Science\u00a0<\/cite>\u00a013 Jul 2018:
\nVol. 361, Issue 6398, pp. 142
\nDOI: 10.1126\/science.361.6398.142-b<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n <\/p>\n
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The development of gene-editing technologies into therapies for human disease is an exciting prospect. A crucial question is whether there are advantages to correcting disease-causing mutations before rather than after birth, and whether this approach is even feasible. In a proof-of-concept study in mice, Ricciardi\u00a0et al.<\/em>\u00a0accomplished successful in utero correction of a hemoglobin gene mutation that causes \u03b2-thalassemia, a serious blood disorder. They injected nanoparticles containing gene-editing machinery (triplex-forming peptide nucleic acids and single-stranded donor DNA) intravenously into midgestational mouse fetuses. After birth, the treated mice showed sustained amelioration of anemia and survived longer than untreated mice.<\/p>\n <\/p>\n
Nat. Commun.<\/em>\u00a010.1038\/s41467-018-04894-2 (2018).<\/p>\n <\/p>\n
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<\/p>\n","protected":false},"excerpt":{"rendered":"
(\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) Science\u00a0\u00a013 Jul 2018: Vol. 361, Issue 6398, pp. 142 DOI: 10.1126\/science.361.6398.142-b The development of gene-editing technologies(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[33,29,30],"tags":[7,3,4],"class_list":["post-1128","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-science","category-recent-science-news","tag-do-biology","tag-lets-do-science","tag-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":976,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=976","url_meta":{"origin":1128,"position":0},"title":"CRISPR with a heart of gold helps ailing mice","author":"biochemistry","date":"June 28, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 \u00a0 Gene-editing molecules ride gold nanoparticles into the brain. \u00a0 Expression of a protein (blue-green, left) associated with fragile X syndrome is suppressed (right) in the brains of mice treated with CRISPR gene-editing molecules. 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Eng. \u00a0 \u00a0 Scientists are mining gold\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":1535,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1535","url_meta":{"origin":1128,"position":1},"title":"Canine CRISPR trial raises \ufeffhopes for humans with deadly disease","author":"biochemistry","date":"September 2, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 Dogs with a disorder similar to Duchenne muscular dystrophy improve after gene-editing treatment. \u00a0 \u00a0 A powerful gene-editing technique can stimulate dogs\u2019 production of an important muscle protein, a finding that takes researchers a step closer to trying the technology in humans who have a\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":3984,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=3984","url_meta":{"origin":1128,"position":2},"title":"Enriching stem cells for gene editing","author":"biochemistry","date":"August 3, 2019","format":false,"excerpt":"\u00a0 \u00a0 Gene editing using CRISPR-Cas9 may allow targeted treatment for a variety of genetic diseases. 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