{"id":1126,"date":"2018-07-17T04:09:39","date_gmt":"2018-07-17T04:09:39","guid":{"rendered":"http:\/\/163.180.4.222\/lab\/?p=1126"},"modified":"2023-07-05T14:47:06","modified_gmt":"2023-07-05T05:47:06","slug":"engineering-multilayered-cellular-structures","status":"publish","type":"post","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=1126","title":{"rendered":"Engineering multilayered cellular structures"},"content":{"rendered":"

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(\uc6d0\ubb38: \uc5ec\uae30<\/a>\ub97c \ud074\ub9ad\ud558\uc138\uc694~)<\/p>\n

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Science\u00a0<\/cite>\u00a013 Jul 2018:
\nVol. 361, Issue 6398, pp. 141-143
\nDOI: 10.1126\/science.361.6398.141-k<\/p>\n

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The ability to program the manufacture of biological structures may yield new biomaterials or synthetic tissues and organs. Toda\u00a0et al.<\/em>\u00a0engineered mammalian \u201csender\u201d and \u201creceiver\u201d cells with synthetic cell surface ligands and receptors that controlled gene regulatory circuits based on Notch signaling. Programming the cells to express cell adhesion molecules and other regulatory molecules enabled spontaneous formation of multilayered structures, like those that form during embryonic development. The three-layered structures even showed regeneration after injury.<\/p>\n

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Science<\/em>, this issue p.\u00a0156<\/a><\/p>\n

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    (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~)     Science\u00a0\u00a013 Jul 2018: Vol. 361, Issue 6398, pp. 141-143 DOI: 10.1126\/science.361.6398.141-k       The ability to program(more…)<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[33,34,29,30],"tags":[7,8,3,4],"class_list":["post-1126","post","type-post","status-publish","format-standard","hentry","category-do-biology","category-lets-do-chemistry","category-lets-do-science","category-recent-science-news","tag-do-biology","tag-lets-do-chemistry","tag-lets-do-science","tag-recent-science-news"],"aioseo_notices":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack-related-posts":[{"id":4114,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=4114","url_meta":{"origin":1126,"position":0},"title":"Glowing DNA label illuminates a cell\u2019s fine details","author":"biochemistry","date":"September 23, 2019","format":false,"excerpt":"\u00a0 \u00a0 Fluorescent tag can be affixed to proteins or genetic structures of interest. \u00a0 \u00a0 DNA tags could help scientists to study ion channels (yellow), which allow specific ions to pass through the membrane of nerve cells (green). 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Their system\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2582,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2582","url_meta":{"origin":1126,"position":2},"title":"Technologies to watch in 2019","author":"biochemistry","date":"January 29, 2019","format":false,"excerpt":"\u00a0 \u00a0 From higher-resolution imaging to genome-sized DNA molecules built from scratch, the year ahead looks exciting for life-science technology. \u00a0 An automated bioreactor system for growing yeast, which can be used to investigate synthetic genomes \u2014 one area poised to make big strides this year.Credit: Tim Llewellyn\/Ginkgo Bioworks \u00a0\u2026","rel":"","context":"In "Essays on Science"","block_context":{"text":"Essays on Science","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=32"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":976,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=976","url_meta":{"origin":1126,"position":3},"title":"CRISPR with a heart of gold helps ailing mice","author":"biochemistry","date":"June 28, 2018","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38) \u00a0 \u00a0 \u00a0 Gene-editing molecules ride gold nanoparticles into the brain. \u00a0 Expression of a protein (blue-green, left) associated with fragile X syndrome is suppressed (right) in the brains of mice treated with CRISPR gene-editing molecules. Credit: B. Lee\u00a0et al.\/Nature\u00a0Biomed. Eng. \u00a0 \u00a0 Scientists are mining gold\u2026","rel":"","context":"In "Let's Do Biology!"","block_context":{"text":"Let's Do Biology!","link":"https:\/\/biochemistry.khu.ac.kr\/lab\/?cat=33"},"img":{"alt_text":"","src":"","width":0,"height":0},"classes":[]},{"id":2793,"url":"https:\/\/biochemistry.khu.ac.kr\/lab\/?p=2793","url_meta":{"origin":1126,"position":4},"title":"Converting light into ATP","author":"biochemistry","date":"March 7, 2019","format":false,"excerpt":"\u00a0 \u00a0 (\uc6d0\ubb38: \uc5ec\uae30\ub97c \ud074\ub9ad\ud558\uc138\uc694~) Angew. Chem. (2019). \u00a0 \u00a0 Artificial cells are compartmentalized structures that can mimic essential functions of their biological counterpart. They have been useful to understand and recreate minimalistic metabolic pathways and the structure of protocells. 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