\uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n <\/p>\n
Science\u00a0<\/cite>\u00a007 Sep 2018:
\nVol. 361, Issue 6406, pp. 988
\nDOI: 10.1126\/science.361.6406.988-b<\/p>\n <\/p>\n
Phenylketonuria is a disease caused by an inability to metabolize the amino acid phenylalanine, which can accumulate in the blood and brain, causing neurotoxicity. Patients are treated by restricting phenylalanine intake through a low-protein diet, but this can cause failure to thrive. To improve the therapeutic options, Isabella\u00a0et al.<\/em>developed a probiotic that meets the current requirements for clinical testing. They engineered a strain of\u00a0Escherichia coli<\/em>\u00a0with a strong safety profile in humans to inducibly express a phenylalanine-degrading enzyme. Oral administration of this probiotic in a mouse model of phenylketonuria prevented increased phenylalanine concentrations in the blood when the mice were injected with phenylalanine, suggesting that gastrointestinal degradation can regulate circulating phenylalanine concentrations. Thus, this synthetic probiotic could have potential in clinical trials.<\/p>\n <\/p>\n
<\/p>\n
Nat. Biotechnol.<\/em>\u00a010.1038\/nbt.4222 (2018).<\/p>\n <\/p>\n
<\/p>\n
<\/p>\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
(\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) Science\u00a0\u00a007 Sep 2018: Vol. 361, Issue 6406, pp. 988 DOI: 10.1126\/science.361.6406.988-b Phenylketonuria is a disease caused by an(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[33,29,30],"tags":[7,3,4],"class_list":["post-1591","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","category-recent-science-news","tag-do-biology","tag-lets-do-science","tag-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":1372,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1372","url_meta":{"origin":1591,"position":0},"title":"Live bacteria deliver crucial enzymes straight to the gut","author":"biochemistry","date":"August 14, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 A newborn baby is tested for the genetic disorder phenylketonuria, which may be treatable with bacteria engineered to compensate for an enzyme that patients lack. Credit: Andrew Harrer\/Bloomberg\/Getty \u00a0 Live bacteria deliver crucial enzymes straight to the gut Intestinal microbes can be programmed to make\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":935,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=935","url_meta":{"origin":1591,"position":1},"title":"Genetically modified bacteria enlisted in fight against disease","author":"biochemistry","date":"June 22, 2018","format":false,"excerpt":"\u00a0 \u00a0 \uc774\uc81c \uc9c8\ubcd1 \uce58\ub8cc\ub97c \uc704\ud55c GMB (genetically modified bacteria)\uc778\uac00\uc694? \u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 Engineered strains of\u00a0E. coli\u00a0and other microbes are being tested in people to combat a slew of illnesses. \u00a0 \u00a0 \u00a0 The\u00a0Escherichia coli\u00a0bacteria is being developed as a vehicle for gene therapy in people.Credit: Fernan Federici\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2059,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2059","url_meta":{"origin":1591,"position":2},"title":"Towards therapeutic base editing","author":"biochemistry","date":"October 12, 2018","format":false,"excerpt":"\u00a0 \u00a0 \uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~ \u00a0 Base editors function in mouse fetuses and in the livers of adult mice to treat a genetic disorder. \u00a0 \u00a0 The vast majority of genetic diseases are caused by single-nucleotide mutations rather than chromosomal rearrangements or small insertions or deletions (indels) and hence could\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3466,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3466","url_meta":{"origin":1591,"position":3},"title":"The pros, cons, and many unknowns of probiotics","author":"biochemistry","date":"May 7, 2019","format":false,"excerpt":"\u00a0 \u00a0 Abstract Consumption of over-the-counter probiotics for promotion of health and well-being has increased worldwide in recent years. However, although probiotic use has been greatly popularized among the general public, there are conflicting clinical results for many probiotic strains and formulations. Emerging insights from microbiome research enable an assessment\u2026","rel":"","context":"In "Essays on Science"","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4207,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4207","url_meta":{"origin":1591,"position":4},"title":"The structure of DNA","author":"biochemistry","date":"October 11, 2019","format":false,"excerpt":"\u00a0 \u00a0 In the early 1950s, the identity of genetic material was still a matter of debate. The discovery of the helical structure of double-stranded DNA settled the matter \u2014 and changed biology forever. \u00a0 \u00a0 On 25 April 1953, James Watson and Francis Crick announced1\u00a0in\u00a0Nature\u00a0that they \u201cwish to suggest\u201d\u00a0a\u2026","rel":"","context":"In "Essays on Science"","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1434,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1434","url_meta":{"origin":1591,"position":5},"title":"Humans as models of human disease","author":"biochemistry","date":"August 24, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) \u00a0 Science\u00a0\u00a024 Aug 2018: Vol. 361, Issue 6404, pp. 763-764 DOI: 10.1126\/science.361.6404.763-e \u00a0 Mice are a convenient model for exploring the functions of cellular signaling pathways. 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