{"id":1535,"date":"2018-09-02T06:19:41","date_gmt":"2018-09-02T06:19:41","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=1535"},"modified":"2019-10-15T19:27:32","modified_gmt":"2019-10-15T10:27:32","slug":"canine-crispr-trial-raises-%ef%bb%bfhopes-for-humans-with-deadly-disease","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1535","title":{"rendered":"Canine CRISPR trial raises \ufeffhopes for humans with deadly disease"},"content":{"rendered":"

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Dogs with a disorder similar to Duchenne muscular dystrophy improve after gene-editing treatment.<\/h5>\n

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A powerful gene-editing technique can stimulate dogs\u2019 production of an important muscle protein, a finding that takes researchers a step closer to trying the technology in humans who have a fatal deficit in the same molecule.<\/p>\n

People with the genetic disease Duchenne muscular dystrophy cannot synthesize dystrophin, a component of the scaffolding inside muscle cells. This deficiency results in muscle wasting and early death. The CRISPR\u2013Cas9 gene-editing system has previously been used to trigger dystrophin production in mice, but Eric Olson at the University of Texas Southwestern Medical Center in Dallas and his colleagues sought to test the technique in a larger animal.<\/p>\n

The researchers treated four dogs \u2014 all lacking dystrophin because of a genetic mutation \u2014 with the CRISPR\u2013Cas9 system, which snipped out a short stretch of the animals\u2019 DNA. This allowed the dogs\u2019 cells to make dystrophin. Levels of the protein in one dog\u2019s heart muscle reached 92% of normal.<\/p>\n

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Science<\/i>\u00a0(2018)<\/a><\/p>\n<\/div>\n

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    (\uc6d0\ubb38)     Dogs with a disorder similar to Duchenne muscular dystrophy improve after gene-editing treatment.     A powerful gene-editing technique can(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[33,29,30],"tags":[7,3,4],"class_list":["post-1535","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","category-recent-science-news","tag-do-biology","tag-lets-do-science","tag-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":1857,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1857","url_meta":{"origin":1535,"position":0},"title":"CRISPR-Cas9 nuclease \uad00\ub828 \uba87 \uac00\uc9c0 \ub274\uc2a4","author":"biochemistry","date":"September 25, 2018","format":false,"excerpt":"\u00a0 \u00a0 CRISPR-Cas9\uacfc \uad00\ub828\ub41c \uba87 \uac00\uc9c0 \uc18c\uc2dd\uc785\ub2c8\ub2e4. (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) \u00a0 CRISPR tool puts RNA on the record \u00a0 The bacterial-defence system CRISPR\u2013Cas can store DNA snippets that correspond to encountered viral RNA sequences. One such system has now been harnessed to record gene expression over time in bacteria. \u00a0\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4854,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4854","url_meta":{"origin":1535,"position":1},"title":"Got mutation? \u2018Base editors\u2019 fix genomes one nucleotide at a time","author":"biochemistry","date":"November 19, 2019","format":false,"excerpt":"\u00a0 \u00a0 A new class of CRISPR-based tools efficiently corrects point mutations in cell lines, animal models and perhaps the clinic. \u00a0 \u00a0 Credit: Getty \u00a0 \u00a0 When Xingxu Huang began thinking about correcting disease-causing mutations in the human genome, his attention turned naturally to CRISPR\u2013Cas9. But it quickly became\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":976,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=976","url_meta":{"origin":1535,"position":2},"title":"CRISPR with a heart of gold helps ailing mice","author":"biochemistry","date":"June 28, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 \u00a0 Gene-editing molecules ride gold nanoparticles into the brain. \u00a0 Expression of a protein (blue-green, left) associated with fragile X syndrome is suppressed (right) in the brains of mice treated with CRISPR gene-editing molecules. Credit: B. Lee\u00a0et al.\/Nature\u00a0Biomed. Eng. \u00a0 \u00a0 Scientists are mining gold\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3986,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3986","url_meta":{"origin":1535,"position":3},"title":"The CRISPR animal kingdom","author":"biochemistry","date":"August 3, 2019","format":false,"excerpt":"\u00a0 \u00a0 China has used the genome editor more aggressively, on more species, than any other country. \u00a0 After using CRISPR to edit a gene that disrupts circadian rhythms in a monkey, Chinese researchers then produced five clones. PHOTO: XINHUA\/INSTITUTE OF NEUROSCIENCE\/CHINESE ACADEMY OF SCIENCES\/REDUX \u00a0 \u00a0 Early one February\u2026","rel":"","context":"In "Essays on Science"","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1313,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1313","url_meta":{"origin":1535,"position":4},"title":"Did CRISPR really fix a genetic mutation in these human embryos?","author":"biochemistry","date":"August 9, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 Researchers provide more evidence for their landmark claim that gene editing rid embryos of a disease mutation \u2014 but scientists are still arguing over the results. \u00a0 \u00a0 Eight-cell embryos injected with the gene editor CRISPR\u2013Cas9.Credit: H. Ma et al.\/Nature \u00a0 \u00a0 \u00a0 Biologists who\u2026","rel":"","context":"In "Essays on Science"","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3984,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3984","url_meta":{"origin":1535,"position":5},"title":"Enriching stem cells for gene editing","author":"biochemistry","date":"August 3, 2019","format":false,"excerpt":"\u00a0 \u00a0 Gene editing using CRISPR-Cas9 may allow targeted treatment for a variety of genetic diseases. These include inherited abnormalities of \u03b2 hemoglobin, which can be indirectly targeted by increasing the amount of healthy fetal hemoglobin without fully correcting the disease-causing mutation. Humbert\u00a0et al.\u00a0used CRISPR-based gene editing to modify hematopoietic\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]}],"jetpack_sharing_enabled":false,"jetpack_shortlink":"https:\/\/wp.me\/p9Xo1j-oL","_links":{"self":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/1535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1535"}],"version-history":[{"count":1,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/1535\/revisions"}],"predecessor-version":[{"id":4419,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=\/wp\/v2\/posts\/1535\/revisions\/4419"}],"wp:attachment":[{"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1535"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1535"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biochemistry.khu.ac.kr\/lab\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}