\uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n <\/p>\n
<\/p>\n
\ubc14\uc774\uc624 \uc2e0\uae30\uc220 \uc5f0\uad6c \ud65c\ubc1c<\/p>\n
CAR<\/span>-T \uc784\uc0c1 \u7f8e \uc774\uc5b4 2\uc704
\n\ud06c\ub9ac\uc2a4\ud37c \uc720\uc804\uc790\uac00\uc704\ub294 \ub3c5\ubcf4\uc801
\n\ud55c\uad6d\uc740 \uc0dd\uba85\uc724\ub9ac\ubc95 \ub9c9\ud600 0\uac74
\n\uc904\uae30\uc138\ud3ec \ubd84\uc57c\ub3c4 \uc5ed\uc804 \uc704\uae30<\/p>\n\u4e2d, \uc758\uc57d\ud488\u00a0CMO<\/span>\uc2dc\uc124 \uacf5\uaca9 \ud655\ub300<\/p>\n <\/p>\n
![](\"https:\/\/imgnews.pstatic.net\/image\/015\/2018\/08\/08\/0003992752_001_20180809011209782.jpg?type=w647\")
<\/span><\/p>\n\uc6b0\uc2dc\ubc14\uc774\uc624\ub85c\uc9c1\uc2a4\uc758 \ud55c \uc9c1\uc6d0\uc774 \ubc14\uc774\uc624\uc758\uc57d\ud488 \uc81c\uc870 \uacf5\uc815\uc744 \ud655\uc778\ud558\uace0 \uc788\ub2e4. \/\ud55c\uacbdDB<\/span><\/em><\/span><\/p>\n <\/p>\n
<\/p>\n
\uc9c0\ub09c\ud574 6\uc6d4 \uc911\uad6d\uc758 \uc791\uc740 \ubc14\uc774\uc624 \ubca4\ucc98\uae30\uc5c5\uc774 \ubbf8\uad6d\uc784\uc0c1\uc885\uc591\ud559\ud68c(ASCO<\/span>)\uc5d0\uc11c \ubc1c\ud45c\ud55c \uc784\uc0c1 \uacb0\uacfc\uc5d0 \uc138\uacc4 \uc81c\uc57d\uc5c5\uacc4\uac00 \ub4e4\uc369\ud588\ub2e4. \uc774 \ud68c\uc0ac\uac00 \uac1c\ubc1c \uc911\uc778\u00a0CAR<\/span>-T(\ud0a4\uba54\ub77c \ud56d\uc6d0 \uc218\uc6a9\uccb4) \uce58\ub8cc\uc81c\ub97c \ub2e4\ubc1c\uace8\uc218\uc885 \ud658\uc790\uc5d0\uac8c \ud22c\uc5ec\ud588\ub354\ub2c8 94%\uc5d0\uac8c\uc11c \ud6a8\uacfc\uac00 \ub098\ud0c0\ub0ac\ub2e4\ub294 \ub0b4\uc6a9\uc774\uc5c8\ub2e4. \uadf8\ub85c\ubd80\ud130 6\uac1c\uc6d4 \ub4a4 \ubbf8\uad6d \uc874\uc2a8\uc564\ub4dc\uc874\uc2a8\uc740 \uc774 \ud68c\uc0ac\uc5d0 3\uc5b55000\ub9cc\ub2ec\ub7ec(\uc57d 3800\uc5b5\uc6d0)\ub97c \ud22c\uc790\ud588\ub2e4. \ub09c\uc9d5 \ub808\uc804\ub4dc\ubc14\uc774\uc624\ud14d\uc758 \uc598\uae30\ub2e4. \uc6d4\uc2a4\ud2b8\ub9ac\ud2b8\uc800\ub110\uc740 \uc9c0\ub09c 5\uc77c \u2018\uc911\uad6d\uc774 \uc5b4\ub5bb\uac8c \ubcf5\uc81c\uc57d \uacf5\uc7a5\uc5d0\uc11c \uc2e0\uc57d \uac1c\ubc1c\uad6d\uac00\ub85c \uc9c4\ud654\ud588\ub098\u2019\ub77c\ub294 \uae30\uc0ac\uc5d0\uc11c \uc774 \ud68c\uc0ac\uc758 \uc0ac\ub840\ub97c \uc18c\uac1c\ud588\ub2e4.<\/p>\n\ub808\uc804\ub4dc\ubc14\uc774\uc624\ud14d\uc740 \uc9c0\ub09c 5\uc6d4 \ubbf8\uad6d \uc2dd\ud488\uc758\uc57d\uad6d(FDA<\/span>)\uc758 \uc784\uc0c1 \uc2b9\uc778\uc744 \ubc1b\uc558\uace0 \uc874\uc2a8\uc564\ub4dc\uc874\uc2a8\uacfc\u00a0CAR<\/span>-T \ud6c4\ubcf4\ubb3c\uc9c8 \u2018LCAR<\/span>-B38M\u2019\uc758 \uacf5\ub3d9\uac1c\ubc1c\uc5d0 \ub4e4\uc5b4\uac14\ub2e4. \uc2e0\uc57d \uac1c\ubc1c\uc5d0 \uc131\uacf5\ud558\uba74 \uc911\uad6d \ucd5c\ucd08\uc758 \uc720\uc804\uc790 \uce58\ub8cc\uc81c\uac00 \ub41c\ub2e4.\u00a0CAR<\/span>-T\ub294 \uba74\uc5ed\uc138\ud3ec\uc758 \uc77c\uc885\uc778 T\uc138\ud3ec\ub97c \uc720\uc804\uc790 \uc870\uc791\ud574 \uc554\uc138\ud3ec\ub97c \uacf5\uaca9\ud558\ub3c4\ub85d \ud558\ub294 \ucc28\uc138\ub300 \ud56d\uc554\uc81c\ub2e4.<\/p>\n\ub178\ubc14\ud2f0\uc2a4, \uae38\ub9ac\uc5b4\ub4dc \ub4f1 \uae00\ub85c\ubc8c \uc81c\uc57d\uc0ac\ub9cc \ud560 \uc218 \uc788\ub2e4\uace0 \uc5ec\uaca8\uc84c\ub358 \uc720\uc804\uc790 \uce58\ub8cc\uc81c\uc5d0 \ub808\uc804\ub4dc\ubc14\uc774\uc624\ud14d\uc774 \uac00\uc138\ud558\uba74\uc11c \uc911\uad6d\uc758 \ubc14\uc774\uc624 \uae30\uc220 \uacbd\uc7c1\ub825\uc774 \uc120\uc9c4\uad6d \uc218\uc900\uc73c\ub85c \uc62c\ub77c\uc130\ub2e4\ub294 \ud3c9\uac00\ub3c4 \ub098\uc628\ub2e4. \uace8\ub4dc\ub9cc\uc0ad\uc2a4\uc5d0 \ub530\ub974\uba74 \uc911\uad6d\uc740 153\uac74\uc758\u00a0CAR<\/span>-T \uc784\uc0c1\uc744 \uc9c4\ud589\ud574 \ubbf8\uad6d(164\uac74)\uc758 \ub4a4\ub97c \ubc14\uc9dd \ucd94\uaca9\ud558\uace0 \uc788\ub2e4. 3\uc704\uc778 \uc720\ub7fd(73\uac74)\ubcf4\ub2e4 2\ubc30 \uc774\uc0c1 \ub9ce\ub2e4.<\/p>\n <\/p>\n
![](\"https:\/\/imgnews.pstatic.net\/image\/015\/2018\/08\/08\/0003992752_002_20180809011209821.jpg?type=w647\")
<\/span><\/p>\n <\/p>\n
\uc720\uc804\uc790 \uac00\uc704, \uc904\uae30\uc138\ud3ec \ub4f1 \ubc14\uc774\uc624 \uc2e0\uae30\uc220 \ubd84\uc57c\uc5d0\uc11c\ub3c4 \uc911\uad6d\uc774 \uc55e\uc11c\uac00\uace0 \uc788\ub2e4. \uc815\ubd80\uc758 \uc801\uadf9\uc801\uc778 \uc9c0\uc6d0\uacfc \ud22c\uc790\uc5d0 \ud798\uc785\uc740 \uacb0\uacfc\ub2e4. \ud06c\ub9ac\uc2a4\ud37c \uc720\uc804\uc790 \uac00\uc704 \uae30\uc220\uc744 \uae30\ubc18\uc73c\ub85c \ud55c \uc784\uc0c1\uc2dc\ud5d8\uc740 \uc138\uacc4 17\uac74 \uc911 11\uac74\uc744 \uc911\uad6d \uc5f0\uad6c\ud300\uc774 \uc218\ud589\ud558\uace0 \uc788\ub2e4. \ub098\uba38\uc9c0 5\uac74\uc740 \ubbf8\uad6d, 1\uac74\uc740 \ud64d\ucf69\uc5d0\uc11c \uc9c4\ud589 \uc911\uc774\ub2e4. \ud22c\uc790\ub3c4 \ud655\ub300\ub418\ub294 \ucd94\uc138\ub2e4. \uc911\uad6d \uad6d\ub9bd\uc790\uc5f0\uacfc\ud559\uc7ac\ub2e8\uc740 \uc9c0\ub09c 4\ub144\uac04 270\uac74\uc758 \ud06c\ub9ac\uc2a4\ud37c \uc720\uc804\uc790 \uac00\uc704 \ud504\ub85c\uc81d\ud2b8\uc5d0 \uc5f0\uad6c\ube44\ub97c \uc9c0\uc6d0\ud588\ub2e4. \uc9c0\ub09c\ud574 \ud6c4\uc6d0\ud55c \ud504\ub85c\uc81d\ud2b8\ub9cc 90\uac74 \uc774\uc0c1\uc774\ub2e4. \ud55c\uad6d\uc5d0\uc11c\ub294 \uc0dd\uba85\uc724\ub9ac\ubc95 \uaddc\uc81c\uc5d0 \ub9c9\ud600 \uc9c4\ud589\ub418\ub294 \uc784\uc0c1\uc774 1\uac74\ub3c4 \uc5c6\ub2e4.<\/p>\n
\uc904\uae30\uc138\ud3ec \ubd84\uc57c\ub3c4 \uc911\uad6d\uc5d0 \uc5ed\uc804\ub2f9\ud560 \ucc98\uc9c0\ub2e4. \uc2dd\ud488\uc758\uc57d\ud488\uc548\uc804\ud3c9\uac00\uc6d0\uc5d0 \ub530\ub974\uba74 \uc904\uae30\uc138\ud3ec \uc2e0\uaddc \uc784\uc0c1 \uac74\uc218\ub294 2014\ub144\ubd80\ud130 \uc911\uad6d\uc774 \ud55c\uad6d\uc744 \ub118\uc5b4\uc130\ub2e4. 2016\ub144 \uae30\uc900\uc73c\ub85c \uc904\uae30\uc138\ud3ec \uc2e0\uaddc \uc784\uc0c1 47\uac74 \uc911 \uc911\uad6d\uc740 8\uac74\uc73c\ub85c \ubbf8\uad6d(23\uac74) \ub2e4\uc74c\uc73c\ub85c \ub9ce\uc558\ub2e4. 1999\ub144\ubd80\ud130 2016\ub144\uae4c\uc9c0 \ub4f1\ub85d\ub41c \ub204\uc801 \uc784\uc0c1 \uac74\uc218\ub294 \ud55c\uad6d\uc774 46\uac74\uc73c\ub85c \ubbf8\uad6d(155\uac74)\uc5d0 \uc774\uc5b4 \ub450 \ubc88\uc9f8\uc9c0\ub9cc \uc774\ub300\ub85c \uac00\ub2e4\uac04 \uc911\uad6d(29\uac74)\uc5d0 \ucd94\uc6d4\ub2f9\ud560 \uac83\uc774\ub780 \uc6b0\ub824\uac00 \ub098\uc628\ub2e4.<\/p>\n
\uc911\uad6d\uc740 \uc758\uc57d\ud488 \uc704\ud0c1\uc0dd\uc0b0(CMO<\/span>) \uc2dc\uc124\ub3c4 \uacf5\uaca9\uc801\uc73c\ub85c \ud655\ub300\ud558\uace0 \uc788\ub2e4. \uc81c\uc57d\ubc14\uc774\uc624\uc0b0\uc5c5\uc5d0\uc11c\ub3c4 \u2018\uc138\uacc4\uc758 \uacf5\uc7a5\u2019\uc73c\ub85c \ub3c4\uc57d\ud558\ub294 \uac8c \ubaa9\ud45c\ub2e4. \uc911\uad6d \ucd5c\ub300\u00a0CMO<\/span>\u00a0\uc5c5\uccb4 \uc6b0\uc2dc\ubc14\uc774\uc624\ub85c\uc9c1\uc2a4\ub294 4\ub9ccL\uc778 \uc0dd\uc0b0\uaddc\ubaa8\ub97c 2022\ub144\uae4c\uc9c0 22\ub9ccL\ub85c \ub298\ub9b0\ub2e4\ub294 \uacc4\ud68d\uc774\ub2e4. \uc911\uad6d \uc0b0\ub465\uc758 \uc2dc\ub178\ubc14\uc774\uc624\uc6e8\uc774 \ubc14\uc774\uc624\uba54\ub514\uc2a8\uc740 2023\ub144\uae4c\uc9c0 50\ub9ccL\uc758 \uc0dd\uc0b0 \uaddc\ubaa8\ub97c \ud655\ubcf4\ud560 \uc608\uc815\uc774\ub2e4. 36\ub9ccL\uc778 \uc138\uacc4 1\uc704 \uc0bc\uc131\ubc14\uc774\uc624\ub85c\uc9c1\uc2a4\ub97c \ub6f0\uc5b4\ub118\ub294 \uaddc\ubaa8\ub2e4.<\/p>\n\ubc14\uc774\uc624\uc5c5\uacc4 \uad00\uacc4\uc790\ub294 \u201c\uc6b0\uc2dc\ubc14\uc774\uc624\ub85c\uc9c1\uc2a4\uac00 \uc911\uad6d\u00a0CMO<\/span>\u00a0\uc911 \ucd5c\ucd08\ub85c\u00a0FDA<\/span>\u00a0\ud5c8\uac00\ub97c \ubc1b\uc73c\uba74\uc11c \uc911\uad6d\uc758 \ubc14\uc774\uc624\uc758\uc57d\ud488 \uc0dd\uc0b0 \uacbd\uc7c1\ub825\uc5d0 \ub300\ud55c \uc778\uc2dd\uc774 \ubc14\ub00c\uace0 \uc788\ub2e4\u201d\uba70 \u201c\uc911\uad6d \uae30\uc5c5\ub4e4\uc774\u00a0FDA<\/span>\ud5c8\uac00\uc640 \uc0dd\uc0b0 \uacbd\ud5d8\uc744 \ucd95\uc801\ud574 \uae30\uc220\ub825\uae4c\uc9c0 \uac16\ucd94\uac8c \ub41c\ub2e4\uba74 \ud070 \uc704\ud611\uc774 \ub420 \uac83\u201d\uc774\ub77c\uace0 \ub9d0\ud588\ub2e4.<\/p>\n <\/p>\n
<\/p>\n
<\/p>\n
<\/p>\n","protected":false},"excerpt":{"rendered":"
(\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) \ubc14\uc774\uc624 \uc2e0\uae30\uc220 \uc5f0\uad6c \ud65c\ubc1c CAR-T \uc784\uc0c1 \u7f8e \uc774\uc5b4 2\uc704 \ud06c\ub9ac\uc2a4\ud37c \uc720\uc804\uc790\uac00\uc704\ub294 \ub3c5\ubcf4\uc801 \ud55c\uad6d\uc740 \uc0dd\uba85\uc724\ub9ac\ubc95 \ub9c9\ud600 0\uac74 \uc904\uae30\uc138\ud3ec \ubd84\uc57c\ub3c4(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[32,33,34,29],"tags":[6,7,8,3],"class_list":["post-1337","post","type-post","status-publish","format-standard","hentry","category-essays-on-science","category-do-biology","category-lets-do-chemistry","category-lets-do-science","tag-essays-on-science","tag-do-biology","tag-lets-do-chemistry","tag-lets-do-science"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":3605,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3605","url_meta":{"origin":1337,"position":0},"title":"\uc7a5\ub0b4 \ubbf8\uc0dd\ubb3c, \uc554(\u764c) \uce58\ub8cc\uae4c\uc9c0? \ucd5c\ucd08 ‘\uce58\ub8cc\uc81c’ \uc5b8\uc81c \ud0c4\uc0dd\ud560\uae4c & \ubab8\uc18d \ubbf8\uc0dd\ubb3c\ub85c \uac10\uc5fc\uc99d \uce58\ub8cc, \u7f8e\uc11c \u2018\uba39\ub294 \uc57d\u2019 \uccab \uc2b9\uc778","author":"biochemistry","date":"May 31, 2019","format":false,"excerpt":"\u00a0 \u00a0 \ub9c8\uc774\ud06c\ub85c\ubc14\uc774\uc634\uc744 \ud65c\uc6a9\ud55c \uce58\ub8cc\uc81c \uac1c\ubc1c\uc744 \uc704\ud55c \uc784\uc0c1 3\uc0c1\uc774 \ubbf8\uad6d\uc5d0\uc11c \uc9c4\ud589\uc911\uc774\ub2e4. \uad6d\ub0b4 \ubc14\uc774\uc624\uc5c5\uccb4\ub4e4\ub3c4 \uc784\uc0c1 1\uc0c1\uc744 \uc900\ube44\ud558\uace0 \uc788\ub2e4.\/\uc0ac\uc9c4=\ud074\ub9bd\uc544\ud2b8\ucf54\ub9ac\uc544 \u00a0 \u00a0 \uccb4\ub0b4 \ub9c8\uc774\ud06c\ub85c\ubc14\uc774\uc634(\ubbf8\uc0dd\ubb3c \ucd1d)\uc744 \ud65c\uc6a9\ud55c \uc57d \uac1c\ubc1c\uc774 \uc81c\uc57d\u00b7\ubc14\uc774\uc624\uc5c5\uacc4 \uc774\uc288\ub85c \ub5a0\uc624\ub974\uace0 \uc788\ub2e4. \uc11c\uc6b8\ub300 \ud658\uacbd\ubcf4\uac74\ud559\uacfc \uace0\uad11\ud45c \uad50\uc218(\uace0\ubc14\uc774\uc624\ub7a9 \ub300\ud45c)\ub294 \uc9c0\ub09c\ub2ec \uac1c\ucd5c\ub41c \ud55c\uad6d\ubbf8\uc0dd\ubb3c\ud559\ud68c\uc5d0\uc11c \u201c\ub9c8\uc774\ud06c\ub85c\ubc14\uc774\uc634\uc744 \ud65c\uc6a9\ud55c \uc57d\ubb3c \uac1c\ubc1c\uc774 \uc81c\uc57d\uc0ac\ub4e4\uc758 \uc8fc\uc694 \uad00\uc2ec\uc0ac\ub85c \ub5a0\uc62c\ub790\ub2e4\u201d\uba70 \u201c\uad6d\uc81c\uc801\uc778 \uacfc\ud559 \ud559\uc220\uc9c0 \uc140, \ub124\uc774\ucc98\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1540,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1540","url_meta":{"origin":1337,"position":1},"title":"CAR-T, \ud56d\uc554\uc81c\uc2dc\uc7a5 \uac8c\uc784\uccb4\uc778\uc800 \ub418\ub098","author":"biochemistry","date":"September 4, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) \u00a0 \u00a0 \ub178\ubc14\ud2f0\uc2a4 '\ud0b4\ub9ac\uc544'\u00b7\uae38\ub9ac\uc5b4\ub4dc '\uc608\uc2a4\uce74\ub974\ud0c0' \u7f8e \uc774\uc5b4 \uc720\ub7fd\uc11c\ub3c4 \ud310\ub9e4 \ud5c8\uac00 \uac1c\ubc1c\u00b7\uc2dc\ud310 \uacbd\uc7c1 \ub9c9\uc62c\ub77c \u00a0 \u00a0 \u00a0 \u2018\uae30\uc801\uc758 \ud56d\uc554\uc81c\u2019\ub85c \ubd88\ub9ac\ub294 \uba74\uc5ed\uc138\ud3ec\uce58\ub8cc\uc81c \u2018CAR-T(\ud0a4\uba54\ub77c \ud56d\uc6d0 \uc218\uc6a9\uccb4 T\uc138\ud3ec)\u2019\uac00 \ubbf8\uad6d\uc5d0 \uc774\uc5b4 \uc720\ub7fd \uc9c4\ucd9c\uc744 \uacf5\uc2dd\ud654\ud558\uba70 \uad6d\ub0b4\uc678 \uc81c\uc57d \uae30\uc5c5\ub4e4 \uac04\uc758 \uacbd\uc7c1\uc774 \ubcf8\uaca9\ud654\ub420 \uac83\uc73c\ub85c \uc804\ub9dd\ub41c\ub2e4.\u00a0CAR-T\uc758 \uce58\ub8cc \ud6a8\uacfc\uc640 \ubc94\uc704\ub97c \ubcf4\ub2e4 \ub192\uc774\ub824\uace0 \uc560\uc4f0\ub294 \uae30\uc5c5\ub4e4\uc758 \ub178\ub825\uc744\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":634,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=634","url_meta":{"origin":1337,"position":2},"title":"3D \ud504\ub9b0\ud130\ub85c \uc778\uacf5\uac01\ub9c9 \ub9cc\ub4e4\uc5b4\ub0c8\ub2e4","author":"biochemistry","date":"June 1, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \uc601\uad6d \ub274\uce90\uc2ac\ub300\ud559 \uc5f0\uad6c\ud300, \ubc14\uc774\uc624\uc789\ud06c+\uc904\uae30\uc138\ud3ec \uacb0\ud569 \u00a0 3D \ud504\ub9b0\ud305 \uae30\uc220\uc774 \uc758\ud559 \uae30\uc220\uacfc \uc811\ubaa9\ub3fc \uba4b\uc9c4 \uacb0\uacfc\ub97c \ub9cc\ub4e4\uc5b4 \ub0c8\ub2e4. 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