{"id":1366,"date":"2018-08-14T15:20:53","date_gmt":"2018-08-14T15:20:53","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=1366"},"modified":"2019-10-15T19:03:00","modified_gmt":"2019-10-15T10:03:00","slug":"mini-tumours-turn-immune-cells-into-cancer-fighters","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1366","title":{"rendered":"Mini-tumours turn immune cells into cancer fighters"},"content":{"rendered":"

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Tumour \u2018organoids\u2019 in lab dishes (left) were seeded with tissue removed from a human lung tumour (right). Credit: K. K. Dijkstra\u00a0et al.<\/i>\/Cell<\/i><\/p>\n<\/figcaption><\/figure>\n

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Mini-tumours turn immune cells into cancer fighters<\/h6>\n
Personalized white blood cells attack tumours after incubation with cancer tissue.<\/div>\n

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Miniature tumours in a dish can be used to give immune cells cancer-killing powers \u2014 and might illuminate why some tumours resist a promising therapy.<\/p>\n

The innovative cancer treatment, called immunotherapy, enlists patients\u2019 own immune systems to fight their cancers. Seeking to advance the approach, Emile Voest of the Netherlands Cancer Institute in Amsterdam and his colleagues obtained tumour cells from people with colorectal or lung cancer and cultured the cells to make patient-specific \u2018organoids\u2019 \u2014 small, 3D versions of whole organs. The researchers also used cancer-free tissue from several of the same patients to make healthy organoids.<\/p>\n

The team isolated immune cells called lymphocytes from patients\u2019 blood and incubated each patient\u2019s lymphocytes with his or her tumour organoid. This increased the number of those immune cells that were able to attack the tumour organoids. But lymphocytes incubated with healthy organoids did not kill their host tissue, suggesting that the technique would not cause serious side effects.<\/p>\n

The scientists say their approach will aid research into why some tumours lose their responsiveness to immunotherapy.<\/p>\n

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Cell<\/i>\u00a0(2018)<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n

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    (\uc6d0\ubb38)     Tumour \u2018organoids\u2019 in lab dishes (left) were seeded with tissue removed from a human lung tumour (right). Credit: K. K.(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[33,29,30],"tags":[7,3,4],"class_list":["post-1366","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","category-recent-science-news","tag-do-biology","tag-lets-do-science","tag-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":404,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=404","url_meta":{"origin":1366,"position":0},"title":"Cancer-killing viruses show promise \u2014 and draw billion-dollar investment","author":"biochemistry","date":"May 30, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 Encouraging trial results spur interest from researchers and drug giants. \u00a0 \u00a0 Researchers are trying to boost the effectiveness of cancer-killing viruses to treat conditions including brain tumours (red).Credit: Sherbrooke Connectivity Imaging Lab\/SPL \u00a0 Pharmaceutical giant Johnson & Johnson announced on 2 May that it\u2026","rel":"","context":"In "Essays on Science"","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4790,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4790","url_meta":{"origin":1366,"position":1},"title":"Small molecule combats cancer-causing KRAS protein at last","author":"biochemistry","date":"November 11, 2019","format":false,"excerpt":"\u00a0 \u00a0 A molecule has now been characterized that acts to inhibit a cancer-causing form of KRAS protein and stimulate the immune system. 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