{"id":1360,"date":"2018-08-14T15:12:34","date_gmt":"2018-08-14T15:12:34","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=1360"},"modified":"2019-10-16T11:54:41","modified_gmt":"2019-10-16T02:54:41","slug":"g%ef%bb%bfene-silencing-technology-gets-first-drug-approval-after-20-year-wait","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1360","title":{"rendered":"G\ufeffene-silencing technology gets first drug approval after 20-year wait & RNA\uac04\uc12d, 20\ub144 \ub9cc\uc5d0 \uc758\uc57d\ud488\uc73c\ub85c \uacb0\uc2e4 \ub9fa\ub2e4!"},"content":{"rendered":"

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\ub4dc\ub514\uc5b4 RNAi \uae30\ubc18\uc758 \uc57d\uc774 FDA \uc2b9\uc778\uc744 \ubc1b\uc558\uad70\uc694^^<\/p>\n

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(\uc6d0\ubb38<\/a>)<\/p>\n

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The US Food and Drug Administration\u2019s decision breathes new life into RNA-interference therapies.<\/h6>\n

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US regulators have approved the first therapy based on RNA interference (RNAi), a technique that can be used to silence specific genes linked to disease. The drug, patisiran, targets a rare condition that can impair heart and nerve function.<\/p>\n

The approval, announced by the US Food and Drug Administration on 10 August, is a landmark for a field that has struggled for nearly two decades to prove its worth in the clinic. Researchers first discovered RNAi 20 years ago1<\/a><\/sup>, sparking hopes of a revolutionary new approach to medicine. Since then, however, a series of setbacks has lessened those expectations.<\/p>\n

\u201cThis approval is key for the RNAi field,\u201d says James Cardia, head of business development at RXi Pharmaceuticals in Marlborough, Massachusetts, which is developing RNAi treatments. \u201cThis is transformational.\u201d<\/p>\n

Patisiran works by silencing the gene that underlies a rare disease called hereditary transthyretin amyloidosis. In that illness, mutated forms of the protein transthyretin accumulate in the body, sometimes impairing heart and nerve function.<\/p>\n

The drug’s approval means that pharmacology textbooks will need to be rewritten, says Ricardo Titze-de-Almeida, who studies RNAi at the University of Brasilia. \u201cWe are inaugurating a new pharmacological group,\u201d he says. \u201cWe will have many more such drugs in the coming years.\u201d<\/p>\n

This was the hope when Alnylam, the company in Cambridge, Massachusetts, that developed patisiran, launched in 2002. Four years later, the\u00a0Nobel Prize in Physiology or Medicine was awarded to two RNAi pioneers<\/a>: Andrew Fire of Stanford University School of Medicine in California and Craig Mello of the University of Massachusetts Medical School in Worcester.<\/p>\n

But to make RNAi into medicine, developers would first need to determine\u00a0how to deliver delicate molecules of RNA safely<\/a>\u00a0to their target organs. They needed a way to shield the RNA from degradation in the bloodstream, prevent it from being filtered out by the kidneys, and allow it to exit blood vessels and spread through tissues. \u201cThat proved to be a substantially harder problem than we anticipated,\u201d says Douglas Fambrough, chief executive of Dicerna, an RNAi-focused company in Cambridge, Massachusetts.<\/p>\n

As researchers grappled with the delivery puzzle, investors began to lose confidence. In 2008, analyst Edward Tenthoff of investment bank Piper Jaffray in New York City advised his clients to stop buying Alnylam stock. \u201cWe saw the promise in the technology, but the delivery was lacking,\u201d he says.<\/p>\n

By 2010,\u00a0large pharmaceutical companies were also losing their appetite for RNAi<\/a>, severing collaborations and ending internal research programmes. \u201cBy and large, big pharma left RNAi for dead,\u201d says Fambrough. Safety concerns dealt the field another blow in 2016, when\u00a0Alnylam abandoned one of its leading RNAi programmes<\/a>\u00a0after finding a possible link to patient deaths in a clinical trial.<\/p>\n

But gradually, some RNAi companies began to iron out the kinks in their delivery systems, and Tenthoff started to encourage investors to buy stock again. Alnylam experimented with a number of delivery routes and target organs, encasing some of its RNA molecules in fatty nanoparticles orchemically modifying the RNAs to help them survive the perilous journey through the bloodstream.<\/p>\n

RNAs protected in this way and injected into the bloodstream tended to accumulate in the kidneys and liver. This led the company to look at transthyretin, which is produced mainly in the liver. In a clinical trial in 225 people with hereditary transthyretin amyloidosis who showed signs of nerve damage, average walking speed significantly improved in those who received the treatment2<\/a><\/sup>. Walking speed declined in the placebo group.<\/p>\n

In the future, Alnylam and others will be able to move beyond the liver, says company co-founder Thomas Tuschl, a biochemist at Rockefeller University in New York City. Quark Pharmaceuticals of Fremont, California is testing RNAi therapies that target proteins in the kidneys and the eye. Alnylam is developing ways to target the brain and spinal cord, and Arrowhead Pharmaceuticals of Pasadena, California, is working on an inhalable RNAi treatment for cystic fibrosis.<\/p>\n

\u201cI\u2019ve never been more optimistic about the future of RNAi,\u201d says Fambrough. \u201cAll of those tear-your-hair-out days were worth it to get to today.\u201d<\/p>\n

Advances in RNA delivery might also benefit researchers who are developing gene-editing therapies based on the popular technique CRISPR\u2013Cas9. That system uses a DNA-cutting protein called Cas9, which is guided to the desired site in the genome by an RNA molecule.<\/p>\n

Like RNAi before it, CRISPR\u2013Cas9 has become a common tool in genetics laboratories. But it might still face a difficult and lengthy path to the clinic. Much like ordinary drugs, RNAi therapies will break down over time; a gene edit, however, is intended to be permanent, which amplifies concerns about safety.<\/p>\n

\u201cI hope they can do it more quickly than we did it, but I would not expect it to be so smooth,\u201d says Fambrough. \u201cI wish them the best of luck.\u201d<\/p>\n

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Nature<\/span>\u00a0560<\/strong>, 291-292 (2018)<\/p>\n

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doi: 10.1038\/d41586-018-05867-7<\/div>\n<\/div>\n

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http:\/\/dongascience.donga.com\/news\/view\/23400<\/p>\n

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RNA\uac04\uc12d, 20\ub144 \ub9cc\uc5d0 \uc758\uc57d\ud488\uc73c\ub85c \uacb0\uc2e4 \ub9fa\ub2e4!<\/h5>\n

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\ub9e4\ub144 10\uc6d4 \ub178\ubca8\uacfc\ud559\uc0c1 \uc218\uc0c1\uc790\uac00 \ubc1c\ud45c\ub418\uba74 \ubd84\uc57c\uc5d0 \ub530\ub77c \ubc18\uc751\uc774 \ucc9c\ucc28\ub9cc\ubcc4\uc774\ub2e4. \uc9c0\ub09c\ud574 \uc0dd\uccb4\uc2dc\uacc4 \uac19\uc740 \uacbd\uc6b0\ub294 \ub0b4\uc6a9\uc774 \uc5b4\ub835\uc9c0 \uc54a\uace0 \uc6b0\ub9ac\uac00 \uccb4\ud5d8\ud558\ub294 \ud604\uc0c1\uc774\uae30\ub3c4 \ud574\uc11c \uad00\uc2ec\uc774 \ub192\uc558\ub2e4. \ubc18\uba74 \uc5b4\ub5a4 \uacbd\uc6b0\ub294 \uadf8\ub7f0 \ubd84\uc57c\uac00 \uc788\uc5c8\ub294\uc9c0\ub3c4 \ubab0\ub790\ub358\uc9c0\ub77c \uc5b4\ub9ac\ub465\uc808\ud558\ub2e4.<\/p>\n

2006\ub144 \ub178\ubca8\uc0dd\ub9ac\uc758\ud559\uc0c1\uc774 \uadf8\ub7f0 \uacbd\uc6b0\ub85c, \u2018RNA<\/span>\uac04\uc12d(interference<\/span>)\u2019 \ud604\uc0c1\uc744 \ubc1c\uacac\ud55c \uc0dd\ubb3c\ud559\uc790 \ub450 \uc0ac\ub78c\uc774 \uc218\uc0c1\ud588\ub2e4.\u00a0RNA<\/span>\uc57c\u00a0DNA<\/span>\uc640 \ube44\uc2b7\ud55c \uc0dd\uccb4\ubd84\uc790\ub77c\uace0 \ubc30\uc6b4 \uac83 \uac19\uc740\ub370, \uc0ac\ub78c\ub3c4 \uc544\ub2cc \ubd84\uc790\uac00 \ubb58 \uac04\uc12d\ud55c\ub2e4\ub294 \uac74\uc9c0 \uc9d0\uc791\ub3c4 \uc548 \ub41c\ub2e4.<\/p>\n

\uc0ac\uc2e4\u00a0RNA<\/span>\uac04\uc12d\uc740 1998\ub144 \ucc98\uc74c \ubcf4\uace0\ub41c \ud604\uc0c1\uc73c\ub85c \ubd88\uacfc 8\ub144 \ub9cc\uc5d0 \uc120\uc815\ub41c \uac83\uc774\ub2e4. \ub178\ubca8\uc0c1\uc774 \uc774\ub807\uac8c \ube68\ub9ac \uc8fc\uc5b4\uc9c0\ub294 \uac74 \ud754\uce58 \uc54a\uc740 \uc77c\ub85c \uadf8\ub9cc\ud07c \uc911\uc694\ud55c \ubc1c\uacac\uc774\ub77c\ub294 \ub73b\uc774\ub2e4. \ub2e4\ub9cc \ub300\uc911\uc5d0\uac8c \ubbf8\ucc98 \uc54c\ub824\uc9c0\uae30\ub3c4 \uc804\uc5d0 \ub178\ubca8\uc0c1\uc744 \ubc1b\uc544 \uc774\ub7f0 \ubc18\uc751\uc774 \ub098\uc628 \uac83\uc774\ub2e4.<\/p>\n

RNA<\/span>\uac04\uc12d\uc774 \ubc1c\uacac \uc989\uc2dc \ub192\uac8c \ud3c9\uac00\ub41c \uac74 \uc720\uc804\uc790\uc758 \ubc1c\ud604\uc744 \uc870\uc808\ud558\ub294 \uc804\ud600 \uc0c8\ub85c\uc6b4 \uba54\ucee4\ub2c8\uc998\uc778 \ub370\ub2e4 \uadf8 \uc7a0\uc7ac\ub825\ub3c4 \uc5c4\uccad\ub0ac\uae30 \ub54c\ubb38\uc774\ub2e4. \uc989\u00a0RNA<\/span>\uac04\uc12d\uc73c\ub85c \ud2b9\uc815 \uc720\uc804\uc790\uc758 \ubc1c\ud604\uc744 \uc27d\uac8c \uc870\uc808\ud560 \uc218 \uc788\uc5b4 \ub9ce\uc740 \uc544\uc774\ub514\uc5b4\ub97c \uc2e4\ud5d8\uc73c\ub85c \ud655\uc778\ud560 \uc218 \uc788\uac8c \ub410\uace0,\u00a0RNA<\/span>\uac04\uc12d \uc57d\ubb3c\uc744 \ub9cc\ub4e4\uba74 \uc758\ud559\uacc4\uc758 \ud601\uba85\uc744 \ubab0\uace0 \uc62c \uc218\ub3c4 \uc788\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n

\uadf8\ub7ec\ub098 \ubaa8\ub4e0 \uac8c \uc608\uc0c1\ub300\ub85c \ub418\uc9c0\ub294 \uc54a\uc558\ub2e4.\u00a0RNA<\/span>\uac04\uc12d\uc740 \uc624\ub298\ub0a0 \uc0dd\uba85\uacfc\ud559 \uc2e4\ud5d8\uc5d0 \uc77c\uc0c1\uc801\uc73c\ub85c \uc4f0\uc774\uace0 \uc788\uc9c0\ub9cc \uc774\ub97c \uc801\uc6a9\ud55c \uc758\uc57d\ud488\uc740 \ub098\uc624\uc9c0 \uc54a\uace0 \uc788\ub2e4.\u00a0RNA<\/span>\uac04\uc12d\uc744 \uc5f0\uad6c\ud558\ub294 \ub9ce\uc740 \ubca4\ucc98\uc5d0 \uc5c4\uccad\ub09c \ub3c8\uc744 \uc3df\uc544\ubd80\uc5c8\uc74c\uc5d0\ub3c4 \ubcc4 \uc9c4\uc804\uc774 \uc5c6\ub294 \uac78\ub85c \uc54c\uace0 \uc788\uc5c8\ub2e4.<\/p>\n

\uadf8\ub7f0\ub370 \uc9c0\ub09c 10\uc77c \ubbf8 \uc2dd\ud488\uc758\uc57d\uad6d(FDA<\/span>)\uc740 \ucd5c\ucd08\uc758\u00a0RNA<\/span>\uac04\uc12d \uc758\uc57d\ud488\uc744 \uc2b9\uc778\ud55c\ub2e4\uace0 \ubc1c\ud45c\ud588\ub2e4. \ubbf8\uad6d\uc758 \ubc14\uc774\uc624\ubca4\ucc98 \uc568\ub098\uc774\ub78c \ud30c\ub9c8\uc288\ud2f0\uceec\uc988(Alnylam<\/span>\u00a0Pharmaceuticals<\/span>)\uc758 \ud30c\ud2f0\uc2dc\ub780(patisiran<\/span>. \uc81c\ud488\uba85\uc740 \uc628\ud30c\ud2b8\ub85c(Onpattro<\/span>))\uc744 \uc720\uc804\uc131 \ud2b8\ub79c\uc2a4\ud2f0\ub808\ud2f4 \uc544\ubc00\ub85c\uc774\ub4dc\uc99d\uc73c\ub85c \ub9d0\ucd08\uc2e0\uacbd\ubcd1\uc99d\uc744 \uc553\ub294 \ud658\uc790\uc758 \uce58\ub8cc\uc5d0 \uc0ac\uc6a9\ud560 \uc218 \uc788\ub3c4\ub85d \ud5c8\uac00\ud588\ub2e4.\u00a0RNA<\/span>\uac04\uc12d \ud604\uc0c1\uc744 \ubc1c\uacac\ud55c \uc9c0 20\ub144 \ub9cc\uc5d0 \ub9c8\uce68\ub0b4\u00a0RNA<\/span>\uac04\uc12d\uc774 \uc758\ud559\uacc4\uc5d0 \ub370\ubdd4\ud55c \uac83\uc774\ub2e4.<\/p>\n

\ud604\uc7ac \uc568\ub098\uc774\ub78c\uc740 \uc2ed\uc5ec \uac00\uc9c0 \ub2e4\ub978\u00a0RNA<\/span>\uac04\uc12d \uc57d\ubb3c \uc784\uc0c1\uc744 \uc9c4\ud589\ud558\uace0 \uc788\uace0 \ub2e4\ub978 \uc5ec\ub7ec \ud68c\uc0ac\ub4e4\ub3c4 \uc218\uc2ed \uac00\uc9c0 \uc784\uc0c1\uc744 \uc9c4\ud589\ud558\uace0 \uc788\ub2e4. \ud30c\ud2f0\uc2dc\ub780 \uc2b9\uc778\uc744 \uacc4\uae30\ub85c \uba38\uc9c0 \uc54a\uc544\u00a0RNA<\/span>\uac04\uc12d \uc758\uc57d\ud488\uc774 \uc3df\uc544\uc838 \ub098\uc62c \uac83\uc73c\ub85c \ubcf4\uc778\ub2e4. \uc544\uc6b8\ub7ec\u00a0RNA<\/span>\uac04\uc12d \ub18d\uc57d\ub3c4 \ucd9c\uc2dc\uac00 \uba38\uc9c0\uc54a\uc558\ub2e4. \uc758\ud559\uacfc \ub18d\uc5c5\uc5d0 \ud070 \ud30c\uc7a5\uc744 \ubbf8\uce60 \uac83\uc73c\ub85c \ubcf4\uc774\ub294\u00a0RNA<\/span>\uac04\uc12d\uc5d0 \ub300\ud574 \uc54c\uc544\ubcf4\uc790.<\/p>\n

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pixabay<\/span>\u00a0\uc81c\uacf5<\/em><\/span><\/p>\n

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\uc608\uc0c1\uce58 \ubabb\ud55c \uacb0\uacfc \ub098\uc640<\/strong><\/p>\n

1953\ub144\u00a0DNA<\/span>\uc774\uc911\ub098\uc120\uc774 \ubc1d\ud600\uc9c4 \ub4a4 \uacfc\ud559\uc790\ub4e4\uc740\u00a0DNA<\/span>\uc758 \uc5fc\uae30 \uc11c\uc5f4 \uc815\ubcf4\uac00 \uc5b4\ub5bb\uac8c \ub2e8\ubc31\uc9c8\uc758 \uc544\ubbf8\ub178\uc0b0 \uc11c\uc5f4\ub85c \ubc88\uc5ed\ub418\ub294\uc9c0 \ubc1d\ud788\ub294 \uc5f0\uad6c\uc5d0 \ub6f0\uc5b4\ub4e4\uc5c8\ub2e4. \uadf8 \uacb0\uacfc\u00a0DNA<\/span>\uac00 \uba3c\uc800 \uac19\uc740 \uc5fc\uae30\uc21c\uc11c\uc778 \ub2e8\uc77c\uac00\ub2e5 \uc804\ub839RNA<\/span>(mRNA<\/span>)\ub85c \uc804\uc0ac\ub41c \ub4a4 \ub9ac\ubcf4\uc19c\uc5d0\uc11c\u00a0mRNA<\/span>\ub97c \uc77d\uc5b4 \ubc88\uc5ed\uc774 \uc77c\uc5b4\ub09c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uaddc\uba85\ud588\ub2e4.<\/p>\n

\uc774 \uacfc\uc815\uc744 \ub4e4\uc5ec\ub2e4\ubcf4\uba74 \uc5b4\ub835\uc9c0 \uc54a\uac8c \ud55c \uc544\uc774\ub514\uc5b4\uac00 \ub5a0\uc624\ub978\ub2e4.\u00a0mRNA<\/span>\uc758 \uc5fc\uae30\uc11c\uc5f4\uacfc \uc0c1\ubcf4\uc801\uc778 \uc11c\uc5f4\uc758\u00a0RNA<\/span>\u00a0\ub2e8\uc77c\uac00\ub2e5\uc744 \ub9cc\ub4e4\uc5b4 \ub123\uc5b4\uc8fc\uba74\u00a0mRNA<\/span>\uc5d0 \ub2ec\ub77c\ubd99\uc5b4 \uc774\uc911\uac00\ub2e5\uc744 \ub9cc\ub4e4\uace0 \uacb0\uad6d \ubc88\uc5ed\uc774 \uc77c\uc5b4\ub098\uc9c0 \ubabb\ud560 \uac83\uc774\ub2e4. \uc544\ubbf8\ub178\uc0b0\uc758 \uc815\ubcf4, \uc989 \uc758\ubbf8\ub97c \uc9c0\ub2cc\u00a0mRNA<\/span>\ub97c \uc13c\uc2a4(sense<\/span>)\ub77c\uace0 \ubd80\ub974\uace0 \uc5ec\uae30\uc5d0 \uc0c1\ubcf4\uc801\uc778\u00a0RNA<\/span>\ub97c \uc548\ud2f0\uc13c\uc2a4(antisense<\/span>)\ub77c\uace0 \ubd80\ub978\ub2e4.<\/p>\n

1980\ub144\ub300 \uc774 \uc544\uc774\ub514\uc5b4\ub97c \ud655\uc778\ud558\ub294 \uc2e4\ud5d8\uc774 \uc9c4\ud589\ub410\uace0 \uc815\ub9d0 \uc548\ud2f0\uc13c\uc2a4RNA<\/span>\uac00 \uc5b4\ub290 \uc815\ub3c4 \uc720\uc804\uc790 \ubc1c\ud604\uc744 \uc5b5\uc81c\ud558\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\ub2e4. \uadf8\ub7ec\ub098 \ud6c4\uc18d \uc2e4\ud5d8\ub4e4\uc5d0\uc11c \uacb0\uacfc\uac00 \ub4e4\uc465\ub0a0\uc465\ud588\uace0 \uc2ec\uc9c0\uc5b4 \uc13c\uc2a4RNA<\/span>(mRNA<\/span>\uc758 \uc77c\ubd80\ubd84\uacfc \uc11c\uc5f4\uc774 \uac19\uc740 \uc870\uac01)\ub97c \ub123\uc5b4\uc918\ub3c4 \ube44\uc2b7\ud55c \ud6a8\uacfc\uac00 \ub098\ud0c0\ub098\ub294 \ub4f1 \uc774\ud574\uac00 \uc548 \ub418\ub294 \uacb0\uacfc\uac00 \uc774\uc5b4\uc84c\ub2e4.<\/p>\n

\ubbf8\uad6d \uce74\ub124\uae30\uc5f0\uad6c\uc18c\uc758 \uc564\ub4dc\ub8e8 \ud30c\uc774\uc5b4\uc640 \ub9e4\uc0ac\ucd94\uc138\uce20\ub300 \ud06c\ub808\uc774\uadf8 \uba5c\ub85c\ub294 \uc774 \ud63c\ub780\uc744 \uc815\ub9ac\ud558\uae30 \uc704\ud574 \uccb4\uacc4\uc801\uc778 \uc2e4\ud5d8\uc744 \uc124\uacc4\ud574 \uc9c4\ud589\ud588\ub2e4. \uc989 \uc5ec\ub7ec \uc720\uc804\uc790\uc5d0 \ub300\ud574 \uc548\ud2f0\uc13c\uc2a4\uc640 \uc13c\uc2a4, \uadf8\ub9ac\uace0 \ub458 \ub2e4\ub97c \ub123\uc5b4 \ubc1c\ud604 \uc5b5\uc81c \uc815\ub3c4\ub97c \ube44\uad50\ud558\uae30\ub85c \ud55c \uac83\uc774\ub2e4. \uae30\uc874 \uc774\ub860\uc5d0 \ub530\ub974\uba74 \uc548\ud2f0\uc13c\uc2a4RNA<\/span>\ub97c \ub123\uc5b4\uc900 \uc2dc\ub8cc\uc5d0\uc11c\ub9cc \ud6a8\uacfc\uac00 \uc788\uc744 \uac83\uc774\ub2e4.<\/p>\n

\uadf8\ub7ec\ub098 \ub204\uad6c\ub3c4 \uc608\uc0c1\ud558\uc9c0 \ubabb\ud55c \uacb0\uacfc\uac00 \ub098\uc654\ub2e4. \uc13c\uc2a4\ub294 \ubb3c\ub860 \uc548\ud2f0\uc13c\uc2a4\ub3c4 \ud6a8\uacfc\uac00 \uc5c6\uac70\ub098 \ubbf8\ubbf8\ud55c \ubc18\uba74 \ub458\uc744 \ub2e4 \ub123\uc5b4\uc900 \uc2dc\ub8cc\uc5d0\uc11c\ub294 \ub2e8\ubc31\uc9c8\uc774 \uac70\uc758 \ub9cc\ub4e4\uc5b4\uc9c0\uc9c0 \uc54a\ub294 \uac15\ub825\ud55c \ud6a8\uacfc\uac00 \ub098\ud0c0\ub0ac\ub2e4. \uc13c\uc2a4\uc640 \uc548\ud2f0\uc13c\uc2a4\ub97c \uac19\uc774 \ub123\uc5b4\uc8fc\uba74 \uc790\uae30\ub4e4\ub07c\ub9ac \uba3c\uc800 \ub2ec\ub77c\ubd99\uc5b4\u00a0RNA<\/span>\uc774\uc911\uac00\ub2e5\uc744 \ub9cc\ub4e4 \ud150\ub370 \uc5b4\ub5bb\uac8c \uc774\uac8c\u00a0mRNA<\/span>\uc5d0 \uc791\uc6a9\ud560 \uc218 \uc788\uc744\uae4c.<\/p>\n

\ub354 \uc774\uc0c1\ud55c \uac74 \uc138\ud3ec \uc548\uc5d0\uc11c \ub9cc\ub4e4\uc5b4\uc9c8\u00a0mRNA<\/span>\ubcf4\ub2e4 \ud6e8\uc52c \uc801\uc740 \uc591\uc744 \ub123\uc5b4\uc918\ub3c4 \uc774\ub7f0 \ud6a8\uacfc\ub97c \ubcf4\uc778\ub2e4\ub294 \uac83\uc774\ub2e4. \uc774\ub294 \uae30\uc874\uc758 \u20181:1 \ub300\uc751 \uba54\ucee4\ub2c8\uc998\u2019, \uc989 \uc548\ud2f0\uc13c\uc2a4RNA<\/span>\u00a0\ubd84\uc790\uac00\u00a0mRNA<\/span>\u00a0\ubd84\uc790\uc5d0 \ub2ec\ub77c\ubd99\uc5b4 \ubabb\uc4f0\uac8c \ud55c\ub2e4\ub294 \uac00\uc815\uc774 \ud2c0\ub9ac\ub2e4\ub294 \uc598\uae30\ub2e4. \uc774\ub97c \uc124\uba85\ud558\ub824\uba74 \ub123\uc5b4\uc900\u00a0RNA<\/span>\uac00 \ucd09\ub9e4\ucc98\ub7fc \uc2a4\uc2a4\ub85c\ub294 \uc18c\ubaa8\ub418\uc9c0 \uc54a\uc740 \ucc44 \uc0c1\ubcf4\uc801\uc778\u00a0mRNA<\/span>\ub97c \uacc4\uc18d\ud574\uc11c \ud30c\uad34\ud55c\ub2e4\uace0 \ubcfc \uc218\ubc16\uc5d0 \uc5c6\ub2e4. \ub530\ub77c\uc11c \uc5f0\uad6c\uc790\ub4e4\uc740 \uc774 \uacfc\uc815\uc5d0\uc11c \ubb54\uac00 \ubcf5\uc7a1\ud55c \uc2dc\uc2a4\ud15c\uc774 \ub3d9\uc6d0\ub41c\ub2e4\uace0 \uc8fc\uc7a5\ud588\ub2e4.<\/p>\n

\uc774 \uc5f0\uad6c\uacb0\uacfc\ub97c \ub2f4\uc740 \ub17c\ubb38\uc740 1998\ub144 2\uc6d4 19\uc77c\uc790 \u2018\ub124\uc774\ucc98\u2019\uc5d0 \uc2e4\ub838\uace0 \uc9c0\uae08\uae4c\uc9c0 1\ub9cc7000\ud68c \uac00\uae4c\uc774 \uc778\uc6a9\ub41c \u2018\uc804\uc124\u2019\uc774 \ub410\ub2e4.<\/p>\n

 <\/p>\n

<\/span><\/p>\n

1998\ub144 \ud559\uc220\uc9c0 \u2018\ub124\uc774\ucc98\u2019\uc5d0 \ubc1c\ud45c\ud55c \ub17c\ubb38\uc5d0\uc11c \uc564\ub4dc\ub8e8 \ud30c\uc774\uc5b4\uc640 \ud06c\ub808\uc774\uadf8 \uba5c\ub85c\ub294 \ud45c\uc801 \uc720\uc804\uc790\uc640 \uac19\uc740 \uc11c\uc5f4\uc778\u00a0RNA<\/span>(\uc13c\uc2a4)\ub098 \uc0c1\ubcf4\uc801\uc778 \uc11c\uc5f4\uc778\u00a0RNA<\/span>(\uc548\ud2f0\uc13c\uc2a4)\ub294 \ubc1c\ud604 \uc5b5\uc81c \ud6a8\uacfc\uac00 \uac70\uc758 \uc5c6\uace0\u00a0RNA<\/span>\uc774\uc911\uac00\ub2e5\uc774 \ud6a8\uacfc\uac00 \ud06c\ub2e4\ub294 \uc0ac\uc2e4\uc744 \ubc1c\uacac\ud588\ub2e4. \uadf8\ub9bc\uc740\u00a0unc<\/span>-22\uc720\uc804\uc790\ub97c \ub300\uc0c1\uc73c\ub85c \ud55c \uacb0\uacfc\ub85c,\u00a0RNA<\/span>\uc774\uc911\uac00\ub2e5\uc744 \ub123\uc5b4 \ubc1c\ud604\uc774 \ud06c\uac8c \ub5a8\uc5b4\uc9c4 \uacb0\uacfc \uc608\uc05c\uaf2c\ub9c8\uc120\ucda9\uc774 \uacbd\ub828\uc744 \uc77c\uc73c\ud0a8\ub2e4. – \ub178\ubca8\uc81c\ub2e8 \uc81c\uacf5\ufffd<\/em><\/span><\/p>\n

 <\/p>\n

 <\/p>\n

\uc0c8\ub85c\uc6b4 \uc720\uc804\uc790 \ubc1c\ud604 \uc870\uc808 \uc2dc\uc2a4\ud15c<\/strong><\/p>\n

\ud30c\uc774\uc5b4\uc640 \uba5c\ub85c\ub97c \ube44\ub86f\ud574 \uc5f0\uad6c\uc790\ub4e4\uc740 \ud6c4\uc18d \uc5f0\uad6c\ub97c \ud1b5\ud574 \uc774 \uc2dc\uc2a4\ud15c\uc758 \uc2e4\uccb4\ub97c \ubc1d\ud788\ub294 \ub370 \uc131\uacf5\ud588\ub2e4. \uc989 \uc138\ud3ec \uc548\uc73c\ub85c\u00a0RNA<\/span>\uc774\uc911\uac00\ub2e5\uc774 \ub4e4\uc5b4\uc624\uba74 \ub2e4\uc774\uc11c(Dicer<\/span>)\ub77c\ub294 \ub2e8\ubc31\uc9c8\ubcf5\ud569\uccb4\uc5d0\uc11c \uc5fc\uae30 20\uc5ec \uac1c \uae38\uc774\ub85c \uc798\ub9b0 \ub4a4 \ub610 \ub2e4\ub978 \ub2e8\ubc31\uc9c8\ubcf5\ud569\uccb4\uc778\u00a0RISC<\/span>\uc5d0\uc11c \ub2e8\uc77c\uac00\ub2e5(\uc548\ud2f0\uc13c\uc2a4)\ub9cc \ub0a8\ub294\ub2e4. \uc5ec\uae30\uc5d0 \ud45c\uc801\uc774 \ub418\ub294\u00a0mRNA<\/span>\uac00 \uc9c0\ub098\uac00\ub2e4 \uac78\ub9ac\uba74 \uc774\ub97c \ubd84\ud574\ud558\ub294 \ubc18\uc751\uc774 \uc77c\uc5b4\ub098\u00a0mRNA<\/span>\uac00 \ud30c\uad34\ub41c\ub2e4. \uc989 \uc9e7\uc740\u00a0RNA<\/span>\ub2e8\uc77c\uac00\ub2e5\uc774 \uac00\uc774\ub4dc \uc5ed\ud560\uc744 \ud558\ub294 \uc148\uc774\ub2e4. \uadf8\ub807\ub2e4\uba74 \uc65c \uc774\ucc98\ub7fc \ubc88\uac70\ub85c\uc6b4\u00a0RNA<\/span>\uac04\uc12d \uc2dc\uc2a4\ud15c\uc774 \uc874\uc7ac\ud558\ub294 \uac83\uc77c\uae4c.<\/p>\n

\ud30c\uc774\uc5b4\ub294 \ubc14\uc774\ub7ec\uc2a4\uc5d0 \ub300\ud55c \ubc29\uc5b4\uc2dc\uc2a4\ud15c\uc77c \uc218 \uc788\ub2e4\uace0 \uc81c\uc548\ud588\ub2e4. \uc989\u00a0RNA<\/span>\uc774\uc911\uac00\ub2e5 \uac8c\ub188\uc744 \uc9c0\ub2cc \ubc14\uc774\ub7ec\uc2a4\uac00 \uce68\ud22c\ud588\uc744 \uacbd\uc6b0 \ub2e4\uc774\uc11c\uac00 \ubc14\uc774\ub7ec\uc2a4 \uac8c\ub188\uc744 \ucc98\ub9ac\ud574\u00a0RISC<\/span>\uac00 \uc548\ud2f0\uc13c\uc2a4 \uc870\uac01\uc744 \uc9c0\ub2c8\uace0 \uc788\uc73c\uba74 \ubc14\uc774\ub7ec\uc2a4\uc758\u00a0mRNA<\/span>\ub97c \ud30c\uad34\ud574 \uc99d\uc2dd\uc744 \uc5b5\uc81c\ud560 \uc218 \uc788\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n

\uadf8\ub7f0\ub370 \uc774\ubcf4\ub2e4 5\ub144 \uc55e\uc120 1993\ub144 \ubc1c\uacac\ub41c \ub9c8\uc774\ud06c\ub85cRNA<\/span>(miRNA<\/span>) \uc5ed\uc2dc \ub3d9\uc77c\ud55c \uc2dc\uc2a4\ud15c\uc744 \uc774\uc6a9\ud574 \uc791\ub3d9\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ubc1d\ud600\uc84c\ub2e4.\u00a0miRNA<\/span>\ub294 \uc0dd\uba85\uccb4\uac00 \uc790\uc2e0\uc758 \uc720\uc804\uc790 \ubc1c\ud604\uc744 \uc870\uc808\ud558\uae30 \uc704\ud574 \ub9cc\ub4e4\uc5b4\ub0b4\ub294\u00a0RNA<\/span>\uac04\uc12d\uc774\uc5c8\ub358 \uc148\uc774\ub2e4. 2000\ub144\ub300 \ucd08\u00a0RNA<\/span>\uac04\uc12d\uc758 \uc2e4\uc0c1\uc774 \ub4dc\ub7ec\ub098\uba74\uc11c \uc0dd\uba85\uacfc\ud559\uc774\ub77c\ub294 \uc870\uac01\ud37c\uc990\uc758 \uc0c1\ub2f9 \ubd80\ubd84\uc774 \ud55c\uaebc\ubc88\uc5d0 \ub9de\ucdb0\uc84c\uae30 \ub54c\ubb38\uc5d0 2006\ub144 \uc11c\ub458\ub7ec \ub178\ubca8\uc0c1\uc774 \uc8fc\uc5b4\uc9c4 \uac83\uc774\ub2e4.<\/p>\n

RNA<\/span>\uac04\uc12d\uc740 \uc0dd\uba85\uacfc\ud559 \uc2e4\ud5d8\uc5d0 \ud070 \uc601\ud5a5\uc744 \ubbf8\ucce4\ub2e4. \uc989 \uc5b4\ub835\uc9c0 \uc54a\uac8c \ud2b9\uc815 \uc720\uc804\uc790\uc758 \ubc1c\ud604\uc744 80~90%\ub97c \uc5b5\uc81c\ud560 \uc218 \uc788\uac8c \ub418\uba74\uc11c(\uc774\ub97c \uc720\uc804\uc790 \ub179\ub2e4\uc6b4(knockdown<\/span>)\uc774\ub77c\uace0 \ubd80\ub978\ub2e4) \uadf8 \uc720\uc804\uc790\uc758 \uae30\ub2a5\uc744 \uaddc\uba85\ud560 \uc218 \uc788\uac8c \ub410\uae30 \ub54c\ubb38\uc774\ub2e4. \ud2b9\ud788 \uc720\uc804\uc790\ub97c \uc544\uc608 \uace0\uc7a5 \ub0b4\uba74(\uc774\ub97c \ub179\uc544\uc6c3(knockout<\/span>)\uc774\ub77c\uace0 \ubd80\ub978\ub2e4) \uc0dd\ubb3c\uc774 \ubc1c\uc0dd\uacfc\uc815\uc5d0\uc11c \uc8fd\uc744 \uacbd\uc6b0 \uadf8 \uae30\ub2a5\uc744 \uc54c \ubc29\ubc95\uc774 \uc5c6\ub294\ub370(\ubb34\ucc99 \uc911\uc694\ud560 \uac83\uc784\uc5d0\ub3c4), \ub179\ub2e4\uc6b4\uc774 \ud070 \ub3c4\uc6c0\uc774 \ub410\ub2e4.<\/p>\n

 <\/p>\n

<\/span><\/p>\n

2000\ub144\ub300 \ucd08\u00a0RNA<\/span>\uac04\uc12d\uc758 \ub300\ub7b5\uc801\uc778 \uc791\ub3d9 \uba54\ucee4\ub2c8\uc998\uc774 \ubc1d\ud600\uc84c\ub2e4. \uc774\uc5d0 \ub530\ub974\uba74\u00a0RNA<\/span>\uc774\uc911\uac00\ub2e5\uc5d0\uc11c\u00a0mRNA<\/span>\uc5d0 \uc0c1\ubcf4\uc801\uc778 \ub2e8\uc77c\uac00\ub2e5\uc774\u00a0RISC<\/span>\uc5d0 \uacb0\ud569\ub3fc\u00a0RISC<\/span>\uac00 \ud45c\uc801\uc778\u00a0mRNA<\/span>\ub97c \ud30c\uad34\ud558\ub294\ub370 \uac00\uc774\ub4dc \uc5ed\ud560\uc744 \ud55c\ub2e4. – \ub178\ubca8\uc7ac\ub2e8 \uc81c\uacf5<\/em><\/span><\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

\uc57d\ubb3c\uc804\ub2ec\uc2dc\uc2a4\ud15c \uac1c\ubc1c\uc774 \uad00\uac74<\/strong><\/p>\n

\uc544\uc6b8\ub7ec \ub9ce\uc740 \uc0ac\ub78c\ub4e4\uc774\u00a0RNA<\/span>\uac04\uc12d\uc758 \uc784\uc0c1 \uc801\uc6a9\uc73c\ub85c \uad00\uc2ec\uc744 \ub3cc\ub838\ub2e4. \ubc14\uc774\ub7ec\uc2a4\ub098 \uc554\uc758 \uc720\uc804\uc790\ub098 \uc720\uc804\uc9c8\ud658\uc744 \uc77c\uc73c\ud0a4\ub294 \ubcc0\uc774 \uc720\uc804\uc790\ub97c \ud45c\uc801\uc73c\ub85c \ud55c\u00a0RNA<\/span>\uac04\uc12d \uc57d\ubb3c\uc774 \ub098\uc628\ub2e4\uba74 \uc758\ud559\uacc4\uc5d0 \ud601\uba85\uc744 \ubab0\uace0 \uc62c \uc218 \uc788\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n

1970\ub144\ub300 \uc778\ud2b8\ub860(\uc720\uc804\uc790\uc5d0\uc11c \ub2e8\ubc31\uc9c8\uc758 \uc544\ubbf8\ub178\uc0b0\uc73c\ub85c \ubc88\uc5ed\uc774 \ub418\uc9c0 \uc54a\ub294 \ubd80\ubd84)\uc744 \ubc1c\uacac\ud574 1993\ub144 \ub178\ubca8\uc0dd\ub9ac\uc758\ud559\uc0c1\uc744 \ubc1b\uc740 \ud544\ub9bd \uc0e4\ud504\ub294 \ub3d9\ub8cc \uacfc\ud559\uc790\ub4e4\uacfc \ud22c\uc790\uc790\ub4e4\uc744 \ub04c\uc5b4\ubaa8\uc544 2002\ub144 \ubc14\uc774\uc624\ubca4\ucc98 \uc568\ub77c\uc774\ub78c\uc744 \uc124\ub9bd\ud588\ub2e4. \uc774\ub4e4\uc740\u00a0RNA<\/span>\uac04\uc12d\uc758 \uc7a0\uc7ac\ub825\uc744 \ub192\uc774 \ud3c9\uac00\ud558\uace0 \uc5f0\uad6c\uc5d0 \ub6f0\uc5b4\ub4e4\uc5c8\ub294\ub370 \uc5bc\ub9c8 \ubabb \uac00 \ub09c\uad00\uc5d0 \ubd80\ub52a\ud614\ub2e4.\u00a0RNA<\/span>\uc774\uc911\uac00\ub2e5\uc744 \ud45c\uc801\uc774 \ub418\ub294 \uc138\ud3ec\uae4c\uc9c0 \ubcf4\ub0b4\ub294 \uac8c \uc0dd\uac01\ubcf4\ub2e4 \uc5b4\ub824\uc6b4 \uc77c\uc774\ub77c\ub294 \uc0ac\uc2e4\uc774 \ub4dc\ub7ec\ub0ac\uae30 \ub54c\ubb38\uc774\ub2e4.<\/p>\n

RNA<\/span>\ub294 \uc124\uc0ac \uc774\uc911\uac00\ub2e5\uc77c\uc9c0\ub77c\ub3c4 \uaf64 \ubd88\uc548\uc815\ud55c \ubb3c\uc9c8\uc774\uace0 \ud608\uc561\uc5d0\ub294 \uc774\ub97c \uc778\uc2dd\ud574 \ud30c\uad34\ud558\ub294 \ud6a8\uc18c\uac00 \uc788\uae30 \ub54c\ubb38\uc5d0 \uadf8\ub300\ub85c\ub294 \uc57d\ubb3c\ub85c \uc4f8 \uc218 \uc5c6\ub2e4. \ubc14\uc774\ub7ec\uc2a4 \ucea1\uc290\uc5d0 \uc9d1\uc5b4\ub123\uc5b4(\uac8c\ub188 \uc870\uac01\uc758 \ud615\ud0dc\ub85c) \ud45c\uc801\uc774 \ub418\ub294 \uc138\ud3ec\uac00 \uc788\ub294 \uc870\uc9c1\uc744 \uac10\uc5fc\uc2dc\ud0a4\ub294 \ubc29\uc2dd\ub3c4 \ubb38\uc81c\uac00 \ub9ce\ub2e4.<\/p>\n

\uacb0\uad6d\u00a0RNA<\/span>\uc774\uc911\uac00\ub2e5\uc744 \uc798 \uac10\uc2f8\uc11c \ud45c\uc801\uc774 \ub418\ub294 \uc870\uc9c1\uc5d0 \uac08 \ub54c\uae4c\uc9c0 \ud30c\uad34\ub418\uc9c0 \uc54a\uac8c \ub9cc\ub4dc\ub294 \uc57d\ubb3c\uc804\ub2ec\uc2dc\uc2a4\ud15c \uac1c\ubc1c\uc5d0\u00a0RNA<\/span>\uc804\ub2ec \uc57d\ubb3c\uc758 \ubbf8\ub798\uac00 \uac78\ub824\uc788\ub2e4\ub294 \uc0ac\uc2e4\uc774 \ubd84\uba85\ud574\uc84c\ub2e4. \uc9c0\ub09c 10\ub144 \ub3d9\uc548 \uc568\ub77c\uc774\ub78c\uc744 \ube44\ub86f\ud574\u00a0RNA<\/span>\uac04\uc12d \uc57d\ubb3c\uc744 \uac1c\ubc1c\ud558\ub294 \ubca4\ucc98\ub4e4\uc740 \uc231\ud55c \uc2dc\ud589\ucc29\uc624\ub97c \uac70\uce58\uba70 \uc774 \uc5f0\uad6c\ub97c \ud574\uc654\uace0 \uc774\ubc88\uc5d0 \uc568\ub77c\uc774\ub78c\uc774 \ub9c8\uce68\ub0b4\u00a0RNA<\/span>\uac04\uc12d \uc2e0\uc57d \uc2b9\uc778\uc744 \ubc1b\uc740 \uac83\ub3c4 \uc81c\ub300\ub85c \uc791\ub3d9\ud558\ub294 \uc57d\ubb3c\uc804\ub2ec\uc2dc\uc2a4\ud15c\ub97c \uac1c\ubc1c\ud55c \ub355\ubd84\uc774\ub2e4.<\/p>\n

\uac04\ub2e8\ud788 \uc124\uba85\ud558\uba74\u00a0RNA<\/span>\uc774\uc911\ub098\uc120\uc744 \u2018\uc9c0\uc9c8\ub098\ub178\uc785\uc790(lipid<\/span>\u00a0nanoparticle<\/span>)\u2019 \uc548\uc5d0 \ub123\ub294 \uc57d\ubb3c\uc804\ub2ec\uc2dc\uc2a4\ud15c\uc774\ub2e4. \uc989 \ud45c\uba74\uc774 \uc74c\uc804\ud558\uc778\u00a0RNA<\/span>\uc774\uc911\ub098\uc120\uc744 \uc591\uc804\ud558\uc778 \uc9c0\uc9c8 \ubd84\uc790\ub85c \uac10\uc2fc \ub4a4 \uc774\ub97c \ub2e4\uc2dc \ud45c\uba74\ucc98\ub9ac\ub41c(\uc778\uccb4\uc758 \uba74\uc5ed\ubc18\uc751\uc744 \ud53c\ud558\uae30 \uc704\ud574) \uc9c0\uc9c8\ub85c \uac10\uc2f8 \uc9c0\ub984 50~100\ub098\ub178\ubbf8\ud130 \ud06c\uae30\uc758 \ub098\ub178\uc785\uc790\ub85c \ub9cc\ub4e0 \uac83\uc774\ub2e4.<\/p>\n

 <\/p>\n

<\/span><\/p>\n

RNA<\/span>\uac04\uc12d \uc57d\ubb3c\uc758 \ucd5c\ub300 \uac78\ub9bc\ub3cc\uc740 \ud45c\uc801\uc774 \ub418\ub294 \uc138\ud3ec\uae4c\uc9c0\u00a0RNA<\/span>\uc774\uc911\uac00\ub2e5\uc744 \ubcf4\ub0b4\ub294 \uc57d\ubb3c\uc804\ub2ec\uc2dc\uc2a4\ud15c\uc744 \ucc3e\ub294 \uc77c\uc774\ub2e4. \uc0dd\uccb4(\ud608\uc561) \ud6a8\uc18c \uc2dc\uc2a4\ud15c\uc73c\ub85c\ubd80\ud130\u00a0RNA<\/span>\uc774\uc911\uac00\ub2e5\uc744 \ubcf4\ud638\ud574\uc57c \ud560 \ubfd0 \uc544\ub2c8\ub77c \uba74\uc5ed\uacc4\uc758 \ud45c\uc801\uc774 \ub418\uc9c0 \uc54a\uc544\uc57c \ud558\uace0 \uc138\ud3ec\uc5d0 \ud761\uc218\ub41c \ub4a4\uc5d0\ub294 \ud574\uccb4\ub3fc \uc548\uc758 \uc57d\ubb3c(RNA<\/span>\uc774\uc911\uac00\ub2e5)\uc774 \ubc29\ucd9c\ub3fc\uc57c \ud55c\ub2e4. 10\uc5ec \ub144\uc758 \uace0\ud22c \ub05d\uc5d0 \ucc3e\uc544\ub0b8 \uc720\ub825\ud55c \uc57d\ubb3c\uc804\ub2ec\uc2dc\uc2a4\ud15c\uc778 \uc9c0\uc9c8\ub098\ub178\uc785\uc790\uc758 \uad6c\uc870\ub2e4. \uc774\ubc88\uc5d0 \uc2b9\uc778\uc744 \ubc1b\uc740 \ud30c\ud2f0\uc2dc\ub780\ub3c4 \uc774 \uc2dc\uc2a4\ud15c\uc744 \uc774\uc6a9\ud588\ub2e4. – \u2018\ub098\ub178\uc758\ud559\uad6d\uc81c\uc800\ub110\u2019 \uc81c\uacf5<\/em><\/span><\/p>\n

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\uc544\uc9c1\uc740 \uadf8\ub9bc\uc758 \ub5a1\uc774\uc9c0\ub9cc<\/strong><\/p>\n

\uc774\ubc88\uc5d0 \uc2b9\uc778\uc744 \ubc1b\uc740\u00a0RNA<\/span>\uac04\uc12d \uc57d\ubb3c \ud30c\ud2f0\uc2dc\ub780\uc740 \ubcc0\uc774 \ud2b8\ub79c\uc2a4\ud2f0\ub808\ud2f4(transthyretin<\/span>)\uc758\u00a0mRNA<\/span>\ub97c \ud30c\uad34\ud574 \uc138\ud3ec \ub0b4\uc5d0 \ubcc0\uc774 \ud2b8\ub79c\uc2a4\ud2f0\ub80c\uc2a4 \ub2e8\ubc31\uc9c8\uc774 \ucd95\uc801\ub418\uc9c0 \ubabb\ud558\uac8c \ud574 \uc57d\ud6a8\ub97c \ub0b8\ub2e4. \uc774\uac8c \uc313\uc774\ub294 \uc544\ubc00\ub85c\uc774\ub4dc\uc99d(amyloidosis<\/span>)\uc740 \uc138\uacc4\uc5d0 \ud658\uc790 \uc218\uac00 5\ub9cc\uc5ec \uba85\uc778 \ud76c\uadc0\ubcd1\uc73c\ub85c \ubc1c\ubcd1\ud558\uba74 \uc218\ub144 \ub0b4 \uc0ac\ub9dd\ud55c\ub2e4. \uc989 \uac04\uc5d0\uc11c \ub9cc\ub4e4\uc5b4\uc9c4 \ubcc0\uc774 \ud2b8\ub79c\uc2a4\ud2f0\ub808\ud2f4 \ub2e8\ubc31\uc9c8\uc774 \uc5ec\ub7ec \uc870\uc9c1\uc5d0 \ucd95\uc801\ub3fc \ub9d0\ucd08\uc2e0\uacbd\ubcd1\uc99d \ub4f1\uc744 \uc720\ubc1c\ud55c\ub2e4.<\/p>\n

\ud30c\ud2f0\uc2dc\ub780\uc740 3\uc8fc \uac04\uaca9\uc73c\ub85c \ud22c\uc57d\ud558\ub294\ub370 \uc568\ub77c\uc774\ub78c\uc774 \uc81c\uc2dc\ud55c \uc57d\uac12\uc73c\ub85c \uacc4\uc0b0\ud558\uba74 1\ub144 \uce58\ub8cc\ube44\uac00 \ubb34\ub824 35\ub9cc \ub2ec\ub7ec(\uc57d 4\uc5b5 \uc6d0)\uc5d0 \uc774\ub978\ub2e4. \ud22c\uc57d\uc744 \ub04a\uc73c\uba74 \ub2e4\uc2dc \ubcc0\uc774 \ub2e8\ubc31\uc9c8\uc774 \uc313\uc774\ubbc0\ub85c \uacb0\uad6d \ud3c9\uc0dd \ud22c\uc57d\ud574\uc57c \ud55c\ub2e4\ub294 \ub9d0\uc778\ub370 \uac11\ubd80\uac00 \uc544\ub2cc \ub2e4\uc74c\uc5d0\uc57c \uac10\ub2f9\uc774 \uc548 \ub418\ub294 \uc218\uc900\uc774\ub2e4(\uc758\ub8cc\ubcf4\ud5d8\uc774 \uc801\uc6a9\ub418\uba74 \ub2ec\ub77c\uc9c0\uaca0\uc9c0\ub9cc).<\/p>\n

\ud558\uc9c0\ub9cc \uc55e\uc73c\ub85c\ub3c4\u00a0RNA<\/span>\uac04\uc12d \uc57d\ubb3c\uc774 \uc774\ucc98\ub7fc \u2018\uadf8\ub9bc\uc758 \ub5a1\u2019\uc77c \uac00\ub2a5\uc131\uc740 \ub0ae\ub2e4. \uc5ec\ub7ec \uc5c5\uccb4\uc5d0\uc11c \uc57d\ubb3c\uc774 \ub098\uc624\uae30 \uc2dc\uc791\ud558\uace0 \uc81c\uc870\uc2dc\uc2a4\ud15c\uc774 \ucd5c\uc801\ud654\ub418\uba74 \uac12\uc740 \ube60\ub974\uac8c \ub5a8\uc5b4\uc9c8 \uac83\uc774\ub2e4. \ud544\uc790\ub294 \uac1c\uc778\uc801\uc73c\ub85c \ubcc0\uc774 \uc720\uc804\uc790 \uc9c8\ud658 \uce58\ub8cc\uc81c\ubcf4\ub2e4\ub294 \ud56d\ubc14\uc774\ub7ec\uc2a4\uc81c\ub098 \ud56d\uc554\uc81c \ucabd\uc744 \ub354 \uae30\ub300\ud558\uace0 \uc788\ub2e4.<\/p>\n

\uc774\ub4e4\uc774 \ubcc0\uc774\ub97c \uc77c\uc73c\ucf1c\u00a0RNA<\/span>\uac04\uc12d \uc57d\ubb3c\uc5d0 \ub0b4\uc131\uc744 \uac16\uac8c \ub3fc\ub3c4 \uadf8\uc5d0 \ub300\uc751\ud574\u00a0RNA<\/span>\uc758 \uc5fc\uae30\uc11c\uc5f4\ub9cc \ubc14\uafd4\uc8fc\uba74 \uc27d\uac8c \uadf9\ubcf5\ud560 \uc218 \uc788\uae30 \ub54c\ubb38\uc774\ub2e4. \uc774\ub294 \ub2e8\ubc31\uc9c8\uc744 \ud45c\uc801\uc73c\ub85c \ud558\ub294 \uc57d\ubb3c\uc5d0\uc11c\ub294 \uad6c\ud604\ub420 \uc218 \uc5c6\ub294 \uc774\uc810\uc774\ub2e4.<\/p>\n

 <\/p>\n

<\/span><\/p>\n

\uc720\uc804\uc131 \ud2b8\ub79c\uc2a4\ud2f0\ub808\ud2f4 \uc544\ubc00\ub85c\uc774\ub4dc\uc99d \uce58\ub8cc\uc81c\uc778 \ud30c\ud2f0\uc2dc\ub780\uc758 \uc791\ub3d9 \uba54\ucee4\ub2c8\uc998\uc744 \ub3c4\uc2dd\ud654\ud55c \uadf8\ub9bc\uc774\ub2e4. \ud30c\ud2f0\uc2dc\ub780\uc744 \uc815\ub9e5\ud22c\uc5ec\ud558\uba74(a)\u00a0RNA<\/span>\uc774\uc911\ub098\uc120\uc774 \ub4e4\uc5b4\uc788\ub294 \uc9c0\uc9c8\ub098\ub178\uc785\uc790\uac00 \ud608\uad00\uc744 \ud0c0\uace0 \ub2e4\ub2c8\ub2e4 \ud45c\uc801\uc778 \uac04\uc138\ud3ec\ub85c \ub4e4\uc5b4\uac04\ub2e4(b. \ub098\ub178\uc785\uc790 \ud45c\uba74\uc5d0\u00a0ApoE<\/span>\u00a0\ub2e8\ubc31\uc9c8\uc744 \ubd99\uc5ec \uac04\uc138\ud3ec \ud45c\uba74\uc758\u00a0ApoE<\/span>\u00a0\uc218\uc6a9\uccb4\uc5d0 \ub2ec\ub77c\ubd99\uac8c \ud588\ub2e4). \uc138\ud3ec \uc548\uc5d0\uc11c \ub098\ub178\uc785\uc790\uac00 \ud574\uccb4\ub418\uba70(c)\u00a0RNA<\/span>\uc774\uc911\uac00\ub2e5\uc774 \ube60\uc838\ub098\uc640 \ub2e4\uc774\uc11c\uc5d0\uc11c \uac00\uacf5\ub41c \ub4a4 \ud45c\uc801\uc778 \ubcc0\uc774 \ud2b8\ub79c\uc2a4\ud2f0\ub808\ud2f4(TTR<\/span>)\u00a0mRNA<\/span>\uc640 \uc0c1\ubcf4\uc801\uc778 \ub2e8\uc77c\uac00\ub2e5\uc774\u00a0RICS<\/span>\uc5d0 \uacb0\ud569\ub3fc\u00a0TTR<\/span>\u00a0mRNA<\/span>\ub97c \ud30c\uad34\ud55c\ub2e4(d). \ud45c\uc801\uc778 \ubcc0\uc774 \ud2b8\ub79c\uc2a4\ud2f0\ub808\ud2f4(TTR<\/span>)\u00a0mRNA<\/span>\uc640 \uc0c1\ubcf4\uc801\uc778 \ub2e8\uc77c\uac00\ub2e5\uc774\u00a0RICS<\/span>\uc5d0 \uacb0\ud569\ub3fc\u00a0TTR<\/span>\u00a0mRNA<\/span>\ub97c \ud30c\uad34\ud55c\ub2e4(d). \uadf8 \uacb0\uacfc \ubcc0\uc774 \ub2e8\ubc31\uc9c8\uc774 \ucd95\uc801\ub418\uc9c0 \uc54a\uc544 \uc544\ubc00\ub85c\uc774\ub4dc\uc99d\uc774 \uac1c\uc120\ub41c\ub2e4(e). \u2018Pharmaceutical<\/span>\u00a0Research<\/span>\u2019 \uc81c\uacf5<\/em><\/span><\/p>\n

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\ub18d\uc57d \ub0b4\uc131 \uadf9\ubcf5\ud560 \ub300\uc548\uc73c\ub85c \ub5a0\uc62c\ub77c<\/strong><\/p>\n

\ud55c\ud3b8 \uc568\ub77c\uc774\ub78c\uc740 \uc9c0\ub09c 2012\ub144 \uac70\ub300 \ub18d\uc57d\ud68c\uc0ac \ubaac\uc0b0\ud1a0\uc640 10\ub144\uc9dc\ub9ac \ud611\uc57d\uc744 \ub9fa\uc5b4\u00a0RNA<\/span>\uac04\uc12d \ub18d\uc57d\uc744 \uac1c\ubc1c\ud558\uace0 \uc788\ub2e4. \uc624\ub298\ub0a0 \ub18d\uc57d, \uc989 \uc0b4\ucda9\uc81c\uc640 \uc81c\ucd08\uc81c\ub294 \ub0b4\uc131\uc774\ub77c\ub294 \uc704\uae30\ub97c \ub9de\uace0 \uc788\ub2e4. \uc989 \uc544\ubb34\ub9ac \uc57d\uc744 \uccd0\ub3c4 \ud574\ucda9\uc774\ub098 \uc7a1\ucd08\uac00 \uc798 \uc8fd\uc9c0 \uc54a\ub294\ub2e4.<\/p>\n

\uc774\uc5d0 \ub300\ud55c \ub300\uc751\uc73c\ub85c \ud574\ucda9\uc758 \uc720\uc804\uc790\ub97c \ud45c\uc801\uc73c\ub85c \ud55c\u00a0RNA<\/span>\uac00\ub2e5\uc744 \ub9cc\ub4e4\uc5b4 \uc0b4\ucda9\uc81c\ub85c \uc4f4\ub2e4\ub294 \uc804\ub7b5\uc774 \ubd80\uc0c1\ud588\ub2e4. \uc778\uac04\uc138\ud3ec\uc5d0\u00a0RNA<\/span>\uc870\uac01\uc744 \ub123\ub294 \uc77c\uc740 \uaf64 \uae4c\ub2e4\ub86d\uc9c0\ub9cc \uc808\uc9c0\ub3d9\ubb3c\uc758 \uacbd\uc6b0\ub294\u00a0RNA<\/span>\ub97c \uba39\uc774\uba74 \uc7a5\uc5d0\uc11c \uc27d\uac8c \ud761\uc218\ub418\ub294 \uac83\uc73c\ub85c \ubc1d\ud600\uc84c\uae30 \ub54c\ubb38\uc774\ub2e4. \ub18d\uc791\ubb3c\uc5d0 \ub18d\uc57d\uc744 \uce58\ub4ef\u00a0RNA<\/span>\uc870\uac01\uc774 \ub4e0 \ubb3c\uc744 \ubfcc\ub824\uc8fc\uba74 \uc2dd\ubb3c\uc774 \ubfcc\ub9ac\ub85c \ud761\uc218\ud558\uace0 \uc774\ub97c \uba39\uc740 \ud574\ucda9\uc774\u00a0RNA<\/span>\uac04\uc12d\uc73c\ub85c \uc8fd\uac8c \ub41c\ub2e4.<\/p>\n

RNA<\/span>\uac04\uc12d\uc774 \uae30\ub300\ub97c \ubc1b\ub294 \uc774\uc720\ub294 \ud2b9\uc815 \uc5fc\uae30\uc11c\uc5f4\uc744 \ud45c\uc801\uc73c\ub85c \ud558\uae30 \ub54c\ubb38\uc5d0 \ub2e4\ub978 \uc0dd\ubb3c\uccb4\uc5d0 \ud574\ub97c \ub07c\uce60 \uac00\ub2a5\uc131\uc774 \ub0ae\uae30 \ub54c\ubb38\uc774\ub2e4. \ub610 \ud574\ucda9\uc774 \ub0b4\uc131\uc744 \ud68d\ub4dd\ud560 \uacbd\uc6b0 \ubcc0\uc774\uc5d0 \ub9de\ucdb0\u00a0RNA<\/span>\uac00\ub2e5\uc744 \uc0c8\ub85c \ub9cc\ub4e4\uba74 \ub418\ubbc0\ub85c \ud574\ucda9\uc73c\ub85c\uc11c\ub294 \uc8fd\uc744 \ub9db\uc774\ub2e4.<\/p>\n

\uc568\ub77c\uc774\ub78c\uacfc \ubaac\uc0b0\ud1a0\ub294 \uafc0\ubc8c\uc758 \ud574\ucda9\uc778 \uc9c4\ub4dc\uae30(\ud559\uba85\u00a0Verroa<\/span>\u00a0destructor<\/span>)\uc640 \uc720\ucc44\ub97c \uacf5\uaca9\ud558\ub294 \ubcbc\ub8e9\uc78e\ubc8c\ub808\ub97c \ud45c\uc801\uc73c\ub85c \ud558\ub294\u00a0RNA<\/span>\uac04\uc12d \uc0b4\ucda9\uc81c\ub97c \uac1c\ubc1c\ud558\uace0 \uc788\ub294\ub370 2020\ub144 \uc2dc\uc7a5\uc5d0 \ub098\uc62c \uac83\uc73c\ub85c \uc608\uc0c1\ud558\uace0 \uc788\ub2e4. \ud55c\ud3b8 \ub610 \ub2e4\ub978 \uac70\ub300 \ub18d\uc57d\ud68c\uc0ac\uc778 \uc2e0\uc820\ud0c0\ub294 \ucf5c\ub85c\ub77c\ub3c4\uac10\uc790\uc78e\ubc8c\ub808\ub97c \ub300\uc0c1\uc73c\ub85c\u00a0RNA<\/span>\uac04\uc12d \uc0b4\ucda9\uc81c\ub97c \uac1c\ubc1c\ud558\uace0 \uc788\ub294\ub370 \uc5ed\uc2dc 2020\ub144 \ucd9c\uc2dc\ub97c \ubaa9\ud45c\ub85c \ud558\uace0 \uc788\ub2e4.<\/p>\n

RNA<\/span>\uac04\uc12d\uc774 \uc758\ud559\uacfc \ub18d\uc5c5\uc5d0 \uc5bc\ub9c8\ub098 \ud070 \ud30c\uc7a5\uc744 \ubd88\ub7ec\uc77c\uc73c\ud0ac\uc9c0 \uae30\ub300\uac00 \ud06c\ub2e4.<\/p>\n

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http:\/\/www.sedaily.com\/NewsView\/1S4O8I1RHV<\/p>\n

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\ud2b9\uc815 \uc720\uc804\uc790 \ubc1c\ud604 \uc790\uccb4\ub97c \uc5b5\uc81c
\n\ud76c\uadc0\uc9c8\ud658 \uce58\ub8cc\uc81c\ub85c \ubb34\ud55c \uac00\ub2a5\uc131
\n\uc9c4\uc6d0\uc0dd\uba85\uacfc\ud559, \uae30\uc220 \uc774\uc804 \uacc4\uc57d
\n\uc62c\ub9ad\uc2a4\ub3c4 \u7f8e\uc11c \uac1c\ubc1c\ucc45\uc784\uc790 \uc601\uc785<\/strong><\/p>\n

 <\/p>\n

\ub9ac\ubcf4\ud575\uc0b0(RNA<\/span>)\uc73c\ub85c \uc9c8\ubcd1 \ubc1c\ud604 \uc720\uc804\uc790\ub97c \uc6d0\ucc9c \ucc28\ub2e8\ud558\ub294\u00a0RNA<\/span>\u00a0\uac04\uc12d(RNAi<\/span>) \uce58\ub8cc\uc81c\uac00 \ucc28\uc138\ub300 \ubc14\uc774\uc624\uc758\uc57d\ud488\uc73c\ub85c \uc8fc\ubaa9 \ubc1b\uc73c\uba74\uc11c \uad6d\ub0b4 \ubc14\uc774\uc624\ubca4\ucc98\ub4e4\uc774 \uc2e0\uc57d \uac1c\ubc1c\uc5d0 \ub6f0\uc5b4\ub4e4\uace0 \uc788\ub2e4. \uc774\ub4e4\u00a0RNAi<\/span>\u00a0\uce58\ub8cc\uc81c\ub294 \ub2e8\ubc31\uc9c8\uc744 \ud1b5\ud574 \uc9c8\ubcd1 \uc720\ubc1c \uc778\uc790\ub97c \uc81c\uac70\ud558\ub294 \uae30\uc874 \ubc14\uc774\uc624\uc758\uc57d\ud488\ubcf4\ub2e4 \ud55c \ub2e8\uacc4 \ub354 \ubc1c\uc804\ud55c \ud615\ud0dc\ub85c \uc9c8\ubcd1 \uc720\ubc1c \uc778\uc790 \uc790\uccb4\uac00 \ud65c\uc131\ud654\ub418\uc9c0 \ubabb\ud558\ub3c4\ub85d\u00a0RNA<\/span>\u00a0\ucc28\uc6d0\uc5d0\uc11c \uc81c\uac70\ud558\ub294 \uae30\uc220\uc774\ub2e4.<\/p>\n

\uc9c4\uc6d0\uc0dd\uba85\uacfc\ud559\uc740 17\uc77c \u201c\ubbf8\uad6d \ud734\uc2a4\ud134 \ub9e4\uc18c\ub514\uc2a4\ud2b8 \ubcd1\uc6d0 \uc5f0\uad6c\uc18c\uc640\u00a0mRNA<\/span>\u00a0\ubc31\uc2e0\uc124\uacc4 \ubc0f \uc5f0\uad6c\uae30\uc220\uc744 \uc774\uc804\ubc1b\ub294 \ub3c5\uc810\uc801 \ub77c\uc774\uc120\uc2a4 \uacc4\uc57d\uc744 \uccb4\uacb0\ud588\ub2e4\u201d\uace0 \ubc1d\ud614\ub2e4.<\/p>\n

 <\/p>\n

<\/span><\/p>\n

 <\/p>\n

\uc774 \ud68c\uc0ac \ubc15\uc601\uadfc \ub300\ud45c\ub294 \u201c\uc774\ubc88 \uacc4\uc57d\uc744 \ud1b5\ud574\u00a0DNA<\/span>\u00a0\ubc31\uc2e0 \ubc0f \uce58\ub8cc\uc81c \ubfd0 \uc544\ub2c8\ub77c\u00a0mRNA<\/span>\u00a0\ubc31\uc2e0 \ubc0f\u00a0RNA<\/span>\u00a0\uce58\ub8cc\uc81c\uc5d0\ub3c4 \uc9c4\ucd9c\ud558\uac8c \ub410\ub2e4\u201d\uba70 \u201c\ud575\uc0b0 \uae30\ubc18 \uc758\uc57d\ud488 \uc804\ubb38\uae30\uc5c5\uc73c\ub85c \uc2dc\ub108\uc9c0\ud6a8\uacfc\ub97c \ucc3d\ucd9c\ud558\uaca0\ub2e4\u201d\uace0 \ub367\ubd99\uc600\ub2e4.<\/p>\n

\uc2e0\uc57d\uac1c\ubc1c\uae30\uc5c5 \uc62c\ub9ad\uc2a4\ub3c4 \uc774\ub0a0 \ubcf4\uc2a4\ud134 \ubc14\uc774\uc624\uba54\ub514\uceec \ucd9c\uc2e0 \uc6e8\uc774 \ub9ac \ucd5c\uace0\uac1c\ubc1c\ucc45\uc784\uc790(CD<\/span>0)\ub97c \uc601\uc785\ud588\ub2e4\uace0 \uc804\ud588\ub2e4. \uc6e8\uc774 \ub9ac\u00a0CDO<\/span>\ub294 \ubcf4\uc2a4\ud134 \ubc14\uc774\uc624\uba54\ub514\uceec\uc5d0\uc11c 11\ub144\uac04 \ubd80\uc0ac\uc7a5\uc73c\ub85c \ud65c\ub3d9\ud588\ub358 \uacbd\ud5d8\uc744 \ubc14\ud0d5\uc73c\ub85c \uc62c\ub9ad\uc2a4\uc758 \uc0ac\uc5c5\uac1c\ubc1c\uc744 \ub2f4\ub2f9\ud560 \uc608\uc815\uc774\ub2e4. \uc774\uc5d0 \uc55e\uc11c \uc774\ub3d9\uae30 \uc62c\ub9ad\uc2a4 \ub300\ud45c\ub294 \uc9c0\ub09c 7\uc77c \u201c\uace7\u00a0RNAi<\/span>\u00a0\uc2e0\uc57d(OLX<\/span>10010)\uc758 \uad6d\ub0b4 \uc784\uc0c1 2\uc0c1\uc744 \uc9c4\ud589\ud560 \uac83\uc774\uba70 \uc608\uc815\ub300\ub85c \uac1c\ubc1c \uc808\ucc28\uac00 \uc774\ub904\uc9c0\uba74 2022\ub144\uc5d0 \uc2e0\uc57d\uc744 \ucd9c\uc2dc\ud560 \uc218 \uc788\uc744 \uac83\u201d\uc774\ub77c \ubc1d\ud614\ub2e4.<\/p>\n

RNA<\/span>\ub294\u00a0DNA<\/span>\uc640 \ud568\uaed8 \ub2e8\ubc31\uc9c8\uc758 \uc124\uacc4\ub3c4 \uc5ed\ud560\uc744 \ub9e1\ub294\ub2e4. \uc678\ubd80\uc758 \ucda9\uaca9\uc5d0 \uc548\uc815\uc801\uc778\u00a0DNA<\/span>\uc640 \ub2ec\ub9ac\u00a0RNA<\/span>\ub294 \ubbf8\uc138\ud55c \ud658\uacbd \ubcc0\ud654\uc5d0\ub3c4 \ubcc0\uc774\uac00 \uc77c\uc5b4\ub098\uae30 \uc27d\ub2e4. \uc911\ub3d9\ud638\ud761\uae30\uc99d\ud6c4\uad70(MERS<\/span>\u00b7\uba54\ub974\uc2a4)\uc744 \uc720\ubc1c\ud558\ub294 \ucf54\ub85c\ub098\ubc14\uc774\ub7ec\uc2a4(MERS<\/span>–CoV<\/span>)\uc640 \uac19\uc740 \ubcd1\uc6d0\uc131 \ubc14\uc774\ub7ec\uc2a4\ub4e4\uc740 \uc774\ub7f0 \ud5c8\uc810\uc744 \uc774\uc6a9\ud55c\ub2e4. \uc6b0\ub9ac \ubab8\uc5d0\uc11c \ub9cc\ub4e4\uc5b4\ub0b4\ub824\ub294 \uc124\uacc4\ub3c4\uc5d0 \ubc14\uc774\ub7ec\uc2a4\uac00 \uc6d0\ud558\ub294 \ubb3c\uc9c8\uc744 \ub07c\uc6cc \ub123\uc5b4 \uc219\uc8fc\uc758 \ubab8\uc744 \uac10\uc5fc\ud558\uace0 \ub2e4\ub978 \uc219\uc8fc\ub85c \ubc14\uc774\ub7ec\uc2a4\ub97c \uc804\ud30c\ud55c\ub2e4.\u00a0RNA<\/span>\uac04\uc12d\uc740 \uc774\ub7ec\ud55c \uacfc\uc815\uc744 \u2018\uac04\uc12d\u2019\ud574 \ubc14\uc774\ub7ec\uc2a4\uac00 \uae30\ub300\ud558\ub294 \ub2e8\ubc31\uc9c8\uc744 \ub9c9\ub294 \ubc29\ubc95\uc774\ub2e4. \uccb4\ub0b4\uc5d0 \uc8fc\uc785\ud558\ub294 \uac83\ub9cc\uc73c\ub85c \ud2b9\uc815 \uc720\uc804\uc790\uc758 \ud65c\uc131\uc744 \ub9c9\uc544 \uc9c8\ubcd1\uc744 \uce58\ub8cc\ud560 \uc218 \uc788\ub2e4.<\/p>\n

RNA<\/span>\u00a0\uae30\ubc18 \uce58\ub8cc\uc81c\ub294 \ub2e8\ubc31\uc9c8\uc5d0 \uc791\uc6a9\ud558\ub294 \uae30\uc874 \ubc14\uc774\uc624\uc758\uc57d\ud488\uacfc \ub2ec\ub9ac \ub2e8\ubc31\uc9c8 \uc0dd\uc131 \uc774\uc804 \ub2e8\uacc4\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ub9cc\ud07c \uae30\uc874 \uae30\uc220\ub85c \ud45c\uc801\uc774 \ubd88\uac00\ub2a5\ud588\ub358 \uc2e0\uc57d \uac1c\ubc1c\uc774 \uac00\ub2a5\ud558\ub2e4. \uc544\uc6b8\ub7ec \uce58\ub8cc\uc81c\uac00 \uac1c\ubc1c\ub41c \uc9c0 \uc5bc\ub9c8 \ub418\uc9c0 \uc54a\uc740 \ub9cc\ud07c \ubc1c\uc804 \uac00\ub2a5\uc131\uc774 \ubb34\uad81\ubb34\uc9c4\ud558\ub2e4.\u00a0RNA<\/span>\u00a0\uac04\uc12d \ud604\uc0c1\uc744 \uc774\uc6a9\ud55c \ucd5c\ucd08\uc758 \uce58\ub8cc\uc81c\uc778 \uc568\ub098\uc774\ub78c \ud30c\ub9c8\uc288\ud2f0\uceec\uc988\uc758 \u2018\uc628\ud30c\ud2b8\ub85c\u2019\ub294 \uc9c0\ub09c\ub2ec 10\uc77c \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(FDA<\/span>) \ud5c8\uac00\ub97c \ubc1b\uc558\ub2e4.\u00a0RNAi<\/span>\u00a0\uae30\ubc18 \uae30\uc220\uc744 \uac16\ucd98 \uad6d\ub0b4 \uae30\uc5c5\uc73c\ub85c \uc62c\ub9ad\uc2a4 \uc678\uc5d0\ub3c4 \uc62c\ub9ac\ud328\uc2a4, \ubc14\uc774\uc624\ub2c8\uc544 \ub4f1\uc774 \uc788\ub2e4. \ubc14\uc774\uc624\ub2c8\uc544\ub294 \ud2b9\ubc1c\uc131 \ud3d0\uc12c\uc720\ud654\uc99d \ubc0f \ud3d0\uc554 \uce58\ub8cc\uc81c\ub97c \uc804\uc784\uc0c1\uc911\uc774\ub2e4. \uc62c\ub9ac\ud328\uc2a4\ub294 \ud1b5\uc99d\uce58\ub8cc\uc81c \u2018SCN<\/span>9A\u2019\ub97c \uac1c\ubc1c \uc911\uc774\ub2e4.<\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

    \ub4dc\ub514\uc5b4 RNAi \uae30\ubc18\uc758 \uc57d\uc774 FDA \uc2b9\uc778\uc744 \ubc1b\uc558\uad70\uc694^^     (\uc6d0\ubb38)       The US Food and Drug Administration\u2019s decision breathes new life(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[33,34,29,30,47],"tags":[7,8,3,4],"class_list":["post-1360","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-chemistry","category-lets-do-science","category-recent-science-news","category-47","tag-do-biology","tag-lets-do-chemistry","tag-lets-do-science","tag-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":4481,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4481","url_meta":{"origin":1360,"position":0},"title":"RNA therapies explained","author":"biochemistry","date":"October 18, 2019","format":false,"excerpt":"\u00a0 Treatments that target RNA or deliver it to cells fall into three broad categories, with hybrid approaches also emerging. \u00a0 \u00a0 Illustration of messenger RNA (red) produced from a DNA strand (purple).\u00a0Credit: Juan Gaertner\/SPL \u00a0 \u00a0 The conventional view of RNA casts the molecule in a supporting role \u2014\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":4483,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4483","url_meta":{"origin":1360,"position":1},"title":"Pharma\u2019s roller-coaster relationship with RNA therapies","author":"biochemistry","date":"October 18, 2019","format":false,"excerpt":"\u00a0 \u00a0 After a groundswell of hype and a sceptical backlash, the pharmaceutical industry is learning how to leverage RNA interference in the clinic. \u00a0 \u00a0 Credit: Neil Webb \u00a0 Fortunes can shift precipitously in the drug-discovery world. 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