubca4\uc820\uc5d0\u00a0<a class=\"wiki-link-internal\" title=\"\ud669\uc0b0(\ud654\ud559)\" href=\"https:\/\/namu.wiki\/w\/%ED%99%A9%EC%82%B0(%ED%99%94%ED%95%99)\">\ud669\uc0b0<\/a>\uc744 \uac00\ud574 \ubca4\uc820\uc220\ud3f0\uc0b0\uc744 \ub9cc\ub4e0 \ub4a4\u00a0<a class=\"wiki-link-internal\" title=\"\uc218\uc0b0\ud654\ub098\ud2b8\ub968\" href=\"https:\/\/namu.wiki\/w\/%EC%88%98%EC%82%B0%ED%99%94%EB%82%98%ED%8A%B8%EB%A5%A8\">\uc218\uc0b0\ud654\ub098\ud2b8\ub968<\/a>\uc744 \ubca4\uc820\uc220\ud3f0\uc0b0\uc5d0 \uac00\ud574 \ud398\ub180\ub098\ud2b8\ub968\uc744 \ub9cc\ub4e0 \ub4a4, \uac70\uae30\ub2e4\uac00 \uace0\uc628 \uace0\uc555\uc5d0\uc11c<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#fn-4\" data-original-title=\"\"><span id=\"rfn-4\" class=\"target\"><\/span>[4]<\/a>\u00a0\uc774\uc0b0\ud654\ud0c4\uc18c\ub97c \uac00\ud574 \uc0b4\ub9ac\uc2e4\uc0b0\ub098\ud2b8\ub968\uc744 \ub9cc\ub4e0 \ub4a4 \ub2e4\uc2dc \ud669\uc0b0\uc744 \uac00\ud574 \uc0b4\ub9ac\uc2e4\uc0b0\uc744 \ub9cc\ub4e4\uace0, \uc5ec\uae30\uc5d0 \uc0c1\uae30\ud55c \ubb34\uc218\uc544\uc138\ud2b8\uc0b0\uc744 \ubc18\uc751\uc2dc\ud0b4\uc73c\ub85c\uc11c\u00a0<del>\uc228\ucc28\uac8c<\/del>\uc544\uc2a4\ud53c\ub9b0\uc744 \ub9cc\ub4e4\uc5b4\ub0b8\ub2e4.<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#fn-5\" data-original-title=\"\"><span id=\"rfn-5\" class=\"target\"><\/span>[5]<\/a><\/p>\n<\/div>\n<p class=\"wiki-heading\"><a id=\"s-3\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#toc\">3.<\/a>\u00a0\uc57d\ub9ac\uc791\uc6a9<\/p>\n<div class=\"wiki-heading-content\">\n<p><strong><a class=\"wiki-link-internal\" title=\"\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C\">\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c<\/a>,\u00a0<a class=\"wiki-link-internal\" title=\"\uc774\ubd80\ud504\ub85c\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EC%9D%B4%EB%B6%80%ED%94%84%EB%A1%9C%ED%8E%9C\">\uc774\ubd80\ud504\ub85c\ud39c<\/a>\uacfc \ud568\uaed8\u00a0<a class=\"wiki-link-internal\" title=\"\uc9c4\ud1b5\uc81c\" href=\"https:\/\/namu.wiki\/w\/%EC%A7%84%ED%86%B5%EC%A0%9C\">\uc9c4\ud1b5\uc81c<\/a>\uc758\u00a0<a class=\"wiki-link-internal\" title=\"\uc0bc\ub300\uc7a5\" href=\"https:\/\/namu.wiki\/w\/%EC%82%BC%EB%8C%80%EC%9E%A5\">\uc0bc\ub300\uc7a5<\/a>.<\/strong><a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#fn-6\" data-original-title=\"\"><span id=\"rfn-6\" class=\"target\"><\/span>[6]<\/a><\/p>\n<p>\uad6c\uc870\ub294 \uc0c1\ub2f9\ud788 \uac04\ub2e8\ud55c \ubd84\uc790\uc9c0\ub9cc \uc2e4\uc81c \uc57d\ub9ac\uc791\uc6a9\uc740 \ubcf5\uc7a1\ud558\ub2e4. \uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0\uc774 \uc0b4\ub9ac\uc2e4\uc0b0\uc73c\ub85c \ud761\uc218\ub420 \ub54c \ub300\ub1cc\ud53c\uc9c8\ub85c \ud1b5\uc99d\uc744 \uc804\ub2ec\ud558\uace0 \uc5fc\uc99d\uc744 \uc77c\uc73c\ud0a4\ub294 \ubb3c\uc9c8\uc778\u00a0<a class=\"wiki-link-internal\" title=\"\ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518\" href=\"https:\/\/namu.wiki\/w\/%ED%94%84%EB%A1%9C%EC%8A%A4%ED%83%80%EA%B8%80%EB%9E%80%EB%94%98\">\ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518<\/a>\u00a0\ud569\uc131\uc5d0 \uad00\uc5ec\ud558\ub294 COX \ud6a8\uc18c\ub97c \uc800\ud574\ud55c\ub2e4. \uc774\ub294 \ubaa8\ub4e0 NSAIDs\uc758 \uae30\ubcf8\uc801\uc778 \uc791\uc6a9\uc774\ub2e4. \ubb38\uc81c\ub294 COX \ud6a8\uc18c\ub294 \ub450 \uc885\ub958\uac00 \uc788\ub294\ub370 COX-1\uc740 \ud608\uc18c\ud310\uc5d0\ub3c4 \ub4e4\uc5b4\uc788\ub294 \ud6a8\uc18c\ub85c \ud608\uc561\uc751\uace0\uc5d0 \uad00\uc5ec\ud558\ub294\ub370 \uc0b4\ub9ac\uc2e4\uc0b0\uc740 COX-1 \ubc0f COX-2\uc640 \ube44\uc120\ud0dd\uc801\uc73c\ub85c \ube44\uac00\uc5ed\uc801 \uacb0\ud569\uc744 \ud615\uc131\ud558\ubbc0\ub85c \ub2e8\ubc31\uc9c8 \uc7ac\ud569\uc131\uc774 \ubd88\uac00\ub2a5\ud55c \ud608\uc18c\ud310\uc5d0\uc120 \ub2f9\uc5f0\ud788 \ud6a8\uc18c\uac00 \uacb0\ud54d\ub418\ubbc0\ub85c \uc774\ub85c \uc778\ud574 \ud56d\uc751\uace0\uc131\uc774 \uc0dd\uae30\ub294 \uac83\uc774\ub2e4.<\/p>\n<p>\ub530\ub77c\uc11c COX-2\ub9cc \uc791\uc6a9\ud558\ub294 \uc120\ud0dd\uc801 COX-2 \uc791\uc6a9 \uc18c\uc5fc\uc9c4\ud1b5\uc81c \uc81c\uc7ac\ub4e4\uc774 \uac1c\ubc1c\ub418\uace0 \uc788\uc73c\uba70 \uc774\ub294 \uae30\uc874\uc758 NSAIDs\uc5d0 \ube44\ud574 \uc6b0\uc218\ud55c \uc9c4\ud1b5\ud6a8\uacfc\ub97c \ub0bc\uac83\uc73c\ub85c \uae30\ub300\ub418\uc5b4\uc9c0\ub098 \uc6ec\uc77c\uc778\uc9c0 \uc0ac\uace0\uac00 \ud130\uc838\uc11c \uc774\ub4e4 \uc911 \ud558\ub098\uc600\ub358\u00a0<a class=\"wiki-link-internal not-exist\" title=\"\ubc14\uc774\uc625\uc2a4\" href=\"https:\/\/namu.wiki\/w\/%EB%B0%94%EC%9D%B4%EC%98%A5%EC%8A%A4\">\ubc14\uc774\uc625\uc2a4<\/a>, \uc989 \ub85c\ud398\ucf55\uc2ed\uc774 \uc2ec\ud608\uad00\uc5d0 \uce58\uba85\uc801\uc778 \ud53c\ud574\ub97c \uc8fc\ub294 \ucda9\uaca9\uc801\uc778 \uacb0\uacfc\uac00 \ub098\ud0c0\ub0ac\ub2e4. \ub2e4\ub978 \uc81c\uc7ac\uc778 \uc140\ub808\ucf55\uc2ed\uc5d0 \ub300\ud574\uc11c\ub294 \uc544\uc9c1 \uce58\uba85\uc801\uc778 \uc190\uc0c1\uc744 \uc8fc\uc5c8\ub2e4\ub294 \uc784\uc0c1\uacb0\uacfc\uac00 \ubcf4\uace0\ub41c \uacbd\uc6b0\ub294 \uc5c6\ub2e4. \uc804\ubc18\uc801\uc778\u00a0<a class=\"wiki-link-internal\" title=\"NSAID\" href=\"https:\/\/namu.wiki\/w\/NSAID\">NSAID<\/a>\u00a0\uc81c\uc81c\ub4e4\uc5d0 \ub300\ud55c \uc815\ubcf4\ub294\u00a0<a class=\"wiki-link-internal\" title=\"NSAID\" href=\"https:\/\/namu.wiki\/w\/NSAID\">NSAID<\/a>\u00a0\ud56d\ubaa9\uc744 \ucc38\uace0.<\/p>\n<p>\uccb4\ub0b4 \ub3d9\ud0dc\uc5d0 \ub300\ud574\uc11c \ubcf4\uc790\uba74 \uc544\uc2a4\ud53c\ub9b0\uc740 \uc704\uc7a5\uad00\uc5d0\uc11c \ud761\uc218\ub41c \ub4a4 \ubcf4\ud1b5 30\ubd84 \uc774\ub0b4\ub85c \ud761\uc218\ub41c \uc591\uc758 \uc808\ubc18 \uac00\ub7c9\uc774 \ubc30\uc124 \ud639\uc740 \ub300\uc0ac\ub418\uac70\ub098 \ub2e4\ub978 \ud608\uc911 \ub2e8\ubc31\uc9c8\uc5d0 \ubd99\uc5b4\uc11c \uc791\uc6a9\uc774 \uc0ac\ub77c\uc9c4\ub2e4(\uc774\ub97c \uc57d\ub9ac\ud559\uc801 \ud45c\ud604\uc73c\ub85c\ub294 \ubc18\uac10\uae30\uac00 30\ubd84 \ubbf8\ub9cc\uc774\ub77c\uace0 \ud55c\ub2e4). \ud608\uc911 \ub2e8\ubc31\uc9c8(\uc8fc\ub85c \uc54c\ubd80\ubbfc)\uc5d0 \ubd99\uc5b4\ubc84\ub9b0 \uc544\uc2a4\ud53c\ub9b0\uc740 \uc2dc\uac04\uc774 \uc9c0\ub098\uba74\uc11c \uc11c\uc11c\ud788 \ub2e8\ubc31\uc9c8\uc5d0\uc11c \ub5a8\uc5b4\uc838\ub098\uc640\uc11c \ub2e4\uc2dc \uc791\uc6a9\ud558\uac8c \ub41c\ub2e4. \ubcf4\ud1b5 \ub2e8\ubc31\uc9c8\uc5d0 \ubd99\uc740 \uc54c\ubd80\ubbfc\uc774 \ub2e4 \ub5a8\uc5b4\uc9c8 \ub54c\uae4c\uc9c0 7~9\uc77c \uc815\ub3c4 \uac78\ub9b0\ub2e4. \uc774\ub54c \uc11c\uc11c\ud788 \ub098\uc624\ub294 \uc544\uc2a4\ud53c\ub9b0\uc740 \ud56d\uc5fc\uc99d, \uc9c4\ud1b5, \ud574\uc5f4 \uc791\uc6a9\uc744 \ud558\uae30\uc5d0\ub294 \ubd80\uc871\ud558\uace0, \ud56d\uc751\uace0 \uc791\uc6a9\uc744 \uc8fc\ub85c \ud55c\ub2e4. \ub2e4\uc2dc \ub9d0\ud574 \uc544\uc2a4\ud53c\ub9b0\uc740 \uba39\uc740 \ub4a4 \uc7a5\uae30\uac04\uc5d0 \uac78\uccd0 \ud608\uc561 \ud56d\uc751\uace0 \ud6a8\uacfc\uac00 \ub098\ud0c0\ub09c\ub2e4. \uc2dc\uc911\uc5d0 \ud310\ub9e4\ub418\ub294 \uc57d\ub4e4\uc774 \ud558\ub8e8\uc5d0 \ud558\ub098\uc529 \uba39\ub3c4\ub85d \ub418\uc5b4 \uc788\ub294 \uc774\uc720\ub294 \uc6d0\ud558\ub294 \ud6a8\uacfc\uac00 \ubc1c\ud718\ub418\uae30\uc5d0 \ucda9\ubd84\ud55c \ud608\uc911 \uc544\uc2a4\ud53c\ub9b0 \ub18d\ub3c4\ub97c \uc720\uc9c0\ud558\uae30 \uc704\ud574\uc11c\ub2e4.<\/p>\n<\/div>\n<p class=\"wiki-heading\"><a id=\"s-4\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#toc\">4.<\/a>\u00a0\ubd80\uc791\uc6a9<\/p>\n<div class=\"wiki-heading-content\">\n<p>\uc544\uc2a4\ud53c\ub9b0\uc774 \uac00\uc9c4 \uac00\uc7a5 \ud070 \ubd80\uc791\uc6a9\uc740\u00a0<strong>\ud56d\uc751\uace0<\/strong>\u00a0\uc131\uc9c8\uc774\ub2e4.<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#fn-7\" data-original-title=\"\"><span id=\"rfn-7\" class=\"target\"><\/span>[7]<\/a>\u00a0\uc774\uac74 NSAIDs \uc911\uc5d0\uc11c\ub3c4 \uc544\uc2a4\ud53c\ub9b0\uc774 \uc720\ub3c5 \ud2b9\uc774\ud55c \uc774\uc720\uc774\uae30\ub3c4 \ud558\ub2e4. \uc544\uc2a4\ud53c\ub9b0\uc758 \uad34\ub784\ud55c \ud65c\uc6a9\uc774 \uc774 \ud56d\uc751\uace0 \uc791\uc6a9\uc5d0 \uc0c1\ub2f9\ud788 \ub9ce\uc774 \uae30\ub300\uace0 \uc788\uc9c0\ub9cc, \uc774 \ud56d\uc751\uace0 \uc791\uc6a9\uc740 \ubd80\ub2f4\uc2a4\ub7ec\uc6b4 \ubd80\uc791\uc6a9\uc774\uae30\ub3c4 \ud558\ub2e4. \uc544\uc2a4\ud53c\ub9b0 \ub9ce\uc774 \uba39\ub358 \uc0ac\ub78c\uc774 \ucf54\ud53c \ud758\ub9ac\uba74 \ud53c\uac00 \uc880\ucc98\ub7fc \uc548 \uba4e\ub294\ub2e4.<\/p>\n<p>\uc774 \ud2b9\uc131 \ub54c\ubb38\uc5d0 \ucd9c\ud608\uc744 \ub3d9\ubc18\ud55c \uc678\/\ub0b4\uc0c1 \ud658\uc790\uc5d0\uac8c \uc9c4\ud1b5\uc81c\ub85c \ucc98\ubc29\ud558\uae30\uac00 \uace4\ub780\ud55c \ud3b8. \ud1b5\uc99d \uc7a1\uc73c\ub824\ub2e4 \ucd9c\ud608\uc744 \ub354\uc6b1 \uc545\ud654\uc2dc\ud0ac \uc218 \uc788\uae30 \ub54c\ubb38\uc774\ub2e4. \ub610\ud55c \ud56d\uc751\uace0 \uc791\uc6a9\uc5d0 \uc758\ud55c \ucd9c\ud608 \uc545\ud654\ub294\u00a0<strong>\uc704\uada4\uc591\uc744 \uc720\ubc1c\ud558\uac70\ub098, \uc774\ubbf8 \ubc1c\uc0dd\ud55c \uc704\uada4\uc591\uc744 \uc545\ud654<\/strong>\uc2dc\ud0ac \uc218 \uc788\ub2e4. \uc704\uc554 \ud658\uc790\uac00 \uc544\uc2a4\ud53c\ub9b0\uc744 \uc12d\ucde8\ud560 \uc2dc\uc5d0\ub294 \ub0b4\ucd9c\ud608\ub85c \uc0ac\ub9dd\ud560 \uc218 \uc788\uc73c\uba70 \uc544\uc2a4\ud53c\ub9b0 \uc790\uccb4\ub3c4 \uc57d\uc0b0\uc774\uae34 \ud574\ub3c4 \uc0b0\uc131\uc774\uae30\uc5d0\u00a0<strong>\uc704\uada4\uc591 \uc720\ubc1c \ubc0f \uc545\ud654\ub294 \uc544\uc2a4\ud53c\ub9b0\uc758 \ubd80\uc815\uc801\uc778 \uc791\uc6a9\uc758 \uac04\ud310<\/strong>\uc73c\ub85c \uc790\ub9ac\uc7a1\uc558\ub2e4. \uc774 \ubb38\uc81c\ub97c \ud574\uacb0\ud558\uae30 \uc704\ud574, \uc18c\ud654\uae30\uad00 \uc18d\uc5d0\uc11c \uc644\ucda9\uc6a9\uc561\ucc98\ub7fc \ub418\uac8c\ub054 \ub2e4\ub978 \ubb3c\uc9c8\uc744 \uc11e\uc5b4 \ub123\uc740 \uc81c\ud488\ub4e4\uc774 \uc0dd\uc0b0\ub418\uace0 \uc788\uc73c\uba70, \uc544\uc608 \uc704\uc5d0\uc11c \uc544\uc2a4\ud53c\ub9b0\uc774 \uc720\ucd9c\ub418\uc9c0 \uc54a\ub3c4\ub85d \ud504\ub85c\ud14d\ud2b8 \uc815\uc774\ub77c\ub294 \uc81c\ud488\ub3c4 \ub098\uc654\ub2e4. \ucd5c\uadfc\uc5d0 \ub098\uc628 \uc544\uc2a4\ud53c\ub9b0\uc740 \uc8c4\ub2e4 \uc644\ucda9\ub418\uc5b4 \uc788\ub294 \uc81c\ud488\ub4e4\uc774\uc9c0\ub9cc \ub0a1\uc740 \uac83\uc774\ub77c\uba74 \uc544\ub2d0 \uc218\ub3c4 \uc788\uc73c\ub2c8 \uc8fc\uc758. \uadf8\ub9ac\uace0 \uc644\ucda9\uc744 \uc704\ud574 \uac19\uc774 \ub4e4\uc5b4\uac04 \uc131\ubd84\ub4e4\uc774 \uc2dc\uac04\uc774 \uc9c0\ub098\uba74\uc11c \uc904\uc5b4\uc11c \uc81c\ub300\ub85c \uc644\ucda9\uc791\uc6a9\uc744 \ud558\uc9c0 \ubabb\ud558\ub294 \uacbd\uc6b0\ub3c4 \uc788\ub2e4.<\/p>\n<p>\uc544\uc2a4\ud53c\ub9b0\uc758 \uacbd\uc6b0 \uc880 \ud2b9\uc774\ud558\uac8c \uc2e0\uc7a5\uc758 \uc0b0\uc131\ub3c4\ub97c \ubcc0\uacbd\uc2dc\ud0ac \uc218 \uc788\ub294\ub370, \uc774\ub85c \uc778\ud574\u00a0<strong>\uc2e0\uc7a5\uc5d0\uc11c\u00a0<a class=\"wiki-link-internal\" title=\"\uc694\uc0b0\" href=\"https:\/\/namu.wiki\/w\/%EC%9A%94%EC%82%B0\">\uc694\uc0b0<\/a>\uc758 \ubc30\uc124\uc744 \uc5b4\ub835\uac8c \ub9cc\ub4e4\uc5b4 \uc694\uc0b0 \ucd95\uc801\uc73c\ub85c\u00a0<a class=\"wiki-link-internal\" title=\"\ud1b5\ud48d\" href=\"https:\/\/namu.wiki\/w\/%ED%86%B5%ED%92%8D\">\ud1b5\ud48d<\/a>\uc774 \uc2ec\ud574\uc9c8 \uc218 \uc788\ub2e4.<\/strong>\u00a0\ud1b5\ud48d\uc774 \uc5c6\ub2e4\uac00 \uc0dd\uae38 \uc815\ub3c4\ub294 \uc544\ub2c8\uc9c0\ub9cc \uc774\ubbf8 \ud1b5\ud48d\uc774 \uc788\ub294 \ud658\uc790\uc5d0\uac8c\ub294 \uc4f0\uba74 \uc548 \ub420 \uc815\ub3c4\ub77c\uace0 \ubcf4\uba74 \ub41c\ub2e4.<\/p>\n<p>\ub9cc 18\uc138 \ubbf8\ub9cc\uc758 \uc5b4\ub9b0\uc774 \ubc0f \uccad\uc18c\ub144\uc774 \ubcf5\uc6a9 \ud558\uba74 \uc2ec\uac01\ud55c \ub1cc\uc190\uc0c1\uacfc \uac04\uc190\uc0c1\uc744 \uc77c\uc73c\ud0a4\ub294\u00a0<a class=\"wiki-link-internal\" title=\"\ub77c\uc774 \uc99d\ud6c4\uad70\" href=\"https:\/\/namu.wiki\/w\/%EB%9D%BC%EC%9D%B4%20%EC%A6%9D%ED%9B%84%EA%B5%B0\">\ub77c\uc774 \uc99d\ud6c4\uad70<\/a>\uc774 \ubc1c\uc0dd\ud560 \uc218 \uc788\uc73c\ubbc0\ub85c, \uc77c\ubc18 \uc544\uc2a4\ud53c\ub9b0\uc740 \ub9cc 14\uc138 \ubbf8\ub9cc\uc758 \uc5b4\ub9b0\uc774\uc5d0\uac90 \uc808\ub300 \ud22c\uc57d\ud558\uc9c0 \ub9d0\uc544\uc57c\ud55c\ub2e4. \uc5b4\ub9b0\uc774\uc6a9\uc73c\ub860 \uc774\ubd80\ud504\ub85c\ud39c\uc774\ub098 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uacfc \uac19\uc740 \ub300\uccb4\uc81c\ub97c \uc774\uc6a9\ud560 \uac83. \uc6a9\ub7c9\uc744 \uc904\uc774\ub294 \ub4f1\uc758 \ucc98\ub9ac\ub97c \ud55c \uc5b4\ub9b0\uc774\uc6a9 \uc544\uc2a4\ud53c\ub9b0\ub3c4 \uc788\ub2e4. \ud558\uc9c0\ub9cc \uc560\ucd08\uc5d0 \ub77c\uc774 \uc99d\ud6c4\uad70\uc774 \ubc1c\ubcd1\ud560 \ud655\ub960\uc774 \ub9e4\uc6b0\ub9e4\uc6b0 \ub0ae\ub2e4.<\/p>\n<p>\uc77c\ub2e8 \uae30\ubcf8\uc801\uc73c\ub85c NSAID \uacc4\uc5f4\ubbc0\ub85c \uc544\uc2a4\ud53c\ub9b0\uc131 \ucc9c\uc2dd\ub3c4 \uc885\uc885 \uc720\ubc1c\ud55c\ub2e4. \uad6c\uccb4\uc801 \uc791\uc6a9\uae30\uc804\uc740\u00a0<a class=\"wiki-link-internal\" title=\"NSAID\" href=\"https:\/\/namu.wiki\/w\/NSAID\">NSAID<\/a>\u00a0\ubb38\uc11c\uc758 \ubd80\uc791\uc6a9 \ubd80\ubd84\uc744 \ubcfc \uac83. \ud658\uc790\uc5d0 \uc0c1\ud0dc\uc5d0 \ub530\ub77c \ub2e4\ub974\uc9c0\ub9cc \uc2ec\ud558\uba74 \uc9c8\uc2dd\uc73c\ub85c \uc778\ud574 \uc0ac\ub9dd\uae4c\uc9c0 \ud560 \uc218 \uc788\uae30 \ub54c\ubb38\uc5d0 \uc870\uc2ec\ud560 \uac83. \uc774\uba85(\uadc0\uc6b8\uc74c) \ub610\ud55c \uc740\uadfc\ud788 \ud754\ud55c \ubd80\uc791\uc6a9\uc774\ub2c8 \uc8fc\uc758 \ud560\uac83.<\/p>\n<p><a class=\"wiki-link-internal\" title=\"\uc219\ucde8\" href=\"https:\/\/namu.wiki\/w\/%EC%88%99%EC%B7%A8\">\uc219\ucde8<\/a>\uc5d0 \uc77c\uc5b4\ub098\ub294\u00a0<a class=\"wiki-link-internal\" title=\"\ub450\ud1b5\" href=\"https:\/\/namu.wiki\/w\/%EB%91%90%ED%86%B5\">\ub450\ud1b5<\/a>\u00a0\uc7a1\uaca0\ub2e4\uace0 \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\ub294 \uac83\ub3c4 \ub418\ub3c4\ub85d \uc0bc\uac00\ub294 \uac8c \uc88b\ub2e4. \uc54c\ucf54\uc62c\ub85c \uc57d\ud574\uc9c4 \uc704\uc5d0 \ub354 \ucda9\uaca9\uc744 \uc8fc\uc5b4\uc11c \uc704\ucd9c\ud608\uc774 \uc77c\uc5b4\ub0a0 \uc218\ub3c4 \uc788\ub2e4. \uadf8\ub807\ub2e4\uace0 \ub2e4\ub978 \uc9c4\ud1b5\uc81c\uc778\u00a0<a class=\"wiki-link-internal\" title=\"\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C\">\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c<\/a>(\ud0c0\uc774\ub808\ub180)\uc744 \ubcf5\uc6a9\ud558\ub294 \uac74 \ub354\ub354\uc6b1 \ud53c\ud574\uc57c \ud55c\ub2e4. \uc774\ucabd\uc740 \uac04\uc5d0 \uce58\uba85\uc801\uc774\uae30 \ub54c\ubb38\uc774\ub2e4. \uc0ac\uc2e4 \uc219\ucde8\ub85c \uc77c\uc5b4\ub098\ub294 \ub450\ud1b5\uc740 \uc774\ub7ec\ud55c \ubd80\uc791\uc6a9 \ub54c\ubb38\uc5d0 \uac00\uc815\uc6a9 \uc9c4\ud1b5\uc81c\ub294 \uace4\ub780\ud558\uace0, \uadf8\ub0e5 \ud734\uc2dd\uc744 \ucde8\ud558\uba70 \uc790\uc5f0 \uce58\uc720\ub418\uae38 \uae30\ub2e4\ub9ac\ub294\uac8c \ub354 \ub0ab\ub2e4. \uc815 \uc2ec\ud558\uba74 \ubcd1\uc6d0\uc5d0 \uac00\uc11c \ub530\ub85c \ucc98\ubc29\ubc1b\uc544\uc57c \ud55c\ub2e4.<\/p>\n<p>\uc7a5\uae30 \ubcf5\uc6a9\ud558\ub294 \uacbd\uc6b0, \ud608\uc815\uc561\uc99d\uc774 \ubc1c\uc0dd\ud560 \uc218 \uc788\ub2e4.<a class=\"wiki-link-external\" title=\"http:\/\/www.koreahealthlog.com\/?p=8740\" href=\"http:\/\/www.koreahealthlog.com\/?p=8740\" target=\"_blank\" rel=\"noopener noreferrer\">#<\/a><\/p>\n<\/div>\n<p class=\"wiki-heading\"><a id=\"s-5\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#toc\">5.<\/a>\u00a0\uc544\uc2a4\ud53c\ub9b0\uc758 \uc7ac\ubc1c\uacac<\/p>\n<div class=\"wiki-heading-content\">\n<p><strong>\uc758\uc57d\ud488\uc758 \uac00\uc131\ube44 \uc655, \ud604\ub300\ubb38\uba85\uc774 \ub0b3\uc740\u00a0<a class=\"wiki-link-internal\" title=\"\ub9cc\ubcd1\ud1b5\uce58\uc57d\" href=\"https:\/\/namu.wiki\/w\/%EB%A7%8C%EB%B3%91%ED%86%B5%EC%B9%98%EC%95%BD\">\ub9cc\ubcd1\ud1b5\uce58\uc57d<\/a><\/strong>.<br \/>\n\uc9c0\uae08\uae4c\uc9c0 \ubc1d\ud600\uc9c4 \ud6a8\ub2a5\uc744 \ubcf4\uba74 \uc591\uc57d\uc774\ub77c\uae30 \ubcf4\ub2e4\ub294 \ubb34\uc2a8 \ud55c\uc57d\uc2a4\ub7fd\ub2e4. \uc544\uc138\ud2b8 \uc2e4\ub9ac\uc2e4\uc0b0\uc740 (\uc5b4\uca50\uc9c0 \ud55c\uc758\ud559\uc2a4\ub7fd\uac8c) \uc5f4\uc744 \ub0ae\ucd94\ub294 \uc57d\uc73c\ub85c \ud0c1\uc6d4\ud55c \ud6a8\ub2a5\uc744 \ubcf4\uc778\ub2e4. \ub2e8\uc21c \uc9c4\ud1b5\/\ud574\uc5f4 \ud6a8\uacfc\uc5d0\uc120 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uacfc \uc774\ubd80\ud504\ub85c\ud39c\uc5d0\u00a0<strong>\ub9e4\uc6b0<\/strong>\u00a0\ub4a4\ub5a8\uc5b4\uc9c0\uc9c0\ub9cc, \uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0\uc740 \ud56d\uc5fc\uc99d, \ud56d\ubc1c\uc5f4, \ud56d\uc751\uace0\ub77c\ub294 3\uac00\uc9c0 \uc8fc\uc694 \ud6a8\uacfc\ub4e4\uc774 \ud76c\ud55c\ud55c \uc2dc\ub108\uc9c0\ub97c \uc774\ub8e8\uba74\uc11c \ub2e4\ub978 NSAIDs\ub4e4\uc740 \ubabb \ud558\ub294 \uc628\uac16 \ud574\uad34\ud55c \ud65c\uc6a9\uc744 \ucc3d\uc870\ud574\ub0b4\uace0 \uc788\uc5b4 \ub2e4\ub978 NSAIDs\uc5d0\uac8c \ubc00\ub824 \ubb3b\ud788\ub2e4\uac00 \ub2e4\uc2dc \uac01\uad11\ubc1b\ub294 \uc911\uc774\ub2e4. \ucd5c\uadfc\uc5d0\ub294 \ud56d\uc554\uc81c\ub85c \uc791\uc6a9\uc774 \uac00\ub2a5\ud558\ub2e4\ub294 \uc5f0\uad6c\ub3c4 \ub098\uc624\uace0 \uc788\ub294\uc9c0\ub77c \ud574\uad34\ud560 \uc815\ub3c4\uc758 \ubc94\uc6a9\uc131\uc774 \ub05d\uc5c6\uc774 \ud655\uc7a5\ub418\ub294 \uc911.\u00a0<del>\uba74\uc8c4\ubd80 \ubc1b\uc740 \ubaa8\ub974\ud540<\/del><\/p>\n<p>\uc544\uc2a4\ud53c\ub9b0\uc740 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c(NSAID \uc544\ub2d8)\uacfc \uc774\ubd80\ud504\ub85c\ud39c\ub4f1\uc758 \ub2e4\ub978 NSAIDs\uc5d0 \ube44\ud574 \ud574\uc5f4\uc9c4\ud1b5 \ud6a8\uacfc\uac00 \ud604\uc800\ud788 \ub5a8\uc5b4\uc9c0\uae30 \ub54c\ubb38\uc5d0 \uacbd\uc7c1\uc790\ub4e4\uc758 \ub4f1\uc7a5\uacfc \ud568\uaed8, \uc544\uc2a4\ud53c\ub9b0\uc758 \uc81c\uc77c \ud070 \uc57d\uc810\uc778 \ud56d\uc751\uace0\uc791\uc6a9\uc73c\ub85c \uc778\ud55c \uc704\uada4\uc591 \uc720\ubc1c\ub85c \uc778\ud574\u00a0<a class=\"wiki-link-internal\" title=\"\uadf8\ub807\uac8c \uc0dd\uac01\ud558\ub358 \uc2dc\uae30\uac00 \uc800\uc5d0\uac8c\ub3c4 \uc788\uc5c8\uc2b5\ub2c8\ub2e4\" href=\"https:\/\/namu.wiki\/w\/%EA%B7%B8%EB%A0%87%EA%B2%8C%20%EC%83%9D%EA%B0%81%ED%95%98%EB%8D%98%20%EC%8B%9C%EA%B8%B0%EA%B0%80%20%EC%A0%80%EC%97%90%EA%B2%8C%EB%8F%84%20%EC%9E%88%EC%97%88%EC%8A%B5%EB%8B%88%EB%8B%A4\">\ube44\uc8fc\ub958(?) \uc57d\ubb3c\ub85c \uc804\ub77d\ud558\ub294 \ub4ef<\/a>\u00a0<a class=\"wiki-link-internal\" title=\"\ud574\uce58\uc6e0\ub098\" href=\"https:\/\/namu.wiki\/w\/%ED%95%B4%EC%B9%98%EC%9B%A0%EB%82%98\">\ud558\uc600\uc73c\ub098&#8230;<\/a>\u00a0<strong>\uc544\uc2a4\ud53c\ub9b0\uc758 \ud56d\uc751\uace0 \uc791\uc6a9\uc758 \uc774\uc810\uc774 \uc7ac\ubc1c\uacac<\/strong>\ub418\uba74\uc11c\u00a0<a class=\"wiki-link-internal\" title=\"\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C\">\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c<\/a>, \ube44\uc544\uadf8\ub77c,\u00a0<a class=\"wiki-link-internal\" title=\"\ud3ec\ube44\ub3c8 \uc694\uc624\ub4dc\" href=\"https:\/\/namu.wiki\/w\/%ED%8F%AC%EB%B9%84%EB%8F%88%20%EC%9A%94%EC%98%A4%EB%93%9C\">\ud3ec\ube44\ub3c8 \uc694\uc624\ub4dc<\/a>,\u00a0<a class=\"wiki-link-internal\" title=\"\uc774\ubd80\ud504\ub85c\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EC%9D%B4%EB%B6%80%ED%94%84%EB%A1%9C%ED%8E%9C\">\uc774\ubd80\ud504\ub85c\ud39c<\/a>(\ud1b5\uc99d \uc5b5\uc81c\uba74\uc5d0\uc11c\ub294 \uc774\ubd80\ube0c\ub85c\ud39c\uacfc \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774 \uc544\uc2a4\ud53c\ub9b0\ubcf4\ub2e4 \ub0ab\ub2e4.)\uc5d0 \ubc84\uae08\uac00\ub294, \uc5b4\uca4c\uba74 \ub2a5\uac00\ud560 \uac83 \uac19\uc740 \uc57d\uc73c\ub85c \ub3cc\ubcc0\ud558\uc600\ub2e4.<\/p>\n<p>\uc544\uc2a4\ud53c\ub9b0\uc758 \ud56d\uc751\uace0 \uc791\uc6a9\uc744 \uc774\uc6a9\ud558\uc5ec \uc2ec\ud608\uad00 \uc9c8\ud658 \uc608\ubc29\uc81c\ub85c \uc0ac\uc6a9\ud558\ub294 \ud65c\uc6a9\ubc95\uc774 \ubc1c\uacac\ub418\ub354\ub2c8, \uadf8 \ubc16\uc5d0 \uc758\uc0ac\uc758 \ucc98\ubc29\uc744 \ubc1b\uace0 \uc815\ub7c9 \ubcf5\uc6a9 \uc2dc \uc544\uc2a4\ud53c\ub9b0\uc774 \ud608\uc555\uc744 \ub0ae\ucdb0\uc8fc\uace0 \uc2ec\uc7a5\uc9c8\ud658\uc5d0 \ud6a8\uacfc\uac00 \uc788\uc73c\uba70, \uc784\uc0b0\ubd80\uc758 \ucd9c\uc0b0\uc5d0\ub3c4 \ub3c4\uc6c0\uc774 \ub41c\ub2e4\ub294 \uc5f0\uad6c \uacb0\uacfc\uc5d0,\u00a0<strong>\ucd5c\uadfc\uc5d4 \uac01\uc885 \uc554 \uc5b5\uc81c\uc791\uc6a9<\/strong>\uc774 \uc788\ub2e4\ub294 \uc5f0\uad6c\uae4c\uc9c0 \ub098\uc654\ub2e4.\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/www.sciencetimes.co.kr\/?p=143363&amp;post_type=news\" href=\"http:\/\/www.sciencetimes.co.kr\/?p=143363&amp;post_type=news\" target=\"_blank\" rel=\"noopener noreferrer\">#<\/a>,\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/www.yonhapnews.co.kr\/bulletin\/2016\/03\/04\/0200000000AKR20160304046400009.HTML?input=1179m\" href=\"http:\/\/www.yonhapnews.co.kr\/bulletin\/2016\/03\/04\/0200000000AKR20160304046400009.HTML?input=1179m\" target=\"_blank\" rel=\"noopener noreferrer\">\uc2dd\ub3c4\uc554, \uc704\uc554, \ub300\uc7a5\uc554<\/a>,\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/www.yonhapnews.co.kr\/bulletin\/2016\/03\/08\/0200000000AKR20160308044200009.HTML?input=1179m\" href=\"http:\/\/www.yonhapnews.co.kr\/bulletin\/2016\/03\/08\/0200000000AKR20160308044200009.HTML?input=1179m\" target=\"_blank\" rel=\"noopener noreferrer\">\uc804\ub9bd\uc120\uc554<\/a>,\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/media.daum.net\/life\/newsview?newsId=20161221102533388&amp;RIGHT_LIFE=R7\" href=\"http:\/\/media.daum.net\/life\/newsview?newsId=20161221102533388&amp;RIGHT_LIFE=R7\" target=\"_blank\" rel=\"noopener noreferrer\">\ucdcc\uc7a5\uc554<\/a>,\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/www.yonhapnews.co.kr\/bulletin\/2017\/07\/21\/0200000000AKR20170721056800017.HTML\" href=\"http:\/\/www.yonhapnews.co.kr\/bulletin\/2017\/07\/21\/0200000000AKR20170721056800017.HTML\" target=\"_blank\" rel=\"noopener noreferrer\">\uac04\uc554<\/a>\u00a0<del>\uc774\ucbe4 \ub418\uba74 \uc758\uc57d\ud488\uacc4\uc758\u00a0<a class=\"wiki-link-internal\" title=\"WD40\" href=\"https:\/\/namu.wiki\/w\/WD40\">WD40<\/a><\/del><\/p>\n<p>\uc544\uc2a4\ud53c\ub9b0 \uc7a5\uae30 \ubcf5\uc6a9\uc790\uac00 \uc704\uc554 \ubc1c\ubcd1\ub960\uc774 \ub0ae\ub2e4\ub294 \uae30\uc0ac\ub3c4 \ub098\uc654\ub2e4.<a class=\"wiki-link-external\" title=\"http:\/\/www.yonhapnews.co.kr\/bulletin\/2018\/06\/21\/0200000000AKR20180621062500017.HTML?input=1179m\" href=\"http:\/\/www.yonhapnews.co.kr\/bulletin\/2018\/06\/21\/0200000000AKR20180621062500017.HTML?input=1179m\" target=\"_blank\" rel=\"noopener noreferrer\">\uc5f0\ud569\ub274\uc2a4 \uad00\ub828 \uae30\uc0ac<\/a><\/p>\n<p>\ud611\uc2ec\uc99d\uc774\ub098 \uc2ec\uadfc\uacbd\uc0c9 \ub4f1 \uc2ec\ud608\uad00\uacc4 \uc9c8\ud658\uc758 \uc704\ud5d8\uc774 \ub192\uc740 \uace0\uc704\ud5d8\uad70 \ud658\uc790(\ube44\ub9cc, \uace0\ub839, \uc2ec\uc7a5 \ubcd1\ub825, \uace0\ud608\uc555, \uace0\uc9c0\ud608\uc99d, \ub1cc\uc878\uc911 \ub4f1 \ud608\uc804\uc9c8\ud658 \uc704\ud5d8\uc790)\ub294 80-100mg \uc815\ub3c4\uc758 \uc544\uc2a4\ud53c\ub9b0\uc744 \ub9e4\uc77c \uc815\uae30\uc801\uc73c\ub85c \ubcf5\uc6a9\ud558\ub294 \uac83\uc774 \uc2ec\uc7a5 \ubc1c\uc791\uc774\ub098 \ud608\uc804\uc758 \uc704\ud5d8\uc744 \ud06c\uac8c \uc904\uc77c \uc218 \uc788\ub2e4\uace0 \ud55c\ub2e4. \uc774\ub7ec\ud55c \uc6a9\ubc95\uc5d0 \uc4f0\uae30 \uc704\ud574 \uc800\uc6a9\ub7c9 \uc544\uc2a4\ud53c\ub9b0 \ud504\ub85c\ud14d\ud2b8 (\uc6a9\ub7c9\uc744 \uc904\uc774\uace0 \uc7a5\uc5d0\uc11c \ub179\uc544 \uc704\uc7a5 \ubd80\ub2f4\uc744 \uc904\uc778 \uc7a5\uc6a9\uc815)\ub3c4 \ub098\uc628\ub2e4. \uc800\uc6a9\ub7c9 \uc544\uc2a4\ud53c\ub9b0 \uc7a5\uc6a9\uc815\uc758 \uac00\uaca9\uc740 \ub300\ucda9 \uac1c\ub2f9 \ucd5c\uc800 33\uc6d0~77\uc6d0 \uc815\ub3c4\ub85c \uc77c\ubc18 \uc544\uc2a4\ud53c\ub9b0\ubcf4\ub2e4 \uc0c1\ub2f9\ud788 \uc2f8\ub2e4. \uc601\uc9c4\uc81c\uc57d \uc601\uc9c4\uc544\uc2a4\ud53c\ub9b0, \uad6c\uc8fc\uc81c\uc57d \uc544\uc2a4\ud30c\uc774\uc5b4 \ucea1\uc290, \ud55c\ub3c5 \ud2b8\ub86c\ud53c\ub9b0\uc815 \ub4f1\uc774 34\uc6d0\ub300\uc758 \ucd5c\uc800\uac00.<\/p>\n<p>2017\ub144 12\uc6d4\uc5d0\ub294 \ud3d0\uae30\uc885\uc758 \uc9c4\ud589\uc744 \uc5b5\uc81c\ud558\ub294 \ud6a8\uacfc\uac00 \uc788\ub2e4\ub294 \uc5f0\uad6c \uacb0\uacfc\ub3c4 \ub098\uc654\ub2e4.\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/www.yonhapnews.co.kr\/bulletin\/2017\/12\/25\/0200000000AKR20171225024000009.HTML\" href=\"http:\/\/www.yonhapnews.co.kr\/bulletin\/2017\/12\/25\/0200000000AKR20171225024000009.HTML\" target=\"_blank\" rel=\"noopener noreferrer\">#<\/a><\/p>\n<p>\uc758\uc678\ub85c \ubc30<a class=\"wiki-link-internal\" title=\"\uba40\ubbf8\" href=\"https:\/\/namu.wiki\/w\/%EB%A9%80%EB%AF%B8\">\uba40\ubbf8<\/a>\uc5d0 \ud6a8\uacfc\uac00 \uc788\ub2e4. \uc815\ub7c9 \ubcf5\uc6a9\ud558\uba74 \ub450\ud1b5\uc774 \uc0ac\ub77c\uc9c0\uba74\uc11c \ud604\uae30\uc99d\ub3c4 \uc904\uc5b4\ub4e4\uace0, \ubb34\ub9ac\ud558\uac8c \ubab8\uc744 \uc6c0\uc9c1\uc774\uc9c0 \uc54a\ub294 \ud55c \uadf8\ub7ed\uc800\ub7ed \ubc84\ud2f8 \ub9cc\ud55c \uc0c1\ud0dc\uac00 \ub41c\ub2e4.\u00a0<a class=\"wiki-link-internal\" title=\"\uace0\uc0b0\ubcd1\" href=\"https:\/\/namu.wiki\/w\/%EA%B3%A0%EC%82%B0%EB%B3%91\">\uace0\uc0b0\ubcd1<\/a>\uc5d0\ub3c4 \ud6a8\uacfc\uac00 \uc788\ub2e4.<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#fn-8\" data-original-title=\"\"><span id=\"rfn-8\" class=\"target\"><\/span>[8]<\/a>\u00a0\uadf8\ub7ec\ub098 \uc5f0\uad6c \uc790\uccb4\uac00 \uba87 \uc5c6\uace0 \ud6a8\uacfc\ub3c4 \uc81c\ud55c\uc801\uc774\uba70 \uaca8\uc6b0 \uace0\ub3c4 3500m\uc5d0\uc11c \ubcf4\uace0\ub41c \ub0b4\uc6a9\uc774\ub2e4. \uacfc\uc2e0\uc740 \ub9d0\uc790.<\/p>\n<p>\ubc1c\uae30\ubd80\uc804\uc5d0\ub3c4 \ud6a8\uacfc\uac00 \uc788\ub294\ub4ef \ud558\ub2e4.\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/m.news.naver.com\/read.nhn?mode=LSD&amp;mid=sec&amp;sid1=103&amp;oid=296&amp;aid=0000034673\" href=\"http:\/\/m.news.naver.com\/read.nhn?mode=LSD&amp;mid=sec&amp;sid1=103&amp;oid=296&amp;aid=0000034673\" target=\"_blank\" rel=\"noopener noreferrer\">#<\/a><\/p>\n<p>\uacb0\uad6d \uc544\uc2a4\ud53c\ub9b0\uc758 \ubd80\uc791\uc6a9\uc778 \ud56d\uc751\uace0 \uc791\uc6a9\uc740\u00a0<strong>\ub3c5\uc774 \ub418\uae30\ub3c4 \ud558\uace0<\/strong><a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#fn-9\" data-original-title=\"\"><span id=\"rfn-9\" class=\"target\"><\/span>[9]<\/a>\u00a0<strong>\uc57d\uc774 \ub418\uae30\ub3c4 \ud558\ub294 \uc591\ub0a0\uc758 \uce7c<\/strong>\ub85c\uc368, \uc544\uc2a4\ud53c\ub9b0\uc758 \ud56d\uc751\uace0\uc791\uc6a9\uc774 \uc5c4\ubc00\ud55c \uc758\ubbf8\uc5d0\uc11c \ub2e8\uc810\uc774\ub77c\uace0 \ubcf4\uae30\ub294 \ubb50\ud558\uace0,\u00a0<strong>\ud2b9\uc9d5<\/strong>\uc774\ub77c\uace0 \ud558\ub294 \uac83\uc774 \ub9de\uc744 \uac83\uc774\ub2e4. \uc774\uc81c\ub294 1\ucc28\uc801\uc73c\ub85c \uc758\ub3c4\ud55c \uac83 \uc678\uc758 \uc791\uc6a9, \uc989 \ubd80\uc791\uc6a9\uc774\ub77c\uace0 \ud558\uae30\uc5d4 \uc544\uc2a4\ud53c\ub9b0\uc758 \ud56d\uc751\uace0 \uc791\uc6a9\uc740 \uc544\uc2a4\ud53c\ub9b0\uc758 \uc0c1\uc9d5\ucc98\ub7fc \ub418\uc5b4\ubc84\ub838\uae30 \ub54c\ubb38\uc5d0&#8230;\u00a0<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#fn-10\" data-original-title=\"\"><span id=\"rfn-10\" class=\"target\"><\/span>[10]<\/a>\u00a0\uc0ac\uc2e4 \ubd80\uc791\uc6a9\uc758 &#8216;\ubd80&#8217;\uc790\uac00 \ubd80\uc815\uc801\uc778 \uc758\ubbf8\uac00 \uc544\ub2cc \ud55c\uc790\ub85c &#8216;\ub4a4\ub530\ub97c \ubd80&#8217;\uc790\ub2e4. \uadf8\ub798\uc11c \ubd80\uc791\uc6a9\uc744 \uc601\uc5b4\ub85c\ub294 side effect \ub77c\uace0 \ud55c\ub2e4.<\/p>\n<\/div>\n<p class=\"wiki-heading\"><a id=\"s-6\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#toc\">6.<\/a>\u00a0\uae30\ud0c0<\/p>\n<div class=\"wiki-heading-content\">\n<p><a class=\"wiki-link-internal\" title=\"\uce58\uc544\uad50\uc815\" href=\"https:\/\/namu.wiki\/w\/%EC%B9%98%EC%95%84%EA%B5%90%EC%A0%95\">\uce58\uc544\uad50\uc815<\/a>\uc744 \ud558\ub294 \uc0ac\ub78c\uc740 \uc544\uc2a4\ud53c\ub9b0 \ub300\uc2e0 \ub2e4\ub978 \uc9c4\ud1b5\uc81c(\ud0c0\uc774\ub808\ub180)\ub97c \uba39\ub294 \uac83\uc744 \ucd94\ucc9c\ud55c\ub2e4. \uc544\uc2a4\ud53c\ub9b0\uc758 \uc18c\uc5fc\uc791\uc6a9\uc774 \uce58\uc544\uac00 \uc6c0\uc9c1\uc774\ub294 \uac78 \ubc29\ud574\ud55c\ub2e4\uace0 \ud55c\ub2e4.<\/p>\n<p>\uc720\ub7fd\/\ubd81\ubbf8 \uac00\uc815\uc5d0\uc11c\ub294 \uc5b4\ub51c \uac00\ub098 \uc544\uc2a4\ud53c\ub9b0 \ud55c\ud1b5\uc774 \uc788\uc744 \ub9cc\ud07c \ud754\ud558\ub2e4. \uac1c\uc911\uc5d0\ub294 \ud55c\uad6d\uc5d0 \uc5c6\ub294 \uc885\ub958\ub85c\uc11c Aspirin Plus C\ub77c\ub294 \uac8c \uc788\ub294\ub370, \ubc1c\ud3ec \ube44\ud0c0\ubbfc\ucc98\ub7fc \ubb3c\uc5d0 \ud0c0\uc11c \uba39\ub294 \ud615\ud0dc\uc774\uba70 \ub808\ubaac\ub9db\uc774\ub77c \uadf8\ub7f0\uc9c0\u00a0<a class=\"wiki-link-internal\" title=\"\uc0ac\uc774\ub2e4\" href=\"https:\/\/namu.wiki\/w\/%EC%82%AC%EC%9D%B4%EB%8B%A4\">\uc0ac\uc774\ub2e4<\/a>\uc640 \ube44\uc2b7\ud558\ub2e4 \uce74\ub354\ub77c.<\/p>\n<p>\uc704\uc5d0\uc11c \uc124\uba85\ud55c \ub2e8\uc810\uacfc \ub3d9\uc2dc\uc5d0 \uc131\ub2a5\uc774 \ub354 \uc88b\uc740 \uc9c4\ud1b5\uc81c\uac00 \ub9ce\uc73c\ubbc0\ub85c \uc9c4\ud1b5\uc81c \ubaa9\uc801\uc73c\ub85c\ub294 \uac70\uc758 \ucc98\ubc29\ud558\uc9c0 \uc54a\ub294\ub2e4. \ucd9c\ud608 \ubb38\uc81c\ub3c4 \uadf8\ub807\uac70\ub2c8\uc640, \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774\ub098 \uc774\ubd80\ud504\ub85c\ud39c \ubcf5\ud569\uc57d\uc81c\uac00 \uc544\uc2a4\ud53c\ub9b0\ubcf4\ub2e4 \uc9c4\ud1b5 \ud6a8\uacfc\uac00 \uc6b0\uc6d4\ud558\ub2e4. \ub2e8, \uc18c\uc5fc\ud6a8\uacfc\uc5d0\uc11c\ub294 \uc544\uc2a4\ud53c\ub9b0\uc774 \ub0ab\uc9c0\ub9cc \uc18c\uc5fc\ud6a8\uacfc\uac00 \ud544\uc694\ud558\uba74 \uc544\uc608 \ud56d\ud788\uc2a4\ud0c0\ubbfc\uc81c\uc778 \ub2e4\ub978 \uc18c\uc5fc\uc81c\ub97c \uc4f0\ub294 \uac8c \ub0ab\ub2e4. 500mg \uc77c\ubc18 \uc544\uc2a4\ud53c\ub9b0 20\uc815\uc758 \uc18c\ub9e4\uac00\ub294 2500-3000\uc6d0 \uc815\ub3c4\uc774\ub2e4.<\/p>\n<p>\ud608\uc804 \uc608\ubc29 \ub4f1 \uc2ec\ud608\uad00 \uc9c8\ud658 \uc608\ubc29\uc81c\ub85c \ub110\ub9ac \uc4f0\uc774\ub294 \uc800\uc6a9\ub7c9(100 mg-85mg) \uc544\uc2a4\ud53c\ub9b0\uc758 \uad6d\ub0b4 \uc18c\ub9e4\uac00\ub294 100\uc815\uc740 7\ucc9c\uc6d0, 500\uc815\uc740 2\ub9cc5\ucc9c\uc6d0 \uc815\ub3c4\uc774\ub2e4. \ucc38\uace0\ub85c \ub204\uad6c\ub098 \uba39\uc744 \ud544\uc694\ub294 \uc5c6\uace0, \uc704\ud5d8\ud55c \uc0ac\ub78c\ub9cc \uba39\ub294 \uac83\uc774\ub2e4. \uadf8\ub7ec\ub098 \uc5b4\ub5a4 \uc0ac\ub78c\uc774 \uc704\ud5d8\ud55c\uc9c0\ub294 \ub2e4 \uc801\uc744 \uc218\uac00 \uc5c6\uc73c\ub2c8, \uc774\ud558\uc5d0 \ud558\ub098\ub77c\ub3c4 \uac78\ub9b0\ub2e4\uba74 \uc758\uc0ac\uc640 \uc0c1\ub2f4\ud558\uc5ec \uc544\uc2a4\ud53c\ub9b0 \ubcf5\uc6a9\uc774 \uc2e4\uc775\uc774 \uc788\ub294\uc9c0 \ud655\uc778\ud574\ubcf4\ub77c.<\/p>\n<ul class=\"wiki-list\">\n<li>\ub098\uc774\uac00 60\uc138 \uc774\uc0c1<\/li>\n<li>\uac00\uc871 \uc911\uc5d0 \uc2ec\ud608\uad00\uc9c8\ud658, \uc911\ud48d\uc5d0 \uac78\ub9b0 \uc0ac\ub78c\uc774 1\uba85 \uc774\uc0c1<\/li>\n<li>20\ub144 \uc774\uc0c1\uc758 \ud761\uc5f0\uc790<\/li>\n<li>\uac70\ub3d9\uc774 \ubd88\ud3b8\ud55c \uc0ac\ub78c(\uc218\uc220, \uc7a5\uc560 \ubaa8\ub450 \ud3ec\ud568)<\/li>\n<\/ul>\n<p>\ud608\uc804\uc0dd\uc131\uc5b5\uc81c \ubaa9\uc801\uc73c\ub85c \uc544\uc2a4\ud53c\ub9b0 100mg\ub97c \ubcf5\uc6a9\ud558\ub294 \uc0ac\ub78c\uc740, \uce58\uacfc\uce58\ub8cc\ub098 \uc218\uc220\uc2dc\uc5d0 \ud608\uc561\uc751\uace0\uac00 \uc548\ub418\uae30 \ub54c\ubb38\uc5d0 \ubcf4\ud1b5 7\uc77c \uc804\uc5d0 \ubcf5\uc6a9\uc744 \uc911\uc9c0\ud574\uc57c \ud55c\ub2e4.<\/p>\n<p>\uc544\uc2a4\ud53c\ub9b0\uc744 \ubc14\ub974\ub294 \ub9c8\uc2a4\ud06c \ud329\uc73c\ub85c \ub9cc\ub4e4\uc5b4 \uc0ac\uc6a9\ud558\uba74 \ud53c\ubd80 \ubbf8\uc6a9\uc5d0 \uc88b\ub2e4\ub294 \uc18c\ubb38\uc774 \ub3cc\uace0 \uc788\ub294\ub370 \uc804\ud600 \uacfc\ud559\uc801 \uadfc\uac70\uac00 \uc5c6\ub294 \ub0ad\uc124\uc774\uba70, \uc815\ub9d0\ub85c \uadf8\ub807\uac8c \ud558\ub2e4\uac04\u00a0<strong>\ud53c\ubd80 \uc791\uc0b4\ub09c\ub2e4<\/strong>.\u00a0<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#fn-11\" data-original-title=\"\"><span id=\"rfn-11\" class=\"target\"><\/span>[11]<\/a>\u00a0\ubb3c\ub860 \uc2e4\uc81c\ub85c \uc544\uc2a4\ud53c\ub9b0\uc774 \ub4e4\uc5b4\uac04 \ud654\uc7a5\ud488\uc774 \uc788\uae34 \ud558\uc9c0\ub9cc\u00a0<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#fn-12\" data-original-title=\"\"><span id=\"rfn-12\" class=\"target\"><\/span>[12]<\/a>, \uc81c\ub300\ub85c \ub41c \uc6a9\ubc95\uacfc \uc6a9\ub7c9\uc744 \uc9c0\ud0a4\uc9c0 \uc54a\uace0 \ud53c\ubd80\uc5d0 \uc798\ubabb \ubc1c\ub790\ub2e4\uac00\ub294\u00a0<strong>\ub9cc\uc131<\/strong>\u00a0\ub450\ub4dc\ub7ec\uae30, \ubc1c\uc9c4 \ub4f1\uc758 \ubd80\uc791\uc6a9\uc774 \uc0dd\uae38 \uc218 \uc788\uc73c\ub2c8 \uc9c1\uc811 \uc544\uc2a4\ud53c\ub9b0\uc744 \ud53c\ubd80\uc5d0 \ubc14\ub97c \uc0dd\uac01\uc740 \uc811\ub3c4\ub85d \ud558\uc790. \uc544\uc2a4\ud53c\ub9b0\uc744 \ud53c\ubd80\uc5d0 \uce60\ud558\ub294\uac74\u00a0<a class=\"wiki-link-internal\" title=\"\ubb34\uc880\" href=\"https:\/\/namu.wiki\/w\/%EB%AC%B4%EC%A2%80\">\ubb34\uc880<\/a>\uce58\ub8cc\ud55c\ub2e4\uace0\u00a0<a class=\"wiki-link-internal\" title=\"\ube59\ucd08\uc0b0\" href=\"https:\/\/namu.wiki\/w\/%EB%B9%99%EC%B4%88%EC%82%B0\">\ube59\ucd08\uc0b0<\/a>\uc744 \ubc14\ub974\ub294 \uac83\uc774\ub098 \ub611\uac19\uc740 \ud589\ub3d9\uc774\ub2e4.<\/p>\n<p>\uc544\uc2a4\ud53c\ub9b0 \ud55c \uc54c \uc815\ub3c4\ub97c \uc73c\uae68\uc11c \ud0c4 \ubb3c\uc5d0 \uc0dd\ud654\ub97c \uaf42\uc544\ub450\uba74, \uaf43\uc758 \uc218\uad00\uc5d0 \ubc15\ud14c\ub9ac\uc544\uac00 \uc99d\uc2dd\ud558\ub294 \uac83\uc744 \uc5b5\uc81c\ud55c\ub2e4. \uc0ac\uc2e4 \uc544\uc2a4\ud53c\ub9b0\ubfd0 \uc544\ub2c8\ub77c\u00a0<a class=\"wiki-link-internal\" title=\"\uc0ac\uc774\ub2e4\" href=\"https:\/\/namu.wiki\/w\/%EC%82%AC%EC%9D%B4%EB%8B%A4\">\uc0ac\uc774\ub2e4<\/a>\ub098\u00a0<a class=\"wiki-link-internal\" title=\"\ub77d\uc2a4\" href=\"https:\/\/namu.wiki\/w\/%EB%9D%BD%EC%8A%A4\">\ub77d\uc2a4<\/a>\u00a0\ub4f1\uc758 \ub2e4\ub978 \uc0b0\uc131 \ubb3c\uc9c8\ub4e4\ub3c4 \uac19\uc740 \uc791\uc6a9\uc744 \ud55c\ub2e4. \ud558\uc9c0\ub9cc \ub18d\ub3c4\ub97c \ub9de\ucd94\ub294 \uac8c \uc911\uc694\ud558\uace0 \uadf8\ub807\uc9c0 \uc54a\uc73c\uba74 \uc5ed\ud6a8\uacfc\uac00 \ub0a0 \uc218 \uc788\uae30 \ub54c\ubb38\uc5d0, \uc9d1\uc5d0 \uc0c1\ube44\uc57d\uc73c\ub85c \ud754\ud788 \ub450\ub294 \uc544\uc2a4\ud53c\ub9b0\uc744 \ud55c \uc54c \ud22c\uc785\ud558\ub294 \uac8c \uac04\ud3b8\ud558\ub2e4. \uc544\ub2c8\uba74 \uaf43\uc9d1\uc5d0\uc11c \ud30c\ub294 \uc808\ud654\uc5f0\uc7a5\uc81c\ub97c \uad6c\uc785\ud558\uba74 \ub41c\ub2e4.<\/p>\n<p>\uc720\uc0b0 \uacbd\ud5d8\uc774 \uc788\ub294 \uc5ec\uc131\uc774 \uad00\uacc4 \uc804 \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\uba74 \uc544\ub4e4\uc744 \ucd9c\uc0b0\ud560 \ud655\ub960\uc774 \ub192\uc544\uc9c4\ub2e4\ub294 \uc5f0\uad6c \uacb0\uacfc\uac00 \ub098\uc654\ub2e4. \uc544\uc2a4\ud53c\ub9b0 \uad70\uc758 \ub0a8\uc544 \ucd9c\uc0b0\uc728\uc740 31%\ub85c \uc5fd\uc0b0 \ub300\uc870\uad70\uc758 23%\uc5d0 \ube44\ud574 \ud6e8\uc52c \ub192\uac8c \ub098\ud0c0\ub09c \uac83. \uc2b5\uad00\uc131 \uc720\uc0b0\uc740 \uc790\uad81\uc5d0 \ucc29\uc0c1\ud55c \ud0dc\uc544\ub97c \uc774\ubb3c\uc9c8\ub85c \uac04\uc8fc\ud558\uc5ec \uba74\uc5ed\uccb4\uacc4\uac00 \uacf5\uaca9\uc744 \ud558\ub294\ub370, \ub0a8\uc544\ub294 \uac70\ubd80\ubc18\uc751\uc774 \ud2b9\ud788 \uac70\uc138\uae30 \ub54c\ubb38\uc5d0 \ucd9c\uc0b0 \uac00\ub2a5\uc131\uc774 \ub354 \ub5a8\uc5b4\uc9c0\ub098 \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud55c \uacbd\uc6b0 \uc5fc\uc99d \ud45c\uae30\uac00 \uc904\uc5b4\ub4e4\uc5c8\ub2e4.<a class=\"wiki-link-external\" title=\"http:\/\/news.nate.com\/view\/20160706n12663?mid=n1006\" href=\"http:\/\/news.nate.com\/view\/20160706n12663?mid=n1006\" target=\"_blank\" rel=\"noopener noreferrer\">#<\/a><\/p>\n<p>\uc544\uc2a4\ud53c\ub9b0\uc774 \ucda9\uce58 \uce58\ub8cc\uc5d0 \ud6a8\uacfc\uac00 \uc788\ub2e4\ub294 \uc5f0\uad6c\uacb0\uacfc\uac00 \ub098\uc654\ub2e4. \uc601\uad6d \ubca8\ud30c\uc2a4\ud2b8 \ud038\uc988\ub300\ud559 \uce58\uc758\ub300 \ubcf4\uc874\uce58\uacfc \uc804\ubb38\uc758 \uc774\ud074\ub77c\uc2a4 \uc5d8 \uce74\ub9bc \ubc15\uc0ac\ub294 \uc544\uc2a4\ud53c\ub9b0\uc774 \ucda9\uce58\ub85c \uc190\uc0c1\ub41c \uce58\uc544\uc758 \uc0c1\uc544\uc9c8\uc744 \uc7ac\uc0dd\uc2dc\ud0a4\ub294 \ub2a5\ub825\uc774 \uc788\ub2e4\ub294 \uc5f0\uad6c\uacb0\uacfc\ub97c \ubc1c\ud45c\ud588\ub2e4. \uc544\uc2a4\ud53c\ub9b0\uc740 \uc0c1\uc544\uc9c8 \ud615\uc131\uc744 \ub2f4\ub2f9\ud558\ub294 \uc720\uc804\uc790\uc640 \uce58\uc544 \uc904\uae30\uc138\ud3ec\ub97c \ud65c\uc131\ud654\uc2dc\ucf1c \uc0c1\uc544\uc9c8\uc758 \uc7ac\uc0dd\uc744 \ub3d5\ub294\ub2e4\ub294 \uc0ac\uc2e4\uc774 \uc2dc\ud5d8\uad00 \uc2e4\ud5d8\uc744 \ud1b5\ud574 \ud655\uc778\ub410\ub2e4\uace0 \uc5d8 \uce74\ub9bc \ubc15\uc0ac\ub294 \ubc1d\ud614\ub2e4. \uc2e4\ud5d8\uc6a9 \ud398\ud2b8\ub9ac \uc811\uc2dc\uc5d0\uc11c \uc190\uc0c1\ub41c \uc0c1\uc544\uc9c8\uc758 \uc904\uae30\uc138\ud3ec\ub97c \uc18c\ub7c9\uc758 \uc544\uc2a4\ud53c\ub9b0\uc5d0 \ub178\ucd9c\uc2dc\ud0a4\uc790 \uc0c1\uc544\uc9c8\uc744 \uad6c\uc131\ud558\ub294 \ubbf8\ub124\ub784\uc774 \uc99d\uac00\ud558\uba74\uc11c \uc190\uc0c1\ub41c \ubd80\ubd84\uc774 \uc7ac\uc0dd\ub410\ub2e4\uace0 \uadf8\ub294 \uc124\uba85\ud588\ub2e4. \uad6c\uac15 \ubc15\ud14c\ub9ac\uc544\uac00 \uce58\uc544\uc758 \ub9e8 \uac89 \ubd80\ubd84\uc778 \ubc95\ub791\uc9c8\uc744 \ub6ab\uace0 \uadf8 \uc544\ub798\uc5d0 \uc788\ub294 \uc0c1\uc544\uc9c8\uc744 \uc7a0\uc2dd\ud558\ub294 \uac83\uc774 \ucda9\uce58\ub2e4. \uc0c1\uc544\uc9c8\uc740 \uc790\uc5f0\uc801\uc778 \uc7ac\uc0dd \uae30\ub2a5\uc774 \uc81c\ud55c\uc801\uc774\ub2e4. \uc190\uc0c1 \ubd80\uc704\uac00 \ucee4\uc9c0\uba74\uc11c \uce58\uc218(\u9f52\u9ad3: dental pulp)\uac00 \ub178\ucd9c\ub418\uba74 \uc790\uc5f0\uc801\uc778 \uc218\ub9ac\ub294 \ubd88\uac00\ub2a5\ud558\ub2e4. \ud604\uc7ac\uc758 \ucda9\uce58 \uce58\ub8cc\ub294 \uce58\uc544\uc758 \ub6ab\ub9b0 \uad6c\uba4d\uc744 \ucda9\uc804\uc7ac\ub85c \uba54\uc6b0\ub294 \uac83\uc774\uc9c0\ub9cc \uc601\uad6c\uc801\uc778 \ud574\uacb0\ucc45\uc740 \ubabb\ub418\uba70 \uc2dc\uac04\uc774 \uac00\uba74\uc11c \uc218\uc2dc\ub85c \uac08\uc544 \ub07c\uc6cc\uc57c \ud55c\ub2e4. \uc544\uc2a4\ud53c\ub9b0\uc740 \uc0c1\uc544\uc9c8\uc744 \uc7ac\uc0dd\uc2dc\ud0a4\ub294 \ub9cc\ud07c \uc601\uad6c\uc801\uc778 \ud574\uacb0\ucc45\uc774 \ub420 \uc218 \uc788\ub2e4. \ubb38\uc81c\ub294 \uc544\uc2a4\ud53c\ub9b0\uc744 \uc5b4\ub5a4 \ubc29\uc2dd\uc73c\ub85c \ud22c\uc5ec\ud558\ub290\ub0d0\uc774\ub2e4. \uc544\uc2a4\ud53c\ub9b0\uc744 \ub2e8\uc21c\ud788 \ucda9\uce58\uc5d0 \ub3c4\ud3ec\ud588\ub2e4\uac00\ub294 \uadf8\ub300\ub85c \uc4f8\ub824\ub098\uac08 \uac83\uc774\uace0 \uc190\uc0c1\ub41c \ubd80\uc704\uc5d0 \uc624\ub7ab\ub3d9\uc548 \uc9c0\uc18d\ud574\uc11c \ud22c\uc5ec\ud560 \uc218 \uc788\ub294 \ubc29\ubc95\uc744 \ucc3e\uc544\uc57c \ud55c\ub2e4\uace0 \uc5d8 \uce74\ub9bc \ubc15\uc0ac\ub294 \uc9c0\uc801\ud588\ub2e4. \uadf8\ub7ec\uc790\uba74 \ucda9\uce58 \ubd80\uc704\uc5d0 \uacc4\uc18d\ud574\uc11c \uc544\uc2a4\ud53c\ub9b0\uc744 \ubc29\ucd9c\ud560 \uc218 \uc788\ub294 \uc7a5\uce58\ub97c \uac1c\ubc1c\ud574\uc57c \ud560 \uac83\uc774\ub77c\uace0 \uadf8\ub294 \ub9d0\ud588\ub2e4. \uc774 \uc5f0\uad6c\uacb0\uacfc\ub294 \ud50c\ub9ac\uba38\uc2a4\uc5d0\uc11c \uac1c\ub9c9\ub41c \uc601\uad6d \uad6c\uac15\u00b7\uce58\uacfc \uc5f0\uad6c\ud559\ud68c(British Society for Oral and Dental Research) \ud559\uc220\ud68c\uc758\uc5d0\uc11c \ubc1c\ud45c\ub410\ub2e4.<\/p>\n<p>\ud55c\ub54c\u00a0<a class=\"wiki-link-internal\" title=\"\ud504\ub85c\ub808\uc2ac\ub9c1\" href=\"https:\/\/namu.wiki\/w\/%ED%94%84%EB%A1%9C%EB%A0%88%EC%8A%AC%EB%A7%81\">\ud504\ub85c\ub808\uc2ac\ub9c1<\/a>\uc5d0\uc11c \ube14\ub7ec\ub4dc \uc7a1\uc73c\ub85c \ud53c\ub97c \ub0bc\ub54c \ud56d\uc751\uace0 \uc131\ubd84\uc744 \uc774\uc6a9, \uc544\uc2a4\ud53c\ub9b0\uc744 \uba39\uace0 \ucd9c\ud608\uc744 \ub0c8\uc73c\ub098, \ud604\uc7ac\ub294 \ucea1\uc290\uc744 \uc774\uc6a9, \ub354 \uc548\uc804\ud558\uac8c \ucd9c\ud608 \uc5f0\ucd9c\uc744 \ud558\ub294\uc9c0\ub77c \uba54\uc774\uc800 \ub2e8\uccb4\uc5d0\uc11c\ub294 \uc0ac\uc7a5\ub41c \ubc29\uc2dd\uc774\uae30\ub3c4 \ud558\ub2e4.<\/p>\n<p>2016\ub144 \uc7a5\uae30\ubcf4\uc874\uc548\uc815\uc131 \uc2e4\ud5d8\uc5d0\uc11c \uae30\uc900 \ubbf8\ub2ec\uacfc \ub354\ubd88\uc5b4 \uc0dd\uc0b0 \uacf5\uc7a5\uc758 \ub3c5\uc77c \uc774\uc804 \ub4f1\uc73c\ub85c \uc778\ud574 \ud55c\ub3d9\uc548 \uad6d\ub0b4 \uc544\uc2a4\ud53c\ub9b0 \uacf5\uae09\uc774 \uc774\ub904\uc9c0\uc9c0 \ubabb\ud588\uc9c0\ub9cc, \uc774\uc5d0 \ub300\ud55c \ub300\ucc98\uc640 \ud568\uaed8 2018\ub144 8\uc6d4 10\uc77c\ubd80\ud130 \uad6d\ub0b4 \uacf5\uae09\uc744 \uc7ac\uac1c\ud588\ub2e4\uace0 \ud55c\ub2e4.<\/p>\n<\/div>\n<div class=\"wiki-macro-footnote\"><span class=\"footnote-list\"><span id=\"fn-1\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#rfn-1\">[1]<\/a>\u00a0\ub2e4\ub9cc \uc138\ud3ec\ub9c9\uc758 2\uc911 \uad6c\uc870\uc5d0\uc11c \uc548\ucabd\uc740 \ube44\uadf9\uc131\uc774\ubbc0\ub85c \uadf9\uc131 \ubd80\ubd84\uc744 \ud1b5\uacfc\ud55c \uc544\uc138\ud2b8\uc0b4\ub9ac\uc2e4\uc0b0\uc740 \ubc18\ub4dc\uc2dc \uc218\uc18c\ub97c \ubc1b\uc544\uc11c \ub2e4\uc2dc \uc77c\ubc18\uc801\uc778 \uc0c1\ud0dc\ub85c \ub3cc\uc544\uac00\uc57c \ud55c\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-2\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#rfn-2\">[2]<\/a>\u00a0\ud55c\uad6d\uc758 \uace0\uc0b0\uc9c0\ub300\uc5d0\ub3c4 \ud130\ub9ac\ud480\uc774\ub780 \uc774\ub984\uc758 \ub3d9\uc18d\uc774\uc885 \uc2dd\ubb3c\uc774 \uc788\ub2e4.(<em>F. glaberrima<\/em>)<\/span><span class=\"footnote-list\"><span id=\"fn-3\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#rfn-3\">[3]<\/a>\u00a0\uc544\uc138\ud2b8\uc0b0\uc744 \uc774\uc6a9\ud558\uba74 \uc0dd\uc131\ub418\ub294 \ubb3c\ub85c \uc778\ud574 \uc5ed\ubc18\uc751\uc774 \ucd09\uc9c4\ub418\ubbc0\ub85c \ubb3c\uc774 \uc5c6\ub294 \ubb34\uc218\uc544\uc138\ud2b8\uc0b0\uc744 \uc774\uc6a9\ud55c\ub2e4\ub294 \uc124\uba85\uc774 \ub110\ub9ac \ud37c\uc838 \uc788\ub294\ub370, \uc5ed\ubc18\uc751 \uc5b5\uc81c\ubcf4\ub2e4\ub3c4 \uce74\ubcf4\ub2d0 \ud0c4\uc18c\uc758 electrophilicity\ub97c \uc99d\uac00\uc2dc\ud0a4\uae30 \uc704\ud55c \ubaa9\uc801\uc774 \ud06c\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-4\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#rfn-4\">[4]<\/a>\u00a0\uace0\uc628 \uace0\uc555\uc774 \uc544\ub2c8\ub77c\uba74 \ud398\ub180\uc774 \ub9cc\ub4e4\uc5b4\uc9c4\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-5\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#rfn-5\">[5]<\/a>\u00a0\uc77c\ubcf8\uacf5\ub300\ub97c \uc900\ube44\ud558\ub294 \uc0ac\ub78c\uc774\ub77c\uba74 \uc2dc\ud5d8\uc900\ube44 \uc0bc\uc544 \uc54c\uc544\ub450\uba74 \uc88b\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-6\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#rfn-6\">[6]<\/a>\u00a0\uc9c4\ud1b5\uc81c\ub85c \ubd84\ub958\ud558\uc9c0\ub9cc \uc9c4\ud1b5 \uc791\uc6a9\ubcf4\ub2e4 \ud56d\uc751\uace0\uc791\uc6a9\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd94\uc5b4 \uc0ac\uc6a9\ud558\uace0 \uc788\ub2e4\ub294 \uac83\uc774 \uc544\uc774\ub7ec\ub2c8.<\/span><span class=\"footnote-list\"><span id=\"fn-7\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#rfn-7\">[7]<\/a>\u00a0\ub354 \uac04\ub2e8\ud788 \ub9d0\ud558\uc790\uba74, \ud53c\ub97c \ubb3d\uac8c \ud55c\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-8\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#rfn-8\">[8]<\/a>\u00a0\uc9c4\ud1b5\uc81c 3\ub300\uc7a5\uc778\u00a0<a class=\"wiki-link-internal\" title=\"\uc774\ubd80\ud504\ub85c\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EC%9D%B4%EB%B6%80%ED%94%84%EB%A1%9C%ED%8E%9C\">\uc774\ubd80\ud504\ub85c\ud39c<\/a>,\u00a0<a class=\"wiki-link-internal\" title=\"\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C\">\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c<\/a>\u00a0\ubaa8\ub450 \uace0\uc0b0\ubcd1\uc5d0 \ud6a8\uacfc\uac00 \uc788\uc73c\ub098 \uc81c\uc77c \ub9ce\uc774 \uc4f0\ub294 \uac83\uc740 \uc774\ubd80\ud504\ub85c\ud39c\uc774\ub2e4. \ucd5c\uadfc \uc5f0\uad6c\uacb0\uacfc\uc5d0\ub294 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\ub3c4 \uc774\ubd80\ud504\ub85c\ud39c\uacfc \ud070 \ucc28\uc774\uac00 \uc5c6\ub294 \uac83\uc73c\ub85c \ub098\uc628\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-9\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#rfn-9\">[9]<\/a>\u00a0\uc544\uc2a4\ud53c\ub9b0, \uc544\uc2a4\ud2b8\ub9ad\uc2a4 \uac19\uc740 \ud56d\ud608\uc18c\ud310\uc81c\ub098\u00a0<a class=\"wiki-link-internal\" title=\"\uc640\ud30c\ub9b0\" href=\"https:\/\/namu.wiki\/w\/%EC%99%80%ED%8C%8C%EB%A6%B0\">\uc640\ud30c\ub9b0<\/a>\u00a0\uac19\uc740 \ud56d\uc751\uace0\uc81c\ub294 \ub1cc\uacbd\uc0c9\uc758 \uc608\ubc29\uc774\ub098 \uce58\ub8cc\uc5d0 \uc4f0\uc77c \uc218\ub294 \uc788\uc9c0\ub9cc, \uc774\ub7ec\ud55c \uc57d\uc744 \uc7a5\uae30\uac04 \ubcf5\uc6a9\ud560 \uacbd\uc6b0 \uc624\ud788\ub824\u00a0<a class=\"wiki-link-internal\" title=\"\ub1cc\" href=\"https:\/\/namu.wiki\/w\/%EB%87%8C\">\ub1cc<\/a>\ucd9c\ud608\uc744 \uc720\ubc1c\ud560 \uc218 \uc788\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-10\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#rfn-10\">[10]<\/a>\u00a0\uc544\uc608 \ud56d\uc751\uace0\uc81c\ub85c\uc368\ub3c4 \uc4f0\uc774\uac8c \ub418\uc5b4\ubc84\ub838\uc73c\ub2c8&#8230;<\/span><span class=\"footnote-list\"><span id=\"fn-11\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#rfn-11\">[11]<\/a>\u00a0\uc5fc\uc0b0\ub9cc\ud07c\uc740 \uc544\ub2c8\uc9c0\ub9cc \uc77c\ub2e8\u00a0<strong>\uc0b0<\/strong>\uc774\ubbc0\ub85c \ud53c\ubd80\uac00 \uc0c1\ud558\ub294 \uac74 \ub2f9\uc5f0\ud558\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-12\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0#rfn-12\">[12]<\/a>\u00a0\uc0b4\ub9ac\uc2e4\uc0b0\uc774 \ud53c\ubd80\uc758 \uac01\uc9c8\uc744 \ub179\uc774\ub294 \uac83\uc744 \uc774\uc6a9\ud55c \uac83\uc774\ub2e4.<\/span><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h5>\uc774\ubd80\ud504\ub85c\ud39c<\/h5>\n<p>&nbsp;<\/p>\n<div class=\"wiki-heading-content\">\n<p>\ubbf8\uad6d \uc560\ubcf4\ud2b8\uc0ac(\uad6c \uc601\uad6d \ubd80\uce20, \ub3c5\uc77c Knoll)\uc5d0\uc11c \uac1c\ubc1c\ub418\uc5c8\uc73c\uba70 \ud654\ud559\uba85\uc740 \uc774\uc18c\ubd80\ud2f8\ud504\ub85c\ud310\ud398\ub180\uc0b0(<strong>I<\/strong>so<strong>bu<\/strong>tyl<strong>pro<\/strong>panoic<strong>phen<\/strong>olic acid).<\/p>\n<p>\ub300\ud45c\uc801\uc778 \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\uc131 \ud56d\uc5fc\uc99d<a class=\"wiki-link-internal\" title=\"\uc9c4\ud1b5\uc81c\" href=\"https:\/\/namu.wiki\/w\/%EC%A7%84%ED%86%B5%EC%A0%9C\">\uc9c4\ud1b5\uc81c<\/a>\uc774\uba70, \ud56d\uc5fc\uc99d\uc81c\ubcf4\ub2e8 \uc9c4\ud1b5\uc81c\ub85c \uc720\uba85\ud558\ub2e4. \uc9c4\ud1b5, \ud574\uc5f4, \ud56d\uc5fc\uc99d\uc791\uc6a9\uc744 \ud558\uba70 \ud6a8\uacfc\uac00 \ub05d\ub0b4\uc900\ub2e4. \uc5f4\uc774 \uc62c\ub77c\uc11c \ud798\ub4e4\uba74 \ud55c \ubc88\ucbe4 \uc2dc\ub3c4\ud574\ubcfc \ub9cc\ud55c \uc57d.\u00a0<a class=\"wiki-link-internal\" title=\"\uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0\">\uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0<\/a>(\uc544\uc2a4\ud53c\ub9b0)\uacfc\ub294 \ube44\uad50\uac00 \uc548 \ub418\uace0\u00a0<a class=\"wiki-link-internal\" title=\"\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C\">\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c<\/a>(\ud0c0\uc774\ub808\ub180)\uacfc \uc790\uc6c5\uc744 \uaca8\ub8ec\ub2e4. \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc740 \ud56d\uc5fc\uc99d \uc791\uc6a9\uc774 \uc5c6\ub294 \ud574\uc5f4\uc9c4\ud1b5\uc81c\uc774\uba70 \uc774\ubd80\ud504\ub85c\ud39c\uc740 \uc9c4\ud1b5 \ud574\uc5f4 \ud56d\uc5fc\uc99d \uc791\uc6a9\uc774 \ubaa8\ub450 \uc788\ub2e4. \ud558\uc9c0\ub9cc \ubd80\uc791\uc6a9\uc758 \uc885\ub958\uc640 \uc815\ub3c4\ub294 \uc774\ubd80\ud504\ub85c\ud39c\uc774 \ub354 \uc2ec\ud558\ub2e4. \uadf8\ub7ec\ub098 \uc801\uc815\ub7c9 \uc774\uc0c1 \ubcf5\uc6a9\ud558\uac70\ub098 \uc220\uacfc \ud568\uaed8 \ubcf5\uc6a9\ud560 \uacbd\uc6b0 \ud0c0\uc774\ub808\ub180\uc774 \ud6e8\uc52c \uce58\uba85\uc801\uc778 \uacb0\uacfc(\uc0ac\ub9dd)\ub97c \uc57c\uae30\ud560 \uc218 \uc788\ub2e4. \ub54c\ubb38\uc5d0 \ucd5c\uadfc\uc5d0\ub294 \ub450 \uc57d\uc5d0 \ub300\ud55c \ud3c9\uac00\uac00 \ubc14\ub00c\ub294 \uc911\uc774\ub2e4. \ub458 \ub2e4 \ud6cc\ub96d\ud55c \uc57d\uc774\uc9c0\ub9cc \uc0c1\ud669\uc5d0 \ub530\ub77c\uc11c \uc368\uc57c \ud560 \ub54c\uac00 \ub2e4\ub974\ub2e4. \ub300\ubd80\ubd84\uc758 \ub098\ub77c\uc5d0\uc11c \ucc98\ubc29 \uc5c6\uc774 \uad6c\uc785\ud560 \uc218 \uc788\uc73c\uba70 \ubd81\ubbf8\uc5d0\uc11c\ub294\u00a0<a class=\"wiki-link-internal\" title=\"\uc560\ub4dc\ube4c\" href=\"https:\/\/namu.wiki\/w\/%EC%95%A0%EB%93%9C%EB%B9%8C\">\uc560\ub4dc\ube4c<\/a>(Advill), \uc720\ub7fd\uacfc \ud55c\uad6d\uc5d0\uc11c\ub294\u00a0<del>\ucc29\ud55c \uc5b4\ub9b0\uc774 \ud574\uc5f4\uc5d4<\/del>\u00a0<del>\uc624\ub80c\uc9c0\ub9db \uc2dc\ub7fd<\/del>\u00a0\ubd80\ub8e8\ud39c(Brufen, \uc0bc\uc77c\uc81c\uc57d\uc5d0\uc11c \uc81c\uc870\ud310\ub9e4)\uc774 \uc720\uba85\ud558\ub2e4. \uc601\uad6d\uacfc \ud638\uc8fc\uc5d0\uc11c\ub294 Nurofen \uacc4\uc5f4\uc774 \ub300\uc138\uc778 \ub4ef.<\/p>\n<p>\ud2b9\ud788\u00a0<strong><a class=\"wiki-link-internal\" title=\"\uc0dd\ub9ac\ud1b5\" href=\"https:\/\/namu.wiki\/w\/%EC%83%9D%EB%A6%AC%ED%86%B5\">\uc0dd\ub9ac\ud1b5<\/a><\/strong>\uc5d0\ub294 \uc774\ubd80\ud504\ub85c\ud39c\uc744 \uc81c\uc678\ud55c \ub098\uba38\uc9c0 \uc9c4\ud1b5\uc81c\ub294 \uc544\uc608 \uc548 \ub4e3\ub294 \uc0ac\ub78c\ub4e4\ub3c4 \ub9ce\ub2e4. \ub54c\ubb38\uc5d0 \uc0dd\ub9ac\ud1b5\uc774 \uc2ec\ud55c \uc0ac\ub78c\ub4e4\uc740\u00a0<a class=\"wiki-link-internal\" title=\"\ub371\uc2dc\ubd80\ud504\ub85c\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EB%8D%B1%EC%8B%9C%EB%B6%80%ED%94%84%EB%A1%9C%ED%8E%9C\">\ub371\uc2dc\ubd80\ud504\ub85c\ud39c<\/a>\u00a0\uc815\uc81c\uc778 \uc774\uc9c0\uc5d46 &#8220;\ud504\ub85c&#8221;\ub97c \ud56d\uc0c1 \uac16\uace0 \ub2e4\ub2c8\uae30\ub3c4 \ud55c\ub2e4.<\/p>\n<p><a class=\"wiki-link-internal\" title=\"\ud3b8\ub3c4\uc120\uc5fc\" href=\"https:\/\/namu.wiki\/w\/%ED%8E%B8%EB%8F%84%EC%84%A0%EC%97%BC\">\ud3b8\ub3c4\uc120\uc5fc<\/a>\uc73c\ub85c \ubaa9\uc774 \ub108\ubb34 \uc544\ud30c\uc11c \uace0\uc0dd \uc911\uc774\ub77c\uba74\u00a0<a class=\"wiki-link-internal\" title=\"\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C\">\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c<\/a>\u00a0\ubcf4\ub2e4 \uc774\ubd80\ud504\ub85c\ud39c\uc774 \uc798 \ub4e3\ub294 \ud3b8\uc774\ub2e4. \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc740 \uc6d0\ub798 \uc5fc\uc99d\uc5d0\ub294 \uac70\uc758 \uc791\uc6a9\uc774 \uc5c6\uace0 \ud574\uc5f4, \uc9c4\ud1b5 \uc791\uc6a9\ub9cc \ud558\uae30 \ub54c\ubb38\uc5d0 \ud3b8\ub3c4\uc120\uc5fc\uc5d0\ub294 \uc5fc\uc99d \uc5b5\uc81c\ub97c \uc704\ud574 \uc774\ubd80\ud504\ub85c\ud39c\uc744 \uc4f0\ub294 \uac83\uc774\ub2e4.<\/p>\n<p>\ud55c\uad6d\uc5d0\uc11c\ub294 \ud754\uce58 \uc54a\uc9c0\ub9cc \ubbf8\uad6d \ub4f1\uc9c0\uc5d0\uc11c\ub294 \uc219\ucde8\ub85c \uc778\ud55c \ub450\ud1b5\uc5d0 \uc774\ubd80\ud504\ub85c\ud39c\uc744 \uba39\ub294 \uacbd\uc6b0\uac00 \ub9ce\ub2e4. \uc544\uce68\uc5d0 \uc219\ucde8\ub85c \uc774\ud574 \ub450\ud1b5\uc774 \ub108\ubb34 \uc2ec\ud558\uba74 \uc774\ubd80\ud504\ub85c\ud39c\uc744 \uc801\ub2f9\ub7c9 \uba39\uace0 1\uc2dc\uac04 \uc815\ub3c4 \uc788\uc73c\uba74 \ub450\ud1b5\uc740 \uc0ac\ub77c\uc9c4\ub2e4\uace0 \ud558\ub294\ub370 \ud6a8\uacfc\ub294 \uc5c6\uace0 \ubab8\ub9cc \uc0c1\ud558\ub294 \uc544\uc2a4\ud53c\ub9b0\uc774\ub098 \ud0c0\uc774\ub808\ub180\ubcf4\ub2e4\ub294 \ub098\uc740 \uc120\ud0dd\uc774\ub77c\uace0 \ud55c\ub2e4. \uac8c\ub2e4\uac00 \ud0c0\uc774\ub808\ub180(\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c)\uc774 \uc220\uacfc \ud568\uaed8 \ubcf5\uc6a9\ud558\uba74 \uce58\uba85\uc801\uc778 \uac04\uc190\uc0c1\uc744 \uc57c\uae30\ud558\uc5ec \ud63c\uc218 \uc0c1\ud0dc \ub610\ub294 \uc0ac\ub9dd\uc5d0 \uc774\ub97c \uc218 \uc788\uace0 \uc2e4\uc81c\ub85c \uadf8\ub7f0 \uc0ac\ub840\uac00 \uc801\uc9c0 \uc54a\uac8c \ubc1c\uc0dd\ud558\uc5ec \ubb38\uc81c\uac00 \ub418\uc5c8\uae30 \ub54c\ubb38\uc5d0 \uc74c\uc8fc \ud6c4\uc5d0\ub294 \uc808\ub300 \ud0c0\uc774\ub808\ub180\uc744 \ubcf5\uc6a9\ud558\uc9c0 \uc54a\ub294 \uac83\uc774 \uc0c1\uc2dd\uc73c\ub85c \ud1b5\ud558\uace0 \uc788\ub2e4. \ubb3c\ub860 \ud0c0\uc774\ub808\ub180\uacfc \ub9c8\ucc2c\uac00\uc9c0\ub85c \uac04\uc190\uc0c1\uc758 \uac00\ub2a5\uc131\uc774 \uc788\uc73c\ub2c8 \ub450\ud1b5\uc774 \ub108\ubb34 \uc2ec\ud558\uac70\ub098 \uaf2d \ud544\uc694\ud55c \uacbd\uc6b0\uc5d0\ub9cc \uc12d\ucde8\ud558\ub77c\ub294 \uac83\uc774 \uc804\ubb38\uac00\ub4e4\uc758 \uc785\uc7a5\uc774\ub2e4.<\/p>\n<p>\ub2e8\uc810\uc73c\ub85c\ub294 \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\uc131 \ud56d\uc5fc\uc99d\uc81c(NSAID)\uc758 \uace0\uc9c8\uc801\uc778 \ubd80\uc791\uc6a9\uc744 \uadf8\ub300\ub85c \uc9c0\ub2c8\uace0 \uc788\uae30 \ub54c\ubb38\uc5d0 \ucc9c\uc2dd\uc774\ub098 \uace0\ud608\uc555\uc774 \uc788\ub294 \uc0ac\ub78c\uc774 \ubcf5\uc6a9\ud560 \uacbd\uc6b0 \uc704\ud5d8\ud560 \uc218 \uc788\ub2e4. \uc790\uc138\ud55c \ubd80\uc791\uc6a9\uacfc \uadf8 \ubc1c\uc0dd \uc774\uc720\ub294\u00a0<a class=\"wiki-link-internal\" title=\"NSAID\" href=\"https:\/\/namu.wiki\/w\/NSAID\">NSAID<\/a>\u00a0\ud56d\ubaa9\uc744 \ucc38\uace0.<\/p>\n<p>\ubcf5\uc6a9\ud6c4 \uc57d 1\uc2dc\uac04\uc774 \uc9c0\ub0ac\uc744\ub54c \ubab8\uc5d0 \ub450\ub4dc\ub7ec\uae30\uac00 \ub09c\ub2e4\uba74 \uc774\ubd80\ud504\ub85c\ud39c \uc54c\ub808\ub974\uae30\uac00 \uc788\ub294 \uac83\uc774\ub2c8, \uc18d\ud788 \ubcd1\uc6d0\uc744 \uac08 \uac83.<\/p>\n<\/div>\n<p class=\"wiki-heading\"><a id=\"s-2\" href=\"https:\/\/namu.wiki\/w\/%EC%9D%B4%EB%B6%80%ED%94%84%EB%A1%9C%ED%8E%9C#toc\">2.<\/a>\u00a0\uc774\uc131\uc9c8\uccb4<\/p>\n<div class=\"wiki-heading-content\">\n<p>\uc774\ubd80\ud504\ub85c\ud39c\uc740 \ud6a8\ub2a5\uc774 \uc5c6\ub294 \uac70\uc6b8\uc0c1 \uc774\uc131\uc9c8\uccb4(isomer)\uac00 \uc874\uc7ac\ud55c\ub2e4. (R)-\uc774\ubd80\ud504\ub85c\ud39c\uc73c\ub85c \ud6a8\ub2a5\uc774 \uc788\ub294 \uac83\uc774\uace0, (S)-\uc774\ubd80\ud504\ub85c\ud39c\uc73c\ub85c \ud6a8\ub2a5\uc774 \uc5c6\ub294 \uac83\uc774\ub2e4. \ub2e4\ub9cc \ud6a8\ub2a5\uc774 \uc5c6\ub294 (S)-\uc774\ubd80\ud504\ub85c\ud39c\ub3c4 \uccb4\ub0b4\uc5d0 \ub4e4\uc5b4\uc624\uba74 (R)-\uc774\ubd80\ud504\ub85c\ud39c\uc73c\ub85c \uc804\ud658\ub418\ubbc0\ub85c \ud63c\ud569\ubb3c \uadf8\ub300\ub85c \uc4f0\ub294 \uacbd\uc6b0\ub3c4 \ub9ce\uc73c\ub098, \uc774 \uacfc\uc815\uc5d0\uc11c \uc704\uacbd\ub828 \ub4f1 \uc704\uc7a5\uc5d0\u00a0<a class=\"wiki-link-internal\" title=\"\ubd80\uc791\uc6a9\" href=\"https:\/\/namu.wiki\/w\/%EB%B6%80%EC%9E%91%EC%9A%A9\">\ubd80\uc791\uc6a9<\/a>\uc774 \ub098\ud0c0\ub098\uae30\ub3c4 \ud55c\ub2e4. \ub530\ub77c\uc11c \ud6a8\ub2a5\uc774 \uc788\ub294 (R)-\uc774\ubd80\ud504\ub85c\ud39c\ub9cc \ubf51\uc544\ub0b8 \uac83\uc774 \ubc14\ub85c\u00a0<strong><a class=\"wiki-link-internal\" title=\"\ub371\uc2dc\ubd80\ud504\ub85c\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EB%8D%B1%EC%8B%9C%EB%B6%80%ED%94%84%EB%A1%9C%ED%8E%9C\">\ub371\uc2dc\ubd80\ud504\ub85c\ud39c<\/a><\/strong>(dexibuprofen)\uc774\ub2e4.<\/p>\n<p>\uc624\uc2a4\ud2b8\ub9ac\uc544 Gebro\uc0ac\uc5d0\uc11c \uac1c\ubc1c\ub41c \ub371\uc2dc\ubd80\ud504\ub85c\ud39c\uc740 \uc2e0\uc7a5 \ub3c5\uc131\uc774\ub098 \uc704 \uc790\uadf9\uc774 \uc801\uace0 \uc808\ubc18\uc758 \uc6a9\ub7c9\uc73c\ub85c\ub3c4 \ub611\uac19\uc740 \ud6a8\uacfc\ub97c \ub0bc \uc218 \uc788\uc73c\uba70(\uc774\ub860\uc0c1\uc73c\ub85c \uadf8\ub807\uc9c0\ub9cc \uc784\uc0c1\uc5d0\uc11c\ub294 \ud6a8\uacfc\uac00 \uc808\ubc18 \uc6a9\ub7c9\ubcf4\ub2e4 \uc57d\ud558\ub2e4\ub294 \uac8c \uc77c\ubc18\uc801\uc778 \uacac\ud574\ub2e4. \uc784\uc0c1\uc2e4\ud5d8\uc5d0\uc11c\ub294 \uc774\ubd80\ud504\ub85c\ud39c 10\uacfc \ub371\uc2dc\ubd80\ud504\ub85c\ud39c 7 \uc815\ub3c4\uac00 \ube44\uc2b7\ud55c \uac15\ub3c4\uc758 \uc791\uc6a9\uc744 \ud558\ub294 \uac83\uc73c\ub85c \ub098\uc654\ub2e4.) \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc758 \ud56d\uc5fc\uc99d \uc791\uc6a9\uc774 \ubbf8\ubbf8\ud55c \ub370\uc5d0 \ube44\ud574 \ud56d\uc5fc\uc99d \ud6a8\uacfc \ub610\ud55c \uc788\uae30 \ub54c\ubb38\uc5d0 \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\uc131 \ud56d\uc5fc\uc99d\uc81c(NSAID)\ub85c \ubd84\ub958\ub418\uba70 \uac10\uae30\ub098 \ubab8\uc0b4 \ub4f1\uc758 \uc99d\uc0c1\uc5d0 \ud0c0\uc774\ub808\ub180\ubcf4\ub2e4 \ud6a8\uacfc\uc801\uc774\ub2e4. \ud63c\ud569\ubb3c\uc774\ub4e0 \uc21c\uc218 \uc774\uc131\uc9c8\uccb4\ub4e0 \ubd80\uc791\uc6a9 \uc5ec\ubd80\ub294 \uc0ac\ub78c\ub9c8\ub2e4 \uac1c\uc778\ucc28\uac00 \uc788\uae30 \ub9c8\ub828\uc774\ubbc0\ub85c \ubcf5\uc6a9\ud574\uc57c \ud560 \uc0c1\ud669\uc77c \uacbd\uc6b0 \ud55c \ubc88\uc529 \uc0ac\uc6a9\ud574\ubcf4\uace0 \ubab8\uc5d0 \ub9de\ub294 \uac83\uc744 \uace0\ub974\uba74 \ub41c\ub2e4.<\/p>\n<\/div>\n<p class=\"wiki-heading\"><a id=\"s-3\" href=\"https:\/\/namu.wiki\/w\/%EC%9D%B4%EB%B6%80%ED%94%84%EB%A1%9C%ED%8E%9C#toc\">3.<\/a>\u00a0\uc5ec\ub2f4<\/p>\n<div class=\"wiki-heading-content\">\n<p>\ud55c\uad6d\uc5d0\uc11c\ub294 \uc885\uadfc\ub2f9\uc758 \ud130\ub17c \uc5f0\uc9c8\ucea1\uc290, \ud39c\uc798W, \ub300\uc6c5\uc81c\uc57d\uc758 \uc774\uc9c0\uc5d46<strong>\uc560\ub2c8<\/strong>\u00a0\uc5f0\uc9c8\ucea1\uc290, \uc2e0\ud48d\uc81c\uc57d\uc758 \ub370\ucf54\ud39c\uc815, \uc77c\ub3d9\uc81c\uc57d\uc758 \ucf00\ub864\uc815, \uace0\ub824\uc81c\uc57d\uc758 \uc138\ub77d\ud2f8 \ub4f1\uc73c\ub85c \ud310\ub9e4\ub418\uace0 \uc788\ub2e4. \uadf8 \uc678\uc5d0\ub3c4 \ub9ce\uc740 \ud68c\uc0ac\ub4e4\uc774 \ube44\uc2b7\ud55c \uc81c\ud488\uc744 \ub0b4\ub193\uace0 \uc788\uace0 \ud6a8\ub2a5\uc740 \uac70\uc758 \uac19\uc740\ub370 \uc561\uccb4 \uc5f0\uc9c8\ucea1\uc290 \ud615\ud0dc\ub294 \ud761\uc218\uac00 \ube68\ub77c \ud6a8\uacfc\uac00 \ube60\ub974\ub2e4\ub294 \uac83\uc774 \ub9c8\ucf00\ud305\ud3ec\uc778\ud2b8.<\/p>\n<p>\uc57d\uad6d\uc5d0\uc11c \uad6c\uc785\ud560 \ub54c \uc8fc\uc758\ud574\uc57c \ud560 \uc810\uc774 \ud558\ub098 \uc788\ub294\ub370 \uc2dc\ud310\ub418\ub294 \uc774\ubd80\ud504\ub85c\ud39c\uc740 200mg\uacfc 400mg \ub450 \uc885\ub958\uac00 \uc788\uace0 \ub300\ubd80\ubd84\uc758 \uc57d\uad6d\uc5d0\uc11c \uac00\uaca9\uc774 \ub611\uac19\ub2e4\ub294 \uac83\uc774\ub2e4. \ub2f9\uc5f0\ud55c \uc598\uae30\uc9c0\ub9cc 400mg \ud55c \uc54c\ub9cc \uba39\uc73c\uba74 \ub418\ub294 \uac78 200mg\uc740 \ub450 \uc54c\uc744 \uba39\uc5b4\uc57c \ud55c\ub2e4. \uc5b4\ub9b0\uc774 \uc6a9\uc73c\ub85c \uad6c\uc785\ud558\ub294 \uac8c \uc544\ub2c8\ub77c\uba74 400mg\uc778 \uac78 \ubc18\ub4dc\uc2dc \ud655\uc778\ud558\uace0 \uad6c\uc785\ud558\ub294 \uac8c \uc88b\ub2e4. \uc57d\uad6d\uc5d0 \ub530\ub77c 400mg\uc744 \uc544\uc608 \uad6c\ube44 \uc548 \ud558\ub294 \uacf3\ub3c4 \uc788\ub2e4. \uc6ec\ub9cc\ud558\uba74 \ubc1c\ud488\uc744 \uc870\uae08 \ud314\ub354\ub77c\ub3c4 \ub2e4\ub978 \uc57d\uad6d\uc5d0\uc11c \uad6c\uc785\ud558\uc790.<\/p>\n<p>2014\ub144 12\uc6d4, \uc774\ubd80\ud504\ub85c\ud39c\uc73c\ub85c\u00a0<a class=\"wiki-link-internal\" title=\"\ub3d9\ubb3c\uc2e4\ud5d8\" href=\"https:\/\/namu.wiki\/w\/%EB%8F%99%EB%AC%BC%EC%8B%A4%ED%97%98\">\ub3d9\ubb3c\uc2e4\ud5d8<\/a>\uc744 \ud55c \uacb0\uacfc\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/www.yonhapnews.co.kr\/bulletin\/2014\/12\/22\/0200000000AKR20141222054700009.HTML?input=1195m\uc57d\" href=\"http:\/\/www.yonhapnews.co.kr\/bulletin\/2014\/12\/22\/0200000000AKR20141222054700009.HTML?input=1195m%EC%95%BD\" target=\"_blank\" rel=\"noopener noreferrer\">15% \uc218\uba85\uc774 \uae38\uc5b4\uc9c0\ub294 \uacb0\uacfc\ub97c \ubcf4\uc600\ub2e4\uace0 \ud55c\ub2e4.<\/a>\u00a0\uc0ac\ub78c\uc73c\ub85c \uce58\uba74 12\ub144\uc778\ub370, \ubb3c\ub860\u00a0<a class=\"wiki-link-internal\" title=\"\ucd08\ud30c\ub9ac\" href=\"https:\/\/namu.wiki\/w\/%EC%B4%88%ED%8C%8C%EB%A6%AC\">\ucd08\ud30c\ub9ac<\/a>\u00a0\uac19\uc740 \uc791\uc740 \ub3d9\ubb3c\uc5d0\uac8c \uc2e4\ud5d8\ud55c \uac83\uc774\uace0 \uc0ac\ub78c\uc5d0\uac8c\ub294 \uc5b4\ub5bb\uac8c \uc791\uc6a9\ud560\uc9c0 \uc54c \uc218 \uc5c6\uc73c\ub2c8 \uc124\ub808\ubc1c\uc740 \uae08\ubb3c. \uc815\ud655\ud55c \uc774\uc720\ub294 \uc544\uc9c1 \ubc1d\ud600\uc9c0\uc9c0 \uc54a\uc740 \ub4ef\ud558\ub2e4.<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h5>\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c(\ud0c0\uc774\ub808\ub180)<\/h5>\n<p><a class=\"wiki-link-internal\" style=\"background-color: #ffffff; font-size: 0.875rem;\" title=\"\uc774\ubd80\ud504\ub85c\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EC%9D%B4%EB%B6%80%ED%94%84%EB%A1%9C%ED%8E%9C\">\uc774\ubd80\ud504\ub85c\ud39c<\/a><a class=\"wiki-fn-content\" style=\"background-color: #ffffff; font-size: 0.875rem;\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-1\" data-original-title=\"\"><span id=\"rfn-1\" class=\"target\"><\/span>[1]<\/a><span style=\"font-size: 0.875rem;\">\uacfc \ub354\ubd88\uc5b4 \ub300\ud45c\uc801\uc778 \ud574\uc5f4<\/span><a class=\"wiki-link-internal\" style=\"background-color: #ffffff; font-size: 0.875rem;\" title=\"\uc9c4\ud1b5\uc81c\" href=\"https:\/\/namu.wiki\/w\/%EC%A7%84%ED%86%B5%EC%A0%9C\">\uc9c4\ud1b5\uc81c<\/a><span style=\"font-size: 0.875rem;\">\u00a0\uc131\ubd84\uc774\ub2e4. \ubbf8\uad6d\u00a0<\/span><a class=\"wiki-link-internal\" style=\"background-color: #ffffff; font-size: 0.875rem;\" title=\"\uc874\uc2a8\uc564\ub4dc\uc874\uc2a8\" href=\"https:\/\/namu.wiki\/w\/%EC%A1%B4%EC%8A%A8%EC%95%A4%EB%93%9C%EC%A1%B4%EC%8A%A8\">\uc874\uc2a8\uc564\ub4dc\uc874\uc2a8<\/a><span style=\"font-size: 0.875rem;\">\uc0ac\uc758\u00a0<\/span><strong style=\"font-size: 0.875rem;\">&#8216;\ud0c0\uc774\ub808\ub180<\/strong><span style=\"font-size: 0.875rem;\">&#8216;<\/span><a class=\"wiki-fn-content\" style=\"background-color: #ffffff; font-size: 0.875rem;\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-2\" data-original-title=\"\"><span id=\"rfn-2\" class=\"target\"><\/span>[2]<\/a><span style=\"font-size: 0.875rem;\">\uc774 \ubc14\ub85c \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c \ub2e8\uc77c \uc131\ubd84\uc758 \uc9c4\ud1b5\uc81c\ub2e4. \uadf8 \ubc16\uc5d0 \ud0c0\uc774\ub808\ub180\uc774 \ud55c\uad6d\uc5d0 \uc9c4\ucd9c<\/span><a class=\"wiki-fn-content\" style=\"background-color: #ffffff; font-size: 0.875rem;\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-3\" data-original-title=\"\"><span id=\"rfn-3\" class=\"target\"><\/span>[3]<\/a><span style=\"font-size: 0.875rem;\">\ud558\uae30 \uc804\uc5d0 \uad6d\ub0b4 \uc9c4\ud1b5\uc81c \uc2dc\uc7a5 1~2\uc704\ub97c \ub2e4\ud25c\ub358 \uac8c\ubcf4\ub9b0\uacfc \ud39c\uc798\ub3c4 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc744 \uc8fc\uc131\ubd84\uc73c\ub85c \ud55c \uc57d\uc774\ub2e4. \uc601\uad6d, \ub3c5\uc77c \ub4f1 \uad6d\uac00\uc5d0\uc120 Paracetamol(\ud328\ub7ec\uc2dc\ud130\ubab0)\uc774 \uc720\uba85\ud558\ub2e4.<\/span><a class=\"wiki-fn-content\" style=\"background-color: #ffffff; font-size: 0.875rem;\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-4\" data-original-title=\"\"><span id=\"rfn-4\" class=\"target\"><\/span>[4]<\/a><\/p>\n<div class=\"wiki-heading-content\">\n<p>\uc81c\ubc95\ub3c4 \uac04\ub2e8\ud55c \ub370\ub2e4\uac00 \ud2b9\ud5c8 \ub530\uc704 \ud638\ub791\uc774 \ub2f4\ubc30 \ud53c\ub358 \uc2dc\uc808\uc5d0 \ub9cc\ub8cc\ub41c\uc9c0\ub77c \uc5b4\uc9c0\uac04\ud55c \uc81c\uc57d\ud68c\uc0ac\ub294 \ub9cc\ub4e0\ub2e4\uace0 \ubcf4\uba74 \ub41c\ub2e4. \ub54c\ubb38\uc5d0\u00a0<a class=\"wiki-link-internal\" title=\"\uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0\">\uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0<\/a>\uacfc \ub354\ubd88\uc5b4 \ud559\uad50 \uc2e4\ud5d8\uc2e4\uc5d0\uc11c \ud55c \ubc88\uc529\uc740 \uaf2d \ub9cc\ub4e4\uace0 \ub118\uc5b4\uac00\ub294 \uc758\uc57d\ud488\uc774\ub2e4. \uc5ed\uc0ac\uc131 \ub54c\ubb38\uc778\uc9c0 \ub300\ubd80\ubd84\uc758 \uad50\uc721 \uacfc\uc815\uc5d0\uc11c\ub294 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc744 \ub300\uc2e0\ud558\uc5ec \uc544\uc138\ud2b8\uc544\ub2d0\ub9ac\ub4dc\ub97c \ud569\uc131\ud55c\ub2e4.<\/p>\n<p>\uc801\uc815\ub7c9\ub9cc\uc744 \uc0ac\uc6a9\ud558\uace0 \uc54c\ucf54\uc62c\uacfc \ud63c\uc6a9\ud558\uc9c0 \uc54a\ub294 \ud55c \ud604\uc874\ud558\ub294 \uc9c4\ud1b5\uc81c \uc911 \ubd80\uc791\uc6a9\uc774 \uac70\uc758 \uc5c6\uc5b4 \ub204\uad6c\ub77c\ub3c4 \uc548\uc804\ud558\uac8c \uc0ac\uc6a9\ud560 \uc218 \uc788\ub294 \uc544\ub2d0\ub9b0\uacc4 \ud654\ud569\ubb3c. \uad6d\ub0b4\uc5d0\uc11c\ub294 \uc77c\ubc18\uc758\uc57d\ud488\uc73c\ub85c \ubd84\ub958\ub418\uc5b4 \uc758\uc0ac\uc758 \ucc98\ubc29 \uc5c6\uc774\ub3c4 \uad6c\uc785\ud560 \uc218 \uc788\uc744 \ubfd0\ub9cc \uc544\ub2c8\ub77c \ud3b8\uc758\uc810\uc5d0\uc11c\ub3c4 \uad6c\ub9e4\ud560 \uc218 \uc788\ub294 \uba87 \uc548 \ub418\ub294 \uc57d \uc911 \ud558\ub098\ub2e4. \ubcf5\uc6a9\ub7c9\uc744 \uc900\uc218\ud558\uace0 \uc220\uacfc \ud568\uaed8 \ubcf5\uc6a9\ud558\uc9c0 \uc54a\ub294\ub2e4\uba74\u00a0<a class=\"wiki-link-internal\" title=\"\uc774\ubd80\ud504\ub85c\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EC%9D%B4%EB%B6%80%ED%94%84%EB%A1%9C%ED%8E%9C\">\uc774\ubd80\ud504\ub85c\ud39c<\/a>\ubcf4\ub2e4 \ubd80\uc791\uc6a9\uc774 \uc801\uc740 \uc57d\uc774\ub77c \ud3c9\uac00\ub41c\ub2e4. \ud558\uc9c0\ub9cc \uacfc\ub2e4 \ubcf5\uc6a9\ud558\uac70\ub098 \uc220\uacfc \ud568\uaed8 \ubcf5\uc6a9\ud560 \uacbd\uc6b0 \ud63c\uc218 \uc0c1\ud0dc \ub0b4\uc9c0\ub294 \uc0ac\ub9dd\uc5d0 \uc774\ub97c \uc815\ub3c4\ub85c \uce58\uba85\uc801\uc778 \uacb0\uacfc\ub97c \ucd08\ub798\ud558\uae30\ub3c4 \ud55c\ub2e4.\u00a0<a class=\"wiki-link-internal\" title=\"\uc774\ubd80\ud504\ub85c\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EC%9D%B4%EB%B6%80%ED%94%84%EB%A1%9C%ED%8E%9C\">\uc774\ubd80\ud504\ub85c\ud39c<\/a>\uacfc \ube44\uad50\ud558\uc790\uba74 \uc774\ubd80\ud504\ub85c\ud39c\uc740 \uc5fc\uc99d\uc744 \uc904\uc5ec\uc8fc\ub294 \uc18c\uc5fc\ud6a8\uacfc\uac00 \uc788\ub294 \uc18c\uc5fc\uc9c4\ud1b5\uc81c, \uc544\uc138\ud2b8 \uc544\ubbf8\ub178\ud39c\uc740 \ud574\uc5f4 \ud6a8\uacfc\uac00 \uc788\ub294 \ud574\uc5f4\uc9c4\ud1b5\uc81c. \ubd80\uc791\uc6a9\uc740 \uc774\ubd80\ud504\ub85c\ud39c\uc740 \uc704\uc7a5 \uc7a5\uc560, \uc544\uc138\ud2b8 \uc544\ubbf8\ub178\ud39c\uc740 \uac04\ub3c5\uc131\uc774 \uc788\ub2e4.<\/p>\n<p>\ud0c0\uc774\ub808\ub180(\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c)\uc740 \ud604\uc874\ud558\ub294 \uc57d\ubb3c \uc911 \uac04\ub3c5\uc131\uc774 \uac00\uc7a5 \ud070 \uc57d\ubb3c \uc911 \ud558\ub098\ub85c \ucd5c\ub300\ubcf5\uc6a9\ub7c9 \uc774\uc0c1\uc744 \ubcf5\uc6a9\ud560 \uacbd\uc6b0 \uae09\uc131 \uac04\ubd80\uc804(\uc804\uaca9\uc131\u00a0<a class=\"wiki-link-internal\" title=\"\uac04\uc5fc\" href=\"https:\/\/namu.wiki\/w\/%EA%B0%84%EC%97%BC\">\uac04\uc5fc<\/a>, Acute Liver Failure)\uacfc \uac19\uc740 \uc2ec\uac01\ud55c \uac04\uc190\uc0c1\uc744 \ucd08\ub798\ud560 \uc218 \uc788\ub2e4. \ud2b9\ud788 \uc220\uc744 \ub9c8\uc2e0 \uc0c1\ud0dc\uc5d0\uc11c \ud0c0\uc774\ub808\ub180\uc744 \ubcf5\uc6a9\ud558\uac70\ub098 \ud3c9\uc18c \uc220\uc744 \uc790\uc8fc \ub9c8\uc2dc\ub294 \uc0ac\ub78c\uc774 \ud0c0\uc774\ub808\ub180\uc744 \ubcf5\uc6a9\ud560 \uacbd\uc6b0 \uac04\uc5d0 \uce58\uba85\uc801\uc778 \uc190\uc0c1\uc744 \uc57c\uae30\ud558\uc5ec \uc0ac\ub9dd\uc5d0 \uc774\ub97c \uc218 \uc788\ub2e4. \ubbf8\uad6d\uc5d0\uc11c\ub294 \u200b\ud0c0\uc774\ub808\ub180 \uacfc\ub2e4\ubcf5\uc6a9\uc73c\ub85c \uc5f0\uac04 5\ub9cc 6\ucc9c \uac74 \uc774\uc0c1\uc758 \uc751\uae09\uc2e4\ud589, 2\ub9cc 6\ucc9c\uc5ec \uba85 \uc774\uc0c1\uc758 \uc785\uc6d0, \uc57d 458\uc5ec \uba85\uc758 \uc0ac\ub9dd \uc0ac\uac74\uc774 \ubc1c\uc0dd\ud558\uc5ec \ud0c0\uc774\ub808\ub180\uc758 \uc624\ub0a8\uc6a9\uc758 \uc704\ud5d8\uc131\uc774 \ud06c\uac8c \ubd80\uac01\ub418\uace0 \uc788\ub2e4. \ud0c0\uc774\ub808\ub180\uc774 \uc544\ub2c8\ub354\ub77c\ub3c4 \uac10\uae30\uc57d, \uadfc\uc721\ud1b5\uc57d, \uc0dd\ub9ac\ud1b5\uc57d, \ubcf5\ud1b5\uc57d \uc57d\uc5d0 \ud3ec\ud568\ub418\uc5b4 \uc788\ub294 \uacbd\uc6b0\uac00 \ub9ce\uc544 \ubcf5\uc6a9 \uc2dc \uc8fc\uc758\ub97c \uae30\uc6b8\uc77c \ud544\uc694\uac00 \uc788\ub2e4. \ub54c\ubb38\uc5d0 \ucd5c\uadfc \ubbf8 FDA\ub294 \uc885\ud569\uc9c4\ud1b5\uc81c \ub4f1\uc5d0 \uc0ac\uc6a9\ub418\ub294 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c \uc131\ubd84\uc744 \uaddc\uc81c\ud558\uace0 \uc788\ub2e4. \uc774 \ub54c\ubb38\uc5d0 \ucd5c\uadfc \ud574\uc678\uc5d0\uc11c\ub294 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c \uacc4\uc5f4\ubcf4\ub2e4 \uc774\ubd80\ud504\ub85c\ud39c \uacc4\uc5f4 \uc9c4\ud1b5\uc81c\uac00 \ub354 \ub9ce\uc774 \uc0ac\uc6a9\ub418\uace0 \uc788\ub2e4. \uc774\ubd80\ud504\ub85c\ud39c \uacc4\uc5f4 \uc9c4\ud1b5\uc81c\uc778\u00a0<a class=\"wiki-link-internal\" title=\"\uc560\ub4dc\ube4c\" href=\"https:\/\/namu.wiki\/w\/%EC%95%A0%EB%93%9C%EB%B9%8C\">\uc560\ub4dc\ube4c<\/a>\uc774 2010\ub144 \ud0c0\uc774\ub808\ub180\uc744 \uc81c\uce58\uace0 \uc138\uacc4 \uc810\uc720\uc728 1\uc704\ub97c \ucc28\uc9c0\ud558\uc5ec \ud604\uc7ac\uc5d0 \uc774\ub974\uace0 \uc788\ub2e4. \ub610 \ub450 \uac00\uc9c0 \uc131\ubd84 \ubaa8\ub450 \ubd80\uc791\uc6a9\uc774 \uc788\uae30 \ub54c\ubb38\uc5d0 \ud574\uc678\uc5d0\uc11c\ub294 \uc544\uce68\uc5d0\ub294 \ud0c0\uc774\ub808\ub180, \uc624\ud6c4\uc5d0\ub294 \uc560\ub4dc\ube4c \uc774\ub7f0 \uc2dd\uc73c\ub85c \ub450 \uac00\uc9c0\ub97c \ubc88\uac08\uc544 \ubcf5\uc6a9\ud558\ub294 \uc6a9\ubc95\uc744 \uad8c\uc7a5\ud558\ub294 \uacbd\uc6b0\ub3c4 \ub9ce\ub2e4\uace0 \ud55c\ub2e4.<\/p>\n<\/div>\n<p class=\"wiki-heading\"><a id=\"s-2\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#toc\">2.<\/a>\u00a0\uc57d\uc73c\ub85c \uc4f0\uc774\uae30\uae4c\uc9c0<\/p>\n<div class=\"wiki-heading-content\">\n<p>\uc131\ubd84\uba85\uc740 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c(Acetaminophen), \ub610\ub294 \ud30c\ub77c\uc138\ud0c0\ubab0(Paracetamol). \ud55c\uad6d, \ubbf8\uad6d\uc5d0\uc11c\ub294 \ubcf4\ud1b5 \uc804\uc790\ub85c \ub9ce\uc774 \uc54c\ub824\uc9c4 \ud3b8\uc774\ub098, \uc601\ubb38\u00a0<a class=\"wiki-link-internal\" title=\"\uc704\ud0a4\ubc31\uacfc\" href=\"https:\/\/namu.wiki\/w\/%EC%9C%84%ED%82%A4%EB%B0%B1%EA%B3%BC\">\uc704\ud0a4\ubc31\uacfc<\/a>\uc5d0\ub294\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/en.wikipedia.org\/wiki\/Paracetamol\" href=\"http:\/\/en.wikipedia.org\/wiki\/Paracetamol\" target=\"_blank\" rel=\"noopener noreferrer\">\ud6c4\uc790\uc758 \uc774\ub984\uc73c\ub85c<\/a>\u00a0\ub4f1\ub85d\ub418\uc5b4 \uc788\ub2e4.\u00a0<strong>Para<\/strong>-A<strong>cet<\/strong>yl<strong>am<\/strong>inophen<strong>ol<\/strong>\u00a0\uc774\ub0d0 Para-<strong>Acet<\/strong>yl<strong>amino<\/strong><strong>phen<\/strong>ol \uc774\ub0d0\uc758 \ucc28\uc774.\u00a0<del>\ud0c0\uc774\ub808\ub180\uc740 Para-Ace<strong>tyl<\/strong>aminolhep<strong>enol<\/strong><\/del><\/p>\n<p>\ud0c0\uc774\ub808\ub180 \ud648\ud398\uc774\uc9c0\uc5d0 \ub530\ub974\uba74, \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc740 \uc544\uc138\ud2b8\uc544\ub2d0\ub9ac\ub4dc(acetanilide)<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-5\" data-original-title=\"\"><span id=\"rfn-5\" class=\"target\"><\/span>[5]<\/a>\uc758 \ucc98\ubc29\uc73c\ub85c\ubd80\ud130 \ubc1c\uacac\ub418\uc5c8\ub2e4. 19\uc138\uae30 \ub9d0\uc5d0 \ud504\ub791\uc2a4 \uc758\uc0ac\uc5d0 \uc758\ud574 \uadf8 \ud6a8\uacfc\ub97c \ubc1c\uacac\ud558\uac8c \ub418\ub294\ub370, \uc0ac\uc2e4 \uc774\uac8c \uc798\ubabb \ucc98\ubc29\ub41c(&#8230;) \uc57d\uc774\uc5c8\ub2e4. \ubcf8\ub798\u00a0<strong>\ub098\ud504\ud0c8\ub80c<\/strong><del>\uc774\ubcf4\uc2dc\uc624, \uc758\uc0ac\uc591\ubc18<\/del><a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-6\" data-original-title=\"\"><span id=\"rfn-6\" class=\"target\"><\/span>[6]<\/a>\uc744 \ucc98\ubc29\ud558\ub824\uace0 \ud588\ub294\ub370 \uc57d\uad6d\uc758 \uc2e4\uc218\ub85c \uc57d\uc774 \uc798\ubabb \uc640\uc11c \ud658\uc790\uac00 \uc878\uc9c0\uc5d0 \uc2e4\ud5d8\ub300\uc0c1\uc774 \ub418\uc5b4\ubc84\ub9b0 \uac83. \uadf8\ub798\ub3c4 \ud6a8\uacfc\uac00 \uc788\uc5c8\uc73c\ubbc0\ub85c \ub2e4\ud589.<\/p>\n<p>\uc774\ud6c4 \uafb8\uc900\ud55c \uc5f0\uad6c\ub97c \ud1b5\ud574 \ub3c5\uc77c\uc5d0\uc11c \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc758 \ud569\uc131\uc5d0 \uc131\uacf5, \uc774\ud6c4 \uc601\uad6d\uc5d0\uc11c \uadf8 \ud6a8\ub2a5\uc774 \uc785\uc99d\ub41c\ub2e4.<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-7\" data-original-title=\"\"><span id=\"rfn-7\" class=\"target\"><\/span>[7]<\/a><\/p>\n<\/div>\n<p class=\"wiki-heading\"><a id=\"s-3\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#toc\">3.<\/a>\u00a0\ud6a8\ub2a5, \ud6a8\uacfc<\/p>\n<div class=\"wiki-heading-content\">\n<p>\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc740 \uc778\uccb4\uc5d0 \ud1b5\uc99d\uc744 \uc720\ubc1c\ud558\ub294 \ubb3c\uc9c8\uc778 \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518\uc744 \uc81c\uac70\ud558\uc5ec \ud1b5\uc99d\uc744 \ucc28\ub2e8\ud558\uace0 \uc5f4\uc744 \ub0b4\ub9ac\ub294\ub370 \ub2e4\ub978 \uc9c4\ud1b5\uc81c\uc5d0 \ube44\ud558\uc5ec \ud6a8\uacfc\ub3c4 \uc88b\uc744 \ubfd0\ub354\ub7ec \ud56d\uc751\uace0\uc131\uc774 \uac15\ud558\uc5ec \uc704\uada4\uc591, \uc704\ucd9c\ud608 \ub4f1\uc758 \ubd80\uc791\uc6a9\uc744 \uc77c\uc73c\ud0a4\ub294\u00a0<a class=\"wiki-link-internal\" title=\"\uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0\">\uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0<\/a>\uc774\ub098 \uc54c\ub808\ub974\uae30\ub97c \uc9c0\ub2cc \uc0ac\ub78c\uc5d0\uac8c\ub294 \uce58\uba85\uc801\uc778 \uacb0\uacfc\ub97c \uc77c\uc73c\ud0a4\ub294\u00a0<a class=\"wiki-link-internal\" title=\"\uc774\ubd80\ud504\ub85c\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EC%9D%B4%EB%B6%80%ED%94%84%EB%A1%9C%ED%8E%9C\">\uc774\ubd80\ud504\ub85c\ud39c<\/a>\uacfc \ub2e4\ub974\uac8c \uc544\ub798 \uc11c\uc220\ud55c \ub0b4\uc6a9\uc744 \uc81c\uc678\ud558\uace0\ub294 \ubd80\uc791\uc6a9\uc774 \uac70\uc758 \uc5c6\ub2e4. \uac00\uc7a5 \uc57d\ud6a8\uac00 \uc138\ub2e4\uace0 \ud560 \uc21c \uc5c6\uc73c\ub098 \uc911\uac04 \uc774\uc0c1\uc740 \uac00\uace0 \uac00\uc7a5 \ubb34\ub09c\ud558\ub2e4 \ud560 \uc218 \uc788\ub294 \uc9c4\ud1b5\uc81c. \ud2b9\ud788 \uc77c\ubc18\uc57d\uc73c\ub85c\uc11c \uc811\uadfc\uc131\uc774 \ub192\uc740 \uac83\ub3c4 \uc7a5\uc810.<\/p>\n<p>\ub2e4\ub9cc \uc900\uc218\ud55c \uc9c4\ud1b5\u00b7\ud574\uc5f4 \uc131\ub2a5\uc5d0 \ube44\ud574 \uc77c\ubc18\uc801\uc778 NSAID\uacc4\uc5f4\uacfc\ub294 \ub2ec\ub9ac \uc18c\uc5fc \ud6a8\uacfc\ub294 \uac70\uc758 \uc5c6\ub294 \uc218\uc900\uc774\uba70<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-8\" data-original-title=\"\"><span id=\"rfn-8\" class=\"target\"><\/span>[8]<\/a>\u00a0\uc9c4\ud1b5 \ud6a8\uacfc\ub3c4\u00a0<a class=\"wiki-link-internal\" title=\"\ub098\ud504\ub85d\uc13c\" href=\"https:\/\/namu.wiki\/w\/%EB%82%98%ED%94%84%EB%A1%9D%EC%84%BC\">\ub098\ud504\ub85d\uc13c<\/a>\u00a0\ub4f1\uc758 \uc9c4\ud1b5\uc81c\uac00 \ub354 \uac15\ud558\ub2e4. \ud558\uc9c0\ub9cc \uc704\uc7a5 \uc7a5\uc560 \ub4f1\uc758 \ubd80\uc791\uc6a9 \uc6b0\ub824\uac00 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774 \ub9e4\uc6b0 \ub0ae\uc544 \ubcf5\ud569\uc81c \ub4f1\uc5d0 \ub300\ud55c \ubc94\uc6a9\uc131\uc740 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774 \uc6b0\uc138\ud558\ub2e4. \uc774 \ub54c\ubb38\uc5d0 \uac10\uae30\ub85c \uc778\ud55c \uac00\ubcbc\uc6b4 \ud1b5\uc99d \uc644\ud654 \ubc0f \ud574\uc5f4\uc81c\ub85c \ub110\ub9ac \uc0ac\uc6a9\ub41c\ub2e4. \ub274\uc9c8\ub79c\ub4dc\uc5d0\uc11c\ub294 \ub18d\ub2f4 \uc0bc\uc544 \ub9cc\ubcd1\ud1b5\uce58\uc57d\uc774\ub77c\uace0\ub3c4 \ubd80\ub978\ub2e4\u00a0<a class=\"wiki-link-internal\" title=\"\uce74\ub354\ub77c\" href=\"https:\/\/namu.wiki\/w\/%EC%B9%B4%EB%8D%94%EB%9D%BC\">\uce74\ub354\ub77c<\/a><a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-9\" data-original-title=\"\"><span id=\"rfn-9\" class=\"target\"><\/span>[9]<\/a>. \uc0ac\uc2e4 \uc774\ub7f0 \ubd80\ub958 \uc758\uc57d\ud488\uc740 \ud6a8\ub2a5 \ubd80\ubd84\uc744 \uc77d\uc5b4\ubcf4\uba74 \ub204\uac00 \ubd10\ub3c4 \ub9cc\ubcd1\ud1b5\uce58\uc57d \uac19\uc740 \ub290\ub08c\uc774 \ub4e4\uac8c \ub41c\ub2e4&#8230;<\/p>\n<p><a class=\"wiki-link-internal\" title=\"\uce74\ud398\uc778\" href=\"https:\/\/namu.wiki\/w\/%EC%B9%B4%ED%8E%98%EC%9D%B8\">\uce74\ud398\uc778<\/a>\uc744 \uc77c\uc815\ub7c9 \uac19\uc774 \uc12d\ucde8\ud558\uba74 \ud6a8\uacfc\uac00 \uc99d\ub300\ub41c\ub2e4.(\uc774\ub97c \uc57d\ub9ac\ud559\uc801\uc73c\ub85c\ub294 \uc0c1\uc2b9\ud6a8\uacfc\ub77c\uace0 \ud55c\ub2e4.) \uc77c\ubc18\uc801\uc73c\ub85c \uce74\ud398\uc778 \ud568\ub7c9\uc740 50mg \uc804\ud6c4\uac00 \uac00\uc7a5 \ud6a8\uacfc\uac00 \uc88b\uace0 \uadf8\ubcf4\ub2e4 \ub9ce\uc544\ubd10\uc57c \ub354 \ud070 \ud6a8\uacfc\uac00 \ub098\uc624\uc9c0\ub294 \uc54a\ub294\ub2e4\uace0 \uc54c\ub824\uc838 \uc788\ub2e4.<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-10\" data-original-title=\"\"><span id=\"rfn-10\" class=\"target\"><\/span>[10]<\/a>\u00a0\uc2e4\uc81c\ub85c \uc2dc\uc911 \uc720\ud1b5\ub418\ub294 \uc9c4\ud1b5\uc81c \uc911\uc5d0 \ub9ce\uc740 \uc218\uac00 \uce74\ud398\uc778\uacfc \ud63c\ud569\ub41c \uc81c\uc81c\ub4e4\uc774\ub2e4.<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-11\" data-original-title=\"\"><span id=\"rfn-11\" class=\"target\"><\/span>[11]<\/a>\u00a0\uc774\ub807\uac8c \ud22c\uc5ec\ud558\uba74 \uac19\uc740 \uc591\uc758 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc744 \ud22c\uc5ec\ud588\uc744 \ub54c \ub354 \ud6a8\uacfc\uac00 \uc88b\uace0, \ubc18\ub300\ub85c \ub9d0\ud558\uba74 \uac19\uc740 \ud6a8\uacfc\ub97c \ubcf4\uae30 \uc704\ud574\uc11c \ud22c\uc5ec\ud574\uc57c \ud560 \uc591\uc774 \uc801\uae30 \ub54c\ubb38\uc5d0 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc758 \ubd80\uc791\uc6a9\uc744 \uc904\uc774\ub294 \ubaa9\uc801\uc73c\ub85c \ud65c\uc6a9\uc774 \uac00\ub2a5\ud558\ub2e4. \ub2e4\ub9cc \uce74\ud398\uc778\uc5d0 \ubbfc\uac10\ud55c \uc0ac\ub78c\uc740\u00a0<strong>\uce74\ud398\uc778\uc758 \ubd80\uc791\uc6a9\uc774 \uc0c8\ub85c \uc0dd\uae30\ub294 \uac83\uc774\ub2c8<\/strong>\u00a0\ubb34\uc870\uac74 \uc88b\ub2e4\uace0 \ud560 \uc218\ub294 \uc5c6\ub2e4. \ub54c\ubb38\uc5d0 \uc624\ud788\ub824 \uce74\ud398\uc778\uc774 \ub4e4\uc9c0 \uc54a\uc740 \uc9c4\ud1b5\uc81c\ub77c\uace0 \uad11\uace0\ud558\ub294 \uacbd\uc6b0\ub3c4 \uc788\ub2e4. \uac01\uac01 \uc7a5\ub2e8\uc810\uc774 \uc788\ub294 \uc148.<\/p>\n<p>\ub367\ubd99\uc774\uc790\uba74 \uc885\ud569\uac10\uae30\uc57d\uc5d0\uc11c\ub3c4 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uacfc \uce74\ud398\uc778\uc774 \uac19\uc774 \ub4e0 \uacbd\uc6b0\uac00 \uc788\ub294\ub370 \uc774\uac74 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc758 \uc0c1\uc2b9\uc791\uc6a9\ub3c4 \uc788\uc9c0\ub9cc \ud56d\ud788\uc2a4\ud0c0\ubbfc\uc81c(\uc8fc\ub85c \ucf54\uac10\uae30 \uc644\ud654\uc6a9\uc73c\ub85c \ub4e4\uc5b4\uac04\ub2e4)\uc5d0 \uc758\ud55c \uc878\uc74c \uc720\ubc1c \ubd80\uc791\uc6a9\uc744 \uc870\uae08\uc774\ub098\ub9c8 \uc644\ud654\ud558\uae30 \uc704\ud55c \ubaa9\uc801\ub3c4 \uc788\ub2e4.<\/p>\n<\/div>\n<p class=\"wiki-heading\"><a id=\"s-4\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#toc\">4.<\/a>\u00a0\ud0c0\uc774\ub808\ub180\uc758 \uc774\uc6a9<\/p>\n<div class=\"wiki-heading-content\">\n<p>\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c(AAP)\ub97c \ud568\uc720\ud55c \ub300\ud45c\uc801\uc778 \uc0c1\ud488\uc778 \ud0c0\uc774\ub808\ub180\uc740 \uc138\uacc4\uc5d0\uc11c \uac00\uc7a5 \ub110\ub9ac \uc4f0\uc774\ub294 AAP \ud568\uc720 \uc9c4\ud1b5\uc81c\ub85c \uc0ac\uc2e4\uc0c1 AAP \uc678\uc5d0 \ub2e4\ub978 \ubb3c\uc9c8\uc744 \uc0ac\uc6a9\ud558\uc9c0 \uc54a\uc544 \uac00\uc7a5 \ubd80\uc791\uc6a9\uc774 \uc801\uc740 \uc9c4\ud1b5\uc81c\ub85c \uc54c\ub824\uc838 \uc788\ub2e4. 7\uc138 \uc774\ud558\uc758 \uc5b4\ub9b0\uc774\uc5d0\uac8c\ub3c4 \uc0ac\uc6a9\uc774 \uac00\ub2a5\ud558\uba70 \uc774\ub97c \uc704\ud574 \uc720\uc544\uc6a9 \uc81c\ud488\uc774 \ubcc4\ub3c4\ub85c \uc874\uc7ac\ud55c\ub2e4. \uc77c\ubc18\uc801\uc73c\ub85c \ud55c\uad6d\uc5d0\uc11c \uc131\uc778\uc6a9\uc73c\ub85c \uc0ac\uc6a9\ub418\ub294 \uc6a9\ub7c9\uc740 500mg\uc73c\ub85c \uc131\uc778\uc758 \uacbd\uc6b0 4~6\uc2dc\uac04\uc744 \uc8fc\uae30\ub85c 1~2\uc815 \ubcf5\uc6a9(\ud558\ub8e8 \ucd5c\ub300 8\uc815)\uc774 \uac00\ub2a5\ud558\ub2e4.<\/p>\n<p>\ucd5c\uadfc \uc544\uc2a4\ud53c\ub9b0\uc774 \ub1cc\uc878\uc911<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-12\" data-original-title=\"\"><span id=\"rfn-12\" class=\"target\"><\/span>[12]<\/a>\uc744 \uc57c\uae30\ud55c\ub2e4\ub294 \uc8fc\uc7a5\uc774 \uc81c\uae30\ub428\uc5d0 \ub530\ub77c \ubcf4\ub2e4 \uc548\uc804\ud558\uace0 \ud6a8\uacfc\uc801\uc778 \ud574\uc5f4 \uc9c4\ud1b5\uc81c\ub97c \ucc3e\ub294\ub2e4\uba74 \uc774\uac83\uc744 \ucd94\ucc9c.<\/p>\n<p>\ub9c8\uc57d\uc131\uc9c4\ud1b5\uc81c\uc640 \ubcf5\ud569\ud574\uc11c \uc0ac\uc6a9\ud558\uba74 \uc57d\ud6a8\uac00 \uc62c\ub77c\uac04\ub2e4. \ub9c8\uc57d\uc131 \uc9c4\ud1b5\uc81c\uc640 \ubcf5\ud569\ud574\uc11c \ubd80\uc791\uc6a9\uc740 \uc904\uc774\uace0 \uc57d\ud6a8\ub294 \uac19\uc740 \uc6a9\ub7c9\uc758 \ub9c8\uc57d\uc131\uc9c4\ud1b5\uc81c\ubcf4\ub2e4 \uc62c\ub9ac\ub294 \uc6a9\ub3c4\ub85c \uc0ac\uc6a9\ub418\uace0, \uc2e4\uc81c\ub85c \ub9c8\uc57d\uc131 \uc9c4\ud1b5\uc81c\uc640 \uc11e\uc778 \ubcf5\ud569\uc81c\uc81c\uac00 \uc5ec\ub7ec \uc885\ub958 \ucd9c\uc2dc\ub418\uc5b4 \uc788\ub2e4. \uadf8\uc911 \uc720\uba85\ud55c \uac74 \uc694\uc998 \ub9ce\uc774 \ucc98\ubc29\ub418\uace0 \uc788\ub294 \uc6b8\ud2b8\ub77c\uc14b. \uc6b8\ud2b8\ub77c\uc14b\uc740 \ud2b8\ub77c\ub9c8\ub3cc\uc774\ub77c\ub294 \uc544\ud3b8\uacc4 \uc9c4\ud1b5\uc81c\uc640 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c \ubcf5\ud569\uc81c\uc81c\uc774\ub2e4. (\ud2b8\ub77c\ub9c8\ub3cc\uc740 \uc758\uc874\uc131\uc774 \uc57d\ud55c \ud3b8\uc774\ub77c \ub9c8\uc57d\ub958 \uad00\ub9ac \ub300\uc0c1\uc740 \uc544\ub2c8\ub2e4)<\/p>\n<p>2009\ub144\uacbd\u00a0<strong>\uc2e0\uc885 \ud50c\ub8e8<\/strong>\uac00 \uc720\ud589\ud560 \ub54c, \uc774\uac83\uc774 \ubc31\uc2e0\uc758 \ud6a8\ub2a5\uc744 \ub5a8\uc5b4\ud2b8\ub9b0\ub2e4\ub294 \ub274\uc2a4\uac00 \ub098\uc654\ub2e4.<\/p>\n<p><a class=\"wiki-link-internal\" title=\"\uc5ec\uc131\" href=\"https:\/\/namu.wiki\/w\/%EC%97%AC%EC%84%B1\">\uc5ec\uc131<\/a>\uc758 \uacbd\uc6b0\u00a0<strong><a class=\"wiki-link-internal\" title=\"\uc0dd\ub9ac\" href=\"https:\/\/namu.wiki\/w\/%EC%83%9D%EB%A6%AC\">\uc0dd\ub9ac<\/a>\ud1b5<\/strong>\uc744 \uacac\ub38c\ub0b4\uae30 \uc704\ud574 \uc9c4\ud1b5\uc81c\ub97c \uc774\uc6a9\ud560 \ub54c\uac00 \uc788\ub2e4. \ud0c0\uc774\ub808\ub180\uc740 \ub0b4\uc131\uc774 \uc0dd\uae30\uc9c0 \uc54a\uc544 \uc0dd\ub9ac\ud1b5 \ub54c \uba39\uae30\uc5d0 \uc801\ud569\ud558\ub2e4\uace0 \ud558\uc9c0\ub9cc \uc0ac\uc2e4 \ubaa8\ub4e0\u00a0<a class=\"wiki-link-internal\" title=\"NSAID\" href=\"https:\/\/namu.wiki\/w\/NSAID\">NSAID<\/a>(\ub300\ubd80\ubd84\uc758 \ud574\uc5f4\uc9c4\ud1b5\uc81c)<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-13\" data-original-title=\"\"><span id=\"rfn-13\" class=\"target\"><\/span>[13]<\/a>\ub294 \ub0b4\uc131\uc774 \uc0dd\uae30\uc9c0 \uc54a\ub294\ub2e4. \ud55c\ud3b8 \uc6b0\uba3c\uc2a4 \ud0c0\uc774\ub808\ub180\uc774 \ub530\ub85c \uc788\ub294\ub370, \ucc28\uc774\uc810\uc740 \uc77c\ubc18 \ud0c0\uc774\ub808\ub180\uc5d0 \ube44\ud574 \ubd80\uae30\ub97c \uacbd\uac10\ud558\uae30 \uc704\ud558\uc5ec \uc774\ub1e8\uc81c\uc778 \ud30c\ub9c8\ube0c\ub86c\uc744 \ucca8\uac00\ud55c \uac83. \uc0dd\ub9ac\ud1b5\uc740 \uc5ec\ub7ec \uae30\uc804\uc73c\ub85c \uc77c\uc5b4\ub098\ub294\ub370, \uc790\uad81\ud3c9\ud65c\uadfc\uc758 \uae34\uc7a5\uc73c\ub85c \uc778\ud574 \uc0dd\ub9ac\ud1b5\uc774 \uc77c\uc5b4\ub098\ub294 \uacbd\uc6b0 \ud0c0\uc774\ub808\ub180\uc740 \uc9c4\ud1b5 \ud6a8\uacfc\uac00 \ub2e4\ub978 \ubb3c\uc9c8\uc5d0 \ube44\ud574 \ud06c\uc9c0 \uc54a\uc73c\ubbc0\ub85c \ud6a8\uacfc\uac00 \uc57d\ud558\ub2e4. \uc77c\ubc18\uc801\uc778 \ud1b5\uc99d\uc6d0\uc778\uc774 \uccb4\ub0b4 \uc9d1\uc911\ub41c \uc218\ubd84\uc774\uace0 \ud1b5\uc99d\ubd80\uc704\uc5d0 \ube44\ub1e8\uae30\uac00 \uadfc\uc811\ud574 \uc788\uc5b4 \uc8fc\ubcc0\uc758 \uc218\ubd84\uc744 \ubc30\ucd9c\ud558\uc5ec \ud1b5\uc99d\uc744 \ubcf4\ub2e4 \ube60\ub974\uac8c \uc644\ud654\uc2dc\ucf1c \uc900\ub2e4. \ub530\ub77c\uc11c \uc0dd\ub9ac\ud1b5\uc778 \uacbd\uc6b0\uc5d0\ub294 \uc5ec\uc131\uc6a9 \ud0c0\uc774\ub808\ub180\uc744 \uba39\ub294 \uac83\uc774 \uc88b\uc744 \uc218 \uc788\ub2e4. \ub2e4\ub9cc \uc0dd\ub9ac\ud1b5\uc73c\ub85c\ub9cc \ubcf4\uba74 \uc77c\ubc18 \ud0c0\uc774\ub808\ub180\ubcf4\ub2e4\ub294 \uc774\ubd80\ud504\ub85c\ud39c\uc744 \ub9ce\uc774 \uc4f4\ub2e4. (\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c &#8211; mild \/ \uc774\ubd80\ud504\ub85c\ud39c &#8211; mild to moderate)<\/p>\n<p>\uad50\uc815\uce58\uacfc\uc5d0\uc11c\ub3c4 \ubcc4\ub3c4\ub85c \uc9c4\ud1b5\uc81c\ub97c \ucc98\ubc29\ud558\uc9c0 \uc54a\ub294 \uacbd\uc6b0\uc5d0 \ud658\uc790\ub4e4\uc5d0\uac8c \uc544\ud504\uba74 \ud0c0\uc774\ub808\ub180\uc744 \uba39\uc73c\ub77c\uace0 \ud55c\ub2e4. \uac00\uc7a5 \ubd80\uc791\uc6a9\uc774 \uc5c6\ub294 \ubb3c\uc9c8\uc774\uace0 \uc27d\uac8c \uad6c\ud560 \uc218 \uc788\uc73c\uba70 \uc77c\ubc18\uc801\uc73c\ub85c \uc54c\ub824\uc9c4 \ub450\ud1b5 \uc678\uc5d0 \uac70\uc758 \ubaa8\ub4e0 \ud1b5\uc99d\uc5d0\ub3c4 \uc801\uc6a9\uc774 \uac00\ub2a5\ud558\uae30 \ub54c\ubb38. \ub2e8, \uce58\ud1b5\uacfc \uac19\uc740 \uac15\ud55c \ud1b5\uc99d\uc5d0 \uc0ac\uc6a9\ud558\ub294 \ub85d\uc18c\ud504\ub85c\ud39c\uac19\uc740 \uac15\ud55c \uc9c4\ud1b5\uc81c\ub3c4 \uc788\uae30 \ub54c\ubb38\uc5d0 \uaf2d \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\ub9cc \ucc98\ubc29\ud558\ub294 \uac83\uc740 \uc544\ub2c8\ub2e4.<\/p>\n<p>\ub124\uc774\uc120 \ub4dc\uc648(Nathan Dewall)\uc774\ub77c\ub294 \ud559\uc790<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-14\" data-original-title=\"\"><span id=\"rfn-14\" class=\"target\"><\/span>[14]<\/a>\uc758 \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74\u00a0<strong>\uc678\ub85c\uc6c0<\/strong>\ub3c4 \uc9c4\uc815\uc2dc\ud0a4\ub294 \ud6a8\uacfc\uac00 \uc788\ub2e4\uace0 \ud55c\ub2e4. \ub1cc\uc5d0\uc11c \uace0\ud1b5\uc744 \ub290\ub084 \ub54c \ud65c\uc131\ud654\ub418\ub294 \ubd80\uc704\uc640 \uc678\ub85c\uc6c0\uc73c\ub85c \ud65c\uc131\ud654\ub418\ub294 \ubd80\uc704\uac00 \uac19\uae30 \ub54c\ubb38\uc774\ub77c\uace0. \uc774\ub294\u00a0<a class=\"wiki-link-internal\" title=\"\uc0ac\ud68c\uc2ec\ub9ac\ud559\" href=\"https:\/\/namu.wiki\/w\/%EC%82%AC%ED%9A%8C%EC%8B%AC%EB%A6%AC%ED%95%99\">\uc0ac\ud68c\uc2ec\ub9ac\ud559<\/a>\uc5d0\u00a0<a class=\"wiki-link-internal\" title=\"\ub1cc\uacfc\ud559\" href=\"https:\/\/namu.wiki\/w\/%EB%87%8C%EA%B3%BC%ED%95%99\">\ub1cc\uacfc\ud559<\/a>\uc774 \uacb0\ud569\ub418\uba74\uc11c \uc54c\ub824\uc9c4 \ub300\ud45c\uc801\uc778 \uc131\uacfc\ub85c, \ud559\uacc4\uc640 \ub300\uc911\uc758 \ub9ce\uc740 \uc774\ubaa9\uc744 \ub04c\uc5c8\ub2e4. \uc989\u00a0<a class=\"wiki-link-internal\" title=\"\uc2e4\uc5f0\" href=\"https:\/\/namu.wiki\/w\/%EC%8B%A4%EC%97%B0\">\uc2e4\uc5f0<\/a>\uc774\ub098\u00a0<a class=\"wiki-link-internal\" title=\"\uc655\ub530\" href=\"https:\/\/namu.wiki\/w\/%EC%99%95%EB%94%B0\">\uc655\ub530<\/a>\ub85c \uad34\ub85c\uc6cc\ud558\ub294 \uc0ac\ub78c\ub4e4\uc5d0\uac8c \uc9c4\ud1b5\uc81c\ub97c \ucc98\ubc29\ud558\ub294 \uac83\uc774 \uc5b4\ub290 \uc815\ub3c4 \ub3c4\uc6c0\uc774 \ub41c\ub2e4\ub294\u00a0<a class=\"wiki-link-internal\" title=\"\ucda9\uacf5\uae7d\" href=\"https:\/\/namu.wiki\/w\/%EC%B6%A9%EA%B3%B5%EA%B9%BD\">\ucda9\uacf5\uae7d<\/a>\uc2a4\ub7ec\uc6b4 \uc5f0\uad6c\uacb0\uacfc\uac00 \ub098\uc628 \uac83. \uc5ec\uae30\uc5d0 \uadf8\uce58\uc9c0 \uc54a\uace0 \ub354 \ub098\uc544\uac00, \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774 \uae30\uc068\uacfc \uac19\uc740 \uc5ec\ub7ec \uac10\uc815\ub4e4\uc744 \ubb34\ub514\uac8c \ud560 \uc218 \uc788\ub294 \ub370\ub2e4 \uc2ec\uc9c0\uc5b4 \ud0c0\uc778\uc5d0 \ub300\ud55c \uac10\uc815\uc774\uc785(empathy)\uae4c\uc9c0 \uc57d\ud558\uac8c \ub9cc\ub4e0\ub2e4\ub294 \ud6c4\uc18d\uc5f0\uad6c\ub3c4 \ub098\uc654\ub2e4. (<a class=\"wiki-link-external\" title=\"http:\/\/www.yonhapnews.co.kr\/bulletin\/2016\/05\/11\/0200000000AKR20160511056500009.HTML?input=1195m\" href=\"http:\/\/www.yonhapnews.co.kr\/bulletin\/2016\/05\/11\/0200000000AKR20160511056500009.HTML?input=1195m\" target=\"_blank\" rel=\"noopener noreferrer\">\uad00\ub828 \uae30\uc0ac<\/a>)<\/p>\n<p>\ub2e8\uc810\uc774 \uc788\ub2e4\uba74 \ub2e8\uc77c \uc9c4\ud1b5\uc81c\ub77c \ub2e8 \ud55c \uac00\uc9c0 \uc131\ubd84\uc73c\ub85c \uc9c4\ud1b5\ud6a8\uacfc\ub97c \ub0b4\uc57c \ud558\ub2c8 \ud310\ub9e4\uc6a9 \uc9c4\ud1b5\uc81c\ub4e4 \uc911\uc5d0\uc11c\ub3c4 \uc57d\ud6a8\uac00 \uadf8\ub9ac \uac15\ud55c \ud3b8\uc740 \uc544\ub2c8\ub77c\ub294 \uac83\uc774\ub2e4. \uc0c1\ub2f9\ud788 \uac15\ud55c \ud1b5\uc99d\uc774\ub098 \uc624\ub798 \uc9c0\uc18d\ub418\ub294 \ud1b5\uc99d\uc5d0 \uc0ac\uc6a9\ud558\uae30\uc5d0\ub294 \ubd80\uc801\ud569\ud560 \uc218 \uc788\ub2e4.<\/p>\n<\/div>\n<p class=\"wiki-heading\"><a id=\"s-5\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#toc\">5.<\/a>\u00a0\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774 \ub4e4\uc5b4\uac04 \uc57d<\/p>\n<p class=\"wiki-heading\"><a id=\"s-5.1\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#toc\">5.1.<\/a>\u00a0<a class=\"wiki-link-internal\" title=\"\uc9c4\ud1b5\uc81c\" href=\"https:\/\/namu.wiki\/w\/%EC%A7%84%ED%86%B5%EC%A0%9C\">\uc9c4\ud1b5\uc81c<\/a><\/p>\n<div class=\"wiki-heading-content\">\n<ul class=\"wiki-list\">\n<li>\ud0c0\uc774\ub808\ub180 : 1\uc815 \uc6a9\ub7c9\uc778 610.8mg \uc911 500mg\uc774 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774\uba70, \ub300\uccb4\ub85c \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c \ub2e8\uc77c\uc815\uc81c\ub77c\uace0 \ubcf4\uc544\ub3c4 \ubb34\ubc29\ud558\ub2e4.<\/li>\n<\/ul>\n<div class=\"wiki-indent\">\n<ul class=\"wiki-list\">\n<li>\ud0c0\uc774\ub808\ub180ER\uc11c\ubc29\uc815 : \uc7a5\uae30\uac04 \uc9c4\ud1b5\ud6a8\uacfc\uc720\uc9c0\ub97c \uc704\ud55c \uc11c\ubc29\uc815\uc73c\ub85c\uc11c 2\uc911 \uad6c\uc870\ub85c \ub418\uc5b4 \uc788\uc5b4 \uac89\uba74\uc758 \uc808\ubc18\uc758 \uc6a9\ub7c9\uc774 \uc644\uc804\ud788 \ud761\uc218\ub418\uba74 \uc774\ud6c4 \ub2e8\ubc31\uc9c8 \ub9c9\uc774 \ubd84\ud574\ub418\uc5b4 \uc548\ucabd\uc758 \uc6a9\ub7c9\uc774 \ud761\uc218\ub418\uc5b4 \uc57d 2~4\uc2dc\uac04\uc744 \uc8fc\uae30\ub85c \ub450 \ubc88 \uba39\ub294 \uac83\uacfc \ube44\uc2b7\ud55c \ud6a8\uacfc\ub97c \uc9c0\ub2c8\uba70 \uc6a9\ubc95\uc740 \uc704\uc640 \ub3d9\uc77c\ud558\ub2e4. \ub2e8, \uc55e\uc5d0\uc11c \ub9d0\ud588\ub4ef \ucd08\uae30\uc5d0\ub294 \ucd1d \uc6a9\ub7c9\uc758 1\/2 \uc815\ub3c4\uac00 \ud761\uc218\ub418\uae30 \ub54c\ubb38\uc5d0 \uc77c\ubc18\uc801\uc778 \ud0c0\uc774\ub808\ub180\uacfc \uac19\uc740 \ud6a8\uacfc\ub97c \ubcf4\ub824\uba74 650mg\uc9dc\ub9ac\ub294 2\uc54c, 325mg\uc9dc\ub9ac\ub294 4\uc54c\uc744 \ud55c \ubc88\uc5d0 \ubcf5\uc6a9\ud574\uc57c \ud55c\ub2e4. \uc720\ub7fd\uc5d0\uc11c\ub294 \uc774 \uc11c\ubc29\uc815\uc744 \uacfc\ub2e4\ubcf5\uc6a9\uc758 \uc6b0\ub824\ub85c 2018\ub144 3\uc6d4\ubd80\ub85c \ud310\ub9e4\uc911\uc9c0\ud55c\ub2e4\uace0 \ubc1c\ud45c\ud588\ub2e4.<\/li>\n<\/ul>\n<\/div>\n<ul class=\"wiki-list\">\n<li>\uc11c\uc2a4\ud39c<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-15\" data-original-title=\"\"><span id=\"rfn-15\" class=\"target\"><\/span>[15]<\/a>, \ud0c0\uc138\ub180<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-16\" data-original-title=\"\"><span id=\"rfn-16\" class=\"target\"><\/span>[16]<\/a>, \uc138\ud1a0\ud39c \ub4f1 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c \uc81c\uc7ac\ub85c\uc11c \ud0c0\uc774\ub808\ub180\uc758\u00a0<a class=\"wiki-link-internal\" title=\"\uc81c\ub124\ub9ad \uc758\uc57d\ud488\" href=\"https:\/\/namu.wiki\/w\/%EC%A0%9C%EB%84%A4%EB%A6%AD%20%EC%9D%98%EC%95%BD%ED%92%88\">\uc81c\ub124\ub9ad<\/a>(\uce74\ud53c\uc57d)\uc774\ub2e4. \uc81c\ub124\ub9ad\uc774\ub77c\uace0 \ud574\ub3c4 \uc6cc\ub099 \ub9ce\uc774 \uc0dd\uc0b0\ud558\ub294 \uc57d\ud488\uc774\ub77c \ud6a8\ub2a5 \ucc28\uc774\ub294 \uc5c6\ub2e4\uace0 \ubd10\ub3c4 \ub41c\ub2e4.<\/li>\n<\/ul>\n<ul class=\"wiki-list\">\n<li><a class=\"wiki-link-internal\" title=\"\uac8c\ubcf4\ub9b0\" href=\"https:\/\/namu.wiki\/w\/%EA%B2%8C%EB%B3%B4%EB%A6%B0\">\uac8c\ubcf4\ub9b0<\/a>, \ud39c\uc798, \uc0ac\ub9ac\ub3c8-A : 1\uc815 \uc6a9\ub7c9 \uc911 300mg \uc815\ub3c4\uac00 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774\uba70, \uc774\uc18c\ud504\ub85c\ud544\uc548\ud2f0\ud53c\ub9b0 150mg \uc815\ub3c4, \uce74\ud398\uc778 \uc131\ubd84\uc774 \uc57d\uac04 \ud3ec\ud568\ub418\uc5b4 \uc788\ub294 \ubcf5\ud569\uc815\uc81c\uc774\ub2e4. \ub2e4\ub9cc \uc774\uc18c\ud504\ub85c\ud544\uc548\ud2f0\ud53c\ub9b0 \uc131\ubd84\uc758 \uacbd\uc6b0 \uace8\uc218\uc5b5\uc218\uc791\uc6a9\uc5d0 \uc758\ud55c \uacfc\ub9bd\uad6c\uac10\uc18c\uc99d\uacfc \uc7ac\uc0dd\ubd88\ub7c9\uc131\ube48\ud608 \ub4f1\uc758 \ud608\uc561\uc9c8\ud658\uacfc \uc758\uc2dd \uc7a5\uc560, \ud63c\uc218, \uacbd\ub828 \ub4f1\uc758 \ubd80\uc791\uc6a9\uc774 \ubcf4\uace0\ub418\uc5b4 \uc788\uc5b4\uc11c \ubbf8\uad6d \ub4f1\uc5d0\uc11c\ub294 1970\ub144\ub300\ubd80\ud130 \uc0ac\uc6a9\uc774 \uae08\uc9c0\ub41c \uc0c1\ud0dc. AAP \uc678\uc5d0 \ub2e4\ub978 \ubb3c\uc9c8\uc744 \ucca8\uac00\ud55c \uc774\uc720\ub294 \uc9c4\ud1b5\uc791\uc6a9\uc744 \uc99d\uac00\uc2dc\ud0a4\uae30 \uc704\ud568\uc774\ub2e4. \ud39c\uc798\uc758 \uacbd\uc6b0 \uc774\uc18c\ud504\ub85c\ud544\uc548\ud2f0\ud53c\ub9b0 \uc131\ubd84\uc744 \ube7c\uace0 \ub2e4\ub978 \uc57d\uc7ac\ub85c \ub300\uccb4\ud55c &#8216;\ud39c\uc798Q&#8217;\ub97c \uc0c8\ub86d\uac8c \ucd9c\uc2dc \ud6c4, \uae30\uc874 \ud39c\uc798\uc744 \ub9ac\ucf5c\ud558\uace0 \uc788\ub2e4.<\/li>\n<\/ul>\n<ul class=\"wiki-list\">\n<li>\ubbf8\uac00\ud39c, \ub9c8\uc774\ub4dc\ub9b0, \uc774\ub370\uc544 \ub4f1 : \uae34\uc7a5\uc131 \ub450\ud1b5(\uc2a4\ud2b8\ub808\uc2a4\uc131 \ub450\ud1b5),\u00a0<a class=\"wiki-link-internal\" title=\"\ud3b8\ub450\ud1b5\" href=\"https:\/\/namu.wiki\/w\/%ED%8E%B8%EB%91%90%ED%86%B5\">\ud3b8\ub450\ud1b5<\/a>\uc57d\uc73c\ub85c\uc11c \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc744 \uc8fc\uc131\ubd84\uc73c\ub85c \ud558\uba70 \uc548\uc815\uc791\uc6a9\uc744 \ud558\ub294 \ub514\ud074\ub85c\ub784\ud398\ub098\uc874, \ub1cc\ud608\uad00\uc218\ucd95\uc791\uc6a9\uc744 \ud558\ub294 \uc774\uc18c\uba54\ucf11\ud150\ubba4\ucf00\uc774\ud2b8 \ub4f1\uc774 \ubcf5\ud569\ub418\uc5b4\uc788\ub294 \uc57d\uc774\ub2e4. \ub450\ud1b5 \uacc4\uc5f4, \ud2b9\ud788 \ub2e4\ub978 \uc99d\uc0c1\uc744 \ub3d9\ubc18\ud558\ub294 \ud3b8\ub450\ud1b5\uc758 \uacbd\uc6b0 \ud0c0\uc774\ub808\ub180 \uacc4\ud1b5\uc758 \uc57d\ubb3c\ubcf4\ub2e4\ub294 \uc774\ucabd\uc774 \ud6e8\uc52c \ud655\uc2e4\ud55c \ud6a8\uacfc\ub97c \ubcfc \uc218 \uc788\ub2e4.<\/li>\n<\/ul>\n<ul class=\"wiki-list\">\n<li>\ub1cc\uc120 : \uc704 \uc57d\ubb3c\ub4e4\uacfc \uac19\uc774 \uc54c\uc57d \ub0b4\uc9c0 \ubb3c\uc57d\uc774 \uc544\ub2cc \uac00\ub8e8\uc57d\uc73c\ub85c\uc368 \ubc31\uc0c9 \ud639\uc740 \uc587\uc740 \ud669\ubc31\uc0c9\uc744 \ub764\ub2e4 .\uac00\ub8e8\uac00 \uc885\uc774\uc5d0 \uc811\ud600\uc838 \uc788\uace0 1\ud3ec\/1\ucca9\ub2f9 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c 300\/ \uce74\ud398\uc778 \ubb34\uc218\ubb3c 50g \uc815\ub3c4\uc758 \uac00\ub8e8\uc57d\uc774 \ub4e4\uc5b4\uc788\ub2e4. \ud55c\uad6d\uc758 \ucc9c\ud61c\ub2f9\uc81c\uc57d\uc774 \uc81c\uc870\ud588\uc73c\uba70 \uc678\ub798\uc5b4\uac00 \uc544\ub2cc \ud55c\uad6d\uc5b4\ub85c \ub41c \uc57d\ud488\uc774\ub77c \uc5b4\ub974\uc2e0\ub4e4\uc774 \uc790\uc8fc \ucc3e\ub294 \uc57d\ubb3c\uc774\uc9c0\ub9cc \uc0dd\uc18c\ud55c \uc774\ub984 \ub54c\ubb38\uc778\uc9c0 \uc80a\uc740 \uce35\uc740 \uc790\uc8fc \uc0ac\uc6a9\ud558\uc9c0 \uc54a\ub294 \ud3b8. \uce74\ud398\uc778\uc758 \ud568\ub7c9\uc774 \ub9ce\uc740 \uac83\uc740 \uc544\ub2c8\uc9c0\ub9cc \uadf8\ub798\ub3c4 \uce74\ud398\uc778\uc774 \ub4e4\uc5b4\uc788\uae30 \ub54c\ubb38\uc5d0 \ubcf5\uc6a9\uc2dc \ubd80\uc791\uc6a9\uc73c\ub85c \uc704\uc7a5\uc7a5\uc560\uac00 \uc0dd\uae38 \uc218 \uc788\ub2e4.<\/li>\n<\/ul>\n<\/div>\n<p class=\"wiki-heading\"><a id=\"s-5.2\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#toc\">5.2.<\/a>\u00a0<a class=\"wiki-link-internal\" title=\"\uc885\ud569\uac10\uae30\uc57d\" href=\"https:\/\/namu.wiki\/w\/%EC%A2%85%ED%95%A9%EA%B0%90%EA%B8%B0%EC%95%BD\">\uc885\ud569\uac10\uae30\uc57d<\/a><\/p>\n<div class=\"wiki-heading-content\">\n<p>\uc0ac\uc2e4\uc0c1 \ub300\ub2e4\uc218\uc758 \uc885\ud569 \uac10\uae30\uc57d\uc5d0\ub294 \uc774 \uc131\ubd84\uc774 \ub4e4\uc5b4\uac00 \uc788\ub2e4. \uac10\uae30\ub294 \uac70\uc758 \ub300\ubd80\ubd84 \ubc1c\uc5f4 \uc99d\uc0c1\uc774 \ub3d9\ubc18\ud558\uae30\uc5d0 \ud574\uc5f4\uc9c4\ud1b5\uc81c\uac00 \ud544\uc694\ud558\ub2e4. \uc54c\ub824\uc9c4 \ud574\uc5f4\uc9c4\ud1b5\uc81c \uc911 \uadf8\ub098\ub9c8 \uac00\uc7a5 \uc548\uc804\ud558\ub2e4\uace0 \ud310\ub2e8\ud558\uace0 \uc788\uae30\uc5d0, \ub110\ub9ac \uc0ac\uc6a9\ub41c\ub2e4.<\/p>\n<ul class=\"wiki-list\">\n<li>\ud310\ud53c\ub9b0<\/li>\n<li><a class=\"wiki-link-internal\" title=\"\ub098\uc774\ud03c\" href=\"https:\/\/namu.wiki\/w\/%EB%82%98%EC%9D%B4%ED%80%BC\">\ub098\uc774\ud03c<\/a>\u00a0: NyQuil Cold\uc758 \uacbd\uc6b0 30mL\uc5d0 650mg\uc758 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774 \ub4e4\uc5b4\uc788\ub2e4.<\/li>\n<li>\ud0c0\uc774\ub808\ub180 \ucf5c\ub4dc\uc5d0\uc2a4\uc815<\/li>\n<li>\ud30c\ube0c\ub860\uace8\ub4dc : \uc77c\uc81c \uac10\uae30\uc57d\uc774\ub2e4.<\/li>\n<li>\ud654\uc774\ud22c\ubca4 \uc528\ud50c\ub7ec\uc2a4<\/li>\n<\/ul>\n<\/div>\n<p class=\"wiki-heading\"><a id=\"s-6\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#toc\">6.<\/a>\u00a0\ubd80\uc791\uc6a9<\/p>\n<div class=\"wiki-heading-content\">\n<p>\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc740 \ud604\uc874\ud558\ub294 \uc57d\ubb3c \uc911 \uac04\ub3c5\uc131\uc774 \uac00\uc7a5 \ud070 \uc57d\ubb3c \uc911 \ud558\ub098\ub85c \ucd5c\ub300\ubcf5\uc6a9\ub7c9 \uc774\uc0c1\uc744 \ubcf5\uc6a9\ud560 \uacbd\uc6b0 \uc2ec\uac01\ud55c \uac04\uc190\uc0c1\uc744 \ucd08\ub798\ud560 \uc218 \uc788\ub2e4.<\/p>\n<p>\ud558\ub8e8 \ucd5c\ub300 \ud5c8\uc6a9\uce58\ub294 \uc131\uc778\uc744 \uae30\uc900\uc73c\ub85c 4g, \uac04\ub2e8\ud788 \ub9d0\ud574\u00a0<strong>500mg \uae30\uc900 8\uc815<\/strong>\u00a0\ub610\ub294\u00a0<strong>650mg \uae30\uc900 6\uc815 \ubbf8\ub9cc<\/strong>\uc774\ub2e4.<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-17\" data-original-title=\"\"><span id=\"rfn-17\" class=\"target\"><\/span>[17]<\/a><a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-18\" data-original-title=\"\"><span id=\"rfn-18\" class=\"target\"><\/span>[18]<\/a>\u00a0\ub9cc\uc57d \uc774\ub97c \ucd08\uacfc\ud558\uc5ec 24\uc2dc\uac04 \ub0b4 \ubcf5\uc6a9\ub7c9\uc774 10g\uc744 \ucd08\uacfc\ud558\uac70\ub098 \ub2e8 \ud55c \uc54c\uc744 \uc12d\ucde8\ud558\uc600\ub354\ub77c\ub3c4 \ud3c9\uc18c\uc5d0 \uc54c\ucf5c\uc744 3\ub2e8\uc704<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-19\" data-original-title=\"\"><span id=\"rfn-19\" class=\"target\"><\/span>[19]<\/a>\u00a0\uc774\uc0c1 \ub9c8\uc2dc\uac70\ub098 \uc220\uacfc \uac19\uc774 \uc12d\ucde8\ud558\ub294 \uacbd\uc6b0\uc5d0\ub294 \uae09\uc131 \uac04\ubd80\uc804\uc774 \ubc1c\uc0dd\ud560 \uc218 \uc788\ub2e4.<\/p>\n<p>\uc778\uccb4\ub85c \ub4e4\uc5b4\uc628 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc758 5~10% \uc815\ub3c4\ub294 \uac04(\u809d) \uc0b0\ud654\ud658\uc6d0\ud6a8\uc18c\uc758 \uc791\uc6a9\uc73c\ub85c \uc778\ud574 NAPQI\ub77c\ub294, \ubc18\uc751\uc131\uc774 \ucee4\uc11c\u00a0<a class=\"wiki-link-internal\" title=\"\ud65c\uc131\uc0b0\uc18c\" href=\"https:\/\/namu.wiki\/w\/%ED%99%9C%EC%84%B1%EC%82%B0%EC%86%8C\">\ud65c\uc131\uc0b0\uc18c<\/a>\ub97c \ub9ce\uc774 \ub9cc\ub4dc\ub294 \ubb3c\uc9c8\ub85c \ubcc0\ud55c\ub2e4. \ubcf4\ud1b5\uc740 \uc774\ub7ec\ud55c \ubb3c\uc9c8\uc774 \uc0dd\uc131\ub418\ub354\ub77c\ub3c4 \uac04\uc774 \uc2a4\uc2a4\ub85c \ud574\ub3c5\ud558\uae30 \ub54c\ubb38\uc5d0 \ubb38\uc81c\ub418\uc9c0 \uc54a\uc9c0\ub9cc, \uacfc\ub7c9\uc744 \ubcf5\uc6a9\ud560 \uacbd\uc6b0 \uccb4\ub0b4 \ud574\ub3c5\ubb3c\uc9c8\uc778 \uae00\ub8e8\ud0c0\uce58\uc628\uc774 \uc18c\uc9c4\ub418\uba74\uc11c \uac04\uc138\ud3ec\uac00 \ud30c\uad34\ub41c\ub2e4. \uc774 \ub54c\ubb38\uc5d0 \uc885\uc885\u00a0<a class=\"wiki-link-internal\" title=\"\uc790\uc0b4\" href=\"https:\/\/namu.wiki\/w\/%EC%9E%90%EC%82%B4\">\uc790\uc0b4<\/a>\ud560 \ubaa9\uc801\uc73c\ub85c \uc77c\ubd80\ub7ec \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc744 \uc794\ub729 \uc9d1\uc5b4\uba39\ub294 \uc0ac\ub840\ub3c4 \uc788\ub2e4.<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-20\" data-original-title=\"\"><span id=\"rfn-20\" class=\"target\"><\/span>[20]<\/a><a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-21\" data-original-title=\"\"><span id=\"rfn-21\" class=\"target\"><\/span>[21]<\/a>\u00a0\uc5b4\ub5a4 \uc774\uc720\ub85c\ub4e0 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc744 \uacfc\ub2e4\ubcf5\uc6a9\ud55c \uacbd\uc6b0, \ubcd1\uc6d0\uc5d0\uc11c\ub294 \uac04\uc744 \ubcf4\ud638\ud558\uae30 \uc704\ud558\uc5ec N-\uc544\uc138\ud2f8\uc2dc\uc2a4\ud14c\uc778(NAC)\uc774\ub77c\ub294 \ud56d\uc0b0\ud654\ubb3c\uc9c8\uc744 \ud574\ub3c5\uc81c\ub85c \ud22c\uc5ec\ud55c\ub2e4. \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c \uc911\ub3c5 \uc2dc \uac04\uc774 \ub9dd\uac00\uc9c0\ub294 \uac83\uc744 \ub9c9\uc73c\ub824\uba74 8\uc2dc\uac04 \uc774\ub0b4\uc5d0 \ubcd1\uc6d0\uc5d0 \uac00\uc11c \uce58\ub8cc\ub97c \ubc1b\uc544\uc57c \ud55c\ub2e4.<\/p>\n<p>\ub610\ud55c \uac04\uc758 \uc0b0\ud654\ud6a8\uc18c\ub294 \uc54c\ucf54\uc62c\uacfc \uc811\ucd09\ud560\uc218\ub85d \uadf8 \uc791\uc6a9\uc774 \ucee4\uc9c0\uae30 \ub54c\ubb38\uc5d0 \ub354 \ub9ce\uc740 \ub3c5\uc131\ubb3c\uc9c8\uc744 \ub9cc\ub4e4\uc5b4\ub0b8\ub2e4. \ub530\ub77c\uc11c \uc54c\ucf5c\uacfc \ud568\uaed8 \ubcf5\uc6a9\ud560 \uacbd\uc6b0 \uce58\uba85\uc801\uc778 \uac04\uc190\uc0c1\uc744 \uc720\ubc1c\ud560 \uc218\ub3c4 \uc788\uc9c0\ub9cc\u2026 \uc0ac\uc2e4\uc740\u00a0<a class=\"wiki-link-internal\" title=\"\uc18c\uc1a1\ubc29\uc9c0\ubc14\ub78c\" href=\"https:\/\/namu.wiki\/w\/%EC%86%8C%EC%86%A1%EB%B0%A9%EC%A7%80%EB%B0%94%EB%9E%8C\">\uc18c\uc1a1\ubc29\uc9c0<\/a>\ub97c \uc704\ud574 \uc704\ud5d8\uc131\uc744 \uac15\uc870\ud55c \uac83.\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/mabari.kr\/211\" href=\"http:\/\/mabari.kr\/211\" target=\"_blank\" rel=\"noopener noreferrer\">#<\/a>\u00a0\ubb3c\ub860 \uc704\ud5d8\uc131\uc740 \ubd84\uba85\ud788 \uc0c1\uc874\ud558\uba70 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c \uc790\uccb4\uac00 \uac04 \ubd80\ub2f4\uc774 \uc2ec\ud55c \uc57d \uc911 \ud558\ub098\ubbc0\ub85c \uac00\uae09\uc801\uc774\uba74 \uc774 \uc57d\uc744 \uba39\uc744 \ub54c\ub294 \uc220\uc740 \uc790\uc81c\ud558\uc790. \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\ubfd0\ub9cc \uc544\ub2c8\ub77c \ub300\ubd80\ubd84\uc758 \uc57d\uc5d0\ub3c4 \ud574\ub2f9\ub41c\ub2e4. \uc77c\ub840\ub85c \uc870\uc9c0 \ubd80\uc2dc \ub300\ud1b5\ub839\uc758 \uce21\uadfc\uc774\ub358 \ubca0\ub124\ub514\ub294 1993\ub144 \uc815\uc0c1 \uc6a9\ub7c9\uc758 \ud0c0\uc774\ub808\ub180\uc744 4~5\uc77c\uac04 \ubcf5\uc6a9\ud588\ub2e4\uac00 \ud63c\uc218\uc0c1\ud0dc\uc5d0 \ube60\uc838 \uc9c4\ub2e8\ud55c \uacb0\uacfc \uac04\ubd80\uc804\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4. \uac04 \uc774\uc2dd\uc218\uc220\uc744 \ubc1b\uc544 \uc18c\uc0dd\ud55c \uadf8\ub294 \uc81c\uc57d\ud68c\uc0ac\ub97c \uc0c1\ub300\ub85c \uc18c\uc1a1\uc744 \uc81c\uae30\ud558\uc5ec 880\ub9cc \ub2ec\ub7ec\uc758 \ubcf4\uc0c1\uc744 \ubc1b\uc558\ub2e4. \uadf8\ub294 \ub0a0\ub9c8\ub2e4 \uc800\ub141\uc2dd\uc0ac \ub54c\uc5d0 2~4\uc794\uc758 \ud3ec\ub3c4\uc8fc\ub97c \ub9c8\uc168\ub294\ub370 \uc774\uac83\uc774 \uc6d0\uc778\uc774\uc5c8\uc73c\uba70 \uc54c\ucf54\uc62c\uc758 \ubb38\uc81c\ub97c \uc54c\ub9ac\uc9c0 \uc54a\uc740 \uc81c\uc57d\ud68c\uc0ac\uc5d0 \ubcf4\uc0c1\ucc45\uc784\uc774 \ub5a8\uc5b4\uc9c4 \uac83\uc774\ub2e4.\u00a0<del>\ub808\uc54c \uac04\ub3c4\ub451<\/del><\/p>\n<p>\uc774\uc5d0 \ub530\ub77c \ubbf8\uad6d\uc2dd\ud488\uc758\uc57d\uccad(FDA)\uc740 \u201c\ub9e4\uc77c \uc138 \uc794 \uc774\uc0c1 \uc815\uae30\uc801\uc73c\ub85c \uc220\uc744 \ub9c8\uc2dc\ub294 \uc0ac\ub78c\uc740 \uac04 \ub3c5\uc131\uc774 \uc720\ubc1c\ub420 \uc218 \uc788\uc73c\ub2c8 \uc774 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc744 \ubcf5\uc6a9\ud574\uc57c \ud560 \uacbd\uc6b0 \ubc18\ub4dc\uc2dc \uc758\uc0ac\uc640 \uc0c1\uc758\ud574\uc57c \ud55c\ub2e4\u201d\ub294 \ubb38\uad6c\ub97c \uc790\ubc1c\uc801\uc73c\ub85c \uc54c\ub9ac\ub3c4\ub85d \uad8c\uc720\ud558\ub358 \ubc29\uce68\uc744 1998\ub144\uc5d0 \ubcc0\uacbd\ud558\uc5ec \uc758\ubb34\uacbd\uace0\uc0ac\ud56d\uc73c\ub85c \ud45c\uc2dc\ud558\ub3c4\ub85d \ud558\uc5ec \ud604\uc7ac\uc5d0 \uc774\ub974\uace0 \uc788\ub2e4. \uce58\uba85\uc801\uc778 \ubd80\uc791\uc6a9\uc774 \uc5c6\ub2e4\ud574\ub3c4\u00a0<strong>\uc220\uc744 \uc548 \ub9c8\uc2dc\ub294 \uac8c \uc81c\uc77c \uc88b\ub2e4<\/strong>.<\/p>\n<p>\uc784\uc0b0\ubd80\ub3c4 \ube44\uad50\uc801 \uc548\uc2ec\ud558\uace0 \ubcf5\uc6a9\ud560 \uc218 \uc788\ub294 \uc57d\uc73c\ub85c \uc54c\ub824\uc838 \uc788\uc5c8\uc73c\ub098, \ucd5c\uadfc \uc784\uc2e0\uae30\uac04(\ud2b9\ud788 4~6\uac1c\uc6d4\ucc28) \uc911 \uc9c4\ud1b5\uc81c \ubcf5\uc6a9\uc774 \ud1b5\uacc4\uc801\uc73c\ub85c \uc720\uc758\ud558\uac8c \ub0a8\uc790 \ud0dc\uc544\uc758 \uc131\uc801 \ubc1c\ub2ec\uc744 \uc800\ud558\uc2dc\ud0a4\ub294 \uac83(<a class=\"wiki-link-internal\" title=\"\uc7a0\ubcf5\uace0\ud658\" href=\"https:\/\/namu.wiki\/w\/%EC%9E%A0%EB%B3%B5%EA%B3%A0%ED%99%98\">\uc7a0\ubcf5\uace0\ud658<\/a>)\uc774 \uad00\ucc30\ub418\uc5c8\ub2e4\ub294 \uc5f0\uad6c\uacb0\uacfc\uc5d0 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c,\u00a0<a class=\"wiki-link-internal\" title=\"\uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0\">\uc544\uc2a4\ud53c\ub9b0<\/a>,\u00a0<a class=\"wiki-link-internal\" title=\"\uc774\ubd80\ud504\ub85c\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EC%9D%B4%EB%B6%80%ED%94%84%EB%A1%9C%ED%8E%9C\">\uc774\ubd80\ud504\ub85c\ud39c<\/a>\uc774 \ud3ec\ud568\ub418\uc5c8\ub2e4.\u00a0<del>3\ub300 \uc9c4\ud1b5\uc81c\uac00 \ubaa8\ub450\u2026<\/del><a class=\"wiki-link-external\" title=\"http:\/\/articles.latimes.com\/2010\/nov\/08\/news\/la-heb-painkillers-birth-defects-20101108\" href=\"http:\/\/articles.latimes.com\/2010\/nov\/08\/news\/la-heb-painkillers-birth-defects-20101108\" target=\"_blank\" rel=\"noopener noreferrer\">#<\/a>\u00a0\uadf8\ub7ec\ub098 \ubb34\uc870\uac74 \uc57d\uc744 \uba39\uc9c0 \uc54a\uace0 \uace0\uc5f4\ub85c \ubc84\ud2f0\ub294 \uac83\ub3c4 \ud0dc\uc544\uc5d0\uac8c \ud574\uac00 \ub420 \uc218 \uc788\uc73c\ubbc0\ub85c, \ud1b5\uc99d\uc774\ub098 \uc5f4\uc774 \uc788\uc744 \ub54c\ub294 \uc77c\ub2e8 \uc758\uc0ac\uc640 \uc0c1\ub2f4\ud558\ub294 \uac83\uc774 \ubc14\ub78c\uc9c1\ud558\ub2e4.<\/p>\n<p>\uc9c4\ud1b5\uc81c\uc5d0 \uc4f0\uc774\ub294 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774 \ub0a8\uc131 \uc0dd\uc2dd\uae30\ub2a5\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\ub2e4\ub294 \uc5f0\uad6c\uacb0\uacfc\uac00 \ub098\uc654\ub2e4.\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/media.daum.net\/life\/health\/wellness\/newsview?newsId=20160715105948582&amp;RIGHT_LIFE=R9\" href=\"http:\/\/media.daum.net\/life\/health\/wellness\/newsview?newsId=20160715105948582&amp;RIGHT_LIFE=R9\" target=\"_blank\" rel=\"noopener noreferrer\">&#8220;\uc9c4\ud1b5\uc81c \uc8fc\uc131\ubd84 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c, \ub0a8\uc131 \uc0dd\uc2dd\uae30\ub2a5\uc5d0 \uc601\ud5a5&#8221;<\/a>\u00a0<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-22\" data-original-title=\"\"><span id=\"rfn-22\" class=\"target\"><\/span>[22]<\/a><\/p>\n<p>\uacb0\uad6d 2018\ub144 3\uc6d4\ubd80\ub85c \uc720\ub7fd\uc5d0\uc11c\ub294 \uc77c\ubc18 \ud0c0\uc774\ub808\ub180\ubcf4\ub2e4 \uc6a9\ub7c9\uc774 \uc880 \ub354 \ud070 \ud0c0\uc774\ub808\ub180 \uc11c\ubc29\uc815\uc744 \ubcf5\uc6a9\ud558\uba74 \uac04\uc190\uc0c1\uc744 \uc720\ubc1c\ud55c \uc704\ud5d8\uc774 \uc788\ub2e4\uace0 \ubcf4\uace0 \ud310\ub9e4\ub97c \uc911\uc9c0\uc2dc\ucf30\ub2e4. \ud2b9\ud788 \uc11c\ubc29\uc815\uc740 \uc815\ub7c9\uc744 \uc801\ub2f9\ud55c \uac04\uaca9\uc73c\ub85c \ubcf5\uc6a9\ud558\uba74 \uc548\uc804\ud558\uace0 \uc790\uc8fc \ubcf5\uc6a9\ud558\uc9c0 \uc54a\uc544\ub3c4 \ub418\uc5b4 \ud3b8\ub9ac\ud558\uc9c0\ub9cc \ud754\ud788 \ub450\ud1b5 \ud658\uc790\ub4e4\uc774 \ubcf5\uc6a9\ud558\uace0 \uc9c4\ud1b5 \ud6a8\uacfc\uac00 \uae08\ubc29 \uc548 \ub290\uaef4\uc9c0\ub2c8\uae4c \ub610 \ubcf5\uc6a9\ud558\ub294 \ub4f1 \uacfc\ub2e4 \ubcf5\uc6a9\ud558\uae30 \uc26c\uc6cc\uc11c \uc704\ud5d8\ud55c \uac83.\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/news.naver.com\/main\/read.nhn?mode=LSD&amp;mid=sec&amp;sid1=103&amp;oid=018&amp;aid=0004055603\" href=\"http:\/\/news.naver.com\/main\/read.nhn?mode=LSD&amp;mid=sec&amp;sid1=103&amp;oid=018&amp;aid=0004055603\" target=\"_blank\" rel=\"noopener noreferrer\">\uc2dd\uc57d\ucc98,\u00a0<em>\ud0c0\uc774\ub808\ub180 \uc11c\ubc29\uc815, \uc720\ub7fd\uc11c \ud310\ub9e4 \uc911\uc9c0<\/em><\/a><\/p>\n<\/div>\n<p class=\"wiki-heading\"><a id=\"s-6.1\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#toc\">6.1.<\/a>\u00a0\uc624\ub0a8\uc6a9<\/p>\n<div class=\"wiki-heading-content\">\n<p>\ubbf8\uad6d \ud0d0\uc0ac\ubcf4\ub3c4 \ub9e4\uccb4\uc778 \ud504\ub85c\ud37c\ube14\ub9ac\uce74\uc5d0\uc11c \ud0c0\uc774\ub808\ub180\uc758 \uc8fc\uc694 \uc131\ubd84\uc778 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc758 \uc704\ud5d8\uc131\uc5d0 \ub300\ud55c \ud0d0\uc0ac\ubcf4\ub3c4\ub97c \ud588\ub2e4.<\/p>\n<p>\ud574\ub2f9 \ub9c1\ud06c :\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/www.propublica.org\/article\/tylenol-mcneil-fda-use-only-as-directed\" href=\"http:\/\/www.propublica.org\/article\/tylenol-mcneil-fda-use-only-as-directed\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/www.propublica.org\/article\/tylenol-mcneil-fda-use-only-as-directed<\/a>\u00a0,\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/www.propublica.org\/series\/overdose\" href=\"http:\/\/www.propublica.org\/series\/overdose\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/www.propublica.org\/series\/overdose<\/a><br \/>\n\uad00\ub828 \uae30\uc0ac :\u00a0<a class=\"wiki-link-external\" title=\"http:\/\/www.koreadaily.com\/news\/read.asp?page=1&amp;branch=NEWS&amp;source=&amp;category=lifenleisure&amp;art_id=1997153\" href=\"http:\/\/www.koreadaily.com\/news\/read.asp?page=1&amp;branch=NEWS&amp;source=&amp;category=lifenleisure&amp;art_id=1997153\" target=\"_blank\" rel=\"noopener noreferrer\">http:\/\/www.koreadaily.com\/news\/read.asp?page=1&amp;branch=NEWS&amp;source=&amp;category=lifenleisure&amp;art_id=1997153<\/a><\/p>\n<p>\uc9c0\ub09c 10\ub144\uac04 \ubbf8\uad6d\uc5d0\uc11c \ud0c0\uc774\ub808\ub180 \uad00\ub828\uc73c\ub85c 1567\uba85\uc774 \uc0ac\ub9dd\ud55c \uac83\uc73c\ub85c \uc9d1\uacc4\ub418\uc5c8\ub2e4. \uc0ac\ub9dd\uc6d0\uc778\uc740 \uc8fc\uc694\uc131\ubd84\uc778 \u2018\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c(acetaminophen)\u2019 \uacfc\ub2e4\ubcf5\uc6a9\uc73c\ub85c, \uc774 \uc131\ubd84\uc740 \uad8c\uc7a5\ub7c9\uc744 \uc12d\ucde8\ud560 \ub54c\ub294 \uc9c4\ud1b5 \ud6a8\uacfc\uac00 \ub6f0\uc5b4\ub098\uc9c0\ub9cc \uae30\uc900\uce58 \ucd08\uacfc \uc2dc \uce58\uba85\uc801\uc774\ub2e4. \ud2b9\ud788 \uc220\uacfc \ud568\uaed8 \uc12d\ucde8 \ud560 \uacbd\uc6b0, \uac04 \uc190\uc0c1\uc744 \uc720\ubc1c\ud55c\ub2e4. \ub610 \ud0c0\uc774\ub808\ub180\uc740 \uc5b4\ub9b0\uc774\ub97c \uc704\ud55c \uc2dc\ub7fd \ud615\ud0dc\ub85c\ub3c4 \ud310\ub9e4\ub418\uace0 \uc788\uc5b4 \ub354\uc6b1 \uac01\ubcc4\ud55c \uc8fc\uc758\uac00 \uc694\uad6c\ub41c\ub2e4.<\/p>\n<p>\uadf8\ub7f0\ub370 \ubbf8\uad6d\uc5d0\uc11c \ud0c0\uc774\ub808\ub180\uc5d0 \uc758\ud55c \uac04\ub3c5\uc131\uc5d0 \ub300\ud55c \ud55c \uc5f0\uad6c\ub97c \ubcf4\uba74 93\uba85\uc758 \ud658\uc790 \uc911 80\uba85\uc740 \uc790\uc0b4 \ubaa9\uc801\uc73c\ub85c \ubcf5\uc6a9\ud558\uc600\uace0 13\uba85\uc740 \uc9c4\ud1b5 \ubaa9\uc801\uc73c\ub85c \ubcf5\uc6a9 \uc911 \uac04\ub3c5\uc131\uc774 \uc0dd\uacbc\ub2e4.<a class=\"wiki-link-external\" title=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC111182\/\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC111182\/#!po=91.3793\" target=\"_blank\" rel=\"noopener noreferrer\">#<\/a>\u00a0\ubbf8\uad6d\uc5d0\uc11c\ub294 \uc18c\ub9e4\uc810\uc5d0\uc11c 100\uc815 \ud3ec\uc7a5\uc81c\ud488\uc744 \ud310\ub9e4\ud55c\ub2e4.<br \/>\n\uc6b0\ub9ac\ub098\ub77c\uc5d0\uc11c \ub3c5\uc131 \uac04\uc5fc\uc73c\ub85c \uc778\ud55c \uac04\uc774\uc2dd \ud658\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uc5f0\uad6c\uc5d0\uc11c \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774 \uc6d0\uc778\uc774 \ub41c \uac83\uc740 3%\ub85c \ub0ae\uc558\ub2e4. \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\ubcf4\ub2e4 \ud754\ud55c \uc774\uc720\ub85c\ub294 B\ud615\uac04\uc5fc(37%), \ud55c\uc57d\uc7ac(19%), A\ud615\uac04\uc5fc(7%), \uc790\uac00\uba74\uc5ed\uc131\uac04\uc5fc(7%), \uc57d\ubb3c(6%), \ubc84\uc12f(5%) \ub4f1\uc774 \uc788\uc5c8\ub2e4.\u00a0<a class=\"wiki-link-external\" title=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20041403\" href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20041403\" target=\"_blank\" rel=\"noopener noreferrer\">#<\/a><\/p>\n<p>AAP\uc758 \uc57d\ub9ac\uae30\uc804\uc740 \uaf64\ub098 \ubcf5\uc7a1\ud558\uc9c0\ub9cc \uac04\ub2e8\ud788 \uc124\uba85\ud558\uba74 \ubab8\uc5d0 \uc5fc\uc99d\uc744 \uc77c\uc73c\ud0a4\ub294\u00a0<a class=\"wiki-link-internal\" title=\"\ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518\" href=\"https:\/\/namu.wiki\/w\/%ED%94%84%EB%A1%9C%EC%8A%A4%ED%83%80%EA%B8%80%EB%9E%80%EB%94%98\">\ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518<\/a>\uc744 \ud569\uc131\ud558\ub294 COX\ub97c \uc800\ud574\ud558\ub294 \uc791\uc6a9\uc744 \ud558\uc5ec \ud569\uc131\uc744 \ubc29\ud574\ud574 \ud1b5\uc99d\uc744 \ucc28\ub2e8\ud558\ub294 \uc6d0\ub9ac\uc778\ub370 \uacfc\ub7c9 \ubcf5\uc6a9\ud574\ubd24\uc790 \ud2b9\ubcc4\ud55c \ud6a8\uacfc\uac00 \ub098\ud0c0\ub098\uc9c0\ub294 \uc54a\ub294\ub2e4. \ub2e4\ub9cc \ubd84\ud574\uc0b0\ubb3c\uc774 \ub300\ub7c9 \ubc1c\uc0dd\ud558\uba74 \uac04\uc5d0 \ub3c5\uc131\uc744 \ubbf8\uce58\ub294 \uac83\uc740 \uc0ac\uc2e4\uc774\ub2e4. \uadf8\ub7f0\ub370 \ub300\ubd80\ubd84\uc758 \uacbd\uc6b0 \uac04\uc5d0 \uc190\uc0c1\uc774 \ubc1c\uc0dd\ud558\uae34 \ud558\ub294\ub370 \uc774 \uacbd\uc6b0\uc5d0\ub294 \uc77c\ubd80 \uac04\uc138\ud3ec\uac00 \uc190\uc0c1\ub418\ub354\ub77c\ub3c4 \ub098\uba38\uc9c0 \uac04\uc138\ud3ec\uac00 \ub3c5\uc131\ubb3c\uc9c8\uc744 \ubd84\ud574\ud558\uae30 \ub54c\ubb38\uc5d0 \ubcc4\ub2e4\ub978 \uc774\uc0c1\uc774 \uc5c6\ub294 \uacbd\uc6b0\uac00 \ub9ce\ub2e4.<\/p>\n<p>\ub2e4\ub9cc \uc704 \uc0ac\uac74\uacfc \uac19\uc774 \uc911\ub3c5\ub420 \uacbd\uc6b0 \uac04 \uc774\uc2dd\uc774 \ud544\uc694\ud560 \uc815\ub3c4\ub85c \uce58\uba85\uc801\uc778 \uc0c1\ud669\uc774 \uc0dd\uae38 \uc218 \uc788\uc73c\ubbc0\ub85c \uc801\ub2f9\ud55c \ubcf5\uc6a9\uc774 \ud544\uc694\ud558\ub2e4. \ubaa8\ub4e0 \uc18c\uc5fc\uc9c4\ud1b5\uc81c\ub294 \uc7a5\uae30\ubcf5\uc6a9\uacfc \uacfc\ub2e4\ubcf5\uc6a9\uc5d0 \uc7a0\uc7ac\uc801\uc778 \uc704\ud5d8\uc131\uc774 \uc788\ub2e4.<\/p>\n<\/div>\n<p class=\"wiki-heading\"><a id=\"s-7\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#toc\">7.<\/a>\u00a0\uae30\ud0c0<\/p>\n<div class=\"wiki-heading-content\">\n<ul class=\"wiki-list\">\n<li><a class=\"wiki-link-internal\" title=\"\uacf5\ub300\uac1c\uadf8\" href=\"https:\/\/namu.wiki\/w\/%EA%B3%B5%EB%8C%80%EA%B0%9C%EA%B7%B8\">\uacf5\ub300\uac1c\uadf8<\/a>\u00a0\uc911\uc5d0\ub294 \ud654\ud559\uc790\uac00 \uc57d\uad6d\uc5d0 \uac00\uc11c &#8220;\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c \uc8fc\uc138\uc694&#8221;\ub77c\uace0 \ud588\ub2e4\uac00\u00a0<a class=\"wiki-link-internal\" title=\"\uc57d\uc0ac\" href=\"https:\/\/namu.wiki\/w\/%EC%95%BD%EC%82%AC\">\uc57d\uc0ac<\/a>\uac00 &#8220;\ud0c0\uc774\ub808\ub180 \ub9d0\uc500\uc774\uc2ed\ub2c8\uae4c?&#8221; \ud558\uba74\u00a0<strong>\uc544, \uadf8\uac70\uc694. \uc815\ub9d0 \uc548 \uc678\uc6cc\uc9c0\ub294 \uc774\ub984\uc774\uc8e0?<\/strong>\ub77c\uace0 \ud55c\ub2e4\ub294 \uac8c \uc788\ub2e4(\u2026).<\/li>\n<\/ul>\n<ul class=\"wiki-list\">\n<li>\ud0c0\uc774\ub808\ub180\uc5d0\u00a0<a class=\"wiki-link-internal\" title=\"\uccad\uc0b0\uac00\ub9ac\" href=\"https:\/\/namu.wiki\/w\/%EC%B2%AD%EC%82%B0%EA%B0%80%EB%A6%AC\">\uccad\uc0b0\uac00\ub9ac<\/a>\ub97c \uc8fc\uc785\ud558\ub294 \uc0ac\uc0c1 \ucd08\uc720\uc758\u00a0<a class=\"wiki-link-internal\" title=\"\ubb3b\uc9c0\ub9c8 \ubc94\uc8c4\" href=\"https:\/\/namu.wiki\/w\/%EB%AC%BB%EC%A7%80%EB%A7%88%20%EB%B2%94%EC%A3%84\">\ubb3b\uc9c0\ub9c8 \ubc94\uc8c4<\/a>\uac00\u00a0<a class=\"wiki-link-internal\" title=\"\uc2dc\uce74\uace0\" href=\"https:\/\/namu.wiki\/w\/%EC%8B%9C%EC%B9%B4%EA%B3%A0\">\uc2dc\uce74\uace0<\/a>\uc5d0\uc11c \uc77c\uc5b4\ub09c \uc801\uc774 \uc788\ub2e4. \uc790\uc138\ud55c \ub0b4\uc6a9\uc740\u00a0<a class=\"wiki-link-internal\" title=\"\ud0c0\uc774\ub808\ub180 \ub3c5\uadf9\ubb3c \uc8fc\uc785 \uc0ac\uac74\" href=\"https:\/\/namu.wiki\/w\/%ED%83%80%EC%9D%B4%EB%A0%88%EB%86%80%20%EB%8F%85%EA%B7%B9%EB%AC%BC%20%EC%A3%BC%EC%9E%85%20%EC%82%AC%EA%B1%B4\">\ud0c0\uc774\ub808\ub180 \ub3c5\uadf9\ubb3c \uc8fc\uc785 \uc0ac\uac74<\/a>\u00a0\ucc38\uc870.<\/li>\n<\/ul>\n<ul class=\"wiki-list\">\n<li>\uace0\ub4f1\ud559\uad50 \uad50\uc721\uacfc\uc815\uc778 \uacfc\ud559\ud0d0\uad6c\uc601\uc5ed \ud654\ud5591\uc5d0\uc11c \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc758\u00a0<a class=\"wiki-link-internal\" title=\"\ubd84\uc790\uc2dd\" href=\"https:\/\/namu.wiki\/w\/%EB%B6%84%EC%9E%90%EC%8B%9D\">\ubd84\uc790\uc2dd<\/a>\uacfc \uc81c\ubc95\uc5d0 \ub300\ud574 \ub098\uc628\ub2e4. \ub2e4\ub9cc\u00a0<a class=\"wiki-link-internal\" title=\"\uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0\">\uc544\uc2a4\ud53c\ub9b0<\/a>\ucc98\ub7fc \ubcf8\uaca9\uc801\uc73c\ub85c \ubc30\uc6b0\ub294 \uac83\uc774 \uc544\ub2c8\ub77c \ud654\ud5591\uc758 \ub9c8\uc9c0\ub9c9 \ub2e8\uc6d0\uc778 \uc758\uc57d\ud488\uc5d0\uc11c \ub2e4\ub978 \uc57d\ub4e4\uacfc \uc138\ud2b8\ub85c \ub098\uc624\ub2e4 \ubcf4\ub2c8 \uc798 \uae30\uc5b5\ub418\uc9c0\ub3c4 \uc54a\uace0 \uadf8\ub2e4\uc9c0 \uc911\uc694\ud558\uac8c \uc5ec\uaca8\uc9c0\uc9c0 \uc54a\ub294 \ud3b8\uc774\ub2e4. \ud558\uc9c0\ub9cc 2010\ud559\ub144\ub3c4 \uc218\ud559\ub2a5\ub825\uc2dc\ud5d8 \ud654\ud5591 2\ubc88 \ubb38\uc81c\uc5d0 \ucd9c\uc81c\ub41c\uc801\uc774 \uc788\ub2e4.<\/li>\n<\/ul>\n<ul class=\"wiki-list\">\n<li>2013\ub144, \uad6d\ub0b4\uc5d0 \uc2dc\ud310\ub41c \uc5b4\ub9b0\uc774 \ud0c0\uc774\ub808\ub180 \ud604\ud0c1\uc561\uc5d0 \ubb38\uc81c\uac00 \ubc1c\uc0dd\ud574 \ud310\ub9e4 \uae08\uc9c0 \uc870\uce58\ub97c \ub2f9\ud588\ub2e4. \ub2e8 \uc57d \uc131\ubd84\uc5d0 \ubb38\uc81c\uac00 \uc788\uc5c8\ub358 \uac74 \uc544\ub2c8\uace0 \ubc30\ud569 \uacfc\uc815\uc5d0\uc11c \ub18d\ub3c4\uac00 \ub9de\uc9c0 \uc54a\uc558\ub358 \uac8c \uc9d5\uacc4 \uc0ac\uc720. \uc544\uc774\ub7ec\ub2c8\ud55c \uac74 \uc774 \ubb38\uc81c\ub97c \uc77c\uc73c\ud0a8 \ub2f9\uc0ac\uc790\uac00 \ud0c0\uc774\ub808\ub180\uc744 \ub9cc\ub4dc\ub294 \uc624\ub9ac\uc9c0\ub0a0 \ud68c\uc0ac\uc600\ub2e4. \uc885\uac13\uc9d1 \uae40\uce58\uac00 \uc0c1\ud55c \uc148. \uc774 \uc0ac\uac74\uc73c\ub85c \ub371\uc2dc\ubd80\ud504\ub85c\ud39c\uc774\ub780(\uc774\ubd80\ud504\ub85c\ud39c\uc758 \ubd80\uc791\uc6a9\uc744 \uac10\uc18c\uc2dc\ud0a8 \uac1c\ub7c9\ud615\uc81c\ud488.) \uc131\ubd84\uc758 \ud574\uc5f4\uc2dc\ub7fd\uc774 \ubc18\uc0ac\uc774\uc775\uc744 \uc5bb\uc5c8\ub2e4.(\ud574\ub2f9 \uc81c\ud488\ubcf4\ub2e4 \uad6d\ub0b4\uc0ac\uc5d0\uc11c \uac19\uc740 \uc131\ubd84\uc778 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc744 \uc18c\ud3ec\uc7a5\ud654\ud55c \uc81c\ud488 \ub9e4\ucd9c\uc774 \uae09\uc0c1\uc2b9\ud55c \uac83\uc73c\ub85c \uae30\uc5b5\ub418\ub294\ub370 \ud655\uc778\ubc14\ub78c)<\/li>\n<\/ul>\n<ul class=\"wiki-list\">\n<li><a class=\"wiki-link-internal\" title=\"\ud3b8\uc758\uc810\" href=\"https:\/\/namu.wiki\/w\/%ED%8E%B8%EC%9D%98%EC%A0%90\">\ud3b8\uc758\uc810<\/a>\uc5d0\uc11c\ub3c4 \ud30c\ub294 \uc0c1\ube44\uc57d\uc774\uae30\uc5d0 \ud0c0\uc774\ub808\ub180 \uc81c\ud488\uc740 24\uc2dc\uac04 \uc27d\uac8c \uad6c\ud560 \uc218 \uc788\ub2e4. \ub2e4\ub9cc, \uc720\ud1b5 \ud2b9\uc131\uc0c1 \uc57d\uad6d\ubcf4\ub2e8 \ube44\uc2f8\uba70, \ub450 \uc54c \ubd84\ub7c9\uc774 \ub4e4\uc5b4\uac00\ub294 \uc911\uac04 \ubd80\ubd84\uc774 \ube44\uc5b4 \uc788\uc5b4 \uc57d\uad6d\uc5d0\uc11c \ud30c\ub294 \uc81c\ud488\ubcf4\ub2e4 \uc6a9\ub7c9\uc774 \uc801\uc740 \uc81c\ud488\uc744 \ud310\ub9e4\ud558\ub294 \uacbd\uc6b0\ub3c4 \uc788\ub2e4. \uc5b4\uca0c\ub4e0 \uc2ec\uc57c\uc5d0 \ub3c4\uc800\ud788 \ud1b5\uc99d\uc744 \ucc38\uc744 \uc218 \uc5c6\ub294 \uacbd\uc6b0\ub098, \ub3c4\ub300\uccb4 \uc57d\uad6d\uc774 \uc5b4\ub514 \uc788\ub294\uc9c0 \ubaa8\ub97c \uacbd\uc6b0\uc5d0 \uc720\uc6a9\ud558\ub2e4.<\/li>\n<\/ul>\n<ul class=\"wiki-list\">\n<li><a class=\"wiki-link-internal\" title=\"\uace0\uc591\uc774\" href=\"https:\/\/namu.wiki\/w\/%EA%B3%A0%EC%96%91%EC%9D%B4\">\uace0\uc591\uc774<\/a>\uc5d0\uac8c\ub294 \uce58\uba85\uc801\uc778 \ub3c5\uc774\ub2e4. 500mg \ud55c\uc54c \ubd84\ub7c9\ub3c4 \uc6ec\ub9cc\ud55c \uccb4\uc911\uae4c\uc9c0\ub294 \uce58\uc0ac\ub7c9\uc5d0 \ud574\ub2f9\ud55c\ub2e4. \uadf8 \uc774\uc720\ub294 \uace0\uc591\uc774\ub294 \uac70\uc758 \uc721\uc2dd\uc744 \ud558\uae30 \ub54c\ubb38\uc5d0 \uc2dd\ubb3c\uc5d0\uc11c \ub098\uc624\ub294 \ud654\ud569\ubb3c\uc744 \ub300\uc0ac\ud558\ub294 \ub2a5\ub825 \uc911 \ud558\ub098\uc778 \uae00\ub8e8\ucfe0\ub860\uc0b0\ud3ec\ud569\uacfc\uc815\uc774 \uc9c4\ud654\ub2e8\uacc4\uc5d0\uc11c \uc18c\uc2e4\ub418\uc5c8\ub2e4. \ub530\ub77c\uc11c \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc5d0 \ub300\ud574\uc11c \ub2e4\ub978 \ub3d9\ubb3c\uc5d0 \ube44\ud574 \ub354 \ud070 \ub3c5\uc131 \ubc18\uc751<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-23\" data-original-title=\"\"><span id=\"rfn-23\" class=\"target\"><\/span>[23]<\/a>\uc744 \ub098\ud0c0\ub0b8\ub2e4.<a class=\"wiki-fn-content\" title=\"\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#fn-24\" data-original-title=\"\"><span id=\"rfn-24\" class=\"target\"><\/span>[24]<\/a>\u00a0\ube44\ub2e8 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c \ubfd0\ub9cc \uc544\ub2c8\ub77c \ubaa8\ub4e0 \uc57d\ubb3c\uc740 \ub300\uc0ac\ud558\ub294 \uc18d\ub3c4\ub098 \ud6a8\uc728\uc774 \ub3d9\ubb3c\uc5d0 \ub530\ub77c \ub2e4\ub974\ubbc0\ub85c \uc0ac\ub78c\uc5d0\uac8c \ucc98\ubc29\ud558\ub294 \uc57d\uc744 \ud568\ubd80\ub85c \ub3d9\ubb3c\uc5d0 \uba39\uc5ec\uc11c\ub294 \uc548 \ub41c\ub2e4.<\/li>\n<\/ul>\n<\/div>\n<div class=\"wiki-macro-footnote\"><span class=\"footnote-list\"><span id=\"fn-1\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-1\">[1]<\/a>\u00a0<a class=\"wiki-link-internal\" title=\"\uc560\ub4dc\ube4c\" href=\"https:\/\/namu.wiki\/w\/%EC%95%A0%EB%93%9C%EB%B9%8C\">\uc560\ub4dc\ube4c<\/a>, \ubd80\ub974\ud39c \ub4f1<\/span><span class=\"footnote-list\"><span id=\"fn-2\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-2\">[2]<\/a>\u00a0\ud604\uc7ac \uc138\uacc4\uc5d0\uc11c \uc0ac\uc6a9\ud558\ub294 3\ub300 \ucc98\ubc29 \uc9c4\ud1b5\uc81c \uc911 1\uc704\ub97c \ub2ec\ub9ac\uace0 \uc788\ub2e4. \uadf8\uc911 2\uc704\ub294\u00a0<a class=\"wiki-link-internal\" title=\"\uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0\" href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8B%B8%EC%82%B4%EB%A6%AC%EC%8B%A4%EC%82%B0\">\uc544\uc2a4\ud53c\ub9b0<\/a>, 3\uc704\ub294\u00a0<a class=\"wiki-link-internal\" title=\"\uc774\ubd80\ud504\ub85c\ud39c\" href=\"https:\/\/namu.wiki\/w\/%EC%9D%B4%EB%B6%80%ED%94%84%EB%A1%9C%ED%8E%9C\">\uc774\ubd80\ud504\ub85c\ud39c<\/a><\/span><span class=\"footnote-list\"><span id=\"fn-3\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-3\">[3]<\/a>\u00a01994\ub144<\/span><span class=\"footnote-list\"><span id=\"fn-4\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-4\">[4]<\/a>\u00a0\ud328\ub7ec\uc2dc\ud130\ubab0\uc774\ub780 \uba85\uce6d\uc774 \uc720\uba85\ud558\ub2e4\uae30 \ubcf4\ub2e8 \uadf8 \ub3d9\ub124\uc5d0\uc11c \uac00\uc7a5 \ubc94\uc6a9\uc801\uc73c\ub85c \uc4f0\uc774\ub294 \uc57d\uc804\uc778 \uc720\ub7fd\uc57d\uc804\uc5d0 \uae30\uc7ac\ub41c \uc6d0\ub8cc\uc758\uc57d\ud488\uc758 \uacf5\uc2dd\uba85\uce6d\uc774 \uadf8\uac70\ub77c\uc11c \uadf8\ub7f0 \uac70\ub2e4. \ucc38\uace0\ub85c \uc6b0\ub9ac\ub098\ub77c\uc640 \ubbf8\uad6d, \uc77c\ubcf8 \uac19\uc774 \uc790\uad6d \uc57d\uc804\uc5d0 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774\ub77c\uace0 \uae30\uc7ac\ud55c \ub098\ub77c\ub294 \uc131\ubd84\uba85\uc774\ub098 \uc81c\ud488\uba85\uc5d0 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774\ub77c\uace0 \ud45c\uae30\ud55c\ub2e4. \uc5b4\uca0c\ub4e0 \uc774\ub984\uc774 \ub2ec\ub77c\uc11c \uc11c\ub85c \ub2e4\ub978 \uc57d\uc774\ub77c\uace0 \uc624\ud574\ud560 \uc218 \uc788\uc73c\ub2c8 \uacfc\uc6a9\ud558\ub294 \uc77c\uc774 \uc5c6\ub3c4\ub85d \ud558\uc790.<\/span><span class=\"footnote-list\"><span id=\"fn-5\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-5\">[5]<\/a>\u00a0\uc544\uc138\ud2b8\uc544\ub2d0\ub9ac\ub4dc\uac00 \uc2e0\uccb4 \ub0b4 \ub300\uc0ac\uc791\uc6a9\uc744 \ud1b5\ud574 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc73c\ub85c \ubcc0\ud55c\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-6\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-6\">[6]<\/a>\u00a0\ub098\ud504\ud0c8\ub80c\uc740 \ubcf8\ub798 \ubc29\ucda9\uc81c\ub85c \uc4f0\uc774\uae30\ub3c4 \ud558\ub294\u00a0<strong>\ubc1c\uc554\ubb3c\uc9c8<\/strong>\uc774\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-7\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-7\">[7]<\/a>\u00a0\uc544\uc2a4\ud53c\ub9b0\uc758 \uac1c\ubc1c\uc0ac\uc778\u00a0<a class=\"wiki-link-internal\" title=\"\ubc14\uc774\uc5d8\" href=\"https:\/\/namu.wiki\/w\/%EB%B0%94%EC%9D%B4%EC%97%98\">\ubc14\uc774\uc5d8<\/a>\ub3c4 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc744 \uc5f0\uad6c\ud55c \uc801\uc774 \uc788\uc5c8\ub294\ub370 \uadf8\ub54c\ub294 \uadf8\ub0e5 \ubd88\uc21c\ubb3c\uc758 \uc77c\ubd80\ub85c \ucde8\uae09\ud574\uc11c \ud3d0\uae30\ud588\ub2e4. \uadf8\uac78 \ub2e4\ub978 \ud68c\uc0ac\uac00 \uac00\uc838\uac00\uc11c \uc9c4\ud1b5\uc81c 1\uc704\ub97c \uba39\uace0 \uc788\uc73c\ub2c8 \uc5bc\ub9c8\ub098 \ubc30\uac00 \uc544\ud50c\uae4c&#8230;<\/span><span class=\"footnote-list\"><span id=\"fn-8\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-8\">[8]<\/a>\u00a0\uc774\uac8c \ub2e8\uc810\ucc98\ub7fc \ubcf4\uc774\uc9c0\ub9cc \uc758\uc0ac\uc785\uc7a5\uc5d0\uc11c\ub294 \uc7a5\uc810\uc774\ub2e4. \ub450\ub4dc\ub7ec\uc9c4 \ubd80\uae30\uac00 \uc5c6\ub294 \uc0c1\ud0dc\uc5d0\uc11c \ubab8\uc0b4 \uc99d\uc0c1\uc744 \ud638\uc18c\ud558\uac70\ub098 \uc5f4\ub9cc \ub098\ub294 \uacbd\uc6b0 \ud0c0\uc774\ub808\ub180\ub9cc \uc4f0\uba74 \ub41c\ub2e4. \ub610\ud55c \ud06c\ub860\ubcd1\ub4f1\uc5d0\ub294 \uae30\ud0c0 \uc5fc\uc99d\uce58\ub8cc\ub098 \uc0ac\ub791\ub2c8 \ubc1c\uce58\uc2dc \uc18c\uc5fc\uc81c\ub97c \uc0ac\uc6a9\ud588\uc744 \ub54c \uc99d\uc0c1\uc774 \uc545\ud654\ub418\ub294 \uacbd\uc6b0\uac00 \uc788\uae30\uc5d0, \uc774\ub54c \ubbff\uace0 \ucc98\ubc29\ud560 \uc218 \uc788\ub294 \uc57d\uc774\ub77c\uace0\ub294 \ud0c0\uc774\ub808\ub180\ubfd0\uc774\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-9\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-9\">[9]<\/a>\u00a0\uc2e4\uc81c\ub85c\ub3c4 \uc6ec\ub9cc\ud558\uba74 &#8216;\ud30c\ub098\ub3cc&#8217;\uc774\ub77c\ub294 \uc0c1\ud45c\uc758 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc740 \uc5b8\uc81c\ub098 \ucc98\ubc29\ub41c\ub2e4. \ub2e4\ub9ac \ubd80\ub7ec\uc838\ub3c4 \ud30c\ub098\ub3cc, \uac10\uae30 \uac78\ub824\ub3c4 \ud30c\ub098\ub3cc, \ub450\ud1b5\uc774 \uc640\ub3c4 \ud30c\ub098\ub3cc&#8230; \ubb3c\ub860 \ud30c\ub098\ub3cc\ub9cc \ucc98\ubc29\ub418\ub294 \uac74 \uc544\ub2c8\uae30\uc5d0 \uc57d\ubc29\uc758\u00a0<a class=\"wiki-link-internal\" title=\"\uac10\ucd08\" href=\"https:\/\/namu.wiki\/w\/%EA%B0%90%EC%B4%88\">\uac10\ucd08<\/a>\ub77c\ub294 \ud45c\ud604\uc774 \uc880 \ub354 \uc815\ud655\ud560\uc9c0\ub3c4.<\/span><span class=\"footnote-list\"><span id=\"fn-10\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-10\">[10]<\/a>\u00a0\ucc38\uace0\ub85c \uc2a4\ud0c0\ubc85\uc2a4 \ucee4\ud53c \ud55c \uc794 \uae30\uc900\uc73c\ub85c \uce74\ud398\uc778 \ud568\ub7c9\uc774 100mg\uac00 \ub118\ub294\ub2e4.\u00a0<a class=\"wiki-link-internal\" title=\"\uce74\ud398\uc778\" href=\"https:\/\/namu.wiki\/w\/%EC%B9%B4%ED%8E%98%EC%9D%B8\">\uce74\ud398\uc778<\/a>\ud56d\ubaa9\uc5d0 \uc74c\ub8cc\ubcc4 \uce74\ud398\uc778 \ud568\ub7c9\uc774 \ub098\uc640\uc788\uc73c\ub2c8 \ucc38\uace0.<\/span><span class=\"footnote-list\"><span id=\"fn-11\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-11\">[11]<\/a>\u00a0\uc131\ubd84 \ud45c\uc2dc\uc5d0 &#8216;\ubb34\uc218\uce74\ud398\uc778&#8217; \uc774\ub77c\uace0 \uc368\uc838\uc788\ub294 \uacbd\uc6b0\uac00 \ub9ce\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-12\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-12\">[12]<\/a>\u00a0\ud608\uc804\uc5d0 \uc758\ud55c \ub1cc\uacbd\uc0c9\uc740 \uc608\ubc29\ud558\uc9c0\ub9cc \uadf8\uc5d0 \ub530\ub77c \ub1cc\ucd9c\ud608\ub85c \uc778\ud55c\u00a0<a class=\"wiki-link-internal\" title=\"\ub1cc\uc878\uc911\" href=\"https:\/\/namu.wiki\/w\/%EB%87%8C%EC%A1%B8%EC%A4%91\">\ub1cc\uc878\uc911<\/a>\uc758 \ub9ac\uc2a4\ud06c\uac00 \uc62c\ub77c\uac04\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-13\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-13\">[13]<\/a>\u00a0\ub2e4\ub9cc \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc740 \uc18c\uc5fc\uc791\uc6a9\uc774 \uc57d\ud55c \ub300\uc2e0 \ud574\uc5f4\uc791\uc6a9\uc774 \uac15\ud574 \uc77c\ubc18\uc801\uc73c\ub85c\u00a0<a class=\"wiki-link-internal\" title=\"NSAID\" href=\"https:\/\/namu.wiki\/w\/NSAID\">NSAID<\/a>\uc5d0\ub294 \ud3ec\ud568\uc2dc\ud0a4\uc9c0 \uc54a\ub294\ub2e4\uace0 \ud55c\ub2e4. \ud56d\ubaa9 \ucc38\uc870.<\/span><span class=\"footnote-list\"><span id=\"fn-14\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-14\">[14]<\/a>\u00a0\uc0ac\ud68c\uc801 \ubc30\uc81c(social exclusion)\uc640 \ubc30\ucc99(ostracism)\uc744 \uc5f0\uad6c\ud558\ub294 \uc720\uba85\ud55c \uc0ac\ud68c\uc2ec\ub9ac\ud559\uc790\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-15\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-15\">[15]<\/a>\u00a0\uc774\ucabd\uc740 \uc720\uc544\ub098 \uc5b4\ub9b0\uc774\uc6a9\uc73c\ub85c \uc720\uba85\ud558\ub2e4. \uc4f4\ub9db\uc744 \uacbd\uac10\uc2dc\ud0a8 \uc2dc\ub7fd\uc73c\ub85c\ub3c4 \ub098\uc624\uace0, \uc57d \uc0bc\ud0a4\ub294 \uac83\uc774 \ud798\ub4e0 \uc544\uae30\uc6a9\uc73c\ub85c \ub098\uc624\ub294\u00a0<a class=\"wiki-link-internal\" title=\"\uc88c\uc57d\" href=\"https:\/\/namu.wiki\/w\/%EC%A2%8C%EC%95%BD\">\uc88c\uc57d<\/a>\ub3c4 \uc788\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-16\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-16\">[16]<\/a>\u00a0<a class=\"wiki-link-internal\" title=\"\uad70\ub300\" href=\"https:\/\/namu.wiki\/w\/%EA%B5%B0%EB%8C%80\">\uad70\ub300<\/a>\u00a0\uc758\ubb34\uc2e4\uc5d0\uc11c \uc8fc\ub85c \ubcfc \uc218 \uc788\ub2e4. \uc758\ubb34\ubcd1\uc5d0\uac8c \ud0c0\uc774\ub808\ub180 \uad6c\uac78\uc744 \ud558\uba74 \ud68d\ub4dd \uac00\ub2a5.<\/span><span class=\"footnote-list\"><span id=\"fn-17\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-17\">[17]<\/a>\u00a0\uc57d\uad6d\uc774\ub098 \ud3b8\uc758\uc810\uc5d0\uc11c \uc77c\ubc18\uc801\uc73c\ub85c \uad6c\uc785 \uac00\ub2a5\ud55c \uc81c\ud488\uc740 \ub300\uccb4\ub85c 1\uc815 650mg\uc774\ub2c8 \ucc38\uace0\ud558\uc790.<\/span><span class=\"footnote-list\"><span id=\"fn-18\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-18\">[18]<\/a>\u00a02018\ub144 8\uc6d4 3\uc77c \uc2dd\ud488\uc758\uc57d\ud488\uc548\uc804\ucc98 \uacf5\uace0 \uc81c 2018-334\ud638\ub85c \uc758\uc57d\ud488 \ud45c\uc900\uc81c\uc870\uae30\uc900 \uc77c\ubd80\uac1c\uc815\uace0\uc2dc\uc548 \ud589\uc815\uc608\uace0\uac00 \ubc1c\ud45c\ub418\uc5c8\uc73c\ub098 \ud558\ub8e8 \ucd5c\ub300 \ud5c8\uc6a9\uce58\ub294 4,000mg\uc73c\ub85c \ubcc0\ud654\uac00 \uc5c6\ub2e4. [http:\/\/www.mfds.go.kr\/brd\/m_209\/view.do?seq=42940|#<\/span><span class=\"footnote-list\"><span id=\"fn-19\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-19\">[19]<\/a>\u00a0\uc18c\uc8fc 3\uc794 \ub610\ub294 \ub9e5\uc8fc 3\uc794\uc744 \ub9d0\ud55c\ub2e4. \ub2f9\uc5f0\ud55c \uc598\uae30\uc9c0\ub9cc \ub9e5\uc8fc\uc794 3\uc794\uc740 \uc21c\uc218 \ub9e5\uc8fc\ub9cc\uc744 \ub530\ub978 \ub9e5\uc8fc\uc794\uc744 \ub9d0\ud558\ub294 \uac70\ub2e4. \uc18c\ub9e5\uc774\ub098 \ud3ed\ud0c4\uc8fc 3\uc794\uc744 \ub9d0\ud558\ub294 \uac8c \uc544\ub2c8\ub2e4. \ub367\ubd99\uc774\uc790\uba74 \uc18c\uc8fc 3\uc794\uacfc \ub9e5\uc8fc 3\uc794\uc740 \uc54c\ucf5c \uc591\uc774 \uac19\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-20\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-20\">[20]<\/a>\u00a0\uad6c\uc785\uc774 \uc26c\uc6cc\uc11c \uac80\uc0c9\ub9cc \ud574\ubd10\ub3c4 \uc790\uc0b4\ubd80\ud130 \ud559\uad50 \ub561\ub561\uc774(\u2026)\uae4c\uc9c0 \uc5ec\ub7ec \uc0ac\ub78c\uc774 \uacfc\ub3c4\ud558\uac8c \uc12d\ucde8\ud558\uc9c0\ub9cc \uc704\uc7a5\uc774 \ub4a4\uc9d1\uc5b4\uc9c0\ub294 \uace0\ud1b5\uc5d0 \ub300\ubd80\ubd84\uc774 \uc2a4\uc2a4\ub85c \ubcd1\uc6d0\uc5d0 \uac04\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-21\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-21\">[21]<\/a>\u00a0\ud0c0\uc774\ub808\ub180\uc774\ub098 \uac8c\ubcf4\ub9b0\ub4e4\uc744 \ub300\ub7c9\uc73c\ub85c \uba39\uace0 \ubc84\ud2f0\ub2e4 \ubcd1\uc6d0\uc73c\ub85c \uac00\uba74 \ub300\ubd80\ubd84\uc740 \uc0b4\uc544\uc11c \ud1f4\uc6d0. \ubab8\uc774 \ub9dd\uac00\uc9c0\ub294 \uac74 \ub458\uc9f8 \uce58\ub354\ub77c\ub3c4 \uc77c\ub2e8 \uc798 \uc8fd\uc9c0\ub294 \uc54a\ub294\ub2e4. \uc57d\uc774 \uc704\uc7a5\uc5d0\uc11c \ud761\uc218\ub418\ub294 \ub370 \uac78\ub9ac\ub294 \uc2dc\uac04\ub3c4 \uc788\uac70\ub2c8\uc640 \uacfc\ub2e4\uc12d\ucde8\ud574 \uc7a5\uae4c\uc9c0 \uc548 \ub0b4\ub824 \uac00\ub294 \uacbd\uc6b0\ub3c4 \uc788\uace0, \ub108\ubb34 \uace0\ud1b5\uc2a4\ub7ec\uc6cc\uc11c 119\ub97c \ubd80\ub974\uae30 \ub54c\ubb38. \uc2e4\uc81c\ub85c \ubbf8\uc131\ub144\uc790\uac00 \uc8fd\uc5b4\ubc84\ub9ac\uaca0\ub2e4\uba70\u00a0<strong>\uac8c\ubcf4\ub9b0 400\uc54c\uc744 \ubbf9\uc11c\uae30\uc5d0 \uac08\uc544<\/strong>\uba39\uace0 \uc751\uae09\uc2e4\uc5d0 \uc2e4\ub824\uc640 \uc785\uc6d0\ud588\uc73c\ub098 \uc0b4\uc544\uc11c \ud1f4\uc6d0\ud55c \uacbd\uc6b0\ub3c4 \uc788\ub2e4.<\/span><span class=\"footnote-list\"><span id=\"fn-22\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-22\">[22]<\/a>\u00a0\uc544\uc9c1 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc774 \uc0dd\uc2dd\ud65c\ub3d9\uc5d0 \uc9c1\uc811\uc801\uc778 \uc601\ud5a5\uc744 \uc900\ub2e4\ub294 \uc99d\uac70\ub294 \uc5c6\ub2e4. \ub2e4\ub9cc \ub0a8\ud3b8\uc758 \uc18c\ubcc0 \uc911 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c \uc218\uce58\uac00 \ub192\uc740 \ubd80\ubd80\ub294 \uc784\uc2e0\uc5d0 \uc2dc\uac04\uc774 \uc624\ub798 \uac78\ub9b0\ub2e4\ub294 \uc5f0\uad6c\uacb0\uacfc\ub97c \ubc1c\ud45c\ud55c \uac78\u00a0<del>\uad6d\ub0b4\uc5d0\uc11c<\/del>\uae30\uc0ac\ud654 \ud558\uba74\uc11c\u00a0<a class=\"wiki-link-internal\" title=\"\uac00\uc9dc \ub274\uc2a4\" href=\"https:\/\/namu.wiki\/w\/%EA%B0%80%EC%A7%9C%20%EB%89%B4%EC%8A%A4\">\uc758\ubbf8\uac00 \ub2e4\ub974\uac8c \ubc1b\uc544\ub4e4\uc774\uac8c\ub054 \uc368\uc838\uc11c \uadf8\ub807\ub2e4.<\/a><\/span><span class=\"footnote-list\"><span id=\"fn-23\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-23\">[23]<\/a>\u00a0\uc2ec\uac01\ud55c \uc6a9\ud608\uc131 \ube48\ud608, \uadf8\ub85c\uc778\ud55c \ubb34\uae30\ub825\uac10, \uc800\uc0b0\uc18c\uc99d, \ud669\ub2ec \ub4f1<\/span><span class=\"footnote-list\"><span id=\"fn-24\" class=\"target\"><\/span><a href=\"https:\/\/namu.wiki\/w\/%EC%95%84%EC%84%B8%ED%8A%B8%EC%95%84%EB%AF%B8%EB%85%B8%ED%8E%9C#rfn-24\">[24]<\/a>\u00a0\uc544\uc2a4\ud53c\ub9b0\uc774\ub098 \uba5c\ub85d\uc2dc\uce84 \uac19\uc740 \ub2e4\ub978 \uc9c4\ud1b5\uc81c\ub3c4 \ub9c8\ucc2c\uac00\uc9c0\uc774\ub2e4.<\/span><\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>http:\/\/www.kmpnews.co.kr\/news\/articleView.html?idxno=28170<\/p>\n<p>&nbsp;<\/p>\n<h3>NSAIDs\uc758 \uc791\uc6a9\uae30\uc804\uacfc \uc774\uc0c1\ubc18\uc751<\/h3>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><strong>COX-1\u00b7COX-2 \uc5b5\uc81c \ud1b5\ud574 \ud1b5\uc99d\u00b7\uc5fc\uc99d \uc644\ud654<br \/>\n\uc704\uc7a5\uad00\u00b7\uc2e0\uc7a5\u00b7\uc2ec\ud608\uad00 \uc774\uc0c1\ubc18\uc751 \uc8fc\uc758\ud574\uc57c<\/strong><\/p>\n<p>\ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\uc131 \uc18c\uc5fc\uc9c4\ud1b5\uc81c(Nonsteroidal anti-inflammatory drugs, \uc774\ud558 NSAIDs)\ub294 \uc77c\ubc18\uc801\uc73c\ub85c \ud1b5\uc99d\uacfc \uc5fc\uc99d\uc774 \uc788\ub294 \uae09\uc131 \ub610\ub294 \ub9cc\uc131 \uc9c8\ud658\uc5d0 \uc0ac\uc6a9\ub41c\ub2e4. NSAIDs\ub294 \ud1b5\uc99d\uc744 \uc904\uc774\uace0, \uc99d\uac00\ub41c \uccb4\uc628\uc744 \ub0ae\ucd94\uba70, \uace0\uc6a9\ub7c9\uc5d0\uc11c\ub294 \uc5fc\uc99d\uc744 \uc904\uc5ec\uc900\ub2e4. NSAIDs\ub294 \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518(prostaglandin)\uc758 \uc0dd\ud569\uc131\uc5d0 \uad00\uc5ec\ud558\ub294 \uc0ac\uc774\ud074\ub85c\uc625\uc2dc\uac8c\ub098\uc81c(cyclooxygenase, \uc774\ud558 COX)\ub97c \ucc28\ub2e8\ud558\uc5ec \uadf8 \uc791\uc6a9\uc744 \ubc1c\ud604\ud558\ub294 \uc57d\ubb3c\uc774\ub2e4. \uc774\uc0c1\ubc18\uc751(side effect)\uc73c\ub85c\ub294 \uc704\uc7a5, \uc2ec\ud608\uad00, \uc2e0\uc7a5 \ub4f1\uc5d0\uc11c \ub098\ud0c0\ub09c\ub2e4.<\/p>\n<p>\uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c(acetaminophen)\uc740 \ud56d\uc5fc\uc99d \uc791\uc6a9\uc774 \uac70\uc758 \uc5c6\uae30 \ub54c\ubb38\uc5d0 \uc77c\ubc18\uc801\uc73c\ub85c NSAIDs\ub85c \uac04\uc8fc\ub418\uc9c0 \uc54a\ub294\ub2e4. \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c\uc740 \uc8fc\ub85c \uc911\ucd94 \uc2e0\uacbd\uacc4\uc758 COX-2\ub97c \ucc28\ub2e8\ud568\uc73c\ub85c\uc368 \ud1b5\uc99d\uc744 \uc904\uc774\ub294 \uc5ed\ud560\uc744 \ud558\uc9c0\ub9cc \uc2e0\uccb4\uc758 \ub2e4\ub978 \ubd80\uc704\uc5d0\ub294 \ud06c\uac8c \uc791\uc6a9\ud558\uc9c0 \uc54a\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n<p><strong>1. NSAIDs\uc758 \uc791\uc6a9\uae30\uc804<\/strong><br \/>\nNSAIDs\uc758 \uc8fc\uc694 \uc791\uc6a9\uc740 COX-1 \ubc0f COX-2 \uc5b5\uc81c\ub97c \ud1b5\ud574 \uc544\ub77c\ud0a4\ub3c8\uc0b0(arachidonic acid)\uc73c\ub85c\ubd80\ud130 \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518 \ud569\uc131\uc744 \ucc28\ub2e8\ud558\uc5ec \ud1b5\uc99d\uacfc \uc5fc\uc99d\uc744 \uc644\ud654\uc2dc\ud0a8\ub2e4. NSAIDs\uc758 \ub300\ud45c \uc57d\ubb3c\uc778 \uc544\uc2a4\ud53c\ub9b0\uc740 COX\ub97c \ube44\uac00\uc5ed\uc801\uc73c\ub85c \uc5b5\uc81c\ud558\ub294 \ubc18\uba74 \ub2e4\ub978 NSAIDs\ub294 \uc544\ub77c\ud0a4\ub3c8\uc0b0\uacfc \uac00\uc5ed\uc801 \uacbd\uc7c1\uc744 \ud1b5\ud574\uc11c COX\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud55c\ub2e4. \ub610 COX-1, 2\uc758 \uad6c\uc870\uc801 \ucc28\uc774\ub294 COX-2\uc5d0\ub9cc \uc120\ud0dd\uc801\uc73c\ub85c \uc791\uc6a9\ud558\ub294 NSAIDs\uac00 \uac1c\ubc1c\ub418\uc5c8\ub2e4.<\/p>\n<p><strong>1) \uacf5\uc720\uacb0\ud569\uc744 \ud1b5\ud55c COX\uc758 \uc5b5\uc81c: \uc544\uc2a4\ud53c\ub9b0<\/strong><br \/>\n\uc544\uc2a4\ud53c\ub9b0(acyetylsalicylic acid)\uc740 COX\uc5d0 \uc874\uc7ac\ud558\ub294 serine\uc794\uae30\ub97c \uc544\uc138\ud2f8\ud654(acetylation)\ud558\uc5ec\uc11c \ud6a8\uc18c\uc758 \ud65c\uc131\uc744 \uc5b5\uc81c\ud55c\ub2e4(\uc9c0\ub09c \ud638 cyclooxygenae\uc640 \uc544\uc2a4\ud53c\ub9b0 \ucc38\uace0).<\/p>\n<table border=\"0\" width=\"500\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td align=\"center\"><img decoding=\"async\" src=\"http:\/\/www.kmpnews.co.kr\/news\/photo\/201708\/28170_19649_1118.jpg\" border=\"1\" \/><\/td>\n<\/tr>\n<tr>\n<td id=\"font_imgdown_19649\" class=\"view_r_caption\">\u25b2 \uadf8\ub9bc 1. \uc544\uc2a4\ud53c\ub9b0\uc758 \uc791\uc6a9\uae30\uc804<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\uc544\uc2a4\ud53c\ub9b0\uc740 \u2018\uadf8\ub9bc1\u2019\uacfc \uac19\uc774 COX\uc758 \uad6c\uc870\ub97c \ubcc0\ud654(serine\uc758 acetylation)\uc2dc\ud0b4\uc73c\ub85c\uc368 COX\uc758 \ud65c\uc131\uc744 \ube44\uac00\uc5ed\uc801\uc73c\ub85c \uc5b5\uc81c\ud55c\ub2e4. \uc544\uc2a4\ud53c\ub9b0\uc5d0 \uc758\ud55c COX\uc758 \uad6c\uc870 \ubcc0\ud654\ub294 \uc544\ub77c\ud0a4\ub3c8\uc0b0\uc774 \ub300\uc0ac\ub418\ub294 \uac83\uc744 \ubc29\ud574\ud558\ub294 \uc785\uccb4 \uc7a5\uc560\ub97c \uc77c\uc73c\ud0a8\ub2e4. \uc544\uc2a4\ud53c\ub9b0\uc740 COX-1, 2 \ud6a8\uc18c \ubaa8\ub450\uc5d0 \ub3d9\uc77c\ud55c \uae30\uc804\uc73c\ub85c \uc791\ub3d9\ud55c\ub2e4.<\/p>\n<p>\uc800\uc6a9\ub7c9\uc758 \uc544\uc2a4\ud53c\ub9b0\uc740 COX-1\uc744 \uc120\ud0dd\uc801\uc73c\ub85c \uc5b5\uc81c\ud55c\ub2e4. \uc544\uc2a4\ud53c\ub9b0\uc774 \ud608\uc18c\ud310(platelet) COX-1 \ud65c\uc131\uc5d0 \ubbf8\uce58\ub294 \ud6a8\uacfc\ub294 \ud608\uc18c\ud310\uc758 \uc218\uba85 \ub3d9\uc548 \uc601\uad6c\uc801\uc774\ub2e4. \ud608\uc18c\ud310\uc740 DNA\uac00 \uc5c6\uc5b4\uc11c \uc0c8\ub85c\uc6b4 \ud6a8\uc18c\ub97c \ud569\uc131\ud560 \uc218 \uc5c6\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n<p>\uace0\uc6a9\ub7c9\uc758 \uc544\uc2a4\ud53c\ub9b0\uc740 \ub450 \uac1c\uc758 COX\ub97c \ubaa8\ub450 \uc5b5\uc81c\ud558\uc5ec \uc9c4\ud1b5, \ud574\uc5f4, \ud56d\uc5fc\uc99d \ud6a8\uacfc\ub97c \ub098\ud0c0\ub0b8\ub2e4.<\/p>\n<p><strong>2) \uc544\ub77c\ud0a4\ub3c8\uc0b0\uacfc \uac00\uc5ed\uc801 \uacbd\uc7c1\uc744 \ud1b5\ud55c COX\uc758 \uc5b5\uc81c: \uc544\uc2a4\ud53c\ub9b0\uc744 \uc81c\uc678\ud55c NSAIDs<\/strong><br \/>\n\uc544\uc2a4\ud53c\ub9b0\uc744 \uc81c\uc678\ud55c NSAIDs\ub294 COX\uc758 \ud65c\uc131\ubd80\uc704\uc5d0 \uac00\uc5ed\uc801 \uacb0\ud569(\uc544\uc2a4\ud53c\ub9b0\uacfc \ub2ec\ub9ac \ube44\uacf5\uc720 \uacb0\ud569, \uadf8\ub9bc2 \ucc38\uace0)\uc744 \ud574\uc11c \uc544\ub77c\ud0a4\ub3c8\uc0b0\uc774 \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518\uc73c\ub85c\uc758 \uc804\ud658\uc744 \uc5b5\uc81c\ud55c\ub2e4.<\/p>\n<table border=\"0\" width=\"497\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td align=\"center\"><img decoding=\"async\" src=\"http:\/\/www.kmpnews.co.kr\/news\/photo\/201708\/28170_19655_1120.jpg\" border=\"1\" \/><\/td>\n<\/tr>\n<tr>\n<td id=\"font_imgdown_19655\" class=\"view_r_caption\">\u25b2 \uadf8\ub9bc 2. NSAIDs(\uc774\ubd80\ud504\ub85c\ud39c)\uc758 \uc791\uc6a9\uae30\uc804<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\ubaa8\ub4e0 NSAIDs\ub294 COX-1\uacfc COX-2\ub97c \ub2e4\uc591\ud558\uac8c \uc5b5\uc81c\ud558\uba70, \uc5b5\uc81c\uc758 \uae30\uc804\uc740 \uc138 \ubc94\uc8fc\ub85c \ubd84\ub958\ub41c\ub2e4.<\/p>\n<p><strong>&#8211;\u00a0category 1:<\/strong>\u00a0COX-1\uacfc COX-2\uc5d0 \uc2e0\uc18d\ud558\uace0 \uacbd\uc7c1\uc801 \uac00\uc5ed \uacb0\ud569(\uc608,ibuprofen, piroxicam, mefenamic acid)<br \/>\n<strong>&#8211;\u00a0category 2:<\/strong>\u00a0COX-1\uacfc COX-2\uc5d0 \uc2e0\uc18d\ud558\uace0 \ub0ae\uc740 \uce5c\ud654\uc131 \uac00\uc5ed \uacb0\ud569\uc744 \ud55c \ud6c4\uc5d0, \uc2dc\uac04 \uc758\uc874\uc801\uc73c\ub85c \ub192\uc740 \uce5c\ud654\uc131 \ub290\ub9b0 \uac00\uc5ed \uacb0\ud569(\uc608, diclofenac, flurbiprofen, indomethacin)<br \/>\n<strong>&#8211; category 3:<\/strong>\u00a0COX-1\uacfc COX-2\uc5d0 \ube60\ub978 \uac00\uc5ed \uacb0\ud569 \ud6c4\uc5d0 \uacf5\uc720\uacb0\ud569\uc5d0 \uc758\ud55c \ud6a8\uc18c\uc758 \ubcc0\ud654(\uc608, \uc544\uc2a4\ud53c\ub9b0)<\/p>\n<p>\uc774\ubd80\ud504\ub85c\ud39c(ibuprofen)\uacfc \uac19\uc740 \uc57d\ubb3c\uc740 \uacbd\uc7c1\uc801\uc73c\ub85c \uc544\ub77c\ud0a4\ub3c8\uc0b0 \uacb0\ud569\uc744 \uc5b5\uc81c\ud558\uace0 COX \ud65c\uc131 \ubd80\uc704\ub85c\ubd80\ud130 \ube60\ub974\uac8c \ud574\ub9ac\ub41c\ub2e4. \uc774\uc640 \ub300\uc870\uc801\uc73c\ub85c \ud50c\ub8e8\ube44\ud504\ub85c\ud39c(flurbiprofen)\uc740 \ucc98\uc74c\uc5d0\ub294 \uc544\ub77c\ud0a4\ub3c8\uc0b0\uacfc \uacbd\uc7c1\ud558\uae30 \uc5b4\ub835\uc9c0\ub9cc \uc2dc\uac04\uc5d0 \ub530\ub77c COX\uc5d0 \ub2e8\ub2e8\ud788 \uacb0\ud569\ud55c\ub2e4. \uc774\ubd80\ud504\ub85c\ud39c\uacfc \ud50c\ub8e8\ube44\ud504\ub85c\ud39c \ubaa8\ub450 \ud65c\uc131 \uc0ac\uc774\ud2b8\uc5d0 \uc720\uc0ac\ud55c \ud615\ud0dc\ub97c \ucde8\ud558\uba70 category 1\uacfc2 NSAIDs \uc0ac\uc774\uc758 \uc57d\ub3d9\ud559\uc801 \ucc28\uc774\ub294 Arg120, Tyr355 \ubc0f Glu524\uc5d0 \uc758\ud574 \uc0dd\uc131\ub41c COX \ucc44\ub110\uc744 \ud1b5\ud574 \uc811\uadfc\ud558\ub294 \uc18d\ub3c4\uc640 \ud6a8\uc728\uc774\ub77c\ub294 \uac83\uc774 \uc81c\uc548\ub418\uc5c8\ub2e4.<\/p>\n<p><strong>3) COX-2 \uc120\ud0dd\uc801 \uc800\ud574\uc81c<\/strong><br \/>\nCOX-1\uc740 \ub300\ubd80\ubd84\uc758 \uc870\uc9c1\uc5d0 \ubc1c\ud604\ub418\uba70 \uc815\uc0c1\uc801\uc778 \uc138\ud3ec \uc791\uc6a9\uc744 \uc720\uc9c0\ud558\ub294\ub370 \uad00\uc5ec\ud568\uc73c\ub85c\uc368 \uc704\uc7a5 \uc810\ub9c9\uc758 \ubcf4\ud638, \ud608\uad00\uc758 \ud56d\uc0c1\uc131, \ud608\uc18c\ud310\uc758 \uc751\uc9d1, \uc2e0\uc7a5 \uae30\ub2a5 \uc720\uc9c0\uc640 \uac19\uc740 \ud56d\uc0c1\uc131 \uc720\uc9c0 \uae30\ub2a5\uc744 \ub2f4\ub2f9\ud55c\ub2e4. \ubc18\uba74 COX-2\ub294 \ud3c9\uc0c1\uc2dc\uc5d0\ub294 \uac70\uc758 \uac80\ucd9c\ub418\uc9c0 \uc54a\ub2e4\uac00 \uc720\ud574\ud55c \uc790\uadf9\uc5d0 \ub300\ud55c \uc5fc\uc99d\ubc18\uc751\uc73c\ub85c \uad6d\uc18c\uc801\uc73c\ub85c \ube60\ub974\uac8c \uc720\ub3c4\ub41c\ub2e4. COX-2 \uc120\ud0dd\uc801 \uc800\ud574\uc81c(\uc774\ud558 coxib)\ub294 \ube44\uc120\ud0dd\uc801 NSAIDs\uc5d0 \uc758\ud574\uc11c \ub098\ud0c0\ub098\ub294 \uc704\uc7a5 \ucd9c\ud608\uc758 \uc720\ud574\ubc18\uc751\uc744 \ud53c\ud558\uae30 \uc704\ud574\uc11c \uace0\uc548\ub418\uc5c8\ub2e4.<\/p>\n<p>coxib\uc758 \uc791\uc6a9\uc740 COX-1\uacfc COX-2\ud6a8\uc18c\uc758 \uad6c\uc870\uc801 \ucc28\uc774\ub85c \uc778\ud574\uc11c \uac00\ub2a5\ud558\ub2e4(\uc9c0\ub09c \ud638 cyclooxygenae\uc640 \uc544\uc2a4\ud53c\ub9b0\uacfc \uadf8\ub9bc3 \ucc38\uace0).<\/p>\n<table border=\"0\" width=\"500\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td align=\"center\"><img decoding=\"async\" src=\"http:\/\/www.kmpnews.co.kr\/news\/photo\/201708\/28170_19656_130.jpg\" border=\"1\" \/><\/td>\n<\/tr>\n<tr>\n<td id=\"font_imgdown_19656\" class=\"view_r_caption\">\u25b2 \uadf8\ub9bc 3. COX-2 \uc120\ud0dd\uc801 \uc800\ud574\uc81c\uc758 \uc791\uc6a9\uacfc coxib\uc758 \uc885\ub958<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>coxib\uac00 \uac00\uc9c0\uace0 \uc788\ub294 sulfonamide \uadf8\ub8f9\uc774 COX-2 \ud6a8\uc18c\uc758 \uc544\ub974\uae30\ub2cc(Arg513)\uc5d0 \uacb0\ud569\ud558\uba74\uc11c \uc544\ub77c\ud0a4\ub3c8\uc0b0\uacfc \uacbd\uc7c1\ud558\uc5ec \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518\uc744 \uc5b5\uc81c\ud558\ub294 \uc791\uc6a9\uc744 \ud55c\ub2e4. \ubc18\uba74 COX-1 \ud6a8\uc18c\uc5d0\ub294 coxib\uac00 \uad6c\uc870\uc801\uc73c\ub85c \uacb0\ud569\uc744 \ud560 \uc218 \uc5c6\ub2e4. \ub530\ub77c\uc11c coxib\ub294 COX-1 \ud6a8\uc18c\uc758 \ud65c\uc131\uc740 \uc720\uc9c0(\uc704\uc7a5\uad00 \ubcf4\ud638)\uac00 \ub418\uace0, COX-2 \ud6a8\uc18c\ub9cc \uc120\ud0dd\uc801\uc73c\ub85c \uc5b5\uc81c\ud558\uc5ec\uc11c \uc704\uc7a5\uc7a5\ud574 \uc5c6\uc774 \ud1b5\uc99d\uc744 \uc5b5\uc81c\ud55c\ub2e4.<\/p>\n<p><strong>2. NSAIDs\uc758 \uc774\uc0c1\ubc18\uc751<\/strong><\/p>\n<div><strong>&#8211;\u00a0\uc2ec\ud608\uad00\uacc4 \uc704\ud5d8:\u00a0<\/strong>\uc774 \uc57d\uc740 \uc911\ub300\ud55c \uc2ec\ud608\uad00\uacc4 \ud608\uc804 \ubc18\uc751, \uc2ec\uadfc\uacbd\uc0c9\uc99d \ubc0f \ub1cc\uc878\uc911\uc758 \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\uc73c\uba70, \uc774\ub294 \uce58\uba85\uc801\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \ubaa8\ub4e0 \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\uc131 \uc18c\uc5fc\uc9c4\ud1b5\uc81c \uc57d\ubb3c\uc5d0 \uc758\ud574 \uc720\uc0ac\ud55c \uc704\ud5d8\uc774 \ubc1c\uc0dd\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n<strong>&#8211;\u00a0\uc704\uc7a5\uad00\uacc4 \uc704\ud5d8:\u00a0<\/strong>\uc774 \uc57d\uc744 \ud3ec\ud568\ud55c \ube44\uc2a4\ud14c\ub85c\uc774\ub4dc\uc131 \uc18c\uc5fc\uc9c4\ud1b5\uc81c \uc57d\ubb3c\uc740 \uc704 \ub610\ub294 \uc7a5\uad00\uc758 \ucd9c\ud608, \uada4\uc591 \ubc0f \ucc9c\uacf5\uc744 \ud3ec\ud568\ud55c \uc911\ub300\ud55c \uc704\uc7a5\uad00\uacc4 \uc774\uc0c1\ubc18\uc751\uc758 \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\uc73c\uba70 \uc774\ub294 \uce58\uba85\uc801\uc77c \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc774\uc0c1\ubc18\uc751\uc740 \ud22c\uc5ec \uae30\uac04 \ub3d9\uc548\uc5d0 \uacbd\uace0 \uc99d\uc0c1 \uc5c6\uc774 \ubc1c\uc0dd\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uace0\ub839\uc790\ub294 \uc911\ub300\ud55c \uc704\uc7a5\uad00\uacc4 \uc774\uc0c1\ubc18\uc751\uc758 \uc704\ud5d8\uc774 \ub354 \ud074 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<br \/>\n<strong>[\ud45c 1] \ube44\uc2a4\ud14c\ub85c\uc774\uc131 \uc18c\uc5fc\uc9c4\ud1b5\uc81c(NSAIDs)\uc758 \uacbd\uace0 \ubb38\uad6c \uc694\uc57d<\/strong><\/div>\n<p>NSAIDs\ub294 COX \ud6a8\uc18c\ub97c \uc5b5\uc81c\ud568\uc73c\ub85c\uc368 \uc791\uc6a9\uc744 \ud55c\ub2e4. \uc774\uac83\uc740 \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518 \uc0dd\ud569\uc131\uc744 \uac10\uc18c\uc2dc\ud0b4\uc73c\ub85c\uc368 \uc720\uc775\ud55c \ud6a8\uacfc \ubc0f \uc6d0\uce58 \uc54a\ub294 \ud6a8\uacfc\ub97c \ubaa8\ub450 \ub098\ud0c0\ub098\uac8c \ud55c\ub2e4. \u2018\ud45c1\u2019\uc5d0 \uc801\ud600\uc788\ub294 \uacbd\uace0 \ubb38\uad6c\ub294 NSAIDs \ubc0f celecoxib \ubaa8\ub450\uc5d0 \ud45c\uae30 \ub418\uc5b4\uc788\ub2e4.<br \/>\nNSAIDs\uc758 \uc774\uc0c1\ubc18\uc751\uc740 \ud06c\uac8c \uc704\uc7a5\uad00, \uc2e0\uc7a5 \ubc0f \uc2ec\ud608\uad00 3\uac00\uc9c0\ub85c \ub098\ub204\uc5b4 \uc0dd\uac01\ud560 \uc218 \uc788\ub2e4.<\/p>\n<table border=\"0\" width=\"500\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td align=\"center\"><img decoding=\"async\" src=\"http:\/\/www.kmpnews.co.kr\/news\/photo\/201708\/28170_19650_1119.jpg\" border=\"1\" \/><\/td>\n<\/tr>\n<tr>\n<td id=\"font_imgdown_19650\" class=\"view_r_caption\">\u25b2 \uadf8\ub9bc 4 .NSAIDs\uc758 \uc774\uc0c1\ubc18\uc751<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>1) \uc704\uc7a5\uad00 \uc774\uc0c1\ubc18\uc751<\/strong><br \/>\nCOX-1 \ud6a8\uc18c\uc5d0 \uc758\ud574\uc11c \uc0dd\uc131\ub418\ub294 PGE2\uc640 PGI2\ub294 \uc704\uc7a5\uc5d0\uc11c \uc815\uc0c1 \ud608\ub958 \uc870\uc808\ubfd0\ub9cc \uc544\ub2c8\ub77c \uc911\ud0c4\uc0b0\uc5fc\uacfc \uc810\uc561 \uc0dd\uc131\uc744 \uc870\uc808\ud558\ub294\ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4. \uc774\uac83\uc740 \uc704\uc0b0\uc5d0 \uc758\ud55c \uc704\ubcbd\uc744 \uac10\uc2f8\uc11c \uc138\ud3ec\ub97c \ubcf4\ud638\ud558\ub294\ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4. \ub530\ub77c\uc11c, \uc544\uc2a4\ud53c\ub9b0 \ubc0f \ube44\uc120\ud0dd\uc801 NSAIDs\ub294 COX-1\uc744 \ucc28\ub2e8\ud558\uc5ec \uc18c\ud654\uc131 \uada4\uc591\uc758 \ubc1c\uc0dd\uc774 \uc99d\uac00\ud560 \uac83\uc73c\ub85c \uc608\uc0c1\ub41c\ub2e4. \uc18c\ud654\uc131 \uada4\uc591\uc758 \uc815\ub3c4\ub294 \ub2e4\uc591\ud558\uba70, \uae09\uc131 \ucd9c\ud608\uc740 \ube44\uad50\uc801 \ud754\ud558\ub2e4.<\/p>\n<p><strong>2) \uc2e0\uc7a5\uc5d0\uc11c\uc758 \uc774\uc0c1\ubc18\uc751<\/strong><br \/>\n\uc2e0\uc7a5\uc5d0\uc11c \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518\uc740 \uc8fc\ub85c \ud608\uad00\ud655\uc7a5\uc81c\ub85c \uae30\ub2a5\ud55c\ub2e4. \uac74\uac15\ud55c \uac1c\uc778\uc758 \uacbd\uc6b0 \uc2e0\uc7a5 \uad00\ub958(renal perfusion)\ub294 \ube44\uad50\uc801 \uc81c\ud55c\uc801\uc774\ub2e4. \ud558\uc9c0\ub9cc \ub098\uc774\uac00 \ub9ce\uac70\ub098, \uc2ec\ubd80\uc804, \uc2e0\ubd80\uc804\uc774 \uc788\uc73c\uba74 \uc2e0\uc7a5 \ud608\uad00 \uc218\ucd95\uc774 \uc77c\uc5b4\ub098\uace0, \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518 \ud569\uc131\uc774 \uc99d\uac00\ud55c\ub2e4. \uc2e0\uc7a5 \uae30\ub2a5\uc774 \uc190\uc0c1\ub41c \uc774\ub7ec\ud55c \uc870\uac74(\uace0\ub839, \uc2ec\ubd80\uc804, \uc2e0\ubd80\uc804)\uc5d0\uc11c \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518 \uc0dd\uc131\uc740 \uc2e0\uc7a5 \ud608\ub958\ub97c \ubcf4\uc874\ud558\uace0, \uc2e0\uc0ac\uad6c\uccb4 \ub3d9\ub9e5\uc758 \uc800\ud56d\uc744 \uac10\uc18c\uc2dc\ud0b4\uc73c\ub85c\uc368 \uc0ac\uad6c\uccb4 \uc5ec\uacfc\uc728(glomerular filtration rate, GFR)\uc744 \ubcf4\uc874\ud55c\ub2e4. \uc774 \uc0c1\ud669\uc5d0\uc11c NSAIDs\ub97c \uc77c\uc2dc\uc801\uc73c\ub85c \uc0ac\uc6a9\ud558\ub354\ub77c\ub3c4 \uc0ac\uad6c\uccb4\ub97c \ud1b5\ud55c \ud608\ub958\ub97c \uac10\uc18c\uc2dc\ud0a4\uace0 \uae09\uc131 \uc2e0\uc7a5 \uc190\uc0c1\uc758 \uc704\ud5d8\uc744 \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\ub2e4.<\/p>\n<table border=\"0\" width=\"500\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td align=\"center\"><img decoding=\"async\" src=\"http:\/\/www.kmpnews.co.kr\/news\/photo\/201708\/28170_19651_1119.jpg\" border=\"1\" \/><\/td>\n<\/tr>\n<tr>\n<td id=\"font_imgdown_19651\" class=\"view_r_caption\">\u25b2 \uadf8\ub9bc 5. \uc2e0\uc7a5\uc5d0\uc11c \ud608\ub958\uc870\uc808\uacfc \uc0ac\uad6c\uccb4 \uc5ec\uacfcAng\u2161: angiotensin \u2161, GFR: \uc0ac\uad6c\uccb4 \uc5ec\uacfc\uc728<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\uc0ac\uad6c\uccb4 \uc5ec\uacfc\uc728\uc740 \uc0ac\uad6c\uccb4\ub0b4 \uc555\ub825 \uad6c\ubc30\uac00 \uc815\uc0c1 \uc218\uc900\uc744 \uc720\uc9c0\ub420 \ub54c \ucd5c\uc801\uc758 \uc0c1\ud0dc\uac00 \ub41c\ub2e4. \uc800\ud608\uc555, \uccb4\uc561 \uac10\uc18c(\ucd9c\ud608, \uacfc\ub3c4\ud55c \uc774\ub1e8), \uc2ec\ubc15\ucd9c\ub825 \uac10\uc18c\ub098 \ud3d0\uc0c9(\uc2e0\uc7a5 \ub3d9\ub9e5 \ud611\ucc29)\uc740 \uc0ac\uad6c\uccb4 \uc555\ub825\uc774 \uac10\uc18c\ud558\uace0 \uc2e0\uae30\ub2a5\uc5d0 \uc190\uc0c1\uc744 \uac00\uc838\uc628\ub2e4. \uc815\uc0c1\uc801\uc778 \uc2e0\uc7a5 \uae30\ub2a5\uc774 \uc190\uc0c1\ub418\uba74 \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518 \ud569\uc131\uc774 \uc99d\uac00\ub418\uc5b4 \uc0ac\uad6c\uccb4\uc5d0 \ub4e4\uc5b4\uac00\ub294 \ud608\uad00\uc744 \ud655\uc7a5\ud558\uc5ec \uc2e0\uc7a5\uad00\ub958\ub97c \uc720\uc9c0\ud558\ub294\ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud55c\ub2e4. \ub610, ACE \uc5b5\uc81c\uc81c(angiotensin converting enzyme inhibitor)\ub294 \uc548\uc9c0\uc624\ud150\uc2e0 \u2161(angiotensin \u2161)\uc758 \ud6a8\uacfc\ub97c \uac10\uc18c\uc2dc\ucf1c \uc0ac\uad6c\uccb4\uc5d0\uc11c \ud608\uc561\uc774 \ube68\ub9ac \ube60\uc838\ub098\uac00\uac8c \ub418\uace0, \uacb0\uacfc\uc801\uc73c\ub85c \uc2e0\uc7a5 \uad00\ub958\uac00 \uac10\uc18c\ud558\uba74\uc11c \uc2e0\ubd80\uc804\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\ub2e4.<\/p>\n<p><strong>3) \uc2ec\ud608\uad00 \uc774\uc0c1\ubc18\uc751<\/strong><br \/>\nNSAIDs\uc758 \uc2ec\ud608\uad00 \uc704\ud5d8\uc758 \uc99d\uac00\ub294 \uc5ec\ub7ec \uac00\uc9c0 \uae30\uc804\uacfc \uad00\ub828\uc774 \uc788\ub294 \uac83\uc73c\ub85c \ubcf4\uc778\ub2e4.<\/p>\n<p><strong>&#8211;\u00a0NSAIDs \uc720\ubc1c \uace0\ud608\uc555<\/strong><br \/>\n\ubaa8\ub4e0 NSAIDs\ub294 \uc815\uc0c1 \ud608\uc555 \ubc0f \uace0\ud608\uc555 \ud658\uc790\uc5d0\uc11c \uc218\ucd95\uae30\/\uc774\uc644\uae30 \ud608\uc555\uc744 \ud3c9\uade03\/2mmHg \uc99d\uac00\uc2dc\ud0ac \uc218 \uc788\ub2e4. \uace0\ud608\uc555 \ud6a8\uacfc\ub294 \uc6a9\ub7c9\uc758\uc874\uc801\uc774\uba70 \uc2e0\uc7a5\uc5d0\uc11c COX-2 \uc5b5\uc81c\ub85c \uc778\ud55c Na\ubc30\uc124 \uac10\uc18c \ubc0f \ud608\uc561\uc758 \ubd80\ud53c \uc99d\uac00\ub85c \uc778\ud55c \uac83\uc774\ub2e4.<\/p>\n<p><strong>&#8211;\u00a0\uc2e0\uc7a5 \uc9c8\ud658\uc758 \uc704\ud5d8 \uc99d\uac00<\/strong><br \/>\n\uc2e0\uc7a5 \uc9c8\ud658\uc774 \uc788\ub294 \ud658\uc790\uc758 \uacbd\uc6b0 \uc2e0\uc7a5 \uae30\ub2a5\uc740 \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518 \uc0dd\uc131\uc5d0 \ub530\ub77c \ub2ec\ub77c\uc9c4\ub2e4. \uc774 \ud658\uc790\ub4e4\uc5d0\uac8c NSAIDs\ub97c \uc0ac\uc6a9\ud558\uba74 \uc2e0\uc7a5 \uae30\ub2a5\uc758 \uae09\uc131 \uc545\ud654 \uc704\ud5d8\uc774 \uc99d\uac00\ud558\uba70 \uc0ac\uad6c\uccb4 \uc5ec\uacfc\uc728 \uac10\uc18c, Na \ucd95\uc801, \ubd80\uc885, \uace0\uce7c\ub968\ud608\uc99d \ubc0f \uace0\ud608\uc555\uc774 \ubc1c\uc0dd\ud560 \uc218 \uc788\ub2e4.<\/p>\n<p><strong>&#8211;\u00a0\ud608\uc555\uac15\ud558\uc81c\uc758 \ud6a8\uacfc \uac10\uc18c<\/strong><br \/>\nNSAIDs\ub294 \uce7c\uc298\ucc44\ub110\ucc28\ub2e8\uc81c\ub97c \uc81c\uc678\ud55c \ubaa8\ub4e0 \ud608\uc555\uac15\ud558\uc81c\uc758 \ud6a8\uacfc\ub97c \uac10\uc18c\uc2dc\ud0a4\ub294 \uac83\uc73c\ub85c \uad00\ucc30\ub418\uc5c8\ub2e4. \ub2e8, \uc800\uc6a9\ub7c9\uc758 \uc544\uc2a4\ud53c\ub9b0(75mg)\uc740 \ud608\uc555\uc744 \uc0c1\uc2b9\uc2dc\ud0a4\uc9c0 \uc54a\uc73c\uba70, \ud608\uc555\uac15\ud558\uc81c\uc758 \ud6a8\uacfc\ub97c \ubc29\ud574\ud558\uc9c0 \uc54a\ub294\ub2e4.<\/p>\n<p><strong>&#8211; NSAIDs\ub294 \uc544\uc2a4\ud53c\ub9b0\uc758 \ud56d\ud608\uc18c\ud310 \ud6a8\uacfc\uc5d0 \uc601\ud5a5<\/strong><br \/>\nNSAIDs\uc758 \ud22c\uc5ec\ub294 COX-1\uc5d0\ub3c4 \ud6a8\uacfc\ub97c \ubcf4\uc774\uba70 \uc544\uc2a4\ud53c\ub9b0\uacfc \uacbd\uc7c1\uad00\uacc4\ub97c \uac00\uc9c0\uace0 \uc788\ub2e4.<\/p>\n<table border=\"0\" width=\"500\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td align=\"center\"><img decoding=\"async\" src=\"http:\/\/www.kmpnews.co.kr\/news\/photo\/201708\/28170_19652_1119.jpg\" border=\"1\" \/><\/td>\n<\/tr>\n<tr>\n<td id=\"font_imgdown_19652\" class=\"view_r_caption\">\u25b2 \uadf8\ub9bc 6. \uc774\ubd80\ud504\ub85c\ud39c\uacfc \uc544\uc2a4\ud53c\ub9b0\uc758 \uc0c1\ud638\uc791\uc6a9<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\u2018\uadf8\ub9bc6\u2019\uc5d0\uc11c \ubcf4\ub294 \uac83\ucc98\ub7fc \uc544\uc2a4\ud53c\ub9b0 \uc12d\ucde8 2\uc2dc\uac04 \uc804\uc5d0 \uc774\ubd80\ud504\ub85c\ud39c\uc758 \uc12d\ucde8\ub294 \ud2b8\ub86c\ubcf5\uc0b0 A2(tromboxane A2)\uc758 \uc0dd\uc131\uc744 \uc5b5\uc81c\ud558\ub294 \uc544\uc2a4\ud53c\ub9b0\uc758 \uae30\ub2a5\uc744 \ubc29\ud574(\uc785\uccb4\uc801 \ubc29\ud574)\ud558\uc9c0\ub9cc \uc544\uc2a4\ud53c\ub9b0 2\uc2dc\uac04 \ud6c4\uc5d0 \uc774\ubd80\ud504\ub85c\ud39c\uc744 \ubcf5\uc6a9\ud558\uba74 \uc544\uc2a4\ud53c\ub9b0\uc758 \ud56d\ud608\uc18c\ud310 \ud6a8\uacfc\uac00 \uc720\uc9c0\ub41c\ub2e4.<\/p>\n<p>2004\ub144 9\uc6d4 30\uc77c \ubc14\uc774\uc625\uc2a4\u24e1(rofecoxib)\ub294 APPROVe(adenomatous Polyp Prevention on Vioxx) \uc2dc\ud5d8\uc5d0\uc11c \ub098\uc628 \ubcf4\uace0\uc11c\ub97c \ud1a0\ub300\ub85c \uc804 \uc138\uacc4 \uc2dc\uc7a5\uc5d0\uc11c \ucca0\uc218\ub418\uc5c8\ub2e4. \ubc14\uc774\uc625\uc2a4\uc640 \uc704\uc57d\uacfc\uc758 \ube44\uad50\ud588\uc744 \ub54c \uc2ec\uadfc\uacbd\uc0c9, \ub1cc\uc878\uc911 \ub4f1 \uc2ec\ud608\uad00\uacc4 \uc9c8\ud658 \ubc1c\ubcd1 \uc704\ud5d8\uc131\uc740 18\uac1c\uc6d4\uc758 \uce58\ub8cc\uae30\uac04 \uc774\ud6c4\ubd80\ud130 \ub098\ud0c0\ub098\uae30 \uc2dc\uc791\ud588\ub2e4. \uc544\uc9c1 \uc815\ud655\ud55c \uc774\uc720\ub294 \uc54c\ub824\uc9c0\uc9c0 \uc54a\uc558\uc9c0\ub9cc COX-1\uacfc COX-2\uc5d0 \uc758\ud574 \uc0dd\uc131\ub418\ub294 \ud2b8\ub86c\ubcf5\uc0b0\uacfc \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518\uc758 \ubd88\uade0\ud615 \uac00\uc124 \ub4f1\uc774 \uc788\ub2e4.<\/p>\n<table border=\"0\" width=\"500\" cellspacing=\"0\" cellpadding=\"0\" align=\"center\">\n<tbody>\n<tr>\n<td align=\"center\"><img decoding=\"async\" src=\"http:\/\/www.kmpnews.co.kr\/news\/photo\/201708\/28170_19653_1119.jpg\" border=\"1\" \/><\/td>\n<\/tr>\n<tr>\n<td id=\"font_imgdown_19653\" class=\"view_r_caption\">\u25b2 \uadf8\ub9bc 7. COX-2 \uc120\ud0dd\uc801 \uc800\ud574\uc81c\uc640 \uc2ec\ud608\uad00 \uc704\ud5d8, \ud2b8\ub86c\ubcf5\uc0b0\/\ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518 \ubd88\uade0\ud615 \uac00\uc124<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>\ud2b8\ub86c\ubcf5\uc0b0(TXA2)\uc740 \ud608\uc18c\ud310\uc758 COX-1\uc5d0 \uc758\ud574\uc11c \uc0dd\uc131\uc774 \ub418\uace0, \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518(PGI2)\uc740 \ud608\uad00 \ub0b4\ud53c\uc138\ud3ec\uc758 COX-2\uc5d0 \uc758\ud574\uc11c \uc0dd\uc131\uc774 \ub41c\ub2e4. PGI2\ub294 \ud608\uad00 \ud655\uc7a5 \ubc0f \ud608\uc18c\ud310 \ud65c\uc131\ud654\ub97c \uc5b5\uc81c\ud558\uace0, TXA2\ub294 \ud608\uad00 \uc218\ucd95 \ubc0f \ud608\uc18c\ud310 \uc751\uc9d1\uc744 \uc99d\uac00\uc2dc\ud0a8\ub2e4. PGI2\uc640 TXA2\uc758 \uade0\ud615 \uc7a1\ud78c \ud6a8\uacfc \uc77c \ub54c, \uc815\uc0c1\uc801\uc778 \ud608\uad00 \ud56d\uc0c1\uc131\uc774 \uc720\uc9c0\ub41c\ub2e4.<br \/>\nCOX-2 \uc120\ud0dd\uc801 \uc800\ud574\uc81c\ub85c \uc778\ud574\uc11c TXA2 \ud615\uc131(\ubc18\ub300\ub85c PGI2\ub294 \uac10\uc18c)\uc73c\ub85c \uade0\ud615\uc774 \uae30\uc6b8\uba74\uc11c \ud608\uad00 \uc218\ucd95\uacfc \ud608\uc18c\ud310 \uc751\uc9d1\uc774 \uc77c\uc5b4\ub098\uae30 \uc27d\uace0, \uc2ec\uadfc \uacbd\uc0c9 \ubc0f \ub1cc\uc878\uc911\uacfc \uac19\uc740 \uc2ec\ud608\uad00 \uc9c8\ud658 \uc704\ud5d8\uc774 \uc99d\uac00\ud55c\ub2e4.<\/p>\n<p>\ud604\uc7ac \uc6b0\ub9ac\ub098\ub77c\uc5d0\uc11c \uc2dc\ud310\ub418\uace0 \uc788\ub294 COX-2 \uc120\ud0dd\uc801 \uc800\ud574\uc81c\ub294 celecoxib(\uc384\ub808\ube0c\ub809\uc2a4<sup>\u24e1<\/sup>), etoricoxib(\uc54c\ucf55\uc2dc\uc544<sup>\u24e1<\/sup>), polmacoxib(\uc544\uc140\ub809\uc2a4<sup>\u24e1<\/sup>)\uac00 \uc788\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>http:\/\/www.sisapress.com\/journal\/article\/99345<\/p>\n<p>&nbsp;<\/p>\n<h2 class=\"tit\">\uac00\uc7a5 \ub180\ub77c\uc6b4 \uc57d \uc544\uc2a4\ud53c\ub9b0\uc758 \ube44\ubc00<\/h2>\n<h6 class=\"desc\">\ub1cc\uc878\uc911 \uc608\ubc29 \ub4f1 \ud0c1\uc6d4\ud55c \ud6a8\ub2a5 \uc18d\uc18d \ubc1d\ud600\uc838 \ucdcc\uc7a5\uc554\u00b7\uc720\uc0b0\u00b7\uc704\uc7a5 \ucd9c\ud608 \ubd80\ub97c \uc218\ub3c4<\/h6>\n<p>&nbsp;<\/p>\n<p>\ud398\ub2d0\ud504\ub85c\ud310\uc62c\uc544\ubbfc(PPA) \uc131\ubd84\uc774 \ud568\uc720\ub41c \uac10\uae30\uc57d \ud0d3\uc77c\uae4c. \uc758\uc57d\ud488\uc5d0 \ub300\ud55c \uad6d\ubbfc \ubd88\uc548\uc774 \ub192\uc544\uac00\uace0 \uc788\ub2e4. \ucd5c\uadfc \u2018\uc758\uc57d\ud488 \ubd80\uc791\uc6a9\u2019\uc5d0 \ub300\ud55c \ud589\uc815 \ub2f9\uad6d\uc758 \ubaa8\ub2c8\ud130\ub9c1\uc5d0 \ubb38\uc81c\uac00 \uc788\ub2e4\ub294 \uc9c0\uc801\uae4c\uc9c0 \ub098\uc624\uba74\uc11c \ubd88\uc2e0\uc740 \ub354\uc6b1 \uc9d9\uc5b4\uac00\ub294 \uc591\uc0c1\uc774\ub2e4. \uadf8\ub7ec\ub098 \uc57d\uc744 \uc9c0\ub098\uce58\uac8c \uc758\uc2ec\ud560 \ud544\uc694\ub294 \uc5c6\uc744 \uac83 \uac19\ub2e4. \uc138\uc0c1\uc5d0\ub294 \uc704\uc57d(\u50de\u85e5)\ubcf4\ub2e4 \uc601\uc57d(\uf9b3\u85e5) \uc18c\ub9ac\ub97c \ub4e3\ub294 \uc57d\uc774 \ub354 \ub9ce\uc73c\ub2c8 \ub9d0\uc774\ub2e4.<\/p>\n<p>\uac00\uc815 \uc0c1\ube44\uc57d \uac00\uc6b4\ub370 \ud558\ub098\uc778 \uc544\uc2a4\ud53c\ub9b0\ub3c4 \uadf8 \uc911 \ud558\ub098. \uc131\uc778\ub4e4\uc5d0\uac8c \uc544\uc2a4\ud53c\ub9b0\uc740 \u2018\ucd94\uc5b5\uc758 \uc54c\uc57d\u2019\uc73c\ub85c \ubd88\ub9b4 \ub9cc\ud558\ub2e4. \uc5b4\ub9b4 \ub54c \uc5f4\uc774 \uc788\uac70\ub098 \ub450\ud1b5\uc774 \uc788\uc73c\uba74 \ub298 \uc544\uc2a4\ud53c\ub9b0\uc744 \uba39\uc5c8\ub2e4. \uc544\uc2a4\ud53c\ub9b0\uc758 \uc57d\ud6a8\ub294 \ube60\ub974\uace0 \uc2e0\uae30\ud588\ub2e4. \uba39\uace0 \uba87 \uc2dc\uac04 \uc9c0\ub098\uba74 \uc5f4\uacfc \ud1b5\uc99d\uc774 \uac10\ucabd\uac19\uc774 \uc0ac\ub77c\uc84c\ub2e4. \uc5bc\ub9c8\ub098 \uc2e0\ud1b5\ud55c\uc9c0 \uc0ac\ub78c\ub4e4\uc740 \u2018\ub9cc\ubcd1 \ud1b5\uce58\uc57d\u2019\uc774\ub77c\uace0 \ubd80\ub974\uae30\ub3c4 \ud588\ub2e4.<\/p>\n<p>1969\ub144 \ub2ec \ucc29\ub959 \uc6b0\uc8fc\uc120 \uc544\ud3f4\ub85c 11\ud638 \uc6b0\uc8fc\uc778\ub4e4\uc774 \uc6b0\uc8fc \uc5ec\ud589\uc5d0 \uac00\uc838\uac00\uba74\uc11c \uc544\uc2a4\ud53c\ub9b0\uc758 \uc778\uae30\ub294 \ub354\uc6b1 \uce58\uc19f\uc558\ub2e4. \uadf8\ub807\ub2e4\uace0 \ud574\ub3c4 \ub2f9\uc2dc \uc544\uc2a4\ud53c\ub9b0 \uc55e\uc5d0 \ubd99\uc740 \u2018\uc601\uc57d\u2019\uc774\ub098 \u2018\ub9cc\ubcd1 \ud1b5\uce58\uc57d\u2019 \uac19\uc740 \ub9d0\uc740 \uc880 \uacfc\uc7a5\ub41c \uac10\uc774 \uc5c6\uc9c0 \uc54a\uc558\ub2e4. \uae30\uaecf\ud574\uc57c \uc5f4\uacfc \ud1b5\uc99d\uc744 \uac10\uc18c\uc2dc\ud0a4\ub294 \ub2a5\ub825\ubc16\uc5d0 \uc5c6\uc5c8\uae30 \ub54c\ubb38\uc774\ub2e4(\ubb3c\ub860 \uadf8\uac83\ub3c4 \u2018\uae30\uc801\u2019\uc5d0 \uac00\uae4c\uc6b4 \uc77c\uc774\uc5c8\ub2e4). \uadf8\ub85c\ubd80\ud130 30\uc5ec \ub144\uc774 \ud750\ub978 \uc9c0\uae08 \uc0c1\ud669\uc740 \ud06c\uac8c \ubcc0\ud588\ub2e4. \uc5c4\uccad\ub09c \uc544\uc2a4\ud53c\ub9b0\uc758 \ud6a8\ub2a5\uc774 \uc18d\uc18d \ubc1d\ud600\uc9c0\uba74\uc11c \ubbf8\uad6d\uc5d0\uc11c\uc870\ucc28 \u2018\uac00\uc7a5 \ub180\ub77c\uc6b4 \uc57d\u2019\uc73c\ub85c \ubd88\ub9ac\ub294 \uac83\uc774\ub2e4. \uc544\uc2a4\ud53c\ub9b0\uc758 \ubb34\uc5c7\uc774 \ub180\ub78d\ub2e4\ub294 \uc18c\ub9ac\ub97c \ub4e3\uac8c \ub9cc\ub4dc\ub294 \uac83\uc77c\uae4c.<\/p>\n<p>\uc544\uc2a4\ud53c\ub9b0\uc740 19\uc138\uae30 \ub9d0 \ub3c5\uc77c\uc758 \ud654\ud559\uc790 \ud3a0\ub9ad\uc2a4 \ud638\ud504\ub9cc\uc774 \ub958\uba38\ud2f0\uc998\uc73c\ub85c \uace0\uc0dd\ud558\ub294 \uc544\ubc84\uc9c0\ub97c \uc704\ud574 \ub9cc\ub4e0 \uc57d\uc774\ub2e4. \uadf8 \ub4a4 \uc544\uc2a4\ud53c\ub9b0\uc740 \u2018\uc9c4\ud654\u2019\ub97c \uac70\ub4ed\ud588\uace0, \uadf8 \ub355\uc5d0 \uc218\ub9ce\uc740 \uc0ac\ub78c\uc774 \ub9cc\uc131 \ud1b5\uc99d\uc73c\ub85c\ubd80\ud130 \ubc97\uc5b4\ub0ac\ub2e4. \ub450\ud1b5\uc744 \uc553\ub294 \uc0ac\ub78c\uc740 \ub3d9\uc758\ud558\uc9c0 \uc54a\uaca0\uc9c0\ub9cc, \uc0ac\uc2e4 \ud1b5\uc99d\uc740 \uc0dd\uc874\uc5d0 \uaf2d \ud544\uc694\ud55c \uc694\uc18c\ub2e4. \uac74\uac15 \ubb38\uc81c\ub098 \uc9c8\ubcd1\uc5d0 \ub300\ud574 \uc8fc\uc758\ub97c \ud658\uae30\ud558\uace0, \ubc18\uc0ac \uc791\uc6a9\uc744 \ud1b5\ud574 \ub354 \ud070 \uc704\ud5d8\uc73c\ub85c\ubd80\ud130 \uc778\uccb4\ub97c \ubcf4\ud638\ud574\uc8fc\uae30 \ub54c\ubb38\uc774\ub2e4(\uc720\uc804\uc801 \uacb0\ud568\uc5d0 \uc758\ud574 \ud1b5\uc99d\uc744 \ubabb \ub290\ub07c\ub294 \uc0ac\ub78c\uc774 \uc77c\ucc0d \uc8fd\ub294 \uac83\uc740 \uadf8\uac19\uc740 \uae30\ub2a5\uc774 \uc81c\ub300\ub85c \uc791\ub3d9\ud558\uc9c0 \ubabb\ud574\uc11c\uc774\ub2e4).<br \/>\n\uc544\uc2a4\ud53c\ub9b0\uc774 \ud1b5\uc99d\uc744 \ubc18\uac10\uc2dc\ud0a4\ub294 \uc6d0\ub9ac\ub294 \uac04\ub2e8\ud558\ub2e4. \uc544\uc2a4\ud53c\ub9b0\uc5d0 \ud568\uc720\ub41c \uc544\uc138\ud2f8\uc0b4\ub9ac\uc2e4\uc0b0\uc774 \uc0c1\ud574\uc640 \uac10\uc5fc\uc5d0 \uc758\ud55c \ubc18\uc751\uc744 \uc870\uc808\ud558\ub294 \ucc9c\uc5f0 \ud638\ub974\ubaac(\ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518)\uc758 \uc0dd\ud569\uc131\uc744 \uc5b5\uc81c\ud558\ub294 \uac83\uc774\ub2e4. \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518\uc740 \ud1b5\uc99d \uc804\ub2ec\uc744 \ub3d5\uace0, \ud608\uc18c\ud310\uc5d0 \uc2e0\ud638\ub97c \ubcf4\ub0b4 \ud608\ubcd1(\u8840\u9920:\ud53c\uac00 \uc751\uace0\ub418\uc5b4 \uc0dd\uae30\ub294 \ub369\uc5b4\ub9ac)\uc774 \uc0dd\uc131\ub418\ub3c4\ub85d \ud558\uba70, \uba74\uc5ed \uccb4\uacc4\uc758 \uad6d\uc9c0 \ubc18\uc751\uc778 \uc5fc\uc99d\uc744 \uc77c\uc73c\ud0a8\ub2e4. \ub530\ub77c\uc11c \uc774 \ubb3c\uc9c8\uc758 \ubc1c\ud604\uc774 \uc5b5\uc81c\ub418\uba74 \uadf8\ub9cc\ud07c \ud1b5\uc99d\uacfc \uc5f4\uc774 \uc904\uc5b4\ub4e4 \uc218\ubc16\uc5d0 \uc5c6\ub2e4.<\/p>\n<p>\uc544\uc2a4\ud53c\ub9b0\uc758 \u2018\ub2a5\ub825\u2019\uc740 \uac70\uae30\uc5d0\uc11c \uadf8\uce58\uc9c0 \uc54a\ub294\ub2e4. 1970\ub144\ub300 \ucd08, \uc758\ud559\uc790\ub4e4\uc740 \uc544\uc2a4\ud53c\ub9b0\uc774 \ud608\uc18c\ud310\uc758 \uc751\uc9d1\uc744 \ucc28\ub2e8\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1d\ud600\ub0c8\ub2e4. \uadf8\uac83\uc740 \uace7 \uc544\uc2a4\ud53c\ub9b0\uc774 \uc2ec\uc7a5\ubcd1\uc5d0\ub3c4 \ud6a8\uacfc\uac00 \uc788\uc74c\uc744 \ub73b\ud55c\ub2e4. 1980\ub144\ub300 \ucd08, \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(FDA)\uc740 \uc5ec\ub7ec \uc5f0\uad6c \uc790\ub8cc\ub97c \ud1a0\ub300\ub85c \uc544\uc2a4\ud53c\ub9b0\uc744 \ub1cc\uacbd\uc0c9(\ub1cc\uc878\uc911)\uacfc \uc2ec\uc7a5\ub9c8\ube44 \uc7ac\ubc1c \ubc29\uc9c0 \uc57d\uc73c\ub85c \uc2b9\uc778\ud588\ub2e4.<\/p>\n<p>1989\ub144\uc5d0 \ubbf8\uad6d \ud558\ubc84\ub4dc \uc758\ub300\uc5d0\uc11c \uc880\ub354 \uc9c4\uc804\ub41c \uc5f0\uad6c\uac00 \ud3bc\uccd0\uc84c\ub2e4. \ucc30\uc2a4 \ud5e8\ucf04\uc2a4 \uad50\uc218(\uc608\ubc29\uc758\ud559) \ud300\uc740 \uac74\uac15\ud55c \ub0a8\uc131 \uc758\uc0ac 2\ub9cc2\ucc9c\uba85\uc744 \ub450 \uadf8\ub8f9\uc73c\ub85c \ub098\ub208 \ub4a4 5\ub144 \ub3d9\uc548 \ud55c \uadf8\ub8f9\uc5d0\ub294 \uc774\ud2c0\uc5d0 \ud55c \ubc88\uc529 \uc544\uc2a4\ud53c\ub9b0 325mg\uc744, \ub2e4\ub978 \ud55c \uadf8\ub8f9\uc5d0\ub294 \uc704\uc57d\uc744 \ud22c\uc5ec\ud588\ub2e4. \uadf8 \uacb0\uacfc \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud55c \uadf8\ub8f9\uc758 \uc2ec\uadfc\uacbd\uc0c9\uc99d \ubc1c\ubcd1\ub960\uc774 44%\ub098 \ub0ae\uc558\ub2e4.<\/p>\n<p>\uc774\ud6c4 \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d\uc740 \uc544\uc2a4\ud53c\ub9b0\uc744 \uc544\uc608 \uc2ec\uc7a5\ub9c8\ube44 \uce58\ub8cc\uc57d\uc73c\ub85c \uc2b9\uc778\ud588\uace0, \ubbf8\uad6d\uc778\uc740 \uadf8\ub54c\ubd80\ud130 \uc544\uc2a4\ud53c\ub9b0\uc744 \ub2e4\ub978 \ubaa9\uc801\uc73c\ub85c \ubcf5\uc6a9\ud558\uae30 \uc2dc\uc791\ud588\ub2e4. \uc989 \uc2ec\uc7a5\ub9c8\ube44 \uc7ac\ubc1c\uc744 \ubc29\uc9c0\ud558\uae30 \uc704\ud574\uc11c\uac00 \uc544\ub2c8\ub77c, \ucc98\uc74c\ubd80\ud130 \uc2ec\uc7a5\ub9c8\ube44\ub97c \uc608\ubc29\ud558\uae30 \uc704\ud574 \ub9e4\uc77c \ubcf5\uc6a9\ud558\uae30 \uc2dc\uc791\ud55c \uac83\uc774\ub2e4. 2002\ub144 \ub9d0 \ud604\uc7ac, \uadf8 \uc778\uad6c\ub294 2\ucc9c6\ubc31\ub9cc\uba85\uc73c\ub85c \ucd94\uc815\ub41c\ub2e4.<\/p>\n<p>\ub958\uc655\uc131 \uad50\uc218(\uc911\uc559\ub300 \uc758\ub300\u00b7\uc21c\ud658\uae30\ub0b4\uacfc)\ub294 \uc544\uc2a4\ud53c\ub9b0\uc774 \ud5c8\ud608\uc131 \ub1cc\uc878\uc911 \uc608\ubc29\uc5d0\ub3c4 \uc6b0\uc218\ud55c \ud6a8\ub2a5\uc774 \uc788\ub2e4\uace0 \ub9d0\ud55c\ub2e4. \ud608\uc804\uc774 \uad00\uc0c1\ub3d9\ub9e5\uc744 \ub9c9\uc73c\uba74 \uc2ec\uadfc\uacbd\uc0c9\uc774 \ubc1c\uc0dd\ud55c\ub2e4. \uadf8\ub7ec\ub098 \ud608\uc804\uc774 \ub1cc\ub3d9\ub9e5\uc774\ub098 \uacbd\ub3d9\ub9e5 \ub4f1\uc744 \ub9c9\uc73c\uba74 \ub1cc\uc758 \uc911\uc694\ud55c \ubd80\ubd84\uc774 \uc9e7\uc740 \uc2dc\uac04 \uc548\uc5d0 \uad34\uc0ac\ud558\ub294 \ub1cc\uc878\uc911\uc774 \uc77c\uc5b4\ub09c\ub2e4. \uc774 \uc9c8\ud658\uc740 \ud754\ud788 \uc2ec\ud55c \uac70\ub3d9 \uc7a5\uc560\u00b7\uc5b8\uc5b4 \uc7a5\uc560\u00b7\uc2dc\uac01 \uc7a5\uc560\ub97c \uc218\ubc18\ud558\ub294\ub370, \ub3c4\uac00 \uc9c0\ub098\uce58\uba74 \uc0ac\ub9dd\uc5d0 \uc774\ub974\uae30\ub3c4 \ud55c\ub2e4.<\/p>\n<p>\ud55c \uc790\ub8cc\uc5d0 \ub530\ub974\uba74, \ubbf8\uad6d\uc5d0\uc11c\ub9cc \ud55c \ud574\uc5d0 50\ub9cc\uba85 \ub118\uac8c \ub1cc\uc878\uc911 \ud658\uc790\uac00 \ubc1c\uc0dd\ud55c\ub2e4. \uadf8\ub9ac\uace0 \uadf8\ub4e4 \uc911 5\uba85\uc5d0 1\uba85\uaf34\ub85c \uc0ac\ub9dd\ud558\uba70, 3\uba85 \uc911 1\uba85\uaf34\ub85c \uc7a5\uc560\uc790\uac00 \ub41c\ub2e4. 2002\ub144 \u2018\ud56d\ud608\uc18c\ud310 \uc5f0\uad6c\uc778 \ud611\ud68c\u2019\ub294 &lt;\uc601\uad6d \uc758\ud559 \uc800\ub110&gt;\uc5d0 \ubc1c\ud45c\ud55c \uc5f0\uad6c \ub17c\ubb38\uc744 \ud1b5\ud574, \uc544\uc2a4\ud53c\ub9b0\uc774 \ub1cc\uc878\uc911\uacfc \uc911\ud48d\uc758 \ubc1c\ubcd1 \ud655\ub960\uc744 25%\ub098 \ub5a8\uc5b4\ub728\ub9b0\ub2e4\uace0 \uc8fc\uc7a5\ud588\ub2e4. \ub610 \ub2e4\ub978 \uc5f0\uad6c\uc9c4\uc740 \ub1cc\uc878\uc911 \uc704\ud5d8\uc5d0 \ub178\ucd9c\ub41c \uc0ac\ub78c\uc5d0\uac8c \uc544\uc2a4\ud53c\ub9b0\uc744 \uc9c0\uc18d\uc801\uc73c\ub85c \ud22c\uc57d\ud558\uba74 \ub1cc\uc878\uc911 \ubc1c\uc0dd\ub960\uc774 22%\ub098 \uac10\uc18c\ud55c\ub2e4\ub294 \uc5f0\uad6c \uacb0\uacfc\ub97c \ub0b4\ub193\uc558\ub2e4. \uc774\ub294 \ub1cc\uc878\uc911\uc5d0 \ub178\ucd9c\ub41c \ubbf8\uad6d\uc778 2\ucc9c\ub9cc \uba85(1999\ub144 \uc790\ub8cc) \uac00\uc6b4\ub370 4\ubc3150\ub9cc \uba85\uc774 \uc544\uc2a4\ud53c\ub9b0\uc758 \ub3c4\uc6c0\uc73c\ub85c \ubaa9\uc228\uc744 \uac74\uc9c8 \uc218 \uc788\uc74c\uc744 \ub73b\ud55c\ub2e4.<\/p>\n<p>\uc544\uc2a4\ud53c\ub9b0\uc740 \ub54c\ub54c\ub85c \ube44\ud589\uae30 \uc548\uc5d0\uc11c\ub3c4 \ube5b\uc744 \ubc1c\ud55c\ub2e4. \ube44\ud589\uae30\uc758 \uc881\uc740 \uc88c\uc11d\uc5d0 \uc549\uc544 \uc624\ub7ab\ub3d9\uc548 \uc5ec\ud589\ud558\ub2e4 \ubcf4\uba74 \ud608\uc804\uc774 \ubc1c\uc0dd\ud55c\ub2e4. \uc804\ubb38\uac00\ub4e4\uc740 \uc774\ub97c \u2018\uc774\ucf54\ub178\ubbf8 \ud074\ub798\uc2a4 \uc99d\ud6c4\uad70\u2019\uc774\ub77c\uace0 \ubd80\ub974\ub294\ub370, \ud56d\uacf5 \uc5ec\ud589\uc744 \uc2dc\uc791\ud558\uae30 \uba70\uce60 \uc804\ubd80\ud130 \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\uba74 \uc774\ub97c \uc608\ubc29\ud560 \uc218 \uc788\ub2e4(\ubbf8\uad6d\uc740 \ub9e4\ub144 6\ub9cc\uba85 \uc774\uc0c1\uc774 \uc774\ucf54\ub178\ubbf9 \ud074\ub798\uc2a4 \uc99d\ud6c4\uad70\uc73c\ub85c \uc0ac\ub9dd\ud558\uba70, \ud55c\uad6d\uc5d0\uc11c\ub294 1998~2002\ub144\uc5d0 27\uba85\uc774 \uc0ac\ub9dd\ud588\ub2e4).<\/p>\n<p>\uc5b4\ub514 \uadf8\ubfd0\uc778\uac00. \uc544\uc2a4\ud53c\ub9b0\uc740 \uc8fc 5\uc77c \uadfc\ubb34\ub85c \uc810\uc810 \ub298\uace0 \uc788\ub294 \uc2a4\ud0a8\uc2a4\ucfe0\ubc84\uc5d0\uac8c\ub3c4 \ub3c4\uc6c0\uc744 \uc900\ub2e4. \uadf8\ub4e4\uc774 \ud754\ud788 \uacaa\ub294 \uc7a0\uc218\ubcd1\uc744 \uc608\ubc29\ud558\ub294 \uac83\uc774\ub2e4. \uc0ac\ub78c\uc774 \ubc14\ub2e4 \uc18d\uc5d0 \ub4e4\uc5b4\uac00\uba74 \uc218\uc555 \ub54c\ubb38\uc5d0 \ub1cc\ub3d9\ub9e5 \uc0c9\uc804\uc99d\uc774 \ubc1c\uc0dd\ud55c\ub2e4. \uadf8\ub7f0\ub370 \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\uba74 \ud608\uc18c\ud310\uc774 \uc751\uc9d1\ub418\uc9c0 \uc54a\uc544 \uc0c9\uc804\uc99d\uc5d0 \uac78\ub9ac\uc9c0 \uc54a\ub294\ub2e4. \ub2f9\ub1e8\ubcd1 \ud6c4\uae30 \ud569\ubcd1\uc99d\uc744 \uc608\ubc29\ud558\ub294 \ub370\ub3c4 \uc544\uc2a4\ud53c\ub9b0\uc774 \uc4f0\uc778\ub2e4. \ub2f9\ub1e8\ubcd1\uc740 \uc2ec\uc7a5\ubcd1\uacfc \ub1cc\uc878\uc911\uc744 \uc77c\uc73c\ud0ac \uc218 \uc788\ub294 \uac00\uc7a5 \uc704\ud5d8\ud55c \uc6d0\uc778 \uac00\uc6b4\ub370 \ud558\ub098\uc774\ub2e4. \ub2f9\ub1e8\ubcd1 \ud658\uc790 \uc911 50% \uc774\uc0c1\uc774 \ud6c4\uae30 \uc99d\uc0c1\uc778 \uc2ec\uadfc\uacbd\uc0c9\uc73c\ub85c \uc8fd\uace0, 12%\ub294 \ubd80\uc791\uc6a9\uc778 \ub1cc\uc878\uc911\uc73c\ub85c \uc0ac\ub9dd\ud55c\ub2e4. \ubc18\uba74 \ub2f9\ub1e8\uc5d0 \uc758\ud55c \uae09\uc131 \ud63c\uc218\ub85c \uc8fd\ub294 \ud658\uc790 \ube44\uc728\uc740 \ucc44 1%\uac00 \ub418\uc9c0 \uc54a\ub294\ub2e4. \ub530\ub77c\uc11c \ub2f9\ub1e8 \ud658\uc790\uac00 \uc544\uc2a4\ud53c\ub9b0\uc744 \uc7a5\uae30 \ubcf5\uc6a9\ud558\uba74 \uc2ec\uadfc\uacbd\uc0c9\uacfc \ub1cc\uc878\uc911 \ubc1c\ubcd1 \uac00\ub2a5\uc131\uc774 \uc904\uc5b4, \uadf8\ub9cc\ud07c \uc0ac\ub9dd \uc704\ud5d8\uc744 \uc904\uc77c \uc218 \uc788\ub2e4.<\/p>\n<p>\ud638\uc8fc\uc758 \ubcd1\ub9ac\ud559\uc790 \uac00\ube0c\ub9ac\uc5d8 \ucfe4 \ubc15\uc0ac\ub294 \uc624\ub79c \uc5f0\uad6c \ub05d\uc5d0 \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\uba74 \uacb0\uc7a5\uc554\uc5d0 \uac78\ub9b4 \ud655\ub960\uc774 \uc778\uad6c\uc758 \ud1b5\uacc4\uc801 \ud3c9\uade0\uce58\ubcf4\ub2e4 40% \ub5a8\uc5b4\uc9c4\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ud655\uc778\ud588\ub2e4. \uc608\ubc29 \uc6d0\ub9ac\ub294 \uac04\ub2e8\ud588\ub2e4. \uc885\uc591\uc758 \uc131\uc7a5\uc744 \ucd09\uc9c4\ud558\ub294 \ud504\ub85c\uc2a4\ud0c0\uae00\ub780\ub518\uc758 \uc0dd\ud569\uc131\uc744 \uc5b5\uc81c\ud574 \uc554\uc758 \ubc1c\ud604\uc744 \ub9c9\ub294 \uac83\uc774\ub2e4. \ud558\ubc84\ub4dc \uc758\ub300 \uc5d0\ub4dc\uc6cc\ub4dc \uc9c0\uc624\ubc18\ub204\uce58 \ubc15\uc0ac \ud300\uc740 \uac70\uae30\uc5d0\uc11c \ud55c \uac78\uc74c \ub354 \ub098\uc544\uac14\ub2e4. \uac74\uac15\ud55c 30~35\uc138 \ubbf8\uad6d \uac04\ud638\uc0ac 12\ub9cc2\ucc9c\uba85\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc2e4\ud5d8\uc5d0\uc11c, \uc544\uc2a4\ud53c\ub9b0\uc744 \uc7a5\uae30(\ucd5c\uc18c\ud55c 10\ub144) \ubcf5\uc6a9\ud558\uba74 \uacb0\uc7a5\uc554\uc73c\ub85c \uc778\ud55c \uc0ac\ub9dd\ub960\uc774 44% \uc774\uc0c1 \uac10\uc18c\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc54c\uc544\ub0b8 \uac83\uc774\ub2e4.<br \/>\n\uba87\uba87 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc544\uc2a4\ud53c\ub9b0\uc774 \uc804\ub9bd\uc120\uc554\u00b7\ucdcc\uc7a5\uc554\u00b7\uc2dd\ub3c4\uc554 \ub4f1\uc744 \uc608\ubc29\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ud655\uc778\ub418\uc5c8\ub2e4. \uadf8\ub7ec\ub098 \uc544\uc9c1\uae4c\uc9c0 \uc554 \uc608\ubc29\uc744 \uc704\ud574 \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud574\uc57c \ud558\ub294\uc9c0\uc5d0 \ub300\ud574\uc11c\ub294 \ub17c\ub780\uc774 \ubd84\ubd84\ud558\ub2e4. 1996\ub144 \ubbf8\uad6d\uc554\ud611\ud68c\uc758 \ub300\uaddc\ubaa8 \uc5f0\uad6c \ucc45\uc784\uc790\uc600\ub358 \ubbf8\uccbc \ud134 \ubc15\uc0ac\ub294 \uc774\ub807\uac8c \ub9d0\ud55c\ub2e4. \u201c\uc77c\ubd80 \uc88b\uc740 \uacb0\uacfc\uac00 \uc788\uc5c8\uc9c0\ub9cc, \ucd5c\uc801 \ud22c\uc5ec\ub7c9\uacfc \uc801\uc6a9 \uc99d\uc0c1 \ubc0f \ubd80\uc791\uc6a9\uc5d0 \ub300\ud55c \uc911\uc694\ud55c \uc758\ubb38\uc810\ub4e4\uc774 \ud480\ub824\uc57c \ud55c\ub2e4. \ub530\ub77c\uc11c \uc544\uc9c1\ub3c4 \ub9ce\uc740 \uc784\uc0c1 \ubc0f \ubcd1\ub9ac\ud559 \uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4.\u201d \ub9cc\uc57d \ud134 \ubc15\uc0ac \uac19\uc740 \uc758\ud559\uc790\ub4e4\uc774 \uad81\uae08\ud574 \ud558\ub294 \uc758\ubb38\uc774 \uc77c\uc2dc\uc5d0 \ud480\ub9b0\ub2e4\uba74 \uc5b4\ub5a4 \uc77c\uc774 \uc77c\uc5b4\ub0a0\uae4c. \uc544\ub9c8\ub3c4 \uc544\uc2a4\ud53c\ub9b0\uc740 \uc774 \uc138\uc0c1 \ubaa8\ub4e0 \uc57d\ud488\uc758 \u2018\uc655\uc911\uc655\u2019\uc774 \ub420 \uac83\uc774\ub2e4.<\/p>\n<p>\uc9c0\uae08\ub3c4 \uc218\ub9ce\uc740 \uc5f0\uad6c\ub97c \ud1b5\ud574 \uc544\uc2a4\ud53c\ub9b0\uc758 \uc0c8\ub85c\uc6b4 \ud6a8\ub2a5\ub4e4\uc774 \ud558\ub098\ub458 \ubc1d\ud600\uc9c0\uace0 \uc788\ub2e4. \u2018\ubd88\uc784 \uc5ec\uc131\uc774 \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\uba74 \uac00\uc784 \ud655\ub960\uc774 \ubc30\ub85c \uc99d\uac00\ud55c\ub2e4\u2019 \u2018\uc54c\uce20\ud558\uc774\uba38 \ubc1c\ubcd1 \uc704\ud5d8\uc744 \uc904\uc778\ub2e4\u2019 \u2018\ub1cc\uc885\uc591\uc778 \ub2e4\ud615\uc131\uc544\uad50\uc885(\u591a\u5f62\u6210\u82bd\u81a0\u816b)\uc744 \uc608\ubc29\ud55c\ub2e4\u2019 \u2018\uc787\ubab8 \uc9c8\ud658\uc744 \uc553\ub294 \uc0ac\ub78c\ub4e4\uc774 \uc544\uc2a4\ud53c\ub9b0\uc744 \uc18c\ub7c9 \ubcf5\uc6a9\ud558\uba74 \uce58\uc8fc\uc5fc\uc5d0 \uac78\ub9b4 \ud655\ub960\uc774 \ub0ae\uc544\uc9c4\ub2e4\u2019 \u201820~74\uc138 \uc0ac\ub78c\uc774 \uc2e4\uba85\ud558\ub294 \uac00\uc7a5 \ud070 \uc6d0\uc778\uc778 \ub2f9\ub1e8\uc131 \ub9dd\ub9c9\uc5fc \uc608\ubc29\uc5d0 \ub3c4\uc6c0\uc744 \uc900\ub2e4\u2019 \u2018\uc720\ubc29\uc554 \ubc1c\ubcd1\uc744 \ub9c9\uc544\uc900\ub2e4\u2019 \ub4f1\uc774 \ube44\uad50\uc801 \ucd5c\uadfc\uc5d0 \ubc1d\ud600\uc9c4 \ud6a8\ub2a5\ub4e4\uc774\ub2e4. \uadf8\ub7ec\ub098 \uc774\ub7f0 \u2018\uae30\uc801\u2019\ub4e4\uc740 \uc880\ub354 \uac80\uc99d\uc744 \uac70\uccd0\uc57c \uc2e0\ub8b0\ubc1b\uc744 \uc218 \uc788\ub2e4.<br \/>\n\ube5b\uc774 \uc788\uc73c\uba74 \uadf8\ub298\uc774 \uc788\ub4ef, \uc57d\uc758 \ud6a8\uacfc\uac00 \uc788\uc73c\uba74 \ubd80\uc791\uc6a9\uc774 \uc788\ub294 \ubc95. \uc774 \ubc95\uce59\uc740 \uc544\uc2a4\ud53c\ub9b0\uc5d0\ub3c4 \uc801\uc6a9\ub41c\ub2e4. \uc758\uc0ac\ub4e4\uc740 \u2018\uc5b4\ub5a4 \uc57d\uc5d0 \ubd80\uc791\uc6a9\uc774 \uc804\ud600 \uc5c6\ub2e4\uba74 \ub0b4\uc138\uc6b8 \ub9cc\ud55c \ud6a8\uacfc\ub3c4 \uc5c6\ub2e4\ub294 \uc758\ubbf8\u2019\ub77c\uace0 \ub9d0\ud55c\ub2e4. \uadf8\ub807\ub2e4. \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud55c \ub4a4\uc5d0\ub3c4 \ubd80\uc791\uc6a9\uc774 \ub098\ud0c0\ub09c\ub2e4. \uac00\uc7a5 \ud754\ud55c \ubd80\uc791\uc6a9\uc740 \uc18d\uc774 \uc4f0\ub9ac\uace0 \uc544\ud508 \uc704\uada4\uc591\uc774\ub2e4. \uc2ec\ud558\uba74 \uc704\uc7a5 \ucd9c\ud608\uc774 \uc77c\uc5b4\ub098\uae30\ub3c4 \ud55c\ub2e4. \ub610 \ub2e4\ub978 \ubd80\uc791\uc6a9\uc740 \ud56d\ud608\uc18c\ud310(\ud53c\ub97c \uad73\uc9c0 \uc54a\uac8c \ud558\ub294) \uc791\uc6a9\uc73c\ub85c \uc778\ud55c \u2018\uc9c0\ud608 \ubc29\ud574\u2019\uc774\ub2e4. \uc0dd\ub9ac\u00b7\ucd9c\uc0b0\u00b7\uc218\uc220\uc744 \uc55e\ub454 \uc0ac\ub78c\uc5d0\uac8c \uc544\uc2a4\ud53c\ub9b0 \ubcf5\uc6a9\uc744 \uae08\ud558\ub294 \uac83\ub3c4 \uadf8 \ub54c\ubb38\uc774\ub2e4.<\/p>\n<p>\ub3c5\uac10\uc774\ub098 \uc218\ub450\uc5d0 \uac78\ub9b0 16\uc138 \uc774\ud558 \uc5b4\ub9b0\uc774\uac00 \uc544\uc2a4\ud53c\ub9b0\uc744 \uba39\uc73c\uba74 \uac04\ud639 \ub77c\uc774 \uc99d\ud6c4\uad70\uc774 \ubc1c\uc0dd\ud558\uae30\ub3c4 \ud55c\ub2e4. \ub77c\uc774 \uc99d\ud6c4\uad70\uc740 \uc778\ud50c\ub8e8\uc5d4\uc790\ub098 \uc218\ub450 \ub4f1 \ubc14\uc774\ub7ec\uc2a4\uc131 \uc9c8\ud658\uc5d0 \uac78\ub9b0 \uc5b4\ub9b0\uc774\uc5d0\uac8c\ub9cc \uc77c\uc5b4\ub098\ub294 \ub4dc\ubb38 \ubcd1\uc774\ub2e4. \uae09\uc131\ub1cc\uc99d\uacfc \ud568\uaed8 \uac04\uc758 \uc9c0\ubc29\ubcc0\uc131\uc744 \uc218\ubc18\ud558\ub294 \uc9c8\ud658\uc73c\ub85c\uc11c \uc9c0\ub098\uce58\uba74 \ud658\uc790\uac00 \uc0ac\ub9dd\ud558\ub294 \uacbd\uc6b0\ub3c4 \uc788\ub2e4.<\/p>\n<p>\uc774 \uc678\uc5d0\ub3c4 \ucd5c\uadfc \ub4e4\uc5b4 \uc880\ub354 \uc5f0\uad6c\uac00 \ud544\uc694\ud55c \ubd80\uc791\uc6a9\ub4e4\uc774 \ud558\ub098 \ub458 \ubc1c\ud45c\ub418\uace0 \uc788\ub2e4. \uc9c0\ub09c 3\uc6d46\uc77c, \ubbf8\uad6d CBS \uc778\ud130\ub137\ud310\uc740 \u2018\uc784\uc2e0 \ucd08\uae30\ub098 \uc218\uc815 \ub2e8\uacc4\uc5d0\uc11c \uc544\uc2a4\ud53c\ub9b0\uc744 \uba39\uc73c\uba74 \uc720\uc0b0 \ud655\ub960\uc774 80%\uc5d0 \uc774\ub978\ub2e4\u2019\ub294 \ub0b4\uc6a9\uc744 \ud55c \uc758\ud559\uc790\uc758 \ub9d0\uc744 \uc778\uc6a9\ud574 \ubcf4\ub3c4\ud588\ub2e4. 1\uc6d4\uc5d0\ub294 \ub354 \uc2ec\uac01\ud55c \ub0b4\uc6a9\uc774 \uacf5\uac1c\ub418\uc5c8\ub2e4. \ubbf8\uad6d \ud558\ubc84\ub4dc \uc758\ub300 \uc5d0\ubc14 \uc250\ub978 \ubc15\uc0ac\uac00 \uc544\uc2a4\ud53c\ub9b0\uc744 \uc7a5\uae30 \ubcf5\uc6a9\ud574\uc628 \uc5ec\uc131 8\ub9cc8\ucc9c\uba85\uc744 18\ub144\uac04 \ucd94\uc801\ud55c \uacb0\uacfc, 1\uc8fc\uc77c\uc5d0 325mg \uc774\uc0c1\uc744 \uc7a5\uae30 \ubcf5\uc6a9\ud55c \uc0ac\ub78c\uc774 \uac00\ub054 \ubcf5\uc6a9\ud55c \uc0ac\ub78c\uc5d0 \ube44\ud574 \ucdcc\uc7a5\uc554\uc5d0 \uac78\ub9b4 \uc704\ud5d8\uc774 58%\ub098 \ub192\uc558\ub2e4. \ub610 20\ub144 \ub3d9\uc548 1\uc8fc\uc77c\uc5d0 14\uc815 \uc774\uc0c1 \ubcf5\uc6a9\ud55c \uc0ac\ub78c\uc740 \uc804\ud600 \ubcf5\uc6a9\ud558\uc9c0 \uc54a\uc740 \uc0ac\ub78c\uc5d0 \ube44\ud574 \ucdcc\uc7a5\uc554 \ubc1c\ubcd1 \uc704\ud5d8\uc774 86%\ub098 \ub192\uc558\ub2e4.<\/p>\n<p>2002\ub144 \ud55c\uad6d\uc5d0\uc11c \uc0ac\ub9dd\ud55c \uc0ac\ub78c\uc740 \ubaa8\ub450 24\ub9cc7\ucc9c \uba85. \uadf8 \uac00\uc6b4\ub370 \uc0ac\ub9dd\uc790\ub97c \uac00\uc7a5 \ub9ce\uc774 \ub0b8 \uc9c8\ubcd1\uc740 \uc554\uc774\uc5c8\uc73c\uba70, \uadf8 \ub2e4\uc74c\uc73c\ub85c \uc0ac\ub9dd\uc790\ub97c \ub9ce\uc774 \ub0b8 \uc9c8\ubcd1\uc740 \ub1cc\ud608\uad00\uc9c8\ud658\u00b7\uc2ec\uc7a5\uc9c8\ud658\u00b7\ub2f9\ub1e8\ubcd1 \uc21c\uc11c\uc600\ub2e4. \uc774 \ud1b5\uacc4\ub294 \ud55c\uad6d\uc758 \ub9ce\uc740 \uc0ac\ub78c\uc5d0\uac8c \uc544\uc2a4\ud53c\ub9b0\uc774 \ud544\uc694\ud568\uc744 \ub73b\ud55c\ub2e4. \uadf8\ub7ec\ub098 \ub9ce\uc740 \uc0ac\ub78c\uc774 \uc544\uc2a4\ud53c\ub9b0\uc5d0 \ub300\ud574 \ubb34\uc9c0\ud558\ub2e4. \ubb3c\ub860 \ubaa8\ub4e0 \uc0ac\ub78c\uc774 \uadf8 \uc57d\uc744 \uba39\uc5b4\uc57c \ud55c\ub2e4\ub294 \ub73b\uc740 \uc544\ub2c8\ub2e4.<\/p>\n<p>\ub958\uc655\uc131 \uad50\uc218\ub294 \u201c\uc801\uc5b4\ub3c4 \uc2ec\uadfc\uacbd\uc0c9\uc99d\u00b7\ubd88\uc548\uc815\ud615 \ud611\uc2ec\uc99d\u00b7\uc548\uc815\ud615 \ud611\uc2ec\uc99d\u00b7\ub1cc\uacbd\uc0c9\u00b7\uc77c\uacfc\uc131 \ub1cc\ud5c8\ud608 \ud658\uc790\ub294 2\ucc28 \ubc1c\ubcd1\uc744 \ub9c9\uae30 \uc704\ud574 \ubcf5\uc6a9\ud558\ub294 \uac83\uc774 \uc88b\ub2e4\u201d\ub77c\uace0 \ub9d0\ud55c\ub2e4. \ub3d9\ub9e5\uacbd\ud654 \uc704\ud5d8 \uc6d0\uc778(\uace0\ud608\uc555\u00b7\ub2f9\ub1e8\u00b7\ud761\uc5f0\u00b7\uace0\ucf5c\ub808\uc2a4\ud14c\ub864) \uac00\uc6b4\ub370 \ub450 \uac00\uc9c0 \uc774\uc0c1\uc744 \uc9c0\ub2cc \uc0ac\ub78c\ub3c4 \ubcf5\uc6a9 \ub300\uc0c1\uc790\uc774\ub2e4. \uadf8\ub807\ub2e4\uba74 \uac00\uc871 \ubcd1\ub825\uc5d0 \uc2ec\ud608\uad00\uacc4 \uc9c8\ud658\uc774\ub098 \ub2f9\ub1e8\uac00 \uc788\ub2e4\uba74 \uc608\ubc29 \ucc28\uc6d0\uc5d0\uc11c \uc544\uc2a4\ud53c\ub9b0\uc744 \ubcf5\uc6a9\ud558\ub294 \uac83\uc774 \uc88b\uc9c0 \uc54a\uc744\uae4c. \uae00\uc384, \uadf8\ub7f0 \ubd84\uc774\ub77c\uba74 \uba3c\uc800 \uc758\uc0ac\uc640 \uc0c1\uc758\ud558\uae30\ub97c \uad8c\ud55c\ub2e4.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; (\uc6d0\ubb38) &nbsp; &nbsp; GIB\u00a0\uc81c\uacf5 &nbsp; \uc544\uc2a4\ud53c\ub9b0\uc740 \ud608\uad00\uc5d0 \ubb3c\uc9c8\uc774 \uc313\uc774\ub294 \uac83\uc744 \ub9c9\ub294\ub2e4\uace0 \uc54c\ub824\uc838\uc654\ub2e4. \uc774\ub7f0 \uc774\uc720\ub85c \uac74\uac15\ud55c \uc0ac\ub78c \uc911\uc5d0\uc11c\ub3c4 \uc2ec\uc7a5 \ubd80\ub2f4\uc744 \uc904\uc77c \ubaa9\uc801\uc73c\ub85c \uc18c\ub7c9\uc758 \uc544\uc2a4\ud53c\ub9b0\uc744<a href=\"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1754\" class=\"more-link\">(more&#8230;)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[41,38,32,33,34,29],"tags":[],"class_list":["post-1754","post","type-post","status-publish","format-standard","hentry","category-05---","category-38","category-essays-on-science","category-do-biology","category-lets-do-chemistry","category-lets-do-science"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":2224,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2224","url_meta":{"origin":1754,"position":0},"title":"\ube44\uc544\uadf8\ub77c\uc640 \uc544\uc2a4\ud53c\ub9b0\uc758 \uc815\uccb4 &#038; &#8216;\ube44\uc544\uadf8\ub77c&#8217; \ub73b\ubc16 \ud6a8\ub2a5 \uc5b4\ub514\uae4c\uc9c0\u2026\uce58\ub9e4 \uc774\uc5b4 \uc2dd\ub3c4\uc554 \uc0dd\uc874\uc728\ub3c4 \ub192\uc5ec","author":"biochemistry","date":"December 3, 2018","format":false,"excerpt":"\u00a0 \u00a0 \ube44\uc544\uadf8\ub77c\ub294 \uc6d0\ub798 \uace0\ud608\uc555 \uce58\ub8cc\uc81c\ub85c \uac1c\ubc1c\ub410\ub294\ub370 \uc5b4\uca4c\ub2e4 \ubc1c\uae30\ubd80\uc804 \uce58\ub8cc\uc81c\uac00 \ub410\uc744\uae4c\uc694? 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Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxODA3MDVfMTc2\/MDAxNTMwNzQwMzIzNDY2.uB4gNg12vPxDonQhF7k5kmFaIN3WVe6yCXFcnY1Z6Tgg.qhYmPr_OJqhMql9-i_BJOp5OFWK6uGEQ8juGWQbRiJsg.JPEG\/%EB%84%A4%EC%9D%B4%EB%B2%84%ED%8F%AC%EC%8A%A4%ED%8A%B8_7.4.jpg?resize=350%2C200&ssl=1","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxODA3MDVfMTc2\/MDAxNTMwNzQwMzIzNDY2.uB4gNg12vPxDonQhF7k5kmFaIN3WVe6yCXFcnY1Z6Tgg.qhYmPr_OJqhMql9-i_BJOp5OFWK6uGEQ8juGWQbRiJsg.JPEG\/%EB%84%A4%EC%9D%B4%EB%B2%84%ED%8F%AC%EC%8A%A4%ED%8A%B8_7.4.jpg?resize=350%2C200&ssl=1 1x, https:\/\/i0.wp.com\/post-phinf.pstatic.net\/MjAxODA3MDVfMTc2\/MDAxNTMwNzQwMzIzNDY2.uB4gNg12vPxDonQhF7k5kmFaIN3WVe6yCXFcnY1Z6Tgg.qhYmPr_OJqhMql9-i_BJOp5OFWK6uGEQ8juGWQbRiJsg.JPEG\/%EB%84%A4%EC%9D%B4%EB%B2%84%ED%8F%AC%EC%8A%A4%ED%8A%B8_7.4.jpg?resize=525%2C300&ssl=1 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\ub2a5\ub825\uc744 \uc9c0\ub154\ub2e4.\u00a0\uc601\uad6d \uc5f0\uad6c\uc9c4\uc774 \uc774 \ub2a5\ub825\uc5d0 \uac00\uc7a5 \uc5f0\uad00\ub418\ub294 \uc720\uc804\uc790\uac00 \ubb34\uc5c7\uc778\uc9c0 \ubc1d\ud600\ub0c8\ub2e4.\u00a0\uc2ec\uc7a5\uc9c8\ud658 \uce58\ub8cc\uc5d0 \uc0c8\ub85c\uc6b4 \uae38\uc774 \uc5f4\ub9b4\uc9c0 \uc8fc\ubaa9\ub41c\ub2e4. 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Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1794,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1794","url_meta":{"origin":1754,"position":5},"title":"\uac10\uc815\u00b7\ud589\ub3d9 \uc601\ud5a5 \ubbf8\uce58\ub294 \ubcf5\uc7a1\ud55c &#8216;\uc138\ub85c\ud1a0\ub2cc \uc2dc\uc2a4\ud15c&#8217;","author":"biochemistry","date":"September 22, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 [\uc694\uc57d] \uc2a4\ud0e0\ud37c\ub4dc\ub300 \uc5f0\uad6c\uc9c4\uc774 \uc778\uac04\uc758 \uae30\ubd84\uacfc \ud589\ub3d9 \ub4f1 \ub9ce\uc740 \ubd80\ubd84\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ud638\ub974\ubaac\uc778 \uc138\ub85c\ud1a0\ub2cc\uc774 \ub1cc \uc548\uc5d0\uc11c \uc11c\ub85c \ub2e4\ub978 \ubc29\uc2dd\uc73c\ub85c \uc804\ub2ec\ub418\uba74\uc11c \uc601\ud5a5\uc744 \ubbf8\uce5c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1c\uacac\ud588\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \uc774\ubc88 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