{"id":1230,"date":"2018-07-25T02:01:47","date_gmt":"2018-07-25T02:01:47","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=1230"},"modified":"2023-07-05T15:36:28","modified_gmt":"2023-07-05T06:36:28","slug":"%ec%88%98%ec%88%a0-%ec%97%86%ec%9d%b4-%eb%87%8c-%ed%9a%8c%eb%a1%9c%eb%a5%bc-%ec%bc%9c%ea%b3%a0-%eb%81%84%eb%8a%94-%ea%b8%b0%ec%88%a0-%ea%b0%9c%eb%b0%9c","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1230","title":{"rendered":"\uc218\uc220 \uc5c6\uc774 \ub1cc \ud68c\ub85c\ub97c \ucf1c\uace0 \ub044\ub294 \uae30\uc220 \uac1c\ubc1c"},"content":{"rendered":"

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(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n

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[\uc694\uc57d]\ubbf8\uad6d \uce98\ub9ac\ud3ec\ub2c8\uc544\uacf5\uacfc\ub300\ud559 \uc5f0\uad6c\uc9c4\uc774 \ube44\uce68\uc2b5\uc801\uc778 \ubc29\uc2dd\uc73c\ub85c \ub1cc\uc758 \uc2e0\uacbd\uc138\ud3ec \ud65c\uc131\ud654\ub97c \uc870\uc808\ud560 \uc218 \uc788\ub294 \uae30\uc220\uc744 \uac1c\ubc1c\ud588\ub2e4. \uc774 \ubc29\uc2dd\uc744 \uc950\uc5d0 \uc801\uc6a9\ud574 \uae30\uc5b5\ub825\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ub1cc \ud574\ub9c8 \uc2e0\uacbd\uc138\ud3ec\uc758 \ud65c\uc131\ud654\ub97c \uc7a0\uc2dc \uaebc\ud2b8\ub9ac\uc790 \uc950\ub294 \uc77c\uc2dc\uc801\uc73c\ub85c \uae30\uc5b5\uc744 \ud615\uc131\ud558\uc9c0 \ubabb\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\ub2e4. \uc5f0\uad6c\uc9c4\uc740 \ud5a5\ud6c4 \ub1cc\uc804\uc99d\uc774\ub098 \ud30c\ud0a8\uc2a8\ubcd1 \ub4f1 \uc2e0\uacbd\uc815\uc2e0 \uc9c8\ud658 \uce58\ub8cc\uc2dc \ub450\uac1c\uace8 \uc808\uac1c \uc5c6\uc774\ub3c4 \ub1cc\ub97c \uc790\uadf9\ud574 \uce58\ub8cc\ud560 \uc218 \uc788\uc744 \uac83\uc73c\ub85c \uae30\ub300\ud558\uace0 \uc788\ub2e4.\u00a0(2018.07)<\/h6>\n

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\n\ubbf8\ud558\uc77c \uc0e4\ud53c\ub85c \ubbf8\uad6d \uce98\ub9ac\ud3ec\ub2c8\uc544\uacf5\uacfc\ub300\ud559(\uce7c\ud14d) \ud654\ud559\uacf5\ud559\uacfc \uad50\uc218 \uc5f0\uad6c\uc9c4\uc740 \ubbf8\ub798 \uacfc\ud559\uc790\uc640 \uc758\uc0ac\ub4e4\uc774 \uc678\uacfc \uc218\uc220 \uc5c6\uc774 \uc5b4\ub5bb\uac8c \uc2e0\uacbd\ud68c\ub85c\ub97c \uc120\ud0dd\uc801\uc73c\ub85c \ucf1c\uace0 \ub04c \uc218 \uc788\ub294\uc9c0 \ubcf4\uc5ec\uc8fc\uace0 \uc788\ub2e4. 7\uc6d4 9\uc77c \uad6d\uc81c\ud559\uc220\uc9c0 ‘\ub124\uc774\ucc98 \ubc14\uc774\uc624\uba54\ub514\uce7c \uc5d4\uc9c0\ub2c8\uc5b4\ub9c1’\uc5d0 \uac8c\uc7ac\ub41c \uc774\ubc88 \uc5f0\uad6c\ub294 \ucd08\uc74c\ud30c \uce58\ub8cc, \uc720\uc804\uc790 \uce58\ub8cc, \ud569\uc131 \uc57d\ubb3c \ub4f1 \uc138\uac00\uc9c0 \uce58\ub8cc\ub97c \uc774\uc6a9\ud574 \uc950\uc758 \uae30\uc5b5 \ud615\uc131 \uacfc\uc815\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\uc74c\uc744 \uc785\uc99d\ud588\ub2e4. \uc0ac\ud53c\ub85c \uad50\uc218\ub294 “\uc74c\ud30c\uc640 \uc720\uc804 \uae30\uc220\uc744 \uc0ac\uc6a9\ud568\uc73c\ub85c\uc368 \uc6b0\ub9ac\ub294 \ucc98\uc74c\uc73c\ub85c \ube44\uce68\uc2b5\uc801\uc778 \ubc29\uc2dd\uc73c\ub85c \ud2b9\uc815 \ub1cc \uc601\uc5ed\uc740 \ubb3c\ub860 \uc6d0\ud558\ub294 \uc138\ud3ec\ub97c \ud1b5\uc81c\ud560 \uc218 \uc788\uac8c \ub410\ub2e4”\uba70 “\ub610\ud55c \ub274\ub7f0 \uc2a4\uc704\uce58\uac00 \ucf1c\uc9c0\uac70\ub098 \uaebc\uc9c0\ub294 \ud0c0\uc774\ubc0d\ub3c4 \ub9de\ucd9c \uc218 \uc788\ub2e4”\uace0 \ub9d0\ud588\ub2e4. \uc774\ubc88 \uc5f0\uad6c\ub294 \ub3d9\ubb3c\uc5d0 \ub300\ud55c \uae30\ucd08\uc5f0\uad6c\ub97c \ube44\ub86f\ud574 \ubbf8\ub798 \uc2e0\uacbd\u00b7\uc815\uc2e0 \uc9c8\ud658 \uce58\ub8cc\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\ub2e4. \uc2e0\uacbd \ud68c\ub85c\ub97c \ubbf8\uc138\ud558\uac8c \uc870\uc815\ud558\ub824\ub294 \uc2dc\ub3c4\ub294 \ucc98\uc74c\uc774 \uc544\ub2c8\ub2e4. \uc608\ub97c \ub4e4\uc5b4 \uad11\uc720\uc804\ud559\uc774\ub77c \ubd88\ub9ac\ub294 \uae30\uc220\uc740 \uad11\uc12c\uc720\ub97c \ub1cc\uc5d0 \uc0bd\uc785\ud574 \ube5b\uc744 \uc774\uc6a9\ud574 \ub1cc\ub97c \uc790\uadf9\ud560 \uc218 \uc788\ub2e4. \uc0ac\ud53c\ub85c \uad50\uc218\uac00 \uc2dc\ub3c4\ud558\ub294 \uc0c8\ub85c\uc6b4 \ubc29\uc2dd\uc740 \uc74c\ud30c\ub97c \uc774\uc6a9\ud558\ub294 \uac83\uc774\ub2e4. \uc0ac\ud53c\ub85c \uad50\uc218 \uc5f0\uad6c\uc9c4\uc740 \uc774\uc804 \uc5f0\uad6c\ub97c \ud1b5\ud574 \uc74c\ud30c\ub97c \uc774\uc6a9\ud574 \uccb4\ub0b4\uc5d0 \uc788\ub294 \uc138\ud3ec\uc758 \uae30\ub2a5\uc744 \ud1b5\uc81c\ud558\ub294\ub370 \uc131\uacf5\ud55c \ubc14 \uc788\ub2e4. \uc0c8\ub85c\uc6b4 \uc5f0\uad6c\uc5d0\uc11c \uc74c\ud30c\ub294 \ud608\uc561 \uc18d\uc5d0 \ub123\uc740 \uc791\uc740 \uae30\ud3ec\uc640 \uacb0\ud569\ud574 \uc77c\uc2dc\uc801\uc73c\ub85c ‘\ud608\uc561 \ub1cc \uc7a5\ubcbd(blood-brain barrier)’\uc744 \uc5f0\ub2e4. \ud608\uc561 \ub1cc \uc7a5\ubcbd\uc740 \ud608\uc561 \uc18d \uc774\ubb3c\uc9c8\uc774 \ub1cc\ub85c \ub4e4\uc5b4\uac00\ub294 \uac83\uc744 \ub9c9\ub294 \uc5ed\ud560\uc744 \ud55c\ub2e4. \uc774\ubc88 \uc5f0\uad6c\uc758 1\uc800\uc790\ub85c \uc0ac\ud53c\ub85c \uad50\uc218 \uc5f0\uad6c\uc2e4\uc5d0\uc11c \ubc15\uc0ac\ud6c4\uc5f0\uad6c\uc6d0\uc744 \ud558\uace0 \uc788\ub294 \uc608\uc9c0 \uc2a4\uc790\ube14\ub85c\uc2a4\ud0a4 \uce7c\ud14d \ubc15\uc0ac\ub294 “\uae30\ud3ec\uac00 \ucd08\uc74c\ud30c\uc640 \ubd80\ub52a\uce58\uba74 \uc9c4\ub3d9\ud558\uace0 \ud608\uc561 \ub1cc \uc7a5\ubcbd\uc744 \uc9e7\uc740 \uae30\uac04 \ub3d9\uc548 \uc5f0\ub2e4”\uace0 \uc124\uba85\ud588\ub2e4.<\/p>\n

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\uce7c\ud14d \uc5f0\uad6c\uc9c4\uc774 \uac1c\ubc1c\ud55c ATAC \uae30\uc220 \ubaa8\uc2dd\ub3c4. \ucd08\uc74c\ud30c\ub97c \uc774\uc6a9\ud574 \ub1cc \ud608\uc561 \uc7a5\ubcbd\uc758 \ubb38\uc744 \uc5f4\uace0 \uadf8 \uc548\uc5d0 \uc57d\ubb3c\uc744 \ub123\uc5b4 \ud2b9\uc815 \ubd80\uc704\uc758 \uc2e0\uacbd\uc138\ud3ec\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce60 \uc218 \uc788\ub2e4. <\uc0ac\uc9c4\uc81c\uacf5=\uce7c\ud14d><\/span><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n
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\ud608\uc561 \ub1cc \uc7a5\ubcbd\uc758 \uc77c\uc2dc\uc801\uc778 \uac1c\ubc29\uc740 \uc2e0\uacbd \ud68c\ub85c\ub97c \uc870\uc808\ud558\uae30 \uc704\ud55c \uc138\uac00\uc9c0 \uc804\ub7b5 \uc911 \uccab \ubc88\uc9f8 \ub2e8\uacc4\uc5d0 \uaf3d\ud78c\ub2e4. \ucd08\uc74c\ud30c\ub97c \uc774\uc6a9\ud574 \ubaa9\ud45c\ud588\ub358 \uc9c0\uc5ed\uc758 \ud608\uc561 \ub1cc \uc7a5\ubcbd\uc774 \uc5f4\ub9ac\uba74 \uc5f0\uad6c\uc9c4\uc740 \uc720\uc804\uc790 \uce58\ub8cc\ub97c \uc0ac\uc6a9\ud55c\ub2e4. \ubc14\uc774\ub7ec\uc2a4\uac00 \ud608\uc561\uc73c\ub85c \uc804\ub2ec\ub418\uace0 \uc774\uac83\uc740 \ud608\uc561 \ub1cc \uc7a5\ubcbd\uc744 \uc9c0\ub098 \uc5f0\uad6c\uc9c4\uc774 \uc6d0\ud558\ub294 \uc138\ud3ec\ub85c \ubc30\ub2ec\ub41c \ub4a4 \uc720\uc804\uc801\uc778 ‘\uc9c0\uc2dc’\ub97c \ub0b4\ub9b0\ub2e4. \uc774\uac19\uc740 \uc720\uc804\uc801 \uc9c0\uc2dc\ub294 ‘\ucf00\ubaa8 \uc81c\ub124\ud2f1’ \uc218\uc6a9\uccb4\ub77c \ubd80\ub974\ub294\ub370 \uc2e4\ud5d8\uc2e4\uc5d0\uc11c \ub9cc\ub4e0 \ud2b9\uc815\ud55c \uc57d\ubb3c\uc5d0 \ubc18\uc751\ud558\ub3c4\ub85d \uc124\uacc4\ub410\ub2e4. \ub9c8\uc9c0\ub9c9 \ub2e8\uacc4\ub294 \uc57d\ubb3c\uc744 \ud22c\uc5ec\ud558\uace0 \ud2b9\uc815 \ub274\ub7f0\uc744 \ud06c\uace0 \uaef4\ub294 \uac83\uc774\ub2e4. \uc0c8\ub85c\uc6b4 \uc5f0\uad6c\uc5d0\uc11c \uc5f0\uad6c\uc9c4\uc740 \uc774 \uae30\uc220\uc744 \uc950\uc758 \uae30\uc5b5 \ud615\uc131\uc5d0 \uad00\uc5ec\ud558\ub294 \ub1cc\uc758 ‘\ud574\ub9c8’\uc5d0 \uc801\uc6a9\ud588\ub2e4. \uc950\uc5d0\uac8c \ucf00\ubaa8 \uc81c\ub124\ud2f1 \uc57d\uc744 \uc8fc\uc5c8\uc744 \ub54c \uc774 \ub274\ub7f0\uc740 \uaebc\uc84c\uace0, \uadf8 \uacb0\uacfc\ub85c \uc950\ub294 \uc77c\uc2dc\uc801\uc73c\ub85c \uc0c8\ub85c\uc6b4 \uae30\uc5b5\uc744 \ud615\uc131\ud558\uc9c0 \ubabb\ud588\ub2e4.
\n\uc0ac\ud53c\ub85c \uad50\uc218 \uc5f0\uad6c\uc9c4\uc758 \uae30\uc220\uc740 \ucf00\ubaa8\uc81c\ub124\ud2f1\uacfc \ucd08\uc74c\ud30c\ub97c \ud569\ud55c \ub9cc\ud07c \uc5f0\uad6c\uc9c4\uc740 \uc774 \uae30\uc220\uc5d0 ‘\uc74c\ud5a5 \ud45c\uc801 \ucf00\ubaa8 \uc81c\ub124\ud2f1\uc2a4(ATC\u00b7Acoustically Targeted Chemogenetics)’ \ub610\ub294 ATAC\ub77c\ub294 \ubcc4\uba85\uc744 \uc9c0\uc5b4\uc92c\ub2e4. \uc774\ubc88 \uc5f0\uad6c\uc5d0 \ucc38\uc5ec\ud558\uc9c0 \uc54a\uc740 \ube0c\ub77c\uc774\uc5b8 \ub85c\uc2a4 \ub178\uc2a4\uce90\ub864\ub77c\uc774\ub098\ub300 \uc57d\ub9ac\ud559\uacfc \uad50\uc218\ub294 “\ub9e4\uc6b0 \uc778\uc0c1\uc801\uc778 \uc5f0\uad6c\uacb0\uacfc”\ub77c\uba70 “\ud601\uc2e0\uc801\uc778 \uc811\uadfc \ubc29\uc2dd\uc740 \ub9ce\uc740 \uc2e0\uacbd\uacfc\ud559\uc790\ub4e4\uc774 \uc720\uc6a9\ud558\uac8c \uc0ac\uc6a9\ud560 \uc218 \uc788\uc744 \uac83”\uc774\ub77c\uace0 \ub9d0\ud588\ub2e4. \uc0ac\ud53c\ub85c \uad50\uc218\ub294 “\uc6b0\ub9ac \ubc29\uc2dd\uc740 \ub3d9\ubb3c\uc2e4\ud5d8\uc744 \uac70\uccd0 \uc870\uae08\uc529 \uc784\uc0c1\uc73c\ub85c \uac00\uace0 \uc788\ub294 \uae30\uc220\ub4e4\uc758 \uc870\ud569”\uc774\ub77c\uba70 “\uc774 \ub54c\ubb38\uc5d0 \uc6b0\ub9ac\uac00 \ucc98\uc74c \uc2dc\uc791\ud588\uc744 \ub54c\ubcf4\ub2e4 \uc9c0\uae08 \ub354 \ube60\ub978 \ubc1c\uc804 \uc18d\ub3c4\ub97c \ubcf4\uc774\uace0 \uc788\ub2e4”\uace0 \ub9d0\ud588\ub2e4.
\n\uc5f0\uad6c\uc9c4\uc740 \ucd94\ud6c4 \ub1cc\uc804\uc99d\uc744 \uc553\uace0 \uc788\ub294 \ub3d9\ubb3c\uc744 \ub300\uc0c1\uc73c\ub85c \uc2e4\ud5d8\uc744 \ud558\uace0 \uc2f6\ub2e4\uace0 \ubc1d\ud614\ub2e4. \ud604\uc7ac \ub1cc\uc804\uc99d\uc744 \uc553\uace0 \uc788\ub294 \ub9ce\uc740 \ud658\uc790\ub4e4\uc740 \ubc1c\uc791\uc774 \uc77c\uc5b4\ub098\ub294 \uac83\uc73c\ub85c \uc608\uc0c1\ub418\ub294 \ubd80\uc704\ub97c \uc798\ub77c\ub0b4\ub294 \uc218\uc220\uc744 \ubc1b\uace0 \uc788\ub2e4. ATAC \uae30\uc220\uc744 \uc774\uc6a9\ud558\uba74 \uc218\uc220 \uc5c6\uc774 \uc6d0\ud558\ub294 \ub1cc \ubd80\uc704\uc758 \ud65c\uc131\uc744 \uc81c\uc5b4\ud560 \uc218 \uc788\ub2e4. \uc2a4\uc790\ube14\ub85c\uc2a4\ud0a4 \ubc15\uc0ac\ub294 “\uc774 \ubc29\uc2dd\uc740 \uac00\uc5ed\uc801”\uc774\ub77c\uba70 “\ud2b9\uc815 \ub274\ub7f0\uc744 \ub044\uae30 \uc704\ud55c \uc57d\ubb3c\uc744 \ub123\uc744 \uc218 \uc788\uc9c0\ub9cc \uc2dc\uac04\uc774 \uc9c0\ub098\uace0 \ub098\uba74 \uc774 \uc138\ud3ec\ub4e4\uc740 \ub2e4\uc2dc \ud65c\uc131\ud654\ub41c\ub2e4”\uc774\ub77c\uace0 \ub9d0\ud588\ub2e4. \uadf8\ub294 “\uc57d\ubb3c \ud22c\uc5ec\ub97c \ud1b5\ud574 \ud2b9\uc815 \ub1cc \ubd80\uc704\ub97c \uc5bc\ub9c8\ub098 \uc81c\uc5b4\ud574\uc57c \ud558\ub294\uc9c0\ub3c4 \ud655\uc778\ud560 \uc218 \uc788\uc744 \uac83”\uc774\ub77c\uace0 \ub367\ubd99\uc600\ub2e4.<\/p>\n

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\uc6d0\ubb38\ucd9c\ucc98 :\u00a0http:\/\/www.caltech.edu\/news\/<\/u>switching-brain-circuits-and-without-surgery-82767<\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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