{"id":1128,"date":"2018-07-17T04:11:29","date_gmt":"2018-07-17T04:11:29","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=1128"},"modified":"2023-07-05T15:38:53","modified_gmt":"2023-07-05T06:38:53","slug":"gene-editing-gets-a-head-start","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1128","title":{"rendered":"Gene editing gets a head start"},"content":{"rendered":"

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Science\u00a0<\/cite>\u00a013 Jul 2018:
\nVol. 361, Issue 6398, pp. 142
\nDOI: 10.1126\/science.361.6398.142-b<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n

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The development of gene-editing technologies into therapies for human disease is an exciting prospect. A crucial question is whether there are advantages to correcting disease-causing mutations before rather than after birth, and whether this approach is even feasible. In a proof-of-concept study in mice, Ricciardi\u00a0et al.<\/em>\u00a0accomplished successful in utero correction of a hemoglobin gene mutation that causes \u03b2-thalassemia, a serious blood disorder. They injected nanoparticles containing gene-editing machinery (triplex-forming peptide nucleic acids and single-stranded donor DNA) intravenously into midgestational mouse fetuses. After birth, the treated mice showed sustained amelioration of anemia and survived longer than untreated mice.<\/p>\n

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Nat. Commun.<\/em>\u00a010.1038\/s41467-018-04894-2 (2018).<\/p>\n

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    (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~)     Science\u00a0\u00a013 Jul 2018: Vol. 361, Issue 6398, pp. 142 DOI: 10.1126\/science.361.6398.142-b     The development of gene-editing technologies(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2},"jetpack_post_was_ever_published":false},"categories":[33,29,30],"tags":[7,3,4],"class_list":["post-1128","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","category-recent-science-news","tag-do-biology","tag-lets-do-science","tag-recent-science-news"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t