{"id":1738,"date":"2018-09-16T11:44:48","date_gmt":"2018-09-16T02:44:48","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=1738"},"modified":"2023-07-05T14:36:22","modified_gmt":"2023-07-05T05:36:22","slug":"unraveling-the-mystery-of-thalidomide","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1738","title":{"rendered":"Unraveling the mystery of thalidomide"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>(\uc6d0\ubb38: <a href=\"http:\/\/science.sciencemag.org\/content\/361\/6407\/1084.3?rss=1\">\uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><cite>Science\u00a0<\/cite>\u00a014 Sep 2018:<br \/>\nVol. 361, Issue 6407, pp. 1084-1085<br \/>\nDOI: 10.1126\/science.361.6407.1084-c<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>Off-label use of thalidomide became a worldwide trend in the 1950s and early 1960s to alleviate morning sickness. It resulted in a historical tragedy, as thousands of babies were born with severe birth defects. Donovan\u00a0<em>et al.<\/em>\u00a0may have found a missing link to explain how the drug affects fetal development. The researchers show that thalidomide and closely related drugs rapidly degrade the transcription factor Sal-like protein 4 (SALL4), which is necessary for fetal limb and organ formation. Adding further weight to their findings, certain individuals with mutations in the\u00a0<em>SALL4<\/em>gene develop abnormalities that resemble thalidomide-induced birth defects.<\/p>\n<p>&nbsp;<\/p>\n<p id=\"p-2\"><em>eLife<\/em>\u00a0<strong>7<\/strong>, e38430 (2018).<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>https:\/\/www.nature.com\/articles\/s41589-018-0134-0?utm_source=feedburner&#038;utm_medium=feed&#038;utm_campaign=Feed%3A+nchembio%2Frss%2Fcurrent+%28Nature+Chemical+Biology+-+Issue%29<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<header>\n<div class=\"grid grid-12 last\">\n<h5 class=\"tighten-line-height small-space-below\" data-test=\"article-title\">A new target for thalidomide<\/h5>\n<ul class=\"grid grid-12 last clean-list inline-list js-list-authors text14 js-etal-collapsed small-space-below\" data-etal=\"25\" data-etal-small=\"3\" data-test=\"authors-list\">\n<li><a class=\"icon icon-right-top icon-mail-12x9-blue pr15 js-no-scroll\" href=\"https:\/\/www.nature.com\/articles\/s41589-018-0134-0?utm_source=feedburner&amp;utm_medium=feed&amp;utm_campaign=Feed%3A+nchembio%2Frss%2Fcurrent+%28Nature+Chemical+Biology+-+Issue%29#auth-1\" data-test=\"author-name\" data-track=\"click\" data-track-action=\"open author\" data-track-category=\"article body\" data-track-label=\"link\" data-corresp-id=\"c1\">Peter G. Wells<\/a><\/li>\n<\/ul>\n<div class=\"grid-12 cleared\" data-container-section=\"info\">\n<p class=\"text14 standard-space-below\"><i data-test=\"journal-title\">Nature Chemical Biology\u00a0<\/i><b data-test=\"journal-volume\"><span class=\"visually-hidden\">volume<\/span>\u00a014<\/b>,\u00a0<span class=\"visually-hidden\">pages\u00a0<\/span>904\u2013905\u00a0(<span data-test=\"article-publication-year\">2018<\/span>)\u00a0<span class=\"pl6 pr6 text-gray-extra-light\">|\u00a0<\/span><a class=\"pr15 icon icon-right icon-download\" href=\"https:\/\/www.nature.com\/articles\/s41589-018-0134-0.ris\" data-test=\"citation-link\" data-track=\"click\" data-track-action=\"download article citation\" data-track-category=\"article body\" data-track-label=\"link\">Download Citation<\/a><\/p>\n<\/div>\n<\/div>\n<\/header>\n<div class=\"article-body clear\" data-article-body=\"true\" data-track-component=\"article body\">\n<div class=\"pl20 mq875-pl0 serif\">\n<div id=\"stand-first\" class=\"strong\">\n<p>One mechanism of thalidomide teratogenicity involves binding to the CUL4\u2013CRBN E3 ubiquitin ligase complex, which then mediates the degradation of transcription factors. New studies reveal that species-specific variants of the transcription factor SALL4 are differentially ubiquitinated and degraded via the thalidomide-bound complex.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; &nbsp; (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) &nbsp; &nbsp; Science\u00a0\u00a014 Sep 2018: Vol. 361, Issue 6407, pp. 1084-1085 DOI: 10.1126\/science.361.6407.1084-c &nbsp; &nbsp; Off-label use of thalidomide became<a href=\"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1738\" class=\"more-link\">(more&#8230;)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[32,33,34,29,30],"tags":[],"class_list":["post-1738","post","type-post","status-publish","format-standard","hentry","category-essays-on-science","category-do-biology","category-lets-do-chemistry","category-lets-do-science","category-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":2863,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2863","url_meta":{"origin":1738,"position":0},"title":"Protein-slaying drugs could be the next blockbuster therapies","author":"biochemistry","date":"March 20, 2019","format":false,"excerpt":"\u00a0 \u00a0 Researchers are hijacking the cell\u2019s protein-disposal system in the fight against Alzheimer\u2019s and intractable cancers. \u00a0 \u00a0 Illustration by David Parkins \u00a0PDF version \u00a0 \u00a0 When Craig Crews first managed to make proteins disappear on command with a bizarre new compound, the biochemist says that he considered it\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3984,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3984","url_meta":{"origin":1738,"position":1},"title":"Enriching stem cells for gene editing","author":"biochemistry","date":"August 3, 2019","format":false,"excerpt":"\u00a0 \u00a0 Gene editing using CRISPR-Cas9 may allow targeted treatment for a variety of genetic diseases. These include inherited abnormalities of \u03b2 hemoglobin, which can be indirectly targeted by increasing the amount of healthy fetal hemoglobin without fully correcting the disease-causing mutation. Humbert\u00a0et al.\u00a0used CRISPR-based gene editing to modify hematopoietic\u2026","rel":"","context":"In &quot;Let's Do Biology!&quot;","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3477,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3477","url_meta":{"origin":1738,"position":2},"title":"Gene editing fixes cystic fibrosis gene in mice before birth","author":"biochemistry","date":"May 9, 2019","format":false,"excerpt":"\u00a0 Administration of nanoparticles\u00a0in utero\u00a0repaired the mutated\u00a0Cftr\u00a0gene \u00a0 The airway of the lungs in cystic fibrosis (pictured here) is clogged with mucus, causing the severe breathlessness seen in this inheritable condition. 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Between 1970 and 2014, real GDP per hour worked, a measure of labour productivity, grew by an average of just 1.62% per year in the United\u2026","rel":"","context":"In &quot;Essays on Science&quot;","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1865,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1865","url_meta":{"origin":1738,"position":4},"title":"Receptor dynamics predict drug effects","author":"biochemistry","date":"September 25, 2018","format":false,"excerpt":"\u00a0 \u00a0 Science\u00a0\u00a021 Sep 2018: Vol. 361, Issue 6408, pp. 1211-1213 DOI: 10.1126\/science.361.6408.1211-r \u00a0 (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) \u00a0 The effect of a drug on a G protein\u2013coupled receptor (GPCR) can be determined by monitoring the downstream effects of that receptor, but not for GPCRs whose signaling pathways are unclear. 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