{"id":1372,"date":"2018-08-14T15:27:37","date_gmt":"2018-08-14T15:27:37","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=1372"},"modified":"2019-10-15T19:03:49","modified_gmt":"2019-10-15T10:03:49","slug":"live-bacteria-deliver-crucial-enzymes-straight-to-the-gut","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1372","title":{"rendered":"Live bacteria deliver crucial enzymes straight to the gut"},"content":{"rendered":"

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A newborn baby is tested for the genetic disorder phenylketonuria, which may be treatable with bacteria engineered to compensate for an enzyme that patients lack. Credit: Andrew Harrer\/Bloomberg\/Getty<\/p>\n<\/figcaption><\/figure>\n

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Live bacteria deliver crucial enzymes straight to the gut<\/h6>\n
Intestinal microbes can be programmed to make up for a deficiency that causes a devastating inherited disorder.<\/div>\n

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Bacteria that live in the human gut have been engineered to churn out two key enzymes, providing a possible treatment for a serious genetic disease.<\/p>\n

People born with phenylketonuria (PKU) cannot process the amino acid phenylalanine, which is found in most proteins. Even an extremely low-protein diet may not protect people with PKU from cognitive impairments caused by a build-up of phenylalanine.<\/p>\n

A team led by Vincent Isabella at the therapeutics firm Synlogic in Cambridge, Massachusetts, inserted the genes for two enzymes that can break down phenylalanine into the\u00a0Escherichia coli<\/i>\u00a0strain \u2018Nissle\u2019, a bacterium often taken as a probiotic. The engineered microbe slashed levels of phenylalanine in the blood of mice with a version of the disease. Healthy monkeys that were fed both protein and engineered bacteria experienced smaller spikes of phenylalanine in their blood than monkeys that ate only protein.<\/p>\n

The results suggest that the bacterium might offer a way to prevent the toxic build-up of phenylalanine in people with PKU. A clinical trial is now evaluating the microbe\u2019s safety in humans.<\/p>\n

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Nature Biotechnol.<\/i>\u00a0(2018)<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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    (\uc6d0\ubb38)     A newborn baby is tested for the genetic disorder phenylketonuria, which may be treatable with bacteria engineered to compensate for(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[33,29,30],"tags":[7,3,4],"class_list":["post-1372","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","category-recent-science-news","tag-do-biology","tag-lets-do-science","tag-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":3815,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3815","url_meta":{"origin":1372,"position":0},"title":"Microbes make metabolic mischief by targeting drugs","author":"biochemistry","date":"June 19, 2019","format":false,"excerpt":"\u00a0 \u00a0 Tests of whether a range of gut bacteria can metabolize a diverse group of drugs has revealed that all the microbes metabolized some drugs and that more than half of the drugs were metabolized. \u00a0 \u00a0 All humans are different and, unsurprisingly, also differ in their response to\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":935,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=935","url_meta":{"origin":1372,"position":1},"title":"Genetically modified bacteria enlisted in fight against disease","author":"biochemistry","date":"June 22, 2018","format":false,"excerpt":"\u00a0 \u00a0 \uc774\uc81c \uc9c8\ubcd1 \uce58\ub8cc\ub97c \uc704\ud55c GMB (genetically modified bacteria)\uc778\uac00\uc694? \u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 Engineered strains of\u00a0E. coli\u00a0and other microbes are being tested in people to combat a slew of illnesses. \u00a0 \u00a0 \u00a0 The\u00a0Escherichia coli\u00a0bacteria is being developed as a vehicle for gene therapy in people.Credit: Fernan Federici\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3497,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3497","url_meta":{"origin":1372,"position":2},"title":"How many metals to oxidize methane?","author":"biochemistry","date":"May 10, 2019","format":false,"excerpt":"\u00a0 \u00a0 Methane is an important fuel, but there are few direct transformations to partially oxidized products. 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