Peer-Reviewed Publications [* denotes corresponding author(s)]

(The author, whose name is written in blue, is a current or previous member of The Hah Group.)

Kang, S.; Hah, S. S.* (Jul 2014). "Improved ligand binding by antibody-aptamer pincers" Bioconjug. Chem., 25, 1421-1427.

Lee, G.-H.; Yu, B.-Y.; Kim, J.*; Song, J. H.*; Hah, S. S.* (Jul 2014). "Accelerator mass spectrometry-based signal generation for thin layer chromatography" Bull. Korean Chem. Soc., 35, 3363-3365.

Suh, S.-K.; Song, S. (co-first author); Oh, H.-B.; Hwang, S.-H.*; Hah, S. S.* (Jun 2014). "Aptamer-based competitive binding assay for one-step quantitation of hepatitis B surface antigen" Analyst, 139, 4310-4314.

Song, S.; Cho, Y. S.; Lee, S.-J.; Hah, S. S.* (May 2014). "Aptamer-based precipitation as an alternative to the conventional immunoprecipitation for purification of target proteins" Bull. Korean Chem. Soc., 35, 2665-2668.

Park, J. H.; Cho, Y. S. (co-first author); Kang, S.; Lee, E. J.; Lee, G.-H.; Hah, S. S.* (Jul 2014). "A colorimetric sandwich-type assay for sensitive thrombin detection based on enzyme linked aptamer assay" Anal. Biochem., 462, 10-12.

Lee, E. J.; Cho, Y. S.; Song, S.; Hwang, S.-H.*; Hah, S. S.* (May 2014). "FRET-based quantitative discrimination of bisulfate-untreated DNA from bisulfate-treated DNA" Bull. Korean Chem. Soc., 35, 1455-1459.

Kang, W.; Hong, S. H.; Lee, H. M.; Kim, N. Y.; Lim, Y. C.; Le, L. T. M.; Kim, H. C.; Kim, T. Y.; Ashida, H.; Yokota, A.; Hah, S. S.; Chun, K. H.; Jung, Y.-K.; Yang, J. K.* (Jan 2014). "Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme" Proc. Natl. Acad. Sci. USA, 111, E54-E61.

Hwang, S.-H.; Im, S.-G.; Sung, H.; Hah, S. S.; Cong, V. T.; Lee, D.-H.; Son, S. J.; Oh, H.-B.* (Jan 2014). "Upconversion nanoparticle-based Föster resonance energy trasnfer for detecting the IS6110 sequence of Mycobacterium tuberculosis comlpex in sputum" Biosens. Bioelectron., 53, 112-116.

Lee, G.-H.; Lee, E. J.; Hah, S. S.* (Jan 2014). "TAMRA- and Cy5-labeled probe for efficient kinetic characterization of caspase-3" Anal. Biochem., 446, 22-24.

Jeong, M.; Park, J. M. (co-first author); Lee, E. J. (co-first author); Cho, Y. S.; Lee, C.; Kim, J. M.; Hah, S. S.* (Nov 2013). "Cytotoxicity of ultra-pure TiO2 and ZnO nanoparticles generated by laser ablation" Bull. Korean Chem. Soc., 34, 3301-3306.

Hwang, S.-H.; Im, S.-G.; Hah, S. S.; Cong, V. T.; Lee, E. J.; Lee, Y.-S.; Lee, G. K.; Lee, D.-H.*; Son, S. J.*; (Sep 2013). "Effects of upconversion nanoparticles on polymerase chain reaction" PLoS One, 8, e73408.

Cho, Y. S.; Lee, E. J. (co-first author); Shin, S.; Hah, S. S.* (Jun 2013). "Combination of aptamer-functionalized quantum dots and electrophoretic mobility shift assay for specific detection and quantitation of proteins of interest" Quant. Bio-Sci., 32, 25-29.

Shin, S.; Kim, Y. S. (co-first author); Kim, J.; Kwon, H.-M.; Kim, D.-E.*; Hah, S. S.* (Apr 2013). "Sniffing for gene silencing efficiency of siRNAs in HeLa cells in comparison with that in HEK293T cells: Correlation between knockdown efficiency and sustainability of siRNAs revealed by FRET-based probing" Nucleic Acid Therapeutics, 23, 152-159.

Lee, E. J.; Lim, H. K.; Cho, Y. S.; Hah, S. S.* (Apr 2013). "Peptide nucleic acids are an additional class of aptamers" RSC Adv., 3, 5828-5831.

Nam, H. Y.; Cho, Y. S. (co-first author); Jung, W. (co-first author); Kang, H.-J.; Hah, S. S.* (Mar 2013). "RNA aptamer-functionalized quantum dots for detection of His-tagged proteins in Escherichia coli" Bull. Korean Chem. Soc., 34, 997-999.

Kim, J.; Lee, G.-H. (co-first author); Jung, W.; Hah, S. S.* (Jan 2013). "Selective and quantitative cell detection based both on aptamers and the conventional cell-staining methods" Biosens. Bioelectron., 43, 362-365.

Lim, H. K.; Kim, I.-H. (co-first author); Nam, H. Y.; Shin, S.; Hah, S. S.* (Jan 2013). "Aptamer-based alternatives to the conventional immobilized metal affinity chromatography for purification of His-tagged proteins" Anal. Lett., 46, 407-415.

Lee, G.-H.; Lim, H. K. (co-first author); Jung, W.; Hah, S. S.* (Nov 2012). "Incorporation efficiency of 5’-azido-5’-deoxyguanosine into 5’-terminus of RNA for preparation of azido-functionalized RNA" Bull. Korean Chem. Soc., 33, 3861-3863.

Kim, Y. S.; Kim, K. K. (co-first author); Shin, S.; Park, S. M.*; Hah, S. S.* (Oct 2012). "Comparative toxicity studies of ultra-pure Ag, Au, Co, and Cu nanoparticles generated by laser ablation in biocompatible aqueous solution" Bull. Korean Chem. Soc., 33, 3265-3268.

Shin, S.; Nam, H. Y. (co-first author); Lee, E. J. (co-first author); Jung, W.; Hah, S. S.* (Oct 2012). "Molecular beacon-based quantitation of epithelial tumor marker Mucin1" Bioorg. Med. Chem. Lett., 22, 6081-6084.

Kim, M. Y.; Kim, J.; Hah, S. S.* (Oct 2012). "Poly(A)-targeting molecular beacons: FRET-based in vitro quantitation and time-dependent imaging in live cells" Anal. Biochem., 429, 92-98.

Chung, D.; Kang, H.-J.; Jang, Y. P.*; Jung, W.; Hah, S. S.* (Apr 2012). "Preparation of a thiolated derivative of A2E, a pigment of the lipofuscin of retinal pigment epithelial cells" Bull. Korean Chem. Soc., 33, 1386-1388.

Lee, G.-H.; Hah, S. S.* (Mar 2012). "Ultrasensitive probing studies using accelerator mass spectrometry" ChemWorld, 52, 12-20 (Review in Korean).

Hah, S. S.* (Feb 2012). "Metabolomics for biomarker discovery based on accelerator mass spectrometry" J. Metabolomics, 2, e112 (Editorial).

     # "Most viewed" article (#12 out of all the papers published in J. Metabolomics, as of Sep 2012).

Lee, G.-H.; Hah, S. S.* (Feb 2012). "Coomassie blue is sufficient for specific protein detection of aptamer-conjugated chips" Bioorg. Med. Chem. Lett., 22, 1520-1522.

Kim, S.-Y.; Kim, J. (co-first author); Hwang, S.-H.*; Park, H.-K.; Lee, J.-H.; Lee, D.-H.; Hah, S. S.; Park, D. Y. (Feb 2012). "Pro-gastrin-releasing peptide (ProGRP) is a candidate marker for quality control in clinical sample processing and storage" Am. J. Clin. Pathol., 137, 277-282.  

Kim, Y. S.; Kim, M. Y.; Song, J. K.; Kim, T. J.*; Kim, Y. D.*; Hah, S. S.* (Jan 2012). "Stepwise fluorescence changes of quantum dots: Single molecule spectroscopic studies on the properties of turn-on quantum dots" Chem. Commun., 48, 723-725.

Lee, G.-H.; Lim, H. K.; Hah, S. S.* (Oct 2011). "Preparation of 5’-azido-5’-deoxyguanosine and its efficiency for click chemistry" Bull. Korean Chem. Soc., 32, 3767-3769.

Shin, S.; Kwon, H.-M. (co-first author); Yoon, K.-S.; Kim, D.-E.*; Hah, S. S.* (Jul 2011). "FRET-based probing to gain direct information on siRNA sustainability in live cells: Asymmetric degradation of siRNA strands" Mol. BioSyst., 7, 2110-2113.

     # The 3rd most-accessed Mol. BioSyst. article in May 2011.

Kim, J.; Kim, M. Y.; Kim, H. S.; Hah, S. S.* (Jul 2011). "Binding of uranyl ion by a DNA aptamer attached to a solid support" Bioorg. Med. Chem. Lett., 21, 4020-4022.

Park, K.; Choi, B.-R.; Kim, Y. S.; Shin, S.; Hah, S. S.; Jung, W.; Oh, S.; Kim, D.-E.* (Jul 2011). "Detection of single base mutation in RNA using T4 RNA ligase-based nick-joining or DNAzyme-based nick-generation" Anal. Biochem., 414, 303-305.

Kim, M. Y.; Kim, Y. S. (co-first author); Kim, J.; Hah, S. S.*; Kim, T. J.; Kim, Y. D.* (Mar 2011). "Quantum dots functionalized to quantify NADPH and their use for NADP+-dependent biocatalyzed transformations" Biotechnol. Lett., 33, 623-628.

Kim, I.-H.; Kim, M. Y.; Cheong, M.; Hah, S. S.* (Feb 2011). "RNA-mediated metal-metal bond formation in the hexagonal Pd nanoparticle synthesis is not influenced by 5’-thiolation of RNA" Bull. Korean Chem. Soc., 32, 722-724.

Shin, S.; Kim, Y. S.; Kang, H.-J.; Hah, S. S.* (Jul 2010). "Quantum dot-based aptasensor for sensitive protein detection" Bull. Korean Chem. Soc., 31, 2091-2093.

Kim, Y. S.; Shin, S. (co-first author); Cheong, M.; Hah, S. S.* (Jul 2010). "Mechanistic insights into in vitro DNA adduction of oxaliplatin" Bull. Korean Chem. Soc., 31, 2043-2046.

Kim, I.-H.; Shin, S. (co-first author); Jeong, Y.-J.; Hah, S. S.* (Jun 2010). "Two-step synthesis of 5’-deoxy-5’-thioguanosine-5’-monophosphorothioate and its incorporation efficiency into 5’-terminus of RNA for preparation of thiol-functionalized RNA" Tet. Lett., 51, 3446-3448.

Shin, S.; Kim, I.-H.; Kang, W.; Yang, J. K.; Hah, S. S.* (Jun 2010). "An alternative to Western blot analysis using RNA aptamer-functionalized quantum dots" Bioorg. Med. Chem. Lett., 20, 3322-3325.

Kim, K.; Kim, T. H.; Choi, J. H.; Lee, J. Y.; Hah, S. S.; Yoo, H.-O.; Hwang, S. S.; Ryu, K. N.; Kim, H. J.; Kim, J.* (May 2010). "Synthesis of a pH-sensitive PEO-based block copolymer and its application for the stabilization of iron oxide nanoparticles" Macromol. Chem. Phys., 211, 1127-1136.

Hah, S. S.*; Henderson, P. T.; Turteltaub, K. W. (Apr 2010). "Towards biomarker-dependent individualized chemotherapy: Exploring cell-specific differences in oxaliplatin-DNA adduct distribution using accelerator mass spectrometry" Bioorg. Med. Chem. Lett., 20, 2448-2451.

Lee, S. Y.; Kim, J.-S.; Hah, S. S.* (Sep 2009). "DNA adduct formation of 17beta-estradiol in MCF-7 human breast cancer cells" Bull. Korean Chem. Soc., 30, 2125-2128.

Hah, S. S.*; Henderson, P. T.; Turteltaub, K. W. (Jun 2009). "Recent advances in biomedical applications of accelerator mass spectrometry" J. Biomed. Sci., 16, 54 & 111 (Review).

     # "Highly accessed" article (#37 out of all the papers published in J. Biomed. Sci., as of Sep 2012).

Hah, S. S.*; Kim, J. (Mar 2009). "Elimination of Delta3→Delta2 isomerization through a modified purification" Bull. Korean Chem. Soc., 30, 735-738.

Chung, S.-W.; Presley, A. D.; Elhadj, S.; Hok, S.; Hah, S. S.; Chernov, A. A.; Francis, M. B.; Eaton, B. E.; Feldheim, D. L.; de Yoreo, J. J.* (Feb 2008). "Scanning probe-based fabrication of 3D nanostructures via affinity templates, functional RNA and meniscus-mediated surface remodeling" Scanning: The Journal of Scanning Microscopies, 30, 159-171.

Mundt, J. M.; Hah, S. S. (co-first author); Sumbad, R. A.; Schramm, V. L.; Henderson, P. T.* (Jan 2008). "Incorporation of extracellular 8-oxodG into DNA and RNA requires purine nucleoside phosphorylase in MCF-7 cells" Nucl. Acids Res., 36, 228-236.

Hah, S. S.*; Sumbad, R. A.; de Vere White, R. W.; Turteltaub, K. W.; Henderson, P. T.* (Dec 2007). "Characterization of oxaliplatin-DNA adduct formation in DNA and differentiation of cancer cell drug sensitivity at microdose concentrations" Chem. Res. Toxicol., 20, 1745-1751.

     # Featured in Lawrence Livermore National Laboratory Newsline, Vol. 33 (41), December 14 (2007).

Hah, S. S.; Mundt, J. M. (co-first author); Kim, H. M.; Sumbad, R. A.; Turteltaub, K. W.; Henderson, P. T.* (Jul 2007). "Measurement of 7,8-dihydro-8-oxo-2’-deoxyguanosine metabolism in MCF-7 cells at low concentrations using accelerator mass spectrometry" Proc. Natl. Acad. Sci. USA, 104, 11203-11208 (highlighted with cover picture).

     # Featured in PNAS Commentary, “8-Oxo-deoxyguanosine: Reduce, reuse, recycle?” Proc. Natl. Acad. Sci. USA., 104, 13535 (2007).
     # Featured on the cover of Lawrence Livermore National Laboratory Newsline, Vol. 32 (20), July 13 (2007).
     # Featured in Lawrence Livermore National Laboratory Science & Technology Review, October (2007).

Hah, S. S.; Mundt, J. M.; Ubick, E. A.; Turteltaub, K. W.; Gregg, J. P.; Henderson, P. T.* (Jun 2007). "A sample preparation protocol for quantitation of radiolabeled nucleoside incorporation into DNA by accelerator mass spectrometry" Nucl. Instr. Methods Phys. Res. B, 259, 763-766.

Hah, S. S.*; Stivers, K. M.; de Vere White, R. W.; Henderson, P. T.* (May 2006). "Kinetics of carboplatin-DNA binding in genomic DNA and blassder cancer cells as determined by accelerator mass spectrometry" Chem. Res. Toxicol., 19, 622-626.

     # Featured on the cover of Lawrence Livermore National Laboratory Science & Technology Review, March (2007).

Hah, S. S.; Kim, H. M.; Sumbad, R. A.; Henderson, P. T.* (Aug 2005). "Hydantoin derivative formation from oxidation of 7,8-dihydro-8-oxo-2’-deoxyguanosine (8-oxodG) and incorporation of 14C-labeled 8-oxodG into the DNA of human breast cancer cells" Bioorg. Med. Chem. Lett., 15, 3627-3631.

Henderson, P. T.; Neeley, W. L.; Delaney, J. C.; Gu, F.; Niles, J. C.; Hah, S. S.; Tannenbaum, S. R.; Essigmann, J. M.* (Jan 2005). "Urea lesion formation in DNA as a consequence of 7,8-dihydro-8-oxoguanine oxidation and hydrolysis provides a potent source of point mutations" Chem. Res. Toxicol., 18, 12-18.

     # The 7th most-cited Chem. Res. Toxicol. Article in 2005.

Song, J. B.; Hah, S. S.; Suh, J.* (Nov 2004). "Cyclen-containing inhibitors of carboxypeptidase A synthesized in search of target-selective artificial proteases" Bull. Korean Chem. Soc., 25, 1703-1706.

Lee, S. H.*; Kim, D.-J.; Chang, C.-C.; Hah, S. S.; Suh, J. (Nov 1998). "An efficient synthesis of ethylenimine dendrimer" Bull. Korean Chem. Soc., 19, 1270-1273.

Suh, J.*; Hah, S. S. (Sep 1998). "Organic artificial proteinase with active site comprising three salicylate residues" J. Am. Chem. Soc., 120, 10088-10093.

Suh, J.*; Lee, S. H.; Kim, S. M.; Hah, S. S. (Aug 1997). "Conformational flexibility of poly(ethylenimine) and its derivatives" Bioorganic Chemistry, 25, 221-231.

Suh, J.*; Hah, S. S.; Lee, S. H. (Feb 1997). "Dendrimer poly(ethylenimine)s linked to beta-cyclodextrin" Bioorganic Chemistry, 25, 63-75.

International Conference Paper(s)

Chung, S.-W.; Presley, A. D.; Elhadj, S.; Hok, S.; Hah, S. S.; Chernov, A. A.; Francis, M. B.; Eaton, B. E.; Feldheim, D. L.; de Yoreo, J. J.* (2008) Scanning probe-based fabrication of 3D nanostructures via affinity templates, functional RNA and meniscus-mediated surface remodeling. The 10th Annual Nanotech Conference 2008, Boston, MA, June 1-5, 2008. NSTI-Nanotech, Nanotechnology 2008, Vol. 1, 501-508 (ISBN: 978-1-4200-8503-7).

Patents

<출원>

하상수, 강성묵. Pincers comprising antibody and aptamer conjugated via a linker which binds to the same target material and use thereof. Filed on Jun. 28, 2016 (US Patent Application Number: 15/108,753).

Turteltaub, K. W.; Henderson, P. T.; Hah, S. S. Real-Time Individualized Therapy Evaluation. Filed on Jun. 21, 2007 (US Patent Application Number: 11/821,174, International PCT Application Number: PCT/US2008/063096).

<등록>

하상수, 조예슬, 이은정. 팔라듐 이온 특이적 DNA 앱타머 및 이의 선별 방법, 대한민국특허, 등록번호: 10-1679140, 등록일: 2016년 11월 17일.

하상수, 이은정. PNA 앱타머를 이용한 표적 분자의 검출방법, 대한민국특허, 등록번호: 10-1535709, 등록일: 2015년 7월 3일.

하상수, 서승관, 송성은, 오흥범, 황상현. 형광공명 에너지 전이 현상을 유발시키는 형광물질이 표지된 앱타머를 포함하는 표적물질 검출 또는 정량분석용 조성물, 대한민국특허, 등록번호: 10-1515723, 등록일: 2015년 4월 21일.

하상수, 박준희, 조예슬, 이은정. 앱타머를 포함하는 ELISA 변형 키트, 대한민국특허, 등록번호: 10-1515306, 등록일: 2015년 4월 20일.

하상수, 신선미, 남혜연, 이은정. 신규한 양자점-앱타머 결합체 및 이의 용도, 대한민국특허, 등록번호: 10-1510513, 등록일: 2015년 4월 2일.

하상수, 이관호. 앱타머 칩을 이용한 표적 단백질의 검출 및 정량 방법, 대한민국특허, 등록번호: 10-1502204, 등록일: 2015년 3월 6일.

하상수, 김지수, 이관호. 앱타머 칩을 이용한 표적 세포의 검출 및 정량 방법, 대한민국특허, 등록번호: 10-1429817, 등록일: 2014년 8월 6일.

하상수, 김일현, 임현경, 신선미, 남혜연. 히스티딘 태그를 가진 단백질의 정제를 위한 고형 지지체 및 이를 이용한 정제 방법, 대한민국특허, 등록번호: 10-1333158, 등록일: 2013년 11월 20일.

하상수, 김지수. 우라닐 이온-특이적 DNA 앱타머, 대한민국특허, 등록번호: 10-1238297, 등록일: 2013년 2월 22일, PCT 출원 2012.02.07.

하상수, 김예슬, 신선미, 김민영, 김지수, 김일현, 정동희. 양자점-앱타머 접합체를 이용한 생분석 방법, 대한민국특허, 등록번호: 10-1090982, 등록일: 2011년 12월 1일.

하상수. 가교결합과 가속 질량 분석법의 조합에 의한 단백질-리간드 상호작용의 확인과 정량화 방법, 대한민국특허, 등록번호: 10-1137502, 등록일: 2012년 4월 10일, PCT 출원 2010.01.11.

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