{"id":1683,"date":"2018-09-12T09:35:34","date_gmt":"2018-09-12T00:35:34","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=1683"},"modified":"2023-07-05T14:37:36","modified_gmt":"2023-07-05T05:37:36","slug":"%ec%9e%91%ec%9d%80-rna-%ec%a1%b0%ea%b0%81-%ec%9c%a0%ec%a0%84%ec%9e%90-%ec%a7%88%ed%99%98-%ea%b7%b9%eb%b3%b5%ec%9d%98-%ec%97%b4%ec%87%a0-%eb%90%a0%ea%b9%8c","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1683","title":{"rendered":"\uc791\uc740 RNA \uc870\uac01, \uc720\uc804\uc790 \uc9c8\ud658 \uadf9\ubcf5\uc758 \uc5f4\uc1e0 \ub420\uae4c & RNA \uc804\uc0ac\uccb4\uac00 \uc88c\uc6b0\ud558\ub294 \uc138\ud3ec\uc758 \uc6b4\uba85"},"content":{"rendered":"

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(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n

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RNA \uac04\uc12d\uc774 \uc720\uc804\uc790 \ubc1c\ud604\uc744 \uc870\uc808\ud55c\ub2e4?<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc0dd\uba85\uc5d0 \uad00\ud55c \uc720\uc804\uc815\ubcf4\ub97c \ub2f4\uace0 \uc788\ub294\u00a0DNA<\/span>\ub294\u00a0\ub450 \uac00\ub2e5\uc758 \uc774\uc911\ub098\uc120 \uad6c\uc870\ub97c \uc774\ub8e8\uace0 \uc788\ub2e4. DNA<\/span>\uc758 \uc720\uc804\uc815\ubcf4\ub97c \ub530\ub77c\u00a0RNA<\/span>\uac00 \ub9cc\ub4e4\uc5b4\uc9c0\uace0,\u00a0<\/span>RNA<\/span>\ub294 \uc6d0\ubcf8\u00a0DNA<\/span>\uac00 \uac00\uc9c4 \uc815\ubcf4\ub97c \ubcf5\uc0ac\ud574 \uc720\uc804\uc790 \ubc1c\ud604\uc744 \uc870\uc808\ud558\uace0 \ub2e8\ubc31\uc9c8 \ud569\uc131\uc5d0 \uc911\ucd94\uc801 \uc5ed\ud560\uc744 \uc218\ud589\ud55c\ub2e4.\u00a0<\/span>\uacfc\uac70\u00a0RNA<\/span>\ub294\u00a0DNA<\/span>\ub97c \uad6c\uc131\ud558\ub294 \uc218\ub3d9\uc801\uc778 \uc874\uc7ac\ub85c \uc5ec\uaca8\uc84c\uc73c\ub098 \uc810\ucc28 \uadf8 \uc911\uc694\uc131\uc774 \ud06c\uac8c \ub300\ub450\ub418\uace0 \uc788\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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RNA<\/span>\ub294 \ub9e4\uc6b0 \uc548\uc815\uc801\uc778\u00a0DNA<\/span>\uc640 \ub2ec\ub9ac \ud65c\ub3d9\uc801\uc774\ub2e4.\u00a0<\/span>\ub2e4\ub978 \ub9d0\ub85c \ud45c\ud604\ud558\uba74 \uc5b4\ub514\ub85c \ud288\uc9c0 \ubaa8\ub978\ub2e4. DNA<\/span>\ub97c \uc774\uc911\uac00\ub2e5\uc758 \uaf49 \ub2eb\ud78c \uc9c0\ud37c\ub85c \ube44\uc720\ud55c\ub2e4\uba74, RNA<\/span>\ub294 \ub2e8\uc77c\uac00\ub2e5\uc758 \uc5f4\ub9b0 \uc9c0\ud37c\ub2e4. DNA<\/span>\uc5d0\uc11c\u00a0RNA<\/span>\ub85c \uc804\uc0ac\uac00 \uc77c\uc5b4\ub0a0 \ub54c, DNA<\/span>\ub294\u00a0RNA<\/span>\ub97c \ub9cc\ub4e4 \uc218 \uc788\ub3c4\ub85d \uc9c0\ud37c\uc758 \uc911\uc559\uc744 \uc0b4\uc9dd \uc5f4\uc5b4\uc900\ub2e4. DNA\u00a0<\/span>\uc9c0\ud37c\uc5d0 \uaf2d \ub9de\ub294\u00a0RNA\u00a0<\/span>\uc9c0\ud37c \uc870\uac01\uc774 \ud558\ub098\uc529 \ucc28\ub840\ucc28\ub840 \ub2ec\ub77c\ubd99\uc5b4 \uc804\ub839RNA(mRNA)<\/span>\ub97c \ub9cc\ub4dc\ub294 \uc804\uc0ac \uacfc\uc815\uc774 \ub05d\ub098\uba74\u00a0DNA<\/span>\ub294 \uc5f4\uc5c8\ub358 \uc9c0\ud37c\ub97c \ud669\uae09\ud788 \ub2eb\uc544 \uc720\uc804\uc815\ubcf4\ub97c \ubcf4\uc874\ud55c\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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RNA<\/i><\/span>\ub294 \ud65c\ub3d9\uc131\uc774 \ub192\uae30 \ub54c\ubb38\uc5d0 \ub2e4\ub978\u00a0<\/i>DNA, RNA<\/i><\/span>\uc640 \uc27d\uac8c \ubd99\ub294\ub2e4<\/i>.\u00a0<\/i><\/span>\uc774\ub7f0 \uc131\uc9c8 \ub54c\ubb38\uc5d0\u00a0<\/i>RNA<\/i><\/span>\ub294 \uc0dd\uccb4 \ub0b4\uc5d0\uc11c \ub2e4\uc591\ud55c \uc5ed\ud560\uc744 \uc218\ud589\ud560 \uc218 \uc788\ub2e4<\/i>. \u2018RNA\u00a0<\/i><\/span>\uac04\uc12d<\/i>\u2019\u00a0<\/i><\/span>\ud604\uc0c1\ub3c4\u00a0<\/i>RNA<\/i><\/span>\uc758 \uc774\ub7f0 \uc131\uc9c8 \ub54c\ubb38\uc5d0 \uc77c\uc5b4\ub09c\ub2e4<\/i>.\u00a0<\/i><\/span>\uc608\ub97c \ub4e4\uc5b4 \ub2e8\ubc31\uc9c8 \uc0dd\uc131\uc744 \uc704\ud574\uc11c \ub9cc\ub4e4\uc5b4\uc9c4\u00a0<\/i>mRNA<\/i><\/span>\uc5d0 \uaf2d \ub9de\ub294 \uc9dd\uc744 \uac00\uc9c4 \uc9e7\uc740\u00a0<\/i>RNA\u00a0<\/i><\/span>\uc870\uac01\uc774 \uc788\ub2e4\uba74 \ud574\ub2f9\u00a0<\/i>mRNA<\/i><\/span>\uc5d0 \ub2ec\ub77c\ubd99\uc744 \uac83\uc774\ub2e4<\/i>.\u00a0<\/i><\/span>\ub2e4\uc2dc \ub9d0\ud574 \uc9e7\uc740\u00a0<\/i>RNA\u00a0<\/i><\/span>\uc870\uac01\uc774 \uc138\ud3ec\uc9c8 \uc548\uc5d0\uc11c \ub3cc\uc544\ub2e4\ub2c8\ub2e4\uac00 \uc5fc\uae30\uc11c\uc5f4\uc774 \uaf2d \ub9de\ub294 \ubd80\uc704\ub97c \uac00\uc9c4\u00a0<\/i>mRNA<\/i><\/span>\ub97c \ub9cc\ub098\uba74 \ub4e4\ub7ec\ubd99\ub294\ub2e4<\/i>.\u00a0<\/i><\/span>\uc774\ub807\uac8c \ub418\uba74\u00a0<\/i>mRNA<\/i><\/span>\ub294 \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4e4\uc5b4\ub0b4\uc9c0 \ubabb\ud558\uace0 \uc791\uc740 \uc870\uac01\uc73c\ub85c \ubd80\uc11c\uc838 \uc5c6\uc5b4\uc9c4\ub2e4<\/i>.\u00a0<\/i><\/span>\uc9e7\uc740\u00a0<\/i>RNA\u00a0<\/i><\/span>\uc870\uac01\uc774 \ubd88\ud544\uc694\ud55c\u00a0<\/i>RNA<\/i><\/span>\ub97c \uc5c6\uc560\ub294 \uccad\uc18c\ubd80\uc778 \uc148\uc774\ub2e4<\/i>.<\/i><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc0dd\uba85\uacfc\ud559\uacc4\uc5d0\uc11c\ub294\u00a0<\/i>RNA\u00a0<\/i><\/span>\uc0ac\uc2ac\uc5d0 \ubd99\uc5b4 \uc788\ub294 \uc544\uc8fc \uc791\uc740\u00a0<\/i>RNA(micro RNA, miRNA)<\/i><\/span>\uc5d0 \uc8fc\ubaa9\ud558\uace0 \uc788\ub2e4<\/i>.\u00a0<\/i><\/span>\uc774\ubbf8 \uc2dc\uc791\ub41c \uc9c8\ud658\uc758 \uc99d\uc0c1\uc744 \uc644\ud654\ud558\uac70\ub098 \ubab8\uc18d\uc5d0 \uc788\ub294 \uc9c8\ubcd1\uc778\uc790\ub97c \uc5c6\uc560\ub294 \uce58\ub8cc\uac00 \uc544\ub2c8\ub77c\u00a0<\/i>miRNA<\/i><\/span>\ub97c \uc99d\uac00\uc2dc\ud0a4\uac70\ub098 \uac10\uc18c\uc2dc\ucf1c \uc720\uc804\uc790\uac00 \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4dc\ub294 \uc815\ub3c4\ub97c \uc5b5\uc81c\ud558\uba74 \ub41c\ub2e4\ub294 \uc0dd\uac01\uc5d0\uc11c\ub2e4<\/i>.<\/i><\/span><\/p>\n

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\ud65c\ub3d9\uc131\uc774 \ub192\uc740 RNA\ub294 \ub2e4\ub978 DNA\ub098 RNA\uc5d0 \uc27d\uac8c \ubd99\ub294\ub2e4. \uc774\ub7f0 \uc131\uc9c8 \ub54c\ubb38\uc5d0 RNA \uac04\uc12d \ud604\uc0c1\ub3c4 \ub098\ud0c0\ub09c\ub2e4. \uc720\uc804\uc790 \uce58\ub8cc\uc81c \uac1c\ubc1c\uc758 \uc5f4\uc1e0\ub97c \uc950\uace0 \uc788\ub294 RNA \uac04\uc12d \ud604\uc0c1\uc740 \ucd5c\uadfc \uc804 \uc138\uacc4 \uc5f0\uad6c\uc9c4\ub4e4\uc774 \uc8fc\ubaa9\ud558\uace0 \uc5f0\uad6c \uc911\uc774\ub2e4. (\uc774\ubbf8\uc9c0 \ucd9c\ucc98: \uad6c\uae00)<\/span><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc608\uc05c\uaf2c\ub9c8\uc120\ucda9\uc5d0\uc11c \ubc1c\uacac\ub41c \uc9e7\uc740 RNA \uc870\uac01, \uac04\uc12d\uc758 \uc2dc\uc791\uc744 \uc54c\ub9ac\ub2e4<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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2006<\/span>\ub144 \ub178\ubca8 \uc0dd\ub9ac\uc758\ud559\uc0c1\uc740\u00a0\u2018RNA\u00a0<\/span>\uac04\uc12d(interference)\u2019\u00a0<\/span>\ud604\uc0c1\uc744 \ubc1c\uacac\ud55c \uc0dd\ubb3c\ud559\uc790 \ub450 \uc0ac\ub78c\uc5d0\uac8c \uc218\uc5ec\ub418\uc5c8\ub2e4.\u00a0<\/span>\uae30\uc874\uc5d0 \uc54c\ub824\uc9c4 \uc720\uc804\uc790 \uc870\uc808 \uba54\ucee4\ub2c8\uc998\uc5d0\uc11c\ub294 \uc0dd\uac01\ud560 \uc218 \uc5c6\uc5c8\ub358 \ubc29\uc2dd\uc744 \ubc1c\uacac\ud55c \uacf5\ub85c\ub2e4. RNA\u00a0<\/span>\uac04\uc12d \ud604\uc0c1\uc744 \ucc98\uc74c \ubaa9\uaca9\ud55c \uc0ac\ub78c\uc740\u00a01993<\/span>\ub144 \ub2f9\uc2dc \ud558\ubc84\ub4dc\ub300 \uc18c\uc18d(<\/span>\ud604\uc7ac\ub294 \ub9e4\uc0ac\ucd94\uc138\uce20 \uc758\ub300 \uad50\uc218)\u00a0<\/span>\ube45\ud130 \uc554\ube0c\ub85c\uc2a4 \ubc15\uc0ac\uc600\ub2e4.\u00a0<\/span>\uadf8\ub294 \uc608\uc05c\uaf2c\ub9c8\uc120\ucda9(<\/span>C. elegans<\/span>)<\/span>\uc758 \uc720\uc804\uc790 \ubcf5\uc81c \uacfc\uc815\uc5d0\uc11c\u00a022<\/span>\uac1c\uc758 \uc5fc\uae30\ub85c \uc774\ub904\uc9c4 \uc9e7\uc740\u00a0RNA<\/span>\ub4e4\uc774 \uc791\uc6a9\ud558\uba74 \uc608\uc05c\uaf2c\ub9c8\uc120\ucda9\uc758 \uc131\uc7a5\uc774 \uc5b5\uc81c\ub41c\ub2e4\ub294 \uac83\uc744 \ubc1c\uacac\ud588\ub2e4.\u00a0<\/span>\uc774\ub54c\uae4c\uc9c0\ub9cc \ud574\ub3c4 \uc554\ube0c\ub85c\uc2a4 \ubc15\uc0ac\ub294 \uac04\uc12d\uc774\ub77c\ub294 \ud45c\ud604\uc744 \uc4f0\uc9c0 \uc54a\uc558\ub2e4.\u00a0<\/span>\ub2e8\uc9c0 \uae38\uc774\uac00 \uc9e7\uc740\u00a0RNA\u00a0<\/span>\uc870\uac01\uc774 \uc0dd\uccb4\uc5d0\uc11c \uc5b4\ub5a4 \uc791\uc6a9\uc744 \ud560 \uc218 \uc788\ub294\uc9c0 \ucc98\uc74c\uc73c\ub85c \uc5ff\ubcf8 \uc5f0\uad6c \uacb0\uacfc\uc600\uc744 \ubfd0\uc774\ub2e4.\u00a0<\/span>\uc554\ube0c\ub85c\uc2a4 \ubc15\uc0ac\uac00 \ubc1c\uacac\ud55c \uc9e7\uc740\u00a0RNA\u00a0<\/span>\uc870\uac01\uc740\u00a02001<\/span>\ub144\uc5d0\uc57c \ub9c8\uc774\ud06c\ub85c\u00a0RNA(miRNA)<\/span>\ub77c\ub294 \uc774\ub984\uc774 \ubd99\uc5b4 \uc870\uae08\uc529 \ud559\uacc4\uc5d0 \uc54c\ub824\uc9c0\uae30 \uc2dc\uc791\ud588\ub2e4. miRNA<\/span>\ub294 \uc774\ub984\uc5d0\uc11c \uc54c \uc218 \uc788\ub4ef\u00a0\u2018<\/span>\uc544\uc8fc \uc791\uc740\u2019 RNA<\/span>\ub97c \ub9d0\ud55c\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc138\ud3ec \uc548\uc5d0\uc11c\u00a0miRNA\u00a0<\/span>\uc5fc\uae30\uc11c\uc5f4\ub4e4\uc774 \ub2e8\ubc31\uc9c8 \ud569\uc131\uc774 \uc2dc\uc791\ub418\uc9c0 \ubabb\ud558\uac8c\u00a0mRNA<\/span>\ub97c \ub9c9\uc544\uc11c\ub294 \ud604\uc0c1\uc740\u00a01998<\/span>\ub144\uc5d0 \ud559\uacc4\uc5d0 \ubcf4\uace0\ub418\uc5c8\ub2e4.\u00a0<\/span>\uc554\ube0c\ub85c\uc2a4 \ubc15\uc0ac\uac00 \uc608\uc05c\uaf2c\ub9c8\uc120\ucda9\uacfc \uc9e7\uc740\u00a0RNA<\/span>\uc758 \uc791\uc6a9\uc744 \ubc1c\uacac\ud558\uace0\u00a05<\/span>\ub144\uc774 \uc9c0\ub09c \uc2dc\uc810\uc774\uc5c8\ub2e4.\u00a0<\/span>\uc554\ube0c\ub85c\uc2a4 \ubc15\uc0ac\uc640 \uce74\ub124\uae30\uc5f0\uad6c\uc18c\uc758 \uc564\ub4dc\ub8e8 \ud30c\uc774\uc5b4 \ubc15\uc0ac(<\/span>\ud604\uc7ac \uc2a4\ud0e0\ud37c\ub4dc\ub300 \uc758\ub300 \uad50\uc218)<\/span>\ub294 \uc6b0\uc5f0\ud788 \ub2e8\uc77c\uac00\ub2e5\uc758\u00a0RNA\u00a0<\/span>\uc5fc\uae30\ub4e4\uc744 \uacb0\ud569\uc2dc\ud0a8 \uc774\uc911\uac00\ub2e5\uc758\u00a0RNA<\/span>\ub97c \uc608\uc05c\uaf2c\ub9c8\uc120\ucda9\uc758 \uc138\ud3ec \uc548\uc5d0 \uc8fc\uc785\ud558\uc790\u00a0\uc9dd\uc774 \ub9de\ub294\u00a0RNA<\/span>\ub9cc \ud2b9\uc774\uc801\uc73c\ub85c \ud30c\uad34\ub418\uba74\uc11c \uc720\uc804\uc790 \ubc1c\ud604\uc774 \uc5b5\uc81c\ub41c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc54c\uc544\ub0c8\ub2e4.\u00a0<\/span>\ub450 \uc5f0\uad6c\uc790\ub294 \uc774 \ud604\uc0c1\uc744\u00a0RNA\u00a0<\/span>\uac04\uc12d\uc774\ub77c \uba85\uba85\ud558\uace0,\u00a0<\/span>\uace7\ubc14\ub85c \uc774\ub97c \ud559\uc220\uc9c0 \ub124\uc774\ucc98\uc5d0 \ubc1c\ud45c\ud588\ub2e4.<\/span><\/p>\n

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1953\ub144 DNA\uc774\uc911\ub098\uc120\uc774 \ubc1d\ud600\uc9c4 \ub4a4 \uacfc\ud559\uc790\ub4e4\uc740 DNA\uc758 \uc5fc\uae30 \uc11c\uc5f4 \uc815\ubcf4\uac00 \uc5b4\ub5bb\uac8c \ub2e8\ubc31\uc9c8\uc758 \uc544\ubbf8\ub178\uc0b0 \uc11c\uc5f4\ub85c \ubc88\uc5ed\ub418\ub294\uc9c0 \ubc1d\ud78c \uc5f0\uad6c\uc5d0 \ub6f0\uc5b4\ub4e4\uc5c8\ub2e4. \uadf8 \uacb0\uacfc DNA\uac00 \uba3c\uc800 \uac19\uc740 \uc5fc\uae30\uc21c\uc11c\uc778 \ub2e8\uc77c\uac00\ub77d \uc804\ub839RNA(mRNA)\ub85c \uc804\uc0ac\ub41c \ub4a4 \ub9ac\ubcf4\uc19c\uc5d0\uc11c mRNA\ub97c \uc77d\uc5b4 \ubc88\uc5ed\uc774 \uc77c\uc5b4\ub09c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uaddc\uba85\ud588\ub2e4. (\uc0ac\uc9c4 : THE NOVEL PRIZE, \ub0b4\uc6a9 : \ub3d9\uc544\uc0ac\uc774\uc5b8\uc2a4)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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RNA\u00a0<\/span>\uac04\uc12d\uc740\u00a0RNA<\/span>\uac00 \ub274\ud074\ub85c\ub808\uc624\ud2f0\ub4dc \ud615\ud0dc\uc758\u00a0miRNA<\/span>\ub85c \uc804\ud658\ub41c \ub4a4 \uc138\ud3ec \ub0b4\u00a0mRNA<\/span>\ub97c \uc808\ub2e8,\u00a0<\/span>\ubd84\ud574\uc2dc\ud0a4\ub294 \uacfc\uc815\uc774\ub2e4.\u00a0<\/span>\ub274\ud074\ub808\uc624\ud2f0\ub4dc\ub294 \uc5fc\uae30,\u00a0<\/span>\ub2f9,\u00a0<\/span>\uc778\uc0b0\uc73c\ub85c \uc774\ub904\uc9c4 \ud654\ud569\ubb3c\ub85c\u00a0DNA<\/span>\ub098\u00a0RNA\u00a0<\/span>\uc0ac\uc2ac\uc744 \uc774\ub8e8\ub294 \uae30\ubcf8 \ub2e8\uc704\ub2e4.\u00a0<\/span>\ubcf4\ud1b5\uc758\u00a0RNA<\/span>\uac00 \uc218\ucc9c \uac1c\uc758 \ub274\ud074\ub808\uc624\ud2f0\ub4dc\ub85c \uc774\ub904\uc9c4 \ub370 \ubc18\ud574\u00a0miRNA<\/span>\ub294\u00a020~22<\/span>\uac1c\ub85c\u00a0\uc801\uace0, 4<\/span>\uac1c \uc5fc\uae30(<\/span>\uc544\ub370\ub2cc(A),\u00a0<\/span>\uad6c\uc544\ub2cc(G),\u00a0<\/span>\uc2dc\ud1a0\uc2e0(C),\u00a0<\/span>\uc6b0\ub77c\uc2e4(U))<\/span>\ub85c \uad6c\uc131\ub3fc \uc788\uc9c0\ub9cc\u00a0<\/span>\ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4e4\uc5b4\ub0b4\uc9c0 \ubabb\ud55c\ub2e4.\u00a0<\/span>\ub2e8\ubc31\uc9c8\uc744 \ubabb \ub9cc\ub4dc\ub294\u00a0RNA<\/span>\ub294 \uc9c0\uae08\uae4c\uc9c0 \uc0ac\ub78c \ubab8\uc18d\uc5d0\uc11c\ub9cc\u00a01<\/span>\ub9cc\u00a01665<\/span>\uc885 \uc774\uc0c1 \ubc1c\uacac\ub410\uace0,\u00a0<\/span>\uadf8 \uac00\uc6b4\ub370\u00a0miRNA<\/span>\ub294\u00a0700<\/span>\uc885\ucbe4 \ub41c\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc608\uc05c\uaf2c\ub9c8\uc120\ucda9\uc5d0\uc11c\u00a0RNA\u00a0<\/span>\uac04\uc12d \ud604\uc0c1\uc774 \ubc1c\uacac\ub41c \uc774\ud6c4,\u00a0<\/span>\ub9ce\uc740 \uacfc\ud559\uc790\ub4e4\uc5d0 \uc758\ud574 \ucd08\ud30c\ub9ac\uc640 \uac19\uc740 \ud558\ub4f1\ub3d9\ubb3c\uc5d0\uc11c\ubfd0 \uc544\ub2c8\ub77c \uc778\uac04\uc744 \ube44\ub86f\ud55c \ud3ec\uc720\ub3d9\ubb3c \uc138\ud3ec\uc5d0\uc11c\ub3c4\u00a0RNA\u00a0<\/span>\uac04\uc12d\uc774 \uc77c\uc5b4\ub09c\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ubc1d\ud600\uc84c\ub2e4. RNA\u00a0<\/span>\uac04\uc12d \ud604\uc0c1\uc740 \uc810\ucc28 \uc720\uc804\uc790 \uae30\ub2a5\uc744 \uc5f0\uad6c\ud558\uae30 \uc704\ud55c \ubc29\ubc95\uc73c\ub85c \uc77c\ubc18\ud654\ub418\uae30 \uc2dc\uc791\ud588\ub2e4.
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RNA \uac04\uc12d\uc744 \ud65c\uc6a9\ud55c \uce58\ub8cc \uad00\uac74\uc740 \uc57d\ubb3c \uc804\ub2ec \uc2dc\uc2a4\ud15c<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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RNA\u00a0<\/span>\uac04\uc12d \ud604\uc0c1\uc744 \uc774\uc6a9\ud55c \uc5f0\uad6c\ub294 \ud06c\uac8c \ub450 \uac00\uc9c0\ub85c \ub098\ub20c \uc218 \uc788\ub2e4.\u00a0<\/span>\uae30\ub2a5\uc744 \ubaa8\ub974\ub294 \uc720\uc804\uc790\ub97c \uc5b5\uc81c(Knock-down)<\/span>\ud558\uace0 \ub098\uc11c \uc138\ud3ec\uc758 \ubcc0\ud654\ub97c \uad00\ucc30\ud558\uac70\ub098 \uc9c8\ubcd1\uc758 \ubc1c\ubcd1\uc5d0 \uad00\ub828\ud558\ub294 \uc720\uc804\uc790\ub97c \uc5b5\uc81c\ud55c \ub4a4 \uc720\uc804\uc790 \uce58\ub8cc \ub4f1\uc5d0 \uc751\uc6a9\ud558\ub294 \uac83\uc774\ub2e4.\u00a0<\/span>\ud2b9\ud788 \ubc14\uc774\ub7ec\uc2a4 \uac10\uc5fc,\u00a0<\/span>\uc554 \ub4f1\uc744 \uc5f0\uad6c\ud558\ub294 \ubd84\uc57c\uc5d0 \uc720\uc6a9\ud558\ub2e4.\u00a0<\/span>\ubc14\uc774\ub7ec\uc2a4\ub098 \uc554\uc138\ud3ec\uac00 \ud574\ub85c\uc6b4 \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4e4\uc9c0 \ubabb\ud558\ub3c4\ub85d\u00a0RNA<\/span>\ub97c \ub123\uc5b4\uc8fc\uba74\u00a0<\/span>\uc218\u00a0\u339a(1<\/span>\ub098\ub178\ubbf8\ud130=10<\/span>\uc5b5\ubd84\uc758\u00a01m.\u00a0<\/span>\uba38\ub9ac\uce74\ub77d \uad75\uae30\uc758\u00a010<\/span>\ub9cc\ubd84\uc758\u00a01)<\/span>\u00a0<\/span>\uae38\uc774\uc758\u00a0<\/span>\uc18c\uac04\uc12dRNA(small interfering RNA, siRNA)<\/span>\uac00\u00a0RNA\u00a0<\/span>\uac04\uc12d \ud604\uc0c1\uc744 \uc720\ub3c4\ud560 \uc218 \uc788\ub2e4.\u00a0<\/span>\uc804\uc138\uacc4\uc758 \ub9ce\uc740 \uc5f0\uad6c\uc9c4\ub4e4\uacfc \uc81c\uc57d\ud68c\uc0ac\uc5d0\uc11c\u00a0<\/span>siRNA<\/span>\ub97c \ub300\uc0c1\uc73c\ub85c \uc2e0\uc57d\uac1c\ubc1c\uc774 \ud55c\ucc3d\uc778 \uc774\uc720\ub2e4.\u00a0<\/span>\ubc14\uc774\ub7ec\uc2a4\ub098 \uc554 \uc720\uc804\uc790\ub098 \uc720\uc804\uc9c8\ud658\uc744 \uc77c\uc73c\ud0a4\ub294 \ubcc0\uc774 \uc720\uc804\uc790\ub97c \ud45c\ud604\uc73c\ub85c \ud55c\u00a0RNA\u00a0<\/span>\uac04\uc12d \uc57d\ubb3c\uc774 \ub098\uc628\ub2e4\uba74 \uc758\ud559\uacc4\uc5d0 \ud601\uba85\uc774 \uc77c\uc5b4\ub0a0 \uac83\uc73c\ub85c \uc804\ub9dd\ub41c\ub2e4.\u00a0<\/span>
\n\ud604\uc7ac\uc758 \ud56d\uc554\uc81c\ub294 \uc554\uc138\ud3ec \ub2e8\ubc31\uc9c8\uc758 \ud2b9\uc815 \ubd80\uc704\uc5d0 \uacb0\ud569\ud558\ub294 \ubc29\uc2dd\uc774\ub2e4.\u00a0<\/span>\uc815\uc0c1 \uc138\ud3ec\uc758 \ub2e8\ubc31\uc9c8\uc5d0\ub3c4 \ub2ec\ub77c\ubd99\uc744 \uc218 \uc788\uc5b4 \ubd80\uc791\uc6a9\uc744 \uc77c\uc73c\ud0a8\ub2e4.\u00a0<\/span>\ud558\uc9c0\ub9cc\u00a0miRNA<\/span>\ub098\u00a0siRNA<\/span>\ub294 \ubaa9\ud45c\ud558\ub294 \ub2e8 \ud558\ub098\uc758 \ub2e8\ubc31\uc9c8\ub9cc \ub9c9\uc744 \uc218 \uc788\uae30 \ub54c\ubb38\uc5d0 \ubd80\uc791\uc6a9 \uc5c6\ub294 \ub9de\ucda4\ud615 \uc2e0\uc57d\uc744 \ub9cc\ub4e4\uae30\uc5d0 \uc548\uc131\ub9de\ucda4\uc774\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\ubb38\uc81c\ub294\u00a0siRNA<\/span>\ub97c \uc0dd\uccb4 \ud45c\uc801 \uc138\ud3ec\ub85c \uc774\ub3d9\uc2dc\ud0ac \uc774\uc0c1\uc801\uc778 \uc804\ub2ec\uccb4(<\/span>\uc57d\ubb3c \uc804\ub2ec \uc2dc\uc2a4\ud15c)<\/span>\uac00 \uc544\uc9c1 \uc5c6\ub2e4\ub294 \uac83. siRNA<\/span>\ub294 \ud608\uc561\uc744 \ud0c0\uace0 \ud750\ub974\ub294\ub370,\u00a0<\/span>\ud608\uc561 \uc18d\uc5d0\u00a0siRNA<\/span>\ub97c \uc778\uc2dd\ud574 \ud30c\uad34\ud558\ub294 \ud6a8\uc18c\uac00 \uc788\uc5b4 \uadf8\ub300\ub85c\ub294 \uc57d\ubb3c\ub85c \uc4f8 \uc218 \uc5c6\ub2e4.\u00a0<\/span>\ub530\ub77c\uc11c \ubaa9\uc801\uc9c0\uc778 \uc870\uc9c1\uc5d0 \ub3c4\ucc29\ud560 \ub54c\uae4c\uc9c0 \uc548\uc804\ud558\uac8c \uc6b4\ubc18\ud558\ub294 \uc804\ub2ec\uccb4\uac00 \ud544\uc694\ud558\ub2e4.\u00a0<\/span>\ud604\uc7ac\uae4c\uc9c0 \uac1c\ubc1c\ub41c \uc57d\ubb3c \uc804\ub2ec\uccb4\ub4e4\uc740 \uc804\ub2ec \ud6a8\uc728\uc774 \ub5a8\uc5b4\uc9c0\uac70\ub098 \ub3c5\uc131\uc744 \uac00\uc838 \ud65c\uc6a9\uc5d0 \ubd80\uc801\ud569\ud55c \uc0c1\ud669\uc774\ub2e4.<\/span><\/p>\n

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\ub450 \uac00\ub2e5\uc758 RNA\ub97c \uac00\uc9c4 \ubc14\uc774\ub7ec\uc2a4\uac00 \uce68\uc785\ud558\uba74 \uc138\ud3ec \ub0b4 RNA \uc808\ub2e8\ud6a8\uc18c\uc778 \ub2e4\uc774\uc11c\uac00 \ubc14\uc774\ub7ec\uc2a4 RNA\ub97c \uc808\ub2e8\ud574 \uc81c\uac70\ud558\uace0 \ubc14\uc774\ub7ec\uc2a4 \uc99d\uc2dd\uc744 \ub9c9\ub294\ub2e4. \uadf8 \ud6c4, \uc0dd\uba85\uccb4\uc5d0 \uc874\uc7ac\ud558\ub294 \ub9c8\uc774\ud06c\ub85cRNA\uac00 RNA\uac04\uc12d\uc744 \ud1b5\ud574 \uc720\uc804\uc790 \ubc1c\ud604\uc744 \uc5b5\uc81c\ud558\uace0, \ud0c0\uae43 \uc720\uc804\uc790(ex.\uc554 \ubc1c\uc0dd \uc720\uc804\uc790)\uc758 \ubc1c\ud604\uc744 \ub9c9\uc744 \uc218 \uc788\ub3c4\ub85d \ub514\uc790\uc778\ub41c \ub9de\ucda4\ud615 dsRNA\ub97c \uc8fc\uc785\ud558\uba74 \uc9c8\ubcd1 \uc720\ubc1c \uc720\uc804\uc790\uc758 mRNA\uc744 \ud30c\uad34\ud574 \uc9c8\ubcd1\uc744 \uce58\ub8cc\ud560 \uc218 \uc788\ub2e4. (\uc0ac\uc9c4 \ubc0f \ub0b4\uc6a9 : \ub514\ub77c\uc774\ube0c\ub7ec\ub9ac)<\/span><\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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RNA \uac04\uc12d \uce58\ub8cc\uc81c, \uc138\uacc4 \ucc98\uc74c\uc73c\ub85c \ud310\ub9e4 \ud5c8\uac00 \ubc1b\ub2e4<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uadf8\ub7f0\ub370 \uc9c0\ub09c\u00a08<\/span>\uc6d4\u00a010<\/span>\uc77c, RNA\u00a0<\/span>\uac04\uc12d \ud604\uc0c1\uc744 \uc774\uc6a9\ud55c \uc720\uc804 \uc9c8\ud658 \uce58\ub8cc\uc81c\uac00 \ucc98\uc74c\uc73c\ub85c \uc758\uc57d\ud488\uc73c\ub85c \uc778\uc815\ub418\uc5c8\ub2e4.\u00a0<\/span>\ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(FDA)<\/span>\uc774 \ucd5c\ucd08\ub85c\u00a0RNA\u00a0<\/span>\uac04\uc12d \uc758\uc57d\ud488\uc744 \uc2b9\uc778\ud55c \uac83. RNA\u00a0<\/span>\uac04\uc12d \ud604\uc0c1\uc774 \ubc1c\uacac\ub41c \uc9c0\u00a020<\/span>\ub144 \ub9cc\uc5d0 \uc774\ub8ec \ucf8c\uac70\ub2e4.\u00a0<\/span>\uc81c\ub300\ub85c \uc791\ub3d9\ud558\ub294 \uc57d\ubb3c \uc804\ub2ec \uc2dc\uc2a4\ud15c\uc774 \uac1c\ubc1c\ub41c \ub355\ubd84\uc774\ub2e4.<\/span>
\n\ubbf8\uad6d\uc2dd\ud488\uc758\uc57d\uad6d\uc774 \ud310\ub9e4 \uc2b9\uc778\uc744 \ub0b4\ub9b0 \uac83\uc740 \ubbf8\uad6d \ubc14\uc774\uc624\ubca4\ucc98\uae30\uc5c5 \uc568\ub098\uc774\ub78c \ud30c\ub9c8\uc288\ud2f0\uceec\uc988\uac00 \uac1c\ubc1c\ud55c \ud30c\ud2f0\uc2dc\ub780(patisiran.\u00a0<\/span>\uc81c\ud488\uba85\uc740 \uc628\ud30c\ud2b8\ub85c)<\/span>\uc774\ub2e4.\u00a0<\/span>\uc628\ud30c\ud2b8\ub85c\ub294 \ud76c\uc18c \uc2e0\uacbd \uc190\uc0c1 \uc9c8\ud658\uc778\u00a0\u2018<\/span>\uc720\uc804\uc131 \ud2b8\ub79c\uc2a4\ud2f0\ub808\ud2f4(transthyretin)\u00a0<\/span>\uc544\ubc00\ub85c\uc774\ub4dc\uc99d\u2019<\/span>\uc744 \uce58\ub8cc\ud558\ub294 \uc57d\ubb3c\uc774\ub2e4.\u00a0<\/span>\uc774 \uc9c8\ud658\uc740 \uae30\ud615 \ub2e8\ubc31\uc9c8\uc774 \uc2e0\uacbd\uc138\ud3ec\ub098 \uc2ec\uc7a5 \ub4f1 \uc5ec\ub7ec \uc7a5\uae30\uc5d0 \uc313\uc774\uba74\uc11c \ub9d0\ucd08\uc2e0\uacbd\ubcd1\uc99d\uc744 \uc720\ubc1c\ud55c\ub2e4.\u00a0<\/span>\uc804 \uc138\uacc4 \ud658\uc790 \uc218\ub294 \uc57d\u00a05<\/span>\ub9cc\uba85\uc73c\ub85c \ucd94\uc815\ub41c\ub2e4.\u00a0<\/span>\uc568\ub098\uc774\ub78c\uc740 \uace7 \uc720\ub7fd\uc5d0\uc11c\ub3c4 \uce58\ub8cc\uc81c\ub85c \ud5c8\uac00\ubc1b\uc744 \uc608\uc815\uc774\ub2e4.<\/span><\/p>\n

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\uc628\ud30c\ud2b8\ub85c\ub294 RNA\uac00 \ud2b8\ub79c\uc2a4\ud2f0\ub808\ud2f4 \ub2e8\ubc31\uc9c8\uc774 \ube44\uc815\uc0c1\uc801\uc73c\ub85c \uc0dd\uc131\ub418\ub294 \uacfc\uc815\uc5d0 \uac04\uc12d\ud558\ub3c4\ub85d \uc124\uacc4\ub410\ub2e4. RNA \uac04\uc12d\uae30\uc220\ub85c \uac1c\ubc1c\ub41c \uc138\uacc4 \ucd5c\ucd08\uc758 \uce58\ub8cc\uc81c\uc774\uba70, \uccb4\ub0b4\uc5d0 \uc8fc\uc0ac\ud558\ub294 \uac83\ub9cc\uc73c\ub85c \ud2b9\uc815 \uc720\uc804\uc790\ub97c \uad50\uc815\ud574 \uc9c8\ubcd1\uc744 \uce58\ub8cc\ud560 \uc218 \uc788\ub2e4. (\uc0ac\uc9c4 : \ud55c\uad6d\uacbd\uc81c)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\uc774\ubc88\uc5d0 \ud5c8\uac00\ub41c\u00a0RNA\u00a0<\/span>\uac04\uc12d \uc57d\ubb3c \ud30c\ud2f0\uc2dc\ub780\uc740 \ubcc0\uc774 \ud2b8\ub79c\uc2a4\ud2f0\ub808\ud2f4\uc758\u00a0mRNA<\/span>\ub97c \ud30c\uad34\ud574 \uc138\ud3ec \ub0b4\uc5d0 \ubcc0\uc774 \ud2b8\ub79c\uc2a4\ud2f0\ub808\ud2f4 \ub2e8\ubc31\uc9c8\uc774 \ucd95\uc801\ub418\uc9c0 \ubabb\ud558\uac8c \ub9cc\ub4e4\uc5b4 \uc57d\ud6a8\ub97c \ub0b8\ub2e4.\u00a0<\/span>\uc568\ub098\uc774\ub78c \ud30c\ub9c8\uc288\ud2f0\uceec\uc988\ub294 \uc591(+)<\/span>\uc804\ud558\ub97c \ub760\ub294 \uc9c0\uc9c8\ub098\ub178\ubd84\uc790\ub85c \uc74c(-)<\/span>\uc804\ud558\ub97c \ub760\ub294 \uc9e7\uc740\u00a0RNA\u00a0<\/span>\uc5fc\uae30\uac00\ub2e5\uc744 \uc774\uc911\uc73c\ub85c \uac10\uc2fc \ub4a4 \uc9c0\ub984\u00a050~100<\/span>\u339a\u00a0\ud06c\uae30\uc758 \ub098\ub178\uc785\uc790\ub85c \ub9cc\ub4e0 \uc57d\ubb3c \uc804\ub2ec \uc2dc\uc2a4\ud15c\uc744 \uc0ac\uc6a9\ud588\ub2e4.\u00a0<\/span>\uc9e7\uc740\u00a0RNA\u00a0<\/span>\uc5fc\uae30\uac00\ub2e5\uc774 \uac04\uc138\ud3ec\ub85c \uc774\ub3d9\ud558\uba74 \ud2b8\ub79c\uc2a4\ud2f0\ub808\ud2f4 \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4dc\ub294\u00a0mRNA<\/span>\uac00 \uc791\ub3d9\ud558\uc9c0 \ubabb\ud574 \uac04\uc12d\uc774 \uc77c\uc5b4\ub098\ub294 \uc6d0\ub9ac\ub85c \uc791\ub3d9\ud55c\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\ud30c\ud2f0\uc2dc\ub780 \uc57d\ubb3c\uc740\u00a03<\/span>\uc8fc \uac04\uaca9\uc73c\ub85c\u00a01<\/span>\ub144\uac04 \ud22c\uc57d\ud558\ub294 \ub370\u00a0\uce58\ub8cc\ube44\uac00 \ubb34\ub824\u00a035<\/span>\ub9cc \ub2ec\ub7ec(<\/span>\uc57d\u00a04<\/span>\uc5b5 \uc6d0).\u00a0<\/span>\uc5b4\ub9c8\uc5b4\ub9c8\ud55c \uac00\uaca9\uc778 \ub9cc\ud07c \uc18c\uc218\uc758 \ud658\uc790\ub97c \uc704\ud55c \uc81c\ub3c4\uc801\uc778 \ubc29\uc548\ub3c4 \ub9c8\ub828\ub3c4 \ud544\uc694\ud558\ub2e4.\u00a0<\/span>\ud604\uc7ac \uc568\ub098\uc774\ub78c\uc740\u00a010<\/span>\uc5ec \uac00\uc9c0\uc758 \ub2e4\ub978\u00a0RNA\u00a0<\/span>\uac04\uc12d \uc57d\ubb3c \uc784\uc0c1\uc744 \uc9c4\ud589 \uc911\uc774\uace0,\u00a0<\/span>\uad6d\ub0b4\uc678 \uc5ec\ub7ec \uc5c5\uccb4\uc5d0\uc11c\ub3c4 \uc57d\ubb3c\uc774 \ub098\uc624\uae30\u00a0\uc2dc\uc791\ud558\uace0 \uc788\uc5b4 \uc81c\uc870\uc2dc\uc2a4\ud15c\uc774 \ucd5c\uc801\ud654\ub418\uba74 \uac12\uc740 \ube60\ub974\uac8c \ub5a8\uc5b4\uc9c8 \uac83\uc73c\ub85c \ubcf4\uc778\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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RNA\u00a0<\/span>\uac04\uc12d \ub18d\uc57d\ub3c4 \ucd9c\uc2dc\uac00 \uba38\uc9c0\uc54a\uc558\ub2e4. RNA\u00a0<\/span>\uac04\uc12d \uae30\uc220\uc740 \ud2b9\uc815 \uc2dd\ubb3c \uc720\uc804\uc790\ub97c \uc5b5\uc81c\ud55c \ub4a4,\u00a0<\/span>\uae30\ub2a5\uc744 \uaddc\uba85\ud568\uc73c\ub85c\uc368 \ubcd1\ucda9\ud574 \uc608\ubc29\uc774 \uac00\ub2a5\ud55c \uc0c8\ub85c\uc6b4 \ud488\uc885\uc744 \uac1c\ubc1c\ud560 \uc218 \uc788\ub2e4. RNA\u00a0<\/span>\uac04\uc12d\uc774 \uc758\ud559\uacfc \ub18d\uc5c5\uc5d0 \uc5bc\ub9c8\ub098 \ud070 \ud30c\uc7a5\uc744 \ubd88\ub7ec\uc77c\uc73c\ud0ac\uc9c0 \uae30\ub300\uac00 \ud06c\ub2e4.\u00a0<\/span><\/p>\n

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IBS RNA \uc5f0\uad6c\ub2e8, \ucd08\uae30 \ubc30\uc544\uc5d0\uc11c miRNA \uc870\uc808 \ud604\uc0c1 \ucd5c\ucd08 \uaddc\uba85<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc6b0\ub9ac\ub098\ub77c\uc758 \uae30\ucd08\uacfc\ud559\uc5f0\uad6c\uc6d0(IBS) RNA\u00a0<\/span>\uc5f0\uad6c\ub2e8 \uae40\ube5b\ub0b4\ub9ac \ub2e8\uc7a5(<\/span>\uc11c\uc6b8\ub300 \uc0dd\uba85\uacfc\ud559\ubd80 \uc11d\uc88c\uad50\uc218)\u00a0<\/span>\uc5f0\uad6c\ud300\ub3c4\u00a0RNA\u00a0<\/span>\uac04\uc12d\uc5d0 \ub300\ud55c \uc138\uacc4\uc801 \uc5f0\uad6c \uc131\uacfc\ub97c \ub0b4\uace0 \uc788\ub2e4. 2104<\/span>\ub144\uacfc\u00a02015<\/span>\ub144\uc5d0\ub294\u00a0RNA<\/span>\uc640\u00a0miRNA\u00a0<\/span>\uad00\ub828 \uc5f0\uad6c \uc131\uacfc\ub97c \uc787\ub2ec\uc544 \ubc1c\ud45c\ud574 \uad6d\ub0b4\uc678 \ud559\uacc4\uc758 \ud070 \uc8fc\ubaa9\uc744 \ubc1b\uc558\ub2e4.\u00a0<\/span><\/p>\n

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IBS \uc5f0\uadc4\uc740 \ucd08\uae30 \ubc30\uc544\uc11c \uc77c\uc5b4\ub098\ub294 miRNA \uc870\uc808 \uae30\uc804\uc744 \ubc1d\ud614\ub2e4. \uc5f0\uad6c\uc5d0 \ub530\ub974\uba74 \ubaa8\uccb4\ub85c\ubd80\ud130 \uc720\ub798\ud55c miRNA\ub294 \uc704\uc2a4\ud53c(Wisp)\uc5d0 \uc758\ud574 \ubd84\ud574\ub418\uba74\uc11c \uc591\uc774 \uac10\uc18c\ud55c\ub2e4. (\ucd9c\ucc98: IBS)<\/span><\/span><\/div>\n<\/div>\n

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\uc5f0\uad6c\ud300\uc758 \uccab \ubc88\uc9f8 \uc5f0\uad6c \uc131\uacfc\ub294\u00a0<\/span>miRNA<\/i>\uac00 \ucd08\uae30 \ubc30\uc544\uc5d0\uc11c \uc870\uc808\ub418\ub294 \ud604\uc0c1\uc744 \uc138\uacc4 \ucd5c\ucd08\ub85c \ubc1d\ud600\ub0b8 \uac83\uc774\ub2e4<\/i>.<\/i><\/span>miRNA\ub294 \ud2b9\uc815 \ub2e8\ubc31\uc9c8\uc774 \uacfc\ub3c4\ud558\uac70\ub098 \ubd80\uc871\ud558\uc9c0 \uc54a\ub3c4\ub85d \ub2e8\ubc31\uc9c8\uc758 \ubc1c\ud604\uc744 \uc81c\uc5b4\ud558\ub294 \uae30\ub2a5\uc744 \uac16\uace0 \uc788\ub2e4.\u00a0\ucd08\uae30 \ubc30\uc544\uc5d0\uc11c\ub294\u00a0RNA\uac00 \ub2e8\ubc31\uc9c8 \ubc1c\ud604\uc744 \uc870\uc808\ud558\ub294 \uacbd\uc6b0\uac00 \ub9ce\ub2e4.\u00a0\uc774 \uc2dc\uae30\uc5d0\ub294 \uc218\uc815\ub780\uc758\u00a0miRNA\uac00 \ud569\uc131\ub418\uae30 \uc804\uc73c\ub85c,\u00a0\ubaa8\uccb4(\ub09c\uc790)\uc758\u00a0RNA\uac00 \ub2e8\ubc31\uc9c8 \ubc1c\ud604 \uc5ed\ud560\uc744 \ub300\uc2e0\ud55c\ub2e4.\u00a0\uc5f0\uad6c\ud300\uc740 \ubaa8\uccb4\uc5d0 \uc788\ub294\u00a0miRNA\u00a0\ub05d\ubd80\ubd84\uc5d0 \uc5fc\uae30\uc758 \ud55c \uc885\ub958\uc778 \uc544\ub370\ub2cc(A)\u00a0\uaf2c\ub9ac\uac00 \ubd99\ub294\ub2e4\ub294 \uc0ac\uc2e4\uacfc,\u00a0\uc774\ub7ec\ud55c \ubcc0\ud615\uc73c\ub85c\u00a0miRNA\uc758 \uc591\uc774 \uc870\uc808\ub41c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ud655\uc778\ud588\ub2e4.<\/span><\/span><\/span><\/p>\n

\ub610\ud55c \ucd08\ud30c\ub9ac \uc2e4\ud5d8\uc73c\ub85c\u00a0miRNA<\/span>\uc5d0 \uc544\ub370\ub2cc \uaf2c\ub9ac\ub97c \ub2ec\uc544\uc8fc\ub294 \uac83\uc740\u00a0\u2018<\/span>\uc704\uc2a4\ud53c(Wispy)\u2019\u00a0<\/span>\ud6a8\uc18c\ub77c\ub294 \uc810\ub3c4 \uc54c\uc544\ub0c8\ub2e4.\u00a0<\/span>\uc9c0\uae08\uae4c\uc9c0 \uc54c\ub824\uc9c0\uc9c0 \uc54a\uc558\ub358 \ucd08\uae30 \ubc30\uc544 \ub2e8\uacc4\uc758 \uc911\uc694\ud55c \uc0dd\uba85\ud604\uc0c1\uc744 \uc0c8\ub86d\uac8c \ubc1d\ud600\ub0b8 \uac83\uc774\ub2e4.\u00a0<\/span>\uc131\uacfc\ub294\u00a0\u2018<\/span>\ubab0\ub808\ud058\ub7ec \uc140\u2019<\/span>\uc5d0 \uc2e4\ub838\ub2e4.
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\n<\/span>\ub610 \ud558\ub098\uc758 \uc5f0\uad6c \uc131\uacfc\ub294\u00a0<\/span>miRNA<\/i>\ub97c \ub9cc\ub4dc\ub294 \ub2e8\ubc31\uc9c8 \ubcf5\ud569\uccb4\uc758 \uad6c\uc131\uacfc \uae30\ub2a5\uc744 \ubc1d\ud600\u00a0<\/i>miRNA\u00a0<\/i>\ud0c4\uc0dd\uc758 \ube44\ubc00\uc744 \uaddc\uba85\ud55c \uac83<\/i><\/span>\uc774\ub2e4.\u00a0\uc5f0\uad6c\ud300\uc740 \uc77c\uba85\u00a0\u2018\ub9c8\uc774\ud06c\ub85c\ud504\ub85c\uc138\uc11c\u2019\ub85c \ubd88\ub9ac\ub294\u00a0\u2018\ub4dc\ub85c\uc154-DGCR8\u2019\u00a0\ub2e8\ubc31\uc9c8 \ubcf5\ud569\uccb4\uac00\u00a01\uac1c\uc758 \ub4dc\ub85c\uc154(Drosha,\u00a0\ud6a8\uc18c)\u00a0\ubd84\uc790\uc640\u00a02\uac1c\uc758\u00a0DGCR8\u00a0\ubd84\uc790\ub85c \uad6c\uc131\ub3fc \uc788\ub2e4\ub294 \uac83\uc744 \ud30c\uc545\ud588\ub2e4.\u00a0<\/span><\/p>\n

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\ub9c8\uc774\ud06c\ub85c\ud504\ub85c\uc138\uc11c\ub294 \ud55c \ubd84\uc790\uc758 \ub4dc\ub85c\uc154\uc640 \ub450 \ubd84\uc790\uc758 DGCR8\uc73c\ub85c \uad6c\uc131\ub41c\ub2e4. \ub4dc\ub85c\uc154\ub294 RNA\ub97c \uc790\ub974\ub294 \ud6a8\uc18c \uc5ed\ud560 \ubfd0 \uc544\ub2c8\ub77c \ud558\ub2e8\ubd84\uae30\uc810\uc744 \uc778\uc2dd\ud558\uc5ec \uc808\ub2e8\ud560 \uc704\uce58\ub97c \uce21\uc815\ud558\ub294 \uac00\ub2a0\uc790 \uc5ed\ud560\ub3c4 \uc218\ud589\ud55c\ub2e4. DGCR8\uc740 \ub4dc\ub85c\uc154\ub97c \uc548\uc815\ud654\uc2dc\ud0a4\ub294 \uc5ed\ud560\uc744 \uc218\ud589\ud558\uace0 \ub610\ud55c \uc0c1\ub2e8\ubd84\uae30\uc810\uc744 \uc778\uc2dd\ud558\uc5ec miRNA 1\ucc28 \uc804\uad6c\uccb4(pri-miRNA)\uc758 \uc808\ub2e8 \ud6a8\uc728\uc744 \ub192\uc5ec\uc900\ub2e4. (\ucd9c\ucc98:IBS)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\ub610\ud55c \ub4dc\ub85c\uc154 \ubd84\uc790\uac00\u00a0miRNA\uc758 \ucd08\uae30 \uc804\uad6c\uccb4(DNA\uc5d0\uc11c \uc804\uc0ac\ub41c \ub35c \uc131\uc219\ud55c\u00a0miRNA)\ub97c \uc778\uc9c0\ud574 \uc808\ub2e8\ud560 \uc704\uce58\ub97c \ucc3e\uc544\uac00 \uc790\ub974\uace0,\u00a0\ub4dc\ub85c\uc154\uc758 \ud30c\ud2b8\ub108\uc778\u00a0DGCR8\u00a0\ubd84\uc790\ub294 \uc815\ud655\ud55c \uc808\ub2e8 \ubd80\uc704\ub97c \ucc3e\ub3c4\ub85d \ub3c4\uc640\uc8fc\ub294 \uae30\ub2a5\uc744 \ud55c\ub2e4\ub294 \uac83\uc744 \ud655\uc778\ud588\ub2e4.\u00a0\uc774 \uc5f0\uad6c\ub294 \ub4dc\ub85c\uc154 \ub2e8\ubc31\uc9c8\uc758 \uae30\ub2a5\uc744 \ud574\ubd80\ud558\uc5ec \ud559\uacc4 \ub17c\ub780\uc744 \uae54\ub054\ud558\uac8c \uc815\ub9ac\ud588\ub2e4\ub294 \ub370 \ud070 \uc758\uc758\uac00 \uc788\ub2e4.<\/span><\/p>\n

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miRNA\ub85c \uc138\ud3ec\ubd84\uc5f4 \ubc29\ud574\ud574 \uc554 \uc5b5\uc81c\ud55c\ub2e4<\/p><\/blockquote>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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IBS RNA\u00a0<\/span>\uc5f0\uad6c\ud300\uc740\u00a0miRNA<\/span>\ub97c \uc774\uc6a9\ud574 \uc554\uc744 \uce58\ub8cc\ud558\ub294 \ubc29\ubc95\uc744 \uc5f0\uad6c \uc911\uc774\ub2e4.\u00a0<\/span>\uc5f0\uad6c\ub2e8\uc774 \uc8fc\ubaa9\ud558\uace0 \uc788\ub294 \uc720\uc804\uc790\ub294 \uc554\uc744 \uc5b5\uc81c\ud558\ub294 \ub370 \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ud558\ub294 \uc720\uc804\uc790\u00a0let-7. let-7 miRNA<\/span>\ub294 \uc138\ud3ec\ubd84\uc5f4\uc744 \ubc29\ud574\ud574 \uc99d\uc2dd\ud558\uc9c0 \ubabb\ud558\uac8c \ub9c9\ub294 \ubc29\ubc95\uc73c\ub85c \uc554\uc744 \uc5b5\uc81c\ud55c\ub2e4.\u00a0<\/span>\ub530\ub77c\uc11c\u00a0let-7 miRNA<\/span>\uac00 \uc801\uac8c \ub9cc\ub4e4\uc5b4\uc9c4\ub2e4\uba74 \uc138\ud3ec\ubd84\uc5f4\uc774 \uae09\uaca9\ud788 \uc99d\uac00\ud574 \uc554\uc774 \uc0dd\uae34\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc5f0\uad6c\ud300\uc740 \uc904\uae30\uc138\ud3ec\uc640 \uac04\uc554\uc138\ud3ec\uc5d0\uc11c\u00a0let-7\u00a0<\/span>\uc720\uc804\uc790\uac00 \uc791\uc6a9\ud574\u00a0miRNA<\/span>\uac00 \ub9cc\ub4e4\uc5b4\uc9c0\ub294 \uacfc\uc815\uc744 \uc5f0\uad6c\ud588\ub2e4.\u00a0<\/span>\uc904\uae30\uc138\ud3ec\uc640 \uc554\uc138\ud3ec\ub97c \uc774\uc6a9\ud55c \uc774\uc720\ub294 \ub450 \uc138\ud3ec\uac00 \ub04a\uc784\uc5c6\uc774 \ubd84\uc5f4\ud558\ub294 \ubc29\uc2dd\uc774 \ube44\uc2b7\ud558\uae30 \ub54c\ubb38.\u00a0<\/span>\uc5f0\uad6c\ud300\uc740 \uac04\uc554\uc138\ud3ec\uc5d0\uc11c \ub9ce\uc774 \ubc1c\uacac\ub41c\ub2e4\uace0 \uc54c\ub824\uc9c4 \ub2e8\ubc31\uc9c8\u00a0Lin28<\/span>\uc774 \ub35c \uc131\uc219\ud55c\u00a0let-7 miRNA<\/span>\uc640 \ubcf5\ud569\uccb4\ub97c \uc774\ub8ec\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc54c\uc544\ub0c8\ub2e4.\u00a0<\/span>miRNA\u00a0<\/span>\ubaa8\uc591\uc744 \ubc14\uafb8\ub294 \ud6a8\uc18c\u00a0TUT4<\/span>\ub97c \ubc1c\uacac\ud558\ub294 \uc131\uacfc\ub3c4 \uc62c\ub838\ub2e4. TUT4<\/span>\ub294\u00a0Lin28<\/span>\uacfc \ubcf5\ud569\uccb4\ub97c \uc774\ub8e8\uace0 \uc788\ub294 \ub35c \uc131\uc219\ud55c\u00a0let-7 miRNA<\/span>\uc744 \uc778\uc9c0\ud574 \ub05d\ubd80\ubd84\uc5d0 \uc6b0\ub77c\uc2e4 \uc57d\u00a014<\/span>\uac1c\ub97c \uaf2c\ub9ac\ucc98\ub7fc \ub2ec\uc544\uc900\ub2e4.\u00a0<\/span>\ubaa8\uc591\uc774 \ubc14\ub010\u00a0let-7 miRNA<\/span>\ub294 \ud575\uc0b0 \ubd84\ud574\ud6a8\uc18c\uc5d0 \uc758\ud574 \uc798\ub9b0\ub2e4.\u00a0<\/span>\uc5f0\uad6c\uc9c4\uc740\u00a0let-7<\/span>\uc774 \uac10\uc18c\ud558\uba74 \uc138\ud3ec\ub294 \ubd84\uc5f4\uc744 \uba48\ucd94\uc9c0 \ubabb\ud574 \uc554\uc138\ud3ec\ucc98\ub7fc \ub04a\uc784\uc5c6\uc774 \uc99d\uc2dd\ud568\uc744 \ud655\uc778\ud588\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\uc804\ubb38\uac00\ub4e4\uc740\u00a0miRNA<\/span>\ub97c \uc778\uacf5\uc801\uc73c\ub85c \ub9cc\ub4e0 \ub4a4 \uc138\ud3ec \uc548\uc5d0 \ub123\uc73c\uba74 \uc9c8\ubcd1\uc744 \uce58\ub8cc\ud560 \uc218 \uc788\ub2e4\uace0 \ub9d0\ud55c\ub2e4.\u00a0<\/span>\ud2b9\ubcc4\ud55c \ubaa9\uc801\uc73c\ub85c \ub9cc\ub4e4\uc5b4\uc9c4 \uc778\uacf5\u00a0miRNA<\/span>\uac00 \ud45c\uc801\uc778\u00a0RNA<\/span>\uc758 \ud2b9\uc815 \ubd80\uc704\uc5d0\ub9cc \uacb0\ud569\ud574 \uc9c8\ubcd1\uc744 \uc720\ubc1c\ud558\ub294 \uc720\uc804\uc790 \ubc1c\ud604\uc744 \uc5b5\uc81c\ud55c\ub2e4\uba74\u00a0\ubc1c\ubcd1 \uc790\uccb4\ub97c \uc5b5\uc81c\ud560 \uc218 \uc788\uae30 \ub54c\ubb38\uc774\ub2e4.\u00a0<\/span>\uc778\uacf5\u00a0miRNA<\/span>\ub97c \uc774\uc6a9\ud55c \uce58\ub8cc\ubc95\uc740 \uc544\uc9c1\uae4c\uc9c0\ub294 \uc2e4\ud5d8 \ub2e8\uacc4\uc5d0 \uba38\ubb3c\ub7ec \uc788\ub2e4.<\/span><\/p>\n

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\uc720\uc804\uc790 \ubc1c\ud604\uc744 \uc870\uc808\ud558\ub294 \uc544\uc8fc \uc791\uc740 RNA, miRNA\uc5d0 \uacfc\ud559\uacc4\uac00 \uac70\ub294 \uae30\ub300\uac00 \ud06c\ub2e4. \uacfc\uc5f0 \uc720\uc804\uc790 \uce58\ub8cc\uc81c \uac1c\ubc1c\uc758 \ud575\uc2ec\uc774 \ub420 \uc218 \uc788\uc744\uc9c0, \uc55e\uc73c\ub85c\uc758 \uc5f0\uad6c\uac00 \uae30\ub300\ub41c\ub2e4. (\ucd9c\ucc98: \uad6c\uae00)<\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\uc0dd\uba85\uacfc\ud559\uacc4\uc5d0\uc11c\ub294\u00a0miRNA<\/span>\uac00 \ubd88\uce58\ubcd1\uc744 \uce58\ub8cc\ud558\ub294 \uc5f4\uc1e0\uac00 \ub420 \uac83\uc73c\ub85c \uae30\ub300\ud55c\ub2e4.\u00a0<\/span>\uc774\ubbf8 \uc2dc\uc791\ub41c \uc9c8\ud658\uc758 \uc99d\uc0c1\uc744 \uc644\ud654\ud558\uac70\ub098 \ubab8\uc18d\uc5d0 \uc788\ub294 \uc9c8\ubcd1\uc778\uc790\ub97c \uc5c6\uc560\ub294 \uce58\ub8cc\uac00 \uc544\ub2c8\ub77c\u00a0miRNA<\/span>\ub97c \uc99d\uac00\uc2dc\ud0a4\uac70\ub098 \uac10\uc18c\uc2dc\ucf1c \uc720\uc804\uc790\uac00 \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4dc\ub294 \uc815\ub3c4\ub97c \uc5b5\uc81c\ud558\uba74 \ub41c\ub2e4\ub294 \uc0dd\uac01\uc5d0\uc11c\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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\ub274\ud074\ub808\uc624\ud2f0\ub4dc\u00a022<\/span>\uac1c \uc815\ub3c4\ub85c \uad6c\uc131\ub41c \uc791\uc740 \ud06c\uae30\uc5d0\ub3c4 \ubd88\uad6c\ud558\uace0 \uc138\ud3ec \ub0b4\uc5d0\uc11c \uc911\uc694\ud55c \uc5ed\ud560\uc744 \ub9e1\uace0 \uc788\ub294\u00a0miRNA<\/span>\uc640,\u00a0<\/span>\uc791\uace0 \uc18c\ubc15\ud55c \uafc8\uc744 \ud558\ub098\uc529 \uc774\ub8e8\uba74\uc11c \uc5b8\uc820\uac00\ub294 \ud55c\uad6d \uacfc\ud559\uc5d0 \uae30\uc5ec\ud558\uace0 \uc2f6\ub2e4\ub294 \uae40\ube5b\ub0b4\ub9ac \ub2e8\uc7a5 \uc5f0\uad6c\ud300\uc740 \uc5b4\ub518\uac00 \ub2ee\uc740 \ub4ef\ud558\ub2e4.\u00a0<\/span>\uc5f0\uad6c\ud300\uc744 \ud1b5\ud574\u00a0miRNA<\/span>\ub97c \uc774\uc6a9\ud55c \uc548\uc804\ud55c \uc57d\ubb3c\ub4e4\uc774 \uac1c\ubc1c\ub3fc \ubd88\uce58\ubcd1\uc744 \ud574\uacb0\ud558\ub294 \ub370 \ud55c \uac78\uc74c \ub098\uc544\uac00\uae38 \uae30\ub300\ud55c\ub2e4.<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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http:\/\/dongascience.donga.com\/news\/view\/22644<\/p>\n

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Science<\/span>\u00a0\uc81c\uacf5<\/em><\/span><\/p>\n

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\ubc1c\ub2ec\uc0dd\ubb3c\ud559\uc5d0\uc11c \uc2e0\uacbd \ubc1c\ub2ec\uc744 \uc704\ud55c \uae30\ucd08 \uc5f0\uad6c\ub294 \uc608\uc05c\uaf2c\ub9c8\uc120\ucda9(Caenorhabditis<\/span>elegans<\/span>), \uc7a5\uae30 \ubc1c\ub2ec \uc5f0\uad6c\ub294 \uc81c\ube0c\ub77c\ud53c\uc26c(Danio<\/span>\u00a0rerio<\/span>)\ub97c \uc0ac\uc6a9\ud574 \uc9c4\ud589\ud55c\ub2e4. \uc774 \ubd84\uc57c \ud559\uc790\ub4e4\uc774 \uc2e4\ud5d8\uc744 \uc124\uacc4\ud560 \ub54c \uc5fc\ub450\uc5d0 \ub450\ub294 \uae30\ubcf8 \uacf5\uc2dd\uc774\ub2e4.<\/p>\n

\uc608\uc05c\uaf2c\ub9c8\uc120\ucda9\uc774 \uac00\uc9c4 \uc57d 300\uc5ec \uac1c \uc2e0\uacbd\uc138\ud3ec\uc640 8000\uc5ec \uac1c \uc2e0\uacbd\uc5f0\uacb0\ub9dd\uc758 \uc0c1\ud638\uc791\uc6a9\uc774 \uc774\ubbf8 20\uc5ec\ub144 \uac04\uc758 \uc5f0\uad6c \ub05d\uc5d0 \ubaa8\ub450 \ubc1d\ud600\uc838 \uc788\uc5b4 \uc2e0\uacbd \ubc1c\ub2ec \uc5f0\uad6c\uc5d0 \ub110\ub9ac \ud65c\uc6a9\ub418\uace0 \uc788\ub2e4. \uc81c\ube0c\ub77c\ud53c\uc26c\ub294 \uc778\uac04\uc774 \uc9c0\ub2cc \uc2ec\uc7a5\uc774\ub098 \uac04, \ucdcc\uc7a5, \uc2e0\uc7a5, \ud749\uc120 \ub4f1 \ub300\ubd80\ubd84\uc758 \uc7a5\uae30\ub97c \uac00\uc9c0\uace0 \uc788\ub294\ub370\ub2e4 \uc720\uc804\uc790\uac00 \uc57d 70% \uac00\ub7c9 \uc778\uac04\uacfc \ub3d9\uc77c\ud55c \uac83\uc73c\ub85c \uc54c\ub824\uc84c\ub2e4.<\/p>\n

\uc774\ub7f0 \ub3d9\ubb3c\uc744 \ud1b5\ud574 \uae30\ubcf8 \uc2dc\uc2a4\ud15c\uc744 \uc774\ud574\ud55c \ub4a4 \uc774\ubcf4\ub2e4 \ud6e8\uc52c \ubcf5\uc7a1\ud55c \uc778\uac04\uc758 \ubc1c\ub2ec \uacfc\uc815\uc744 \ubc1d\ud788\uaca0\ub2e4\ub294 \uc804\ub7b5\uc774\ub2e4. 5\uc6d4\uc758 \ub9c8\uc9c0\ub9c9 \ub0a0 (31\uc77c \ud604\uc9c0\uc2dc\uac01) \ub098\uc628 \ud559\uc220\uc9c0 \u2018\uc0ac\uc774\uc5b8\uc2a4\u2019\uc758 \ud45c\uc9c0\ub294 \uac01\uc885 \ud615\uad11\uc744 \ub764 \uc138\ud3ec\ub4e4\ub85c \ub098\ud0c0\ub0b8 \uc81c\ube0c\ub77c\ud53c\uc26c\uac00 \ucc28\uc9c0\ud588\ub2e4.<\/p>\n

\uc774\ubc88 \ud638\uc5d0\ub294 \ub300\ud45c\uc801 \uc2e4\ud5d8\ub3d9\ubb3c\uc778 \uc81c\ud504\ub77c\ud53c\uc26c\ub098 \uc544\ud504\ub9ac\uce74\ubc1c\ud1b1\uac1c\uad6c\ub9ac(Xenopus<\/span>\u00a0laevis<\/span>)\uc758 \uc218\uc815\ub780 (\ubc30\uc544) \uc138\ud3ec\uac00 \ud2b9\uc815 \uc7a5\uae30 \uc138\ud3ec\ub85c \uacb0\uc815\ub418\ub294 \uacfc\uc815\uc744 \ubc1d\ud78c \ubbf8\uad6d \ud558\ubc84\ub4dc\uc758\ub300 \uc5f0\uad6c\ud300\uc758 \ub17c\ubb38 2\ud3b8\uc774 \ubc1c\ud45c\ub410\ub2e4. \uc774\uc5d0 \ub300\ud574 \ubc84\ud074\ub9ac\ub300 \uc0dd\uba74\uacfc\ud559\uacfc \ub9ac\ucc98\ub4dc \ud558\ub79c\ub4dc \uad50\uc218\uac00 \uc4f4 \u2018\ubc30\uc544\uc758 \ubc1c\ub2ec\uacfc \uc7ac\uc99d\uc2dd\uc5d0 \ub300\ud55c \uc0c8\ub85c\uc6b4 \uad00\uc810\u2019\uc774\ub780 \ub9ac\ubdf0\ub17c\ubb38 1\ud3b8\ub3c4 \ud568\uaed8 \uc2e4\ub838\ub2e4.<\/p>\n

\ucd08\uae30 \ubc30\uc544\uc758 \ubc1c\ub2ec \uacfc\uc815\uc744 \ubc1d\ud788\uae30 \uc704\ud574 \ube7c\ub193\uc744 \uc218 \uc5c6\ub294 \uac83\uc774 \ubc30\uc544\uc758 \uc6b4\uba85\uc744 \uacb0\uc815\uc9d3\ub294\ub370 \uad00\uc5ec\ud558\ub294\u00a0RNA<\/span>\u00a0\uc804\uc0ac\uccb4\ub2e4. \uc81c\ube0c\ub77c\ud53c\uc26c\uc758 \uacbd\uc6b0 \uc218\ub9cc \uac1c\ub85c \uc54c\ub824\uc838 \uc788\uc73c\uba70, \uace0\ub4f1\ub3d9\ubb3c\ub85c \uac08\uc218\ub85d \uc804\uc0ac\uccb4\uc758 \uc218\ub294 \uae30\ud558\uae09\uc218\uc801\uc73c\ub85c \uc99d\uac00\ud55c\ub2e4.<\/p>\n

\uc774\ub4e4\uc758 \uc804\uccb4\uc801 \uc0c1\ud638\uc791\uc6a9 \uacfc\uc815\uc744 \ucd94\uc801\ud558\uae30 \uc704\ud574 \ubbf8\uad6d \ud558\ubc84\ub4dc\uc758\ub300 \uc2dc\uc2a4\ud15c\uc0dd\ubb3c\ud559\uacfc \ub2e4\ub2c8\uc5d8 \uc640\uadf8\ub108 \ubc15\uc0ac\ud300\uc740 \uc81c\ube0c\ub77c\ud53c\uc26c\uc758 \ubc30\uc544 \uc18d\u00a0RNA<\/span>\u00a0\uc804\uc0ac\uccb4\uc758 \uc5fc\uae30\ub97c \ubd84\uc11d\ud588\ub2e4. \uadf8 \uc5fc\uae30 \ubcc0\ud654 \uc815\ubcf4\ub97c \uc785\ub825\ud574 \ucef4\ud4e8\ud130 \ud504\ub85c\uadf8\ub798\ubc0d\uc73c\ub85c \ubd84\uc11d\ud55c \uacb0\uacfc, \ud558\ub098\uc758 \uc81c\ube0c\ub77c\ud53c\uc26c \ubc30\uc544\uc5d0\uc11c \uc57d 9\ub9cc 2000\uc5ec \uac1c\uc758 \uc81c\ube0c\ub77c\ud53c\uc26c \uc804\uc0ac\uccb4\uac00 \uc791\uc6a9\ud568\uc744 \ubc1c\uacac\ud588\ub2e4. \uc774\ub4e4\uc758 \uc791\uc6a9\uc744 \uac70\uccd0 25 \uac00\uc9c0 \uc885\ub958\uc758 \ud2b9\uc815 \uc7a5\uae30 \uc138\ud3ec\ub85c \uc6b4\uba85\uc774 \uacb0\uc815\ub418\ub294 \uacfc\uc815\uc744 \ub098\ubb34\uc5d0\uc11c \uac00\uc9c0\uac00 \ud37c\uc9c0\ub294 \uac83\ucc98\ub7fc \ubaa8\uc2dd\ub3c4\ub85c \uc791\uc131\ud558\ub294\ub370 \uc131\uacf5\ud588\ub2e4.<\/p>\n

 <\/p>\n

<\/span><\/p>\n

\uc81c\ud504\ub77c\ud53c\uc26c \ubc30\uc544\uac00 \ubd84\uc5f4\ud558\ub294 \uccab\ub0a0 \ub098\ud0c0\ub098\ub294\u00a0RNA<\/span>\u00a0\uc804\uc0ac\uccb4\ub4e4\uc758 \ubcc0\ud654\uacfc\uc815\uc744 \uc2dc\uac01\uc801\uc73c\ub85c \ub098\ud0c0\ub0c8\ub2e4. \ube68\uac04\uac83\uc77c\uc218\ub85d \uc2e0\uacbd\uacfc \uad00\ub828\ub41c \uc804\uc0ac\uccb4, \ud30c\ub780\uac83\uc77c\uc218\ub85d \uc0c1\ud53c\uc870\uc9c1, \ucd08\ub85d\uc0dd\uc744 \uc911\ub0b4\ubc30\uc5fd\uacfc \uad00\ub828\ub41c \uc804\uc0ac\uccb4\ub4e4\uc758 \uc5f0\uacb0\uc131\uc744 \ub098\ud0c0\ub0b8\ub2e4. –science<\/span>\u00a0\uc81c\uacf5<\/em><\/span><\/p>\n

 <\/p>\n

\uc640\uadf8\ub108 \ubc15\uc0ac\uc640 \uac19\uc740 \uacfc\uc5d0 \uc18d\ud55c \uc81c\uc784\uc2a4 \ube0c\ub9ad \ubc15\uc0ac\ub294 \ub610 \ub2e4\ub978 \uc8fc\uc694 \uc2e4\ud5d8\ub3d9\ubb3c\uc778 \uc544\ud504\ub9ac\uce74\ubc1c\ud1b1\uac1c\uad6c\ub9ac\uc758 13\ub9cc 7000\uac1c\uc758 \uc804\uc0ac\uccb4\uac00 \uc791\uc6a9\ud574 69 \uc885\ub958\uc758 \uc138\ud3ec\ub85c \uacb0\uc815\ub418\ub294 \uacfc\uc815\ub3c4 \ud655\uc778\ud574 \ub17c\ubb38\uc744 \uc2e4\uc5c8\ub2e4.<\/p>\n

\uc640\uadf8\ub108 \uad50\uc218\ub294 \ub17c\ubb38\uc5d0\uc11c \u201c\ubd84\ud654\ub2a5\uc744 \uac00\uc9c0\uace0 \uc788\ub358 \ubc30\uc544\uc138\ud3ec\uac00 \uac01\uac01\uc758 \uc131\uc219\ud55c \uc138\ud3ec\ub85c \uacb0\uc815\ub418\ub294 \uacfc\uc815\uc744 \uc774\ud574\ud558\ub294 \uac8c \ubc1c\uc0dd\ud559\uc774 \ucd94\uad6c\ud558\ub294 \ubaa9\ud45c\u201d\ub77c\uba70 \u201c(\uc0c8\ub85c\uc6b4 \ubd84\uc11d\ubc95\uc73c\ub85c)\u00a0RNA<\/span>\u00a0\uc804\uc0ac\uccb4 \ub370\uc774\ud130\ub97c \ubd84\uc11d\ud574 \uc804\uccb4 \ubc30\uc544\uc138\ud3ec \uac04 \uc720\uc804\uc790 \ubcc0\ud654\uc640 \ubc1c\ud604 \ud750\ub984\uc744 \ud30c\uc545\ud558\uba74 \ud5a5\ud6c4 \uace0\ub4f1\uc0dd\ubb3c\uc758 \ubc1c\ub2ec \uacfc\uc815\uc744 \uc774\ud574\ud558\ub294 \ub370 \ub3c4\uc6c0\uc774 \ub420 \uac83\u201d\uc774\ub77c\uace0 \ub9d0\ud588\ub2e4.<\/p>\n

\ub9ac\ucc98\ub4dc \ud558\ub79c\ub4dc \uad50\uc218\ub294 \ub9ac\ubdf0 \ub17c\ubb38\uc744 \ud1b5\ud574 \u201c\uac01\uac01\uc758 \uc804\uc0ac\uccb4\ub97c \uc5f0\uad6c\ud558\uae30 \uc704\ud574 \uac1c\ubcc4 \uc2e4\ud5d8\ub3c4 \uc9c4\ud589\ud574\uc57c \uaca0\uc9c0\ub9cc \uc774 \uc2dc\uae30 \ubc30\uc544\uc758 \ubc1c\ub2ec \uacfc\uc815\uc5d0\uc120 \ub531 \ud55c\uac00\uc9c0 \uc6d0\uc778\ub9cc \uc788\ub294 \uac83\uc774 \uc544\ub2c8\uae30 \ub54c\ubb38\uc5d0 \uc804\uccb4 \uc0c1\ud638\uc791\uc6a9\uc744 \ubcf4\ub294 \uc5f0\uad6c\uac00 \ud544\uc694\ud558\ub2e4\u201d\uba70 \u201c(\uc774\ubc88 \uc5f0\uad6c\ucc98\ub7fc) \uc218\ub9cc\uac1c \uc774\uc0c1\uc758\u00a0RNA<\/span>\uc804\uc0ac\uccb4\ub4e4\uc758 \uc0c1\ud638 \uc791\uc6a9\uacfc\uc815\ub97c \ubd84\uc11d\ud574 \ubc1c\uc0dd \uacfc\uc815\uc744 \uc785\uccb4\uc801\uc73c\ub85c \uad6c\uc131\ud558\ub294 \ub178\ub825\uc774 \uacc4\uc18d\ub3fc\uc57c \ud560 \uac83\u201d\uc774\ub77c\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

    (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~)     RNA \uac04\uc12d\uc774 \uc720\uc804\uc790 \ubc1c\ud604\uc744 \uc870\uc808\ud55c\ub2e4?   \uc0dd\uba85\uc5d0 \uad00\ud55c \uc720\uc804\uc815\ubcf4\ub97c \ub2f4\uace0 \uc788\ub294\u00a0DNA\ub294\u00a0\ub450 \uac00\ub2e5\uc758 \uc774\uc911\ub098\uc120 \uad6c\uc870\ub97c \uc774\ub8e8\uace0 \uc788\ub2e4. DNA\uc758 \uc720\uc804\uc815\ubcf4\ub97c(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[33,34,29,30],"tags":[],"class_list":["post-1683","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-chemistry","category-lets-do-science","category-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":1876,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1876","url_meta":{"origin":1683,"position":0},"title":"\uaf2c\ub9ac\uac00 \uae38\uba74 \ubc1f\ud788\ub294 \ubc95, mRNA\uc758 \uaf2c\ub9ac\ub97c \ucc3e\uc544\uc11c","author":"biochemistry","date":"September 26, 2018","format":false,"excerpt":"\u00a0 \u00a0 mRNA \uaf2c\ub9ac\uc5d0 \uad00\ud55c \uc11c\uc6b8\ub300 \uae40\ube5b\ub0b4\ub9ac \uad50\uc218\ub2d8\uc758 \ucd5c\uadfc \ub17c\ubb38 \uc124\uba85\uc785\ub2c8\ub2e4~ (\uc6d0\ubb38) \u00a0 \ub2e8\ubc31\uc9c8\uacfc \uc138\ud3ec\uc758 \uc6b4\uba85 \uacb0\uc815\uc790, \uc804\ub839RNA(mRNA) \uace0\ud608\uc555 \ud658\uc790\uc640 \ub9c8\ub77c\ud1a4 \uc120\uc218\uc758 \uacf5\ud1b5\uc810\uc774 \uc788\ub2e4.\u00a0\uc2ec\uc7a5\uc774 \uc77c\ubc18 \uc0ac\ub78c\ubcf4\ub2e4 \ud06c\ub2e4\ub294 \uac83.\u00a0\ub450 \uc0ac\ub78c \ubaa8\ub450 \ucee4\ub2e4\ub780 \uc2ec\uc7a5\uc744 \uac00\uc84c\ub2e4\ub294 \uc870\uac74\uc740 \uac19\ub2e4.\u00a0\ud558\uc9c0\ub9cc \uac74\uac15 \uce21\uba74\uc5d0\uc11c \uacb0\uacfc\ub294 \ub2e4\ub974\ub2e4.\u00a0\uace0\ud608\uc555 \ud658\uc790\ub294 \uc2ec\uc7a5\ub9c8\ube44\ub97c \uc553\uc744 \uac00\ub2a5\uc131\uc774 \ud06c\uc9c0\ub9cc \ub9c8\ub77c\ud1a4 \uc120\uc218\ub294 \ub300\uccb4\uc801\uc73c\ub85c \uac74\uac15\ud55c \uc0b6\uc744 \uc0b0\ub2e4.\u00a0\uc774\uc720\uac00\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/163.180.4.222\/lab\/wp-content\/uploads\/2018\/09\/200211140272_01-300x210.jpg?resize=350%2C200","width":350,"height":200},"classes":[]},{"id":1360,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1360","url_meta":{"origin":1683,"position":1},"title":"G\ufeffene-silencing technology gets first drug approval after 20-year wait & RNA\uac04\uc12d, 20\ub144 \ub9cc\uc5d0 \uc758\uc57d\ud488\uc73c\ub85c \uacb0\uc2e4 \ub9fa\ub2e4!","author":"biochemistry","date":"August 14, 2018","format":false,"excerpt":"\u00a0 \u00a0 \ub4dc\ub514\uc5b4 RNAi \uae30\ubc18\uc758 \uc57d\uc774 FDA \uc2b9\uc778\uc744 \ubc1b\uc558\uad70\uc694^^ \u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 \u00a0 The US Food and Drug Administration\u2019s decision breathes new life into RNA-interference therapies. \u00a0 US regulators have approved the first therapy based on RNA interference (RNAi), a technique that can be used to silence specific\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2122,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2122","url_meta":{"origin":1683,"position":2},"title":"RNA \ubc14\uafd4\uc11c \ud559\uc5c5\uc131\uc801 \ub192\uc774\uace0 \uae30\uc5b5\ub825 \ud5a5\uc0c1\uc2dc\ud0a8\ub2e4\uace0?","author":"biochemistry","date":"November 4, 2018","format":false,"excerpt":"\u00a0 mRNA\u00a0\ubcc0\ud615\uc774 \uae30\uc5b5\uacfc \ud559\uc2b5\ub2a5\ub825 \ud5a5\uc0c1\uc5d0 \ub3c4\uc6c0\uc774 \ub41c\ub2e4\ub294 \uc5f0\uad6c\uacb0\uacfc\uac00 \ub098\uc654\ub2e4.\uc0ac\uc774\uc5b8\uc2a4 \ub370\uc77c\ub9ac \u00a0 \ub2e8\ubc31\uc9c8\uc740 \uc0dd\uba85\uccb4 \uc791\ub3d9\uc5d0 \uc788\uc5b4\uc11c \ud544\uc218\uc801\uc778 \ub2e8\uc704\uc774\ub2e4.\u00a0\ub2e8\ubc31\uc9c8 \uc0dd\uc0b0\uc744 \uc704\ud574\uc11c\ub294\u00a0DNA\uc640\u00a0RNA\uc758 \uc720\uae30\uc801 \uc870\uc815\uc774 \ud544\uc694\ud558\ub2e4.\u00a0RNA\ub294 \ubb34\uc218\ud55c \uc885\ub958\uc758 \ub2e8\ubc31\uc9c8\uc744 \ub9cc\ub4e4 \ub54c \uc9c1\uc811 \uc791\uc6a9\ud558\ub294 \uace0\ubd84\uc790 \ud654\ud569\ubb3c\uc774\uace0\u00a0DNA\ub294\u00a0RNA\uc758 \uc791\uc6a9\uc744 \uc870\uc808\ud558\ub294 \uc5ed\ud560\uc744 \ud55c\ub2e4. \uc989\u00a0RNA\ub294\u00a0DNA\uac00 \uac16\uace0 \uc788\ub294 \uc720\uc804\uc815\ubcf4\uc5d0 \ub530\ub77c \ud544\uc694\ud55c \ub2e8\ubc31\uc9c8\uc744 \ud569\uc131\ud558\ub294 \uc5ed\ud560\uc744 \ud558\ub294 \ubb3c\uc9c8\uc774\ub2e4. \ucd5c\uadfc \uc911\uad6d\uacfc \ubbf8\uad6d \uc5f0\uad6c\uc790\ub4e4\uc774\u00a0RNA\uc758\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2590,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2590","url_meta":{"origin":1683,"position":3},"title":"DNA \ud3b8\uc9d1\uc744 \uc704\ud55c \uc0c8 \ub3c4\uad6c","author":"biochemistry","date":"January 30, 2019","format":false,"excerpt":"\u00a0 \u00a0 [\uc694\uc57d]\ubbf8\uad6d\u00a0MIT\uc640 \ud558\ubc84\ub4dc\ub300 \uacf5\ub3d9\uc5f0\uad6c\ud300\uc774 \uc720\uc804\uc790 \uac00\uc704\uc778 \ud06c\ub9ac\uc2a4\ud37c\uc5d0 \ud65c\uc6a9\ud560 \uc218 \uc788\ub294 \uc0c8\ub85c\uc6b4 \uae30\uc220\uc744 \uc644\uc131\ud588\ub2e4.\u00a0\uc774 \ud06c\ub9ac\uc2a4\ud37c \uc720\uc804\uc790 \uac00\uc704\ub294 \ud604\uc7ac \ub110\ub9ac \ud65c\uc6a9\ub418\ub294 \ub3c4\uad6c \uc138\ud2b8\uc640\u00a0\ube44\uad50\ud560 \ub54c 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\ud558\ub098\ud558\ub098\ub97c \ubc30\uc544\u2026","rel":"","context":"In "Let's Do Science!"","block_context":{"text":"Let's Do Science!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=29"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2828,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2828","url_meta":{"origin":1683,"position":5},"title":"CRISPR\uae30\uc220\uc774 \uc5b4\ub5bb\uac8c \uc2e0\uc57d\uac1c\ubc1c\uc744 \ucd09\uc9c4\ud558\ub294\uac00?","author":"biochemistry","date":"March 15, 2019","format":false,"excerpt":"\u00a0 CRISPR\uae30\uc220\uc774 \uc5b4\ub5bb\uac8c \uc2e0\uc57d\uac1c\ubc1c\uc744 \ucd09\uc9c4\ud558\ub294\uac00? \u00a0 \u25c7 3\uc138\ub300 \uc720\uc804\uc790\ud3b8\uc9d1\uae30\uc220\uc778 CRISPR\uae30\uc220\uc740 \uc720\uc804\uc790\u00b7\uc138\ud3ec\uce58\ub8cc\uc81c \ub4f1 \ucc28\uc138\ub300 \ubc14\uc774\uc624\uc2e0\uc57d \uac1c\ubc1c \uc678\uc5d0 \uc804\ud1b5\uc801\uc778 \ud569\uc131\uc2e0\uc57d \ubc1c\uad74 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